E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.017 0.089 -9999.0 0.0 -0.433 5.0 5.0 KLHL20 0.044 0.094 0.227 9.0 -0.234 2.0 11.0 CYFIP2 0.021 0.078 -9999.0 0.0 -0.514 3.0 3.0 Rac1/GDP 0.075 0.096 0.323 2.0 -0.281 2.0 4.0 ENAH 0.016 0.089 -9999.0 0.0 -0.433 5.0 5.0 AP1M1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.029 0.029 -9999.0 0.0 -0.321 1.0 1.0 CDC42/GTP 0.018 0.043 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.016 0.038 -9999.0 0.0 -0.182 4.0 4.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.034 0.106 -9999.0 0.0 -0.284 13.0 13.0 RAPGEF1 0.054 0.111 0.349 2.0 -0.407 3.0 5.0 CTNND1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.023 0.093 -9999.0 0.0 -0.444 5.0 5.0 CRK 0.051 0.11 -9999.0 0.0 -0.439 3.0 3.0 E-cadherin/gamma catenin/alpha catenin 0.052 0.064 -9999.0 0.0 -0.317 4.0 4.0 alphaE/beta7 Integrin 0.015 0.099 -9999.0 0.0 -0.365 9.0 9.0 IQGAP1 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.03 0.029 -9999.0 0.0 -0.321 1.0 1.0 Rap1/GTP/I-afadin 0.057 0.017 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.017 0.089 -9999.0 0.0 -0.433 5.0 5.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.0 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.051 0.029 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.005 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.035 0.069 -9999.0 0.0 -0.373 4.0 4.0 TIAM1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.062 0.061 -9999.0 0.0 -0.272 4.0 4.0 AKT1 0.037 0.048 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.017 0.089 -9999.0 0.0 -0.515 4.0 4.0 RhoA/GDP 0.088 0.099 0.323 2.0 -0.278 2.0 4.0 actin cytoskeleton organization 0.038 0.075 0.189 9.0 -0.17 2.0 11.0 CDC42/GDP 0.079 0.101 0.323 2.0 -0.283 1.0 3.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.02 0.045 -9999.0 0.0 -0.243 4.0 4.0 ITGB7 -0.002 0.131 -9999.0 0.0 -0.514 9.0 9.0 RAC1 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.067 0.065 -9999.0 0.0 -0.289 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.045 0.057 -9999.0 0.0 -0.271 4.0 4.0 mol:GDP 0.075 0.107 0.329 2.0 -0.313 3.0 5.0 CDC42/GTP/IQGAP1 0.038 0.015 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 p120 catenin/RhoA/GDP 0.095 0.102 0.328 2.0 -0.29 1.0 3.0 RAC1/GTP/IQGAP1 0.037 0.016 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.047 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.02 0.077 0.154 10.0 -0.131 14.0 24.0 NME1 0.028 0.03 -9999.0 0.0 -0.321 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.015 0.089 -9999.0 0.0 -0.433 5.0 5.0 regulation of cell-cell adhesion 0.01 0.034 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.013 0.038 -9999.0 0.0 -0.133 1.0 1.0 Rap1/GTP 0.087 0.088 0.321 2.0 -9999.0 0.0 2.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.047 0.105 -9999.0 0.0 -0.267 13.0 13.0 CCND1 0.02 0.088 0.165 9.0 -0.159 15.0 24.0 VAV2 0.068 0.167 -9999.0 0.0 -0.646 4.0 4.0 RAP1/GDP 0.092 0.096 0.336 2.0 -9999.0 0.0 2.0 adherens junction assembly 0.015 0.087 -9999.0 0.0 -0.419 5.0 5.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.031 0.096 -9999.0 0.0 -0.258 12.0 12.0 E-cadherin/beta catenin 0.006 0.063 -9999.0 0.0 -0.365 4.0 4.0 mol:GTP -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.006 0.079 -9999.0 0.0 -0.424 4.0 4.0 PIK3CA 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.031 0.074 -9999.0 0.0 -0.33 5.0 5.0 E-cadherin/beta catenin/alpha catenin 0.051 0.066 -9999.0 0.0 -0.317 4.0 4.0 ITGAE 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.023 0.095 -9999.0 0.0 -0.454 5.0 5.0