rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(121), AXIN1(1), BTRC(2), CREBBP(21), CSNK1A1(2), CSNK1D(3), CSNK2A1(4), CTBP1(1), CTNNB1(8), GSK3B(7), HDAC1(2), MAP3K7(2), NLK(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(2), WNT1(1) 6339468 181 120 145 22 26 21 2 24 74 34 2.88e-07 <1.00e-15 <1.11e-13 2 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 ADAM17(6), APC(121), AXIN1(1), BTRC(2), CTNNB1(8), DLL1(1), GSK3B(7), PSEN1(3), WNT1(1) 4597626 150 112 114 13 16 13 1 16 70 34 3.03e-09 <1.00e-15 <1.11e-13 3 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(121), ASAH1(3), CASP3(1), CERK(1), CREB1(1), CREB3(2), CREB5(2), DAG1(4), EPHB2(7), GNAQ(3), ITPKB(4), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3) 6337879 172 112 134 22 19 19 4 25 71 34 1.10e-06 <1.00e-15 <1.11e-13 4 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(27), ATR(13), CDC25C(3), CHEK1(1), CHEK2(1), TP53(76) 3665686 121 94 95 3 38 20 2 24 36 1 5.43e-09 <1.00e-15 <1.11e-13 5 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(121), CDH1(4), CREBBP(21), EP300(13), MAP2K1(3), MAP3K7(2), MAPK3(2), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7) 5814805 185 118 148 21 29 26 4 18 74 34 1.28e-07 1.22e-15 1.11e-13 6 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(4), DNAJC3(1), EIF2S2(1), MAP3K14(2), NFKB1(3), RELA(2), TP53(76) 2157493 89 78 63 6 36 13 0 12 28 0 1.77e-05 1.22e-15 1.11e-13 7 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(1), SP1(2), SP3(2), TP53(76), WT1(4) 1573762 87 81 61 4 34 14 1 12 26 0 2.81e-08 1.33e-15 1.11e-13 8 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(27), BRCA1(5), CDKN1A(1), CHEK1(1), CHEK2(1), MAPK8(2), MDM2(4), MRE11A(3), NFKB1(3), RAD50(5), RBBP8(2), RELA(2), TP53(76) 6728302 136 96 110 9 41 29 2 26 37 1 2.68e-08 1.44e-15 1.11e-13 9 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(121), AXIN1(1), CREBBP(21), CTNNB1(8), EP300(13), GSK3B(7), HDAC1(2), LDB1(3), LEF1(4), PITX2(2), TRRAP(17), WNT1(1) 7283209 200 122 163 25 38 31 2 19 76 34 1.57e-08 2.66e-15 1.82e-13 10 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 CDK2(2), CDK4(2), CDKN1A(1), CDKN1B(1), CDKN2A(1), CFL1(1), E2F2(1), MDM2(4), NXT1(1), TP53(76) 1731869 90 79 64 5 30 15 0 18 27 0 4.99e-07 3.22e-15 1.98e-13 11 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(21), PAX3(5), PML(3), RB1(4), SIRT1(4), SP100(4), TNFRSF1A(1), TP53(76) 4234058 118 93 91 19 41 23 3 19 31 1 0.000430 3.77e-15 2.05e-13 12 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 19 ABCB1(6), AKT1(2), ATM(27), BAX(1), CDKN1A(1), CPB2(1), CSNK1A1(2), CSNK1D(3), FHL2(1), HIF1A(1), IGFBP3(2), MAPK8(2), MDM2(4), NFKBIB(1), NQO1(1), TP53(76) 4649148 131 98 105 6 36 28 1 31 34 1 5.41e-10 4.11e-15 2.05e-13 13 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(27), CDC25A(2), CDC25B(5), CDC25C(3), CDK2(2), CDK4(2), CHEK1(1), MYT1(8), RB1(4), TP53(76), WEE1(3) 4017687 133 101 107 7 39 25 0 32 35 2 3.42e-08 4.33e-15 2.05e-13 14 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 24 ABL1(4), ATM(27), ATR(13), CCNA1(4), CCNE1(3), CDC25A(2), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), GSK3B(7), HDAC1(2), RB1(4), SKP2(1), TFDP1(4), TGFB1(1), TGFB2(5), TP53(76) 6746504 161 104 135 13 52 28 2 36 41 2 8.51e-09 4.77e-15 2.10e-13 15 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(1), MDM2(4), PIK3CA(33), PIK3R1(5), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), RB1(4), TP53(76) 4347679 144 102 103 8 40 45 1 27 30 1 1.53e-11 5.66e-15 2.20e-13 16 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 APAF1(7), ATM(27), BAX(1), BCL2(1), CCNE1(3), CDK2(2), CDK4(2), CDKN1A(1), MDM2(4), PCNA(2), RB1(4), TIMP3(2), TP53(76) 4142972 132 99 106 8 39 23 0 34 34 2 3.40e-08 5.88e-15 2.20e-13 17 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(121), AXIN1(1), CD14(1), CTNNB1(8), GJA1(3), GNAI1(3), GSK3B(7), IRAK1(1), LBP(1), LEF1(4), LY96(2), MYD88(1), NFKB1(3), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), RELA(2), TIRAP(1), TLR4(7), TOLLIP(1), WNT1(1) 6578147 210 123 159 24 32 36 4 29 75 34 6.74e-09 6.44e-15 2.20e-13 18 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 18 DNAJA3(3), IFNG(1), IFNGR1(2), IFNGR2(1), IKBKB(2), JAK2(6), LIN7A(2), NFKB1(3), RB1(4), RELA(2), TNFRSF1A(1), TP53(76), USH1C(5), WT1(4) 4213191 112 87 86 14 40 15 3 22 30 2 0.000109 6.44e-15 2.20e-13 19 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), APAF1(7), ATM(27), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), CASP3(1), CASP6(1), CASP7(1), CASP9(2), PRKCA(2), PTK2(5), STAT1(6), TLN1(5), TP53(76) 6179123 140 102 114 16 46 24 2 31 36 1 1.32e-05 9.33e-15 3.02e-13 20 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(5), ANKRD6(5), APC(121), AXIN1(1), AXIN2(7), CER1(3), CSNK1A1(2), CTNNB1(8), DACT1(5), DKK1(3), DKK2(5), DKK3(2), DKK4(4), FSTL1(5), GSK3A(2), GSK3B(7), LRP1(14), MVP(4), NKD1(3), NKD2(1), PIN1(1), PSEN1(3), PTPRA(2), SENP2(2), SFRP1(2), WIF1(2) 8805492 221 126 184 33 52 22 4 32 77 34 1.00e-06 4.33e-13 1.33e-11 21 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 ACVR1(3), APC(121), AXIN1(1), BMP10(2), BMP4(1), BMP5(4), BMP7(5), BMPR1A(4), BMPR2(6), CHRD(5), CTNNB1(8), GATA4(1), GSK3B(7), MAP3K7(2), MEF2C(7), MYL2(1), NKX2-5(1), NPPA(1), RFC1(10), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TGFBR3(5), WNT1(1) 7954144 215 125 178 31 37 23 2 36 83 34 3.55e-06 4.66e-13 1.37e-11 22 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), BCL2(1), EGFR(10), IGF1R(7), POLR2A(6), PPP2CA(1), PRKCA(2), RB1(4), TEP1(7), TERT(2), TNKS(4), TP53(76), XRCC5(4) 6350983 126 95 100 16 52 18 1 25 29 1 7.13e-06 6.59e-13 1.85e-11 23 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(27), ATR(13), BRCA1(5), BRCA2(11), CHEK1(1), CHEK2(1), FANCA(5), FANCC(3), FANCD2(7), FANCF(1), FANCG(2), HUS1(1), MRE11A(3), RAD1(1), RAD17(2), RAD50(5), TP53(76), TREX1(2) 9948932 166 99 140 14 53 27 5 36 44 1 1.20e-07 3.09e-11 8.27e-10 24 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(27), ATR(13), BRCA1(5), CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(3), CDKN1A(1), CHEK1(1), CHEK2(1), EP300(13), MDM2(4), MYT1(8), PRKDC(13), RPS6KA1(1), TP53(76), WEE1(3), YWHAQ(1) 9166403 179 104 153 21 54 41 3 39 41 1 8.80e-07 2.57e-10 6.59e-09 25 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(3), CDK2(2), CUL1(7), FBXW7(33), RB1(4), TFDP1(4) 1953649 53 36 41 5 21 3 1 17 10 1 0.00100 3.30e-06 8.13e-05 26 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 APAF1(7), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(2), BIRC3(2), CASP2(4), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), FASLG(1), GZMB(1), MAP2K4(9), MAP3K1(6), MAP3K14(2), MAPK10(4), MDM2(4), NFKB1(3), PARP1(4), RELA(2), RIPK1(2), TNFRSF1A(1), TNFSF10(1), TP53(76), TRADD(1), TRAF1(1), TRAF2(1) 8238872 155 99 127 26 54 33 4 30 34 0 4.60e-05 3.68e-06 8.71e-05 27 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(121), AR(4), ASAH1(3), BRAF(21), CCL13(1), CCL15(1), DAG1(4), EGFR(10), GNA11(1), GNA15(3), GNAI1(3), GNAQ(3), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), MAPK10(4), MAPK14(3), PHKA2(5), PIK3CA(33), PIK3CD(2), PIK3R1(5), PITX2(2), PTX3(2), RAF1(4), SRC(3) 11524950 291 131 221 54 59 42 8 74 74 34 9.25e-06 0.000291 0.00665 28 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 13 AKT1(2), CAT(2), GH1(1), GHR(6), IGF1(2), IGF1R(7), PIK3CA(33), PIK3R1(5), SHC1(3), SOD2(4) 2897767 65 43 49 8 18 23 2 17 5 0 0.000606 0.000467 0.0103 29 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3D(1), CD3G(2), CTLA4(1), GRB2(2), HLA-DRA(4), HLA-DRB1(1), ICOS(1), IL2(3), ITK(8), LCK(2), PIK3CA(33), PIK3R1(5), PTPN11(2) 2795313 66 43 50 8 12 28 3 16 5 2 0.00110 0.000665 0.0141 30 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), BAD(1), GRB2(2), IGF1R(7), IRS1(5), MAP2K1(3), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3R1(5), RAF1(4), SHC1(3), SOS1(5) 4144677 74 49 57 9 18 27 5 18 6 0 0.000275 0.000765 0.0157 31 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(121), AXIN1(1), CCND2(1), CCND3(1), CTNNB1(8), DVL2(8), DVL3(2), FBXW2(2), FZD10(4), FZD2(2), FZD3(10), FZD6(3), FZD7(3), FZD8(1), GSK3B(7), LDLR(4), MAPK10(4), MAPK9(3), PAFAH1B1(3), PLAU(2), PPP2R5C(2), PPP2R5E(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PRKD1(10), RHOA(4), SFRP4(3), TCF7(3), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2) 12949820 263 129 225 48 68 34 3 45 79 34 3.97e-07 0.00140 0.0279 32 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), GRB2(2), KLK2(3), NTRK1(6), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), SHC1(3), SOS1(5) 3438791 65 47 47 9 10 25 4 20 6 0 0.00365 0.00407 0.0784 33 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), BAD(1), BCL2L1(1), CASP9(2), CHUK(4), MAP2K1(3), MAPK3(2), NFKB1(3), PIK3CA(33), PIK3R1(5), RAF1(4), RALBP1(4), RALGDS(1), RELA(2), RHOA(4) 4249309 71 46 55 9 22 27 4 11 7 0 0.000278 0.00935 0.175 34 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 CSNK2A1(4), GRB2(2), KLK2(3), MAP2K1(3), MAPK3(2), MAPK8(2), NGFR(2), PIK3CA(33), PIK3R1(5), PLCG1(4), RAF1(4), SHC1(3), SOS1(5) 4201682 72 45 53 8 15 28 5 19 5 0 0.000160 0.0114 0.207 35 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA5(8), GABRA6(4), GPX1(1), PRKCE(4) 1638863 35 25 34 4 12 7 0 12 4 0 0.00625 0.0129 0.227 36 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(3), HLA-DRA(4), HLA-DRB1(1), IL3(3) 658061 11 11 10 2 5 1 0 3 0 2 0.396 0.0148 0.251 37 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(1), CASP3(1), CASP8(11), CFL1(1), CFLAR(2), PDE6D(1) 860111 17 16 16 2 3 3 1 6 4 0 0.142 0.0151 0.251 38 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(3), ALDH1A2(6), BCMO1(4), RDH5(1) 869168 14 12 14 1 6 2 1 4 1 0 0.0547 0.0418 0.678 39 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), BAD(1), CASP9(2), CHUK(4), GH1(1), GHR(6), NFKB1(3), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), RELA(2) 3141022 61 41 46 9 14 24 2 16 5 0 0.00555 0.0481 0.760 40 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCNE1(3), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(2), NFKB1(3), PAK1(4), PIK3CA(33), PIK3R1(5), RAF1(4), RB1(4), RELA(2), TFDP1(4) 4524478 75 42 59 9 16 29 3 20 6 1 0.000250 0.0565 0.870 41 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(5), CDKN1A(1), GRB2(2), MAP2K1(3), NGFR(2), NTRK1(6), PIK3CA(33), PIK3CD(2), SHC1(3), SOS1(5) 3566341 64 44 48 11 14 24 6 16 4 0 0.00626 0.0721 1.000 42 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(33), PIK3R1(5), PLCB1(8), PLCG1(4), PRKCA(2), VAV1(11) 2853900 65 44 50 10 18 23 3 16 5 0 0.00540 0.0794 1.000 43 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(27), CDC25A(2), CDC25B(5), CDC25C(3), CHEK1(1), MYT1(8), WEE1(3) 3124431 49 31 49 4 10 12 0 17 9 1 0.00355 0.0803 1.000 44 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(3), ALDOA(1), ALDOB(5), ALDOC(1), TPI1(1) 843025 11 11 11 1 2 0 0 9 0 0 0.255 0.0823 1.000 45 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 ADRB1(2), AKT1(2), APC(121), ASAH1(3), CAV3(2), DAG1(4), DLG4(2), EPHB2(7), GNAI1(3), GNAQ(3), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), PITX2(2), PTX3(2), RHO(2), RYR1(19) 9812610 221 123 184 49 55 22 5 33 72 34 0.000730 0.0931 1.000 46 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(3), HLA-A(1), ITGB1(6), KLRC3(2), KLRC4(1), KLRD1(1), MAP2K1(3), MAPK3(2), PAK1(4), PIK3CA(33), PIK3R1(5), PTK2B(1), PTPN6(4), VAV1(11) 4066582 77 47 62 12 20 26 4 18 9 0 0.00156 0.187 1.000 47 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 64 APAF1(7), ATM(27), ATR(13), BAI1(2), BAX(1), BID(1), CASP3(1), CASP8(11), CASP9(2), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNG1(2), CDK2(2), CDK4(2), CDK6(1), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), IGF1(2), IGFBP3(2), MDM2(4), MDM4(2), PPM1D(4), PTEN(6), RCHY1(2), RFWD2(4), RPRM(1), RRM2(2), SERPINE1(1), SESN1(2), SESN2(3), SESN3(5), SIAH1(1), STEAP3(1), THBS1(8), TNFRSF10B(2), TP53(76), TSC2(1), ZMAT3(3) 14472686 222 113 194 31 63 47 5 56 49 2 3.75e-07 0.235 1.000 48 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(4), CYP2C9(4) 457981 8 8 8 2 2 1 0 4 1 0 0.708 0.240 1.000 49 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(2), KERA(5), LUM(5) 802145 15 13 15 3 4 6 0 3 2 0 0.245 0.286 1.000 50 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(2), B3GNT1(2), FUT1(1), FUT2(1), FUT9(4), GCNT2(9), ST8SIA1(3) 1344754 22 15 22 4 6 6 1 6 3 0 0.0846 0.306 1.000 51 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(2) 165887 2 2 2 0 1 0 0 0 1 0 0.594 0.308 1.000 52 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 63 ATM(27), CCNA1(4), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDC25A(2), CDK2(2), CDK4(2), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CREB3(2), CREB3L1(3), CREB3L3(1), CREB3L4(1), E2F2(1), E2F3(1), E2F4(1), E2F5(2), GBA2(5), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), MNAT1(1), MYT1(8), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(2), POLE(17), RB1(4), RBL1(3), RPA1(2), RPA2(1), TFDP1(4), TFDP2(1), TNXB(14), TP53(76), WEE1(3) 16465094 233 113 206 31 70 49 1 64 47 2 3.25e-08 0.317 1.000 53 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 CSNK2A1(4), GRB2(2), IGF1(2), IGF1R(7), IRS1(5), MAP2K1(3), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3) 5427148 87 50 70 11 20 32 4 24 7 0 0.000115 0.322 1.000 54 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(3), TPI1(1) 350147 4 4 4 0 0 0 0 4 0 0 0.452 0.323 1.000 55 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), GSK3B(7), IGF1(2), IGF1R(7), INPPL1(3), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), PTEN(6), RPS6KB1(3) 4325242 78 46 62 11 22 27 4 14 10 1 0.00108 0.347 1.000 56 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6) 1222107 19 16 19 5 3 4 1 11 0 0 0.359 0.362 1.000 57 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(3), ACO2(2), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SDHB(2), SUCLA2(3) 2009728 23 20 23 4 9 4 0 7 3 0 0.0995 0.380 1.000 58 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDK2(2), CDKN1B(1), CKS1B(1), CUL1(7), RB1(4), SKP2(1), TFDP1(4) 1968008 23 18 23 3 4 2 1 11 4 1 0.168 0.392 1.000 59 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(3), CDK2(2), CUL1(7), RB1(4), SKP2(1), TFDP1(4) 2003863 25 19 25 4 6 3 1 11 3 1 0.141 0.397 1.000 60 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(5), GOT2(1), TAT(3) 603127 9 7 9 1 4 3 0 1 1 0 0.180 0.438 1.000 61 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(3), LIPT1(2) 342822 5 4 5 0 0 2 0 2 1 0 0.329 0.441 1.000 62 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(1), CSAD(1), GAD1(7), GAD2(4), GGT1(3) 1251489 18 15 16 4 7 6 1 4 0 0 0.148 0.443 1.000 63 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(4), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(1), CSF2RB(7), IGF1(2), IGF1R(7), IL3(3), KIT(6), KITLG(2), PIK3CA(33), PIK3R1(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2) 4600332 82 49 66 14 26 29 3 17 7 0 0.000628 0.467 1.000 64 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), DUSP10(4), DUSP4(1), GAB1(6), GCK(1), IL1R1(3), MAP2K4(9), MAP2K5(2), MAP3K1(6), MAP3K10(2), MAP3K11(4), MAP3K12(4), MAP3K13(8), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K7(2), MAP3K9(2), MAPK10(4), MAPK7(3), MAPK8(2), MAPK9(3), MYEF2(7), NFATC3(4), NR2C2(4), PAPPA(13), SHC1(3), TP53(76), TRAF6(4), ZAK(4) 11236936 207 102 178 32 74 39 3 46 45 0 3.66e-06 0.515 1.000 65 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCL2(1), BCR(6), CRKL(2), GRB2(2), JAK2(6), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), RAF1(4), SOS1(5), STAT1(6), STAT5B(2) 6072556 96 50 79 14 27 34 8 20 6 1 6.50e-05 0.544 1.000 66 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(5), CARS2(1), CDO1(1), CTH(1), GOT1(5), GOT2(1), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), SDS(2), SULT1B1(3), SULT1C2(1), SULT1C4(3), SULT4A1(1) 2853243 31 20 29 3 13 7 1 7 3 0 0.00690 0.562 1.000 67 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 BTD(2), HLCS(4), SPCS1(1) 690955 7 7 6 2 4 0 0 1 2 0 0.409 0.568 1.000 68 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(4), BMPR1A(4), BMPR1B(9), BMPR2(6) 1398158 23 15 23 4 5 7 0 4 7 0 0.134 0.573 1.000 69 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(2), AASS(7), KARS(3) 1083062 13 10 13 2 4 2 0 5 2 0 0.325 0.594 1.000 70 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(2), GRIA2(10), PPP1R1B(1) 811373 13 11 13 3 6 3 0 3 1 0 0.283 0.600 1.000 71 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(2), HLA-DRA(4), HLA-DRB1(1) 518455 8 8 8 4 2 3 0 1 0 2 0.787 0.604 1.000 72 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1), CD3G(2) 264604 3 2 3 1 1 1 0 0 1 0 0.668 0.615 1.000 73 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), P2RY1(3), P2RY2(2) 1244631 17 14 17 4 7 4 1 4 1 0 0.149 0.620 1.000 74 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 ACAT1(1), CSF1(1), IL6(1), LDLR(4), LPL(6) 1182505 13 10 13 2 3 3 0 5 2 0 0.191 0.637 1.000 75 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(5), NR1I3(2), PTGS1(4), PTGS2(2) 1183825 15 12 15 2 7 4 0 4 0 0 0.124 0.642 1.000 76 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), CDKN1B(1), GRB2(2), ITGB1(6), MAPK1(2), MAPK3(2), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PTEN(6), PTK2(5), SHC1(3), SOS1(5) 4249631 74 45 57 12 13 28 4 19 9 1 0.00539 0.646 1.000 77 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(2), BIRC3(2), CASP8(11), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF2(1) 1909256 20 17 19 4 4 5 2 5 4 0 0.193 0.659 1.000 78 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(5), CTH(1), GOT1(5), GOT2(1), LDHA(1), LDHB(1), LDHC(2) 1540506 16 13 16 2 7 4 0 3 2 0 0.101 0.671 1.000 79 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(2), CBS(2), CTH(1), MUT(3) 1111994 9 8 9 1 4 2 0 0 3 0 0.190 0.680 1.000 80 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT1(1), ACAT2(2), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(3), HADHA(2), SDHB(2), SDS(2) 1755303 17 11 17 1 5 3 0 5 4 0 0.0298 0.694 1.000 81 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), PAK1(4), PDGFRA(13), PIK3CA(33), PIK3R1(5), WASL(5) 2937282 71 38 56 12 14 27 3 18 8 1 0.00920 0.702 1.000 82 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(2), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), FUT8(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2) 1800652 27 19 27 4 14 6 0 5 2 0 0.0406 0.747 1.000 83 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(5), G6PD(2), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GSS(4), GSTA1(1), GSTA3(3), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1), PGD(1) 3947309 54 29 52 7 11 16 2 19 6 0 0.00337 0.748 1.000 84 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), CREB1(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), NFKB1(3), PIK3CA(33), PIK3R1(5), RB1(4), RELA(2), SP1(2) 4304060 72 43 57 11 17 28 4 16 6 1 0.00252 0.762 1.000 85 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 362028 2 2 2 3 0 0 0 1 1 0 0.968 0.766 1.000 86 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP1(1), RANBP2(8), RANGAP1(1) 1709895 10 8 10 1 4 1 1 0 4 0 0.161 0.792 1.000 87 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 80 AIFM1(1), AKT1(2), AKT2(5), APAF1(7), ATM(27), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIRC2(2), BIRC3(2), CAPN1(2), CAPN2(5), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CFLAR(2), CHUK(4), CSF2RB(7), DFFA(2), DFFB(2), FASLG(1), IKBKB(2), IL1A(1), IL1R1(3), IL3(3), IRAK1(1), IRAK2(8), IRAK3(1), IRAK4(2), MAP3K14(2), MYD88(1), NFKB1(3), NFKB2(2), NTRK1(6), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RELA(2), RIPK1(2), TNFRSF10A(3), TNFRSF10B(2), TNFRSF10C(6), TNFRSF1A(1), TNFSF10(1), TP53(76), TRADD(1), TRAF2(1) 18433474 297 126 250 48 90 71 6 74 55 1 8.13e-08 0.799 1.000 88 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1) 1795762 28 17 28 3 12 8 0 8 0 0 0.00726 0.810 1.000 89 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1) 1795762 28 17 28 3 12 8 0 8 0 0 0.00726 0.810 1.000 90 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(2), SUCLA2(3) 469125 5 5 5 2 3 1 0 0 1 0 0.666 0.817 1.000 91 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(2), HADHA(2), SDS(2) 1103642 8 6 8 1 3 2 0 0 3 0 0.194 0.819 1.000 92 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(3), RAB27A(2), RAB3A(2), RAB4A(1), RAB6A(2) 934778 10 8 10 2 3 6 0 1 0 0 0.242 0.827 1.000 93 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(3), EGFR(10), ERBB3(11), NRG1(9), UBE2D1(1) 2334730 34 26 31 6 16 7 0 7 4 0 0.0602 0.847 1.000 94 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), CSF1(1), IL11(1), IL2(3), IL3(3), IL4(3), IL6(1), IL7(1), IL9(1) 1404231 16 12 15 4 7 3 0 5 1 0 0.290 0.854 1.000 95 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), CD3G(2), CD4(2), FYN(4), HLA-DRA(4), HLA-DRB1(1), LCK(2), PTPRC(9), ZAP70(4) 2034223 29 19 29 8 7 10 2 3 5 2 0.219 0.865 1.000 96 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT1(1), ACAT2(2), OXCT1(3) 768566 6 6 6 2 1 1 0 4 0 0 0.738 0.872 1.000 97 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ2(2), COQ6(1), COQ7(1), NDUFA12(2), NDUFA13(1) 909972 7 7 7 2 1 2 0 2 2 0 0.750 0.873 1.000 98 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL4(3), IL5RA(4), IL6(1) 1196015 18 13 18 5 7 3 0 6 0 2 0.398 0.876 1.000 99 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(4), CCNA2(3), CCNE1(3), CCNE2(1), CDK2(2), CDK4(2), CDKN1B(1), CDKN2A(1), E2F2(1), E2F4(1) 1933866 19 16 19 4 6 3 0 9 1 0 0.245 0.877 1.000 100 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), SDS(2) 2745997 36 21 36 4 15 10 0 8 3 0 0.00239 0.891 1.000 101 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(2), HLA-DRA(4), HLA-DRB1(1), IL10(1), IL2(3), IL4(3) 885665 15 12 15 8 6 4 0 3 0 2 0.830 0.891 1.000 102 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST6GALNAC2(1), ST6GALNAC4(1), ST8SIA1(3) 1235086 10 9 10 2 2 2 1 3 2 0 0.272 0.905 1.000 103 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), UGDH(3), UXS1(6) 848425 12 10 12 4 5 3 0 3 1 0 0.624 0.907 1.000 104 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), CREB1(1), GRB2(2), MAPK1(2), MAPK3(2), MAPK7(3), MEF2A(3), MEF2C(7), MEF2D(1), NTRK1(6), PIK3CA(33), PIK3R1(5), PLCG1(4), RPS6KA1(1), SHC1(3) 4074171 75 45 59 14 19 30 3 17 6 0 0.00664 0.907 1.000 105 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(4), FARSA(1), FARSB(7), GOT1(5), GOT2(1), PAH(4), TAT(3), YARS(2), YARS2(3) 1980001 30 18 30 5 10 6 1 8 5 0 0.0756 0.911 1.000 106 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(5), G6PD(2), GCLC(4), GCLM(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GPX6(2), GSR(1), GSS(4), GSTA1(1), GSTA3(3), GSTA5(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), IDH1(3), IDH2(7), MGST1(2), MGST3(1) 4744767 57 30 55 9 11 16 2 21 7 0 0.0105 0.913 1.000 107 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(1), PAPSS2(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SUOX(2) 1360226 9 7 9 1 5 0 0 1 3 0 0.421 0.914 1.000 108 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), GSTZ1(2), HGD(1) 376789 4 3 4 3 0 1 0 2 1 0 0.912 0.918 1.000 109 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(5), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF5(3), GSK3B(7) 2535881 23 17 23 3 6 7 2 3 5 0 0.0736 0.920 1.000 110 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(6), AGT(4), AGTR1(3), AGTR2(4), COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), REN(3) 5601828 78 38 77 14 17 23 2 22 14 0 0.00240 0.926 1.000 111 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(6), APOBEC1(2), APOBEC2(1), APOBEC3A(1), APOBEC3C(3), APOBEC3F(1), APOBEC3G(2), APOBEC4(2) 1623570 18 14 18 3 7 4 0 5 2 0 0.163 0.932 1.000 112 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(4), AGTR1(3), AGTR2(4), BDKRB2(2), KNG1(3), NOS3(2), REN(3) 2185770 23 19 23 5 8 5 0 6 4 0 0.212 0.936 1.000 113 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(2), ACOX1(3), ACOX3(5), ELOVL2(3), ELOVL5(1), ELOVL6(1), FADS2(3), FASN(1), HADHA(2), HSD17B12(2), SCD(2) 3268162 25 19 25 4 11 6 1 4 3 0 0.0395 0.936 1.000 114 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(4), PLCD1(6), PRKCA(2), TGM2(4) 1123653 16 11 16 4 6 2 1 6 1 0 0.376 0.938 1.000 115 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(4), ACO1(3), ACO2(2), ACSS1(3), ACSS2(5), FH(1), IDH1(3), IDH2(7), MDH1(1), MDH2(1), SUCLA2(3) 3002331 33 23 33 6 15 7 0 8 3 0 0.0371 0.947 1.000 116 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYA(1), NFYB(1), NFYC(3), RB1(4), SP1(2), SP3(2) 1523822 13 11 13 3 2 4 1 5 0 1 0.435 0.949 1.000 117 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), FH(1), IDH2(7), MDH1(1), OGDH(4), SDHA(5), SUCLA2(3) 2074997 23 20 23 6 11 4 0 4 4 0 0.193 0.950 1.000 118 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 CDK5R1(1), EGR1(2), KLK2(3), MAP2K1(3), MAPK1(2), MAPK3(2), NGFR(2), RAF1(4) 1770667 19 16 16 5 6 3 2 5 3 0 0.220 0.953 1.000 119 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), CTSD(3), ESR1(12), GREB1(10), HSPB2(1), MTA1(1), PDZK1(1), TUBA8(1) 2300238 30 18 30 8 10 6 0 9 5 0 0.235 0.965 1.000 120 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(2), ACAT1(1), ACAT2(2), ECHS1(2), EHHADH(2), HADHA(2), HADHB(1), SDS(2) 1899856 14 10 14 2 3 5 0 3 3 0 0.133 0.965 1.000 121 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(1), IFNAR1(3), IFNAR2(1), IFNB1(1), JAK1(3), STAT1(6), STAT2(5), TYK2(1) 2364117 21 16 20 4 10 3 1 5 2 0 0.146 0.966 1.000 122 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(2), B3GALT1(1), B3GALT2(3), B3GALT5(2), B3GNT5(1), FUT1(1), FUT2(1), FUT3(3), ST3GAL3(4), ST3GAL4(2) 1551761 20 13 20 3 9 4 0 5 2 0 0.0807 0.967 1.000 123 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), UGDH(3), UGP2(5), UXS1(6) 1088716 17 14 17 5 7 4 0 4 2 0 0.531 0.968 1.000 124 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHRNB1(3), CHRNG(2), MUSK(2), PIK3CA(33), PIK3R1(5), PTK2(5), PTK2B(1), RAPSN(2), SRC(3), TERT(2) 3527856 61 44 46 15 14 25 2 11 9 0 0.0770 0.968 1.000 125 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(5), BPNT1(1), GRB2(2), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3CD(2), PTEN(6), PTK2B(1), RBL2(8), SHC1(3), SOS1(5) 4488345 72 42 55 12 16 26 4 17 8 1 0.00782 0.968 1.000 126 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(3), BFAR(1), BRAF(21), CREB1(1), CREB3(2), CREB5(2), MAPK1(2), RAF1(4), SNX13(6), SRC(3), TERF2IP(1) 2516959 46 32 27 11 7 8 0 26 5 0 0.385 0.969 1.000 127 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 ANP32A(1), APEX1(2), CREBBP(21), DFFA(2), DFFB(2), GZMA(2), GZMB(1), HMGB2(1) 2291316 32 22 32 8 7 13 1 5 6 0 0.191 0.969 1.000 128 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(5), LARS(4), LARS2(2), PDHA1(4), PDHA2(6), PDHB(2) 2239541 24 15 24 4 9 6 0 5 4 0 0.139 0.969 1.000 129 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BAD(1), BAX(1), BCL2(1), CASP8(11), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), NFKB1(3), NSMAF(1), RAF1(4), RELA(2), RIPK1(2), SMPD1(6), TNFRSF1A(1), TRADD(1), TRAF2(1) 4586695 59 37 56 10 22 16 4 9 8 0 0.00593 0.970 1.000 130 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(7), BAD(1), BAK1(1), BAX(1), BCL10(3), BCL2(1), BCL2L1(1), BCL2L11(2), BID(1), CASP8AP2(12), CASP9(2), CES1(4) 2317879 36 21 36 8 11 5 0 13 7 0 0.339 0.971 1.000 131 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(3), ACAT1(1), ECHS1(2), HADHA(2) 1223515 8 6 8 2 0 2 0 2 4 0 0.533 0.973 1.000 132 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(3) 404894 3 3 3 2 2 0 0 0 1 0 0.832 0.974 1.000 133 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(1), AOC2(4), AOC3(4), CES1(4) 1262730 13 12 13 4 6 3 0 4 0 0 0.476 0.975 1.000 134 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(3), GNAQ(3), GNB1(1), HTR2C(6), PLCB1(8), TUB(4) 1610088 25 18 25 7 13 3 1 5 3 0 0.353 0.978 1.000 135 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(121), APC2(1), AXIN1(1), AXIN2(7), BTRC(2), CACYBP(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CCND2(1), CCND3(1), CER1(3), CHD8(4), CREBBP(21), CSNK1A1(2), CSNK1A1L(5), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(8), CTNNBIP1(1), CUL1(7), CXXC4(1), DAAM1(1), DAAM2(5), DKK1(3), DKK2(5), DKK4(4), DVL2(8), DVL3(2), EP300(13), FBXW11(7), FZD10(4), FZD2(2), FZD3(10), FZD4(1), FZD6(3), FZD7(3), FZD8(1), GSK3B(7), LEF1(4), LRP5(5), LRP6(10), MAP3K7(2), MAPK10(4), MAPK8(2), MAPK9(3), MMP7(3), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NKD1(3), NKD2(1), NLK(1), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PORCN(2), PPARD(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRICKLE1(8), PRICKLE2(5), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PSEN1(3), RHOA(4), ROCK1(8), ROCK2(2), RUVBL1(6), SENP2(2), SFRP1(2), SFRP2(1), SFRP4(3), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(11), SMAD3(6), SMAD4(21), SOX17(2), TBL1X(5), TBL1XR1(6), TCF7(3), TCF7L1(3), TCF7L2(13), TP53(76), VANGL1(2), VANGL2(5), WIF1(2), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1) 35362156 630 149 557 121 206 110 8 124 147 35 1.02e-12 0.978 1.000 136 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(4), MDH1(1), ME1(7), PC(3), PDHA1(4), SLC25A11(1) 2044170 20 19 20 5 8 5 0 3 4 0 0.252 0.979 1.000 137 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 BCL2(1), CREBBP(21), EP300(13), FYN(4), IL7(1), IL7R(2), JAK1(3), JAK3(6), LCK(2), NMI(1), PIK3CA(33), PIK3R1(5), PTK2B(1), STAT5B(2) 6206346 95 53 79 21 25 37 3 18 12 0 0.00923 0.981 1.000 138 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(5), BCL10(3), BTK(6), CARD11(6), CD19(3), CD22(8), CD72(3), CD79A(3), CHUK(4), CR2(9), GSK3B(7), IFITM1(1), IKBKB(2), INPP5D(2), KRAS(58), LILRB3(1), LYN(4), MALT1(6), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NRAS(15), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PTPN6(4), RASGRP3(4), VAV1(11), VAV2(2), VAV3(10) 16271621 279 108 204 47 81 83 5 90 20 0 1.20e-08 0.982 1.000 139 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 APAF1(7), ARHGAP5(6), ARHGDIB(3), CASP1(2), CASP10(2), CASP3(1), CASP8(11), CASP9(2), GZMB(1) 2840049 35 26 33 9 5 7 1 12 10 0 0.437 0.983 1.000 140 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), GPD2(3), NDUFA1(1), SDHA(5), SDHB(2), SDHD(1), UQCRC1(2) 1435781 16 11 16 3 5 5 0 5 1 0 0.246 0.983 1.000 141 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), MIOX(1), UGDH(3) 1906422 24 17 24 5 9 7 0 6 2 0 0.123 0.983 1.000 142 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(2), CAPNS1(1), CAPNS2(1), CDK5R1(1), CSNK1A1(2), CSNK1D(3), GSK3B(7), MAPT(4), PPP2CA(1) 1910225 22 14 22 4 9 6 0 4 3 0 0.0903 0.984 1.000 143 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(5), BTK(6), FCER1A(2), FYN(4), GAB2(1), GRB2(2), IL13(1), IL3(3), IL4(3), INPP5D(2), KRAS(58), LCP2(2), LYN(4), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK9(3), MS4A2(1), NRAS(15), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCG1(4), PLCG2(9), PRKCA(2), PRKCD(3), PRKCE(4), RAF1(4), SOS1(5), SOS2(9), VAV1(11), VAV2(2), VAV3(10) 15938701 273 107 195 44 69 91 9 89 15 0 1.42e-08 0.985 1.000 144 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(3), GGT1(3), SHMT1(1), SHMT2(2) 818886 9 9 7 4 2 4 0 0 3 0 0.652 0.986 1.000 145 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(3), ENO3(3), FARS2(4), GOT1(5), GOT2(1), PAH(4), TAT(3), YARS(2) 1897118 25 17 25 5 8 8 0 6 3 0 0.151 0.987 1.000 146 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(6), ERBB4(16), NRG2(4), NRG3(3), PRKCA(2), PSEN1(3) 2052435 34 22 34 8 7 10 0 13 4 0 0.201 0.988 1.000 147 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(5), ALAS2(5), FECH(2), HMBS(2), PPOX(3), UROS(1) 1741135 18 12 18 3 10 3 0 4 1 0 0.215 0.988 1.000 148 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), CPS1(8), GLUD1(2), GOT1(5) 1712784 16 10 16 4 4 5 0 4 3 0 0.383 0.988 1.000 149 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 CXCL12(1), CXCR4(3), GNAI1(3), GNAQ(3), GNB1(1), MAP2K1(3), MAPK1(2), MAPK3(2), NFKB1(3), PIK3C2G(7), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(5), PTK2B(1), RAF1(4), RELA(2) 6027101 84 51 68 15 25 29 3 16 11 0 0.00247 0.989 1.000 150 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), ARSB(5), ARSD(3), ARSE(2), CYP11B1(5), CYP11B2(5), HSD11B1(1), HSD17B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), SRD5A1(1), SRD5A2(1), STS(6), SULT1E1(1), SULT2A1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2) 5925537 57 29 57 8 29 10 1 10 7 0 0.000822 0.989 1.000 151 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 CSNK2A1(4), GRB2(2), INSR(5), IRS1(5), MAP2K1(3), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), PTPN11(2), RAF1(4), RASA1(5), SHC1(3), SLC2A4(3), SOS1(5), SRF(3) 5599683 86 49 69 17 17 33 4 25 7 0 0.00802 0.990 1.000 152 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3D(1), CD3G(2), CD4(2) 637625 7 6 8 5 2 4 0 0 1 0 0.837 0.990 1.000 153 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 ADAM17(6), DLL1(1), FURIN(2), PSEN1(3) 2031047 12 10 12 2 5 4 0 0 3 0 0.0801 0.990 1.000 154 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(12), ESR2(2), PDE1A(3), PDE1B(2), PLCB1(8), PLCB2(3), PRL(2), TRH(1) 2492766 33 20 33 8 13 9 0 7 4 0 0.155 0.991 1.000 155 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(3), CD3D(1), CD3G(2), GZMB(1), HLA-A(1), ICAM1(2), ITGAL(5), ITGB2(4) 1865817 19 14 19 5 5 5 0 3 6 0 0.355 0.992 1.000 156 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 APAF1(7), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BID(1), BIK(1), BIRC2(2), BIRC3(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), DFFA(2), DFFB(2), DIABLO(1) 3086246 38 27 37 8 9 10 1 12 6 0 0.158 0.992 1.000 157 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(21), CPEB1(2), EGFR(10), ERBB2(6), ERBB4(16), ETS2(2), ETV6(4), FMN2(4), GRB2(2), KRAS(58), MAP2K1(3), MAPK1(2), MAPK3(2), NOTCH2(11), NOTCH3(12), NOTCH4(3), PIWIL1(5), PIWIL2(6), PIWIL3(8), PIWIL4(6), RAF1(4), SOS1(5), SOS2(9), SPIRE1(2), SPIRE2(1) 11829901 204 101 134 41 42 63 3 89 7 0 0.000260 0.993 1.000 158 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(2), ARG1(1), GLUD1(2) 1200939 5 5 5 2 3 2 0 0 0 0 0.572 0.993 1.000 159 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(2), CHST12(2), CHST13(1), PAPSS1(1), PAPSS2(2), SULT1A1(2), SULT1A2(1), SULT1E1(1), SULT2A1(1), SULT2B1(1), SUOX(2) 2058680 17 11 17 3 9 2 0 3 3 0 0.203 0.994 1.000 160 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(4), CCNB1(2), CCND2(1), CCND3(1), CCNE1(3), CCNH(2), CDC25A(2), CDK2(2), CDK4(2), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), RB1(4), RBL1(3), TFDP1(4) 3556888 36 26 36 9 11 7 1 13 3 1 0.255 0.994 1.000 161 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(2), ITGAL(5), ITGAM(5), ITGB2(4), PECAM1(1), SELE(2) 2175968 22 16 22 6 8 8 0 4 2 0 0.239 0.995 1.000 162 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CSF1(1), MST1(1), MST1R(1) 1353394 3 3 3 1 1 1 0 1 0 0 0.673 0.995 1.000 163 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(2), IDI1(1), SQLE(1) 668762 4 4 4 3 1 2 0 0 1 0 0.877 0.995 1.000 164 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), NFS1(2), PHPT1(1), THTPA(1) 1446428 14 12 14 4 4 3 1 4 2 0 0.472 0.995 1.000 165 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(6), AGT(4), AGTR1(3), AGTR2(4), ANPEP(5), CPA3(2), CTSA(3), CTSG(2), ENPEP(7), LNPEP(6), MAS1(1), MME(6), NLN(1), REN(3) 4768085 55 35 55 10 14 17 2 14 8 0 0.0226 0.995 1.000 166 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), P4HB(2), SLC23A1(2), SLC23A2(6), SLC2A3(1) 5523661 69 34 68 15 16 17 2 20 14 0 0.0162 0.996 1.000 167 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(1), ALPP(1), GGH(1) 1349931 5 5 5 1 2 1 1 1 0 0 0.378 0.996 1.000 168 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTA1(3), ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), WASF1(1), WASL(5) 1796016 20 15 20 5 7 5 1 6 1 0 0.232 0.996 1.000 169 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(6), DIAPH1(1), FYN(4), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), MYL2(1), MYLK(11), PIK3CA(33), PIK3R1(5), PTK2(5), RAF1(4), ROCK1(8), SHC1(3), SRC(3), TLN1(5) 8237069 105 60 87 20 26 37 3 25 14 0 0.00483 0.996 1.000 170 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1) 2899221 40 26 40 10 12 11 1 16 0 0 0.130 0.996 1.000 171 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(2), IDI1(1), IDI2(1), SQLE(1) 915665 5 5 5 4 1 2 0 0 2 0 0.899 0.996 1.000 172 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP3(1), CASP7(1), DFFA(2), DFFB(2), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(5) 1837518 16 12 15 4 3 4 0 8 1 0 0.541 0.996 1.000 173 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), CDKN1A(1), GRIN1(1), HIF1A(1), JAK2(6), NFKB1(3), RELA(2), SOD2(4) 2860971 22 18 22 5 6 6 1 6 2 1 0.261 0.996 1.000 174 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(2), IFNGR2(1), JAK1(3), JAK2(6), STAT1(6) 1826904 19 13 18 6 7 1 2 7 1 1 0.571 0.997 1.000 175 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(2), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C4(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(1), SOAT2(1), SRD5A1(1), SRD5A2(1) 5165787 65 33 65 11 20 18 1 23 3 0 0.00446 0.997 1.000 176 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A2(4), EIF4G1(8), EIF4G2(7), EIF4G3(8), GHR(6), IRS1(5), MAPK1(2), MAPK14(3), MAPK3(2), MKNK1(1), PABPC1(3), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PRKCA(2), PTEN(6), RPS6KB1(3) 6184295 102 53 85 17 22 36 2 31 10 1 0.00209 0.997 1.000 177 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP14(4), MMP2(2), MMP9(6), RECK(3), TIMP1(1), TIMP2(2), TIMP3(2), TIMP4(2) 1680448 22 16 22 5 13 3 2 4 0 0 0.110 0.997 1.000 178 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(2), HADHB(1), HSD17B10(1), HSD17B4(3), MECR(1), PPT2(1) 1943597 12 10 12 5 2 2 0 3 5 0 0.741 0.997 1.000 179 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(6), FCER1A(2), GRB2(2), LYN(4), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PAK2(2), PIK3CA(33), PIK3R1(5), PLA2G4A(5), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), RAF1(4), SHC1(3), SOS1(5), SYT1(1), VAV1(11) 9487473 131 64 113 23 40 41 7 28 15 0 0.000106 0.997 1.000 180 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(4), AKT1(2), ASAH1(3), GNAI1(3), GNB1(1), ITGAV(1), ITGB3(7), MAPK1(2), MAPK3(2), PDGFA(1), PDGFRA(13), PIK3CA(33), PIK3R1(5), PLCB1(8), PRKCA(2), PTK2(5), SMPD1(6), SRC(3) 6083729 101 50 86 24 27 36 4 24 9 1 0.0266 0.998 1.000 181 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT1(1), ACAT2(2), BDH1(1), HMGCS1(1), OXCT1(3), OXCT2(1) 1645105 9 8 9 3 4 1 0 4 0 0 0.673 0.998 1.000 182 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(7), GRB2(2), IL3(3), JAK2(6), MAP2K1(3), MAPK3(2), PTPN6(4), RAF1(4), SHC1(3), SOS1(5), STAT5B(2) 3721974 41 24 38 9 17 7 4 8 4 1 0.121 0.998 1.000 183 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 APAF1(7), BAD(1), BAK1(1), BAX(1), BCL2(1), BCL2L1(1), BCL2L11(2), BID(1), BIRC2(2), BIRC3(2), BNIP3L(3), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CHUK(4), DFFA(2), DFFB(2), FASLG(1), GZMB(1), HELLS(4), IKBKB(2), IRF1(1), IRF2(3), IRF4(1), IRF5(3), IRF6(2), MAP2K4(9), MAP3K1(6), MAPK10(4), MDM2(4), NFKB1(3), NFKBIB(1), NFKBIE(2), RELA(2), RIPK1(2), TNFRSF10B(2), TNFRSF1A(1), TNFRSF21(4), TNFSF10(1), TP53(76), TRADD(1), TRAF1(1), TRAF2(1), TRAF3(4) 12777901 197 103 169 37 63 42 4 46 42 0 0.000329 0.998 1.000 184 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 A4GALT(3), B3GALNT1(3), B3GALT5(2), FUT1(1), FUT2(1), FUT9(4), GLA(4), HEXB(1), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST8SIA1(3) 2375681 25 16 25 8 8 6 0 6 5 0 0.402 0.998 1.000 185 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(2), F13B(3), HSD17B2(1), HSD17B3(1), HSD17B4(3), HSD3B1(2) 1833742 12 8 12 2 4 4 0 3 1 0 0.200 0.998 1.000 186 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 EPHX2(1), HSD3B7(2), RDH12(2), RDH13(1) 1062709 6 5 6 3 3 1 0 2 0 0 0.729 0.998 1.000 187 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), EGF(3), EGFR(10), GRB2(2), JAK1(3), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3), STAT1(6), STAT3(2) 8271343 116 58 97 22 34 39 6 28 9 0 0.00128 0.998 1.000 188 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(4), ARHGEF1(4), F2(2), GNA12(2), GNA13(2), GNAI1(3), GNAQ(3), GNB1(1), MAP3K7(2), PIK3CA(33), PIK3R1(5), PLCB1(8), PPP1R12B(5), PRKCA(2), PTK2B(1), ROCK1(8) 5751457 85 47 69 18 21 26 3 25 10 0 0.0308 0.998 1.000 189 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 AKT1(2), GNAS(6), GNB1(1), NFKB1(3), NOS3(2), NPPA(1), NR3C1(3), PIK3CA(33), PIK3R1(5), RELA(2), SYT1(1) 3925358 59 44 44 14 14 21 3 15 6 0 0.144 0.998 1.000 190 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTA1(3), ACTR2(1), ACTR3(2), ARPC1A(5), ARPC1B(2), ARPC2(1), NCKAP1(8), NTRK1(6), WASF1(1), WASF2(2), WASF3(2), WASL(5) 3418143 38 24 38 9 12 9 2 11 4 0 0.135 0.998 1.000 191 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), BCAT2(1), IARS(5), IARS2(6), ILVBL(2), LARS(4), LARS2(2), PDHA1(4), PDHA2(6), PDHB(2), VARS(1), VARS2(6) 4129187 40 25 40 8 18 10 0 6 6 0 0.114 0.998 1.000 192 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(2), FUT1(1), FUT2(1), FUT3(3), FUT6(1), ST3GAL3(4) 1017104 12 9 12 4 7 2 0 3 0 0 0.403 0.998 1.000 193 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(3), CHRNA1(2), SNAP25(1), STX1A(2) 725512 8 8 8 4 6 1 0 1 0 0 0.818 0.998 1.000 194 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA3(3), GGT1(3), SHMT1(1), SHMT2(2) 1133874 9 9 7 6 2 4 0 0 3 0 0.875 0.998 1.000 195 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(2), CDK5R1(1), CFL1(1), CHN1(1), LIMK1(4), MAP3K1(6), MYL2(1), MYLK(11), NCF2(1), PAK1(4), PDGFRA(13), PIK3CA(33), PIK3R1(5), PLD1(8), PPP1R12B(5), RALBP1(4), RPS6KB1(3), TRIO(12), VAV1(11), WASF1(1) 7659035 127 58 111 29 36 45 4 24 17 1 0.00647 0.999 1.000 196 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 DUSP1(2), GORASP1(3), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MAPKAPK5(1), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CA(33), PIK3CD(2), PIK3R1(5), SYT1(1), TRAF2(1), TRAF3(4), TRAF5(4), TRAF6(4) 7369986 98 57 82 20 22 33 2 29 12 0 0.0116 0.999 1.000 197 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 A4GALT(3), FUT1(1), FUT2(1), FUT9(4), GLA(4), HEXB(1), NAGA(1), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), ST8SIA1(3) 2233567 22 15 22 8 5 6 0 6 5 0 0.518 0.999 1.000 198 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(3), CYSLTR2(3), GPR161(5), GPR171(3), GPR34(5), GPR39(2), GPR45(4), GPR75(1) 2149154 26 17 26 9 12 4 1 7 2 0 0.428 0.999 1.000 199 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSR(1), GSS(4), NFKB1(3), NOX1(1), RELA(2), XDH(7) 2266730 19 15 19 6 5 7 1 3 3 0 0.426 0.999 1.000 200 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 FLT3(3), IGF1(2), IL11(1), IL1A(1), IL3(3), IL6(1), IL9(1), KITLG(2), TGFB1(1), TGFB2(5) 1892886 20 16 19 8 8 1 0 8 3 0 0.754 0.999 1.000 201 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3D(1), CD3G(2), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9) 2381201 27 17 27 9 6 10 0 6 5 0 0.383 0.999 1.000 202 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(2), ITGA4(3), ITGAL(5), ITGB1(6), ITGB2(4), PECAM1(1), SELE(2) 2634129 26 18 25 8 8 9 0 7 2 0 0.334 0.999 1.000 203 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(3), ACOX3(5), FADS2(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2) 2322450 20 13 20 6 8 5 1 4 2 0 0.374 0.999 1.000 204 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(1), LPL(6), NR3C1(3), PPARG(1), RXRA(1) 1291202 12 8 12 9 1 2 0 7 2 0 0.982 0.999 1.000 205 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 CSNK2A1(4), GRB2(2), JAK1(3), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), PDGFA(1), PDGFRA(13), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SRF(3), STAT1(6), STAT3(2) 7647548 117 56 98 23 29 41 7 27 12 1 0.00239 0.999 1.000 206 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(21), EP300(13), ESR1(12), MAPK1(2), MAPK3(2), PELP1(2), SRC(3) 3235092 55 34 55 13 18 20 1 9 7 0 0.0520 0.999 1.000 207 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(7), CR2(9), HLA-DRA(4), HLA-DRB1(1), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9) 3152131 41 24 41 10 11 14 0 9 5 2 0.165 0.999 1.000 208 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 13 DHRS1(1), DHRS2(2), DHRS3(2), HSD3B7(2), PON1(5), PON2(1), PON3(2), RDH12(2), RDH13(1) 1868524 18 14 18 7 7 3 1 3 4 0 0.621 0.999 1.000 209 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(4), PRKCA(2), PTK2B(1) 1516865 9 8 9 3 4 1 1 2 1 0 0.592 0.999 1.000 210 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(4), AKT1(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB1(1), GNAS(6), GRB2(2), MAPK1(2), MAPK14(3), MAPK3(2), PIK3CA(33), PIK3R1(5), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RPS6KA1(1), RPS6KA5(3), SOS1(5) 6390909 85 51 70 21 22 28 7 24 4 0 0.0478 0.999 1.000 211 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1) 3015524 22 12 22 3 7 8 1 5 1 0 0.0468 1.000 1.000 212 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(3), DAG1(4), GNAQ(3), ITPKB(4) 1350658 14 10 14 5 5 3 2 2 2 0 0.523 1.000 1.000 213 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), XDH(7) 1762882 23 15 23 9 6 7 1 6 3 0 0.614 1.000 1.000 214 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(3), CD34(1), CD3D(1), CD3G(2), CD4(2), CD58(1), IL3(3), IL6(1), KITLG(2) 1434724 16 10 15 6 5 6 0 4 1 0 0.474 1.000 1.000 215 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), CD36(1), FYN(4), MAPK14(3), THBS1(8) 1616433 17 14 17 7 5 6 0 4 2 0 0.568 1.000 1.000 216 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3D(1), CD3G(2), IFNG(1), IL2(3), IL2RA(2), IL4(3), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TGFBR3(5), TOB2(1) 2393819 38 21 37 13 16 6 1 9 6 0 0.528 1.000 1.000 217 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(1), CNR1(3), DNMT1(12), MTNR1B(3), PTAFR(1), PTGER2(1), PTGFR(6), PTGIR(1) 2481909 28 19 25 7 11 3 1 12 1 0 0.187 1.000 1.000 218 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), GRB2(2), HBXIP(2), PTK2B(1), SHC1(3), SOS1(5), SRC(3) 1984301 17 15 16 6 2 4 2 6 3 0 0.701 1.000 1.000 219 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 27 AKT1(2), AKT2(5), BAD(1), BCL2(1), GRB2(2), GSK3A(2), GSK3B(7), IL4R(1), IRS1(5), JAK1(3), JAK3(6), MAP4K1(2), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3CD(2), PIK3R1(5), PPP1R13B(5), RAF1(4), SHC1(3), SOS1(5), SOS2(9), STAT6(2) 8056699 109 55 91 21 29 35 4 27 14 0 0.00200 1.000 1.000 220 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(3), EGFR(10), TF(7), TFRC(2) 2936137 27 18 27 6 14 4 1 5 2 1 0.108 1.000 1.000 221 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(27), BUB1(4), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDAN1(1), CDC14A(1), CDC14B(3), CDC20(3), CDC25A(2), CDC25B(5), CDC25C(3), CDC7(2), CDH1(4), CDK2(2), CDK4(2), CDKN1A(1), CDKN2A(1), CHEK1(1), CHEK2(1), DTX4(3), E2F2(1), E2F3(1), E2F4(1), E2F5(2), EP300(13), ESPL1(8), GSK3B(7), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(1), HDAC6(4), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), MPEG1(2), MPL(1), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PLK1(6), PRKDC(13), PTPRA(2), PTTG1(1), RB1(4), RBL1(3), SKP2(1), SMAD4(21), TBC1D8(5), TFDP1(4), TGFB1(1), TP53(76), WEE1(3) 24214183 316 122 286 54 91 80 4 77 61 3 1.54e-07 1.000 1.000 222 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(5), ALAS2(5), CPO(3), FECH(2), GATA1(4), HBB(2), HMBS(2), UROS(1) 1843363 24 14 24 5 13 5 0 5 1 0 0.187 1.000 1.000 223 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 CREB1(1), KEAP1(3), MAPK1(2), MAPK14(3), MAPK8(2), NFE2L2(1), PRKCA(2) 1900952 14 9 14 3 2 5 0 7 0 0 0.301 1.000 1.000 224 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(2), AASS(7), KARS(3) 1589309 16 12 16 5 5 3 0 6 2 0 0.604 1.000 1.000 225 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(7), CLOCK(5), CRY1(2), CRY2(1), PER1(1) 1919112 16 10 16 4 7 2 0 5 2 0 0.387 1.000 1.000 226 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMB9(4) 1986367 17 14 17 6 6 3 2 3 3 0 0.472 1.000 1.000 227 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 ACTA1(3), EPHA4(4), EPHB1(6), FYN(4), ITGA1(3), ITGB1(6), L1CAM(2), LYN(4), RAP1B(2), SELP(4) 3359665 38 23 38 8 14 12 0 9 3 0 0.0498 1.000 1.000 228 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), HLA-DRA(4), HLA-DRB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL18R1(8), IL2(3), IL2RA(2), IL4(3), IL4R(1) 2794337 36 22 36 13 12 10 0 10 2 2 0.471 1.000 1.000 229 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4) 2789840 38 23 38 11 12 9 0 12 4 1 0.310 1.000 1.000 230 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5), PNPO(1), PSAT1(3) 1099626 9 8 9 5 4 4 0 0 1 0 0.753 1.000 1.000 231 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(2), CREB1(1), CREBBP(21), EP300(13), NCOA3(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RXRA(1) 4577703 51 31 51 12 15 20 2 8 6 0 0.0564 1.000 1.000 232 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 CSNK2A1(4), GRB2(2), JAK2(6), MAP2K1(3), MAPK3(2), MPL(1), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), RAF1(4), RASA1(5), SHC1(3), SOS1(5), STAT1(6), STAT3(2), STAT5B(2), THPO(1) 6652916 90 48 73 18 21 30 6 24 8 1 0.0133 1.000 1.000 233 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 AKT1(2), AKT2(5), BAD(1), BTK(6), CDKN2A(1), DAPP1(1), GRB2(2), GSK3A(2), GSK3B(7), IARS(5), IGFBP1(2), INPP5D(2), PIK3CA(33), PPP1R13B(5), PTEN(6), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SHC1(3), SOS1(5), SOS2(9), TEC(1), YWHAB(2), YWHAE(3), YWHAQ(1) 7852143 119 51 102 22 32 36 4 32 14 1 0.00201 1.000 1.000 234 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(1), ANKRD1(4), ATF3(1), CYR61(2), HBEGF(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(3), NR4A3(2), WDR1(3) 2377427 21 13 21 5 5 9 0 5 2 0 0.280 1.000 1.000 235 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(4), IL13(1), IL4(3), MAF(1), MAP2K3(2), MAPK14(3), NFATC1(1), NFATC2(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2) 2618276 25 18 25 7 15 2 2 4 2 0 0.122 1.000 1.000 236 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(1), GOT1(5), GOT2(1), TAT(3), TYR(2) 1070358 12 10 12 5 5 3 0 3 1 0 0.686 1.000 1.000 237 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(2), BIRC2(2), BIRC3(2), CASP3(1), CASP8(11), CFLAR(2), MAP2K4(9), MAP3K3(2), MAP3K7(2), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NR2C2(4), RALBP1(4), RIPK1(2), TNFAIP3(2), TNFRSF1A(1), TRADD(1), TRAF2(1) 6066199 56 32 54 10 15 16 3 16 6 0 0.0235 1.000 1.000 238 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(2), B3GNT1(2), B3GNT2(1), B3GNT4(1), B3GNT5(1), B4GALT1(5), B4GALT2(3), B4GALT3(6), FUT1(1), FUT2(1), FUT3(3), FUT6(1), FUT9(4), GCNT2(9), ST3GAL6(4), ST8SIA1(3) 3481722 47 27 47 10 20 8 2 13 4 0 0.0440 1.000 1.000 239 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(3), ACO2(2), HAO1(5), HAO2(3), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6) 2880626 28 17 27 8 11 5 0 10 2 0 0.265 1.000 1.000 240 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), CREM(4), MAPK3(2), OPRK1(5), POLR2A(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2) 2802941 25 18 25 5 12 6 1 5 1 0 0.0664 1.000 1.000 241 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(4), EIF4B(1), EIF4G1(8), EIF4G2(7), EIF4G3(8), MKNK1(1), PDK2(1), PDPK1(1), PIK3CA(33), PIK3R1(5), PPP2CA(1), PTEN(6), RPS6KB1(3), TSC1(3), TSC2(1) 6051648 85 46 68 18 20 33 2 19 10 1 0.0204 1.000 1.000 242 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(2), ACP2(2), ACP5(1), ACPP(3), ALPI(2), ALPL(1), ALPP(1), CYP19A1(5), CYP1A1(6), CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), CYP4B1(8), CYP4F8(4), CYP51A1(3), PON1(5) 6342650 88 43 87 18 32 18 4 24 9 1 0.00792 1.000 1.000 243 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 125 ARAF(3), BID(1), BRAF(21), CASP3(1), CD244(3), CD247(2), FASLG(1), FYN(4), GRB2(2), GZMB(1), HLA-A(1), HLA-B(3), HLA-C(2), HLA-E(1), HLA-G(1), ICAM1(2), ICAM2(1), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), ITGAL(5), ITGB2(4), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(3), KIR3DL2(3), KLRC3(2), KLRD1(1), KLRK1(3), KRAS(58), LCK(2), LCP2(2), MAP2K1(3), MAPK1(2), MAPK3(2), MICB(1), NCR1(1), NCR3(1), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NRAS(15), PAK1(4), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(8), PTK2B(1), PTPN11(2), PTPN6(4), RAF1(4), SH2D1A(2), SH2D1B(1), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), TNFRSF10A(3), TNFRSF10B(2), TNFRSF10C(6), TNFSF10(1), ULBP1(2), ULBP2(2), VAV1(11), VAV2(2), VAV3(10), ZAP70(4) 24991467 382 117 282 70 88 109 11 142 30 2 2.36e-08 1.000 1.000 244 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA1(1), NDUFA10(2), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFV1(2) 1558178 12 10 12 4 4 3 0 4 1 0 0.579 1.000 1.000 245 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(5), POLR3GL(1), POLR3H(1) 5220241 46 27 46 9 17 16 1 9 3 0 0.0302 1.000 1.000 246 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(4), EIF2B1(2), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), ELAVL1(3), FLT1(9), FLT4(4), HIF1A(1), KDR(8), NOS3(2), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), PTK2(5), SHC1(3) 7536297 94 52 78 22 24 34 3 22 11 0 0.0333 1.000 1.000 247 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(5), BAD(1), CASP9(2), KDR(8), KRAS(58), MAP2K1(3), MAPK1(2), MAPK12(2), MAPK14(3), MAPK3(2), MAPKAPK2(3), MAPKAPK3(1), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NOS3(2), NRAS(15), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCG1(4), PLCG2(9), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCA(2), PRKCG(8), PTGS2(2), PTK2(5), RAF1(4), SH2D2A(1), SPHK2(1), SRC(3), VEGFA(2) 16016243 242 105 167 48 67 76 4 76 19 0 1.07e-05 1.000 1.000 248 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(3), IFNB1(1), JAK1(3), PTPRU(6), REG1A(3), STAT1(6), STAT2(5), TYK2(1) 2740551 28 19 26 7 13 6 1 5 3 0 0.191 1.000 1.000 249 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(3), ACO2(2), HAO1(5), HAO2(3), HYI(1), MDH1(1), MDH2(1), MTHFD1(6), MTHFD1L(6) 3016656 28 17 27 8 11 5 0 10 2 0 0.256 1.000 1.000 250 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(6), PARK2(4), SNCA(1), SNCAIP(1), UBE2F(1), UBE2G1(2), UBE2L3(2) 1446518 17 13 17 7 5 5 0 6 1 0 0.653 1.000 1.000 251 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15B(5), ALOX5(4), ALOX5AP(1), DPEP1(1), GGT1(3), PLA2G6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5) 3353141 33 21 31 9 11 9 0 12 1 0 0.212 1.000 1.000 252 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(7), CLOCK(5), CRY1(2), CRY2(1), CSNK1D(3), NPAS2(5), NR1D1(4), PER1(1), PER2(2), PER3(7) 3828144 37 22 36 8 18 7 0 10 2 0 0.0644 1.000 1.000 253 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(1), IFNGR1(2), JAK1(3), JAK2(6), PTPRU(6), REG1A(3), STAT1(6) 2526750 27 16 25 9 11 4 2 7 2 1 0.527 1.000 1.000 254 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 GNAQ(3), NFKB1(3), PLCB1(8), PRKCA(2), RELA(2) 1879629 18 14 18 5 6 3 0 6 3 0 0.492 1.000 1.000 255 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(14), ACACB(14), FASN(1), MCAT(1), OLAH(1), OXSM(4) 3627785 35 18 35 8 13 10 0 10 2 0 0.118 1.000 1.000 256 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(8), GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA5(8), GABRA6(4), GPHN(11), NSF(1), SRC(3), UBQLN1(2) 2650347 55 33 52 19 16 11 1 19 8 0 0.430 1.000 1.000 257 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), GOT1(5), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PGK1(3), PKM2(2), RPE(2), RPIA(3), TKT(3), TPI1(1) 3951379 47 29 47 10 14 8 1 19 5 0 0.0778 1.000 1.000 258 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(3), BHMT(3), CBS(2), CTH(1), DNMT1(12), DNMT3A(6), DNMT3B(3), MARS(3), MAT1A(5), MAT2B(2), MTR(6) 3922992 46 28 43 10 22 8 1 8 7 0 0.0617 1.000 1.000 259 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(6), LPO(2), MPO(3), PRDX6(2), SHMT1(1), SHMT2(2), TPO(8) 2562702 27 21 26 9 17 3 0 4 3 0 0.412 1.000 1.000 260 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 ALG2(3), BAK1(1), BAX(1), BFAR(1), BTK(6), CAD(10), CASP10(2), CASP3(1), CASP8(11), CASP8AP2(12), CD7(1), CSNK1A1(2), DFFA(2), DIABLO(1), EGFR(10), EPHB2(7), FAF1(4), FAIM2(3), IL1A(1), MAP2K4(9), MAP3K1(6), MAP3K5(5), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MET(4), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PFN2(1), PTPN13(8), RALBP1(4), RIPK1(2), ROCK1(8), SMPD1(6), TP53(76), TPX2(7), TRAF2(1), TUFM(1) 15790156 244 102 214 43 82 46 2 68 45 1 2.50e-05 1.000 1.000 261 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(7), HDC(3), TPH1(1) 1328697 15 12 15 6 6 2 1 6 0 0 0.604 1.000 1.000 262 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 34 AKT1(2), BAD(1), BCL2(1), BCL2L1(1), CBL(2), CFLAR(2), CRKL(2), GRB2(2), IL2RA(2), IL2RB(1), IRS1(5), JAK1(3), JAK3(6), MAPK1(2), MAPK3(2), NMI(1), PIK3CA(33), PIK3R1(5), PTPN6(4), RAF1(4), RPS6KB1(3), SHC1(3), SOS1(5), STAT5B(2) 7931451 94 49 76 24 26 31 4 25 8 0 0.0475 1.000 1.000 263 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(3), CBS(2), CTH(1), GGT1(3), MARS(3), MAT1A(5), MAT2B(2), PAPSS1(1), PAPSS2(2), SCLY(1), SEPHS1(1) 2730630 24 16 22 9 11 7 1 4 1 0 0.407 1.000 1.000 264 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(2), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), NTAN1(3), SIRT1(4), SIRT2(1), SIRT5(1), SIRT7(1), VNN2(1) 2650615 22 17 22 8 8 7 0 2 5 0 0.483 1.000 1.000 265 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(5), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2) 1945180 19 14 19 6 11 4 0 4 0 0 0.399 1.000 1.000 266 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(2), CYP11B1(5), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2) 1945180 19 14 19 6 11 4 0 4 0 0 0.399 1.000 1.000 267 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(2), CDC25A(2), CDC25B(5), CDC25C(3), CSK(1), GRB2(2), PRKCA(2), PTPRA(2), SRC(3) 2093510 22 19 22 8 5 6 1 10 0 0 0.599 1.000 1.000 268 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 25 GH1(1), GHR(6), GRB2(2), INSR(5), IRS1(5), JAK2(6), MAP2K1(3), MAPK1(2), MAPK3(2), PIK3CA(33), PIK3R1(5), PLCG1(4), PRKCA(2), PTPN6(4), RAF1(4), RPS6KA1(1), SHC1(3), SLC2A4(3), SOS1(5), SRF(3), STAT5B(2) 7318393 101 52 84 26 29 30 5 30 6 1 0.0599 1.000 1.000 269 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(2), CDC25B(5), CDK7(1), CDKN1A(1), CHEK1(1), NEK1(7), WEE1(3) 1491350 20 12 19 7 7 4 0 8 1 0 0.725 1.000 1.000 270 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 ACTA1(3), CRKL(2), DOCK1(5), GAB1(6), GRB2(2), HGF(5), ITGA1(3), ITGB1(6), MAP2K1(3), MAP4K1(2), MAPK1(2), MAPK3(2), MAPK8(2), MET(4), PAK1(4), PIK3CA(33), PIK3R1(5), PTEN(6), PTK2(5), PTK2B(1), PTPN11(2), RAF1(4), RAP1A(1), RAP1B(2), RASA1(5), SOS1(5), SRC(3), STAT3(2) 9638276 125 57 108 25 27 48 4 33 12 1 0.00163 1.000 1.000 271 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(1), BAD(1), BRAF(21), CREB1(1), CREB3(2), CREB5(2), DUSP4(1), DUSP6(4), DUSP9(1), GRB2(2), MAP2K1(3), MAP3K8(2), MAPK1(2), MAPK3(2), MKNK1(1), MKNK2(2), MOS(2), NFKB1(3), RAP1A(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), SHC1(3), SOS1(5), SOS2(9), TRAF3(4) 6740499 87 44 68 21 20 16 3 37 11 0 0.145 1.000 1.000 272 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), GOT1(5), GOT2(1), GPT2(2), MDH1(1), MDH2(1), ME1(7), ME3(4), PGK1(3), PGK2(6), PKM2(2), RPE(2), RPIA(3), TKT(3), TKTL1(4), TKTL2(5), TPI1(1) 4423644 59 32 59 14 19 11 0 23 6 0 0.0860 1.000 1.000 273 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(2), ITGA4(3), ITGAL(5), ITGAM(5), ITGB1(6), ITGB2(4), PECAM1(1), SELE(2), SELP(4) 3375617 35 19 34 10 12 10 0 10 3 0 0.229 1.000 1.000 274 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), DPYD(8), DPYS(6), ENPP1(4), ENPP3(3), PANK1(2), PANK3(2), PANK4(1), PPCS(1), UPB1(3) 3096359 31 17 31 7 6 12 1 9 3 0 0.132 1.000 1.000 275 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(3), ABAT(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH9A1(1), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), L2HGDH(3), OXCT1(3), PDHA1(4), PDHA2(6), PDHB(2), SDHB(2), SDS(2) 5850651 82 36 82 14 31 20 0 25 6 0 0.000971 1.000 1.000 276 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(5), ABP1(1), ACADM(3), ACADSB(5), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(8), DPYS(6), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), MLYCD(1), SDS(2), SMS(2), UPB1(3) 6492162 92 34 92 16 34 25 1 25 7 0 0.000576 1.000 1.000 277 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 IMPA1(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPPL1(3), ITPKB(4), MIOX(1), OCRL(5), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3CA(33), PIK3CB(2), PIK3CG(12), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCG1(4), PLCG2(9) 9751561 127 56 111 24 46 41 3 29 8 0 0.000581 1.000 1.000 278 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CCR3(3), CFL1(1), GNAQ(3), GNAS(6), GNB1(1), LIMK1(4), MAP2K1(3), MAPK1(2), MAPK3(2), MYL2(1), NOX1(1), PIK3C2G(7), PLCB1(8), PPP1R12B(5), PRKCA(2), PTK2(5), RAF1(4), ROCK2(2) 5480277 60 39 58 11 24 8 2 17 9 0 0.0617 1.000 1.000 279 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(5), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), IDS(2), IDUA(1), LCT(15), NAGLU(3) 3239477 37 22 37 10 16 6 2 9 4 0 0.136 1.000 1.000 280 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG5(3), ATG7(1), BECN1(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNG(1), PIK3C3(5), PIK3R4(12), PRKAA1(2), PRKAA2(6), ULK2(4), ULK3(3) 4640726 59 28 59 14 11 17 2 26 3 0 0.179 1.000 1.000 281 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C8B(9), C9(4), MASP1(9) 4614887 62 35 62 21 20 12 1 20 8 1 0.433 1.000 1.000 282 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(4), CREBBP(21), EP300(13), HDAC3(2), IKBKB(2), NFKB1(3), RELA(2), RIPK1(2), TNFRSF1A(1), TRADD(1), TRAF6(4) 5084139 55 32 55 17 20 19 2 7 7 0 0.222 1.000 1.000 283 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(4), CREM(4), FHL5(1), FSHB(1), FSHR(6), GNAS(6), XPO1(1) 2110062 23 20 23 8 9 5 2 5 2 0 0.577 1.000 1.000 284 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(2), IL4R(1), JAK1(3), JAK2(6), TYK2(1) 2291437 15 13 14 6 7 0 2 4 1 1 0.702 1.000 1.000 285 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(2), IL4R(1), JAK1(3), JAK2(6), TYK2(1) 2291437 15 13 14 6 7 0 2 4 1 1 0.702 1.000 1.000 286 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8) 3748230 36 19 34 9 15 6 0 12 3 0 0.202 1.000 1.000 287 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(4), MAP3K14(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), TNFRSF13B(4), TNFRSF17(2), TNFSF13(2), TRAF2(1), TRAF3(4), TRAF5(4), TRAF6(4) 3181835 37 25 36 11 17 6 0 8 6 0 0.457 1.000 1.000 288 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(9), CAMK1(1), CAMK1G(3), HDAC5(1), IGF1(2), IGF1R(7), INSR(5), MAP2K6(2), MAPK14(3), MAPK7(3), MEF2A(3), MEF2C(7), MEF2D(1), NFATC1(1), NFATC2(3), PIK3CA(33), PIK3R1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), SYT1(1) 7537190 100 51 85 28 36 31 3 20 10 0 0.0332 1.000 1.000 289 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(2), CCNH(2), CDC25A(2), CDC25B(5), CDC25C(3), CDK7(1), MNAT1(1), XPO1(1) 1996461 17 12 17 7 5 5 0 6 1 0 0.712 1.000 1.000 290 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(3), JAK2(6), JAK3(6), MAPK1(2), MAPK3(2), STAT3(2), TYK2(1) 2623606 22 15 21 9 9 4 1 5 2 1 0.679 1.000 1.000 291 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(3), ATF1(1), BRAF(21), CREB1(1), CREB3(2), CREB5(2), CREBBP(21), CRKL(2), DAG1(4), EGR1(2), EGR2(6), EGR3(2), FRS2(2), GNAQ(3), MAP1B(18), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), NTRK1(6), PIK3C2G(7), PIK3CA(33), PIK3CD(2), PIK3R1(5), PTPN11(2), RPS6KA3(3), SHC1(3), SRC(3), TERF2IP(1) 11264684 182 78 146 42 38 57 5 58 23 1 0.00355 1.000 1.000 292 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), MAP2K1(3), MAPK1(2), MAPK3(2), NFKB1(3), PLCB1(8), PRKCA(2), RAF1(4), RELA(2) 3457398 28 20 27 9 11 6 1 7 3 0 0.363 1.000 1.000 293 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(6), ABCB11(8), ABCB4(8), ABCC1(8), ABCC3(5) 3043689 35 21 35 10 5 14 0 10 6 0 0.291 1.000 1.000 294 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(3), CD28(1), CD3D(1), CD3G(2), CD4(2), ICAM1(2), ITGAL(5), ITGB2(4), PTPRC(9) 2516572 29 18 29 11 6 12 0 6 5 0 0.482 1.000 1.000 295 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(6), LPO(2), MPO(3), MTHFR(6), PRDX6(2), SHMT1(1), SHMT2(2), TPO(8) 2525058 33 23 32 10 18 5 0 7 3 0 0.351 1.000 1.000 296 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(5), ALDH4A1(2), ALDH5A1(4), CAD(10), CPS1(8), EPRS(9), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(3), GLS2(2), GLUD1(2), GLUL(3), GMPS(5), GOT1(5), GOT2(1), GPT2(2), GSS(4), NADSYN1(2), PPAT(3), QARS(7) 7400184 93 36 93 17 31 26 2 27 7 0 0.00360 1.000 1.000 297 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(2), RPE(2), UCHL1(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2) 3760199 30 18 30 10 13 8 0 4 5 0 0.473 1.000 1.000 298 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), ACTR3(2), AKT1(2), ANGPTL2(8), DAG1(4), DGKA(1), ETFA(2), ITGA9(4), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), MAP2K1(3), MAPK1(2), MAPK3(2), NR1I3(2), PAK1(4), PDE3A(5), PDE3B(2), PIK3C2G(7), PIK3CA(33), PIK3CD(2), PIK3R1(5), PLDN(1), RIPK3(4), RPS4X(1), VASP(3) 10335358 138 61 123 35 43 40 7 30 18 0 0.0205 1.000 1.000 299 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(5), ADC(1), ALDH4A1(2), ALDH5A1(4), CAD(10), CPS1(8), EPRS(9), GAD1(7), GAD2(4), GCLC(4), GCLM(1), GFPT1(3), GFPT2(3), GLS2(2), GLUD1(2), GLUD2(4), GLUL(3), GMPS(5), GOT1(5), GOT2(1), GPT2(2), GSR(1), GSS(4), NADSYN1(2), NAGK(2), PPAT(3), QARS(7) 8778770 104 44 104 24 39 28 2 28 7 0 0.0146 1.000 1.000 300 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(5), GALNT2(3), GALNT3(4), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GCNT1(3), ST3GAL1(1), ST3GAL2(1), ST3GAL4(2), WBSCR17(17) 3170950 45 30 44 14 20 10 1 5 9 0 0.226 1.000 1.000 301 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CCR5(1), CXCL12(1), CXCR4(3), GNAQ(3), MAPK14(3), MAPK8(2), PLCG1(4), PRKCA(2), PTK2B(1), SYT1(1) 2980199 21 17 22 9 6 6 0 5 4 0 0.687 1.000 1.000 302 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CSNK2A1(4), GRB2(2), IL6(1), IL6R(2), IL6ST(2), JAK1(3), JAK2(6), JAK3(6), MAP2K1(3), MAPK3(2), PTPN11(2), RAF1(4), SHC1(3), SOS1(5), SRF(3), STAT3(2) 5350675 50 28 47 13 16 10 4 14 5 1 0.180 1.000 1.000 303 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOSL2(1), IFNAR1(3), IFNAR2(1), IFNB1(1), MAPK8(2), NFKB1(3), RELA(2), TNFRSF11A(2), TNFSF11(1), TRAF6(4) 2461155 20 14 20 7 7 7 0 1 5 0 0.436 1.000 1.000 304 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(3), UBE2A(2), UBE2B(2), UBE2C(2), UBE2D1(1), UBE2E1(3), UBE2G1(2), UBE2I(1), UBE2J2(1), UBE2L3(2), UBE3A(6) 2328839 25 14 25 10 7 2 2 9 5 0 0.725 1.000 1.000 305 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(5), ABP1(1), ACADM(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), CNDP1(3), DPYD(8), DPYS(6), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADHA(2), MLYCD(1), SMS(2), UPB1(3) 6029322 77 31 77 17 28 21 1 21 6 0 0.0151 1.000 1.000 306 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(21), EP300(13), LPL(6), NCOA1(6), NCOA2(4), PPARG(1), RXRA(1) 3960836 52 26 52 18 13 20 3 9 7 0 0.376 1.000 1.000 307 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(5), AKT1(2), AKT2(5), ARAF(3), BAD(1), BRAF(21), BTC(2), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CBL(2), CBLB(6), CDKN1A(1), CDKN1B(1), CRKL(2), EGF(3), EGFR(10), ERBB2(6), ERBB3(11), ERBB4(16), EREG(1), GAB1(6), GRB2(2), GSK3B(7), HBEGF(1), KRAS(58), MAP2K1(3), MAP2K4(9), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), NRAS(15), NRG1(9), NRG2(4), NRG3(3), NRG4(1), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PRKCA(2), PRKCG(8), PTK2(5), RAF1(4), RPS6KB1(3), RPS6KB2(1), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), SRC(3), STAT5B(2) 23068575 374 121 276 78 87 114 11 130 32 0 3.20e-06 1.000 1.000 308 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(5), BRAF(21), EIF4B(1), HIF1A(1), IGF1(2), MAPK1(2), MAPK3(2), PDPK1(1), PGF(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PRKAA1(2), PRKAA2(6), RICTOR(10), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5), RPS6KB1(3), RPS6KB2(1), TSC1(3), TSC2(1), ULK2(4), ULK3(3), VEGFA(2), VEGFB(2), VEGFC(3) 11757909 151 59 117 29 39 40 3 53 16 0 0.00201 1.000 1.000 309 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(1), CYP11A1(2), CYP11B2(5), CYP17A1(2), HSD11B1(1), HSD3B1(2) 1492186 13 9 13 6 6 3 0 4 0 0 0.739 1.000 1.000 310 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(5), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), HGSNAT(6), HPSE(2), HPSE2(9), IDS(2), IDUA(1), LCT(15), NAGLU(3), SPAM1(1) 4545223 55 26 54 15 20 9 2 17 7 0 0.147 1.000 1.000 311 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(1), F13A1(8), F2(2), FGA(11), FGB(1), FGG(4), PLAT(4), PLAU(2), PLG(7), SERPINB2(4), SERPINE1(1) 3021691 45 28 45 13 12 16 1 11 5 0 0.224 1.000 1.000 312 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4) 3866608 44 23 44 15 14 9 0 13 7 1 0.489 1.000 1.000 313 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(27), BMPR1B(9), CCND2(1), CDK4(2), CDKN1B(1), DAZL(1), DMC1(3), EGR1(2), ESR2(2), FSHR(6), GJA4(2), INHA(2), LHCGR(4), MLH1(5), MSH5(4), NCOR1(7), NRIP1(5), PGR(4), PRLR(2), PTGER2(1), SMPD1(6), VDR(1), ZP2(6) 7874702 103 46 103 25 29 23 1 31 18 1 0.0806 1.000 1.000 314 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(3), ATIC(4), GART(3), MTHFD1(6), MTHFD1L(6), MTHFR(6), MTHFS(1), MTR(6), SHMT1(1), SHMT2(2), TYMS(2) 4025255 40 23 40 10 17 9 0 11 3 0 0.146 1.000 1.000 315 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(2), SEC61A2(1), SRP19(1), SRP54(1), SRP68(1), SRP72(3) 1688761 9 8 9 4 4 2 0 3 0 0 0.774 1.000 1.000 316 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(2), RPE(2), UGDH(3), UGP2(5), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), XYLB(2) 5599014 63 27 62 15 16 17 1 18 11 0 0.169 1.000 1.000 317 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(3), ALG10B(4), ALG11(1), ALG12(2), ALG13(1), ALG2(3), ALG3(1), ALG5(2), ALG6(3), ALG8(5), ALG9(1), B4GALT1(5), B4GALT2(3), B4GALT3(6), DAD1(2), DDOST(2), DPAGT1(1), DPM1(1), FUT8(1), GANAB(4), MAN1A1(4), MAN1A2(2), MAN1B1(2), MAN1C1(4), MAN2A1(8), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), ST6GAL1(1), STT3B(4) 9335910 87 44 86 17 30 17 2 33 5 0 0.0129 1.000 1.000 318 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(2), F3(1), F5(14), F7(2), FGA(11), FGB(1), FGG(4), PROC(1), PROS1(3), SERPINC1(3) 3678123 43 24 43 10 9 11 1 18 4 0 0.164 1.000 1.000 319 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(10), C5(9), C6(10), C7(2), ICAM1(2), IL1A(1), IL6(1), ITGA4(3), ITGAL(5), ITGB1(6), ITGB2(4), SELP(4), SELPLG(1), VCAM1(7) 5436298 65 33 64 20 23 17 0 18 6 1 0.178 1.000 1.000 320 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 3428459 29 19 28 8 11 11 1 3 3 0 0.218 1.000 1.000 321 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 3428459 29 19 28 8 11 11 1 3 3 0 0.218 1.000 1.000 322 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 3428459 29 19 28 8 11 11 1 3 3 0 0.218 1.000 1.000 323 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(4), IFNG(1), IKBKB(2), IL2(3), IL4(3), MAP3K1(6), MAP3K5(5), MAP4K5(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), TNFRSF9(2), TRAF2(1) 4317884 39 20 39 11 17 8 1 11 2 0 0.271 1.000 1.000 324 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(3), ATIC(4), FTCD(2), GART(3), MTFMT(1), MTHFD1(6), MTHFD1L(6), MTHFR(6), MTHFS(1), MTR(6), SHMT1(1), SHMT2(2), TYMS(2) 4217828 43 25 43 11 18 9 0 11 5 0 0.170 1.000 1.000 325 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(2), ACP2(2), ACP5(1), ACPP(3), ENPP1(4), ENPP3(3), FLAD1(1), TYR(2) 2172537 18 12 17 7 7 5 1 4 1 0 0.591 1.000 1.000 326 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(2), B3GNT2(1), B3GNT7(4), B4GALT1(5), B4GALT2(3), B4GALT3(6), CHST1(6), CHST2(1), CHST4(5), FUT8(1), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2) 2739317 42 27 42 12 25 7 0 7 3 0 0.196 1.000 1.000 327 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 108 ABL1(4), ANAPC1(3), ANAPC10(2), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(4), ATM(27), ATR(13), BUB1(4), BUB1B(3), BUB3(2), CCNA1(4), CCNA2(3), CCNB1(2), CCNB2(2), CCNB3(4), CCND2(1), CCND3(1), CCNE1(3), CCNE2(1), CCNH(2), CDC14A(1), CDC14B(3), CDC16(3), CDC20(3), CDC23(6), CDC25A(2), CDC25B(5), CDC25C(3), CDC27(9), CDC7(2), CDK2(2), CDK4(2), CDK6(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(1), CDKN2C(1), CHEK1(1), CHEK2(1), CREBBP(21), CUL1(7), DBF4(2), E2F2(1), E2F3(1), EP300(13), ESPL1(8), GSK3B(7), HDAC1(2), HDAC2(2), MAD1L1(1), MAD2L1(1), MAD2L2(1), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), MDM2(4), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), PKMYT1(1), PLK1(6), PRKDC(13), PTTG1(1), RB1(4), RBL1(3), RBL2(8), SKP1(1), SKP2(1), SMAD2(11), SMAD3(6), SMAD4(21), SMC1A(10), SMC1B(4), TFDP1(4), TGFB1(1), TGFB2(5), TP53(76), WEE1(3), YWHAB(2), YWHAE(3), YWHAQ(1) 30097095 413 126 377 73 127 89 8 105 81 3 6.08e-08 1.000 1.000 328 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CD3D(1), CD3G(2), FYN(4), GRB2(2), LCK(2), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), PIK3CA(33), PIK3R1(5), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), PTPN7(1), RAF1(4), RASA1(5), RELA(2), SHC1(3), SOS1(5), SYT1(1), VAV1(11), ZAP70(4) 10545774 136 63 118 30 43 38 8 27 20 0 0.00256 1.000 1.000 329 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 ACTA1(3), AGT(4), AKT1(2), CAMK1(1), CAMK1G(3), CAMK4(2), CREBBP(21), CSNK1A1(2), EDN1(1), ELSPBP1(1), F2(2), GATA4(1), GSK3B(7), HAND1(1), HAND2(1), IGF1(2), MAP2K1(3), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), MEF2C(7), MYH2(9), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NKX2-5(1), NPPA(1), PIK3CA(33), PIK3R1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RAF1(4), RPS6KB1(3), SYT1(1) 10959009 157 60 141 33 48 53 5 32 19 0 0.000221 1.000 1.000 330 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), DAG1(4), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), NFAT5(5), PDE6A(6), PDE6B(5), PDE6C(8), PDE6D(1), SLC6A13(5), TF(7) 7620555 86 38 86 26 35 13 7 23 8 0 0.168 1.000 1.000 331 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(1), GNAS(6), GNB1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2) 2073571 17 16 17 6 7 1 2 6 1 0 0.597 1.000 1.000 332 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(5), BAD(1), BCR(6), BTK(6), CD19(3), CSK(1), DAG1(4), EPHB2(7), GRB2(2), ITPKB(4), LYN(4), MAP2K1(3), MAPK1(2), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PIK3CA(33), PIK3CD(2), PIK3R1(5), PLCG2(9), PPP1R13B(5), RAF1(4), SERPINA4(2), SHC1(3), SOS1(5), SOS2(9), VAV1(11) 11634419 151 66 132 34 52 43 8 36 12 0 0.00195 1.000 1.000 333 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(3), FUCA1(1), GLB1(3), HEXB(1), LCT(15), MAN2C1(6), MANBA(6), NEU2(1), NEU3(1) 3649275 37 22 37 12 15 12 1 8 1 0 0.321 1.000 1.000 334 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B4GALT5(2), C1GALT1C1(2), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(5), GALNT14(9), GALNT2(3), GALNT3(4), GALNT5(6), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GALNTL1(3), GALNTL2(6), GALNTL4(1), GALNTL5(5), GCNT1(3), GCNT3(2), GCNT4(5), OGT(4), ST3GAL1(1), ST3GAL2(1), ST6GALNAC1(2), WBSCR17(17) 7249211 100 47 99 24 42 22 2 19 15 0 0.0407 1.000 1.000 335 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(9), CAPN2(5), CAPNS1(1), CAPNS2(1), EP300(13), HDAC1(2), HDAC2(2), MEF2D(1), NFATC1(1), NFATC2(3), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), SYT1(1) 5395101 49 27 49 12 20 12 1 7 9 0 0.0686 1.000 1.000 336 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(3), BHMT(3), CBS(2), CTH(1), DNMT1(12), DNMT3A(6), DNMT3B(3), MARS(3), MAT1A(5), MAT2B(2), MTFMT(1), MTR(6), TAT(3) 4639101 50 30 47 13 23 10 1 8 8 0 0.119 1.000 1.000 337 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), ARSD(3), ARSE(2), CARM1(2), CYP11B1(5), CYP11B2(5), CYP19A1(5), HSD11B1(1), HSD17B12(2), HSD17B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SRD5A1(1), SRD5A2(1), STS(6), SULT1E1(1), SULT2A1(1), SULT2B1(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), WBSCR22(1) 10575119 110 44 109 24 35 26 3 30 16 0 0.00827 1.000 1.000 338 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(4), GNAS(6), PLCE1(7), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2) 3063357 24 20 24 9 10 4 2 5 3 0 0.512 1.000 1.000 339 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 CYP51A1(3), DHCR7(2), FDFT1(2), HMGCR(2), HMGCS1(1), IDI1(1), LSS(1), MVK(1), NSDHL(2), PMVK(1), SC5DL(1), SQLE(1) 2931328 18 13 18 7 8 5 0 3 2 0 0.575 1.000 1.000 340 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), BCAT2(1), DPYD(8), DPYS(6), ENPP1(4), ENPP3(3), ILVBL(2), PANK1(2), PANK3(2), PANK4(1), PPCS(1), UPB1(3), VNN1(5) 3855756 39 21 39 11 10 14 2 10 3 0 0.208 1.000 1.000 341 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(20), MAP2(21), PPP2CA(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2), PRKCE(4) 4022801 52 31 52 13 16 11 1 14 10 0 0.208 1.000 1.000 342 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(5), CARM1(2), CREBBP(21), EP300(13), ERCC3(6), ESR1(12), GRIP1(7), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC1(2), HDAC2(2), HDAC3(2), HDAC4(5), HDAC5(1), HDAC6(4), MEF2C(7), NCOR2(2), NR0B1(2), NRIP1(5), PELP1(2), POLR2A(6), TBP(1) 10270007 117 46 117 24 45 34 2 21 15 0 0.000825 1.000 1.000 343 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), B4GALNT1(3), GLB1(3), HEXB(1), LCT(15), SLC33A1(1), ST3GAL1(1), ST3GAL2(1), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(4), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(4) 3639543 44 25 44 15 20 8 2 9 5 0 0.338 1.000 1.000 344 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 14 ABCA1(17), APOE(1), CETP(6), CYP7A1(4), HMGCR(2), LCAT(1), LDLR(4), LIPC(3), LPL(6), LRP1(14), SOAT1(1) 5616048 59 31 59 18 22 14 2 16 5 0 0.209 1.000 1.000 345 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(6), AGT(4), AGTR2(4), EDN1(1), EDNRA(4), EDNRB(7), EGF(3), EGFR(10), NFKB1(3), PLCG1(4), PRKCA(2), RELA(2) 4624834 50 31 50 16 22 9 0 14 5 0 0.302 1.000 1.000 346 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(8), ABCC2(11), ABCG2(5), BCHE(7), CES1(4), CES2(1), CYP3A4(1), CYP3A5(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5) 5111957 55 23 55 18 21 11 0 16 7 0 0.351 1.000 1.000 347 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(1), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), AOC2(4), AOC3(4), ASPA(3), CNDP1(3), DDC(1), HAL(3), HARS(2), HDC(3), HNMT(4), MAOA(2), PRPS2(2) 5386561 63 31 63 15 26 19 0 17 1 0 0.0310 1.000 1.000 348 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 CSNK2A1(4), GRB2(2), JAK2(6), MAP2K1(3), MAPK3(2), MAPK8(2), PLCG1(4), PTPN6(4), RAF1(4), SHC1(3), SOS1(5), STAT5B(2) 4791619 41 22 39 11 16 8 4 9 3 1 0.221 1.000 1.000 349 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(1), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(6), GOT1(5), GOT2(1), HPD(3), LPO(2), MAOA(2), MPO(3), PRDX6(2), TAT(3), TPO(8) 4812986 54 33 53 16 29 12 0 10 3 0 0.129 1.000 1.000 350 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(10), EXTL1(3), EXTL2(3), EXTL3(7), GLCE(3), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), NDST1(3), NDST2(5), NDST3(7), NDST4(4) 4563247 60 36 60 16 26 15 2 13 4 0 0.0999 1.000 1.000 351 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(3), CYP51A1(3), DHCR24(2), DHCR7(2), EBP(2), FDFT1(2), GGCX(2), HMGCR(2), IDI1(1), IDI2(1), LSS(1), MVK(1), NQO1(1), NSDHL(2), PMVK(1), SC5DL(1), SQLE(1) 4283678 28 19 28 9 10 7 1 6 4 0 0.414 1.000 1.000 352 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 CDK5R1(1), DAB1(4), FYN(4), LRP8(1), RELN(24), VLDLR(3) 3147821 37 25 36 14 10 8 3 11 5 0 0.513 1.000 1.000 353 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(1), AOC2(4), AOC3(4), CES1(4), DDHD1(1), ESCO1(7), ESCO2(3), LIPA(1), MYST3(13), MYST4(5), PLA1A(3), PNPLA3(4), PPME1(2), PRDX6(2), SH3GLB1(3) 5596368 59 27 59 18 26 17 1 10 5 0 0.229 1.000 1.000 354 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(5), ACACA(14), ACADM(3), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), LDHA(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(3), PCCA(3), PCCB(3), SDS(2), SUCLA2(3), SUCLG1(1) 7487866 88 35 88 16 33 22 0 23 10 0 0.00532 1.000 1.000 355 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(7), ADSS(1), HPRT1(2), IMPDH1(1), POLB(1), POLD1(5), POLG(4), PRPS2(2), RRM1(1) 2776445 24 19 24 9 11 5 0 7 1 0 0.546 1.000 1.000 356 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 68 ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C2(3), AKR1C4(2), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), CYP1A1(6), CYP1A2(2), CYP1B1(2), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2S1(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), DHDH(1), EPHX1(5), GSTA1(1), GSTA3(3), GSTA5(1), GSTM2(2), GSTM3(2), GSTM4(2), GSTM5(1), GSTZ1(2), MGST1(2), MGST3(1), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4) 12183644 143 52 142 33 39 30 4 52 17 1 0.0221 1.000 1.000 357 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(2), IL4(3), IL4R(1), IRS1(5), JAK1(3), JAK3(6), RPS6KB1(3), SHC1(3), STAT6(2) 3261578 30 21 28 10 10 7 2 6 5 0 0.472 1.000 1.000 358 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 11 DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(7), ESCO2(3), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3) 3588155 40 21 40 13 19 10 1 6 4 0 0.363 1.000 1.000 359 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(12), COL4A2(3), COL4A3(3), COL4A4(8), COL4A5(17), COL4A6(15), F10(1), F11(4), F12(2), F2(2), F5(14), F8(15), F9(6), FGA(11), FGB(1), FGG(4), KLKB1(4), PROC(1), PROS1(3), SERPINC1(3), SERPING1(3) 9906978 132 48 129 31 26 35 3 45 23 0 0.0157 1.000 1.000 360 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA2(2), ANXA3(1), ANXA4(4), ANXA5(1), ANXA6(2), CYP11A1(2), EDN1(1), EDNRA(4), EDNRB(7), HSD11B1(1), PLA2G4A(5), PRL(2), PTGER2(1), PTGFR(6), PTGIR(1), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5) 4566096 55 26 55 14 22 7 0 21 5 0 0.164 1.000 1.000 361 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(2), ACAD9(3), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AKR1C4(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), BAAT(2), CEL(1), CYP27A1(3), CYP7A1(4), HADHB(1), HSD3B7(2), LIPA(1), RDH12(2), RDH13(1), SLC27A5(3), SOAT1(1), SOAT2(1), SRD5A1(1), SRD5A2(1) 7024563 71 36 71 20 20 21 2 23 5 0 0.127 1.000 1.000 362 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(4), GNA12(2), GNA13(2), GNAQ(3), GNB1(1), MYL2(1), MYLK(11), PLCB1(8), PPP1R12B(5), PRKCA(2), ROCK1(8) 4624957 53 30 51 14 13 10 3 15 12 0 0.329 1.000 1.000 363 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(2), ACADM(3), ACADSB(5), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH9A1(1), AOX1(5), BCAT1(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(2), HADHB(1), MCCC1(7), MCCC2(2), MCEE(1), MUT(3), OXCT1(3), PCCA(3), PCCB(3), SDS(2) 8132470 85 37 85 18 33 19 0 24 9 0 0.0123 1.000 1.000 364 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDFT1(2), HMGCR(2), IDI1(1), LSS(1), MVK(1), NQO1(1), PMVK(1), SC5DL(1), SQLE(1) 2465998 13 12 13 6 7 4 0 1 1 0 0.612 1.000 1.000 365 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 BCR(6), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8IP3(1), PAPPA(13), RPS6KA1(1), RPS6KA3(3), SHC1(3), SOS1(5), VAV1(11), VAV2(2), VAV3(10) 7136320 74 38 72 20 30 13 5 20 6 0 0.0889 1.000 1.000 366 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(1), SHMT1(1) 3625575 30 19 29 9 11 11 1 4 3 0 0.288 1.000 1.000 367 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(5), BCR(6), BTK(6), CD19(3), CDKN2A(1), DAPP1(1), FLOT1(3), GAB1(6), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), PHF11(2), PIK3CA(33), PITX2(2), PLCG2(9), PPP1R13B(5), PREX1(14), PTEN(6), PTPRC(9), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SAG(1), TEC(1), VAV1(11) 11806108 179 63 161 47 63 52 5 41 17 1 0.00925 1.000 1.000 368 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3D(1), CD3G(2), CD4(2), CREBBP(21), CSK(1), GNAS(6), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTPRC(9), ZAP70(4) 5029023 65 34 65 20 21 20 5 8 9 2 0.177 1.000 1.000 369 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(4), CD3D(1), CD3G(2), CD4(2), CREBBP(21), CSK(1), GNAS(6), GNB1(1), HLA-DRA(4), HLA-DRB1(1), LCK(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTPRC(9), ZAP70(4) 5029023 65 34 65 20 21 20 5 8 9 2 0.177 1.000 1.000 370 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(1), CREB1(1), CREB3(2), CREB5(2), DUSP1(2), DUSP10(4), IL1R1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K10(2), MAP3K4(15), MAP3K5(5), MAP3K7(2), MAPK1(2), MAPK12(2), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MKNK1(1), MKNK2(2), MYEF2(7), NFKB1(3), NR2C2(4), SRF(3), TRAF6(4) 7618293 89 40 87 22 27 22 3 24 13 0 0.0731 1.000 1.000 371 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(2), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), DDOST(2), DPAGT1(1), DPM1(1), FUT8(1), MAN1A1(4), MAN1B1(2), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), ST6GAL1(1) 4407199 40 26 40 10 18 8 2 11 1 0 0.129 1.000 1.000 372 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(4), ABAT(5), ADSL(7), ADSS(1), AGXT2(5), ASNS(1), ASPA(3), CAD(10), CRAT(3), DARS(3), DDO(2), GAD1(7), GAD2(4), GOT1(5), GOT2(1), GPT2(2), NARS(2), PC(3) 5826986 68 38 68 18 31 16 0 17 4 0 0.0801 1.000 1.000 373 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 APAF1(7), ARHGDIB(3), BIRC2(2), BIRC3(2), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), DFFA(2), DFFB(2), GZMB(1), LMNB1(2), LMNB2(1) 4344430 47 28 46 12 9 11 2 18 7 0 0.342 1.000 1.000 374 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), G6PD(2), GPI(1), H6PD(3), PFKM(1), PFKP(2), PGD(1), PGM1(2), PGM3(4), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3) 4473705 39 26 39 14 15 8 0 15 1 0 0.453 1.000 1.000 375 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(3), CARM1(2), CBS(2), CTH(1), GGT1(3), LCMT1(1), LCMT2(2), MARS(3), MAT1A(5), MAT2B(2), METTL2B(1), METTL6(5), PAPSS1(1), PAPSS2(2), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SCLY(1), SEPHS1(1), SEPHS2(3), WBSCR22(1) 5392368 49 28 47 18 18 14 1 13 3 0 0.401 1.000 1.000 376 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(3), FUCA1(1), GLB1(3), HEXB(1), LCT(15), MAN2B1(4), MAN2B2(1), MAN2C1(6), MANBA(6), NEU2(1), NEU3(1) 4482628 42 23 42 15 15 14 1 11 1 0 0.427 1.000 1.000 377 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(2), GNAI1(3), GNB1(1), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), PLA2G4A(5), PLCB1(8), PRKCA(2), PTGS1(4), PTK2(5), RAF1(4), SRC(3), TBXAS1(5) 5545245 58 32 57 17 23 13 2 17 3 0 0.226 1.000 1.000 378 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(4), ACO1(3), ACO2(2), CLYBL(5), FH(1), IDH1(3), IDH2(7), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), OGDHL(8), PC(3), PCK2(3), SDHA(5), SDHB(2), SDHD(1), SUCLA2(3), SUCLG1(1) 6599349 60 36 60 19 27 14 0 14 5 0 0.197 1.000 1.000 379 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(4), AARS2(6), ABAT(5), ADSL(7), ADSS(1), AGXT2(5), ASNS(1), ASPA(3), ASS1(1), CAD(10), CRAT(3), DARS(3), DARS2(2), DDO(2), DLAT(2), GAD1(7), GAD2(4), GOT1(5), GOT2(1), GPT2(2), NARS(2), NARS2(3), PC(3), PDHA1(4), PDHA2(6), PDHB(2) 8480475 94 43 94 23 41 23 0 21 9 0 0.0265 1.000 1.000 380 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CDKN1A(1), GNAQ(3), MARCKS(1), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), SP1(2), SP3(2), SYT1(1) 4620567 36 26 36 12 14 4 0 10 8 0 0.450 1.000 1.000 381 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 IMPA1(2), IMPA2(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPP5B(1), INPPL1(3), IPMK(2), ITGB1BP3(1), ITPK1(2), ITPKB(4), MIOX(1), OCRL(5), PI4KA(11), PI4KB(2), PIK3C3(5), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(8), SYNJ2(5) 16151702 192 63 173 40 74 52 7 39 18 2 6.45e-05 1.000 1.000 382 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(3), ACO2(2), FH(1), IDH1(3), IDH2(7), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), PC(3), SDHA(5), SDHB(2), SUCLA2(3), SUCLG1(1) 4536508 35 25 35 13 17 7 0 7 4 0 0.420 1.000 1.000 383 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(4), AGTR2(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), F2(2), FYN(4), GNA11(1), GNAI1(3), GNB1(1), GRB2(2), JAK2(6), MAP2K1(3), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPT(4), MYLK(11), PLCG1(4), PRKCA(2), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), STAT1(6), STAT3(2), SYT1(1) 9409930 89 42 87 27 25 24 9 21 9 1 0.219 1.000 1.000 384 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(4), IFNA1(1), IFNB1(1), IKBKB(2), IL1A(1), IL1R1(3), IL1RN(2), IL6(1), IRAK1(1), IRAK2(8), IRAK3(1), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K7(2), MAPK14(3), MAPK8(2), MYD88(1), NFKB1(3), RELA(2), TGFB1(1), TGFB2(5), TOLLIP(1), TRAF6(4) 6490404 61 27 61 18 26 9 1 18 7 0 0.308 1.000 1.000 385 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(6), CD79A(3), GRB2(2), LYN(4), MAP2K1(3), MAP3K1(6), MAPK14(3), MAPK3(2), MAPK8(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKCA(2), RAF1(4), SHC1(3), SOS1(5), SYT1(1), VAV1(11) 8481984 81 38 79 23 34 15 4 17 11 0 0.102 1.000 1.000 386 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 21 ACAD9(3), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), DHRS1(1), DHRS2(2), DHRS3(2), ESCO1(7), ESCO2(3), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3) 5401496 63 31 63 22 22 16 3 18 4 0 0.427 1.000 1.000 387 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), DLAT(2), FH(1), IDH2(7), IDH3A(1), IDH3G(2), MDH1(1), MDH2(1), OGDH(4), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PDHX(2), PDK2(1), PDK4(2), SDHA(5), SDHB(2), SDHD(1), SUCLA2(3), SUCLG1(1) 6317060 53 29 53 17 25 11 0 8 9 0 0.251 1.000 1.000 388 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(1), GCDH(3), HADHA(2), PLOD1(3), PLOD2(4), PLOD3(3), SDS(2), SHMT1(1), SHMT2(2), TMLHE(1) 8264402 76 34 76 17 29 17 0 20 10 0 0.0178 1.000 1.000 389 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(4), CARS(5), DARS(3), EPRS(9), FARS2(4), GARS(3), HARS(2), IARS(5), KARS(3), LARS(4), LARS2(2), MARS(3), NARS(2), QARS(7), RARS(2), SARS(1), TARS(3), WARS(1), WARS2(2), YARS(2) 7253005 67 32 67 11 27 15 1 17 7 0 0.0143 1.000 1.000 390 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(2), AP2M1(4), BAD(1), BTK(6), EEA1(5), GRASP(1), GSK3A(2), GSK3B(7), LYN(4), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PLCG1(4), PRKCE(4), RPS6KB1(3), VAV2(2) 5537719 52 29 52 12 21 14 1 7 8 1 0.0497 1.000 1.000 391 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 23 ACAT1(1), ACAT2(2), ACOT11(3), ACYP1(1), DHRS1(1), DHRS2(2), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(7), ESCO2(3), GCDH(3), HADHA(2), ITGB1BP3(1), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3), YOD1(1) 5703075 58 29 58 16 25 14 1 10 8 0 0.137 1.000 1.000 392 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(14), ACAT1(1), ACAT2(2), ACYP1(1), ADH5(1), AKR1B1(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), DLAT(2), LDHA(1), LDHB(1), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PKM2(2) 8241166 89 36 89 22 32 23 1 23 10 0 0.0402 1.000 1.000 393 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(3), EGFR(10), MAP2K1(3), MAP3K1(6), MAPK14(3), NCOR2(2), RXRA(1), THRA(2), THRB(4) 3838907 34 21 34 13 17 7 2 6 2 0 0.482 1.000 1.000 394 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(13), ATP4B(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(5), ATP7B(4), COX10(2), COX4I1(2), COX6A2(1), COX6C(1), COX7A1(1), NDUFA1(1), NDUFA10(2), NDUFA4(1), NDUFB2(1), NDUFB6(1), NDUFS1(4), NDUFV1(2), PPA2(1), SDHA(5), SDHB(2), SHMT1(1), UQCRB(2), UQCRC1(2), UQCRFS1(1), UQCRH(1) 8087113 85 35 84 22 34 28 1 16 6 0 0.0286 1.000 1.000 395 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 CHIA(5), CHIT1(4), CMAS(5), CTBS(4), CYB5R1(1), CYB5R3(1), GFPT1(3), GFPT2(3), GNE(2), GNPDA2(1), HEXB(1), HK1(6), HK2(3), HK3(4), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), NAGK(2), NPL(2), PGM3(4), PHPT1(1), RENBP(1) 6461582 63 33 63 17 25 17 0 16 5 0 0.146 1.000 1.000 396 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CDK5R1(1), CSNK1D(3), DRD1(1), DRD2(3), GRM1(9), PLCB1(8), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2) 3477115 35 25 35 13 14 7 1 8 5 0 0.565 1.000 1.000 397 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 22 ACP1(2), ACP2(2), ACP5(1), ACPP(3), ALPI(2), ALPL(1), ALPP(1), CYP3A4(1), CYP3A5(3), CYP3A7(4), DHRS1(1), DHRS2(2), DHRS3(2), PON1(5), PON2(1), PON3(2) 3849529 33 19 32 13 13 5 4 6 4 1 0.534 1.000 1.000 398 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(5), ALDOC(1), DERA(1), FBP2(2), G6PD(2), GPI(1), H6PD(3), PFKL(1), PFKM(1), PFKP(2), PGD(1), PGM1(2), PGM3(4), PRPS1L1(1), PRPS2(2), RPE(2), RPIA(3), TALDO1(3), TKT(3), TKTL1(4), TKTL2(5) 5346457 50 28 50 16 20 12 0 16 2 0 0.261 1.000 1.000 399 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(3), APOA2(1), CD36(1), CITED2(1), CPT1B(5), CREBBP(21), DUSP1(2), EHHADH(2), EP300(13), FABP1(1), HSD17B4(3), LPL(6), MAPK1(2), MAPK3(2), ME1(7), NCOA1(6), NCOR1(7), NCOR2(2), NR1H3(4), NR2F1(2), NRIP1(5), PDGFA(1), PIK3CA(33), PIK3R1(5), PPARA(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(4), RELA(2), RXRA(1), SP1(2), STAT5B(2) 13928529 158 60 143 42 39 53 5 40 20 1 0.0265 1.000 1.000 400 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(5), ACACA(14), ACACB(14), ACADM(3), ACAT1(1), ACAT2(2), ACSS1(3), ACSS2(5), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH7A1(1), ALDH9A1(1), ECHS1(2), EHHADH(2), HADHA(2), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), MCEE(1), MLYCD(1), MUT(3), PCCA(3), PCCB(3), SUCLA2(3), SUCLG1(1) 8990441 98 40 98 23 37 23 0 28 10 0 0.0366 1.000 1.000 401 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(3), ACADVL(1), ACSL1(3), ACSL3(6), ACSL4(4), CPT1A(5), CPT2(1), EHHADH(2), HADHA(2), SCP2(3), SLC25A20(1) 3805487 31 19 31 11 9 8 0 10 4 0 0.542 1.000 1.000 402 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(1), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), DDC(1), EPX(6), ESCO1(7), ESCO2(3), GOT1(5), GOT2(1), HPD(3), LPO(2), MAOA(2), MPO(3), MYST3(13), MYST4(5), PNPLA3(4), PRDX6(2), SH3GLB1(3), TAT(3), TPO(8) 7576776 89 39 88 26 45 22 1 16 5 0 0.0735 1.000 1.000 403 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(5), BAD(1), BCL2(1), BCR(6), BTK(6), CD19(3), CD22(8), CR2(9), CSK(1), DAG1(4), FLOT1(3), GRB2(2), GSK3A(2), GSK3B(7), INPP5D(2), ITPR1(11), ITPR2(12), ITPR3(11), LYN(4), MAP4K1(2), MAPK1(2), MAPK3(2), NFATC1(1), NFATC2(3), PIK3CA(33), PIK3CD(2), PIK3R1(5), PLCG2(9), PPP1R13B(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PTPRC(9), RAF1(4), SHC1(3), SOS1(5), SOS2(9), VAV1(11) 15857491 213 69 195 49 73 58 8 49 25 0 0.000302 1.000 1.000 404 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSA(1), ARSB(5), ARSD(3), ARSE(2), ASAH1(3), GALC(1), GLA(4), GLB1(3), LCT(15), NEU2(1), NEU3(1), PPAP2B(1), SMPD1(6), SPTLC1(4), SPTLC2(2), UGCG(2) 5259049 54 25 54 17 19 14 2 16 3 0 0.241 1.000 1.000 405 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 25 ACOT11(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CYP2C19(4), CYP2C9(4), DHRS1(1), DHRS2(2), DHRS3(2), ECHS1(2), EHHADH(2), ESCO1(7), ESCO2(3), HADHA(2), MYST3(13), MYST4(5), PNPLA3(4), SH3GLB1(3), YOD1(1) 6841147 78 30 78 21 33 20 1 16 8 0 0.0882 1.000 1.000 406 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(3), AADAC(2), ABAT(5), ACAT1(1), ACAT2(2), ACSM1(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH5A1(4), ALDH7A1(1), ALDH9A1(1), BDH1(1), DDHD1(1), ECHS1(2), EHHADH(2), GAD1(7), GAD2(4), HADH(1), HADHA(2), HMGCS1(1), HSD17B10(1), HSD17B4(3), HSD3B7(2), ILVBL(2), L2HGDH(3), OXCT1(3), OXCT2(1), PDHA1(4), PDHA2(6), PDHB(2), PLA1A(3), PPME1(2), PRDX6(2), RDH12(2), RDH13(1) 9170236 98 39 98 27 41 25 0 23 9 0 0.0475 1.000 1.000 407 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(32), B3GALT4(1), CDR1(1), DGKI(6), IL6ST(2), MRPL19(1), PIGK(3), RPL18A(1), RPL21(1), RPL22(2), RPL24(1), RPL28(1), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL4(2), RPL6(1), RPL7(1), RPL9(3), RPLP0(2), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS20(1), RPS23(4), RPS3(1), RPS4X(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5), RPS6KB1(3), RPS6KB2(1), RPS9(2), RPSA(1), SLC36A2(1), TBC1D10C(2), TSPAN9(2), UBA52(2), UBB(1) 11377649 112 48 111 28 39 24 1 30 18 0 0.204 1.000 1.000 408 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(13), ATP4A(8), ATP4B(1), ATP5A1(2), ATP5B(4), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), ATP5O(2), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(2), COX15(1), COX17(1), COX4I1(2), COX4I2(2), COX6A2(1), COX6C(1), COX7A1(1), COX7B2(1), COX8C(1), CYC1(1), LHPP(1), NDUFA1(1), NDUFA10(2), NDUFA12(2), NDUFA13(1), NDUFA4(1), NDUFA9(2), NDUFB1(1), NDUFB2(1), NDUFB3(1), NDUFB6(1), NDUFB9(1), NDUFC2(1), NDUFS1(4), NDUFS3(2), NDUFS6(2), NDUFV1(2), PPA1(2), PPA2(1), SDHA(5), SDHB(2), SDHD(1), TCIRG1(2), UQCRB(2), UQCRC1(2), UQCRC2(2), UQCRFS1(1), UQCRH(1) 12582049 133 44 132 32 55 36 1 29 12 0 0.00606 1.000 1.000 409 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX5(4), CYP4F2(8), CYP4F3(2), EPX(6), GGT1(3), LPO(2), MPO(3), PLA2G1B(1), PLA2G4A(5), PLA2G6(2), PRDX6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5), TPO(8) 6161484 63 33 60 21 30 13 0 16 4 0 0.273 1.000 1.000 410 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 44 ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), AGPAT1(1), AGPAT3(3), AGPAT4(6), AKR1B1(2), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), CEL(1), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), GK(3), GLA(4), GLB1(3), LCT(15), LIPC(3), LIPF(1), LIPG(2), LPL(6), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PPAP2B(1) 10583078 136 43 135 36 43 31 2 49 11 0 0.0264 1.000 1.000 411 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), C9orf95(1), CD38(1), ENPP1(4), ENPP3(3), NADK(1), NADSYN1(2), NMNAT1(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(1), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), NUDT12(2), QPRT(1) 4920917 44 26 44 17 15 15 0 9 5 0 0.420 1.000 1.000 412 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTA1(3), ACTN1(3), ACTN2(7), ACTN3(2), BCR(6), CAPN1(2), CAPNS1(1), CAPNS2(1), CRKL(2), CSK(1), FYN(4), GRB2(2), ITGA1(3), ITGB1(6), MAP2K1(3), MAPK1(2), MAPK3(2), MAPK8(2), PPP1R12B(5), PTK2(5), RAF1(4), RAP1A(1), ROCK1(8), SHC1(3), SOS1(5), SRC(3), TLN1(5), VCL(1) 10299807 92 48 89 29 38 22 3 22 7 0 0.179 1.000 1.000 413 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CRKL(2), GNAQ(3), GRB2(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), PAK1(4), PLCG1(4), PRKCA(2), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), SRC(3), SYT1(1) 6372035 63 35 60 20 17 16 5 17 8 0 0.352 1.000 1.000 414 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(5), ALAS2(5), BLVRA(2), BLVRB(1), COX10(2), COX15(1), CP(3), EPRS(9), FECH(2), FTMT(3), GUSB(2), HCCS(1), HMBS(2), HMOX1(2), HMOX2(1), MMAB(1), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), UROS(1) 8977664 93 33 91 21 25 26 1 31 10 0 0.0638 1.000 1.000 415 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CAMK1(1), CAMK1G(3), FPR1(2), GNA15(3), GNB1(1), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAP3K1(6), MAPK1(2), MAPK14(3), MAPK3(2), NCF1(1), NCF2(1), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), PAK1(4), PIK3C2G(7), PLCB1(8), PPP3CA(1), PPP3CB(4), PPP3CC(3), RAF1(4), RELA(2), SYT1(1) 8423889 81 37 80 27 31 16 3 16 15 0 0.283 1.000 1.000 416 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(4), AGTR1(3), EGFR(10), GNAQ(3), GRB2(2), MAP2K1(3), MAP2K4(9), MAP3K1(6), MAPK1(2), MAPK3(2), MAPK8(2), MEF2A(3), MEF2C(7), MEF2D(1), PAK1(4), PRKCA(2), PTK2(5), PTK2B(1), RAF1(4), SHC1(3), SOS1(5), SRC(3), SYT1(1) 7443225 85 39 82 26 27 23 4 21 10 0 0.219 1.000 1.000 417 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(3), ARSB(5), FUCA1(1), GALNS(4), GLB1(3), GNS(1), GUSB(2), HEXB(1), HGSNAT(6), HPSE(2), HPSE2(9), IDS(2), IDUA(1), LCT(15), MAN2B1(4), MAN2B2(1), MAN2C1(6), MANBA(6), NAGLU(3), NEU2(1), NEU3(1), SPAM1(1) 7593192 78 31 77 26 27 18 2 23 8 0 0.305 1.000 1.000 418 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 49 AKT1(2), AKT2(5), BRD4(4), CBL(2), CDKN2A(1), F2RL2(2), FLOT1(3), GRB2(2), GSK3A(2), GSK3B(7), IGFBP1(2), INPPL1(3), IRS1(5), IRS4(11), LNPEP(6), MAPK1(2), MAPK3(2), PARD3(5), PIK3CA(33), PIK3CD(2), PIK3R1(5), PPYR1(1), PTEN(6), PTPN1(4), RAF1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SERPINB6(1), SHC1(3), SLC2A4(3), SORBS1(7), SOS1(5), SOS2(9), YWHAB(2), YWHAE(3), YWHAQ(1) 13095131 170 64 151 43 49 48 5 50 17 1 0.0166 1.000 1.000 419 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(1), CALCR(3), CALCRL(5), CD97(3), CRHR1(1), CRHR2(4), ELTD1(5), EMR1(5), EMR2(2), GHRHR(2), GLP1R(2), GLP2R(3), GPR64(5), LPHN1(3), LPHN2(10), LPHN3(10), SCTR(3), VIPR1(3), VIPR2(3) 5907561 73 35 71 25 25 14 1 24 9 0 0.413 1.000 1.000 420 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 53 ABP1(1), ACAT1(1), ACAT2(2), ACMSD(3), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(5), CAT(2), CYP19A1(5), CYP1A1(6), CYP1A2(2), CYP2A13(6), CYP2A6(3), CYP2A7(5), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2F1(3), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), CYP4B1(8), CYP4F8(4), CYP51A1(3), DDC(1), ECHS1(2), EHHADH(2), GCDH(3), HAAO(2), HADHA(2), KMO(3), KYNU(6), MAOA(2), SDS(2), TDO2(2), TPH1(1), WARS(1), WARS2(2) 12102127 152 54 152 38 57 36 2 45 11 1 0.0119 1.000 1.000 421 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(7), AZIN1(2), BTG1(1), CBX3(1), CLOCK(5), CRY1(2), CRY2(1), DNAJA1(1), EIF4G2(7), ETV6(4), GFRA1(3), GSTM3(2), HERPUD1(1), HSPA8(3), IDI1(1), MYF6(1), NCKAP1(8), NCOA4(3), NR1D2(3), PER1(1), PER2(2), PPP1R3C(2), PSMA4(2), SF3A3(1), SUMO3(1), TUBB3(1), UCP3(2), UGP2(5), ZFR(1) 8212379 74 29 72 17 33 14 3 16 8 0 0.0410 1.000 1.000 422 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 34 BET1(1), BNIP1(1), GOSR1(2), GOSR2(2), SEC22B(2), SNAP23(1), SNAP25(1), SNAP29(3), STX11(1), STX12(3), STX16(3), STX19(1), STX2(2), STX3(2), STX4(2), STX5(3), STX6(1), STX7(2), STX8(2), TSNARE1(1), VAMP1(1), VAMP3(1), VAMP4(2), VAMP5(2), VAMP8(1), VTI1A(1), VTI1B(1) 3635992 45 22 44 14 19 4 0 12 10 0 0.477 1.000 1.000 423 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(5), CASP8(11), CD14(1), CHUK(4), CXCL11(2), CXCL9(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IKBKB(2), IKBKE(3), IL12B(2), IL6(1), IRAK1(1), IRAK4(2), IRF5(3), LBP(1), LY96(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K7(2), MAP3K8(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK8(2), MAPK9(3), MYD88(1), NFKB1(3), NFKB2(2), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), RELA(2), RIPK1(2), SPP1(1), STAT1(6), TBK1(5), TICAM1(1), TIRAP(1), TLR1(2), TLR2(2), TLR3(4), TLR4(7), TLR5(3), TLR6(2), TLR7(4), TLR8(3), TLR9(4), TOLLIP(1), TRAF3(4), TRAF6(4) 19778260 227 75 210 58 54 64 12 71 26 0 0.0112 1.000 1.000 424 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(6), DLG4(2), EPHB2(7), F2(2), F2RL2(2), MAP2K5(2), MAPK1(2), MAPK7(3), MAPK8(2), MYEF2(7), PLD1(8), PLD2(1), PLD3(5), PTK2(5), RAF1(4), RASAL1(1), SRC(3), TEC(1), VAV1(11) 6126302 74 36 72 24 36 18 1 14 5 0 0.241 1.000 1.000 425 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(1), ACY1(2), ADC(1), ALDH18A1(5), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(4), ASS1(1), CPS1(8), GATM(1), MAOA(2), ODC1(2), OTC(4), SAT1(4), SAT2(1), SMS(2) 6616344 67 31 65 23 21 21 0 17 8 0 0.436 1.000 1.000 426 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CHUK(4), EGR2(6), EGR3(2), GNAQ(3), MAP3K1(6), NFATC1(1), NFATC2(3), NFKB1(3), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RELA(2), SYT1(1), VIPR2(3) 6078978 53 29 52 16 25 9 2 8 9 0 0.167 1.000 1.000 427 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(5), BCL10(3), CARD11(6), CBL(2), CBLB(6), CD247(2), CD28(1), CD3D(1), CD3G(2), CD4(2), CD40LG(6), CD8B(2), CDK4(2), CHUK(4), CTLA4(1), FYN(4), GRAP2(2), GRB2(2), ICOS(1), IFNG(1), IKBKB(2), IL10(1), IL2(3), IL4(3), ITK(8), KRAS(58), LCK(2), LCP2(2), MALT1(6), MAP3K14(2), MAP3K8(2), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NRAS(15), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKCQ(4), PTPN6(4), PTPRC(9), RASGRP1(2), RHOA(4), SOS1(5), SOS2(9), TEC(1), VAV1(11), VAV2(2), VAV3(10), ZAP70(4) 22423864 335 115 260 86 92 100 11 106 26 0 0.000723 1.000 1.000 428 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(4), AARS2(6), CARS(5), CARS2(1), DARS(3), DARS2(2), EPRS(9), FARS2(4), FARSA(1), FARSB(7), GARS(3), HARS(2), HARS2(2), IARS(5), IARS2(6), KARS(3), LARS(4), LARS2(2), MARS(3), MTFMT(1), NARS(2), NARS2(3), QARS(7), RARS(2), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(4), VARS(1), VARS2(6), WARS(1), WARS2(2), YARS(2), YARS2(3) 12175090 115 43 115 19 45 23 2 29 16 0 0.00240 1.000 1.000 429 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), GRB2(2), HSPB2(1), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K5(5), MAP3K7(2), MAP3K9(2), MAPK14(3), MAPKAPK2(3), MAPKAPK5(1), MAX(1), MEF2A(3), MEF2C(7), MEF2D(1), MKNK1(1), PLA2G4A(5), RIPK1(2), RPS6KA5(3), SHC1(3), STAT1(6), TGFB1(1), TGFB2(5), TGFBR1(6), TRADD(1), TRAF2(1) 8035769 83 32 80 25 31 22 3 18 9 0 0.212 1.000 1.000 430 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), APC(121), APC2(1), ARAF(3), ARHGEF1(4), ARHGEF12(7), ARHGEF4(3), ARHGEF6(7), ARHGEF7(7), ARPC1A(5), ARPC1B(2), ARPC2(1), ARPC5(1), ARPC5L(1), BDKRB2(2), BRAF(21), CD14(1), CFL1(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CRKL(2), CSK(1), CYFIP1(5), CYFIP2(4), DIAPH1(1), DIAPH2(9), DIAPH3(3), DOCK1(5), EGF(3), EGFR(10), EZR(2), F2(2), FGD1(6), FGD3(1), FGF1(2), FGF11(2), FGF12(2), FGF13(2), FGF14(5), FGF17(1), FGF20(1), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(3), FGFR2(1), FGFR3(2), FGFR4(2), FN1(17), GIT1(2), GNA12(2), GNA13(2), GRLF1(7), IQGAP1(10), IQGAP2(9), IQGAP3(11), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAD(7), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(4), ITGB1(6), ITGB2(4), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), KRAS(58), LIMK1(4), LIMK2(4), MAP2K1(3), MAPK1(2), MAPK3(2), MOS(2), MRAS(1), MSN(3), MYH10(8), MYH14(9), MYH9(9), MYL2(1), MYL7(1), MYLK(11), MYLK2(2), NCKAP1(8), NCKAP1L(7), NRAS(15), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PDGFA(1), PDGFRA(13), PDGFRB(5), PFN2(1), PFN4(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP1R12B(5), PTK2(5), RAF1(4), RDX(2), RHOA(4), ROCK1(8), ROCK2(2), RRAS2(1), SCIN(2), SLC9A1(2), SOS1(5), SOS2(9), SSH1(4), SSH2(4), TIAM1(12), TIAM2(14), TMSL3(1), VAV1(11), VAV2(2), VAV3(10), VCL(1), WAS(1), WASF1(1), WASF2(2), WASL(5) 60757022 854 149 720 208 260 176 23 237 122 36 5.29e-08 1.000 1.000 431 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 247 ACVR1B(13), ACVR1C(2), AKT1(2), AKT2(5), ARRB1(1), BDNF(1), BRAF(21), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1F(12), CACNA1G(10), CACNA1H(2), CACNA1I(3), CACNA1S(10), CACNA2D1(8), CACNA2D2(1), CACNA2D3(3), CACNA2D4(3), CACNB1(1), CACNB2(5), CACNB3(1), CACNG1(2), CACNG2(2), CACNG3(5), CACNG4(2), CACNG5(5), CACNG7(3), CACNG8(1), CASP3(1), CD14(1), CDC25B(5), CHUK(4), CRKL(2), DUSP1(2), DUSP10(4), DUSP16(3), DUSP3(1), DUSP4(1), DUSP5(1), DUSP6(4), DUSP7(1), DUSP9(1), ECSIT(2), EGF(3), EGFR(10), ELK4(1), FASLG(1), FGF1(2), FGF11(2), FGF12(2), FGF13(2), FGF14(5), FGF17(1), FGF20(1), FGF21(1), FGF23(1), FGF3(1), FGF5(2), FGF6(3), FGF7(1), FGF8(1), FGF9(1), FGFR1(3), FGFR2(1), FGFR3(2), FGFR4(2), FLNA(2), FLNB(14), FLNC(11), GNA12(2), GRB2(2), IKBKB(2), IL1A(1), IL1R1(3), IL1R2(3), KRAS(58), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K5(2), MAP2K6(2), MAP3K1(6), MAP3K10(2), MAP3K12(4), MAP3K13(8), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K6(6), MAP3K7(2), MAP3K8(2), MAP4K1(2), MAP4K3(3), MAP4K4(5), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK7(3), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAPT(4), MAX(1), MEF2C(7), MKNK1(1), MKNK2(2), MOS(2), MRAS(1), NF1(5), NFATC2(3), NFATC4(4), NFKB1(3), NFKB2(2), NLK(1), NR4A1(2), NRAS(15), NTF3(1), NTRK1(6), NTRK2(3), PAK1(4), PAK2(2), PDGFA(1), PDGFRA(13), PDGFRB(5), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PPM1A(7), PPM1B(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PPP5C(2), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PTPN5(1), PTPN7(1), PTPRR(1), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF2(8), RASA1(5), RASA2(1), RASGRF1(9), RASGRF2(5), RASGRP1(2), RASGRP2(5), RASGRP3(4), RASGRP4(1), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA5(3), RPS6KA6(5), RRAS2(1), SOS1(5), SOS2(9), SRF(3), STK3(3), STK4(3), STMN1(1), TAOK1(5), TAOK2(2), TAOK3(4), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TNFRSF1A(1), TP53(76), TRAF2(1), TRAF6(4), ZAK(4) 61949649 807 145 695 232 291 182 14 225 93 2 4.99e-05 1.000 1.000 432 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), AKT1(2), AKT2(5), ARHGAP5(6), BAD(1), BCL2(1), BIRC2(2), BIRC3(2), BRAF(21), CAPN2(5), CAV2(1), CAV3(2), CCND2(1), CCND3(1), CHAD(6), COL11A1(18), COL11A2(10), COL1A1(11), COL1A2(16), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COL6A6(15), COMP(2), CRKL(2), CTNNB1(8), DIAPH1(1), DOCK1(5), EGF(3), EGFR(10), ERBB2(6), FARP2(5), FLNA(2), FLNB(14), FLNC(11), FLT1(9), FN1(17), FYN(4), GRB2(2), GRLF1(7), GSK3B(7), HGF(5), IBSP(3), IGF1(2), IGF1R(7), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAV(1), ITGB1(6), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), KDR(8), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), MET(4), MYL2(1), MYL7(1), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PARVA(1), PARVB(5), PARVG(3), PDGFA(1), PDGFC(2), PDGFD(3), PDGFRA(13), PDGFRB(5), PDPK1(1), PGF(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP5K1C(3), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PRKCA(2), PRKCG(8), PTEN(6), PTK2(5), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF1(4), RELN(24), RHOA(4), ROCK1(8), ROCK2(2), SHC1(3), SHC3(1), SHC4(5), SOS1(5), SOS2(9), SPP1(1), SRC(3), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TLN1(5), TLN2(5), TNC(13), TNN(15), TNR(19), TNXB(14), VASP(3), VAV1(11), VAV2(2), VAV3(10), VCL(1), VEGFA(2), VEGFB(2), VEGFC(3), VTN(3), VWF(10) 81395410 978 133 936 332 339 235 23 274 105 2 0.0124 1.000 1.000 433 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(1), ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(4), ADRA2A(3), ADRB1(2), ADRB3(1), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), C5AR1(2), CALCR(3), CALCRL(5), CCKAR(1), CCKBR(3), CGA(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CNR1(3), CRHR1(1), CRHR2(4), CTSG(2), CYSLTR1(3), CYSLTR2(3), DRD1(1), DRD2(3), DRD3(3), DRD5(2), EDNRA(4), EDNRB(7), F2(2), F2RL2(2), FPR1(2), FSHB(1), FSHR(6), GABBR1(4), GABBR2(3), GABRA1(2), GABRA2(6), GABRA3(4), GABRA4(6), GABRA5(8), GABRA6(4), GABRB1(6), GABRB2(4), GABRB3(5), GABRE(5), GABRG1(7), GABRG2(8), GABRG3(5), GABRP(2), GABRQ(7), GABRR1(2), GABRR2(3), GALR1(1), GH1(1), GH2(1), GHR(6), GHRHR(2), GHSR(5), GLP1R(2), GLP2R(3), GLRA1(2), GLRA2(2), GLRA3(7), GLRB(6), GNRHR(4), GPR156(6), GPR50(5), GPR63(2), GPR83(1), GRIA1(18), GRIA2(10), GRIA3(5), GRIA4(12), GRID1(15), GRID2(10), GRIK1(5), GRIK2(10), GRIK3(15), GRIK4(11), GRIK5(5), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), GRIN3A(3), GRM1(9), GRM2(3), GRM3(5), GRM4(7), GRM5(8), GRM6(9), GRM7(7), GRM8(7), GRPR(3), GZMA(2), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HRH4(2), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), LEP(1), LEPR(5), LHB(1), LHCGR(4), MAS1(1), MC2R(2), MC3R(1), MC4R(3), MC5R(4), MCHR1(6), MCHR2(2), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(6), NPBWR1(3), NPFFR2(3), NPY1R(4), NPY2R(5), NPY5R(1), NR3C1(3), NTSR1(1), NTSR2(4), OPRD1(1), OPRK1(5), OPRM1(1), OXTR(2), P2RX1(1), P2RX2(1), P2RX3(2), P2RX4(2), P2RX5(1), P2RX7(2), P2RY1(3), P2RY10(6), P2RY13(2), P2RY14(4), P2RY2(2), P2RY4(6), PARD3(5), PPYR1(1), PRL(2), PRLR(2), PRSS1(3), PRSS3(4), PTAFR(1), PTGER2(1), PTGER3(6), PTGFR(6), PTGIR(1), PTH2R(6), RXFP1(2), RXFP2(8), SCTR(3), SSTR1(4), SSTR2(2), SSTR4(2), TAAR1(3), TAAR2(2), TAAR5(5), TAAR6(2), TAAR8(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(4), THRA(2), THRB(4), TRHR(6), TRPV1(3), TSHR(6), VIPR1(3), VIPR2(3) 48657115 748 125 743 273 292 161 17 217 61 0 0.0632 1.000 1.000 434 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(5), ABLIM2(4), ABLIM3(5), ARHGEF12(7), CFL1(1), CXCL12(1), CXCR4(3), DCC(14), DPYSL2(3), DPYSL5(1), EFNA3(1), EFNA4(1), EFNA5(2), EFNB1(3), EFNB3(2), EPHA1(3), EPHA2(5), EPHA3(14), EPHA4(4), EPHA5(11), EPHA6(5), EPHA7(7), EPHA8(5), EPHB1(6), EPHB2(7), EPHB3(2), EPHB4(2), EPHB6(4), FYN(4), GNAI1(3), GSK3B(7), ITGB1(6), KRAS(58), L1CAM(2), LIMK1(4), LIMK2(4), LRRC4C(6), MAPK1(2), MAPK3(2), MET(4), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NGEF(1), NRAS(15), NRP1(1), NTN1(4), NTN4(4), NTNG1(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PLXNA1(2), PLXNA2(5), PLXNA3(1), PLXNB1(3), PLXNB2(2), PLXNB3(2), PLXNC1(7), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PTK2(5), RASA1(5), RGS3(8), RHOA(4), RND1(1), ROBO1(15), ROBO2(15), ROBO3(2), ROCK1(8), ROCK2(2), SEMA3A(6), SEMA3B(1), SEMA3C(2), SEMA3D(9), SEMA3E(5), SEMA3F(1), SEMA3G(3), SEMA4A(2), SEMA4B(1), SEMA4D(12), SEMA4F(5), SEMA4G(5), SEMA5A(7), SEMA5B(7), SEMA6A(2), SEMA6C(2), SEMA6D(5), SEMA7A(2), SLIT1(9), SLIT2(12), SLIT3(7), SRGAP1(7), SRGAP2(3), SRGAP3(3), UNC5A(1), UNC5B(5), UNC5C(9), UNC5D(9) 42571303 531 124 468 159 182 130 4 159 56 0 0.00349 1.000 1.000 435 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 167 ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY7(3), ADCY8(11), ADCY9(4), ADORA2A(3), ADORA2B(1), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRB1(2), ADRB3(1), AGTR1(3), ATP2A1(6), ATP2A2(5), ATP2A3(3), ATP2B1(7), ATP2B2(7), ATP2B3(4), ATP2B4(5), AVPR1A(3), AVPR1B(3), BDKRB2(2), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1F(12), CACNA1G(10), CACNA1H(2), CACNA1I(3), CACNA1S(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CCKAR(1), CCKBR(3), CD38(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CYSLTR1(3), CYSLTR2(3), DRD1(1), EDNRA(4), EDNRB(7), EGFR(10), ERBB2(6), ERBB3(11), ERBB4(16), GNA11(1), GNA14(5), GNA15(3), GNAL(3), GNAQ(3), GNAS(6), GRIN1(1), GRIN2A(15), GRIN2C(2), GRIN2D(3), GRM1(9), GRM5(8), GRPR(3), HRH1(1), HRH2(4), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), LHCGR(4), MYLK(11), MYLK2(2), NOS1(5), NOS3(2), NTSR1(1), OXTR(2), P2RX1(1), P2RX2(1), P2RX3(2), P2RX4(2), P2RX5(1), P2RX7(2), PDE1A(3), PDE1B(2), PDE1C(7), PDGFRA(13), PDGFRB(5), PHKA1(4), PHKA2(5), PHKB(4), PHKG2(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PPID(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), PTAFR(1), PTGER3(6), PTGFR(6), PTK2B(1), RYR1(19), RYR2(48), RYR3(31), SLC25A4(1), SLC25A5(1), SLC8A1(11), SLC8A2(3), SLC8A3(4), SPHK2(1), TACR1(2), TACR2(1), TACR3(4), TNNC2(1), TRHR(6), TRPC1(5), VDAC1(1), VDAC3(1) 57208356 727 123 721 290 302 167 17 180 59 2 0.363 1.000 1.000 436 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADRB1(2), CSNK1D(3), DRD1(1), DRD2(3), EGF(3), EGFR(10), GJA1(3), GNA11(1), GNAI1(3), GNAQ(3), GNAS(6), GRB2(2), GRM1(9), GRM5(8), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HTR2A(2), HTR2B(1), HTR2C(6), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), MAP2K1(3), MAP2K5(2), MAP3K2(2), MAPK1(2), MAPK3(2), MAPK7(3), NPR1(6), NPR2(9), NRAS(15), PDGFA(1), PDGFC(2), PDGFD(3), PDGFRA(13), PDGFRB(5), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKG1(4), PRKG2(3), PRKX(2), RAF1(4), SOS1(5), SOS2(9), SRC(3), TJP1(5), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2) 28695023 432 123 372 142 154 105 11 133 28 1 0.0770 1.000 1.000 437 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CREB1(1), CREB3(2), CREB3L1(3), CREB3L2(3), CREB3L3(1), CREB3L4(1), CREBBP(21), CTNNB1(8), DCT(9), DVL2(8), DVL3(2), EDN1(1), EDNRB(7), EP300(13), FZD10(4), FZD2(2), FZD3(10), FZD4(1), FZD6(3), FZD7(3), FZD8(1), GNAI1(3), GNAO1(5), GNAQ(3), GNAS(6), GSK3B(7), KIT(6), KITLG(2), KRAS(58), LEF1(4), MAP2K1(3), MAPK1(2), MAPK3(2), MITF(2), NRAS(15), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), POMC(2), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), RAF1(4), TCF7(3), TCF7L1(3), TCF7L2(13), TYR(2), TYRP1(2), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1) 24015597 376 120 315 108 128 102 6 106 34 0 0.000912 1.000 1.000 438 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 131 ACACA(14), ACACB(14), AKT1(2), AKT2(5), ARAF(3), BAD(1), BRAF(21), CBL(2), CBLB(6), CRKL(2), EXOC7(1), FASN(1), FBP2(2), FLOT1(3), FOXO1(1), G6PC(3), GCK(1), GRB2(2), GSK3B(7), GYS1(1), GYS2(8), IKBKB(2), INPP5D(2), INSR(5), IRS1(5), IRS4(11), KRAS(58), LIPE(3), MAP2K1(3), MAPK1(2), MAPK10(4), MAPK3(2), MAPK8(2), MAPK9(3), MKNK1(1), MKNK2(2), NRAS(15), PCK2(3), PDE3A(5), PDE3B(2), PDPK1(1), PFKL(1), PFKM(1), PFKP(2), PHKA1(4), PHKA2(5), PHKB(4), PHKG2(2), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PKM2(2), PPARGC1A(5), PPP1CB(1), PPP1CC(1), PPP1R3A(8), PPP1R3B(1), PPP1R3C(2), PPP1R3D(1), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAG3(4), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCI(4), PRKX(2), PTPN1(4), PTPRF(8), PYGB(4), PYGL(2), PYGM(2), RAF1(4), RAPGEF1(4), RPS6KB1(3), RPS6KB2(1), SHC1(3), SHC3(1), SHC4(5), SLC2A4(3), SOCS2(2), SORBS1(7), SOS1(5), SOS2(9), SREBF1(1), TSC1(3), TSC2(1) 35659078 429 119 334 120 112 123 9 154 31 0 0.00223 1.000 1.000 439 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 ACTB(2), CHAD(6), COL11A1(18), COL11A2(10), COL17A1(6), COL1A1(11), COL1A2(16), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COL6A6(15), COMP(2), DES(1), DSC1(7), DSC2(2), DSC3(3), DSG1(6), DSG2(5), DSG3(8), DSG4(5), FN1(17), GJA1(3), GJA10(5), GJA4(2), GJA5(3), GJA8(4), GJA9(3), GJB1(3), GJB3(3), GJB4(1), GJB7(1), GJC1(4), GJC2(1), GJC3(1), GJD4(2), IBSP(3), INA(2), ITGA6(3), ITGB4(2), KRT1(3), KRT10(2), KRT12(1), KRT13(4), KRT15(1), KRT16(2), KRT17(2), KRT18(2), KRT19(2), KRT2(1), KRT23(1), KRT24(1), KRT25(3), KRT27(1), KRT28(1), KRT3(5), KRT31(4), KRT32(1), KRT33A(2), KRT33B(4), KRT34(4), KRT35(1), KRT36(2), KRT37(3), KRT4(2), KRT5(3), KRT6A(3), KRT6B(2), KRT6C(2), KRT7(1), KRT71(3), KRT72(5), KRT73(2), KRT74(2), KRT75(5), KRT76(2), KRT77(1), KRT78(3), KRT79(2), KRT8(1), KRT81(1), KRT82(4), KRT83(1), KRT84(5), KRT85(5), KRT9(4), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), LMNB1(2), LMNB2(1), NES(6), PRPH(1), RELN(24), SPP1(1), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TNC(13), TNN(15), TNR(19), TNXB(14), VIM(2), VTN(3), VWF(10) 54306145 661 118 658 246 264 152 9 177 59 0 0.160 1.000 1.000 440 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 ARAF(3), BRAF(21), C7orf16(4), CACNA1A(8), CRHR1(1), GNA11(1), GNA12(2), GNA13(2), GNAI1(3), GNAO1(5), GNAQ(3), GNAS(6), GNAZ(1), GRIA1(18), GRIA2(10), GRIA3(5), GRID2(10), GRM1(9), GRM5(8), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), IGF1(2), IGF1R(7), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), LYN(4), MAP2K1(3), MAPK1(2), MAPK3(2), NOS1(5), NOS3(2), NPR1(6), NPR2(9), NRAS(15), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PRKCA(2), PRKCG(8), PRKG1(4), PRKG2(3), RAF1(4), RYR1(19) 24097119 397 118 317 118 129 105 8 132 23 0 0.0207 1.000 1.000 441 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), AKT1(2), AKT2(5), AMOTL1(10), ASH1L(17), CASK(3), CDK4(2), CGN(6), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CSDA(2), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), EPB41(3), EPB41L1(8), EPB41L2(6), EPB41L3(15), EXOC4(4), F11R(1), GNAI1(3), HCLS1(7), IGSF5(6), INADL(3), JAM3(3), KRAS(58), LLGL1(1), MAGI1(10), MAGI2(6), MAGI3(4), MLLT4(3), MPDZ(7), MPP5(3), MRAS(1), MYH1(8), MYH10(8), MYH11(22), MYH13(10), MYH14(9), MYH15(8), MYH2(9), MYH3(9), MYH4(11), MYH6(8), MYH7(7), MYH7B(4), MYH8(17), MYH9(9), MYL2(1), MYL7(1), NRAS(15), OCLN(1), PARD3(5), PARD6G(1), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), PPP2R3A(3), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PTEN(6), RAB3B(1), RHOA(4), RRAS2(1), SPTAN1(9), SRC(3), SYMPK(5), TJP1(5), TJP2(5), TJP3(1), YES1(1), ZAK(4) 42061602 533 113 468 145 204 127 10 144 45 3 0.000232 1.000 1.000 442 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), CACNA1C(10), CACNA1D(7), CACNA1F(12), CACNA1S(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CGA(1), EGFR(10), FSHB(1), GNA11(1), GNAQ(3), GNAS(6), GNRHR(4), GRB2(2), HBEGF(1), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), LHB(1), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK7(3), MAPK8(2), MAPK9(3), MMP14(4), MMP2(2), NRAS(15), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLD1(8), PLD2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCD(3), PRKX(2), PTK2B(1), RAF1(4), SOS1(5), SOS2(9), SRC(3) 28080251 377 113 315 115 120 99 11 122 25 0 0.0238 1.000 1.000 443 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(1), CD36(1), CD44(3), CD47(3), CHAD(6), COL11A1(18), COL11A2(10), COL1A1(11), COL1A2(16), COL2A1(8), COL3A1(10), COL4A1(12), COL4A2(3), COL4A4(8), COL4A6(15), COL5A1(13), COL5A2(10), COL5A3(5), COL6A3(31), COL6A6(15), DAG1(4), FN1(17), FNDC1(15), FNDC3A(5), FNDC4(1), GP5(5), GP6(1), HMMR(4), HSPG2(9), IBSP(3), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAV(1), ITGB1(6), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), LAMA1(22), LAMA2(22), LAMA3(12), LAMA4(9), LAMB1(8), LAMB2(2), LAMB3(9), LAMB4(12), LAMC1(7), LAMC2(7), LAMC3(6), RELN(24), SDC2(2), SDC3(2), SDC4(1), SPP1(1), SV2A(4), SV2B(4), SV2C(4), THBS1(8), THBS2(10), THBS3(2), THBS4(1), TNC(13), TNN(15), TNR(19), TNXB(14), VTN(3), VWF(10) 49583108 598 112 595 232 221 136 11 169 61 0 0.352 1.000 1.000 444 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(4), ADCY8(11), ARAF(3), BRAF(21), CACNA1C(10), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CREBBP(21), EP300(13), GNAQ(3), GRIA1(18), GRIA2(10), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), GRM1(9), GRM5(8), ITPR1(11), ITPR2(12), ITPR3(11), KRAS(58), MAP2K1(3), MAPK1(2), MAPK3(2), NRAS(15), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PPP1CB(1), PPP1CC(1), PPP1R12A(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PPP3R2(1), PRKACB(1), PRKACG(2), PRKCA(2), PRKCG(8), PRKX(2), RAF1(4), RAP1A(1), RAP1B(2), RAPGEF3(3), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA6(5) 21812621 362 111 284 102 116 100 11 110 25 0 0.00295 1.000 1.000 445 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), AKAP10(2), AKAP11(4), AKAP12(11), AKAP3(6), AKAP4(2), AKAP5(3), AKAP6(10), AKAP7(2), AKAP8(3), AKAP9(20), ARHGEF1(4), GNA11(1), GNA12(2), GNA13(2), GNA14(5), GNA15(3), GNAL(3), GNAO1(5), GNAQ(3), GNAZ(1), GNB1(1), GNB3(3), GNB5(1), GNG3(2), GNG7(1), ITPR1(11), KCNJ3(6), KRAS(58), NRAS(15), PDE1A(3), PDE1B(2), PDE1C(7), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE7A(3), PDE7B(3), PDE8A(1), PDE8B(6), PLCB3(3), PPP3CA(1), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCI(4), PRKCQ(4), PRKD1(10), PRKD3(6), RHOA(4), SLC9A1(2), USP5(3) 25761602 345 110 283 108 109 91 10 103 31 1 0.0286 1.000 1.000 446 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRB1(2), ADRB3(1), ANXA6(2), ARRB1(1), ATP1A4(6), ATP1B1(1), ATP2A2(5), ATP2A3(3), ATP2B1(7), ATP2B2(7), ATP2B3(4), CACNA1A(8), CACNA1B(7), CACNA1C(10), CACNA1D(7), CACNA1E(15), CACNA1S(10), CACNB1(1), CACNB3(1), CAMK1(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CASQ1(1), CASQ2(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), GJA1(3), GJA4(2), GJA5(3), GJB1(3), GJB3(3), GJB4(1), GNA11(1), GNAO1(5), GNAQ(3), GNAZ(1), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG7(1), GRK4(5), GRK5(3), GRK6(3), ITPR1(11), ITPR2(12), ITPR3(11), KCNB1(2), KCNJ3(6), KCNJ5(3), NME7(3), PEA15(1), PKIA(1), PKIB(1), PLCB3(3), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), PRKD1(10), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(1), RGS18(2), RGS2(1), RGS20(3), RGS3(8), RGS4(2), RGS6(3), RGS7(4), RGS9(4), RYR1(19), RYR2(48), RYR3(31), SLC8A1(11), SLC8A3(4), USP5(3), YWHAB(2), YWHAQ(1) 39658830 482 106 480 206 215 101 12 114 39 1 0.727 1.000 1.000 447 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 247 ACVR1(3), ACVR1B(13), ACVR2A(9), ACVR2B(3), AMHR2(2), BMP7(5), BMPR1A(4), BMPR1B(9), BMPR2(6), CCL13(1), CCL15(1), CCL18(1), CCL23(2), CCL27(3), CCL7(1), CCL8(1), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CCR9(4), CD27(3), CD40LG(6), CD70(5), CNTF(2), CNTFR(2), CSF1(1), CSF1R(3), CSF2RB(7), CSF3R(9), CX3CR1(1), CXCL11(2), CXCL12(1), CXCL14(1), CXCL5(1), CXCL6(1), CXCL9(2), CXCR4(3), EDA(1), EDA2R(2), EDAR(1), EGF(3), EGFR(10), FASLG(1), FLT1(9), FLT3(3), FLT3LG(1), FLT4(4), GDF5(1), GH1(1), GH2(1), GHR(6), HGF(5), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL10(1), IL10RA(1), IL10RB(4), IL11(1), IL11RA(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL13(1), IL13RA1(1), IL15(1), IL15RA(1), IL17A(1), IL17RA(5), IL17RB(1), IL18R1(8), IL18RAP(2), IL19(1), IL1A(1), IL1R1(3), IL1R2(3), IL2(3), IL20(2), IL20RA(4), IL21(2), IL21R(3), IL22(2), IL22RA1(1), IL23R(2), IL24(2), IL25(1), IL26(3), IL28RA(3), IL2RA(2), IL2RB(1), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL6ST(2), IL7(1), IL7R(2), IL9(1), INHBA(8), INHBB(1), INHBC(2), KDR(8), KIT(6), KITLG(2), LEP(1), LEPR(5), LIFR(19), LTB(1), LTBR(2), MET(4), MPL(1), NGFR(2), OSM(1), OSMR(4), PDGFC(2), PDGFRA(13), PDGFRB(5), PLEKHO2(5), PRL(2), PRLR(2), RELT(2), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), TNFRSF10A(3), TNFRSF10B(2), TNFRSF10C(6), TNFRSF11A(2), TNFRSF11B(4), TNFRSF13B(4), TNFRSF17(2), TNFRSF19(3), TNFRSF1A(1), TNFRSF21(4), TNFRSF4(1), TNFRSF8(1), TNFRSF9(2), TNFSF10(1), TNFSF11(1), TNFSF12(2), TNFSF13(2), TNFSF14(3), TNFSF15(3), TNFSF18(1), TNFSF4(1), TNFSF8(1), TPO(8), TSLP(2), VEGFA(2), VEGFB(2), VEGFC(3), XCL2(1) 39019725 494 100 483 161 161 110 10 146 66 1 0.0462 1.000 1.000 448 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA1(3), ACTA2(3), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADM(2), ARRB1(1), ATF1(1), ATF3(1), ATP2A2(5), ATP2A3(3), CACNB3(1), CALCA(4), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CORIN(10), CREB3(2), CRHR1(1), DGKZ(2), ETS2(2), GABPA(4), GABPB2(2), GBA2(5), GJA1(3), GNAQ(3), GNB1(1), GNB3(3), GNB4(3), GNB5(1), GNG3(2), GNG7(1), GRK4(5), GRK5(3), GRK6(3), GSTO1(1), GUCA2B(2), GUCY1A3(12), IGFBP1(2), IGFBP2(1), IGFBP3(2), IGFBP4(2), IL6(1), ITPR1(11), ITPR2(12), ITPR3(11), MYL2(1), MYLK2(2), NFKB1(3), NOS1(5), NOS3(2), OXTR(2), PDE4B(2), PDE4D(3), PKIA(1), PKIB(1), PLCB3(3), PLCD1(6), PLCG1(4), PLCG2(9), PRKACB(1), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCH(2), PRKCQ(4), PRKD1(10), RAMP1(1), RAMP3(3), RGS1(1), RGS10(1), RGS14(2), RGS16(2), RGS17(1), RGS18(2), RGS2(1), RGS20(3), RGS3(8), RGS4(2), RGS6(3), RGS7(4), RGS9(4), RYR1(19), RYR2(48), RYR3(31), SLC8A1(11), SP1(2), TNXB(14), USP5(3), YWHAB(2), YWHAQ(1) 36562487 440 97 436 165 188 93 12 107 40 0 0.256 1.000 1.000 449 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 146 AKT1(2), AKT2(5), BCL2L1(1), CBL(2), CBLB(6), CCND2(1), CCND3(1), CNTF(2), CNTFR(2), CREBBP(21), CSF2RB(7), CSF3R(9), EP300(13), GH1(1), GH2(1), GHR(6), GRB2(2), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), IFNAR1(3), IFNAR2(1), IFNB1(1), IFNG(1), IFNGR1(2), IFNGR2(1), IL10(1), IL10RA(1), IL10RB(4), IL11(1), IL11RA(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL13(1), IL13RA1(1), IL13RA2(2), IL15(1), IL15RA(1), IL19(1), IL2(3), IL20(2), IL20RA(4), IL21(2), IL21R(3), IL22(2), IL22RA1(1), IL23R(2), IL24(2), IL26(3), IL28RA(3), IL2RA(2), IL2RB(1), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL6ST(2), IL7(1), IL7R(2), IL9(1), IRF9(3), JAK1(3), JAK2(6), JAK3(6), LEP(1), LEPR(5), LIFR(19), MPL(1), OSM(1), OSMR(4), PIAS1(3), PIAS2(2), PIAS3(4), PIAS4(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIM1(1), PRL(2), PRLR(2), PTPN11(2), PTPN6(4), SOCS2(2), SOCS5(2), SOS1(5), SOS2(9), SPRED1(6), SPRED2(5), SPRY1(2), SPRY4(2), STAM(1), STAM2(2), STAT1(6), STAT2(5), STAT3(2), STAT5B(2), STAT6(2), TPO(8), TSLP(2), TYK2(1) 31536552 375 95 355 97 127 89 12 107 39 1 0.000482 1.000 1.000 450 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 163 ADORA1(5), ADORA2A(3), ADORA2B(1), ADORA3(3), ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRA2A(3), ADRB1(2), ADRB3(1), AGTR1(3), AGTR2(4), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), CCBP2(5), CCKAR(1), CCKBR(3), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CCR9(4), CCRL1(2), CHML(4), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), CMKLR1(2), CNR1(3), CX3CR1(1), CXCR4(3), DRD1(1), DRD2(3), DRD3(3), DRD5(2), EDNRA(4), EDNRB(7), F2RL2(2), FPR1(2), FSHR(6), GALR1(1), GALT(2), GHSR(5), GPR17(1), GPR173(2), GPR174(2), GPR37(6), GPR37L1(3), GPR4(1), GPR50(5), GPR6(5), GPR63(2), GPR77(1), GPR83(1), GPR85(1), GPR87(4), GRPR(3), HCRTR1(1), HCRTR2(1), HRH1(1), HRH2(4), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6), LHCGR(4), MAS1(1), MC3R(1), MC4R(3), MC5R(4), MLNR(3), MTNR1B(3), NMUR1(4), NMUR2(6), NPY1R(4), NPY2R(5), NPY5R(1), NTSR1(1), NTSR2(4), OPN1SW(3), OPN3(1), OPRD1(1), OPRK1(5), OPRM1(1), OR12D3(1), OR1C1(1), OR1F1(2), OR2H1(3), OR5V1(2), OR7A5(3), OR7C1(6), OR8B8(2), OXTR(2), P2RY1(3), P2RY10(6), P2RY12(3), P2RY13(2), P2RY14(4), P2RY2(2), PPYR1(1), PTAFR(1), PTGER2(1), PTGFR(6), PTGIR(1), RGR(2), RHO(2), RRH(2), SSTR1(4), SSTR2(2), SSTR4(2), TRHR(6) 26191993 356 94 357 124 147 86 6 90 27 0 0.0189 1.000 1.000 451 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(2), CADM1(8), CADM3(6), CD2(3), CD22(8), CD226(2), CD274(3), CD28(1), CD34(1), CD4(2), CD40LG(6), CD58(1), CD6(3), CD8B(2), CDH1(4), CDH2(16), CDH3(2), CDH4(7), CDH5(2), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CNTN1(12), CNTN2(5), CNTNAP1(6), CNTNAP2(8), CTLA4(1), ESAM(3), F11R(1), GLG1(4), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DRA(4), HLA-DRB1(1), HLA-E(1), HLA-F(1), HLA-G(1), ICAM1(2), ICAM2(1), ICOS(1), ITGA4(3), ITGA6(3), ITGA8(5), ITGA9(4), ITGAL(5), ITGAM(5), ITGAV(1), ITGB1(6), ITGB2(4), ITGB7(4), ITGB8(4), JAM3(3), L1CAM(2), MAG(5), MPZL1(1), NCAM1(2), NCAM2(9), NEGR1(4), NEO1(4), NFASC(13), NLGN1(4), NLGN2(1), NLGN3(4), NRCAM(6), NRXN1(21), NRXN2(5), NRXN3(16), OCLN(1), PDCD1LG2(1), PECAM1(1), PTPRC(9), PTPRF(8), PTPRM(19), PVR(1), PVRL1(4), PVRL2(3), PVRL3(1), SDC2(2), SDC3(2), SDC4(1), SELE(2), SELP(4), SELPLG(1), SIGLEC1(2), SPN(1), VCAM1(7), VCAN(23) 32555845 405 94 398 152 137 86 6 124 48 4 0.321 1.000 1.000 452 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(2), ACTB(2), ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), ACVR1B(13), ACVR1C(2), CDH1(4), CREBBP(21), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), CTNND1(5), EGFR(10), EP300(13), ERBB2(6), FARP2(5), FER(4), FGFR1(3), FYN(4), IGF1R(7), INSR(5), IQGAP1(10), LEF1(4), LMO7(18), MAP3K7(2), MAPK1(2), MAPK3(2), MET(4), MLLT4(3), NLK(1), PARD3(5), PTPN1(4), PTPN6(4), PTPRB(4), PTPRF(8), PTPRJ(3), PTPRM(19), PVRL1(4), PVRL2(3), PVRL3(1), PVRL4(4), RHOA(4), SMAD2(11), SMAD3(6), SMAD4(21), SNAI1(1), SNAI2(1), SORBS1(7), SRC(3), SSX2IP(3), TCF7(3), TCF7L1(3), TCF7L2(13), TGFBR1(6), TGFBR2(7), TJP1(5), VCL(1), WAS(1), WASF1(1), WASF2(2), WASF3(2), WASL(5), YES1(1) 26031191 377 93 366 100 133 99 5 91 48 1 0.000379 1.000 1.000 453 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(3), ACTA2(3), ACTN2(7), ACTN3(2), ACTN4(2), DES(1), DMD(36), FAM48A(4), MYBPC1(5), MYBPC2(4), MYBPC3(2), MYH3(9), MYH6(8), MYH7(7), MYH8(17), MYL1(1), MYL2(1), MYOM1(8), NEB(38), TMOD1(2), TNNC2(1), TNNI1(2), TNNI3(1), TNNT2(3), TPM1(2), TPM2(5), TPM3(2), TPM4(3), TTN(203), VIM(2) 25300292 384 93 373 113 129 83 6 131 29 6 0.0673 1.000 1.000 454 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(3), ACTN2(7), ACTN3(2), ACTN4(2), ARHGAP5(6), CDH5(2), CLDN10(2), CLDN11(1), CLDN15(1), CLDN16(4), CLDN17(5), CLDN18(2), CLDN19(1), CLDN6(2), CLDN7(2), CLDN8(3), CLDN9(1), CTNNA1(10), CTNNA2(10), CTNNA3(9), CTNNB1(8), CTNND1(5), CXCL12(1), CXCR4(3), CYBB(1), ESAM(3), EZR(2), F11R(1), GNAI1(3), GRLF1(7), ICAM1(2), ITGA4(3), ITGAL(5), ITGAM(5), ITGB1(6), ITGB2(4), ITK(8), JAM3(3), MAPK12(2), MAPK14(3), MLLT4(3), MMP2(2), MMP9(6), MSN(3), MYL2(1), MYL7(1), NCF1(1), NCF2(1), NCF4(2), NOX1(1), NOX3(5), OCLN(1), PECAM1(1), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PLCG1(4), PLCG2(9), PRKCA(2), PRKCG(8), PTK2(5), PTK2B(1), PTPN11(2), RAP1A(1), RAP1B(2), RAPGEF3(3), RAPGEF4(7), RASSF5(3), RHOA(4), RHOH(2), ROCK1(8), ROCK2(2), SIPA1(1), TXK(4), VASP(3), VAV1(11), VAV2(2), VAV3(10), VCAM1(7), VCL(1) 26896643 336 86 316 88 127 80 7 80 42 0 0.000720 1.000 1.000 455 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(3), ACTR2(1), ACTR3(2), AKT1(2), AKT2(5), ANGPTL2(8), ARHGEF6(7), ARHGEF7(7), BRAF(21), CDKN2A(1), CSE1L(4), DOCK1(5), EPHB2(7), FYN(4), GRB2(2), GRB7(1), GRLF1(7), ITGA1(3), ITGA10(3), ITGA11(2), ITGA2(5), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGB3BP(1), MAP2K4(9), MAP3K11(4), MAPK1(2), MAPK10(4), MAPK8(2), MAPK8IP1(2), MAPK8IP3(1), MAPK9(3), MRAS(1), MYLK(11), MYLK2(2), P4HB(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CB(2), PLCG1(4), PLCG2(9), PTEN(6), PTK2(5), RAF1(4), RHO(2), ROCK1(8), ROCK2(2), SHC1(3), SOS1(5), SOS2(9), SRC(3), TERF2IP(1), TLN1(5), TLN2(5), VASP(3), WAS(1) 26806905 304 86 264 93 94 77 8 90 34 1 0.0749 1.000 1.000 456 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADA(2), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADCY9(4), ADK(1), ADSL(7), ADSS(1), AK5(4), AK7(5), ALLC(3), AMPD1(6), AMPD2(4), AMPD3(2), ATIC(4), DCK(1), ENPP1(4), ENPP3(3), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(1), ENTPD6(1), FHIT(1), GART(3), GMPR(1), GMPR2(2), GMPS(5), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HPRT1(2), IMPDH1(1), IMPDH2(1), ITPA(2), NME6(3), NME7(3), NPR1(6), NPR2(9), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), NUDT9(2), PAPSS1(1), PAPSS2(2), PDE10A(6), PDE11A(7), PDE1A(3), PDE1C(7), PDE3B(2), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE5A(3), PDE6D(1), PDE7A(3), PDE7B(3), PDE8A(1), PDE8B(6), PDE9A(5), PFAS(1), PKM2(2), PNPT1(5), POLA1(5), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(5), POLR3GL(1), POLR3H(1), PPAT(3), PRIM2(6), PRPS1L1(1), PRPS2(2), RFC5(2), RRM1(1), RRM2(2), XDH(7) 36574806 390 83 387 129 126 105 11 95 53 0 0.0876 1.000 1.000 457 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1(3), ACVR1B(13), ACVRL1(3), AKT1(2), AURKB(1), BMPR1A(4), BMPR2(6), BUB1(4), CDKL1(2), CDKL2(4), CDS1(1), CDS2(4), CLK1(5), CLK4(2), COL4A3BP(3), CSNK2A1(4), CSNK2A2(2), CSNK2B(2), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), IMPA1(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPPL1(3), ITPKB(4), MAP3K10(2), MOS(2), NEK1(7), NEK3(4), OCRL(5), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3CA(33), PIK3CB(2), PIK3CG(12), PIM2(1), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCG1(4), PLCG2(9), PLK3(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), PRKD1(10), PRKG1(4), RAF1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), TGFBR1(6), VRK1(3) 24958187 309 83 290 76 119 83 7 77 23 0 0.000311 1.000 1.000 458 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 109 A4GNT(2), ALG10(3), ALG10B(4), ALG11(1), ALG12(2), ALG13(1), ALG2(3), ALG3(1), ALG6(3), ALG8(5), ALG9(1), B3GNT1(2), B3GNT2(1), B3GNT7(4), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT5(2), C1GALT1C1(2), CHPF(3), CHST1(6), CHST11(2), CHST12(2), CHST13(1), CHST14(1), CHST2(1), CHST4(5), CHSY1(5), DAD1(2), DDOST(2), DPAGT1(1), EXT1(10), EXTL1(3), EXTL2(3), EXTL3(7), FUT8(1), GALNT1(2), GALNT10(5), GALNT11(4), GALNT12(1), GALNT13(5), GALNT14(9), GALNT2(3), GALNT3(4), GALNT5(6), GALNT6(2), GALNT7(2), GALNT8(1), GALNT9(2), GALNTL1(3), GALNTL2(6), GALNTL4(1), GALNTL5(5), GANAB(4), GCNT1(3), GCNT3(2), GCNT4(5), HS2ST1(3), HS3ST1(1), HS3ST2(1), HS3ST3B1(2), HS3ST5(4), HS6ST2(2), HS6ST3(2), MAN1A1(4), MAN1A2(2), MAN1B1(2), MAN1C1(4), MAN2A1(8), MGAT1(1), MGAT3(2), MGAT4A(2), MGAT4B(1), MGAT5(3), MGAT5B(2), NDST1(3), NDST2(5), NDST3(7), NDST4(4), OGT(4), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST6GAL1(1), ST6GALNAC1(2), STT3B(4), UST(1), WBSCR17(17), XYLT1(4), XYLT2(2) 24364728 289 82 287 80 117 64 8 70 30 0 0.00621 1.000 1.000 459 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CDS1(1), CDS2(4), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), IMPA1(2), IMPA2(2), INPP1(2), INPP4A(2), INPP4B(5), INPP5A(2), INPP5B(1), INPP5D(2), INPPL1(3), ITGB1BP3(1), ITPK1(2), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), OCRL(5), PI4KA(11), PI4KB(2), PIK3C2A(2), PIK3C2B(3), PIK3C2G(7), PIK3C3(5), PIK3CA(33), PIK3CB(2), PIK3CD(2), PIK3CG(12), PIK3R1(5), PIK3R2(1), PIK3R5(1), PIP4K2A(2), PIP4K2B(2), PIP4K2C(3), PIP5K1A(3), PIP5K1B(1), PIP5K1C(3), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), PLCD1(6), PLCD3(2), PLCD4(2), PLCE1(7), PLCG1(4), PLCG2(9), PLCZ1(3), PRKCA(2), PRKCG(8), PTEN(6), PTPMT1(2), SYNJ1(8), SYNJ2(5) 26943337 293 79 274 78 114 71 9 67 31 1 0.00198 1.000 1.000 460 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1(3), ACVR1B(13), ACVR1C(2), ACVR2A(9), ACVR2B(3), ACVRL1(3), AMHR2(2), BMP4(1), BMP5(4), BMP6(3), BMP7(5), BMP8A(1), BMPR1A(4), BMPR1B(9), BMPR2(6), CHRD(5), COMP(2), CREBBP(21), CUL1(7), DCN(3), E2F4(1), E2F5(2), EP300(13), FST(2), GDF5(1), GDF6(2), IFNG(1), INHBA(8), INHBB(1), INHBC(2), LTBP1(8), MAPK1(2), MAPK3(2), NODAL(1), PITX2(2), PPP2CA(1), PPP2R1A(4), PPP2R1B(1), PPP2R2A(1), PPP2R2B(1), PPP2R2C(3), RBL1(3), RBL2(8), RHOA(4), ROCK1(8), ROCK2(2), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD2(11), SMAD3(6), SMAD4(21), SMAD9(2), SMURF1(1), SMURF2(2), SP1(2), TFDP1(4), TGFB1(1), TGFB2(5), TGFBR1(6), TGFBR2(7), THBS1(8), THBS2(10), THBS3(2), THBS4(1), ZFYVE16(9), ZFYVE9(6) 22130950 301 79 290 99 100 78 6 66 50 1 0.154 1.000 1.000 461 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADA(2), ADCY1(4), ADCY2(12), ADCY3(1), ADCY4(9), ADCY5(8), ADCY6(1), ADCY7(3), ADCY8(11), ADK(1), ADSL(7), ADSS(1), AK5(4), ALLC(3), AMPD1(6), AMPD2(4), AMPD3(2), ATIC(4), ATP1B1(1), ATP5A1(2), ATP5B(4), ATP5C1(2), ATP5D(1), ATP5F1(1), ATP5G3(1), ATP5J2(1), DCK(1), ENPP1(4), ENPP3(3), ENTPD1(2), FHIT(1), GART(3), GMPS(5), GUCY1A2(8), GUCY1A3(12), GUCY1B3(7), GUCY2C(7), GUCY2D(4), GUCY2F(7), HPRT1(2), IMPDH1(1), IMPDH2(1), ITPA(2), NPR1(6), NPR2(9), NT5E(2), NT5M(1), PAPSS1(1), PAPSS2(2), PDE1A(3), PDE4A(4), PDE4B(2), PDE4C(2), PDE4D(3), PDE5A(3), PDE6B(5), PDE6C(8), PDE7B(3), PDE8A(1), PDE9A(5), PFAS(1), PKM2(2), POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8), POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1), PPAT(3), PRPS1L1(1), PRPS2(2), RRM1(1), RRM2(2) 28594308 296 73 292 87 100 71 8 80 37 0 0.0391 1.000 1.000 462 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(17), ABCA10(7), ABCA12(22), ABCA13(23), ABCA3(5), ABCA4(10), ABCA5(15), ABCA6(12), ABCA7(5), ABCA8(10), ABCA9(12), ABCB1(6), ABCB10(3), ABCB11(8), ABCB4(8), ABCB5(10), ABCB6(3), ABCB7(3), ABCB8(4), ABCB9(2), ABCC1(8), ABCC10(7), ABCC11(9), ABCC12(7), ABCC2(11), ABCC3(5), ABCC4(9), ABCC5(5), ABCC6(5), ABCC8(7), ABCC9(7), ABCD1(3), ABCD2(8), ABCD3(3), ABCD4(5), ABCG1(5), ABCG2(5), ABCG4(3), ABCG5(1), ABCG8(4), CFTR(8), TAP1(3), TAP2(4) 25980958 317 72 315 96 100 74 7 94 40 2 0.0329 1.000 1.000 463 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(8), BDKRB2(2), C1QB(1), C1QC(3), C1R(2), C1S(3), C3(10), C3AR1(2), C4BPA(2), C5(9), C5AR1(2), C6(10), C7(2), C8A(3), C8B(9), C9(4), CD46(2), CD55(3), CFB(2), CFH(10), CFI(2), CPB2(1), CR1(7), CR2(9), F10(1), F11(4), F12(2), F13A1(8), F13B(3), F2(2), F3(1), F5(14), F7(2), F8(15), F9(6), FGA(11), FGB(1), FGG(4), KLKB1(4), KNG1(3), MASP1(9), MASP2(4), PLAT(4), PLAU(2), PLAUR(3), PLG(7), PROC(1), PROS1(3), SERPINA5(3), SERPINC1(3), SERPIND1(1), SERPINE1(1), SERPING1(3), THBD(2), VWF(10) 19926631 245 72 242 84 70 64 5 79 26 1 0.278 1.000 1.000 464 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), CAPN1(2), CAPN10(3), CAPN11(1), CAPN2(5), CAPN3(6), CAPN5(5), CAPN6(2), CAPN7(3), CAPN9(1), CAPNS1(1), CAV2(1), CAV3(2), CSK(1), DOCK1(5), FYN(4), GIT2(6), GRB2(2), ITGA10(3), ITGA11(2), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGA7(6), ITGA8(5), ITGA9(4), ITGAD(7), ITGAE(5), ITGAL(5), ITGAM(5), ITGAV(1), ITGAX(4), ITGB1(6), ITGB2(4), ITGB3(7), ITGB4(2), ITGB5(5), ITGB6(6), ITGB7(4), ITGB8(4), MAP2K1(3), MAP2K3(2), MAP2K6(2), MAPK10(4), MAPK12(2), MAPK4(1), MAPK6(2), MAPK7(3), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PDPK1(1), PIK3R2(1), PTK2(5), RAP1B(2), RAPGEF1(4), RHO(2), ROCK1(8), ROCK2(2), SHC1(3), SHC3(1), SORBS1(7), SOS1(5), SRC(3), TLN1(5), TNS1(11), VASP(3), VAV2(2), VAV3(10), VCL(1) 29338589 268 71 264 105 97 50 7 83 31 0 0.687 1.000 1.000 465 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), ACTR3(2), AKT1(2), AKT2(5), ANGPTL2(8), ARHGAP4(1), ARHGEF11(9), BTK(6), CFL1(1), GDI1(1), GDI2(1), INPPL1(3), ITPR1(11), ITPR2(12), ITPR3(11), LIMK1(4), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PIK3CA(33), PIK3CD(2), PIK3CG(12), PIK3R1(5), PITX2(2), PPP1R13B(5), PTEN(6), RACGAP1(2), RHO(2), ROCK1(8), ROCK2(2), RPS4X(1), SAG(1), WASF1(1), WASL(5) 15084082 192 71 176 53 59 53 7 52 20 1 0.0292 1.000 1.000 466 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 63 AKT1(2), AKT2(5), BAD(1), BCL2L1(1), CDK2(2), CDKN1B(1), CDKN2A(1), CREB1(1), CREB3(2), CREB5(2), EBP(2), ERBB4(16), F2RL2(2), GAB1(6), GRB2(2), GSK3A(2), GSK3B(7), IGF1(2), IGFBP1(2), INPPL1(3), IRS1(5), IRS4(11), MET(4), NOLC1(7), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PARD3(5), PIK3CA(33), PIK3CD(2), PPP1R13B(5), PREX1(14), PTEN(6), PTK2(5), PTPN1(4), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KB1(3), SHC1(3), SLC2A4(3), SOS1(5), SOS2(9), TSC1(3), TSC2(1), YWHAB(2), YWHAE(3), YWHAQ(1) 17007010 222 71 203 71 66 60 6 65 24 1 0.175 1.000 1.000 467 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 ACTB(2), BAD(1), BCL2(1), CABIN1(9), CAMK2B(2), CAMK4(2), CD3G(2), CDKN1A(1), CNR1(3), CREBBP(21), CSNK2A1(4), CSNK2B(2), CTLA4(1), EGR2(6), EGR3(2), EP300(13), FCER1A(2), GATA3(4), GATA4(1), GRLF1(7), GSK3A(2), GSK3B(7), ICOS(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL13(1), IL2(3), IL2RA(2), IL3(3), IL4(3), IL6(1), ITK(8), KPNA5(4), MAPK14(3), MAPK8(2), MAPK9(3), MEF2A(3), MEF2D(1), MYF5(2), NFAT5(5), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), NFKB2(2), NFKBIB(1), NFKBIE(2), NUP214(4), OPRD1(1), P2RX7(2), PAK1(4), PIN1(1), PPP3CB(4), PPP3CC(3), PPP3R1(1), PTPRC(9), RELA(2), SLA(4), SP1(2), SP3(2), TGFB1(1), TRAF2(1), TRPV6(9), VAV1(11), VAV2(2), VAV3(10) 19870908 234 64 230 77 84 63 6 53 28 0 0.0866 1.000 1.000 468 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(8), AMY2A(3), ASCC3(14), ATP13A2(3), DDX18(2), DDX19A(2), DDX23(4), DDX4(2), DDX41(2), DDX47(3), DDX50(2), DDX52(1), DDX54(5), DDX55(2), DDX56(3), DHX58(2), ENPP1(4), ENPP3(3), ENTPD7(4), EP400(18), ERCC2(4), ERCC3(6), G6PC(3), GANC(2), GBA3(3), GBE1(4), GCK(1), GPI(1), GUSB(2), GYS1(1), GYS2(8), HK1(6), HK2(3), HK3(4), IFIH1(5), MGAM(9), MOV10L1(6), PGM1(2), PGM3(4), PYGB(4), PYGL(2), PYGM(2), RAD54B(6), RAD54L(3), RUVBL2(1), SETX(11), SI(12), SKIV2L2(2), SMARCA2(8), SMARCA5(3), TREH(2), UGDH(3), UGP2(5), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2A1(8), UGT2A3(5), UGT2B10(1), UGT2B11(4), UGT2B15(2), UGT2B17(4), UGT2B28(2), UGT2B4(2), UGT2B7(4), UXS1(6) 26926036 278 64 274 85 96 76 3 69 33 1 0.0945 1.000 1.000 469 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 91 CD2BP2(4), CDC40(3), CLK3(2), CLK4(2), COL2A1(8), CPSF1(4), CPSF2(1), CPSF3(1), CPSF4(3), CSTF1(1), CSTF2T(5), CSTF3(2), DDX1(4), DDX20(3), DHX15(1), DHX16(6), DHX38(10), DHX8(6), DHX9(4), DICER1(7), DNAJC8(2), METTL3(3), NCBP1(4), NCBP2(1), NONO(1), NUDT21(1), NXF1(5), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(6), PPM1G(1), PRPF18(3), PRPF3(1), PRPF4(4), PRPF4B(3), PRPF8(9), PSKH1(1), PTBP1(1), PTBP2(3), RBM17(2), RBM5(1), RNGTT(6), RNMT(3), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(9), SF3B2(2), SF3B4(4), SFRS14(2), SFRS4(2), SNRPB2(1), SNRPE(2), SNRPN(2), SNURF(1), SPOP(2), SRPK1(7), SRPK2(2), SRRM1(8), SUPT5H(10), TXNL4A(1), U2AF1(1), U2AF2(2), XRN2(6) 23604331 210 63 210 60 69 53 3 51 34 0 0.198 1.000 1.000 470 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 80 ANPEP(5), CD14(1), CD19(3), CD1A(2), CD1D(1), CD1E(5), CD2(3), CD22(8), CD33(1), CD34(1), CD36(1), CD37(2), CD38(1), CD3D(1), CD3G(2), CD4(2), CD44(3), CD5(2), CD55(3), CD7(1), CD8B(2), CD9(1), CR1(7), CR2(9), CSF1(1), CSF1R(3), CSF3R(9), DNTT(5), FCER2(1), FCGR1A(1), FLT3(3), FLT3LG(1), GP5(5), GYPA(1), HLA-DRA(4), HLA-DRB1(1), IL11(1), IL11RA(1), IL1A(1), IL1R1(3), IL1R2(3), IL2RA(2), IL3(3), IL4(3), IL4R(1), IL5RA(4), IL6(1), IL6R(2), IL7(1), IL7R(2), ITGA1(3), ITGA2(5), ITGA2B(2), ITGA3(4), ITGA4(3), ITGA5(7), ITGA6(3), ITGAM(5), ITGB3(7), KIT(6), KITLG(2), MME(6), MS4A1(4), TFRC(2), THPO(1), TPO(8) 17487532 198 61 195 57 78 40 3 59 16 2 0.0204 1.000 1.000 471 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(3), AGTR2(4), ATP8A1(5), AVPR1A(3), AVPR1B(3), AVPR2(6), BDKRB2(2), BRS3(1), C3AR1(2), CCKAR(1), CCKBR(3), CCR1(5), CCR3(3), CCR5(1), CCR6(2), CCR7(1), CCR8(4), CX3CR1(1), CXCR4(3), EDNRA(4), EDNRB(7), FPR1(2), FSHR(6), GALR1(1), GALT(2), GHSR(5), GNRHR(4), GPR77(1), GRPR(3), LHCGR(4), MC2R(2), MC3R(1), MC4R(3), MC5R(4), NPY1R(4), NPY2R(5), NPY5R(1), NTSR1(1), NTSR2(4), OPRD1(1), OPRK1(5), OPRM1(1), OXTR(2), PPYR1(1), SSTR1(4), SSTR2(2), SSTR4(2), TAC4(1), TACR1(2), TACR2(1), TACR3(4), TRHR(6), TSHR(6) 11192250 155 61 156 61 58 36 3 50 8 0 0.327 1.000 1.000 472 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(2), CD28(1), CD3D(1), CSK(1), CTLA4(1), DAG1(4), EPHB2(7), FBXW7(33), GRAP2(2), GRB2(2), ITK(8), ITPKB(4), LCK(2), LCP2(2), MAPK1(2), NFAT5(5), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PLCG1(4), PTPRC(9), RAF1(4), RASGRP1(2), RASGRP2(5), RASGRP3(4), RASGRP4(1), SOS1(5), SOS2(9), VAV1(11), ZAP70(4) 12285711 157 61 142 50 64 30 8 40 15 0 0.178 1.000 1.000 473 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(3), ALG6(3), CCKBR(3), CCR3(3), CCR5(1), CELSR1(8), CELSR2(8), CELSR3(5), CHRM2(8), CHRM3(4), EDNRA(4), EMR2(2), EMR3(7), FSHR(6), GHRHR(2), GNRHR(4), GPR116(7), GPR132(1), GPR133(7), GPR143(2), GPR17(1), GPR55(1), GPR56(1), GPR61(4), GPR77(1), GPR84(3), GPR88(1), GRM1(9), GRPR(3), HRH4(2), LPHN2(10), LPHN3(10), NTSR1(1), OR2M4(8), OR8G2(1), P2RY13(2), PTGFR(6), SSTR2(2), TAAR5(5), TSHR(6), VN1R1(4) 14277695 169 60 166 60 65 36 4 47 17 0 0.270 1.000 1.000 474 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 ASH1L(17), ASH2L(2), C17orf79(1), CARM1(2), CTCFL(7), DOT1L(3), EED(2), EHMT1(2), EHMT2(1), EZH1(4), EZH2(4), FBXO11(4), JMJD6(2), KDM6A(1), MEN1(1), MLL(15), MLL2(14), MLL3(10), MLL4(8), MLL5(11), NSD1(11), OGT(4), PAXIP1(5), PPP1CB(1), PPP1CC(1), PRDM2(13), PRDM7(1), PRDM9(13), PRMT1(1), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), RBBP5(2), SATB1(1), SETD1A(7), SETD2(10), SETD7(2), SETD8(2), SETDB1(7), SETDB2(1), SMYD3(2), STK38(1), SUV39H1(1), SUV39H2(2), SUV420H1(5), SUZ12(2), WHSC1(6), WHSC1L1(4) 25849568 223 59 220 73 89 42 2 60 28 2 0.312 1.000 1.000 475 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 BRAF(21), CHUK(4), CREB1(1), GRB2(2), IKBKB(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K5(2), MAP2K6(2), MAP3K1(6), MAP3K10(2), MAP3K11(4), MAP3K12(4), MAP3K13(8), MAP3K14(2), MAP3K2(2), MAP3K3(2), MAP3K4(15), MAP3K5(5), MAP3K6(6), MAP3K7(2), MAP3K8(2), MAP3K9(2), MAP4K1(2), MAP4K3(3), MAP4K4(5), MAP4K5(2), MAPK1(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK3(2), MAPK4(1), MAPK6(2), MAPK7(3), MAPK8(2), MAPK9(3), MAPKAPK2(3), MAPKAPK3(1), MAPKAPK5(1), MAX(1), MEF2A(3), MEF2C(7), MEF2D(1), MKNK1(1), MKNK2(2), NFKB1(3), PAK1(4), PAK2(2), RAF1(4), RELA(2), RIPK1(2), RPS6KA1(1), RPS6KA2(8), RPS6KA3(3), RPS6KA5(3), RPS6KB1(3), RPS6KB2(1), SHC1(3), SP1(2), STAT1(6), TGFB1(1), TGFB2(5), TGFBR1(6), TRADD(1), TRAF2(1) 21028738 227 57 204 60 76 47 6 74 24 0 0.0307 1.000 1.000 476 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(3), AK3(1), CAD(10), CDA(1), CTPS(3), CTPS2(4), DCK(1), DCTD(3), DHODH(3), DPYD(8), DPYS(6), ENTPD1(2), ENTPD3(5), ENTPD4(5), ENTPD5(1), ENTPD6(1), ITPA(2), NME6(3), NME7(3), NT5C1A(1), NT5C1B(9), NT5C2(3), NT5C3(2), NT5E(2), NT5M(1), PNPT1(5), POLA1(5), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLR1A(7), POLR1B(6), POLR1C(2), POLR1D(2), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLR3A(7), POLR3B(5), POLR3GL(1), POLR3H(1), PRIM2(6), RFC5(2), RRM1(1), RRM2(2), TK1(1), TXNRD1(2), TXNRD2(2), TYMS(2), UCK2(1), UPB1(3), UPP2(1), UPRT(3) 18166669 193 56 192 47 55 56 4 56 22 0 0.00306 1.000 1.000 477 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP4(1), BMP5(4), BMP6(3), BMP7(5), BMP8A(1), BTRC(2), CSNK1A1(2), CSNK1A1L(5), CSNK1D(3), CSNK1G1(1), CSNK1G3(2), DHH(1), FBXW11(7), GLI1(3), GLI2(2), GLI3(9), GSK3B(7), HHIP(4), IHH(1), LRP2(39), PRKACB(1), PRKACG(2), PRKX(2), PTCH1(8), PTCH2(4), RAB23(1), STK36(4), SUFU(4), WNT1(1), WNT10B(3), WNT11(3), WNT16(2), WNT2B(1), WNT3(4), WNT3A(1), WNT4(1), WNT5A(3), WNT7A(2), WNT7B(2), WNT8A(1), WNT9A(2), WNT9B(1), ZIC2(1) 13343985 156 56 155 70 71 33 2 32 18 0 0.784 1.000 1.000 478 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(14), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADIPOQ(4), ADIPOR1(1), ADIPOR2(2), AKT1(2), AKT2(5), CAMKK1(1), CAMKK2(1), CD36(1), CHUK(4), CPT1A(5), CPT1B(5), CPT2(1), G6PC(3), IKBKB(2), IRS1(5), IRS4(11), JAK1(3), JAK2(6), JAK3(6), LEP(1), LEPR(5), MAPK10(4), MAPK8(2), MAPK9(3), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), NPY(1), PCK2(3), POMC(2), PPARA(1), PPARGC1A(5), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2), PRKAG3(4), PRKCQ(4), PTPN11(2), RELA(2), RXRA(1), RXRB(2), RXRG(3), SLC2A4(3), STAT3(2), TNFRSF1A(1), TRADD(1), TRAF2(1), TYK2(1) 18583021 179 55 178 65 55 48 4 54 17 1 0.418 1.000 1.000 479 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(1), ADAM17(6), ATP6AP1(2), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1B1(4), ATP6V1B2(1), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CHUK(4), CSK(1), EGFR(10), F11R(1), GIT1(2), HBEGF(1), IGSF5(6), IKBKB(2), JAM3(3), LYN(4), MAP2K4(9), MAP3K14(2), MAPK10(4), MAPK12(2), MAPK14(3), MAPK8(2), MAPK9(3), MET(4), NFKB1(3), NFKB2(2), NOD1(3), PAK1(4), PLCG1(4), PLCG2(9), PTPN11(2), PTPRZ1(12), RELA(2), SRC(3), TCIRG1(2), TJP1(5) 15603674 158 54 155 41 58 40 4 40 16 0 0.0183 1.000 1.000 480 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(10), AR(4), ESR1(12), ESR2(2), ESRRA(2), HNF4A(2), NR0B1(2), NR1D1(4), NR1D2(3), NR1H3(4), NR1I2(2), NR1I3(2), NR2C2(4), NR2E1(1), NR2F1(2), NR2F2(5), NR3C1(3), NR4A1(2), NR4A2(5), NR5A2(4), PGR(4), PPARA(1), PPARD(1), PPARG(1), RARB(7), RARG(5), ROR1(5), RORA(2), RORC(1), RXRA(1), RXRB(2), RXRG(3), THRA(2), THRB(4), VDR(1) 9387365 115 54 115 46 45 25 2 32 11 0 0.562 1.000 1.000 481 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(5), ASAH1(3), BRAF(21), DAG1(4), DRD2(3), EGFR(10), EPHB2(7), GRB2(2), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), KCNJ3(6), KCNJ5(3), KCNJ9(2), MAPK1(2), PIK3CB(2), PITX2(2), PLCB1(8), PLCB2(3), PLCB3(3), PLCB4(9), RAF1(4), RGS20(3), SHC1(3), SOS1(5), SOS2(9), SRC(3), STAT3(2), TERF2IP(1) 12738293 165 54 144 48 58 30 7 59 11 0 0.118 1.000 1.000 482 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(3), ANAPC10(2), ANAPC2(1), ANAPC4(1), ANAPC5(2), ANAPC7(4), BTRC(2), CDC16(3), CDC20(3), CDC23(6), CDC27(9), CUL1(7), CUL2(4), CUL3(1), FBXW11(7), FBXW7(33), ITCH(3), SKP1(1), SKP2(1), SMURF1(1), SMURF2(2), UBA1(1), UBE2C(2), UBE2D1(1), UBE2D4(1), UBE2E1(3), WWP1(5), WWP2(4) 9078799 113 53 97 30 40 15 2 36 20 0 0.189 1.000 1.000 483 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 47 ACCN1(6), ADCY4(9), ADCY6(1), ADCY8(11), CACNA1A(8), CACNA1B(7), GNAS(6), GNAT3(1), GNB1(1), GNB3(3), GNG3(2), GRM4(7), ITPR3(11), KCNB1(2), PDE1A(3), PLCB2(3), PRKACB(1), PRKACG(2), PRKX(2), SCNN1A(3), SCNN1B(3), SCNN1G(2), TAS1R1(6), TAS1R2(5), TAS2R1(1), TAS2R10(3), TAS2R13(3), TAS2R16(1), TAS2R3(1), TAS2R38(2), TAS2R39(2), TAS2R4(1), TAS2R41(1), TAS2R46(1), TAS2R5(1), TAS2R50(4), TAS2R60(1), TAS2R8(1), TAS2R9(1) 11864791 129 53 129 46 52 24 3 40 10 0 0.473 1.000 1.000 484 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 65 ACAA1(2), ACADM(3), ACOX1(3), ACOX2(2), ACOX3(5), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADIPOQ(4), APOA2(1), APOA5(1), AQP7(1), CD36(1), CPT1A(5), CPT1B(5), CPT2(1), CYP27A1(3), CYP4A11(2), CYP4A22(2), CYP7A1(4), CYP8B1(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(1), FABP5(1), FABP6(1), FADS2(3), GK(3), GK2(3), LPL(6), ME1(7), MMP1(1), NR1H3(4), OLR1(1), PCK2(3), PDPK1(1), PLTP(5), PPARA(1), PPARD(1), PPARG(1), RXRA(1), RXRB(2), RXRG(3), SCD(2), SCP2(3), SLC27A1(2), SLC27A2(2), SLC27A4(1), SLC27A5(3), SLC27A6(4), SORBS1(7), UCP1(1) 14519146 148 52 147 48 42 39 3 48 16 0 0.263 1.000 1.000 485 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(5), GRB2(2), IARS(5), IL13RA1(1), IL4(3), IL4R(1), INPP5D(2), JAK1(3), JAK2(6), JAK3(6), PIK3CA(33), PPP1R13B(5), RPS6KB1(3), SERPINA4(2), SHC1(3), SOS1(5), SOS2(9), SRC(3), STAT6(2), TYK2(1) 8055037 102 52 85 30 26 31 5 29 10 1 0.209 1.000 1.000 486 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 57 AADAT(1), ABP1(1), ACAT1(1), ACAT2(2), ACMSD(3), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), AOC2(4), AOC3(4), AOX1(5), CARM1(2), CAT(2), CYP1A1(6), CYP1A2(2), CYP1B1(2), DDC(1), ECHS1(2), EHHADH(2), GCDH(3), HAAO(2), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), INMT(1), KMO(3), KYNU(6), LCMT1(1), LCMT2(2), LNX1(7), MAOA(2), METTL2B(1), METTL6(5), NFX1(5), OGDH(4), OGDHL(8), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), TDO2(2), TPH1(1), TPH2(5), WARS(1), WARS2(2), WBSCR22(1) 13343849 139 51 139 42 53 37 0 38 11 0 0.0968 1.000 1.000 487 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 ADAM17(6), CREBBP(21), CTBP1(1), CTBP2(2), DLL1(1), DLL3(2), DLL4(1), DTX1(4), DTX2(3), DTX3L(3), DTX4(3), DVL2(8), DVL3(2), EP300(13), HDAC1(2), HDAC2(2), HES1(1), JAG1(7), MAML1(1), MAML2(3), MAML3(1), NCOR2(2), NCSTN(5), NOTCH2(11), NOTCH3(12), NOTCH4(3), NUMB(2), NUMBL(3), PSEN1(3), PSEN2(2), PTCRA(1), RBPJ(1), RBPJL(3), SNW1(4) 15002261 139 51 138 54 48 42 1 27 21 0 0.385 1.000 1.000 488 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 54 ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), AGK(2), AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), AKR1B1(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CEL(1), DAK(3), DGAT2(3), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), GK(3), GK2(3), GLA(4), GLB1(3), GPAM(2), LCT(15), LIPA(1), LIPC(3), LIPF(1), LIPG(2), LPL(6), PNLIP(5), PNLIPRP1(4), PNLIPRP2(1), PNPLA3(4), PPAP2B(1) 12921702 154 50 153 50 49 32 2 59 12 0 0.208 1.000 1.000 489 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 63 ACSS1(3), ACSS2(5), ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GALM(2), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKL(1), PFKM(1), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(6), PGM1(2), PGM3(4), PKM2(2), TPI1(1) 12661552 134 49 133 40 46 33 1 46 8 0 0.0781 1.000 1.000 490 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(5), CARM1(2), DBH(4), DCT(9), DDC(1), ECH1(1), ESCO1(7), ESCO2(3), FAH(1), GOT1(5), GOT2(1), GSTZ1(2), HGD(1), HPD(3), LCMT1(1), LCMT2(2), MAOA(2), METTL2B(1), METTL6(5), MYST3(13), MYST4(5), PNPLA3(4), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), SH3GLB1(3), TAT(3), TPO(8), TYR(2), TYRP1(2), WBSCR22(1) 12925962 145 49 144 56 58 37 3 40 7 0 0.408 1.000 1.000 491 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ACTR3(2), ARHGAP4(1), ARHGAP5(6), ARHGAP6(1), ARHGEF1(4), ARHGEF11(9), ARHGEF5(7), ARPC1A(5), ARPC1B(2), ARPC2(1), CFL1(1), DIAPH1(1), LIMK1(4), MYL2(1), MYLK(11), OPHN1(4), PIP5K1A(3), PIP5K1B(1), PPP1R12B(5), ROCK1(8), SRC(3), TLN1(5), VCL(1) 10197530 87 49 85 29 32 15 4 21 15 0 0.539 1.000 1.000 492 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 EGFR(10), GNAS(6), GNB1(1), GRB2(2), IGF1R(7), ITGB1(6), KLK2(3), MAP2K1(3), MAPK1(2), MAPK3(2), MKNK1(1), MKNK2(2), NGFR(2), PDGFRA(13), PPP2CA(1), PTPRR(1), RAF1(4), RPS6KA1(1), RPS6KA5(3), SHC1(3), SOS1(5), SRC(3), STAT3(2) 7497454 83 48 79 30 30 16 6 23 7 1 0.514 1.000 1.000 493 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 BCL2(1), CHUK(4), EGF(3), EGFR(10), ETS2(2), HOXA7(1), IKBKB(2), MAP2K1(3), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K5(5), MAPK1(2), MAPK14(3), MAPK3(2), MAPK8(2), NFKB1(3), PPP2CA(1), PRKCA(2), PRKCD(3), PRKCE(4), PRKCG(8), PRKCH(2), PRKCQ(4), RAF1(4), RELA(2), RIPK1(2), SP1(2), TNFRSF1A(1), TRAF2(1) 10848300 100 48 98 30 46 25 4 21 4 0 0.0661 1.000 1.000 494 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), CDS1(1), CDS2(4), CHAT(6), CHKA(2), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKI(6), DGKZ(2), ESCO1(7), ESCO2(3), ETNK1(2), ETNK2(1), GNPAT(1), GPAM(2), GPD1(1), GPD1L(2), GPD2(3), LCAT(1), MYST3(13), MYST4(5), PCYT1A(4), PCYT1B(5), PEMT(1), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLD1(8), PLD2(1), PNPLA3(4), PPAP2B(1), PTDSS1(4), SH3GLB1(3) 14912444 139 47 138 56 50 38 1 40 10 0 0.683 1.000 1.000 495 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(2), ARHGEF2(4), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTNNB1(8), EZR(2), FYN(4), HCLS1(7), ITGB1(6), KRT18(2), LY96(2), NCL(2), OCLN(1), PRKCA(2), RHOA(4), ROCK1(8), ROCK2(2), TLR4(7), TLR5(3), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WAS(1), WASL(5), YWHAQ(1) 11258995 121 47 120 44 44 24 2 38 13 0 0.371 1.000 1.000 496 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTB(2), ARHGEF2(4), ARPC5(1), ARPC5L(1), CD14(1), CDH1(4), CTNNB1(8), EZR(2), FYN(4), HCLS1(7), ITGB1(6), KRT18(2), LY96(2), NCL(2), OCLN(1), PRKCA(2), RHOA(4), ROCK1(8), ROCK2(2), TLR4(7), TLR5(3), TUBA3C(9), TUBA3D(2), TUBA3E(4), TUBA4A(1), TUBA8(1), TUBAL3(3), TUBB(1), TUBB1(2), TUBB2A(1), TUBB2B(3), TUBB3(1), TUBB4(2), TUBB4Q(2), TUBB6(3), TUBB8(2), WAS(1), WASL(5), YWHAQ(1) 11258995 121 47 120 44 44 24 2 38 13 0 0.371 1.000 1.000 497 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(8), AMY2A(3), ENPP1(4), ENPP3(3), G6PC(3), GANAB(4), GBA3(3), GBE1(4), GCK(1), GPI(1), GUSB(2), GYS1(1), GYS2(8), HK1(6), HK2(3), HK3(4), MGAM(9), PGM1(2), PGM3(4), PYGB(4), PYGL(2), PYGM(2), SI(12), UCHL1(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2), UXS1(6) 12220928 123 47 123 44 42 34 0 32 15 0 0.438 1.000 1.000 498 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 APAF1(7), BAD(1), BAX(1), BCL2(1), BCL2L1(1), BOK(1), CASP1(2), CASP10(2), CASP2(4), CASP3(1), CASP4(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CD40LG(6), CRADD(1), DFFA(2), DFFB(2), FASLG(1), IKBKE(3), NFKB1(3), NGFR(2), NR3C1(3), NTRK1(6), PTPN13(8), RIPK1(2), SFRS2IP(3), TFG(6), TNFRSF1A(1), TRADD(1), TRAF1(1), TRAF2(1), TRAF3(4), TRAF6(4) 9633096 97 46 95 40 28 19 5 29 15 1 0.796 1.000 1.000 499 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AADAT(1), AASDHPPT(2), AASS(7), ACAT1(1), ACAT2(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), BBOX1(1), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(2), EHMT2(1), GCDH(3), HADH(1), HADHA(2), HSD17B10(1), HSD17B4(3), HSD3B7(2), NSD1(11), OGDH(4), OGDHL(8), PIPOX(4), PLOD1(3), PLOD2(4), PLOD3(3), RDH12(2), RDH13(1), SETD1A(7), SETD7(2), SETDB1(7), SHMT1(1), SHMT2(2), SPCS1(1), SUV39H1(1), SUV39H2(2), TMLHE(1) 12998111 120 46 120 33 50 22 0 32 16 0 0.0678 1.000 1.000 500 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(5), ADRA1B(4), ADRA1D(2), ADRA2A(3), ADRB1(2), ADRB3(1), CHRM1(3), CHRM2(8), CHRM3(4), CHRM5(1), DRD1(1), DRD2(3), DRD3(3), DRD5(2), HRH1(1), HRH2(4), HTR1A(3), HTR1B(3), HTR1D(2), HTR1E(5), HTR1F(2), HTR2A(2), HTR2B(1), HTR2C(6), HTR4(2), HTR5A(2), HTR7(6) 5571446 81 46 81 31 37 22 1 12 9 0 0.296 1.000 1.000 501 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKM(1), PFKP(2), PGAM1(3), PGK1(3), PGM1(2), PGM3(4), PKM2(2), TPI1(1) 10721416 120 44 119 32 40 31 1 42 6 0 0.0341 1.000 1.000 502 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH9A1(1), ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHB(1), LDHC(2), PDHA1(4), PDHA2(6), PDHB(2), PFKM(1), PFKP(2), PGAM1(3), PGK1(3), PGM1(2), PGM3(4), PKM2(2), TPI1(1) 10721416 120 44 119 32 40 31 1 42 6 0 0.0341 1.000 1.000 503 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 APAF1(7), ARHGDIB(3), BAG4(2), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP2(4), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CFLAR(2), CHUK(4), CRADD(1), DFFA(2), DFFB(2), LMNB1(2), LMNB2(1), MAP3K1(6), MAP3K14(2), MAP3K5(5), MAPK8(2), MDM2(4), NFKB1(3), NUMA1(8), PAK2(2), PRKCD(3), PRKDC(13), PSEN1(3), PSEN2(2), PTK2(5), RASA1(5), RB1(4), RELA(2), RIPK1(2), SPTAN1(9), TNFRSF1A(1), TRADD(1), TRAF1(1), TRAF2(1) 15010091 136 43 135 44 41 36 6 35 16 2 0.329 1.000 1.000 504 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(5), ARHGEF11(9), BCL2(1), DLG4(2), GNA13(2), LPA(9), MAP2K4(9), MAP3K1(6), MAP3K5(5), MAPK8(2), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PHKA2(5), PIK3CB(2), PLD1(8), PLD2(1), PLD3(5), PTK2(5), RDX(2), ROCK1(8), ROCK2(2), SERPINA4(2), SRF(3) 10771387 103 43 102 34 42 20 2 27 12 0 0.400 1.000 1.000 505 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(2), ALOX12B(2), ALOX15B(5), ALOX5(4), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2J2(3), CYP2U1(1), CYP4A11(2), CYP4A22(2), CYP4F2(8), CYP4F3(2), EPHX2(1), GGT1(3), GPX1(1), GPX2(2), GPX3(1), GPX5(4), GPX6(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PTGIS(4), PTGS1(4), PTGS2(2), TBXAS1(5) 8677562 84 42 82 29 30 15 0 34 5 0 0.524 1.000 1.000 506 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3(1), CAD(10), CDA(1), CTPS(3), CTPS2(4), DCK(1), DCTD(3), DHODH(3), DPYD(8), DPYS(6), ENTPD1(2), ITPA(2), NT5E(2), NT5M(1), POLB(1), POLD1(5), POLD2(1), POLE(17), POLG(4), POLQ(8), POLR1B(6), POLR2A(6), POLR2B(5), POLR2D(1), POLR2E(1), POLR2H(1), POLR2I(1), POLRMT(1), RRM1(1), RRM2(2), TK1(1), TXNRD1(2), TYMS(2), UCK2(1), UNG(1), UPB1(3) 12821901 118 42 116 30 36 34 3 36 9 0 0.0268 1.000 1.000 507 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(14), ACACB(14), ACAT1(1), ACAT2(2), ACOT12(6), ACSS1(3), ACSS2(5), ACYP1(1), AKR1B1(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), DLAT(2), LDHA(1), LDHAL6A(2), LDHAL6B(1), LDHB(1), LDHC(2), LDHD(1), MDH1(1), MDH2(1), ME1(7), ME2(3), ME3(4), PC(3), PCK2(3), PDHA1(4), PDHA2(6), PDHB(2), PKM2(2) 10509085 114 41 114 31 42 27 1 30 14 0 0.0601 1.000 1.000 508 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(4), GTF2H4(1), GTF2IRD1(8), TAF1(7), TAF1L(16), TAF2(6), TAF4(4), TAF4B(4), TAF5(3), TAF5L(1), TAF6(2), TAF6L(2), TAF7(1), TAF7L(3), TAF9B(1), TBPL1(1), TBPL2(1) 7979127 78 41 78 21 30 17 1 24 6 0 0.201 1.000 1.000 509 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(3), CANX(2), CD4(2), CD74(1), CD8B(2), CIITA(6), CREB1(1), CTSB(2), CTSL1(3), CTSS(2), HLA-A(1), HLA-B(3), HLA-C(2), HLA-DMA(2), HLA-DOB(1), HLA-DPA1(1), HLA-DPB1(1), HLA-DQA1(1), HLA-DQA2(1), HLA-DRA(4), HLA-DRB1(1), HLA-E(1), HLA-F(1), HLA-G(1), HSP90AA1(2), HSP90AB1(1), IFI30(1), IFNA1(1), IFNA10(1), IFNA13(2), IFNA16(4), IFNA2(3), IFNA21(1), IFNA4(2), IFNA5(1), IFNA6(3), IFNA7(1), IFNA8(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(2), KIR3DL1(3), KIR3DL2(3), KIR3DL3(4), KLRC3(2), KLRC4(1), KLRD1(1), LGMN(1), NFYA(1), NFYB(1), NFYC(3), PDIA3(1), RFX5(1), RFXAP(1), TAP1(3), TAP2(4), TAPBP(3) 10215838 107 41 104 30 21 27 5 32 17 5 0.181 1.000 1.000 510 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(3), AKT1(2), BDKRB2(2), CHRM1(3), CHRNA1(2), FLT1(9), FLT4(4), KDR(8), NOS3(2), PDE3A(5), PDE3B(2), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKG1(4), PRKG2(3), RYR2(48), SLC7A1(2), SYT1(1), TNNI1(2) 8546463 109 41 109 44 39 26 4 30 10 0 0.583 1.000 1.000 511 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPS(2), CDS1(1), CDS2(4), CHAT(6), CHKA(2), CLC(2), CPT1B(5), DGKA(1), DGKB(7), DGKD(9), DGKE(1), DGKG(3), DGKH(5), DGKZ(2), ETNK1(2), GNPAT(1), GPD1(1), GPD2(3), LCAT(1), PAFAH1B1(3), PCYT1A(4), PCYT1B(5), PEMT(1), PLA2G1B(1), PLA2G4A(5), PLA2G6(2), PLCB2(3), PLCG1(4), PLCG2(9), PPAP2B(1) 11230533 106 40 104 41 40 25 1 29 11 0 0.600 1.000 1.000 512 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(2), ACADM(3), ACADSB(5), ACADVL(1), ACAT1(1), ACAT2(2), ACOX1(3), ACOX3(5), ACSL1(3), ACSL3(6), ACSL4(4), ACSL5(4), ACSL6(5), ADH1B(2), ADH1C(3), ADH4(1), ADH5(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH7A1(1), ALDH9A1(1), CPT1A(5), CPT1B(5), CPT2(1), CYP4A11(2), CYP4A22(2), ECHS1(2), EHHADH(2), GCDH(3), HADH(1), HADHA(2), HADHB(1), HSD17B10(1), HSD17B4(3), PECI(1) 10899520 115 40 115 32 34 29 3 38 11 0 0.0869 1.000 1.000 513 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(1), ALPP(1), ASCC3(14), ATP13A2(3), DDX18(2), DDX19A(2), DDX23(4), DDX4(2), DDX41(2), DDX47(3), DDX50(2), DDX52(1), DDX54(5), DDX55(2), DDX56(3), DHX58(2), ENTPD7(4), EP400(18), ERCC2(4), ERCC3(6), GGH(1), IFIH1(5), MOV10L1(6), RAD54B(6), RAD54L(3), RUVBL2(1), SETX(11), SKIV2L2(2), SMARCA2(8), SMARCA5(3) 14044387 129 40 126 38 54 35 3 24 12 1 0.0901 1.000 1.000 514 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 A4GALT(3), ABO(2), B3GALNT1(3), B3GALT1(1), B3GALT2(3), B3GALT4(1), B3GALT5(2), B3GNT1(2), B3GNT2(1), B3GNT4(1), B3GNT5(1), B4GALNT1(3), B4GALT1(5), B4GALT2(3), B4GALT3(6), B4GALT6(5), FUT1(1), FUT2(1), FUT3(3), FUT6(1), FUT9(4), GCNT2(9), PIGA(1), PIGB(1), PIGG(1), PIGK(3), PIGM(1), PIGN(1), PIGO(2), PIGQ(1), PIGS(2), PIGT(2), PIGX(2), ST3GAL1(1), ST3GAL2(1), ST3GAL3(4), ST3GAL4(2), ST3GAL6(4), ST6GALNAC3(3), ST6GALNAC4(1), ST6GALNAC5(4), ST6GALNAC6(3), ST8SIA1(3), ST8SIA5(4), UGCG(2) 10699097 110 40 110 30 45 21 4 23 17 0 0.0623 1.000 1.000 515 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(3), ACTR2(1), ACTR3(2), AKT1(2), ANGPTL2(8), CFL1(1), FLNA(2), FLNC(11), FSCN3(2), GDI1(1), GDI2(1), LIMK1(4), MYH2(9), MYLK(11), MYLK2(2), PAK1(4), PAK2(2), PAK3(3), PAK6(1), PAK7(4), PFN2(1), RHO(2), ROCK1(8), ROCK2(2), RPS4X(1), VASP(3), WASF1(1), WASL(5) 10426795 97 40 97 31 28 25 4 28 12 0 0.234 1.000 1.000 516 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(1), ADH1B(2), ADH1C(3), ADH4(1), ADH6(5), ADH7(2), ADHFE1(6), ALDH1A3(4), ALDH3A1(2), ALDH3B1(2), ALDH3B2(1), AOC2(4), AOC3(4), AOX1(5), DBH(4), DCT(9), DDC(1), FAH(1), GOT1(5), GOT2(1), GSTZ1(2), HGD(1), HPD(3), MAOA(2), TAT(3), TPO(8), TYR(2) 6853443 84 40 83 35 35 19 2 25 3 0 0.535 1.000 1.000 517 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(3), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CFLAR(2), DFFA(2), DFFB(2), FAF1(4), LMNB1(2), LMNB2(1), MAP2K4(9), MAP3K1(6), MAP3K7(2), MAPK8(2), PAK1(4), PAK2(2), PRKDC(13), PTPN13(8), RB1(4), RIPK2(3), SPTAN1(9) 8642205 94 39 92 28 19 27 3 27 15 3 0.338 1.000 1.000 518 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(4), CREB1(1), GNAI1(3), GNAQ(3), GNAS(6), GNB1(1), MAP2K1(3), MAPK3(2), NFATC1(1), NFATC2(3), NFATC3(4), NFATC4(4), PLCG1(4), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(4), RPS6KA3(3), SYT1(1) 7662745 64 39 63 23 30 9 3 14 8 0 0.363 1.000 1.000 519 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(3), ADCY3(1), ADCY9(4), ARF4(2), ARF6(1), ARL4D(1), ATP6V0A1(2), ATP6V0A2(2), ATP6V0A4(4), ATP6V0D1(2), ATP6V0D2(6), ATP6V1A(2), ATP6V1C1(2), ATP6V1C2(2), ATP6V1E1(1), ATP6V1E2(2), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(1), GNAS(6), PDIA4(4), PLCG1(4), PLCG2(9), PRKCA(2), SEC61A1(5), SEC61A2(1), SEC61B(1), TRIM23(5) 8245526 79 39 75 27 38 19 3 13 6 0 0.231 1.000 1.000 520 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(2), AKT2(5), DAG1(4), GNAQ(3), ITPKB(4), ITPR1(11), ITPR2(12), ITPR3(11), NFKB1(3), NFKB2(2), NFKBIB(1), NFKBIE(2), PHKA2(5), PIK3CB(2), PITX2(2), PLD1(8), PLD2(1), PLD3(5), VN1R1(4) 9571397 87 39 87 36 36 19 5 20 7 0 0.668 1.000 1.000 521 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(5), ACAA1(2), ACADM(3), ACAT1(1), ACAT2(2), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH6A1(3), ALDH7A1(1), ALDH9A1(1), AOX1(5), AUH(1), BCAT1(1), BCAT2(1), BCKDHA(3), BCKDHB(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(2), HADHB(1), HMGCS1(1), HSD17B10(1), HSD17B4(3), MCCC1(7), MCCC2(2), MCEE(1), MUT(3), OXCT1(3), OXCT2(1), PCCA(3), PCCB(3) 9779062 84 38 84 23 35 19 0 21 9 0 0.109 1.000 1.000 522 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(3), BAG4(2), CASP2(4), CASP3(1), CASP8(11), CRADD(1), DFFA(2), DFFB(2), LMNB1(2), LMNB2(1), MADD(13), MAP2K4(9), MAP3K1(6), MAP3K7(2), MAPK8(2), PAK1(4), PAK2(2), PRKDC(13), RB1(4), RIPK1(2), SPTAN1(9), TNFRSF1A(1), TRADD(1), TRAF2(1) 8374656 98 38 96 31 26 26 6 23 15 2 0.326 1.000 1.000 523 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(2), CDK2(2), DIAPH2(9), GMNN(1), MCM10(6), MCM3(1), MCM4(4), MCM5(3), MCM6(3), MCM7(2), NACA(5), ORC1L(1), ORC3L(1), ORC4L(1), ORC5L(1), PCNA(2), POLA2(2), POLD1(5), POLD2(1), POLD3(2), POLE(17), RFC1(10), RFC4(3), RFC5(2), RPA1(2), RPA2(1), RPA4(2), UBA52(2), UBB(1) 11215212 94 37 93 21 22 23 0 36 13 0 0.0538 1.000 1.000 524 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(1), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH3B1(2), ALDH3B2(1), ALDH7A1(1), ALDH9A1(1), AMDHD1(4), AOC2(4), AOC3(4), ASPA(3), CARM1(2), CNDP1(3), DDC(1), FTCD(2), HAL(3), HARS(2), HARS2(2), HDC(3), HNMT(4), LCMT1(1), LCMT2(2), MAOA(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), PRPS2(2), UROC1(1), WBSCR22(1) 8635576 86 37 86 30 32 26 0 23 5 0 0.291 1.000 1.000 525 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F11(4), F12(2), F13B(3), F2(2), F5(14), F7(2), F8(15), F9(6), FGA(11), FGB(1), FGG(4), LPA(9), PLAT(4), PLAU(2), PLG(7), SERPINB2(4), SERPINE1(1), VWF(10) 7829222 102 36 100 31 23 29 3 33 14 0 0.214 1.000 1.000 526 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(1), AGXT2(5), ALAS1(5), ALAS2(5), AOC2(4), AOC3(4), BHMT(3), CBS(2), CHDH(1), CHKA(2), CPT1B(5), CTH(1), DAO(2), DMGDH(5), GAMT(1), GARS(3), GATM(1), GLDC(2), MAOA(2), PEMT(1), PLCB2(3), PLCG1(4), PLCG2(9), SARDH(7), SARS(1), SHMT1(1), SHMT2(2), TARS(3) 9355479 85 36 84 30 38 22 0 14 11 0 0.385 1.000 1.000 527 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(5), ALDOC(1), DLAT(2), ENO2(3), ENO3(3), FBP2(2), G6PC(3), GCK(1), GOT1(5), GOT2(1), GPI(1), HK1(6), HK2(3), HK3(4), LDHA(1), LDHAL6B(1), LDHB(1), LDHC(2), MDH1(1), MDH2(1), PC(3), PDHA1(4), PDHA2(6), PDHB(2), PDHX(2), PFKL(1), PFKM(1), PFKP(2), PGAM1(3), PGAM2(1), PGK1(3), PGK2(6), PKM2(2), TNFAIP1(3), TPI1(1) 9310914 88 36 87 30 38 17 1 25 7 0 0.245 1.000 1.000 528 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(5), GABBR1(4), GPRC5A(2), GPRC5B(1), GPRC5C(1), GPRC5D(1), GRM1(9), GRM2(3), GRM3(5), GRM4(7), GRM5(8), GRM7(7), GRM8(7) 4584325 60 36 58 36 29 10 1 14 6 0 0.977 1.000 1.000 529 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(4), CREBBP(21), DUSP1(2), EP300(13), IKBKB(2), MAP2K3(2), MAP2K6(2), MAP3K14(2), MAP3K7(2), MAPK14(3), MYD88(1), NFKB1(3), NR3C1(3), RELA(2), TGFBR1(6), TGFBR2(7), TLR2(2) 6633479 77 36 76 27 26 20 4 18 9 0 0.472 1.000 1.000 530 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(1), ALDH1A1(3), ALDH1A2(6), ALDH1A3(4), ALDH1B1(5), ALDH2(3), ALDH3A1(2), ALDH3A2(4), ALDH4A1(2), ALDH9A1(1), AOC2(4), AOC3(4), ARG1(1), ARG2(4), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), DAO(2), GAMT(1), GATM(1), GLUD1(2), GOT1(5), GOT2(1), MAOA(2), NOS1(5), NOS3(2), ODC1(2), OTC(4), P4HA2(2), P4HA3(1), P4HB(2), RARS(2), SMS(2) 9734878 95 35 95 32 36 27 0 22 10 0 0.304 1.000 1.000 531 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 APAF1(7), BCL2(1), BID(1), BIRC2(2), BIRC3(2), CASP10(2), CASP3(1), CASP6(1), CASP7(1), CASP8(11), CASP9(2), CFLAR(2), CHUK(4), DFFA(2), DFFB(2), GAS2(2), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(2), SPTAN1(9), TNFRSF10A(3), TNFRSF10B(2), TNFSF10(1), TNFSF12(2), TRADD(1), TRAF2(1) 7482941 71 35 70 27 23 18 1 20 8 1 0.718 1.000 1.000 532 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT1(5), B4GALT2(3), FBP2(2), G6PC(3), GALE(1), GALK2(2), GALT(2), GANAB(4), GCK(1), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(4), LCT(15), MGAM(9), PFKM(1), PFKP(2), PGM1(2), PGM3(4) 7073837 78 35 78 28 34 22 1 19 2 0 0.295 1.000 1.000 533 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(1), AGXT2(5), ALAS1(5), ALAS2(5), AOC2(4), AOC3(4), BHMT(3), CBS(2), CHDH(1), CHKA(2), CTH(1), DAO(2), DMGDH(5), GAMT(1), GARS(3), GATM(1), GLDC(2), GNMT(1), HSD3B7(2), MAOA(2), PEMT(1), PHGDH(2), PIPOX(4), PSAT1(3), RDH12(2), RDH13(1), SARDH(7), SARS(1), SARS2(2), SDS(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(4) 9584384 87 35 87 31 35 22 0 19 11 0 0.397 1.000 1.000 534 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ACTA1(3), ADCY1(4), CCNB1(2), CDC25C(3), GNAI1(3), GNAS(6), GNB1(1), MAPK1(2), MAPK3(2), MYT1(8), PIN1(1), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), RPS6KA1(1), SRC(3) 4463740 46 35 46 17 18 12 2 12 2 0 0.485 1.000 1.000 535 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSA(1), ARSD(3), ARSE(2), ASAH1(3), B4GALT6(5), CERK(1), DEGS1(1), ENPP7(1), GALC(1), GLA(4), GLB1(3), LCT(15), NEU2(1), NEU3(1), PPAP2B(1), SGMS1(2), SGMS2(4), SGPP2(2), SMPD1(6), SMPD3(3), SMPD4(1), SPHK2(1), SPTLC1(4), SPTLC2(2), UGCG(2), UGT8(6) 7722581 76 34 75 26 25 23 2 21 5 0 0.234 1.000 1.000 536 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(5), POLA2(2), POLB(1), POLD1(5), POLD2(1), POLD3(2), POLE(17), POLE3(1), POLG(4), POLG2(1), POLH(4), POLI(7), POLK(2), POLM(1), POLQ(8), PRIM2(6), REV1(4), REV3L(15), RFC5(2) 9177018 88 34 86 25 23 24 0 30 10 1 0.220 1.000 1.000 537 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 ACTA1(3), CAPN1(2), CAPN2(5), CAPNS1(1), CAPNS2(1), EGF(3), EGFR(10), ITGA1(3), ITGB1(6), MAPK1(2), MAPK3(2), MYL2(1), MYLK(11), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PTK2(5), TLN1(5) 7199283 67 34 67 18 28 18 2 15 4 0 0.0688 1.000 1.000 538 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(4), IKBKB(2), IRAK1(1), LY96(2), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAP3K7(2), MAPK14(3), MAPK8(2), MYD88(1), NFKB1(3), PPARA(1), RELA(2), TIRAP(1), TLR10(1), TLR2(2), TLR3(4), TLR4(7), TLR6(2), TLR7(4), TLR9(4), TOLLIP(1), TRAF6(4) 7924876 75 34 74 26 27 14 5 21 8 0 0.408 1.000 1.000 539 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(1), EEF1G(1), EEF2(3), EIF2AK1(5), EIF2AK3(1), EIF2B1(2), EIF2B3(2), EIF2B5(5), EIF2S2(1), EIF2S3(1), EIF4A2(4), EIF4G1(8), EIF4G3(8), EIF5(3), EIF5A(1), EIF5B(4), ETF1(2), KIAA0664(4), PABPC1(3), PABPC3(4), PAIP1(1), SLC35A4(2) 9626724 66 34 65 19 21 15 2 18 10 0 0.216 1.000 1.000 540 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(3), ACTN2(7), ACTN3(2), CSK(1), CTNNA1(10), CTNNA2(10), CTNNB1(8), PECAM1(1), PTK2(5), SRC(3), VCL(1) 4146201 51 33 51 20 26 11 0 8 6 0 0.490 1.000 1.000 541 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), FPGT(3), FUK(1), GMDS(1), GMPPA(6), HK1(6), HK2(3), HK3(4), HSD3B7(2), KHK(1), LHPP(1), MPI(1), MTMR1(4), MTMR2(1), MTMR6(4), PFKFB1(6), PFKFB4(2), PFKL(1), PFKM(1), PFKP(2), PHPT1(1), PMM1(1), RDH12(2), RDH13(1), TPI1(1), TSTA3(1) 8359830 68 33 68 32 27 14 0 22 5 0 0.840 1.000 1.000 542 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), B4GALT1(5), B4GALT2(3), G6PC(3), GALE(1), GALK2(2), GALT(2), GANC(2), GCK(1), GLA(4), GLB1(3), HK1(6), HK2(3), HK3(4), HSD3B7(2), LCT(15), MGAM(9), PFKL(1), PFKM(1), PFKP(2), PGM1(2), PGM3(4), RDH12(2), RDH13(1), UGP2(5) 8426321 85 33 85 31 39 23 1 19 3 0 0.286 1.000 1.000 543 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(2), CASP3(1), CASP7(1), CASP8(11), INSR(5), ITCH(3), MAGI1(10), MAGI2(6), RERE(3), WWP1(5), WWP2(4) 5274070 54 33 53 19 16 12 1 15 10 0 0.551 1.000 1.000 544 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTA1(3), ACTN1(3), ACTN2(7), ACTN3(2), CAPN1(2), CAPNS1(1), CAPNS2(1), ITGA1(3), ITGB1(6), ITGB3(7), PTK2(5), SPTAN1(9), SRC(3), TLN1(5) 6160799 57 33 57 25 28 11 0 15 2 1 0.725 1.000 1.000 545 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(2), CDK7(1), ERCC3(6), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), MNAT1(1), POLR1A(7), POLR1B(6), POLR2A(6), POLR2B(5), POLR2E(1), POLR2H(1), POLR2I(1), POLR3B(5), POLR3D(3), POLR3E(3), POLR3H(1), TAF5(3), TAF6(2), TAF7(1), TBP(1) 7826739 65 32 65 22 23 22 1 14 5 0 0.424 1.000 1.000 546 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QB(1), C1R(2), C1S(3), C3(10), C5(9), C6(10), C7(2), C8A(3), C9(4), MASP1(9), MASP2(4) 4721445 57 31 57 22 17 11 2 18 8 1 0.610 1.000 1.000 547 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(5), ALDOC(1), FBP2(2), FPGT(3), GCK(1), GMDS(1), GMPPA(6), HK1(6), HK2(3), HK3(4), KHK(1), MPI(1), PFKFB1(6), PFKFB4(2), PFKM(1), PFKP(2), PMM1(1), TPI1(1) 5370479 50 31 50 22 19 11 0 17 3 0 0.737 1.000 1.000 548 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(2), EGF(3), EGFR(10), GRB2(2), MAP2K1(3), MAPK1(2), MAPK3(2), PTPRB(4), RAF1(4), RASA1(5), SHC1(3), SOS1(5), SPRY1(2), SPRY4(2), SRC(3) 5219520 52 31 50 19 17 15 4 12 4 0 0.561 1.000 1.000 549 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(2), ARG1(1), ARG2(4), ASS1(1), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), DAO(2), EPRS(9), GAMT(1), GATM(1), GLUD1(2), GLUD2(4), GOT1(5), GOT2(1), LAP3(1), NOS1(5), NOS3(2), OTC(4), P4HA2(2), P4HA3(1), RARS(2), RARS2(3) 7966782 68 30 68 25 22 19 0 16 11 0 0.570 1.000 1.000 550 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(1), ADRBK2(1), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CLCA1(4), CLCA2(4), CLCA4(5), CNGA3(5), CNGA4(5), CNGB1(7), GNAL(3), GUCA1A(1), GUCA1B(2), PDC(2), PDE1C(7), PRKACB(1), PRKACG(2), PRKG1(4), PRKG2(3), PRKX(2) 6841911 66 29 65 30 22 14 2 20 8 0 0.798 1.000 1.000 551 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCR1(5), CCR3(3), CCR5(1), CCR7(1), CD28(1), CD4(2), CXCR4(3), IFNG(1), IFNGR1(2), IFNGR2(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL18R1(8), IL2(3), IL4(3), IL4R(1), TGFB1(1), TGFB2(5) 4306926 50 29 51 27 13 17 0 15 5 0 0.901 1.000 1.000 552 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 DLG4(2), GRIN1(1), GRIN2A(15), GRIN2B(8), GRIN2C(2), GRIN2D(3), NOS1(5), PPP3CA(1), PPP3CB(4), PPP3CC(3), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(1) 5559468 54 29 54 31 25 12 1 9 7 0 0.896 1.000 1.000 553 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(1), CASP2(4), CHUK(4), CRADD(1), IKBKB(2), MAP2K3(2), MAP2K4(9), MAP2K6(2), MAP3K1(6), MAP3K14(2), MAPK14(3), MAPK8(2), NFKB1(3), RELA(2), RIPK1(2), TANK(3), TNFRSF1A(1), TRADD(1), TRAF2(1) 5336746 51 27 50 18 20 14 5 8 4 0 0.362 1.000 1.000 554 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 CHAT(6), DBH(4), DDC(1), GAD1(7), GAD2(4), HDC(3), MAOA(2), PAH(4), SLC18A3(6), TPH1(1) 3205276 38 26 38 18 16 10 1 10 1 0 0.660 1.000 1.000 555 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(4), GNAS(6), GNB1(1), PPP2CA(1), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAG2(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2) 3335731 32 26 32 16 12 6 2 9 3 0 0.919 1.000 1.000 556 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(1), AGPAT3(3), AGPAT4(6), AGPAT6(1), AGPS(2), ENPP2(10), ENPP6(1), PAFAH1B1(3), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), PLD1(8), PLD2(1), PPAP2B(1) 5305738 46 26 45 21 17 13 1 12 3 0 0.813 1.000 1.000 557 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 ALOX5(4), CYP1A2(2), CYP2C19(4), CYP2C8(2), CYP2C9(4), CYP2E1(5), CYP2J2(3), CYP3A4(1), CYP3A5(3), CYP3A7(4), HSD3B7(2), PLA2G1B(1), PLA2G2F(1), PLA2G4A(5), PLA2G6(2), RDH12(2), RDH13(1) 5381934 46 26 46 22 17 10 1 15 2 1 0.859 1.000 1.000 558 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 CSNK2A1(4), GRB2(2), IL2(3), IL2RA(2), IL2RB(1), JAK1(3), JAK3(6), LCK(2), MAP2K1(3), MAPK3(2), MAPK8(2), RAF1(4), SHC1(3), SOS1(5), STAT5B(2) 5202226 44 26 41 16 14 11 4 12 3 0 0.451 1.000 1.000 559 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(6), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(2), NCOA1(6), NCOA2(4), NCOA3(6), NCOR2(2), POLR2A(6), RXRA(1), TBP(1) 5475968 45 26 45 17 15 15 2 11 2 0 0.514 1.000 1.000 560 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), CSF1R(3), EGF(3), EGFR(10), GRB2(2), MET(4), PDGFRA(13), PRKCA(2), SH3GLB1(3), SH3GLB2(2), SH3KBP1(4), SRC(3) 4356169 51 25 51 25 14 12 3 17 4 1 0.902 1.000 1.000 561 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA1(1), CA13(1), CA14(2), CA2(1), CA3(1), CA4(1), CA5A(1), CA6(2), CA8(2), CA9(2), CPS1(8), CTH(1), GLS2(2), GLUD1(2), GLUD2(4), GLUL(3), HAL(3) 4723117 38 25 38 20 16 10 0 5 7 0 0.917 1.000 1.000 562 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(2), BLVRB(1), CP(3), EPRS(9), FECH(2), GUSB(2), HCCS(1), HMBS(2), HMOX1(2), HMOX2(1), PPOX(3), UGT1A1(1), UGT1A10(1), UGT1A3(2), UGT1A4(1), UGT1A5(3), UGT1A7(2), UGT1A9(5), UGT2B15(2), UGT2B4(2), UROS(1) 5985307 48 25 47 16 17 12 0 14 5 0 0.542 1.000 1.000 563 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 APAF1(7), BIRC2(2), BIRC3(2), CASP10(2), CASP3(1), CASP7(1), CASP8(11), CASP9(2), DFFA(2), DFFB(2), GZMB(1), SCAP(1), SREBF1(1), SREBF2(2) 4114605 37 25 36 14 6 9 2 12 8 0 0.739 1.000 1.000 564 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3D(1), CD3G(2), ETV5(5), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(5), IL18R1(8), JAK2(6), MAP2K6(2), MAPK14(3), MAPK8(2), TYK2(1) 4057783 41 24 42 20 9 15 1 9 6 1 0.860 1.000 1.000 565 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), IL6R(2), JAK1(3), JAK2(6), JAK3(6), PIAS3(4), PTPRU(6), REG1A(3), SRC(3), STAT3(2) 3414083 36 24 34 16 17 10 1 4 3 1 0.666 1.000 1.000 566 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(4), CFTR(8), GNAS(6), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(3) 2819035 28 23 28 10 10 4 1 10 3 0 0.560 1.000 1.000 567 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(14), CPT1A(5), LEP(1), LEPR(5), PRKAA1(2), PRKAA2(6), PRKAB1(1), PRKAB2(1), PRKAG1(1), PRKAG2(2) 3291336 38 23 38 13 13 8 0 12 5 0 0.672 1.000 1.000 568 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(4), DYRK1B(4), GLI2(2), GLI3(9), GSK3B(7), PRKACB(1), PRKACG(2), PRKAR1A(1), PRKAR1B(1), PRKAR2B(2), SUFU(4) 3605755 37 23 37 21 18 9 2 3 5 0 0.807 1.000 1.000 569 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CMAS(5), CYB5R3(1), GCK(1), GFPT1(3), GNE(2), GNPDA2(1), HEXB(1), HK1(6), HK2(3), HK3(4), PGM3(4), RENBP(1) 3839585 32 22 32 12 11 9 0 11 1 0 0.619 1.000 1.000 570 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(5), CD2(3), CD33(1), CD5(2), CD7(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12B(2), IL13(1), IL3(3), IL4(3), ITGAX(4), TLR2(2), TLR4(7), TLR7(4), TLR9(4) 4079295 46 22 45 19 18 7 4 15 2 0 0.651 1.000 1.000 571 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMC2(1), PSMC3(3), PSMD1(4), PSMD11(3), PSMD12(2), PSMD13(1), PSMD2(3), PSMD6(2) 3656759 32 22 32 15 10 7 2 10 3 0 0.865 1.000 1.000 572 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(7), AP2A1(2), AP2M1(4), BIN1(1), DNM1(8), EPN1(1), EPS15(4), PICALM(2), PPP3CA(1), PPP3CB(4), PPP3CC(3), SYNJ1(8), SYNJ2(5), SYT1(1) 4935230 51 22 49 22 14 11 1 13 12 0 0.759 1.000 1.000 573 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), ESRRA(2), HDAC5(1), MEF2A(3), MEF2C(7), MEF2D(1), PPARA(1), PPP3CA(1), PPP3CB(4), PPP3CC(3), SLC2A4(3), SYT1(1) 4445983 40 22 40 22 16 9 2 8 5 0 0.902 1.000 1.000 574 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(3), JAK2(6), JAK3(6), PIAS1(3), PIAS3(4), PTPRU(6), REG1A(3), SOAT1(1) 2999033 32 22 30 11 15 7 1 3 5 1 0.431 1.000 1.000 575 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(6), KHK(1), LCT(15), MPI(1), PGM1(2), PYGL(2), PYGM(2), TPI1(1), TREH(2) 2940178 32 21 32 13 10 10 1 11 0 0 0.560 1.000 1.000 576 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(4), ASPH(2), CREB1(1), EDN1(1), EP300(13), HIF1A(1), LDHA(1), NOS3(2), P4HB(2) 3773095 27 21 27 10 8 11 0 6 2 0 0.583 1.000 1.000 577 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PCYT1A(4), PCYT1B(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), WBSCR22(1) 3044783 31 21 31 14 9 9 0 11 2 0 0.791 1.000 1.000 578 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 RPL10A(1), RPL10L(2), RPL18A(1), RPL21(1), RPL22L1(1), RPL24(1), RPL28(1), RPL3(2), RPL31(2), RPL32(1), RPL35(1), RPL39(1), RPL3L(1), RPL6(1), RPL7(1), RPL9(3), RPS11(1), RPS13(1), RPS16(1), RPS18(1), RPS20(1), RPS23(4), RPS3(1), RPS9(2), RPSA(1) 4704872 34 21 34 10 14 7 0 10 3 0 0.550 1.000 1.000 579 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), CSF1(1), HLA-DRA(4), HLA-DRB1(1), IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL11(1), IL12B(2), IL13(1), IL15(1), IL1A(1), IL2(3), IL3(3), IL4(3), IL6(1), IL7(1), PDGFA(1), TGFB1(1), TGFB2(5) 2962589 36 21 35 17 15 5 0 11 3 2 0.854 1.000 1.000 580 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(4), IKBKB(2), IL1A(1), IL1R1(3), IRAK1(1), MAP3K1(6), MAP3K14(2), MAP3K7(2), MYD88(1), NFKB1(3), RELA(2), RIPK1(2), TLR4(7), TNFAIP3(2), TNFRSF1A(1), TRADD(1), TRAF6(4) 5352135 44 21 44 15 18 7 2 12 5 0 0.512 1.000 1.000 581 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(6), GBA3(3), LPO(2), MPO(3), PRDX6(2), TPO(8), TYR(2) 2084474 26 21 25 11 13 3 0 6 4 0 0.665 1.000 1.000 582 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(4), DUSP1(2), IKBKAP(2), IKBKB(2), MAP3K1(6), MAP3K14(2), NFKB1(3), RELA(2), RIPK1(2), TANK(3), TNFAIP3(2), TRAF1(1), TRAF2(1), TRAF3(4) 4909107 36 21 36 13 19 6 0 7 4 0 0.529 1.000 1.000 583 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(5), ARG1(1), ARG2(4), CKM(4), CKMT1B(1), CKMT2(2), CPS1(8), GAMT(1), GATM(1), GLUD1(2), ODC1(2), OTC(4), SMS(2) 3871111 39 21 39 14 11 12 0 9 7 0 0.543 1.000 1.000 584 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(6), CHKA(2), PCYT1A(4), PDHA1(4), PDHA2(6), PEMT(1), SLC18A3(6) 1541377 29 20 29 13 11 10 0 6 2 0 0.577 1.000 1.000 585 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(1), ARFGAP3(3), ARFGEF2(5), CLTA(1), COPA(1), GBF1(11), GPLD1(4), KDELR1(2), KDELR3(1) 3698530 29 20 29 12 12 7 0 8 2 0 0.697 1.000 1.000 586 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(4), DUSP1(2), IKBKAP(2), IKBKB(2), MAP3K1(6), MAP3K14(2), NFKB1(3), RELA(2), TNFAIP3(2), TRAF3(4), TRAF6(4) 3958494 33 20 33 13 17 3 0 8 5 0 0.753 1.000 1.000 587 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1(1), CSF1R(3), DDX20(3), E2F4(1), ETS2(2), HDAC2(2), HDAC5(1), NCOR2(2), RBL1(3), RBL2(8), SIN3A(4), SIN3B(3) 5838416 33 20 33 18 10 6 0 9 8 0 0.937 1.000 1.000 588 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(6), GBA3(3), LPO(2), MPO(3), PRDX6(2), TPO(8) 1804099 24 20 23 10 13 3 0 4 4 0 0.647 1.000 1.000 589 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(1), IL22(2), IL22RA1(1), JAK1(3), JAK2(6), JAK3(6), STAT1(6), STAT3(2), STAT5B(2), TYK2(1) 4105561 30 20 29 14 12 6 2 7 2 1 0.748 1.000 1.000 590 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA1(1), CA14(2), CA2(1), CA3(1), CA4(1), CA5A(1), CA6(2), CA8(2), CA9(2), CPS1(8), CTH(1), GLS2(2), GLUD1(2), GLUL(3), HAL(3) 4228309 33 20 33 18 13 9 0 5 6 0 0.932 1.000 1.000 591 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(1), IFNB1(1), IFNG(1), IL10(1), IL12B(2), IL13(1), IL15(1), IL16(5), IL1A(1), IL2(3), IL3(3), IL4(3), IL6(1), IL9(1) 2161600 25 19 24 15 11 3 1 9 1 0 0.931 1.000 1.000 592 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(5), GPI(1), HK1(6), PFKL(1), PGAM1(3), PGK1(3), TPI1(1) 1973401 20 19 19 10 9 1 0 10 0 0 0.839 1.000 1.000 593 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(1), HK1(6), HK2(3), HK3(4), IMPA1(2), IMPA2(2), PGM1(2), PGM3(4) 2602494 24 18 24 11 7 6 0 10 1 0 0.764 1.000 1.000 594 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(3), GPLD1(4), PGAP1(6), PIGA(1), PIGB(1), PIGG(1), PIGK(3), PIGM(1), PIGN(1), PIGO(2), PIGQ(1), PIGS(2), PIGT(2), PIGW(1), PIGX(2) 5295934 31 18 31 13 10 6 1 9 5 0 0.754 1.000 1.000 595 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(2), ACP2(2), ACP5(1), ACPP(3), ENPP1(4), ENPP3(3), FLAD1(1), LHPP(1), MTMR1(4), MTMR2(1), MTMR6(4), PHPT1(1), TYR(2) 3392154 29 18 28 13 10 7 1 8 3 0 0.764 1.000 1.000 596 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 17 CARM1(2), DHRS1(1), DHRS2(2), DHRS3(2), LCMT1(1), LCMT2(2), METTL2B(1), METTL6(5), PRMT2(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(2), PRMT8(3), WBSCR22(1) 3086940 27 17 27 12 9 6 0 8 4 0 0.767 1.000 1.000 597 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), BLVRB(1), HMOX1(2), IL10(1), IL10RA(1), IL10RB(4), IL1A(1), IL6(1), JAK1(3), STAT1(6), STAT3(2) 2695158 24 16 22 16 10 4 1 8 1 0 0.946 1.000 1.000 598 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), CD38(1), ENPP1(4), ENPP3(3), NADSYN1(2), NMNAT1(1), NMNAT2(1), NNMT(1), NNT(1), NT5E(2), NT5M(1), QPRT(1) 3342830 23 16 23 11 9 8 0 4 2 0 0.663 1.000 1.000 599 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(5), CKM(4), FBL(3), LDHA(1), LDHB(1), LDHC(2), MAPK14(3), NCL(2) 2001413 21 16 21 10 9 4 1 6 1 0 0.756 1.000 1.000 600 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(1), HK1(6), HK2(3), HK3(4), IMPA1(2), PGM1(2), PGM3(4) 2292278 22 16 22 11 6 6 0 10 0 0 0.825 1.000 1.000 601 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 17 B3GAT1(1), CHPF(3), CHST11(2), CHST12(2), CHST13(1), CHST14(1), CHSY1(5), DSE(2), UST(1), XYLT1(4), XYLT2(2) 3112850 24 15 24 21 8 7 2 5 2 0 0.995 1.000 1.000 602 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(3), APAF1(7), BCL2(1), CASP3(1), CASP9(2), FASLG(1), HSPB2(1), IL1A(1), MAPKAPK2(3), MAPKAPK3(1) 2523475 21 15 21 10 6 6 0 6 3 0 0.829 1.000 1.000 603 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(3), CD3D(1), CD3G(2), CD4(2), IFNG(1), IL12B(2), IL12RB1(2), IL12RB2(5), JAK2(6), TYK2(1) 3208183 26 15 27 17 5 10 1 6 3 1 0.977 1.000 1.000 604 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(1), PSMA2(1), PSMA3(2), PSMA4(2), PSMA5(1), PSMB2(2), PSMB5(2), PSMB6(2), PSMC3(3), UBE2A(2), UBE3A(6) 2912778 24 15 24 11 8 5 2 6 3 0 0.744 1.000 1.000 605 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CAMK1(1), CAMK1G(3), CAMK2A(1), CAMK2B(2), CAMK2D(2), CAMK2G(2), CAMK4(2), CAMKK1(1), CAMKK2(1), CREB1(1), SYT1(1) 2635776 17 13 17 12 6 5 2 3 1 0 0.958 1.000 1.000 606 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(3), HDAC9(11), MEF2A(3), MEF2C(7), MEF2D(1) 1540933 26 13 26 12 8 7 0 11 0 0 0.772 1.000 1.000 607 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(4), MBTPS1(5), SCAP(1), SREBF1(1), SREBF2(2) 2699442 14 13 14 10 4 6 1 0 3 0 0.922 1.000 1.000 608 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(3), CSF1(1), IL6R(2), SPN(1), TGFB1(1), TGFB2(5), TNFRSF1A(1), TNFRSF8(1), TNFSF8(1) 2984627 18 13 18 10 5 4 1 4 4 0 0.914 1.000 1.000 609 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(4), GNAS(6), GNB1(1), PRKAR1A(1) 1418552 12 12 12 8 5 3 1 3 0 0 0.930 1.000 1.000 610 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(6), GNA12(2), PRKACB(1), PRKACG(2), PRKAG1(1), PRKAR2B(2) 2291654 14 11 14 10 4 3 0 2 5 0 0.975 1.000 1.000 611 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST2(1), HS3ST3B1(2), XYLT1(4), XYLT2(2) 1408533 10 9 10 12 4 1 1 3 1 0 0.998 1.000 1.000 612 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(4), NR1H3(4), NR1H4(1), RXRA(1) 1180979 11 9 11 7 4 6 0 1 0 0 0.815 1.000 1.000 613 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(1), HS3ST2(1), HS3ST3B1(2), XYLT1(4), XYLT2(2) 1408533 10 9 10 12 4 1 1 3 1 0 0.998 1.000 1.000 614 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS2(2), GLUD1(2), GLUD2(4) 955348 8 8 8 5 6 1 0 1 0 0 0.866 1.000 1.000 615 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(1), IL12B(2), IL2(3) 661707 8 6 8 5 0 3 0 5 0 0 0.936 1.000 1.000 616 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 116383 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000