E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.022 0.036 -9999.0 0.0 -0.306 3.0 3.0 KLHL20 0.043 0.073 0.206 26.0 -0.228 6.0 32.0 CYFIP2 0.026 0.021 -9999.0 0.0 -0.393 1.0 1.0 Rac1/GDP 0.07 0.08 0.277 5.0 -9999.0 0.0 5.0 ENAH 0.022 0.036 -9999.0 0.0 -0.306 3.0 3.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.019 0.022 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.007 0.027 -9999.0 0.0 -0.157 6.0 6.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.055 -9999.0 0.0 -0.213 6.0 6.0 RAPGEF1 0.056 0.081 0.301 5.0 -0.281 1.0 6.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.03 0.037 -9999.0 0.0 -0.288 5.0 5.0 CRK 0.056 0.076 -9999.0 0.0 -0.299 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.053 0.018 -9999.0 0.0 -0.234 1.0 1.0 alphaE/beta7 Integrin 0.023 0.06 -9999.0 0.0 -0.263 17.0 17.0 IQGAP1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.05 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.022 0.037 -9999.0 0.0 -0.306 3.0 3.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.005 0.01 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.02 0.086 -9999.0 0.0 -0.23 42.0 42.0 PI3K 0.009 0.014 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.025 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.039 0.017 -9999.0 0.0 -0.277 1.0 1.0 TIAM1 -0.011 0.12 -9999.0 0.0 -0.393 39.0 39.0 E-cadherin(dimer)/Ca2+ 0.063 0.014 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 0.032 0.041 0.142 1.0 -9999.0 0.0 1.0 PIK3R1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GDP 0.082 0.08 0.273 6.0 -9999.0 0.0 6.0 actin cytoskeleton organization 0.04 0.06 0.173 28.0 -0.166 6.0 34.0 CDC42/GDP 0.076 0.08 0.265 5.0 -9999.0 0.0 5.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.02 0.012 -9999.0 0.0 -0.203 1.0 1.0 ITGB7 0.011 0.082 -9999.0 0.0 -0.393 17.0 17.0 RAC1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.068 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.048 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.073 0.087 0.279 6.0 -0.286 1.0 7.0 CDC42/GTP/IQGAP1 0.033 0.017 -9999.0 0.0 -0.232 1.0 1.0 JUP 0.026 0.021 -9999.0 0.0 -0.393 1.0 1.0 p120 catenin/RhoA/GDP 0.09 0.08 0.283 5.0 -9999.0 0.0 5.0 RAC1/GTP/IQGAP1 0.032 0.013 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.016 -9999.0 0.0 -0.277 1.0 1.0 RHOA 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.025 0.021 -9999.0 0.0 -0.393 1.0 1.0 CTNNA1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.032 0.046 0.136 29.0 -0.164 3.0 32.0 NME1 0.018 0.066 0.362 1.0 -0.424 9.0 10.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.021 0.036 -9999.0 0.0 -0.306 3.0 3.0 regulation of cell-cell adhesion 0.013 0.016 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.015 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.081 0.071 0.29 4.0 -9999.0 0.0 4.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.058 0.058 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.036 0.053 0.152 28.0 -0.202 3.0 31.0 VAV2 0.073 0.132 -9999.0 0.0 -0.618 9.0 9.0 RAP1/GDP 0.088 0.078 0.282 6.0 -9999.0 0.0 6.0 adherens junction assembly 0.021 0.035 -9999.0 0.0 -0.297 3.0 3.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.026 0.02 -9999.0 0.0 -0.393 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.044 0.051 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin 0.013 0.011 -9999.0 0.0 -0.152 1.0 1.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.014 0.031 -9999.0 0.0 -0.307 2.0 2.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.003 0.063 -9999.0 0.0 -0.348 8.0 8.0 E-cadherin/beta catenin/alpha catenin 0.054 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ITGAE 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.03 0.038 -9999.0 0.0 -0.293 5.0 5.0