E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.033 0.026 -9999.0 0.0 -0.464 1.0 1.0 KLHL20 -0.019 0.054 -9999.0 0.0 -0.231 29.0 29.0 CYFIP2 0.001 0.08 -9999.0 0.0 -0.585 11.0 11.0 Rac1/GDP 0.044 0.04 -9999.0 0.0 -0.489 1.0 1.0 ENAH 0.026 0.052 -9999.0 0.0 -0.484 2.0 2.0 AP1M1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 RAP1B 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.004 0.032 -9999.0 0.0 -0.412 2.0 2.0 ABI1/Sra1/Nap1 -0.015 0.041 -9999.0 0.0 -0.212 11.0 11.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.013 0.072 -9999.0 0.0 -0.326 20.0 20.0 RAPGEF1 0.04 0.033 -9999.0 0.0 -0.446 2.0 2.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.027 0.026 -9999.0 0.0 -0.483 1.0 1.0 CRK 0.037 0.028 -9999.0 0.0 -0.432 1.0 1.0 E-cadherin/gamma catenin/alpha catenin 0.021 0.031 -9999.0 0.0 -0.356 4.0 4.0 alphaE/beta7 Integrin -0.003 0.09 -9999.0 0.0 -0.391 30.0 30.0 IQGAP1 0.009 0.039 -9999.0 0.0 -0.542 3.0 3.0 NCKAP1 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 Rap1/GTP/I-afadin 0.021 0.024 -9999.0 0.0 -0.325 3.0 3.0 DLG1 0.031 0.033 -9999.0 0.0 -0.464 1.0 1.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.003 0.026 -9999.0 0.0 -0.257 5.0 5.0 MLLT4 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 ARF6/GTP/NME1/Tiam1 -0.01 0.094 -9999.0 0.0 -0.325 32.0 32.0 PI3K -0.004 0.034 -9999.0 0.0 -0.34 5.0 5.0 ARF6 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.016 0.025 -9999.0 0.0 -0.424 2.0 2.0 TIAM1 -0.044 0.163 -9999.0 0.0 -0.52 63.0 63.0 E-cadherin(dimer)/Ca2+ 0.026 0.023 -9999.0 0.0 -0.3 3.0 3.0 AKT1 -0.003 0.023 -9999.0 0.0 -0.234 4.0 4.0 PIK3R1 0.008 0.042 -9999.0 0.0 -0.585 3.0 3.0 CDH1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 RhoA/GDP 0.043 0.041 -9999.0 0.0 -0.489 1.0 1.0 actin cytoskeleton organization 0.017 0.051 -9999.0 0.0 -0.201 7.0 7.0 CDC42/GDP 0.041 0.047 -9999.0 0.0 -0.427 2.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.019 0.023 -9999.0 0.0 -0.264 4.0 4.0 ITGB7 -0.016 0.119 -9999.0 0.0 -0.534 30.0 30.0 RAC1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.028 0.024 -9999.0 0.0 -0.318 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.019 0.023 -9999.0 0.0 -0.306 3.0 3.0 mol:GDP 0.041 0.045 -9999.0 0.0 -0.458 2.0 2.0 CDC42/GTP/IQGAP1 0.011 0.05 -9999.0 0.0 -0.457 6.0 6.0 JUP 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 p120 catenin/RhoA/GDP 0.035 0.041 -9999.0 0.0 -0.495 1.0 1.0 RAC1/GTP/IQGAP1 0.014 0.025 -9999.0 0.0 -0.331 3.0 3.0 PIP5K1C/AP1M1 0.016 0.032 -9999.0 0.0 -0.778 1.0 1.0 RHOA 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 CDC42 0.007 0.054 -9999.0 0.0 -0.585 5.0 5.0 CTNNA1 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 positive regulation of S phase of mitotic cell cycle 0.016 0.036 -9999.0 0.0 -0.263 2.0 2.0 NME1 0.011 0.019 -9999.0 0.0 -0.457 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.032 0.028 -9999.0 0.0 -0.464 1.0 1.0 regulation of cell-cell adhesion -0.004 0.028 -9999.0 0.0 -0.354 2.0 2.0 WASF2 -0.007 0.021 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.003 0.026 -9999.0 0.0 -0.447 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.017 0.071 -9999.0 0.0 -0.436 1.0 1.0 CCND1 0.018 0.044 -9999.0 0.0 -0.334 2.0 2.0 VAV2 0.009 0.154 -9999.0 0.0 -0.686 28.0 28.0 RAP1/GDP 0.036 0.036 -9999.0 0.0 -0.49 1.0 1.0 adherens junction assembly 0.032 0.028 -9999.0 0.0 -0.449 1.0 1.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 PIP5K1C 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.022 0.068 -9999.0 0.0 -0.415 1.0 1.0 E-cadherin/beta catenin -0.0 0.022 -9999.0 0.0 -0.355 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.032 0.028 -9999.0 0.0 -0.464 1.0 1.0 PIK3CA 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 Rac1/GTP -0.03 0.087 -9999.0 0.0 -0.379 28.0 28.0 E-cadherin/beta catenin/alpha catenin 0.022 0.027 -9999.0 0.0 -0.356 3.0 3.0 ITGAE 0.011 0.019 -9999.0 0.0 -0.457 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.027 0.027 -9999.0 0.0 -0.494 1.0 1.0