This pipeline computes the correlation between significant copy number variation (cnv focal) genes and selected clinical features.
Testing the association between copy number variation 73 focal events and 13 clinical features across 604 patients, 73 significant findings detected with Q value < 0.25.
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amp_6p21.1 cnv correlated to 'PATHOLOGY.N.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
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amp_7p21.3 cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', and 'NUMBER.OF.LYMPH.NODES'.
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amp_13q12.13 cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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amp_13q12.2 cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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amp_13q22.1 cnv correlated to 'PATHOLOGY.N.STAGE' and 'HISTOLOGICAL.TYPE'.
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amp_16p11.2 cnv correlated to 'PATHOLOGY.N.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
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amp_20p11.21 cnv correlated to 'HISTOLOGICAL.TYPE'.
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amp_20q11.21 cnv correlated to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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amp_20q12 cnv correlated to 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', and 'HISTOLOGICAL.TYPE'.
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amp_20q13.31 cnv correlated to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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del_1p36.11 cnv correlated to 'PATHOLOGY.M.STAGE'.
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del_4p16.2 cnv correlated to 'RADIATIONS.RADIATION.REGIMENINDICATION' and 'NUMBER.OF.LYMPH.NODES'.
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del_4q22.1 cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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del_4q35.1 cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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del_5q12.1 cnv correlated to 'RADIATIONS.RADIATION.REGIMENINDICATION'.
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del_8p23.2 cnv correlated to 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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del_8p22 cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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del_14q11.2 cnv correlated to 'HISTOLOGICAL.TYPE'.
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del_14q31.1 cnv correlated to 'HISTOLOGICAL.TYPE'.
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del_17p12 cnv correlated to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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del_17q24.3 cnv correlated to 'NUMBER.OF.LYMPH.NODES'.
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del_18p11.31 cnv correlated to 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.M.STAGE', and 'HISTOLOGICAL.TYPE'.
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del_18q12.2 cnv correlated to 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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del_18q21.2 cnv correlated to 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'PATHOLOGY.M.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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del_18q22.1 cnv correlated to 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.N.STAGE', 'PATHOLOGY.M.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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del_19p13.3 cnv correlated to 'PATHOLOGY.N.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
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del_21q11.2 cnv correlated to 'HISTOLOGICAL.TYPE'.
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del_22q13.32 cnv correlated to 'PATHOLOGY.N.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
Clinical Features |
Time to Death |
AGE |
PRIMARY SITE OF DISEASE |
NEOPLASM DISEASESTAGE |
PATHOLOGY T STAGE |
PATHOLOGY N STAGE |
PATHOLOGY M STAGE |
GENDER |
HISTOLOGICAL TYPE |
RADIATIONS RADIATION REGIMENINDICATION |
COMPLETENESS OF RESECTION |
NUMBER OF LYMPH NODES |
RACE | ||
nCNV (%) | nWild-Type | logrank test | Wilcoxon-test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Fisher's exact test | Wilcoxon-test | Fisher's exact test | |
del 18q21 2 | 425 (70%) | 179 |
0.84 (1.00) |
0.0206 (1.00) |
3.46e-09 (3.28e-06) |
1e-05 (0.00937) |
0.317 (1.00) |
2e-05 (0.0183) |
0.00013 (0.115) |
0.109 (1.00) |
1e-05 (0.00937) |
0.0641 (1.00) |
0.0392 (1.00) |
1.61e-06 (0.00152) |
0.663 (1.00) |
del 18q22 1 | 420 (70%) | 184 |
0.955 (1.00) |
0.061 (1.00) |
1.6e-07 (0.000152) |
1e-05 (0.00937) |
0.453 (1.00) |
2e-05 (0.0183) |
0.00027 (0.237) |
0.132 (1.00) |
1e-05 (0.00937) |
0.0634 (1.00) |
0.078 (1.00) |
1.54e-05 (0.0142) |
0.365 (1.00) |
del 8p23 2 | 284 (47%) | 320 |
0.538 (1.00) |
0.146 (1.00) |
7.01e-05 (0.0631) |
5e-05 (0.0452) |
0.0769 (1.00) |
1e-05 (0.00937) |
0.00228 (1.00) |
0.034 (1.00) |
7e-05 (0.0631) |
0.0911 (1.00) |
0.0101 (1.00) |
3.56e-06 (0.00335) |
0.537 (1.00) |
del 18q12 2 | 408 (68%) | 196 |
0.957 (1.00) |
0.0136 (1.00) |
1.4e-09 (1.32e-06) |
0.00026 (0.229) |
0.343 (1.00) |
7e-05 (0.0631) |
0.0015 (1.00) |
0.297 (1.00) |
1e-05 (0.00937) |
0.0351 (1.00) |
0.0417 (1.00) |
0.000195 (0.173) |
0.39 (1.00) |
amp 13q12 13 | 393 (65%) | 211 |
0.293 (1.00) |
0.474 (1.00) |
0.000513 (0.441) |
3e-05 (0.0274) |
0.78 (1.00) |
2e-05 (0.0183) |
0.00168 (1.00) |
0.609 (1.00) |
1e-05 (0.00937) |
0.506 (1.00) |
0.0463 (1.00) |
7.11e-05 (0.0639) |
0.0181 (1.00) |
amp 13q12 2 | 388 (64%) | 216 |
0.405 (1.00) |
0.419 (1.00) |
0.000394 (0.343) |
6e-05 (0.0542) |
0.845 (1.00) |
2e-05 (0.0183) |
0.00636 (1.00) |
0.444 (1.00) |
1e-05 (0.00937) |
0.501 (1.00) |
0.0832 (1.00) |
8.9e-05 (0.0797) |
0.026 (1.00) |
del 8p22 | 296 (49%) | 308 |
0.11 (1.00) |
0.193 (1.00) |
0.000663 (0.567) |
1e-05 (0.00937) |
0.0234 (1.00) |
2e-05 (0.0183) |
0.00046 (0.398) |
0.122 (1.00) |
0.0001 (0.0892) |
0.101 (1.00) |
0.0065 (1.00) |
4.28e-08 (4.05e-05) |
0.259 (1.00) |
del 17p12 | 361 (60%) | 243 |
0.489 (1.00) |
0.145 (1.00) |
0.00197 (1.00) |
0.00023 (0.203) |
0.45 (1.00) |
6e-05 (0.0542) |
0.0199 (1.00) |
0.507 (1.00) |
1e-05 (0.00937) |
0.326 (1.00) |
0.155 (1.00) |
9.69e-06 (0.00909) |
0.767 (1.00) |
del 18p11 31 | 363 (60%) | 241 |
0.705 (1.00) |
0.00817 (1.00) |
2.45e-06 (0.00231) |
9e-05 (0.0805) |
0.896 (1.00) |
0.00829 (1.00) |
3e-05 (0.0274) |
0.74 (1.00) |
1e-05 (0.00937) |
0.328 (1.00) |
0.0207 (1.00) |
0.00908 (1.00) |
0.778 (1.00) |
amp 7p21 3 | 357 (59%) | 247 |
0.625 (1.00) |
0.0449 (1.00) |
0.0248 (1.00) |
8e-05 (0.0718) |
0.931 (1.00) |
1e-05 (0.00937) |
0.052 (1.00) |
1 (1.00) |
0.00104 (0.887) |
0.0898 (1.00) |
0.295 (1.00) |
3.5e-05 (0.0317) |
0.597 (1.00) |
amp 20q12 | 461 (76%) | 143 |
0.706 (1.00) |
0.508 (1.00) |
1.51e-06 (0.00143) |
0.00024 (0.212) |
0.355 (1.00) |
0.00035 (0.307) |
0.00276 (1.00) |
0.252 (1.00) |
1e-05 (0.00937) |
0.693 (1.00) |
0.0387 (1.00) |
0.00279 (1.00) |
0.161 (1.00) |
amp 6p21 1 | 152 (25%) | 452 |
0.644 (1.00) |
0.819 (1.00) |
0.0254 (1.00) |
0.0131 (1.00) |
0.239 (1.00) |
0.00013 (0.115) |
0.059 (1.00) |
0.133 (1.00) |
0.00438 (1.00) |
0.00129 (1.00) |
0.113 (1.00) |
0.000262 (0.23) |
0.151 (1.00) |
amp 13q22 1 | 391 (65%) | 213 |
0.427 (1.00) |
0.7 (1.00) |
0.0165 (1.00) |
0.00059 (0.506) |
0.739 (1.00) |
3e-05 (0.0274) |
0.00916 (1.00) |
0.173 (1.00) |
1e-05 (0.00937) |
0.504 (1.00) |
0.256 (1.00) |
0.000406 (0.354) |
0.0969 (1.00) |
amp 16p11 2 | 169 (28%) | 435 |
0.806 (1.00) |
0.288 (1.00) |
0.759 (1.00) |
0.00042 (0.365) |
0.718 (1.00) |
3e-05 (0.0274) |
0.176 (1.00) |
0.928 (1.00) |
0.00247 (1.00) |
0.275 (1.00) |
0.278 (1.00) |
3.32e-05 (0.0301) |
0.559 (1.00) |
amp 20q11 21 | 459 (76%) | 145 |
0.58 (1.00) |
0.603 (1.00) |
2.99e-06 (0.00282) |
0.00076 (0.649) |
0.265 (1.00) |
0.00051 (0.439) |
0.0184 (1.00) |
0.254 (1.00) |
1e-05 (0.00937) |
0.694 (1.00) |
0.0397 (1.00) |
0.00267 (1.00) |
0.278 (1.00) |
amp 20q13 31 | 464 (77%) | 140 |
0.655 (1.00) |
0.54 (1.00) |
2.4e-06 (0.00226) |
0.00041 (0.356) |
0.224 (1.00) |
0.00046 (0.398) |
0.0036 (1.00) |
0.44 (1.00) |
1e-05 (0.00937) |
0.692 (1.00) |
0.0396 (1.00) |
0.00252 (1.00) |
0.157 (1.00) |
del 4p16 2 | 193 (32%) | 411 |
0.124 (1.00) |
0.895 (1.00) |
0.0481 (1.00) |
0.00272 (1.00) |
0.823 (1.00) |
0.00047 (0.406) |
0.00237 (1.00) |
0.162 (1.00) |
0.0177 (1.00) |
3.05e-05 (0.0277) |
0.0923 (1.00) |
9.72e-05 (0.0868) |
0.37 (1.00) |
del 19p13 3 | 95 (16%) | 509 |
0.277 (1.00) |
0.254 (1.00) |
0.0584 (1.00) |
0.00676 (1.00) |
0.399 (1.00) |
0.0001 (0.0892) |
0.028 (1.00) |
0.37 (1.00) |
0.0891 (1.00) |
0.638 (1.00) |
0.147 (1.00) |
4.71e-06 (0.00443) |
0.873 (1.00) |
del 22q13 32 | 222 (37%) | 382 |
0.026 (1.00) |
0.96 (1.00) |
0.214 (1.00) |
0.014 (1.00) |
0.369 (1.00) |
0.00028 (0.246) |
0.0258 (1.00) |
0.399 (1.00) |
0.00396 (1.00) |
0.731 (1.00) |
0.402 (1.00) |
0.000266 (0.234) |
0.643 (1.00) |
amp 20p11 21 | 355 (59%) | 249 |
0.508 (1.00) |
0.708 (1.00) |
0.00669 (1.00) |
0.0125 (1.00) |
0.777 (1.00) |
0.363 (1.00) |
0.00576 (1.00) |
0.0684 (1.00) |
1e-05 (0.00937) |
0.319 (1.00) |
0.402 (1.00) |
0.66 (1.00) |
0.482 (1.00) |
del 1p36 11 | 239 (40%) | 365 |
0.0943 (1.00) |
0.0466 (1.00) |
0.0903 (1.00) |
0.00343 (1.00) |
0.31 (1.00) |
0.00368 (1.00) |
0.00012 (0.107) |
0.211 (1.00) |
0.0022 (1.00) |
0.745 (1.00) |
0.0856 (1.00) |
0.000352 (0.308) |
0.328 (1.00) |
del 4q22 1 | 215 (36%) | 389 |
0.33 (1.00) |
0.157 (1.00) |
0.0159 (1.00) |
0.0268 (1.00) |
0.136 (1.00) |
0.00038 (0.332) |
0.464 (1.00) |
0.106 (1.00) |
0.00163 (1.00) |
0.00147 (1.00) |
0.792 (1.00) |
0.000108 (0.0959) |
0.818 (1.00) |
del 4q35 1 | 224 (37%) | 380 |
0.898 (1.00) |
0.102 (1.00) |
0.0705 (1.00) |
0.058 (1.00) |
0.589 (1.00) |
0.00105 (0.895) |
0.361 (1.00) |
1 (1.00) |
0.0441 (1.00) |
0.00202 (1.00) |
0.765 (1.00) |
0.000206 (0.182) |
0.558 (1.00) |
del 5q12 1 | 153 (25%) | 451 |
0.167 (1.00) |
0.119 (1.00) |
0.0154 (1.00) |
0.0274 (1.00) |
0.995 (1.00) |
0.00876 (1.00) |
0.00957 (1.00) |
0.513 (1.00) |
0.00998 (1.00) |
0.000104 (0.0926) |
0.642 (1.00) |
0.00515 (1.00) |
0.403 (1.00) |
del 14q11 2 | 206 (34%) | 398 |
0.551 (1.00) |
0.216 (1.00) |
0.0116 (1.00) |
0.792 (1.00) |
0.298 (1.00) |
0.0487 (1.00) |
0.199 (1.00) |
1 (1.00) |
1e-05 (0.00937) |
0.499 (1.00) |
0.875 (1.00) |
0.144 (1.00) |
1 (1.00) |
del 14q31 1 | 212 (35%) | 392 |
0.974 (1.00) |
0.106 (1.00) |
0.0339 (1.00) |
0.576 (1.00) |
0.208 (1.00) |
0.0395 (1.00) |
0.0427 (1.00) |
0.393 (1.00) |
1e-05 (0.00937) |
0.505 (1.00) |
0.737 (1.00) |
0.0394 (1.00) |
0.981 (1.00) |
del 17q24 3 | 94 (16%) | 510 |
0.0832 (1.00) |
0.184 (1.00) |
1 (1.00) |
0.00928 (1.00) |
0.0962 (1.00) |
0.00188 (1.00) |
0.00194 (1.00) |
0.179 (1.00) |
0.978 (1.00) |
0.636 (1.00) |
0.388 (1.00) |
5.44e-05 (0.0492) |
0.172 (1.00) |
del 21q11 2 | 209 (35%) | 395 |
0.349 (1.00) |
0.698 (1.00) |
0.00362 (1.00) |
0.427 (1.00) |
0.934 (1.00) |
0.0731 (1.00) |
0.5 (1.00) |
0.668 (1.00) |
8e-05 (0.0718) |
0.288 (1.00) |
0.608 (1.00) |
0.0138 (1.00) |
0.503 (1.00) |
amp 1q31 1 | 143 (24%) | 461 |
0.619 (1.00) |
0.234 (1.00) |
0.0649 (1.00) |
0.327 (1.00) |
0.315 (1.00) |
0.0563 (1.00) |
0.185 (1.00) |
0.212 (1.00) |
0.149 (1.00) |
0.0382 (1.00) |
0.728 (1.00) |
0.00948 (1.00) |
0.949 (1.00) |
amp 2q33 1 | 137 (23%) | 467 |
0.0831 (1.00) |
0.924 (1.00) |
0.0115 (1.00) |
0.0376 (1.00) |
0.894 (1.00) |
0.00178 (1.00) |
0.177 (1.00) |
0.923 (1.00) |
0.00107 (0.911) |
0.124 (1.00) |
0.383 (1.00) |
0.00264 (1.00) |
0.236 (1.00) |
amp 5p12 | 116 (19%) | 488 |
0.092 (1.00) |
0.148 (1.00) |
0.048 (1.00) |
0.283 (1.00) |
0.466 (1.00) |
0.0432 (1.00) |
0.203 (1.00) |
0.679 (1.00) |
0.016 (1.00) |
0.385 (1.00) |
0.0571 (1.00) |
0.00979 (1.00) |
0.58 (1.00) |
amp 5q22 3 | 63 (10%) | 541 |
0.274 (1.00) |
0.856 (1.00) |
0.371 (1.00) |
0.605 (1.00) |
0.961 (1.00) |
0.31 (1.00) |
0.084 (1.00) |
0.895 (1.00) |
0.216 (1.00) |
1 (1.00) |
0.0572 (1.00) |
0.182 (1.00) |
0.606 (1.00) |
amp 8p11 23 | 208 (34%) | 396 |
0.376 (1.00) |
0.802 (1.00) |
0.563 (1.00) |
0.299 (1.00) |
0.554 (1.00) |
0.541 (1.00) |
0.258 (1.00) |
0.607 (1.00) |
0.247 (1.00) |
0.503 (1.00) |
0.0816 (1.00) |
0.835 (1.00) |
0.795 (1.00) |
amp 8p11 21 | 252 (42%) | 352 |
0.634 (1.00) |
0.478 (1.00) |
0.78 (1.00) |
0.125 (1.00) |
0.507 (1.00) |
0.389 (1.00) |
0.16 (1.00) |
0.187 (1.00) |
0.196 (1.00) |
0.741 (1.00) |
0.0252 (1.00) |
0.561 (1.00) |
0.642 (1.00) |
amp 8q12 1 | 325 (54%) | 279 |
0.669 (1.00) |
0.104 (1.00) |
0.357 (1.00) |
0.0674 (1.00) |
0.334 (1.00) |
0.103 (1.00) |
0.0111 (1.00) |
0.414 (1.00) |
0.016 (1.00) |
0.0425 (1.00) |
0.0905 (1.00) |
0.117 (1.00) |
0.454 (1.00) |
amp 8q24 21 | 362 (60%) | 242 |
0.383 (1.00) |
0.166 (1.00) |
0.0753 (1.00) |
0.0826 (1.00) |
0.286 (1.00) |
0.149 (1.00) |
0.0229 (1.00) |
0.213 (1.00) |
0.0129 (1.00) |
0.093 (1.00) |
0.194 (1.00) |
0.207 (1.00) |
0.64 (1.00) |
amp 10q22 3 | 38 (6%) | 566 |
0.941 (1.00) |
0.267 (1.00) |
0.85 (1.00) |
0.577 (1.00) |
0.193 (1.00) |
0.0443 (1.00) |
0.76 (1.00) |
0.616 (1.00) |
0.903 (1.00) |
0.445 (1.00) |
0.928 (1.00) |
0.0624 (1.00) |
0.912 (1.00) |
amp 11p15 5 | 135 (22%) | 469 |
0.752 (1.00) |
0.0368 (1.00) |
0.0773 (1.00) |
0.867 (1.00) |
0.287 (1.00) |
0.365 (1.00) |
0.286 (1.00) |
0.769 (1.00) |
0.00047 (0.406) |
0.118 (1.00) |
0.844 (1.00) |
0.326 (1.00) |
0.554 (1.00) |
amp 12p13 32 | 149 (25%) | 455 |
0.233 (1.00) |
0.165 (1.00) |
0.749 (1.00) |
0.0836 (1.00) |
0.377 (1.00) |
0.0971 (1.00) |
0.121 (1.00) |
0.777 (1.00) |
0.508 (1.00) |
0.696 (1.00) |
0.752 (1.00) |
0.355 (1.00) |
0.697 (1.00) |
amp 15q26 1 | 42 (7%) | 562 |
0.304 (1.00) |
0.781 (1.00) |
0.589 (1.00) |
0.14 (1.00) |
0.337 (1.00) |
0.0023 (1.00) |
0.569 (1.00) |
0.2 (1.00) |
0.533 (1.00) |
0.125 (1.00) |
0.494 (1.00) |
0.00375 (1.00) |
0.714 (1.00) |
amp 17q12 | 157 (26%) | 447 |
0.0562 (1.00) |
0.169 (1.00) |
0.465 (1.00) |
0.304 (1.00) |
0.297 (1.00) |
0.156 (1.00) |
0.00993 (1.00) |
0.115 (1.00) |
0.318 (1.00) |
0.458 (1.00) |
0.0462 (1.00) |
0.248 (1.00) |
0.178 (1.00) |
amp 17q24 1 | 140 (23%) | 464 |
0.0105 (1.00) |
0.241 (1.00) |
0.914 (1.00) |
0.745 (1.00) |
0.788 (1.00) |
0.983 (1.00) |
0.0807 (1.00) |
0.562 (1.00) |
0.0639 (1.00) |
0.692 (1.00) |
0.106 (1.00) |
0.632 (1.00) |
0.851 (1.00) |
amp 19p13 2 | 109 (18%) | 495 |
0.673 (1.00) |
0.707 (1.00) |
0.122 (1.00) |
0.739 (1.00) |
0.404 (1.00) |
0.0846 (1.00) |
0.276 (1.00) |
0.205 (1.00) |
0.0353 (1.00) |
1 (1.00) |
0.114 (1.00) |
0.467 (1.00) |
0.541 (1.00) |
amp 19q12 | 136 (23%) | 468 |
0.661 (1.00) |
0.468 (1.00) |
0.124 (1.00) |
0.51 (1.00) |
0.833 (1.00) |
0.105 (1.00) |
0.0544 (1.00) |
0.205 (1.00) |
0.0136 (1.00) |
1 (1.00) |
0.414 (1.00) |
0.275 (1.00) |
0.734 (1.00) |
amp 20p12 1 | 274 (45%) | 330 |
0.28 (1.00) |
0.494 (1.00) |
0.166 (1.00) |
0.003 (1.00) |
0.896 (1.00) |
0.127 (1.00) |
0.00147 (1.00) |
0.0332 (1.00) |
0.0078 (1.00) |
0.0866 (1.00) |
0.0674 (1.00) |
0.134 (1.00) |
0.71 (1.00) |
del 1p33 | 172 (28%) | 432 |
0.0596 (1.00) |
0.6 (1.00) |
0.309 (1.00) |
0.0348 (1.00) |
0.32 (1.00) |
0.0224 (1.00) |
0.0312 (1.00) |
0.653 (1.00) |
0.0341 (1.00) |
0.719 (1.00) |
0.286 (1.00) |
0.00539 (1.00) |
0.27 (1.00) |
del 1p13 2 | 171 (28%) | 433 |
0.0609 (1.00) |
0.753 (1.00) |
0.22 (1.00) |
0.00726 (1.00) |
0.186 (1.00) |
0.00636 (1.00) |
0.00598 (1.00) |
0.588 (1.00) |
0.082 (1.00) |
0.28 (1.00) |
0.353 (1.00) |
0.000483 (0.416) |
0.448 (1.00) |
del 2p12 | 21 (3%) | 583 |
0.991 (1.00) |
0.128 (1.00) |
0.000669 (0.572) |
0.407 (1.00) |
1 (1.00) |
0.443 (1.00) |
0.351 (1.00) |
0.66 (1.00) |
0.00613 (1.00) |
0.274 (1.00) |
0.885 (1.00) |
0.399 (1.00) |
0.676 (1.00) |
del 2q22 1 | 35 (6%) | 569 |
0.823 (1.00) |
0.836 (1.00) |
0.558 (1.00) |
0.325 (1.00) |
0.637 (1.00) |
0.505 (1.00) |
0.418 (1.00) |
0.728 (1.00) |
0.906 (1.00) |
1 (1.00) |
0.931 (1.00) |
0.239 (1.00) |
0.0123 (1.00) |
del 3p26 3 | 90 (15%) | 514 |
0.0737 (1.00) |
0.453 (1.00) |
0.365 (1.00) |
0.0332 (1.00) |
0.0891 (1.00) |
0.00888 (1.00) |
0.00531 (1.00) |
0.648 (1.00) |
0.061 (1.00) |
0.629 (1.00) |
0.0668 (1.00) |
0.0053 (1.00) |
0.601 (1.00) |
del 3p14 2 | 116 (19%) | 488 |
0.331 (1.00) |
0.241 (1.00) |
0.726 (1.00) |
0.225 (1.00) |
0.106 (1.00) |
0.208 (1.00) |
0.0948 (1.00) |
0.535 (1.00) |
0.721 (1.00) |
0.685 (1.00) |
0.297 (1.00) |
0.0891 (1.00) |
0.504 (1.00) |
del 3q26 31 | 62 (10%) | 542 |
0.43 (1.00) |
0.808 (1.00) |
0.88 (1.00) |
0.0349 (1.00) |
0.102 (1.00) |
0.0941 (1.00) |
0.152 (1.00) |
0.424 (1.00) |
0.00928 (1.00) |
1 (1.00) |
0.818 (1.00) |
0.159 (1.00) |
0.633 (1.00) |
del 5q21 2 | 182 (30%) | 422 |
0.119 (1.00) |
0.144 (1.00) |
0.271 (1.00) |
0.00582 (1.00) |
0.754 (1.00) |
0.00038 (0.332) |
0.0171 (1.00) |
0.859 (1.00) |
0.0564 (1.00) |
0.000406 (0.354) |
0.619 (1.00) |
0.000521 (0.448) |
0.577 (1.00) |
del 5q22 2 | 184 (30%) | 420 |
0.0947 (1.00) |
0.387 (1.00) |
0.0726 (1.00) |
0.0345 (1.00) |
0.735 (1.00) |
0.0117 (1.00) |
0.0175 (1.00) |
0.376 (1.00) |
0.0392 (1.00) |
0.000442 (0.383) |
0.268 (1.00) |
0.00946 (1.00) |
0.543 (1.00) |
del 6p25 3 | 78 (13%) | 526 |
0.0765 (1.00) |
0.0621 (1.00) |
0.889 (1.00) |
0.458 (1.00) |
0.473 (1.00) |
0.493 (1.00) |
0.396 (1.00) |
0.0694 (1.00) |
0.49 (1.00) |
0.328 (1.00) |
0.46 (1.00) |
0.455 (1.00) |
0.0051 (1.00) |
del 6q26 | 91 (15%) | 513 |
0.0176 (1.00) |
0.708 (1.00) |
0.303 (1.00) |
0.188 (1.00) |
0.163 (1.00) |
0.00301 (1.00) |
0.107 (1.00) |
0.211 (1.00) |
0.0397 (1.00) |
0.631 (1.00) |
0.184 (1.00) |
0.00225 (1.00) |
0.0235 (1.00) |
del 7q31 1 | 16 (3%) | 588 |
0.989 (1.00) |
0.557 (1.00) |
1 (1.00) |
0.723 (1.00) |
0.493 (1.00) |
0.939 (1.00) |
0.113 (1.00) |
0.46 (1.00) |
0.489 (1.00) |
1 (1.00) |
0.634 (1.00) |
0.698 (1.00) |
0.57 (1.00) |
del 8q11 1 | 47 (8%) | 557 |
0.381 (1.00) |
0.309 (1.00) |
0.228 (1.00) |
0.154 (1.00) |
0.681 (1.00) |
0.0555 (1.00) |
0.0434 (1.00) |
0.228 (1.00) |
0.564 (1.00) |
0.52 (1.00) |
0.322 (1.00) |
0.0271 (1.00) |
0.0747 (1.00) |
del 9p24 2 | 82 (14%) | 522 |
0.345 (1.00) |
0.106 (1.00) |
0.283 (1.00) |
0.78 (1.00) |
0.437 (1.00) |
0.122 (1.00) |
0.115 (1.00) |
0.0564 (1.00) |
0.119 (1.00) |
0.351 (1.00) |
0.137 (1.00) |
0.0332 (1.00) |
0.719 (1.00) |
del 10p15 3 | 112 (19%) | 492 |
0.483 (1.00) |
0.0322 (1.00) |
0.345 (1.00) |
0.0399 (1.00) |
0.619 (1.00) |
0.0198 (1.00) |
0.114 (1.00) |
0.834 (1.00) |
0.419 (1.00) |
0.0135 (1.00) |
0.867 (1.00) |
0.00396 (1.00) |
0.71 (1.00) |
del 10q21 1 | 135 (22%) | 469 |
0.692 (1.00) |
0.0327 (1.00) |
0.44 (1.00) |
0.0892 (1.00) |
0.92 (1.00) |
0.0709 (1.00) |
0.366 (1.00) |
0.845 (1.00) |
0.0409 (1.00) |
0.0301 (1.00) |
0.273 (1.00) |
0.0244 (1.00) |
0.686 (1.00) |
del 10q23 31 | 157 (26%) | 447 |
0.506 (1.00) |
0.00482 (1.00) |
0.0745 (1.00) |
0.0435 (1.00) |
0.59 (1.00) |
0.0556 (1.00) |
0.0577 (1.00) |
1 (1.00) |
0.0127 (1.00) |
0.0116 (1.00) |
0.699 (1.00) |
0.0144 (1.00) |
0.91 (1.00) |
del 10q25 2 | 154 (25%) | 450 |
0.371 (1.00) |
0.0409 (1.00) |
0.246 (1.00) |
0.171 (1.00) |
0.308 (1.00) |
0.0193 (1.00) |
0.318 (1.00) |
0.926 (1.00) |
0.034 (1.00) |
0.0105 (1.00) |
0.676 (1.00) |
0.0132 (1.00) |
1 (1.00) |
del 11q22 3 | 109 (18%) | 495 |
0.297 (1.00) |
0.48 (1.00) |
0.07 (1.00) |
0.682 (1.00) |
0.674 (1.00) |
0.193 (1.00) |
0.368 (1.00) |
0.751 (1.00) |
0.0416 (1.00) |
0.21 (1.00) |
0.55 (1.00) |
0.0526 (1.00) |
0.252 (1.00) |
del 12p13 1 | 89 (15%) | 515 |
0.0474 (1.00) |
0.215 (1.00) |
0.149 (1.00) |
0.232 (1.00) |
0.547 (1.00) |
0.0295 (1.00) |
0.0759 (1.00) |
0.818 (1.00) |
0.0175 (1.00) |
0.628 (1.00) |
0.902 (1.00) |
0.0952 (1.00) |
0.925 (1.00) |
del 12q21 33 | 88 (15%) | 516 |
0.134 (1.00) |
0.869 (1.00) |
0.363 (1.00) |
0.0663 (1.00) |
0.637 (1.00) |
0.0705 (1.00) |
0.451 (1.00) |
0.645 (1.00) |
0.031 (1.00) |
0.626 (1.00) |
0.548 (1.00) |
0.0191 (1.00) |
0.961 (1.00) |
del 15q11 2 | 246 (41%) | 358 |
0.89 (1.00) |
0.337 (1.00) |
0.134 (1.00) |
0.0741 (1.00) |
0.766 (1.00) |
0.0127 (1.00) |
0.0846 (1.00) |
0.407 (1.00) |
0.0497 (1.00) |
0.0356 (1.00) |
0.829 (1.00) |
0.00382 (1.00) |
0.195 (1.00) |
del 15q15 2 | 243 (40%) | 361 |
0.984 (1.00) |
0.202 (1.00) |
0.0244 (1.00) |
0.0507 (1.00) |
0.759 (1.00) |
0.00297 (1.00) |
0.0237 (1.00) |
0.28 (1.00) |
0.0122 (1.00) |
0.0344 (1.00) |
0.531 (1.00) |
0.00186 (1.00) |
0.122 (1.00) |
del 15q21 1 | 241 (40%) | 363 |
0.621 (1.00) |
0.424 (1.00) |
0.024 (1.00) |
0.122 (1.00) |
0.815 (1.00) |
0.0161 (1.00) |
0.0374 (1.00) |
0.212 (1.00) |
0.0122 (1.00) |
0.0336 (1.00) |
0.447 (1.00) |
0.00846 (1.00) |
0.0624 (1.00) |
del 15q22 33 | 231 (38%) | 373 |
0.881 (1.00) |
0.268 (1.00) |
0.0136 (1.00) |
0.00794 (1.00) |
0.0794 (1.00) |
0.00169 (1.00) |
0.0396 (1.00) |
0.402 (1.00) |
0.0074 (1.00) |
0.00255 (1.00) |
0.58 (1.00) |
0.000652 (0.559) |
0.0468 (1.00) |
del 16p13 3 | 67 (11%) | 537 |
0.00137 (1.00) |
0.772 (1.00) |
0.147 (1.00) |
0.0117 (1.00) |
0.0605 (1.00) |
0.184 (1.00) |
0.275 (1.00) |
0.795 (1.00) |
0.227 (1.00) |
0.607 (1.00) |
0.438 (1.00) |
0.128 (1.00) |
0.256 (1.00) |
del 16q23 1 | 81 (13%) | 523 |
0.0102 (1.00) |
0.671 (1.00) |
0.788 (1.00) |
0.349 (1.00) |
0.188 (1.00) |
0.55 (1.00) |
0.463 (1.00) |
0.341 (1.00) |
0.774 (1.00) |
1 (1.00) |
0.891 (1.00) |
0.971 (1.00) |
0.3 (1.00) |
del 20p12 1 | 132 (22%) | 472 |
0.689 (1.00) |
0.342 (1.00) |
0.00732 (1.00) |
0.129 (1.00) |
0.765 (1.00) |
0.178 (1.00) |
0.801 (1.00) |
0.555 (1.00) |
0.00472 (1.00) |
0.217 (1.00) |
0.563 (1.00) |
0.0606 (1.00) |
0.237 (1.00) |
P value = 0.00013 (Fisher's exact test), Q value = 0.12
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
AMP PEAK 5(6P21.1) MUTATED | 66 | 41 | 44 |
AMP PEAK 5(6P21.1) WILD-TYPE | 275 | 107 | 68 |
P value = 0.000262 (Wilcoxon-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
AMP PEAK 5(6P21.1) MUTATED | 146 | 3.4 (6.0) |
AMP PEAK 5(6P21.1) WILD-TYPE | 424 | 1.8 (4.1) |
P value = 8e-05 (Fisher's exact test), Q value = 0.072
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
AMP PEAK 6(7P21.3) MUTATED | 56 | 1 | 19 | 77 | 3 | 2 | 15 | 15 | 58 | 38 | 42 | 21 | 1 |
AMP PEAK 6(7P21.3) WILD-TYPE | 46 | 0 | 17 | 94 | 7 | 1 | 11 | 6 | 20 | 15 | 19 | 6 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
AMP PEAK 6(7P21.3) MUTATED | 170 | 107 | 77 |
AMP PEAK 6(7P21.3) WILD-TYPE | 171 | 41 | 35 |
P value = 3.5e-05 (Wilcoxon-test), Q value = 0.032
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
AMP PEAK 6(7P21.3) MUTATED | 339 | 2.6 (5.1) |
AMP PEAK 6(7P21.3) WILD-TYPE | 231 | 1.7 (4.0) |
P value = 3e-05 (Fisher's exact test), Q value = 0.027
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
AMP PEAK 14(13Q12.13) MUTATED | 63 | 0 | 16 | 98 | 4 | 3 | 15 | 17 | 58 | 38 | 50 | 23 | 0 |
AMP PEAK 14(13Q12.13) WILD-TYPE | 39 | 1 | 20 | 73 | 6 | 0 | 11 | 4 | 20 | 15 | 11 | 4 | 2 |
P value = 2e-05 (Fisher's exact test), Q value = 0.018
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
AMP PEAK 14(13Q12.13) MUTATED | 194 | 112 | 85 |
AMP PEAK 14(13Q12.13) WILD-TYPE | 147 | 36 | 27 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 14(13Q12.13) MUTATED | 249 | 17 | 117 | 5 |
AMP PEAK 14(13Q12.13) WILD-TYPE | 129 | 42 | 29 | 8 |
P value = 7.11e-05 (Wilcoxon-test), Q value = 0.064
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
AMP PEAK 14(13Q12.13) MUTATED | 375 | 2.5 (4.9) |
AMP PEAK 14(13Q12.13) WILD-TYPE | 195 | 1.6 (4.2) |
P value = 6e-05 (Fisher's exact test), Q value = 0.054
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
AMP PEAK 15(13Q12.2) MUTATED | 63 | 0 | 16 | 96 | 4 | 3 | 15 | 17 | 58 | 37 | 49 | 22 | 0 |
AMP PEAK 15(13Q12.2) WILD-TYPE | 39 | 1 | 20 | 75 | 6 | 0 | 11 | 4 | 20 | 16 | 12 | 5 | 2 |
P value = 2e-05 (Fisher's exact test), Q value = 0.018
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
AMP PEAK 15(13Q12.2) MUTATED | 192 | 110 | 84 |
AMP PEAK 15(13Q12.2) WILD-TYPE | 149 | 38 | 28 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 15(13Q12.2) MUTATED | 245 | 17 | 116 | 5 |
AMP PEAK 15(13Q12.2) WILD-TYPE | 133 | 42 | 30 | 8 |
P value = 8.9e-05 (Wilcoxon-test), Q value = 0.08
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
AMP PEAK 15(13Q12.2) MUTATED | 371 | 2.5 (4.9) |
AMP PEAK 15(13Q12.2) WILD-TYPE | 199 | 1.6 (4.2) |
P value = 3e-05 (Fisher's exact test), Q value = 0.027
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
AMP PEAK 16(13Q22.1) MUTATED | 194 | 111 | 83 |
AMP PEAK 16(13Q22.1) WILD-TYPE | 147 | 37 | 29 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 16(13Q22.1) MUTATED | 251 | 19 | 112 | 4 |
AMP PEAK 16(13Q22.1) WILD-TYPE | 127 | 40 | 34 | 9 |
P value = 3e-05 (Fisher's exact test), Q value = 0.027
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
AMP PEAK 18(16P11.2) MUTATED | 70 | 55 | 43 |
AMP PEAK 18(16P11.2) WILD-TYPE | 271 | 93 | 69 |
P value = 3.32e-05 (Wilcoxon-test), Q value = 0.03
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
AMP PEAK 18(16P11.2) MUTATED | 161 | 3.1 (5.9) |
AMP PEAK 18(16P11.2) WILD-TYPE | 409 | 1.9 (4.1) |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 24(20P11.21) MUTATED | 221 | 21 | 105 | 4 |
AMP PEAK 24(20P11.21) WILD-TYPE | 157 | 38 | 41 | 9 |
P value = 2.99e-06 (Fisher's exact test), Q value = 0.0028
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
AMP PEAK 25(20Q11.21) MUTATED | 312 | 144 |
AMP PEAK 25(20Q11.21) WILD-TYPE | 126 | 18 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 25(20Q11.21) MUTATED | 286 | 25 | 135 | 7 |
AMP PEAK 25(20Q11.21) WILD-TYPE | 92 | 34 | 11 | 6 |
P value = 1.51e-06 (Fisher's exact test), Q value = 0.0014
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
AMP PEAK 26(20Q12) MUTATED | 313 | 145 |
AMP PEAK 26(20Q12) WILD-TYPE | 125 | 17 |
P value = 0.00024 (Fisher's exact test), Q value = 0.21
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
AMP PEAK 26(20Q12) MUTATED | 77 | 1 | 21 | 118 | 5 | 3 | 18 | 20 | 62 | 44 | 55 | 25 | 1 |
AMP PEAK 26(20Q12) WILD-TYPE | 25 | 0 | 15 | 53 | 5 | 0 | 8 | 1 | 16 | 9 | 6 | 2 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 26(20Q12) MUTATED | 288 | 24 | 136 | 7 |
AMP PEAK 26(20Q12) WILD-TYPE | 90 | 35 | 10 | 6 |
P value = 2.4e-06 (Fisher's exact test), Q value = 0.0023
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
AMP PEAK 27(20Q13.31) MUTATED | 315 | 145 |
AMP PEAK 27(20Q13.31) WILD-TYPE | 123 | 17 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
AMP PEAK 27(20Q13.31) MUTATED | 289 | 25 | 136 | 7 |
AMP PEAK 27(20Q13.31) WILD-TYPE | 89 | 34 | 10 | 6 |
P value = 0.00012 (Fisher's exact test), Q value = 0.11
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 446 | 74 | 10 | 2 | 63 |
DEL PEAK 1(1P36.11) MUTATED | 160 | 46 | 6 | 0 | 24 |
DEL PEAK 1(1P36.11) WILD-TYPE | 286 | 28 | 4 | 2 | 39 |
P value = 3.05e-05 (Fisher's exact test), Q value = 0.028
nPatients | NO | YES |
---|---|---|
ALL | 9 | 595 |
DEL PEAK 9(4P16.2) MUTATED | 9 | 184 |
DEL PEAK 9(4P16.2) WILD-TYPE | 0 | 411 |
P value = 9.72e-05 (Wilcoxon-test), Q value = 0.087
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 9(4P16.2) MUTATED | 185 | 3.2 (5.5) |
DEL PEAK 9(4P16.2) WILD-TYPE | 385 | 1.7 (4.2) |
P value = 0.000108 (Wilcoxon-test), Q value = 0.096
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 10(4Q22.1) MUTATED | 204 | 3.1 (5.5) |
DEL PEAK 10(4Q22.1) WILD-TYPE | 366 | 1.7 (4.1) |
P value = 0.000206 (Wilcoxon-test), Q value = 0.18
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 11(4Q35.1) MUTATED | 213 | 2.9 (4.9) |
DEL PEAK 11(4Q35.1) WILD-TYPE | 357 | 1.8 (4.5) |
P value = 0.000104 (Fisher's exact test), Q value = 0.093
nPatients | NO | YES |
---|---|---|
ALL | 9 | 595 |
DEL PEAK 12(5Q12.1) MUTATED | 8 | 145 |
DEL PEAK 12(5Q12.1) WILD-TYPE | 1 | 450 |
P value = 7.01e-05 (Fisher's exact test), Q value = 0.063
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
DEL PEAK 18(8P23.2) MUTATED | 184 | 98 |
DEL PEAK 18(8P23.2) WILD-TYPE | 254 | 64 |
P value = 5e-05 (Fisher's exact test), Q value = 0.045
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 18(8P23.2) MUTATED | 39 | 0 | 12 | 64 | 3 | 2 | 14 | 11 | 42 | 33 | 44 | 14 | 1 |
DEL PEAK 18(8P23.2) WILD-TYPE | 63 | 1 | 24 | 107 | 7 | 1 | 12 | 10 | 36 | 20 | 17 | 13 | 1 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 18(8P23.2) MUTATED | 131 | 79 | 72 |
DEL PEAK 18(8P23.2) WILD-TYPE | 210 | 69 | 40 |
P value = 7e-05 (Fisher's exact test), Q value = 0.063
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 18(8P23.2) MUTATED | 167 | 16 | 89 | 7 |
DEL PEAK 18(8P23.2) WILD-TYPE | 211 | 43 | 57 | 6 |
P value = 3.56e-06 (Wilcoxon-test), Q value = 0.0033
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 18(8P23.2) MUTATED | 272 | 3.0 (5.8) |
DEL PEAK 18(8P23.2) WILD-TYPE | 298 | 1.5 (3.3) |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 19(8P22) MUTATED | 38 | 0 | 13 | 66 | 3 | 2 | 14 | 13 | 44 | 36 | 44 | 17 | 1 |
DEL PEAK 19(8P22) WILD-TYPE | 64 | 1 | 23 | 105 | 7 | 1 | 12 | 8 | 34 | 17 | 17 | 10 | 1 |
P value = 2e-05 (Fisher's exact test), Q value = 0.018
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 19(8P22) MUTATED | 134 | 82 | 78 |
DEL PEAK 19(8P22) WILD-TYPE | 207 | 66 | 34 |
P value = 1e-04 (Fisher's exact test), Q value = 0.089
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 19(8P22) MUTATED | 178 | 17 | 89 | 7 |
DEL PEAK 19(8P22) WILD-TYPE | 200 | 42 | 57 | 6 |
P value = 4.28e-08 (Wilcoxon-test), Q value = 4.1e-05
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 19(8P22) MUTATED | 285 | 3.1 (5.7) |
DEL PEAK 19(8P22) WILD-TYPE | 285 | 1.4 (3.3) |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 29(14Q11.2) MUTATED | 129 | 5 | 66 | 2 |
DEL PEAK 29(14Q11.2) WILD-TYPE | 249 | 54 | 80 | 11 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 30(14Q31.1) MUTATED | 136 | 5 | 65 | 1 |
DEL PEAK 30(14Q31.1) WILD-TYPE | 242 | 54 | 81 | 12 |
P value = 0.00023 (Fisher's exact test), Q value = 0.2
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 37(17P12) MUTATED | 52 | 0 | 19 | 87 | 3 | 1 | 16 | 16 | 51 | 41 | 45 | 20 | 2 |
DEL PEAK 37(17P12) WILD-TYPE | 50 | 1 | 17 | 84 | 7 | 2 | 10 | 5 | 27 | 12 | 16 | 7 | 0 |
P value = 6e-05 (Fisher's exact test), Q value = 0.054
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 37(17P12) MUTATED | 177 | 101 | 81 |
DEL PEAK 37(17P12) WILD-TYPE | 164 | 47 | 31 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 37(17P12) MUTATED | 227 | 16 | 105 | 6 |
DEL PEAK 37(17P12) WILD-TYPE | 151 | 43 | 41 | 7 |
P value = 9.69e-06 (Wilcoxon-test), Q value = 0.0091
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 37(17P12) MUTATED | 341 | 2.7 (5.2) |
DEL PEAK 37(17P12) WILD-TYPE | 229 | 1.5 (3.8) |
P value = 5.44e-05 (Wilcoxon-test), Q value = 0.049
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 38(17Q24.3) MUTATED | 89 | 3.2 (4.5) |
DEL PEAK 38(17Q24.3) WILD-TYPE | 481 | 2.0 (4.7) |
P value = 2.45e-06 (Fisher's exact test), Q value = 0.0023
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
DEL PEAK 39(18P11.31) MUTATED | 238 | 122 |
DEL PEAK 39(18P11.31) WILD-TYPE | 200 | 40 |
P value = 9e-05 (Fisher's exact test), Q value = 0.08
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 39(18P11.31) MUTATED | 56 | 0 | 14 | 96 | 4 | 3 | 12 | 13 | 51 | 34 | 47 | 24 | 1 |
DEL PEAK 39(18P11.31) WILD-TYPE | 46 | 1 | 22 | 75 | 6 | 0 | 14 | 8 | 27 | 19 | 14 | 3 | 1 |
P value = 3e-05 (Fisher's exact test), Q value = 0.027
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 446 | 74 | 10 | 2 | 63 |
DEL PEAK 39(18P11.31) MUTATED | 253 | 60 | 10 | 1 | 35 |
DEL PEAK 39(18P11.31) WILD-TYPE | 193 | 14 | 0 | 1 | 28 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 39(18P11.31) MUTATED | 227 | 10 | 116 | 6 |
DEL PEAK 39(18P11.31) WILD-TYPE | 151 | 49 | 30 | 7 |
P value = 1.4e-09 (Fisher's exact test), Q value = 1.3e-06
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
DEL PEAK 40(18Q12.2) MUTATED | 266 | 139 |
DEL PEAK 40(18Q12.2) WILD-TYPE | 172 | 23 |
P value = 0.00026 (Fisher's exact test), Q value = 0.23
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 40(18Q12.2) MUTATED | 59 | 0 | 21 | 105 | 4 | 3 | 15 | 17 | 58 | 40 | 52 | 23 | 1 |
DEL PEAK 40(18Q12.2) WILD-TYPE | 43 | 1 | 15 | 66 | 6 | 0 | 11 | 4 | 20 | 13 | 9 | 4 | 1 |
P value = 7e-05 (Fisher's exact test), Q value = 0.063
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 40(18Q12.2) MUTATED | 205 | 114 | 86 |
DEL PEAK 40(18Q12.2) WILD-TYPE | 136 | 34 | 26 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 40(18Q12.2) MUTATED | 250 | 15 | 128 | 10 |
DEL PEAK 40(18Q12.2) WILD-TYPE | 128 | 44 | 18 | 3 |
P value = 0.000195 (Wilcoxon-test), Q value = 0.17
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 40(18Q12.2) MUTATED | 386 | 2.5 (5.0) |
DEL PEAK 40(18Q12.2) WILD-TYPE | 184 | 1.6 (3.9) |
P value = 3.46e-09 (Fisher's exact test), Q value = 3.3e-06
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
DEL PEAK 41(18Q21.2) MUTATED | 280 | 142 |
DEL PEAK 41(18Q21.2) WILD-TYPE | 158 | 20 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 41(18Q21.2) MUTATED | 61 | 0 | 23 | 107 | 4 | 3 | 16 | 17 | 61 | 43 | 55 | 24 | 2 |
DEL PEAK 41(18Q21.2) WILD-TYPE | 41 | 1 | 13 | 64 | 6 | 0 | 10 | 4 | 17 | 10 | 6 | 3 | 0 |
P value = 2e-05 (Fisher's exact test), Q value = 0.018
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 41(18Q21.2) MUTATED | 211 | 118 | 93 |
DEL PEAK 41(18Q21.2) WILD-TYPE | 130 | 30 | 19 |
P value = 0.00013 (Fisher's exact test), Q value = 0.12
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 446 | 74 | 10 | 2 | 63 |
DEL PEAK 41(18Q21.2) MUTATED | 301 | 67 | 9 | 2 | 42 |
DEL PEAK 41(18Q21.2) WILD-TYPE | 145 | 7 | 1 | 0 | 21 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 41(18Q21.2) MUTATED | 262 | 17 | 129 | 11 |
DEL PEAK 41(18Q21.2) WILD-TYPE | 116 | 42 | 17 | 2 |
P value = 1.61e-06 (Wilcoxon-test), Q value = 0.0015
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 41(18Q21.2) MUTATED | 402 | 2.6 (5.0) |
DEL PEAK 41(18Q21.2) WILD-TYPE | 168 | 1.4 (3.9) |
P value = 1.6e-07 (Fisher's exact test), Q value = 0.00015
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
DEL PEAK 42(18Q22.1) MUTATED | 279 | 138 |
DEL PEAK 42(18Q22.1) WILD-TYPE | 159 | 24 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
DEL PEAK 42(18Q22.1) MUTATED | 61 | 0 | 23 | 107 | 4 | 3 | 14 | 16 | 60 | 43 | 54 | 24 | 2 |
DEL PEAK 42(18Q22.1) WILD-TYPE | 41 | 1 | 13 | 64 | 6 | 0 | 12 | 5 | 18 | 10 | 7 | 3 | 0 |
P value = 2e-05 (Fisher's exact test), Q value = 0.018
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 42(18Q22.1) MUTATED | 211 | 114 | 92 |
DEL PEAK 42(18Q22.1) WILD-TYPE | 130 | 34 | 20 |
P value = 0.00027 (Fisher's exact test), Q value = 0.24
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 446 | 74 | 10 | 2 | 63 |
DEL PEAK 42(18Q22.1) MUTATED | 298 | 66 | 9 | 2 | 41 |
DEL PEAK 42(18Q22.1) WILD-TYPE | 148 | 8 | 1 | 0 | 22 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0094
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 42(18Q22.1) MUTATED | 262 | 16 | 127 | 10 |
DEL PEAK 42(18Q22.1) WILD-TYPE | 116 | 43 | 19 | 3 |
P value = 1.54e-05 (Wilcoxon-test), Q value = 0.014
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 42(18Q22.1) MUTATED | 399 | 2.6 (5.0) |
DEL PEAK 42(18Q22.1) WILD-TYPE | 171 | 1.4 (3.8) |
P value = 1e-04 (Fisher's exact test), Q value = 0.089
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 43(19P13.3) MUTATED | 37 | 27 | 31 |
DEL PEAK 43(19P13.3) WILD-TYPE | 304 | 121 | 81 |
P value = 4.71e-06 (Wilcoxon-test), Q value = 0.0044
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 43(19P13.3) MUTATED | 90 | 3.9 (6.0) |
DEL PEAK 43(19P13.3) WILD-TYPE | 480 | 1.9 (4.4) |
P value = 8e-05 (Fisher's exact test), Q value = 0.072
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
DEL PEAK 45(21Q11.2) MUTATED | 126 | 8 | 66 | 3 |
DEL PEAK 45(21Q11.2) WILD-TYPE | 252 | 51 | 80 | 10 |
P value = 0.00028 (Fisher's exact test), Q value = 0.25
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
DEL PEAK 46(22Q13.32) MUTATED | 102 | 70 | 49 |
DEL PEAK 46(22Q13.32) WILD-TYPE | 239 | 78 | 63 |
P value = 0.000266 (Wilcoxon-test), Q value = 0.23
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
DEL PEAK 46(22Q13.32) MUTATED | 210 | 2.9 (5.2) |
DEL PEAK 46(22Q13.32) WILD-TYPE | 360 | 1.8 (4.4) |
-
Copy number data file = transformed.cor.cli.txt
-
Clinical data file = COADREAD-TP.merged_data.txt
-
Number of patients = 604
-
Number of significantly focal cnvs = 73
-
Number of selected clinical features = 13
-
Exclude genes that fewer than K tumors have mutations, K = 3
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary or multi-class clinical features (nominal or ordinal), two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.