Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.014 0.097 -9999.0 0.0 -0.485 8.0 8.0 IHH 0.019 0.083 -9999.0 0.0 -0.448 12.0 12.0 SHH Np/Cholesterol/GAS1 -0.046 0.126 0.187 1.0 -0.248 114.0 115.0 LRPAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.046 0.125 0.246 114.0 -0.185 1.0 115.0 SMO/beta Arrestin2 0.019 0.089 -9999.0 0.0 -0.483 5.0 5.0 SMO 0.007 0.083 -9999.0 0.0 -0.504 5.0 5.0 AKT1 0.001 0.109 -9999.0 0.0 -0.402 13.0 13.0 ARRB2 0.023 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.018 0.06 -9999.0 0.0 -0.393 9.0 9.0 ADRBK1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.008 0.083 -9999.0 0.0 -0.496 5.0 5.0 STIL -0.016 0.107 -9999.0 0.0 -0.364 7.0 7.0 DHH N/PTCH2 0.024 0.067 -9999.0 0.0 -0.277 20.0 20.0 DHH N/PTCH1 0.021 0.09 -9999.0 0.0 -0.455 6.0 6.0 PIK3CA 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.006 0.086 -9999.0 0.0 -0.393 19.0 19.0 PTHLH 0.009 0.122 -9999.0 0.0 -0.727 8.0 8.0 determination of left/right symmetry 0.008 0.083 -9999.0 0.0 -0.496 5.0 5.0 PIK3R1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.009 0.12 -9999.0 0.0 -0.72 8.0 8.0 IHH N/Hhip -0.039 0.151 -9999.0 0.0 -0.314 98.0 98.0 DHH N/Hhip -0.04 0.147 -9999.0 0.0 -0.301 100.0 100.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.008 0.083 -9999.0 0.0 -0.496 5.0 5.0 pancreas development -0.063 0.17 -9999.0 0.0 -0.393 91.0 91.0 HHAT 0.023 0.04 -9999.0 0.0 -0.393 4.0 4.0 PI3K 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.029 0.144 -9999.0 0.0 -0.395 58.0 58.0 somite specification 0.008 0.083 -9999.0 0.0 -0.496 5.0 5.0 SHH Np/Cholesterol/PTCH1 -0.017 0.105 -9999.0 0.0 -0.358 9.0 9.0 SHH Np/Cholesterol/PTCH2 -0.019 0.099 0.187 3.0 -0.228 78.0 81.0 SHH Np/Cholesterol/Megalin -0.041 0.12 0.18 3.0 -0.247 105.0 108.0 SHH -0.04 0.122 0.274 3.0 -0.301 76.0 79.0 catabolic process 0.019 0.076 -9999.0 0.0 -0.415 7.0 7.0 SMO/Vitamin D3 -0.013 0.107 -9999.0 0.0 -0.434 6.0 6.0 SHH Np/Cholesterol/Hhip -0.062 0.127 0.185 3.0 -0.233 149.0 152.0 LRP2 -0.032 0.123 -9999.0 0.0 -0.424 38.0 38.0 receptor-mediated endocytosis -0.026 0.108 -9999.0 0.0 -0.421 9.0 9.0 SHH Np/Cholesterol/BOC -0.022 0.102 0.187 2.0 -0.23 82.0 84.0 SHH Np/Cholesterol/CDO -0.018 0.098 0.187 2.0 -0.228 77.0 79.0 mesenchymal cell differentiation 0.062 0.127 0.231 149.0 -0.183 3.0 152.0 mol:Vitamin D3 -0.01 0.114 -9999.0 0.0 -0.359 9.0 9.0 IHH N/PTCH2 0.031 0.056 -9999.0 0.0 -0.27 13.0 13.0 CDON 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.027 0.079 -9999.0 0.0 -0.418 7.0 7.0 Megalin/LRPAP1 0.006 0.096 -9999.0 0.0 -0.302 38.0 38.0 PTCH2 0.025 0.022 -9999.0 0.0 -0.424 1.0 1.0 SHH Np/Cholesterol -0.028 0.092 -9999.0 0.0 -0.227 77.0 77.0 PTCH1 0.019 0.076 -9999.0 0.0 -0.416 7.0 7.0 HHIP -0.063 0.171 -9999.0 0.0 -0.393 91.0 91.0