Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 0.026 0.094 -9999.0 0.0 -0.723 1.0 1.0 IHH 0.032 0.063 -9999.0 0.0 -0.63 1.0 1.0 SHH Np/Cholesterol/GAS1 -0.057 0.151 -9999.0 0.0 -0.323 30.0 30.0 LRPAP1 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.057 0.15 0.321 30.0 -9999.0 0.0 30.0 SMO/beta Arrestin2 0.041 0.079 -9999.0 0.0 -0.539 1.0 1.0 SMO 0.026 0.071 -9999.0 0.0 -0.565 1.0 1.0 AKT1 0.011 0.112 -9999.0 0.0 -0.384 3.0 3.0 ARRB2 0.026 0.013 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 STIL -0.012 0.118 -9999.0 0.0 -0.373 6.0 6.0 DHH N/PTCH2 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 DHH N/PTCH1 0.044 0.07 -9999.0 0.0 -0.499 1.0 1.0 PIK3CA 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 PTHLH 0.025 0.099 -9999.0 0.0 -0.885 1.0 1.0 determination of left/right symmetry 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 PIK3R1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development 0.025 0.098 -9999.0 0.0 -0.874 1.0 1.0 IHH N/Hhip -0.047 0.192 -9999.0 0.0 -0.418 30.0 30.0 DHH N/Hhip -0.04 0.17 -9999.0 0.0 -0.373 30.0 30.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 pancreas development -0.08 0.22 -9999.0 0.0 -0.514 30.0 30.0 HHAT -0.017 0.156 -9999.0 0.0 -0.514 13.0 13.0 PI3K 0.047 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.076 0.208 -9999.0 0.0 -0.46 32.0 32.0 somite specification 0.026 0.07 -9999.0 0.0 -0.556 1.0 1.0 SHH Np/Cholesterol/PTCH1 0.008 0.099 -9999.0 0.0 -0.379 3.0 3.0 SHH Np/Cholesterol/PTCH2 0.002 0.092 -9999.0 0.0 -0.286 13.0 13.0 SHH Np/Cholesterol/Megalin 0.002 0.093 -9999.0 0.0 -0.287 13.0 13.0 SHH -0.017 0.115 0.229 1.0 -0.362 14.0 15.0 catabolic process 0.03 0.072 -9999.0 0.0 -0.552 1.0 1.0 SMO/Vitamin D3 0.009 0.1 -9999.0 0.0 -0.499 1.0 1.0 SHH Np/Cholesterol/Hhip -0.059 0.157 -9999.0 0.0 -0.319 36.0 36.0 LRP2 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis 0.007 0.098 -9999.0 0.0 -0.461 1.0 1.0 SHH Np/Cholesterol/BOC 0.003 0.09 -9999.0 0.0 -0.287 12.0 12.0 SHH Np/Cholesterol/CDO 0.002 0.093 -9999.0 0.0 -0.287 13.0 13.0 mesenchymal cell differentiation 0.059 0.156 0.317 36.0 -9999.0 0.0 36.0 mol:Vitamin D3 0.015 0.106 -9999.0 0.0 -0.38 3.0 3.0 IHH N/PTCH2 0.047 0.039 -9999.0 0.0 -0.393 1.0 1.0 CDON 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 0.038 0.075 -9999.0 0.0 -0.559 1.0 1.0 Megalin/LRPAP1 0.045 0.011 -9999.0 0.0 -9999.0 0.0 0.0 PTCH2 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.01 0.089 -9999.0 0.0 -0.287 13.0 13.0 PTCH1 0.03 0.072 -9999.0 0.0 -0.554 1.0 1.0 HHIP -0.08 0.221 -9999.0 0.0 -0.514 30.0 30.0