Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	107 (69%)	47	0.13362	1	0.0064999	1	0.02563	1	0.16099	1	0.21792	1	0.4935	1	0.01167	1	1	1	0.86741	1
TP53	73 (47%)	81	0.0050899	1	0.00337	0.728	9.9999e-06	0.0023	0.19808	1	0.73682	1	0.088649	1	0.00116	0.255	0.62055	1	0.49402	1
KRAS	59 (38%)	95	0.03368	1	0.0074999	1	0.7176	1	0.71918	1	0.99238	1	0.13415	1	0.72205	1	0.63137	1	0.52367	1
NRAS	15 (10%)	139	0.076819	1	0.091879	1	0.86555	1	0.46808	1	0.95419	1	0.63909	1	0.73245	1	1	1	1	1
SMAD4	18 (12%)	136	0.30297	1	0.22801	1	0.0079999	1	0.85387	1	0.57203	1	0.46825	1	0.51479	1	1	1	0.86359	1
FBXW7	29 (19%)	125	0.2255	1	0.056019	1	0.00194	0.423	0.00349	0.75	0.19184	1	0.85146	1	0.00442	0.937	1	1	0.17909	1
SMAD2	10 (6%)	144	0.099149	1	0.1084	1	0.050209	1	1	1	0.94053	1	0.66802	1	0.80636	1	1	1	1	1
BRAF	20 (13%)	134	9.9999e-06	0.0023	9.9999e-06	0.0023	8.9999e-05	0.0202	0.72087	1	0.52321	1	0.00055999	0.124	9.9999e-06	0.0023	0.46154	1	0.03812	1
FAM123B	19 (12%)	135	0.20681	1	0.18246	1	0.0094599	1	0.28659	1	0.18704	1	0.20872	1	0.35065	1	0.42457	1	0.41641	1
MGC42105	10 (6%)	144	0.00393	0.841	0.14055	1	0.22423	1	0.4132	1	0.17354	1	0.14446	1	0.19333	1	1	1	0.59342	1
ACVR1B	13 (8%)	141	0.36633	1	0.15703	1	0.0061399	1	0.70236	1	0.43575	1	0.04683	1	0.10098	1	1	1	0.37164	1
DNMT1	12 (8%)	142	0.02945	1	0.0081599	1	0.073759	1	0.050889	1	0.34678	1	0.32742	1	0.01102	1	1	1	0.0046	0.971
PCBP1	4 (3%)	150	0.3299	1	0.43211	1	0.64083	1	NA	NA	NA	NA	1	1	0.6378	1	1	1	0.60414	1
CDC27	10 (6%)	144	0.00215	0.467	0.073409	1	0.00436	0.929	1	1	0.95436	1	0.82105	1	0.01956	1	0.18612	1	0.01503	1
PIK3CA	26 (17%)	128	0.32937	1	0.57991	1	0.0088099	1	0.11672	1	0.85453	1	0.31576	1	0.55907	1	0.51361	1	0.23068	1
BCOR	6 (4%)	148	0.03391	1	0.054819	1	0.02116	1	0.19936	1	0.60421	1	1	1	0.12009	1	1	1	0.094579	1
ZHX2	8 (5%)	146	0.21747	1	0.2261	1	0.2473	1	0.2327	1	0.57874	1	0.78194	1	0.084569	1	1	1	0.19371	1
KLHL5	5 (3%)	149	0.37407	1	0.29929	1	0.35657	1	0.22042	1	0.87644	1	1	1	1	1	1	1	0.1611	1
CASP8	10 (6%)	144	0.00046	0.103	4e-05	0.009	0.00070999	0.157	0.01544	1	0.14684	1	0.54456	1	9.9999e-06	0.0023	1	1	0.077139	1
PCDHGB1	7 (5%)	147	0.10825	1	0.26804	1	0.11247	1	0.43235	1	1	1	0.53106	1	0.51841	1	1	1	0.19541	1
UBXN11	3 (2%)	151	NA	NA	NA	NA	0.3512	1	NA	NA	NA	NA	0.2332	1	0.057059	1	1	1	0.60404	1
MIER3	10 (6%)	144	0.00136	0.298	0.0051599	1	0.00462	0.971	0.7707	1	0.7841	1	0.81887	1	0.01188	1	1	1	0.17702	1
TBC1D10C	3 (2%)	151	0.23836	1	0.12938	1	1	1	NA	NA	NA	NA	0.23135	1	0.24215	1	1	1	0.60401	1
TCF7L2	11 (7%)	143	0.21988	1	1	1	0.90747	1	0.95033	1	0.85996	1	0.66361	1	1	1	1	1	0.31808	1
PCDHGA9	5 (3%)	149	0.37269	1	0.41725	1	0.54273	1	0.64907	1	0.38488	1	0.39403	1	0.25738	1	1	1	1	1
PCDHGA7	5 (3%)	149	0.7027	1	0.84813	1	0.54407	1	NA	NA	NA	NA	0.39174	1	0.66807	1	1	1	0.35994	1
KLK2	3 (2%)	151	0.419	1	0.131	1	1	1	NA	NA	NA	NA	1	1	0.24113	1	1	1	NA	NA