Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.042 0.113 -9999.0 0.0 -0.353 6.0 6.0 IHH -0.128 0.199 -9999.0 0.0 -0.407 84.0 84.0 SHH Np/Cholesterol/GAS1 -0.093 0.102 -9999.0 0.0 -0.204 113.0 113.0 LRPAP1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.092 0.101 0.203 113.0 -9999.0 0.0 113.0 SMO/beta Arrestin2 -0.084 0.168 -9999.0 0.0 -0.305 82.0 82.0 SMO -0.092 0.176 -9999.0 0.0 -0.324 82.0 82.0 AKT1 -0.035 0.088 -9999.0 0.0 -0.253 8.0 8.0 ARRB2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.084 0.168 -9999.0 0.0 -0.395 57.0 57.0 ADRBK1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.091 0.174 -9999.0 0.0 -0.32 82.0 82.0 STIL -0.039 0.093 -9999.0 0.0 -0.26 8.0 8.0 DHH N/PTCH2 -0.018 0.068 -9999.0 0.0 -0.271 17.0 17.0 DHH N/PTCH1 -0.047 0.109 -9999.0 0.0 -0.2 82.0 82.0 PIK3CA 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.006 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.072 0.161 -9999.0 0.0 -0.509 6.0 6.0 determination of left/right symmetry -0.091 0.174 -9999.0 0.0 -0.32 82.0 82.0 PIK3R1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.072 0.16 -9999.0 0.0 -0.505 6.0 6.0 IHH N/Hhip -0.072 0.126 -9999.0 0.0 -0.245 83.0 83.0 DHH N/Hhip -0.007 0.042 -9999.0 0.0 -0.254 7.0 7.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.091 0.174 -9999.0 0.0 -0.32 82.0 82.0 pancreas development -0.005 0.063 -9999.0 0.0 -0.373 7.0 7.0 HHAT 0.005 0.025 -9999.0 0.0 -0.395 1.0 1.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.172 0.2 -9999.0 0.0 -0.395 112.0 112.0 somite specification -0.091 0.174 -9999.0 0.0 -0.32 82.0 82.0 SHH Np/Cholesterol/PTCH1 -0.041 0.098 -9999.0 0.0 -0.277 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.017 0.054 -9999.0 0.0 -0.201 18.0 18.0 SHH Np/Cholesterol/Megalin -0.006 0.027 -9999.0 0.0 -0.213 2.0 2.0 SHH 0.005 0.032 -9999.0 0.0 -0.169 8.0 8.0 catabolic process -0.058 0.124 -9999.0 0.0 -0.234 82.0 82.0 SMO/Vitamin D3 -0.063 0.132 -9999.0 0.0 -0.241 82.0 82.0 SHH Np/Cholesterol/Hhip -0.009 0.038 -9999.0 0.0 -0.201 7.0 7.0 LRP2 0.002 0.031 -9999.0 0.0 -0.242 4.0 4.0 receptor-mediated endocytosis -0.075 0.107 -9999.0 0.0 -0.322 15.0 15.0 SHH Np/Cholesterol/BOC -0.049 0.087 -9999.0 0.0 -0.206 57.0 57.0 SHH Np/Cholesterol/CDO -0.02 0.058 -9999.0 0.0 -0.2 22.0 22.0 mesenchymal cell differentiation 0.009 0.037 0.2 7.0 -9999.0 0.0 7.0 mol:Vitamin D3 -0.039 0.1 -9999.0 0.0 -0.278 7.0 7.0 IHH N/PTCH2 -0.083 0.136 0.124 4.0 -0.256 91.0 95.0 CDON -0.027 0.111 -9999.0 0.0 -0.395 21.0 21.0 IHH N/PTCH1 -0.056 0.128 -9999.0 0.0 -0.237 82.0 82.0 Megalin/LRPAP1 -0.002 0.019 -9999.0 0.0 -0.154 4.0 4.0 PTCH2 -0.02 0.101 -9999.0 0.0 -0.395 17.0 17.0 SHH Np/Cholesterol -0.004 0.022 -9999.0 0.0 -0.207 1.0 1.0 PTCH1 -0.058 0.125 -9999.0 0.0 -0.235 82.0 82.0 HHIP -0.005 0.063 -9999.0 0.0 -0.373 7.0 7.0