Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.009 0.063 0.202 18.0 -0.217 1.0 19.0 KIRREL 0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.009 0.063 0.217 1.0 -0.202 18.0 19.0 PLCG1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.027 0.056 0.206 1.0 -0.159 16.0 17.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.007 0.05 -9999.0 0.0 -0.191 15.0 15.0 FYN -0.001 0.086 0.209 27.0 -0.155 14.0 41.0 mol:Ca2+ 0.027 0.052 -9999.0 0.0 -0.159 15.0 15.0 mol:DAG 0.028 0.053 -9999.0 0.0 -0.159 15.0 15.0 NPHS2 -0.016 0.019 -9999.0 0.0 -9999.0 0.0 0.0 mol:IP3 0.028 0.053 -9999.0 0.0 -0.159 15.0 15.0 regulation of endocytosis 0.016 0.052 0.186 1.0 -0.146 16.0 17.0 Nephrin/NEPH1/podocin/Cholesterol 0.019 0.051 0.192 1.0 -0.147 18.0 19.0 establishment of cell polarity 0.009 0.063 0.217 1.0 -0.202 18.0 19.0 Nephrin/NEPH1/podocin/NCK1-2 0.027 0.056 -9999.0 0.0 -0.151 14.0 14.0 Nephrin/NEPH1/beta Arrestin2 0.018 0.054 0.193 1.0 -0.15 15.0 16.0 NPHS1 0.004 0.042 0.289 3.0 -9999.0 0.0 3.0 Nephrin/NEPH1/podocin 0.015 0.053 0.193 1.0 -0.139 23.0 24.0 TJP1 0.02 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.015 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.028 0.053 -9999.0 0.0 -0.16 15.0 15.0 CD2AP 0.019 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/GRB2 0.027 0.056 0.206 1.0 -0.16 16.0 17.0 GRB2 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.007 0.076 0.21 20.0 -0.145 13.0 33.0 cytoskeleton organization -0.017 0.057 0.183 7.0 -0.194 14.0 21.0 Nephrin/NEPH1 0.01 0.044 0.178 1.0 -0.133 18.0 19.0 Nephrin/NEPH1/ZO-1 0.019 0.056 0.203 1.0 -0.162 18.0 19.0