Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 epithelial cell differentiation -0.082 0.032 -9999.0 0.0 -9999.0 0.0 0.0 CYFIP2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.003 0.033 -9999.0 0.0 -0.293 3.0 3.0 EPHA2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.099 0.13 -9999.0 0.0 -0.453 29.0 29.0 CTNND1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.07 0.036 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.078 0.048 -9999.0 0.0 -0.238 10.0 10.0 EGF -0.014 0.089 -9999.0 0.0 -0.395 13.0 13.0 NCKAP1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.054 0.029 -9999.0 0.0 -9999.0 0.0 0.0 cortical microtubule organization -0.082 0.032 -9999.0 0.0 -9999.0 0.0 0.0 GO:0000145 -0.067 0.034 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.082 0.032 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.052 0.02 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.057 0.033 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.209 0.084 -9999.0 0.0 -0.242 219.0 219.0 EGFR/EGFR/EGF/EGF -0.079 0.048 -9999.0 0.0 -0.248 13.0 13.0 RhoA/GDP -0.074 0.029 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.059 0.033 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.005 0.025 -9999.0 0.0 -0.395 1.0 1.0 GIT1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.005 0.025 -9999.0 0.0 -0.395 1.0 1.0 IGF1 -0.117 0.186 -9999.0 0.0 -0.395 78.0 78.0 DIAPH1 0.009 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway 0.082 0.032 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.053 0.02 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.06 0.033 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.064 0.035 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.068 0.026 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.057 0.022 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.079 0.049 -9999.0 0.0 -0.242 10.0 10.0 HGF/MET -0.093 0.069 -9999.0 0.0 -0.258 33.0 33.0 HGF -0.05 0.14 -9999.0 0.0 -0.391 36.0 36.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 actin cable formation -0.021 0.026 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.156 0.049 -9999.0 0.0 -0.18 197.0 197.0 KIFC3 -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 NCK1/GIT1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.082 0.032 -9999.0 0.0 -9999.0 0.0 0.0 EXOC4 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.045 0.017 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.097 0.037 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer/IGF1 -0.124 0.091 -9999.0 0.0 -0.262 70.0 70.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.007 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PLEKHA7 -0.071 0.036 -9999.0 0.0 -9999.0 0.0 0.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.048 0.032 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0 regulation of cell-cell adhesion -0.059 0.033 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.02 0.015 -9999.0 0.0 -9999.0 0.0 0.0