Clinical Features	MRNA_CNMF		MRNA_CHIERARCHICAL		CN_CNMF		METHLYATION_CNMF		RPPA_CNMF		RPPA_CHIERARCHICAL		MRNASEQ_CNMF		MRNASEQ_CHIERARCHICAL		MIRSEQ_CNMF		MIRSEQ_CHIERARCHICAL	
	nMutated (%)	nWild-Type	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q	Fisher's exact test_P	Fisher's exact test_Q
APC	163 (73%)	60	0.0056599	1	0.00091999	0.347	0.04292	1	NA	NA	0.29884	1	0.15531	1	0.78781	1	3e-05	0.0118	0.64375	1	0.83295	1
TP53	117 (52%)	106	0.00288	1	0.00075999	0.287	9.9999e-06	0.00401	NA	NA	0.75397	1	0.95522	1	0.04796	1	2e-05	0.0079	0.03228	1	0.25632	1
KRAS	97 (43%)	126	0.00022	0.0856	0.00032	0.123	0.23641	1	0.10668	1	0.56983	1	0.9536	1	0.00296	1	9.9999e-06	0.00401	0.02163	1	0.1401	1
NRAS	20 (9%)	203	0.04659	1	0.03247	1	0.081249	1	NA	NA	0.90812	1	0.6349	1	0.313	1	0.24306	1	0.26633	1	0.62776	1
SMAD4	26 (12%)	197	0.03131	1	0.073749	1	0.094849	1	NA	NA	0.85858	1	1	1	0.50434	1	0.11406	1	1	1	0.36738	1
FBXW7	38 (17%)	185	0.059469	1	0.01815	1	0.00111	0.415	NA	NA	0.011	1	0.11867	1	0.00476	1	0.00015	0.0586	0.41692	1	0.01325	1
SMAD2	15 (7%)	208	0.13142	1	0.67703	1	0.10442	1	NA	NA	0.59081	1	0.67376	1	0.67963	1	0.0059299	1	1	1	0.73128	1
FAM123B	24 (11%)	199	0.089999	1	0.30338	1	0.0087599	1	NA	NA	0.54109	1	1	1	0.21539	1	0.33711	1	1	1	0.061199	1
PIK3CA	33 (15%)	190	0.20344	1	0.40899	1	0.00045	0.171	NA	NA	0.061479	1	0.31214	1	0.076069	1	0.00302	1	0.16608	1	0.74438	1
TCF7L2	18 (8%)	205	1	1	0.6341	1	0.85893	1	NA	NA	0.83845	1	0.60861	1	0.34196	1	0.90653	1	1	1	0.13118	1
ARID1A	20 (9%)	203	0.02383	1	0.19537	1	0.00425	1	NA	NA	0.97826	1	0.51034	1	1	1	0.36379	1	1	1	0.01337	1
BRAF	21 (9%)	202	9.9999e-06	0.00401	9.9999e-06	0.00401	5e-05	0.0196	NA	NA	0.40071	1	1	1	0.22051	1	9.9999e-06	0.00401	1	1	0.14721	1
MGC42105	11 (5%)	212	0.00154	0.573	0.058809	1	0.10983	1	NA	NA	0.13472	1	1	1	1	1	0.02588	1	1	1	0.24647	1
ACVR1B	14 (6%)	209	0.37249	1	0.02698	1	0.01002	1	NA	NA	0.73434	1	0.19227	1	1	1	0.082699	1	0.58093	1	0.22628	1
CDC27	13 (6%)	210	0.00037	0.142	0.24693	1	0.00017	0.0663	NA	NA	0.93707	1	0.82448	1	0.49468	1	0.00381	1	0.46232	1	0.00263	0.973
KIAA1804	15 (7%)	208	0.26828	1	0.89444	1	0.01772	1	NA	NA	0.50434	1	0.75007	1	0.67993	1	0.053069	1	1	1	0.20817	1
PCDHGB1	8 (4%)	215	0.20627	1	0.19681	1	0.097729	1	NA	NA	0.50831	1	0.67142	1	0.6901	1	0.42195	1	1	1	0.25049	1
PCBP1	5 (2%)	218	0.56594	1	0.72905	1	0.73853	1	NA	NA	NA	NA	NA	NA	1	1	0.4617	1	1	1	1	1
ZHX2	10 (4%)	213	0.11798	1	0.22335	1	0.46443	1	NA	NA	0.23743	1	0.22127	1	0.65601	1	0.24852	1	1	1	0.20453	1
PCDHA3	12 (5%)	211	0.04502	1	0.00031	0.12	0.052109	1	NA	NA	0.84826	1	1	1	0.49474	1	0.10735	1	1	1	0.36882	1
PCDHA2	12 (5%)	211	0.20565	1	0.78433	1	0.051369	1	NA	NA	0.90577	1	1	1	0.90297	1	0.54126	1	0.52258	1	0.079819	1
ELF3	8 (4%)	215	0.7952	1	0.79881	1	0.03607	1	NA	NA	0.87906	1	0.33873	1	0.01759	1	0.083539	1	1	1	0.25687	1
CRTC1	4 (2%)	219	0.064999	1	0.1175	1	0.83145	1	NA	NA	NA	NA	NA	NA	1	1	0.54679	1	1	1	1	1
CASP8	10 (4%)	213	0.00029	0.112	9.9999e-06	0.00401	0.00027	0.105	NA	NA	0.04301	1	0.22881	1	1	1	5.9999e-05	0.0235	1	1	0.057229	1
CACNG3	8 (4%)	215	0.01531	1	0.20262	1	0.00263	0.973	NA	NA	0.12485	1	0.33619	1	0.16344	1	0.02204	1	0.38837	1	0.02672	1
PCDHGA7	5 (2%)	218	0.36502	1	0.49195	1	0.21717	1	NA	NA	NA	NA	NA	NA	0.71987	1	1	1	1	1	0.6467	1
CCBP2	10 (4%)	213	0.15922	1	0.03742	1	0.38748	1	NA	NA	0.070729	1	1	1	0.44326	1	0.087369	1	1	1	0.37239	1
MAP2K4	11 (5%)	212	0.46147	1	0.44761	1	0.03701	1	NA	NA	0.10082	1	0.52361	1	0.49889	1	0.61213	1	1	1	0.37489	1
PCDHGA9	6 (3%)	217	0.068409	1	0.076789	1	0.65798	1	NA	NA	0.67149	1	0.59206	1	0.44726	1	0.12042	1	1	1	0.73379	1
RBM10	8 (4%)	215	0.2792	1	0.73758	1	0.89985	1	NA	NA	0.23753	1	0.73917	1	1	1	0.075959	1	1	1	1	1
PTEN	7 (3%)	216	0.02737	1	0.39452	1	0.03347	1	NA	NA	0.54597	1	1	1	0.097629	1	0.00058999	0.224	0.34661	1	0.02512	1
DNMT1	17 (8%)	206	0.02376	1	0.065209	1	0.11338	1	NA	NA	0.053299	1	0.33383	1	0.40678	1	0.00432	1	1	1	0.069909	1
BCOR	9 (4%)	214	0.01961	1	0.28123	1	0.0053699	1	NA	NA	0.46078	1	1	1	0.84248	1	0.02699	1	1	1	0.02524	1
PCDHGB5	7 (3%)	216	0.099839	1	0.072539	1	0.076469	1	NA	NA	0.88047	1	0.73908	1	0.050909	1	0.50068	1	1	1	1	1
ZFP3	8 (4%)	215	0.00044	0.168	0.059279	1	0.00095999	0.361	NA	NA	0.29093	1	0.73969	1	0.24847	1	0.00043	0.165	1	1	0.0071799	1
RWDD2B	7 (3%)	216	0.02661	1	0.73352	1	0.03287	1	NA	NA	0.85852	1	0.48555	1	1	1	0.20291	1	1	1	0.00059999	0.227
TBC1D10C	3 (1%)	220	0.69	1	0.23843	1	0.78746	1	NA	NA	NA	NA	NA	NA	1	1	0.20094	1	1	1	0.59585	1
ERCC6L	5 (2%)	218	0.0050299	1	0.48959	1	0.30063	1	NA	NA	NA	NA	NA	NA	0.72557	1	1	1	1	1	0.19003	1
ERBB3	14 (6%)	209	0.13522	1	0.04146	1	0.12107	1	NA	NA	0.66253	1	0.72801	1	1	1	0.18089	1	1	1	0.054209	1
KLK2	3 (1%)	220	0.53939	1	0.13294	1	0.46672	1	NA	NA	NA	NA	NA	NA	1	1	0.40011	1	NA	NA	NA	NA
TAPBP	5 (2%)	218	0.10224	1	0.64248	1	0.30206	1	NA	NA	1	1	0.17647	1	0.3611	1	0.22427	1	1	1	0.01313	1
ERBB2	9 (4%)	214	0.37892	1	0.18977	1	0.57396	1	NA	NA	0.076699	1	0.28833	1	0.34005	1	0.1717	1	0.38503	1	0.11502	1
MORC2	5 (2%)	218	0.1824	1	0.64105	1	0.14628	1	NA	NA	0.21014	1	0.48449	1	0.72005	1	0.01956	1	1	1	0.13747	1
ABCA8	12 (5%)	211	0.00143	0.533	0.02406	1	0.0056999	1	NA	NA	0.03061	1	0.28763	1	0.45881	1	0.01281	1	0.49249	1	0.36695	1
SETD2	13 (6%)	210	0.03513	1	0.18189	1	0.00095999	0.361	NA	NA	0.092899	1	0.73948	1	0.092939	1	0.00218	0.809	1	1	0.44314	1
ESR1	11 (5%)	212	0.19376	1	0.0092999	1	0.01041	1	NA	NA	0.71769	1	0.28799	1	0.88395	1	0.16913	1	1	1	0.17923	1