Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.152 0.217 0.494 2.0 -0.565 1.0 3.0 IHH 0.007 0.295 -9999.0 0.0 -0.957 3.0 3.0 SHH Np/Cholesterol/GAS1 0.019 0.013 -9999.0 0.0 -9999.0 0.0 0.0 LRPAP1 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.018 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SMO/beta Arrestin2 0.084 0.203 -9999.0 0.0 -0.591 1.0 1.0 SMO 0.069 0.212 -9999.0 0.0 -0.621 1.0 1.0 AKT1 0.055 0.115 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.024 0.006 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.069 0.209 -9999.0 0.0 -0.61 1.0 1.0 STIL 0.08 0.159 -9999.0 0.0 -0.49 1.0 1.0 DHH N/PTCH2 0.033 0.012 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.071 0.18 -9999.0 0.0 -0.52 2.0 2.0 PIK3CA 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.023 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.17 0.233 -9999.0 0.0 -0.636 1.0 1.0 determination of left/right symmetry 0.069 0.209 -9999.0 0.0 -0.61 1.0 1.0 PIK3R1 0.025 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.17 0.232 -9999.0 0.0 -0.63 1.0 1.0 IHH N/Hhip -0.279 0.454 -9999.0 0.0 -0.836 14.0 14.0 DHH N/Hhip -0.24 0.386 -9999.0 0.0 -0.786 12.0 12.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.069 0.209 -9999.0 0.0 -0.61 1.0 1.0 pancreas development -0.311 0.472 -9999.0 0.0 -0.978 12.0 12.0 HHAT 0.019 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.023 0.007 -9999.0 0.0 -9999.0 0.0 0.0 somite specification 0.069 0.209 -9999.0 0.0 -0.61 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.045 0.146 -9999.0 0.0 -0.514 1.0 1.0 SHH Np/Cholesterol/PTCH2 0.021 0.012 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/Megalin -0.091 0.243 -9999.0 0.0 -0.577 7.0 7.0 SHH 0.012 0.007 -9999.0 0.0 -9999.0 0.0 0.0 catabolic process 0.083 0.203 -9999.0 0.0 -0.53 3.0 3.0 SMO/Vitamin D3 0.101 0.201 0.45 2.0 -0.557 1.0 3.0 SHH Np/Cholesterol/Hhip -0.183 0.294 -9999.0 0.0 -0.594 12.0 12.0 LRP2 -0.166 0.401 -9999.0 0.0 -0.98 7.0 7.0 receptor-mediated endocytosis 0.01 0.263 -9999.0 0.0 -0.726 2.0 2.0 SHH Np/Cholesterol/BOC 0.019 0.013 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol/CDO 0.02 0.013 -9999.0 0.0 -9999.0 0.0 0.0 mesenchymal cell differentiation 0.182 0.292 0.589 12.0 -9999.0 0.0 12.0 mol:Vitamin D3 0.117 0.186 0.46 2.0 -0.522 1.0 3.0 IHH N/PTCH2 0.011 0.205 -9999.0 0.0 -0.659 3.0 3.0 CDON 0.024 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.116 0.217 -9999.0 0.0 -0.538 3.0 3.0 Megalin/LRPAP1 -0.121 0.327 -9999.0 0.0 -0.784 7.0 7.0 PTCH2 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol 0.013 0.007 -9999.0 0.0 -9999.0 0.0 0.0 PTCH1 0.083 0.204 -9999.0 0.0 -0.532 3.0 3.0 HHIP -0.312 0.473 -9999.0 0.0 -0.98 12.0 12.0