Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.046 0.082 -9999.0 0.0 -0.369 3.0 3.0 IHH 0.017 0.043 0.306 4.0 -0.137 3.0 7.0 SHH Np/Cholesterol/GAS1 -0.07 0.072 0.152 3.0 -0.153 97.0 100.0 LRPAP1 0.018 0.006 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.07 0.071 0.152 97.0 -0.151 3.0 100.0 SMO/beta Arrestin2 -0.093 0.164 -9999.0 0.0 -0.331 61.0 61.0 SMO -0.093 0.158 -9999.0 0.0 -0.338 55.0 55.0 AKT1 -0.043 0.114 -9999.0 0.0 -0.487 9.0 9.0 ARRB2 0.019 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.043 0.12 -9999.0 0.0 -0.285 48.0 48.0 ADRBK1 0.02 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.095 0.158 -9999.0 0.0 -0.336 57.0 57.0 STIL -0.042 0.082 0.177 7.0 -0.248 4.0 11.0 DHH N/PTCH2 0.014 0.057 -9999.0 0.0 -0.2 16.0 16.0 DHH N/PTCH1 -0.037 0.093 -9999.0 0.0 -0.186 62.0 62.0 PIK3CA 0.013 0.01 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.017 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH -0.071 0.133 -9999.0 0.0 -0.531 3.0 3.0 determination of left/right symmetry -0.095 0.158 -9999.0 0.0 -0.336 57.0 57.0 PIK3R1 0.019 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.071 0.132 -9999.0 0.0 -0.526 3.0 3.0 IHH N/Hhip -0.029 0.103 0.201 5.0 -0.191 64.0 69.0 DHH N/Hhip 0.024 0.035 0.217 1.0 -0.2 5.0 6.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.095 0.158 -9999.0 0.0 -0.336 57.0 57.0 pancreas development 0.005 0.049 0.301 1.0 -0.285 5.0 6.0 HHAT 0.018 0.02 -9999.0 0.0 -0.285 1.0 1.0 PI3K 0.018 0.015 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.111 0.151 -9999.0 0.0 -0.285 104.0 104.0 somite specification -0.095 0.158 -9999.0 0.0 -0.336 57.0 57.0 SHH Np/Cholesterol/PTCH1 -0.047 0.075 0.211 3.0 -0.254 4.0 7.0 SHH Np/Cholesterol/PTCH2 -0.024 0.043 0.129 6.0 -0.153 17.0 23.0 SHH Np/Cholesterol/Megalin -0.011 0.042 0.168 10.0 -0.154 1.0 11.0 SHH -0.012 0.041 0.197 7.0 -0.201 1.0 8.0 catabolic process -0.051 0.097 -9999.0 0.0 -0.206 62.0 62.0 SMO/Vitamin D3 -0.067 0.113 0.342 1.0 -0.25 53.0 54.0 SHH Np/Cholesterol/Hhip -0.016 0.036 0.137 7.0 -0.154 6.0 13.0 LRP2 0.018 0.039 0.301 4.0 -9999.0 0.0 4.0 receptor-mediated endocytosis -0.067 0.107 0.292 1.0 -0.302 14.0 15.0 SHH Np/Cholesterol/BOC -0.038 0.061 0.134 5.0 -0.154 45.0 50.0 SHH Np/Cholesterol/CDO -0.019 0.041 0.129 6.0 -0.152 13.0 19.0 mesenchymal cell differentiation 0.016 0.035 0.153 6.0 -0.136 7.0 13.0 mol:Vitamin D3 -0.039 0.082 0.194 8.0 -0.255 4.0 12.0 IHH N/PTCH2 -0.039 0.11 0.195 4.0 -0.198 73.0 77.0 CDON 0.0 0.068 -9999.0 0.0 -0.285 13.0 13.0 IHH N/PTCH1 -0.038 0.103 -9999.0 0.0 -0.208 62.0 62.0 Megalin/LRPAP1 0.029 0.026 0.22 4.0 -9999.0 0.0 4.0 PTCH2 -0.002 0.078 -9999.0 0.0 -0.285 17.0 17.0 SHH Np/Cholesterol -0.01 0.015 -9999.0 0.0 -0.148 1.0 1.0 PTCH1 -0.051 0.097 -9999.0 0.0 -0.207 62.0 62.0 HHIP 0.005 0.049 0.301 1.0 -0.285 5.0 6.0