E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.08 0.107 0.285 4.0 -0.275 6.0 10.0 KLHL20 0.04 0.053 0.161 8.0 -9999.0 0.0 8.0 CYFIP2 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.064 0.082 0.239 19.0 -9999.0 0.0 19.0 ENAH 0.08 0.12 0.29 9.0 -0.279 9.0 18.0 AP1M1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.02 0.001 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.02 0.038 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.006 0.017 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.157 0.09 0.213 173.0 -9999.0 0.0 173.0 RAPGEF1 0.064 0.113 0.265 18.0 -0.259 10.0 28.0 CTNND1 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.096 0.125 0.264 1.0 -0.283 10.0 11.0 CRK 0.068 0.113 0.279 14.0 -0.271 10.0 24.0 E-cadherin/gamma catenin/alpha catenin 0.171 0.078 0.211 192.0 -9999.0 0.0 192.0 alphaE/beta7 Integrin 0.027 0.009 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.122 0.143 0.295 64.0 -0.281 7.0 71.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.0 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.016 -9999.0 0.0 -0.154 1.0 1.0 PI3K 0.003 0.024 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.189 0.072 0.22 205.0 -9999.0 0.0 205.0 TIAM1 0.018 0.02 -9999.0 0.0 -0.285 1.0 1.0 E-cadherin(dimer)/Ca2+ 0.151 0.081 0.199 178.0 -9999.0 0.0 178.0 AKT1 0.007 0.027 0.099 13.0 -9999.0 0.0 13.0 PIK3R1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.26 0.1 0.301 208.0 -9999.0 0.0 208.0 RhoA/GDP 0.07 0.074 0.239 19.0 -9999.0 0.0 19.0 actin cytoskeleton organization 0.034 0.044 0.135 14.0 -9999.0 0.0 14.0 CDC42/GDP 0.064 0.083 0.239 19.0 -9999.0 0.0 19.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.077 0.037 0.141 2.0 -9999.0 0.0 2.0 ITGB7 0.02 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.162 0.087 0.213 178.0 -9999.0 0.0 178.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.141 0.076 0.186 179.0 -9999.0 0.0 179.0 mol:GDP 0.06 0.086 0.248 19.0 -9999.0 0.0 19.0 CDC42/GTP/IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.071 0.082 0.243 18.0 -9999.0 0.0 18.0 RAC1/GTP/IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.028 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.029 0.037 0.177 5.0 -9999.0 0.0 5.0 NME1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.074 0.116 0.276 2.0 -0.28 10.0 12.0 regulation of cell-cell adhesion 0.013 0.03 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.013 0.023 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.04 0.057 0.193 15.0 -9999.0 0.0 15.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.159 0.086 0.211 174.0 -9999.0 0.0 174.0 CCND1 0.032 0.037 0.163 4.0 -9999.0 0.0 4.0 VAV2 0.093 0.119 0.352 2.0 -9999.0 0.0 2.0 RAP1/GDP 0.055 0.068 0.225 17.0 -9999.0 0.0 17.0 adherens junction assembly 0.074 0.114 0.274 2.0 -0.273 10.0 12.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.142 0.083 0.195 166.0 -9999.0 0.0 166.0 E-cadherin/beta catenin 0.107 0.05 0.134 179.0 -9999.0 0.0 179.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.082 0.124 0.292 13.0 -0.28 10.0 23.0 PIK3CA 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.009 0.032 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin 0.16 0.086 0.211 179.0 -9999.0 0.0 179.0 ITGAE 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.094 0.127 -9999.0 0.0 -0.288 10.0 10.0