Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.03 0.058 0.299 12.0 -0.238 1.0 13.0 KIRREL 0.023 0.043 -9999.0 0.0 -0.401 4.0 4.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.03 0.058 0.239 1.0 -0.299 12.0 13.0 PLCG1 0.017 0.013 -9999.0 0.0 -9999.0 0.0 0.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.044 0.074 0.231 1.0 -0.232 27.0 28.0 ChemicalAbstracts:57-88-5 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP 0.021 0.032 0.161 1.0 -0.206 5.0 6.0 FYN 0.013 0.059 0.272 10.0 -0.2 14.0 24.0 mol:Ca2+ 0.029 0.054 -9999.0 0.0 -0.23 11.0 11.0 mol:DAG 0.03 0.054 -9999.0 0.0 -0.231 11.0 11.0 NPHS2 0.014 0.046 -9999.0 0.0 -0.421 4.0 4.0 mol:IP3 0.03 0.054 -9999.0 0.0 -0.231 11.0 11.0 regulation of endocytosis 0.037 0.048 0.212 1.0 -0.239 3.0 4.0 Nephrin/NEPH1/podocin/Cholesterol 0.037 0.052 0.213 1.0 -0.226 14.0 15.0 establishment of cell polarity 0.03 0.058 0.238 1.0 -0.299 12.0 13.0 Nephrin/NEPH1/podocin/NCK1-2 0.066 0.056 -9999.0 0.0 -0.378 1.0 1.0 Nephrin/NEPH1/beta Arrestin2 0.039 0.049 0.219 1.0 -0.241 3.0 4.0 NPHS1 0.016 0.065 0.33 1.0 -0.427 8.0 9.0 Nephrin/NEPH1/podocin 0.039 0.047 0.216 1.0 -0.201 14.0 15.0 TJP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 NCK1 0.027 0.002 -9999.0 0.0 -9999.0 0.0 0.0 NCK2 0.027 0.001 -9999.0 0.0 -9999.0 0.0 0.0 heterophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.031 0.055 -9999.0 0.0 -0.232 11.0 11.0 CD2AP 0.015 0.072 -9999.0 0.0 -0.393 13.0 13.0 Nephrin/NEPH1/podocin/GRB2 0.052 0.056 0.231 1.0 -0.23 13.0 14.0 GRB2 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.011 0.076 0.281 8.0 -0.236 21.0 29.0 cytoskeleton organization 0.011 0.041 0.197 5.0 -0.277 1.0 6.0 Nephrin/NEPH1 0.026 0.041 0.195 1.0 -0.203 12.0 13.0 Nephrin/NEPH1/ZO-1 0.041 0.05 0.226 1.0 -0.231 12.0 13.0