This pipeline computes the correlation between cancer subtypes identified by different molecular patterns and selected clinical features.
Testing the association between subtypes identified by 12 different clustering approaches and 13 clinical features across 617 patients, 30 significant findings detected with P value < 0.05 and Q value < 0.25.
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CNMF clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'HISTOLOGICAL.TYPE'.
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Consensus hierarchical clustering analysis on array-based mRNA expression data identified 4 subtypes that correlate to 'HISTOLOGICAL.TYPE'.
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3 subtypes identified in current cancer cohort by 'Copy Number Ratio CNMF subtypes'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE', 'PATHOLOGY.N.STAGE', 'HISTOLOGICAL.TYPE', and 'NUMBER.OF.LYMPH.NODES'.
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3 subtypes identified in current cancer cohort by 'METHLYATION CNMF'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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CNMF clustering analysis on RPPA data identified 4 subtypes that correlate to 'PATHOLOGY.M.STAGE'.
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Consensus hierarchical clustering analysis on RPPA data identified 3 subtypes that correlate to 'PATHOLOGY.M.STAGE' and 'NUMBER.OF.LYMPH.NODES'.
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CNMF clustering analysis on sequencing-based mRNA expression data identified 4 subtypes that correlate to 'PATHOLOGY.M.STAGE', 'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.
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Consensus hierarchical clustering analysis on sequencing-based mRNA expression data identified 7 subtypes that correlate to 'AGE', 'PRIMARY.SITE.OF.DISEASE', 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.M.STAGE', 'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CNMF'. These subtypes correlate to 'NEOPLASM.DISEASESTAGE', 'PATHOLOGY.M.STAGE', 'HISTOLOGICAL.TYPE', and 'COMPLETENESS.OF.RESECTION'.
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3 subtypes identified in current cancer cohort by 'MIRSEQ CHIERARCHICAL'. These subtypes correlate to 'PATHOLOGY.M.STAGE' and 'COMPLETENESS.OF.RESECTION'.
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6 subtypes identified in current cancer cohort by 'MIRseq Mature CNMF subtypes'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
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4 subtypes identified in current cancer cohort by 'MIRseq Mature cHierClus subtypes'. These subtypes correlate to 'PRIMARY.SITE.OF.DISEASE' and 'HISTOLOGICAL.TYPE'.
Clinical Features |
Statistical Tests |
mRNA CNMF subtypes |
mRNA cHierClus subtypes |
Copy Number Ratio CNMF subtypes |
METHLYATION CNMF |
RPPA CNMF subtypes |
RPPA cHierClus subtypes |
RNAseq CNMF subtypes |
RNAseq cHierClus subtypes |
MIRSEQ CNMF |
MIRSEQ CHIERARCHICAL |
MIRseq Mature CNMF subtypes |
MIRseq Mature cHierClus subtypes |
Time to Death | logrank test |
0.2 (1.00) |
0.223 (1.00) |
0.681 (1.00) |
0.945 (1.00) |
0.433 (1.00) |
0.236 (1.00) |
0.065 (1.00) |
0.594 (1.00) |
0.0499 (1.00) |
0.678 (1.00) |
0.588 (1.00) |
0.557 (1.00) |
AGE | Kruskal-Wallis (anova) |
0.434 (1.00) |
0.0483 (1.00) |
0.324 (1.00) |
0.00707 (0.842) |
0.955 (1.00) |
0.65 (1.00) |
0.00232 (0.292) |
0.000335 (0.0432) |
0.00875 (1.00) |
0.00428 (0.526) |
0.201 (1.00) |
0.516 (1.00) |
PRIMARY SITE OF DISEASE | Fisher's exact test |
0.0242 (1.00) |
0.00285 (0.353) |
3e-05 (0.0042) |
0.00031 (0.0403) |
0.828 (1.00) |
0.77 (1.00) |
0.0304 (1.00) |
0.00016 (0.0214) |
0.04 (1.00) |
0.262 (1.00) |
1e-05 (0.00156) |
1e-05 (0.00156) |
NEOPLASM DISEASESTAGE | Fisher's exact test |
0.00542 (0.656) |
0.0505 (1.00) |
0.00451 (0.55) |
0.799 (1.00) |
0.0984 (1.00) |
0.0296 (1.00) |
0.00252 (0.315) |
1e-05 (0.00156) |
0.00012 (0.0162) |
0.0103 (1.00) |
0.196 (1.00) |
0.77 (1.00) |
PATHOLOGY T STAGE | Fisher's exact test |
0.0561 (1.00) |
0.062 (1.00) |
0.606 (1.00) |
0.755 (1.00) |
0.335 (1.00) |
0.0432 (1.00) |
0.0444 (1.00) |
0.293 (1.00) |
0.106 (1.00) |
0.919 (1.00) |
0.143 (1.00) |
0.441 (1.00) |
PATHOLOGY N STAGE | Fisher's exact test |
0.0157 (1.00) |
0.459 (1.00) |
7e-05 (0.00966) |
0.323 (1.00) |
0.0713 (1.00) |
0.0167 (1.00) |
0.134 (1.00) |
0.0106 (1.00) |
0.014 (1.00) |
0.123 (1.00) |
0.183 (1.00) |
0.788 (1.00) |
PATHOLOGY M STAGE | Fisher's exact test |
0.00915 (1.00) |
0.0579 (1.00) |
0.031 (1.00) |
0.884 (1.00) |
0.00105 (0.134) |
0.0001 (0.0136) |
1e-05 (0.00156) |
1e-05 (0.00156) |
1e-05 (0.00156) |
1e-05 (0.00156) |
0.127 (1.00) |
0.491 (1.00) |
GENDER | Fisher's exact test |
0.061 (1.00) |
0.19 (1.00) |
0.322 (1.00) |
0.0789 (1.00) |
0.717 (1.00) |
0.325 (1.00) |
0.492 (1.00) |
0.151 (1.00) |
0.54 (1.00) |
0.517 (1.00) |
0.857 (1.00) |
0.326 (1.00) |
HISTOLOGICAL TYPE | Fisher's exact test |
1e-05 (0.00156) |
1e-05 (0.00156) |
1e-05 (0.00156) |
0.00022 (0.0293) |
0.18 (1.00) |
0.207 (1.00) |
3e-05 (0.0042) |
1e-05 (0.00156) |
0.00024 (0.0317) |
0.341 (1.00) |
1e-05 (0.00156) |
1e-05 (0.00156) |
RADIATIONS RADIATION REGIMENINDICATION | Fisher's exact test |
0.396 (1.00) |
0.654 (1.00) |
0.84 (1.00) |
0.0623 (1.00) |
0.731 (1.00) |
0.0564 (1.00) |
0.428 (1.00) |
0.0277 (1.00) |
0.0952 (1.00) |
0.398 (1.00) |
0.881 (1.00) |
0.144 (1.00) |
COMPLETENESS OF RESECTION | Fisher's exact test |
0.0186 (1.00) |
0.0105 (1.00) |
0.0175 (1.00) |
0.219 (1.00) |
0.0172 (1.00) |
0.0148 (1.00) |
1e-05 (0.00156) |
1e-05 (0.00156) |
1e-05 (0.00156) |
7e-05 (0.00966) |
0.533 (1.00) |
0.355 (1.00) |
NUMBER OF LYMPH NODES | Kruskal-Wallis (anova) |
0.0127 (1.00) |
0.174 (1.00) |
0.00127 (0.162) |
0.681 (1.00) |
0.0256 (1.00) |
0.000274 (0.0359) |
0.0693 (1.00) |
0.00627 (0.753) |
0.0488 (1.00) |
0.127 (1.00) |
0.0318 (1.00) |
0.348 (1.00) |
RACE | Fisher's exact test |
0.134 (1.00) |
0.168 (1.00) |
0.797 (1.00) |
0.756 (1.00) |
0.0465 (1.00) |
0.76 (1.00) |
0.699 (1.00) |
0.425 (1.00) |
0.659 (1.00) |
0.792 (1.00) |
0.218 (1.00) |
0.793 (1.00) |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 46 | 62 | 72 | 42 |
P value = 0.2 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 203 | 36 | 0.9 - 54.0 (21.0) |
subtype1 | 40 | 8 | 0.9 - 46.6 (22.7) |
subtype2 | 58 | 15 | 1.0 - 52.0 (20.0) |
subtype3 | 66 | 8 | 0.9 - 50.0 (20.5) |
subtype4 | 39 | 5 | 1.0 - 54.0 (21.0) |
P value = 0.434 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 69.5 (11.4) |
subtype1 | 46 | 70.8 (11.8) |
subtype2 | 62 | 68.5 (8.9) |
subtype3 | 72 | 69.5 (12.4) |
subtype4 | 42 | 69.6 (12.6) |
P value = 0.0242 (Fisher's exact test), Q value = 1
nPatients | COLON | RECTUM |
---|---|---|
ALL | 152 | 68 |
subtype1 | 39 | 7 |
subtype2 | 37 | 25 |
subtype3 | 45 | 25 |
subtype4 | 31 | 11 |
P value = 0.00542 (Fisher's exact test), Q value = 0.66
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 47 | 15 | 65 | 5 | 10 | 3 | 22 | 20 | 33 | 1 |
subtype1 | 8 | 3 | 15 | 3 | 3 | 1 | 4 | 2 | 6 | 0 |
subtype2 | 9 | 2 | 14 | 0 | 2 | 2 | 5 | 11 | 17 | 0 |
subtype3 | 19 | 4 | 23 | 0 | 4 | 0 | 7 | 7 | 8 | 0 |
subtype4 | 11 | 6 | 13 | 2 | 1 | 0 | 6 | 0 | 2 | 1 |
P value = 0.0561 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 9 | 46 | 148 | 19 |
subtype1 | 1 | 9 | 30 | 6 |
subtype2 | 1 | 12 | 41 | 8 |
subtype3 | 5 | 16 | 51 | 0 |
subtype4 | 2 | 9 | 26 | 5 |
P value = 0.0157 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 136 | 43 | 43 |
subtype1 | 30 | 6 | 10 |
subtype2 | 28 | 17 | 17 |
subtype3 | 46 | 12 | 14 |
subtype4 | 32 | 8 | 2 |
P value = 0.00915 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | M1A |
---|---|---|---|
ALL | 186 | 33 | 1 |
subtype1 | 39 | 6 | 0 |
subtype2 | 45 | 17 | 0 |
subtype3 | 63 | 8 | 0 |
subtype4 | 39 | 2 | 1 |
P value = 0.061 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 106 | 116 |
subtype1 | 28 | 18 |
subtype2 | 33 | 29 |
subtype3 | 30 | 42 |
subtype4 | 15 | 27 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 129 | 22 | 58 | 7 |
subtype1 | 28 | 11 | 4 | 2 |
subtype2 | 36 | 1 | 25 | 0 |
subtype3 | 44 | 1 | 21 | 2 |
subtype4 | 21 | 9 | 8 | 3 |
P value = 0.396 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 1 | 221 |
subtype1 | 1 | 45 |
subtype2 | 0 | 62 |
subtype3 | 0 | 72 |
subtype4 | 0 | 42 |
P value = 0.0186 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 |
---|---|---|---|
ALL | 185 | 2 | 29 |
subtype1 | 38 | 0 | 4 |
subtype2 | 45 | 2 | 15 |
subtype3 | 62 | 0 | 8 |
subtype4 | 40 | 0 | 2 |
P value = 0.0127 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 221 | 2.2 (4.7) |
subtype1 | 46 | 3.3 (7.0) |
subtype2 | 62 | 2.9 (5.4) |
subtype3 | 72 | 1.6 (2.7) |
subtype4 | 41 | 0.8 (2.2) |
P value = 0.134 (Fisher's exact test), Q value = 1
nPatients | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|
ALL | 2 | 15 |
subtype1 | 0 | 7 |
subtype2 | 2 | 3 |
subtype3 | 0 | 4 |
subtype4 | 0 | 1 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 52 | 41 | 77 | 52 |
P value = 0.223 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 203 | 36 | 0.9 - 54.0 (21.0) |
subtype1 | 46 | 9 | 0.9 - 53.0 (22.5) |
subtype2 | 39 | 11 | 1.0 - 48.0 (17.8) |
subtype3 | 71 | 11 | 1.0 - 54.0 (20.0) |
subtype4 | 47 | 5 | 0.9 - 50.0 (21.0) |
P value = 0.0483 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 222 | 69.5 (11.4) |
subtype1 | 52 | 72.9 (11.6) |
subtype2 | 41 | 67.7 (9.6) |
subtype3 | 77 | 68.1 (11.7) |
subtype4 | 52 | 69.5 (11.6) |
P value = 0.00285 (Fisher's exact test), Q value = 0.35
nPatients | COLON | RECTUM |
---|---|---|
ALL | 152 | 68 |
subtype1 | 46 | 6 |
subtype2 | 24 | 17 |
subtype3 | 48 | 28 |
subtype4 | 34 | 17 |
P value = 0.0505 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|
ALL | 47 | 15 | 65 | 5 | 10 | 3 | 22 | 20 | 33 | 1 |
subtype1 | 9 | 3 | 17 | 4 | 3 | 1 | 6 | 2 | 5 | 1 |
subtype2 | 4 | 2 | 10 | 1 | 0 | 1 | 4 | 7 | 12 | 0 |
subtype3 | 20 | 8 | 23 | 0 | 6 | 1 | 5 | 5 | 9 | 0 |
subtype4 | 14 | 2 | 15 | 0 | 1 | 0 | 7 | 6 | 7 | 0 |
P value = 0.062 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 9 | 46 | 148 | 19 |
subtype1 | 1 | 10 | 33 | 8 |
subtype2 | 0 | 7 | 28 | 6 |
subtype3 | 7 | 15 | 51 | 4 |
subtype4 | 1 | 14 | 36 | 1 |
P value = 0.459 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 136 | 43 | 43 |
subtype1 | 34 | 9 | 9 |
subtype2 | 19 | 11 | 11 |
subtype3 | 52 | 12 | 13 |
subtype4 | 31 | 11 | 10 |
P value = 0.0579 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | M1A |
---|---|---|---|
ALL | 186 | 33 | 1 |
subtype1 | 45 | 5 | 1 |
subtype2 | 29 | 12 | 0 |
subtype3 | 68 | 9 | 0 |
subtype4 | 44 | 7 | 0 |
P value = 0.19 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 106 | 116 |
subtype1 | 30 | 22 |
subtype2 | 22 | 19 |
subtype3 | 34 | 43 |
subtype4 | 20 | 32 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 129 | 22 | 58 | 7 |
subtype1 | 27 | 18 | 2 | 3 |
subtype2 | 24 | 0 | 17 | 0 |
subtype3 | 44 | 4 | 23 | 3 |
subtype4 | 34 | 0 | 16 | 1 |
P value = 0.654 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 1 | 221 |
subtype1 | 1 | 51 |
subtype2 | 0 | 41 |
subtype3 | 0 | 77 |
subtype4 | 0 | 52 |
P value = 0.0105 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 |
---|---|---|---|
ALL | 185 | 2 | 29 |
subtype1 | 45 | 0 | 3 |
subtype2 | 28 | 2 | 11 |
subtype3 | 69 | 0 | 8 |
subtype4 | 43 | 0 | 7 |
P value = 0.174 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 221 | 2.2 (4.7) |
subtype1 | 52 | 2.8 (6.4) |
subtype2 | 41 | 3.3 (6.4) |
subtype3 | 76 | 1.5 (2.9) |
subtype4 | 52 | 1.6 (2.6) |
P value = 0.168 (Fisher's exact test), Q value = 1
nPatients | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|
ALL | 2 | 15 |
subtype1 | 0 | 6 |
subtype2 | 2 | 3 |
subtype3 | 0 | 5 |
subtype4 | 0 | 1 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 250 | 203 | 151 |
P value = 0.681 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 575 | 109 | 0.1 - 140.4 (17.8) |
subtype1 | 238 | 49 | 0.1 - 140.4 (17.9) |
subtype2 | 193 | 31 | 0.1 - 131.5 (17.0) |
subtype3 | 144 | 29 | 0.2 - 130.7 (19.0) |
P value = 0.324 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 602 | 66.3 (12.7) |
subtype1 | 248 | 66.9 (14.1) |
subtype2 | 203 | 66.0 (11.2) |
subtype3 | 151 | 65.7 (12.4) |
P value = 3e-05 (Fisher's exact test), Q value = 0.0042
nPatients | COLON | RECTUM |
---|---|---|
ALL | 438 | 162 |
subtype1 | 207 | 43 |
subtype2 | 128 | 71 |
subtype3 | 103 | 48 |
P value = 0.00451 (Fisher's exact test), Q value = 0.55
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 36 | 171 | 10 | 3 | 26 | 21 | 78 | 53 | 61 | 27 | 2 |
subtype1 | 52 | 1 | 18 | 82 | 6 | 0 | 11 | 7 | 26 | 18 | 15 | 7 | 1 |
subtype2 | 32 | 0 | 5 | 54 | 3 | 1 | 9 | 7 | 33 | 14 | 26 | 13 | 1 |
subtype3 | 18 | 0 | 13 | 35 | 1 | 2 | 6 | 7 | 19 | 21 | 20 | 7 | 0 |
P value = 0.606 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 105 | 412 | 65 |
subtype1 | 10 | 49 | 162 | 28 |
subtype2 | 8 | 32 | 141 | 21 |
subtype3 | 2 | 24 | 109 | 16 |
P value = 7e-05 (Fisher's exact test), Q value = 0.0097
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 148 | 112 |
subtype1 | 166 | 48 | 36 |
subtype2 | 102 | 65 | 34 |
subtype3 | 73 | 35 | 42 |
P value = 0.031 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 446 | 74 | 10 | 2 | 63 |
subtype1 | 196 | 18 | 2 | 1 | 29 |
subtype2 | 143 | 34 | 4 | 1 | 17 |
subtype3 | 107 | 22 | 4 | 0 | 17 |
P value = 0.322 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 283 | 321 |
subtype1 | 125 | 125 |
subtype2 | 87 | 116 |
subtype3 | 71 | 80 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 378 | 59 | 146 | 13 |
subtype1 | 160 | 46 | 33 | 9 |
subtype2 | 123 | 5 | 71 | 0 |
subtype3 | 95 | 8 | 42 | 4 |
P value = 0.84 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 9 | 595 |
subtype1 | 3 | 247 |
subtype2 | 3 | 200 |
subtype3 | 3 | 148 |
P value = 0.0175 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 436 | 5 | 36 | 29 |
subtype1 | 183 | 3 | 8 | 17 |
subtype2 | 152 | 0 | 13 | 6 |
subtype3 | 101 | 2 | 15 | 6 |
P value = 0.00127 (Kruskal-Wallis (anova)), Q value = 0.16
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 570 | 2.2 (4.7) |
subtype1 | 234 | 1.8 (4.2) |
subtype2 | 193 | 2.0 (3.4) |
subtype3 | 143 | 3.3 (6.5) |
P value = 0.797 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 56 | 292 |
subtype1 | 1 | 7 | 23 | 127 |
subtype2 | 0 | 2 | 21 | 93 |
subtype3 | 0 | 3 | 12 | 72 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 98 | 158 | 120 |
P value = 0.945 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 367 | 72 | 0.1 - 140.4 (16.2) |
subtype1 | 97 | 16 | 0.1 - 102.4 (15.0) |
subtype2 | 155 | 33 | 0.1 - 139.2 (17.0) |
subtype3 | 115 | 23 | 0.1 - 140.4 (17.1) |
P value = 0.00707 (Kruskal-Wallis (anova)), Q value = 0.84
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 375 | 64.5 (12.9) |
subtype1 | 97 | 61.2 (13.1) |
subtype2 | 158 | 64.7 (12.5) |
subtype3 | 120 | 66.8 (12.9) |
P value = 0.00031 (Fisher's exact test), Q value = 0.04
nPatients | COLON | RECTUM |
---|---|---|
ALL | 278 | 96 |
subtype1 | 68 | 28 |
subtype2 | 106 | 52 |
subtype3 | 104 | 16 |
P value = 0.799 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 52 | 1 | 20 | 109 | 7 | 3 | 11 | 18 | 56 | 34 | 26 | 25 | 1 |
subtype1 | 13 | 0 | 5 | 29 | 1 | 0 | 1 | 7 | 13 | 11 | 6 | 7 | 0 |
subtype2 | 18 | 0 | 9 | 42 | 2 | 2 | 5 | 9 | 28 | 13 | 12 | 12 | 0 |
subtype3 | 21 | 1 | 6 | 38 | 4 | 1 | 5 | 2 | 15 | 10 | 8 | 6 | 1 |
P value = 0.755 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 55 | 262 | 46 |
subtype1 | 3 | 11 | 68 | 15 |
subtype2 | 5 | 22 | 114 | 17 |
subtype3 | 3 | 22 | 80 | 14 |
P value = 0.323 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 206 | 100 | 66 |
subtype1 | 52 | 28 | 17 |
subtype2 | 80 | 48 | 27 |
subtype3 | 74 | 24 | 22 |
P value = 0.884 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 260 | 38 | 9 | 1 | 61 |
subtype1 | 70 | 9 | 2 | 0 | 14 |
subtype2 | 105 | 19 | 5 | 0 | 28 |
subtype3 | 85 | 10 | 2 | 1 | 19 |
P value = 0.0789 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 170 | 206 |
subtype1 | 38 | 60 |
subtype2 | 68 | 90 |
subtype3 | 64 | 56 |
P value = 0.00022 (Fisher's exact test), Q value = 0.029
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 244 | 34 | 90 | 6 |
subtype1 | 56 | 12 | 27 | 1 |
subtype2 | 100 | 6 | 49 | 3 |
subtype3 | 88 | 16 | 14 | 2 |
P value = 0.0623 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 8 | 368 |
subtype1 | 4 | 94 |
subtype2 | 4 | 154 |
subtype3 | 0 | 120 |
P value = 0.219 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 245 | 4 | 6 | 28 |
subtype1 | 67 | 1 | 0 | 4 |
subtype2 | 103 | 1 | 2 | 11 |
subtype3 | 75 | 2 | 4 | 13 |
P value = 0.681 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 342 | 2.2 (4.8) |
subtype1 | 89 | 2.6 (5.1) |
subtype2 | 145 | 2.3 (5.3) |
subtype3 | 108 | 1.9 (3.7) |
P value = 0.756 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 48 | 282 |
subtype1 | 1 | 4 | 11 | 78 |
subtype2 | 0 | 4 | 19 | 118 |
subtype3 | 0 | 4 | 18 | 86 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 100 | 179 | 42 | 140 |
P value = 0.433 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 439 | 87 | 0.1 - 140.4 (18.2) |
subtype1 | 92 | 19 | 0.2 - 117.1 (17.1) |
subtype2 | 168 | 39 | 0.1 - 140.4 (18.3) |
subtype3 | 42 | 5 | 0.1 - 62.0 (19.0) |
subtype4 | 137 | 24 | 0.1 - 135.7 (19.7) |
P value = 0.955 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 460 | 66.8 (12.6) |
subtype1 | 100 | 67.0 (12.7) |
subtype2 | 178 | 67.1 (12.5) |
subtype3 | 42 | 67.4 (10.6) |
subtype4 | 140 | 66.1 (13.5) |
P value = 0.828 (Fisher's exact test), Q value = 1
nPatients | COLON | RECTUM |
---|---|---|
ALL | 331 | 130 |
subtype1 | 70 | 30 |
subtype2 | 126 | 53 |
subtype3 | 32 | 10 |
subtype4 | 103 | 37 |
P value = 0.0984 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 70 | 1 | 27 | 139 | 9 | 2 | 24 | 16 | 62 | 39 | 44 | 19 | 1 |
subtype1 | 10 | 0 | 8 | 26 | 3 | 0 | 3 | 4 | 18 | 10 | 10 | 7 | 0 |
subtype2 | 27 | 0 | 11 | 44 | 4 | 1 | 11 | 7 | 27 | 10 | 26 | 7 | 1 |
subtype3 | 8 | 1 | 3 | 17 | 0 | 0 | 2 | 0 | 3 | 5 | 1 | 1 | 0 |
subtype4 | 25 | 0 | 5 | 52 | 2 | 1 | 8 | 5 | 14 | 14 | 7 | 4 | 0 |
P value = 0.335 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 76 | 324 | 48 |
subtype1 | 0 | 13 | 72 | 14 |
subtype2 | 6 | 31 | 123 | 19 |
subtype3 | 0 | 8 | 32 | 1 |
subtype4 | 5 | 24 | 97 | 14 |
P value = 0.0713 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 260 | 117 | 81 |
subtype1 | 47 | 33 | 19 |
subtype2 | 95 | 50 | 34 |
subtype3 | 29 | 6 | 6 |
subtype4 | 89 | 28 | 22 |
P value = 0.00105 (Fisher's exact test), Q value = 0.13
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 357 | 54 | 8 | 1 | 36 |
subtype1 | 78 | 12 | 5 | 0 | 3 |
subtype2 | 130 | 32 | 0 | 1 | 15 |
subtype3 | 37 | 2 | 0 | 0 | 3 |
subtype4 | 112 | 8 | 3 | 0 | 15 |
P value = 0.717 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 215 | 246 |
subtype1 | 42 | 58 |
subtype2 | 88 | 91 |
subtype3 | 19 | 23 |
subtype4 | 66 | 74 |
P value = 0.18 (Fisher's exact test), Q value = 1
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 293 | 38 | 117 | 10 |
subtype1 | 61 | 9 | 24 | 4 |
subtype2 | 119 | 7 | 48 | 4 |
subtype3 | 27 | 5 | 9 | 1 |
subtype4 | 86 | 17 | 36 | 1 |
P value = 0.731 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 8 | 453 |
subtype1 | 3 | 97 |
subtype2 | 3 | 176 |
subtype3 | 0 | 42 |
subtype4 | 2 | 138 |
P value = 0.0172 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 338 | 2 | 28 | 19 |
subtype1 | 74 | 0 | 7 | 7 |
subtype2 | 114 | 1 | 18 | 6 |
subtype3 | 38 | 0 | 1 | 1 |
subtype4 | 112 | 1 | 2 | 5 |
P value = 0.0256 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 435 | 2.1 (4.6) |
subtype1 | 93 | 2.3 (3.8) |
subtype2 | 169 | 2.3 (4.4) |
subtype3 | 41 | 1.5 (3.1) |
subtype4 | 132 | 2.0 (5.6) |
P value = 0.0465 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 24 | 246 |
subtype1 | 0 | 6 | 8 | 45 |
subtype2 | 0 | 5 | 8 | 88 |
subtype3 | 0 | 0 | 2 | 12 |
subtype4 | 1 | 1 | 6 | 101 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 54 | 307 | 100 |
P value = 0.236 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 439 | 87 | 0.1 - 140.4 (18.2) |
subtype1 | 53 | 8 | 0.1 - 130.7 (17.0) |
subtype2 | 288 | 65 | 0.1 - 140.4 (18.1) |
subtype3 | 98 | 14 | 0.1 - 135.7 (19.8) |
P value = 0.65 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 460 | 66.8 (12.6) |
subtype1 | 54 | 66.5 (11.9) |
subtype2 | 306 | 67.1 (12.6) |
subtype3 | 100 | 65.8 (13.2) |
P value = 0.77 (Fisher's exact test), Q value = 1
nPatients | COLON | RECTUM |
---|---|---|
ALL | 331 | 130 |
subtype1 | 39 | 15 |
subtype2 | 223 | 84 |
subtype3 | 69 | 31 |
P value = 0.0296 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 70 | 1 | 27 | 139 | 9 | 2 | 24 | 16 | 62 | 39 | 44 | 19 | 1 |
subtype1 | 6 | 0 | 1 | 15 | 1 | 0 | 1 | 3 | 10 | 5 | 4 | 8 | 0 |
subtype2 | 40 | 1 | 22 | 90 | 7 | 1 | 19 | 8 | 41 | 27 | 36 | 8 | 1 |
subtype3 | 24 | 0 | 4 | 34 | 1 | 1 | 4 | 5 | 11 | 7 | 4 | 3 | 0 |
P value = 0.0432 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 11 | 76 | 324 | 48 |
subtype1 | 0 | 7 | 36 | 11 |
subtype2 | 7 | 45 | 223 | 30 |
subtype3 | 4 | 24 | 65 | 7 |
P value = 0.0167 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 260 | 117 | 81 |
subtype1 | 23 | 17 | 14 |
subtype2 | 168 | 82 | 55 |
subtype3 | 69 | 18 | 12 |
P value = 1e-04 (Fisher's exact test), Q value = 0.014
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 357 | 54 | 8 | 1 | 36 |
subtype1 | 37 | 7 | 5 | 0 | 4 |
subtype2 | 239 | 43 | 0 | 1 | 21 |
subtype3 | 81 | 4 | 3 | 0 | 11 |
P value = 0.325 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 215 | 246 |
subtype1 | 26 | 28 |
subtype2 | 149 | 158 |
subtype3 | 40 | 60 |
P value = 0.207 (Fisher's exact test), Q value = 1
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 293 | 38 | 117 | 10 |
subtype1 | 33 | 6 | 13 | 2 |
subtype2 | 202 | 21 | 73 | 8 |
subtype3 | 58 | 11 | 31 | 0 |
P value = 0.0564 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 8 | 453 |
subtype1 | 3 | 51 |
subtype2 | 3 | 304 |
subtype3 | 2 | 98 |
P value = 0.0148 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 338 | 2 | 28 | 19 |
subtype1 | 44 | 1 | 1 | 1 |
subtype2 | 212 | 1 | 26 | 14 |
subtype3 | 82 | 0 | 1 | 4 |
P value = 0.000274 (Kruskal-Wallis (anova)), Q value = 0.036
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 435 | 2.1 (4.6) |
subtype1 | 51 | 3.9 (8.1) |
subtype2 | 290 | 2.0 (3.9) |
subtype3 | 94 | 1.3 (3.6) |
P value = 0.76 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 24 | 246 |
subtype1 | 0 | 2 | 3 | 39 |
subtype2 | 1 | 9 | 15 | 137 |
subtype3 | 0 | 1 | 6 | 70 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 139 | 131 | 135 | 196 |
P value = 0.065 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 572 | 109 | 0.1 - 140.4 (18.0) |
subtype1 | 134 | 33 | 0.1 - 140.4 (17.1) |
subtype2 | 127 | 29 | 0.1 - 131.5 (13.6) |
subtype3 | 127 | 20 | 0.5 - 135.7 (19.0) |
subtype4 | 184 | 27 | 0.9 - 117.1 (20.5) |
P value = 0.00232 (Kruskal-Wallis (anova)), Q value = 0.29
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 600 | 66.5 (12.6) |
subtype1 | 139 | 63.6 (12.4) |
subtype2 | 131 | 65.7 (13.0) |
subtype3 | 134 | 67.0 (13.0) |
subtype4 | 196 | 68.7 (12.0) |
P value = 0.0304 (Fisher's exact test), Q value = 1
nPatients | COLON | RECTUM |
---|---|---|
ALL | 437 | 160 |
subtype1 | 93 | 46 |
subtype2 | 103 | 28 |
subtype3 | 106 | 27 |
subtype4 | 135 | 59 |
P value = 0.00252 (Fisher's exact test), Q value = 0.31
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 35 | 171 | 11 | 3 | 27 | 21 | 78 | 52 | 59 | 26 | 1 |
subtype1 | 24 | 0 | 7 | 31 | 2 | 2 | 4 | 5 | 23 | 10 | 13 | 11 | 0 |
subtype2 | 12 | 0 | 5 | 44 | 2 | 0 | 2 | 5 | 18 | 18 | 14 | 7 | 0 |
subtype3 | 28 | 1 | 10 | 42 | 2 | 1 | 8 | 6 | 15 | 5 | 7 | 7 | 1 |
subtype4 | 38 | 0 | 13 | 54 | 5 | 0 | 13 | 5 | 22 | 19 | 25 | 1 | 0 |
P value = 0.0444 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 105 | 409 | 65 |
subtype1 | 6 | 28 | 89 | 15 |
subtype2 | 1 | 13 | 95 | 22 |
subtype3 | 4 | 28 | 90 | 12 |
subtype4 | 9 | 36 | 135 | 16 |
P value = 0.134 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 147 | 109 |
subtype1 | 78 | 38 | 20 |
subtype2 | 64 | 34 | 32 |
subtype3 | 87 | 30 | 18 |
subtype4 | 112 | 45 | 39 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 449 | 71 | 10 | 1 | 61 |
subtype1 | 91 | 18 | 6 | 0 | 22 |
subtype2 | 91 | 17 | 3 | 0 | 17 |
subtype3 | 100 | 11 | 0 | 1 | 22 |
subtype4 | 167 | 25 | 1 | 0 | 0 |
P value = 0.492 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 279 | 322 |
subtype1 | 63 | 76 |
subtype2 | 55 | 76 |
subtype3 | 62 | 73 |
subtype4 | 99 | 97 |
P value = 3e-05 (Fisher's exact test), Q value = 0.0042
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 379 | 57 | 144 | 13 |
subtype1 | 90 | 3 | 46 | 0 |
subtype2 | 86 | 17 | 25 | 3 |
subtype3 | 85 | 20 | 20 | 6 |
subtype4 | 118 | 17 | 53 | 4 |
P value = 0.428 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 9 | 592 |
subtype1 | 2 | 137 |
subtype2 | 3 | 128 |
subtype3 | 3 | 132 |
subtype4 | 1 | 195 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 434 | 5 | 35 | 28 |
subtype1 | 79 | 2 | 7 | 10 |
subtype2 | 96 | 1 | 3 | 9 |
subtype3 | 91 | 1 | 3 | 9 |
subtype4 | 168 | 1 | 22 | 0 |
P value = 0.0693 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 566 | 2.2 (4.7) |
subtype1 | 125 | 1.7 (2.9) |
subtype2 | 121 | 3.0 (6.3) |
subtype3 | 126 | 1.8 (4.1) |
subtype4 | 194 | 2.3 (4.9) |
P value = 0.699 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 47 | 294 |
subtype1 | 0 | 4 | 12 | 98 |
subtype2 | 1 | 4 | 14 | 104 |
subtype3 | 0 | 4 | 17 | 72 |
subtype4 | 0 | 0 | 4 | 20 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
---|---|---|---|---|---|---|---|
Number of samples | 79 | 121 | 96 | 63 | 153 | 39 | 50 |
P value = 0.594 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 572 | 109 | 0.1 - 140.4 (18.0) |
subtype1 | 77 | 20 | 0.1 - 140.4 (15.8) |
subtype2 | 116 | 16 | 0.1 - 124.3 (16.3) |
subtype3 | 96 | 21 | 0.3 - 129.3 (14.9) |
subtype4 | 61 | 14 | 0.1 - 135.7 (17.9) |
subtype5 | 141 | 23 | 0.9 - 117.1 (20.0) |
subtype6 | 34 | 5 | 0.9 - 54.0 (20.0) |
subtype7 | 47 | 10 | 0.9 - 62.0 (27.0) |
P value = 0.000335 (Kruskal-Wallis (anova)), Q value = 0.043
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 600 | 66.5 (12.6) |
subtype1 | 79 | 64.9 (12.9) |
subtype2 | 121 | 64.8 (12.9) |
subtype3 | 96 | 64.0 (11.9) |
subtype4 | 62 | 65.2 (15.1) |
subtype5 | 153 | 68.2 (11.0) |
subtype6 | 39 | 73.8 (12.0) |
subtype7 | 50 | 68.7 (12.3) |
P value = 0.00016 (Fisher's exact test), Q value = 0.021
nPatients | COLON | RECTUM |
---|---|---|
ALL | 437 | 160 |
subtype1 | 57 | 22 |
subtype2 | 87 | 32 |
subtype3 | 64 | 32 |
subtype4 | 59 | 4 |
subtype5 | 100 | 51 |
subtype6 | 34 | 5 |
subtype7 | 36 | 14 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 102 | 1 | 35 | 171 | 11 | 3 | 27 | 21 | 78 | 52 | 59 | 26 | 1 |
subtype1 | 14 | 0 | 0 | 25 | 1 | 1 | 0 | 4 | 12 | 9 | 5 | 5 | 0 |
subtype2 | 20 | 1 | 8 | 25 | 2 | 1 | 7 | 8 | 21 | 6 | 9 | 9 | 0 |
subtype3 | 8 | 0 | 4 | 26 | 1 | 1 | 2 | 3 | 16 | 12 | 9 | 10 | 0 |
subtype4 | 13 | 0 | 4 | 28 | 1 | 0 | 2 | 1 | 4 | 5 | 1 | 1 | 1 |
subtype5 | 32 | 0 | 7 | 39 | 1 | 0 | 9 | 5 | 16 | 16 | 27 | 1 | 0 |
subtype6 | 4 | 0 | 4 | 14 | 3 | 0 | 5 | 0 | 5 | 1 | 3 | 0 | 0 |
subtype7 | 11 | 0 | 8 | 14 | 2 | 0 | 2 | 0 | 4 | 3 | 5 | 0 | 0 |
P value = 0.293 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 105 | 409 | 65 |
subtype1 | 1 | 15 | 54 | 9 |
subtype2 | 7 | 20 | 77 | 16 |
subtype3 | 0 | 12 | 70 | 13 |
subtype4 | 2 | 11 | 44 | 6 |
subtype5 | 6 | 35 | 100 | 12 |
subtype6 | 1 | 3 | 29 | 6 |
subtype7 | 3 | 9 | 35 | 3 |
P value = 0.0106 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 341 | 147 | 109 |
subtype1 | 44 | 18 | 16 |
subtype2 | 66 | 39 | 15 |
subtype3 | 41 | 30 | 23 |
subtype4 | 46 | 9 | 8 |
subtype5 | 83 | 37 | 33 |
subtype6 | 25 | 7 | 7 |
subtype7 | 36 | 7 | 7 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 449 | 71 | 10 | 1 | 61 |
subtype1 | 55 | 8 | 2 | 0 | 13 |
subtype2 | 81 | 12 | 2 | 0 | 26 |
subtype3 | 62 | 14 | 5 | 0 | 14 |
subtype4 | 48 | 2 | 0 | 1 | 8 |
subtype5 | 123 | 27 | 1 | 0 | 0 |
subtype6 | 36 | 3 | 0 | 0 | 0 |
subtype7 | 44 | 5 | 0 | 0 | 0 |
P value = 0.151 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 279 | 322 |
subtype1 | 36 | 43 |
subtype2 | 53 | 68 |
subtype3 | 43 | 53 |
subtype4 | 26 | 37 |
subtype5 | 72 | 81 |
subtype6 | 27 | 12 |
subtype7 | 22 | 28 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 379 | 57 | 144 | 13 |
subtype1 | 54 | 3 | 22 | 0 |
subtype2 | 75 | 12 | 29 | 3 |
subtype3 | 58 | 6 | 31 | 1 |
subtype4 | 47 | 12 | 3 | 1 |
subtype5 | 98 | 2 | 49 | 1 |
subtype6 | 21 | 13 | 2 | 2 |
subtype7 | 26 | 9 | 8 | 5 |
P value = 0.0277 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 9 | 592 |
subtype1 | 0 | 79 |
subtype2 | 2 | 119 |
subtype3 | 5 | 91 |
subtype4 | 1 | 62 |
subtype5 | 0 | 153 |
subtype6 | 1 | 38 |
subtype7 | 0 | 50 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 434 | 5 | 35 | 28 |
subtype1 | 43 | 0 | 2 | 8 |
subtype2 | 77 | 2 | 3 | 6 |
subtype3 | 69 | 0 | 0 | 6 |
subtype4 | 41 | 1 | 0 | 8 |
subtype5 | 126 | 2 | 24 | 0 |
subtype6 | 35 | 0 | 1 | 0 |
subtype7 | 43 | 0 | 5 | 0 |
P value = 0.00627 (Kruskal-Wallis (anova)), Q value = 0.75
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 566 | 2.2 (4.7) |
subtype1 | 71 | 2.2 (3.2) |
subtype2 | 111 | 2.1 (4.9) |
subtype3 | 88 | 2.9 (6.2) |
subtype4 | 56 | 1.3 (3.1) |
subtype5 | 151 | 2.3 (4.5) |
subtype6 | 39 | 2.6 (6.3) |
subtype7 | 50 | 1.5 (4.1) |
P value = 0.425 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 47 | 294 |
subtype1 | 0 | 3 | 12 | 60 |
subtype2 | 0 | 1 | 17 | 80 |
subtype3 | 1 | 4 | 8 | 80 |
subtype4 | 0 | 4 | 5 | 51 |
subtype5 | 0 | 0 | 4 | 14 |
subtype6 | 0 | 0 | 0 | 6 |
subtype7 | 0 | 0 | 1 | 3 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 212 | 96 | 241 |
P value = 0.0499 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 520 | 102 | 0.1 - 140.4 (19.1) |
subtype1 | 205 | 40 | 0.1 - 140.4 (17.8) |
subtype2 | 95 | 22 | 0.1 - 100.0 (13.6) |
subtype3 | 220 | 40 | 0.9 - 117.1 (21.0) |
P value = 0.00875 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 548 | 66.8 (12.7) |
subtype1 | 211 | 65.9 (12.5) |
subtype2 | 96 | 64.0 (13.8) |
subtype3 | 241 | 68.8 (12.1) |
P value = 0.04 (Fisher's exact test), Q value = 1
nPatients | COLON | RECTUM |
---|---|---|
ALL | 405 | 140 |
subtype1 | 150 | 61 |
subtype2 | 80 | 15 |
subtype3 | 175 | 64 |
P value = 0.00012 (Fisher's exact test), Q value = 0.016
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 94 | 1 | 36 | 154 | 10 | 2 | 27 | 16 | 69 | 45 | 57 | 23 | 1 |
subtype1 | 32 | 1 | 8 | 67 | 4 | 2 | 8 | 9 | 33 | 13 | 16 | 11 | 1 |
subtype2 | 9 | 0 | 5 | 26 | 0 | 0 | 3 | 3 | 15 | 14 | 7 | 8 | 0 |
subtype3 | 53 | 0 | 23 | 61 | 6 | 0 | 16 | 4 | 21 | 18 | 34 | 4 | 0 |
P value = 0.106 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 95 | 376 | 56 |
subtype1 | 8 | 33 | 151 | 18 |
subtype2 | 2 | 10 | 69 | 15 |
subtype3 | 10 | 52 | 156 | 23 |
P value = 0.014 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 313 | 133 | 99 |
subtype1 | 121 | 58 | 30 |
subtype2 | 43 | 29 | 23 |
subtype3 | 149 | 46 | 46 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 412 | 68 | 9 | 1 | 50 |
subtype1 | 149 | 19 | 6 | 1 | 33 |
subtype2 | 65 | 12 | 2 | 0 | 15 |
subtype3 | 198 | 37 | 1 | 0 | 2 |
P value = 0.54 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 257 | 292 |
subtype1 | 102 | 110 |
subtype2 | 40 | 56 |
subtype3 | 115 | 126 |
P value = 0.00024 (Fisher's exact test), Q value = 0.032
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 351 | 53 | 127 | 10 |
subtype1 | 140 | 10 | 60 | 1 |
subtype2 | 61 | 19 | 13 | 2 |
subtype3 | 150 | 24 | 54 | 7 |
P value = 0.0952 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 9 | 540 |
subtype1 | 3 | 209 |
subtype2 | 4 | 92 |
subtype3 | 2 | 239 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 384 | 5 | 36 | 26 |
subtype1 | 121 | 2 | 5 | 17 |
subtype2 | 66 | 0 | 2 | 7 |
subtype3 | 197 | 3 | 29 | 2 |
P value = 0.0488 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 514 | 2.2 (4.7) |
subtype1 | 189 | 1.8 (3.5) |
subtype2 | 89 | 3.3 (7.1) |
subtype3 | 236 | 2.1 (4.4) |
P value = 0.659 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 26 | 280 |
subtype1 | 0 | 7 | 14 | 171 |
subtype2 | 1 | 4 | 7 | 73 |
subtype3 | 0 | 1 | 5 | 36 |
Cluster Labels | 1 | 2 | 3 |
---|---|---|---|
Number of samples | 229 | 144 | 176 |
P value = 0.678 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 520 | 102 | 0.1 - 140.4 (19.1) |
subtype1 | 223 | 48 | 0.1 - 140.4 (16.1) |
subtype2 | 135 | 25 | 0.1 - 139.2 (17.9) |
subtype3 | 162 | 29 | 0.9 - 83.8 (24.0) |
P value = 0.00428 (Kruskal-Wallis (anova)), Q value = 0.53
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 548 | 66.8 (12.7) |
subtype1 | 228 | 65.8 (12.8) |
subtype2 | 144 | 65.1 (13.0) |
subtype3 | 176 | 69.6 (11.9) |
P value = 0.262 (Fisher's exact test), Q value = 1
nPatients | COLON | RECTUM |
---|---|---|
ALL | 405 | 140 |
subtype1 | 176 | 51 |
subtype2 | 100 | 43 |
subtype3 | 129 | 46 |
P value = 0.0103 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE IA | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA | STAGE IVB |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 94 | 1 | 36 | 154 | 10 | 2 | 27 | 16 | 69 | 45 | 57 | 23 | 1 |
subtype1 | 36 | 0 | 10 | 78 | 4 | 1 | 8 | 8 | 28 | 18 | 13 | 14 | 1 |
subtype2 | 22 | 1 | 6 | 34 | 2 | 1 | 7 | 6 | 21 | 14 | 23 | 4 | 0 |
subtype3 | 36 | 0 | 20 | 42 | 4 | 0 | 12 | 2 | 20 | 13 | 21 | 5 | 0 |
P value = 0.919 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 20 | 95 | 376 | 56 |
subtype1 | 8 | 37 | 158 | 25 |
subtype2 | 6 | 22 | 101 | 14 |
subtype3 | 6 | 36 | 117 | 17 |
P value = 0.123 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 313 | 133 | 99 |
subtype1 | 138 | 53 | 35 |
subtype2 | 69 | 42 | 32 |
subtype3 | 106 | 38 | 32 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | M0 | M1 | M1A | M1B | MX |
---|---|---|---|---|---|
ALL | 412 | 68 | 9 | 1 | 50 |
subtype1 | 163 | 19 | 5 | 1 | 36 |
subtype2 | 103 | 25 | 2 | 0 | 13 |
subtype3 | 146 | 24 | 2 | 0 | 1 |
P value = 0.517 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 257 | 292 |
subtype1 | 101 | 128 |
subtype2 | 72 | 72 |
subtype3 | 84 | 92 |
P value = 0.341 (Fisher's exact test), Q value = 1
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 351 | 53 | 127 | 10 |
subtype1 | 151 | 25 | 49 | 2 |
subtype2 | 90 | 9 | 40 | 3 |
subtype3 | 110 | 19 | 38 | 5 |
P value = 0.398 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 9 | 540 |
subtype1 | 6 | 223 |
subtype2 | 1 | 143 |
subtype3 | 2 | 174 |
P value = 7e-05 (Fisher's exact test), Q value = 0.0097
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 384 | 5 | 36 | 26 |
subtype1 | 142 | 2 | 4 | 17 |
subtype2 | 95 | 1 | 15 | 7 |
subtype3 | 147 | 2 | 17 | 2 |
P value = 0.127 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 514 | 2.2 (4.7) |
subtype1 | 212 | 1.9 (3.9) |
subtype2 | 129 | 2.5 (5.4) |
subtype3 | 173 | 2.3 (5.2) |
P value = 0.792 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 12 | 26 | 280 |
subtype1 | 1 | 8 | 15 | 181 |
subtype2 | 0 | 4 | 7 | 68 |
subtype3 | 0 | 0 | 4 | 31 |
Cluster Labels | 1 | 2 | 3 | 4 | 5 | 6 |
---|---|---|---|---|---|---|
Number of samples | 24 | 20 | 29 | 28 | 18 | 17 |
P value = 0.588 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 133 | 36 | 0.1 - 140.4 (15.0) |
subtype1 | 23 | 6 | 0.2 - 130.7 (20.6) |
subtype2 | 20 | 6 | 0.1 - 47.1 (15.6) |
subtype3 | 28 | 6 | 0.2 - 129.3 (13.2) |
subtype4 | 27 | 10 | 0.1 - 140.4 (12.6) |
subtype5 | 18 | 4 | 1.0 - 139.2 (13.9) |
subtype6 | 17 | 4 | 0.1 - 131.5 (21.4) |
P value = 0.201 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 135 | 64.9 (12.6) |
subtype1 | 24 | 68.0 (12.5) |
subtype2 | 20 | 62.6 (14.2) |
subtype3 | 29 | 61.9 (12.3) |
subtype4 | 28 | 66.4 (10.9) |
subtype5 | 18 | 62.4 (12.8) |
subtype6 | 16 | 68.6 (13.2) |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON | RECTUM |
---|---|---|
ALL | 85 | 50 |
subtype1 | 13 | 11 |
subtype2 | 20 | 0 |
subtype3 | 6 | 22 |
subtype4 | 16 | 12 |
subtype5 | 16 | 2 |
subtype6 | 14 | 3 |
P value = 0.196 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 15 | 7 | 39 | 1 | 1 | 2 | 4 | 21 | 14 | 13 | 9 |
subtype1 | 6 | 1 | 7 | 0 | 0 | 1 | 0 | 4 | 1 | 2 | 1 |
subtype2 | 2 | 1 | 4 | 0 | 0 | 0 | 0 | 4 | 4 | 4 | 1 |
subtype3 | 0 | 1 | 8 | 0 | 0 | 0 | 1 | 5 | 4 | 4 | 4 |
subtype4 | 1 | 0 | 10 | 0 | 1 | 1 | 3 | 4 | 2 | 0 | 1 |
subtype5 | 2 | 2 | 4 | 1 | 0 | 0 | 0 | 1 | 1 | 3 | 2 |
subtype6 | 4 | 2 | 6 | 0 | 0 | 0 | 0 | 3 | 2 | 0 | 0 |
P value = 0.143 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 4 | 16 | 100 | 15 |
subtype1 | 2 | 5 | 15 | 2 |
subtype2 | 0 | 2 | 16 | 2 |
subtype3 | 0 | 0 | 26 | 2 |
subtype4 | 1 | 3 | 21 | 3 |
subtype5 | 0 | 3 | 10 | 5 |
subtype6 | 1 | 3 | 12 | 1 |
P value = 0.183 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 66 | 39 | 29 |
subtype1 | 14 | 6 | 4 |
subtype2 | 7 | 5 | 8 |
subtype3 | 9 | 10 | 8 |
subtype4 | 13 | 10 | 5 |
subtype5 | 10 | 6 | 2 |
subtype6 | 13 | 2 | 2 |
P value = 0.127 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | M1A | MX |
---|---|---|---|---|
ALL | 87 | 17 | 4 | 23 |
subtype1 | 17 | 2 | 0 | 5 |
subtype2 | 11 | 5 | 0 | 3 |
subtype3 | 17 | 6 | 1 | 4 |
subtype4 | 18 | 1 | 1 | 5 |
subtype5 | 8 | 3 | 2 | 5 |
subtype6 | 16 | 0 | 0 | 1 |
P value = 0.857 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 78 |
subtype1 | 8 | 16 |
subtype2 | 9 | 11 |
subtype3 | 15 | 14 |
subtype4 | 12 | 16 |
subtype5 | 7 | 11 |
subtype6 | 7 | 10 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 75 | 10 | 49 | 1 |
subtype1 | 13 | 0 | 11 | 0 |
subtype2 | 16 | 4 | 0 | 0 |
subtype3 | 6 | 0 | 22 | 0 |
subtype4 | 14 | 2 | 11 | 1 |
subtype5 | 12 | 4 | 2 | 0 |
subtype6 | 14 | 0 | 3 | 0 |
P value = 0.881 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 4 | 132 |
subtype1 | 1 | 23 |
subtype2 | 0 | 20 |
subtype3 | 2 | 27 |
subtype4 | 1 | 27 |
subtype5 | 0 | 18 |
subtype6 | 0 | 17 |
P value = 0.533 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 73 | 1 | 2 | 7 |
subtype1 | 12 | 0 | 0 | 2 |
subtype2 | 14 | 0 | 0 | 0 |
subtype3 | 18 | 0 | 2 | 2 |
subtype4 | 11 | 1 | 0 | 0 |
subtype5 | 9 | 0 | 0 | 1 |
subtype6 | 9 | 0 | 0 | 2 |
P value = 0.0318 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 125 | 2.9 (6.2) |
subtype1 | 23 | 2.6 (4.4) |
subtype2 | 19 | 6.9 (11.6) |
subtype3 | 25 | 3.1 (4.7) |
subtype4 | 26 | 2.0 (5.4) |
subtype5 | 17 | 1.4 (3.0) |
subtype6 | 15 | 1.1 (2.3) |
P value = 0.218 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 3 | 8 | 117 |
subtype1 | 0 | 0 | 2 | 20 |
subtype2 | 1 | 0 | 2 | 16 |
subtype3 | 0 | 1 | 0 | 25 |
subtype4 | 0 | 0 | 1 | 27 |
subtype5 | 0 | 0 | 2 | 15 |
subtype6 | 0 | 2 | 1 | 14 |
Cluster Labels | 1 | 2 | 3 | 4 |
---|---|---|---|---|
Number of samples | 55 | 15 | 34 | 32 |
P value = 0.557 (logrank test), Q value = 1
nPatients | nDeath | Duration Range (Median), Month | |
---|---|---|---|
ALL | 133 | 36 | 0.1 - 140.4 (15.0) |
subtype1 | 55 | 17 | 0.1 - 100.0 (13.4) |
subtype2 | 15 | 3 | 0.7 - 129.3 (14.5) |
subtype3 | 33 | 9 | 0.2 - 131.5 (24.1) |
subtype4 | 30 | 7 | 0.2 - 140.4 (13.8) |
P value = 0.516 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 135 | 64.9 (12.6) |
subtype1 | 55 | 64.6 (13.8) |
subtype2 | 15 | 61.7 (12.3) |
subtype3 | 33 | 67.3 (12.6) |
subtype4 | 32 | 64.3 (10.5) |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON | RECTUM |
---|---|---|
ALL | 85 | 50 |
subtype1 | 50 | 5 |
subtype2 | 5 | 9 |
subtype3 | 18 | 16 |
subtype4 | 12 | 20 |
P value = 0.77 (Fisher's exact test), Q value = 1
nPatients | STAGE I | STAGE II | STAGE IIA | STAGE IIB | STAGE IIC | STAGE III | STAGE IIIA | STAGE IIIB | STAGE IIIC | STAGE IV | STAGE IVA |
---|---|---|---|---|---|---|---|---|---|---|---|
ALL | 15 | 7 | 39 | 1 | 1 | 2 | 4 | 21 | 14 | 13 | 9 |
subtype1 | 9 | 3 | 15 | 1 | 0 | 0 | 0 | 7 | 7 | 6 | 2 |
subtype2 | 0 | 1 | 5 | 0 | 0 | 0 | 1 | 4 | 1 | 1 | 2 |
subtype3 | 4 | 2 | 9 | 0 | 1 | 1 | 2 | 7 | 3 | 2 | 1 |
subtype4 | 2 | 1 | 10 | 0 | 0 | 1 | 1 | 3 | 3 | 4 | 4 |
P value = 0.441 (Fisher's exact test), Q value = 1
nPatients | T1 | T2 | T3 | T4 |
---|---|---|---|---|
ALL | 4 | 16 | 100 | 15 |
subtype1 | 1 | 9 | 36 | 9 |
subtype2 | 0 | 0 | 14 | 1 |
subtype3 | 2 | 5 | 25 | 2 |
subtype4 | 1 | 2 | 25 | 3 |
P value = 0.788 (Fisher's exact test), Q value = 1
nPatients | N0 | N1 | N2 |
---|---|---|---|
ALL | 66 | 39 | 29 |
subtype1 | 31 | 12 | 12 |
subtype2 | 6 | 5 | 4 |
subtype3 | 15 | 12 | 7 |
subtype4 | 14 | 10 | 6 |
P value = 0.491 (Fisher's exact test), Q value = 1
nPatients | M0 | M1 | M1A | MX |
---|---|---|---|---|
ALL | 87 | 17 | 4 | 23 |
subtype1 | 34 | 7 | 1 | 11 |
subtype2 | 10 | 1 | 1 | 3 |
subtype3 | 23 | 3 | 0 | 7 |
subtype4 | 20 | 6 | 2 | 2 |
P value = 0.326 (Fisher's exact test), Q value = 1
nPatients | FEMALE | MALE |
---|---|---|
ALL | 58 | 78 |
subtype1 | 23 | 32 |
subtype2 | 9 | 6 |
subtype3 | 11 | 23 |
subtype4 | 15 | 17 |
P value = 1e-05 (Fisher's exact test), Q value = 0.0016
nPatients | COLON ADENOCARCINOMA | COLON MUCINOUS ADENOCARCINOMA | RECTAL ADENOCARCINOMA | RECTAL MUCINOUS ADENOCARCINOMA |
---|---|---|---|---|
ALL | 75 | 10 | 49 | 1 |
subtype1 | 42 | 8 | 5 | 0 |
subtype2 | 5 | 0 | 9 | 0 |
subtype3 | 18 | 0 | 15 | 1 |
subtype4 | 10 | 2 | 20 | 0 |
P value = 0.144 (Fisher's exact test), Q value = 1
nPatients | NO | YES |
---|---|---|
ALL | 4 | 132 |
subtype1 | 0 | 55 |
subtype2 | 1 | 14 |
subtype3 | 2 | 32 |
subtype4 | 1 | 31 |
P value = 0.355 (Fisher's exact test), Q value = 1
nPatients | R0 | R1 | R2 | RX |
---|---|---|---|---|
ALL | 73 | 1 | 2 | 7 |
subtype1 | 33 | 0 | 0 | 3 |
subtype2 | 11 | 0 | 0 | 1 |
subtype3 | 13 | 1 | 0 | 2 |
subtype4 | 16 | 0 | 2 | 1 |
P value = 0.348 (Kruskal-Wallis (anova)), Q value = 1
nPatients | Mean (Std.Dev) | |
---|---|---|
ALL | 125 | 2.9 (6.2) |
subtype1 | 51 | 3.0 (7.7) |
subtype2 | 14 | 3.6 (5.8) |
subtype3 | 32 | 3.3 (5.8) |
subtype4 | 28 | 1.8 (2.9) |
P value = 0.793 (Fisher's exact test), Q value = 1
nPatients | AMERICAN INDIAN OR ALASKA NATIVE | ASIAN | BLACK OR AFRICAN AMERICAN | WHITE |
---|---|---|---|---|
ALL | 1 | 3 | 8 | 117 |
subtype1 | 1 | 1 | 5 | 46 |
subtype2 | 0 | 1 | 0 | 13 |
subtype3 | 0 | 1 | 2 | 30 |
subtype4 | 0 | 0 | 1 | 28 |
-
Cluster data file = COADREAD-TP.mergedcluster.txt
-
Clinical data file = COADREAD-TP.merged_data.txt
-
Number of patients = 617
-
Number of clustering approaches = 12
-
Number of selected clinical features = 13
-
Exclude small clusters that include fewer than K patients, K = 3
consensus non-negative matrix factorization clustering approach (Brunet et al. 2004)
Resampling-based clustering method (Monti et al. 2003)
For survival clinical features, the Kaplan-Meier survival curves of tumors with and without gene mutations were plotted and the statistical significance P values were estimated by logrank test (Bland and Altman 2004) using the 'survdiff' function in R
For binary clinical features, two-tailed Fisher's exact tests (Fisher 1922) were used to estimate the P values using the 'fisher.test' function in R
For multiple hypothesis correction, Q value is the False Discovery Rate (FDR) analogue of the P value (Benjamini and Hochberg 1995), defined as the minimum FDR at which the test may be called significant. We used the 'Benjamini and Hochberg' method of 'p.adjust' function in R to convert P values into Q values.
In addition to the links below, the full results of the analysis summarized in this report can also be downloaded programmatically using firehose_get, or interactively from either the Broad GDAC website or TCGA Data Coordination Center Portal.