Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.02 0.139 -9999.0 0.0 -0.599 19.0 19.0 IHH 0.005 0.086 -9999.0 0.0 -0.492 12.0 12.0 SHH Np/Cholesterol/GAS1 -0.094 0.199 -9999.0 0.0 -0.477 82.0 82.0 LRPAP1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.093 0.197 0.473 82.0 -9999.0 0.0 82.0 SMO/beta Arrestin2 0.016 0.096 -9999.0 0.0 -0.511 6.0 6.0 SMO 0.01 0.1 -9999.0 0.0 -0.542 6.0 6.0 AKT1 0.025 0.049 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.003 0.063 -9999.0 0.0 -0.435 9.0 9.0 ADRBK1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.01 0.099 -9999.0 0.0 -0.533 6.0 6.0 STIL -0.039 0.167 -9999.0 0.0 -0.372 80.0 80.0 DHH N/PTCH2 0.003 0.07 -9999.0 0.0 -0.313 20.0 20.0 DHH N/PTCH1 0.014 0.099 -9999.0 0.0 -0.52 6.0 6.0 PIK3CA 0.012 0.001 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.008 0.091 -9999.0 0.0 -0.435 19.0 19.0 PTHLH 0.018 0.156 -9999.0 0.0 -0.638 19.0 19.0 determination of left/right symmetry 0.01 0.099 -9999.0 0.0 -0.533 6.0 6.0 PIK3R1 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.018 0.154 -9999.0 0.0 -0.63 19.0 19.0 IHH N/Hhip -0.062 0.157 -9999.0 0.0 -0.346 98.0 98.0 DHH N/Hhip -0.064 0.151 -9999.0 0.0 -0.326 105.0 105.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.01 0.099 -9999.0 0.0 -0.533 6.0 6.0 pancreas development -0.085 0.184 -9999.0 0.0 -0.435 96.0 96.0 HHAT 0.008 0.042 -9999.0 0.0 -0.435 4.0 4.0 PI3K 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.051 0.162 -9999.0 0.0 -0.455 60.0 60.0 somite specification 0.01 0.099 -9999.0 0.0 -0.533 6.0 6.0 SHH Np/Cholesterol/PTCH1 -0.046 0.175 -9999.0 0.0 -0.394 82.0 82.0 SHH Np/Cholesterol/PTCH2 -0.061 0.174 -9999.0 0.0 -0.435 78.0 78.0 SHH Np/Cholesterol/Megalin -0.102 0.214 -9999.0 0.0 -0.468 107.0 107.0 SHH -0.083 0.218 -9999.0 0.0 -0.541 81.0 81.0 catabolic process 0.021 0.092 -9999.0 0.0 -0.547 5.0 5.0 SMO/Vitamin D3 -0.036 0.169 -9999.0 0.0 -0.475 13.0 13.0 SHH Np/Cholesterol/Hhip -0.112 0.189 -9999.0 0.0 -0.457 80.0 80.0 LRP2 -0.057 0.207 -9999.0 0.0 -0.731 38.0 38.0 receptor-mediated endocytosis -0.05 0.176 -9999.0 0.0 -0.544 18.0 18.0 SHH Np/Cholesterol/BOC -0.065 0.177 -9999.0 0.0 -0.441 77.0 77.0 SHH Np/Cholesterol/CDO -0.06 0.174 -9999.0 0.0 -0.435 77.0 77.0 mesenchymal cell differentiation 0.112 0.187 0.454 80.0 -9999.0 0.0 80.0 mol:Vitamin D3 -0.044 0.176 -9999.0 0.0 -0.392 82.0 82.0 IHH N/PTCH2 0.013 0.06 -9999.0 0.0 -0.394 5.0 5.0 CDON 0.012 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.023 0.093 -9999.0 0.0 -0.552 5.0 5.0 Megalin/LRPAP1 -0.035 0.158 -9999.0 0.0 -0.552 38.0 38.0 PTCH2 0.01 0.035 -9999.0 0.0 -0.731 1.0 1.0 SHH Np/Cholesterol -0.068 0.173 -9999.0 0.0 -0.431 81.0 81.0 PTCH1 0.021 0.092 -9999.0 0.0 -0.549 5.0 5.0 HHIP -0.085 0.184 -9999.0 0.0 -0.435 96.0 96.0