Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.052 0.222 -9999.0 0.0 -0.631 55.0 55.0 IHH -0.039 0.168 -9999.0 0.0 -0.628 43.0 43.0 SHH Np/Cholesterol/GAS1 -0.082 0.159 -9999.0 0.0 -0.306 190.0 190.0 LRPAP1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 dorsoventral neural tube patterning 0.081 0.157 0.304 190.0 -9999.0 0.0 190.0 SMO/beta Arrestin2 -0.038 0.193 -9999.0 0.0 -0.642 35.0 35.0 SMO -0.046 0.204 -9999.0 0.0 -0.668 37.0 37.0 AKT1 -0.005 0.111 -9999.0 0.0 -0.505 11.0 11.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.032 0.141 -9999.0 0.0 -0.481 54.0 54.0 ADRBK1 0.01 0.031 -9999.0 0.0 -0.521 2.0 2.0 heart looping -0.044 0.2 -9999.0 0.0 -0.64 39.0 39.0 STIL -0.027 0.163 -9999.0 0.0 -0.584 30.0 30.0 DHH N/PTCH2 -0.041 0.156 -9999.0 0.0 -0.433 78.0 78.0 DHH N/PTCH1 -0.047 0.17 -9999.0 0.0 -0.443 54.0 54.0 PIK3CA 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 DHH -0.03 0.145 -9999.0 0.0 -0.544 44.0 44.0 PTHLH -0.078 0.297 -9999.0 0.0 -0.923 54.0 54.0 determination of left/right symmetry -0.044 0.2 -9999.0 0.0 -0.64 39.0 39.0 PIK3R1 0.008 0.042 -9999.0 0.0 -0.585 3.0 3.0 skeletal system development -0.077 0.293 -9999.0 0.0 -0.91 54.0 54.0 IHH N/Hhip -0.085 0.205 -9999.0 0.0 -0.463 128.0 128.0 DHH N/Hhip -0.079 0.189 -9999.0 0.0 -0.422 132.0 132.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.044 0.2 -9999.0 0.0 -0.64 39.0 39.0 pancreas development -0.081 0.208 -9999.0 0.0 -0.546 100.0 100.0 HHAT 0.004 0.068 -9999.0 0.0 -0.585 8.0 8.0 PI3K 0.013 0.04 -9999.0 0.0 -0.426 5.0 5.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.131 0.238 -9999.0 0.0 -0.52 163.0 163.0 somite specification -0.044 0.2 -9999.0 0.0 -0.64 39.0 39.0 SHH Np/Cholesterol/PTCH1 -0.033 0.171 -9999.0 0.0 -0.603 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.025 0.118 -9999.0 0.0 -0.32 80.0 80.0 SHH Np/Cholesterol/Megalin -0.023 0.108 -9999.0 0.0 -0.359 36.0 36.0 SHH -0.01 0.108 -9999.0 0.0 -0.414 40.0 40.0 catabolic process -0.033 0.164 -9999.0 0.0 -0.426 60.0 60.0 SMO/Vitamin D3 -0.041 0.194 -9999.0 0.0 -0.633 40.0 40.0 SHH Np/Cholesterol/Hhip -0.054 0.151 -9999.0 0.0 -0.364 95.0 95.0 LRP2 -0.027 0.119 -9999.0 0.0 -0.457 43.0 43.0 receptor-mediated endocytosis -0.044 0.19 -9999.0 0.0 -0.631 37.0 37.0 SHH Np/Cholesterol/BOC -0.026 0.117 -9999.0 0.0 -0.357 45.0 45.0 SHH Np/Cholesterol/CDO -0.008 0.101 -9999.0 0.0 -0.357 41.0 41.0 mesenchymal cell differentiation 0.054 0.15 0.361 95.0 -9999.0 0.0 95.0 mol:Vitamin D3 -0.031 0.173 -9999.0 0.0 -0.605 32.0 32.0 IHH N/PTCH2 -0.044 0.161 -9999.0 0.0 -0.437 81.0 81.0 CDON -0.001 0.081 -9999.0 0.0 -0.521 14.0 14.0 IHH N/PTCH1 -0.032 0.166 -9999.0 0.0 -0.43 60.0 60.0 Megalin/LRPAP1 -0.011 0.087 -9999.0 0.0 -0.32 44.0 44.0 PTCH2 -0.029 0.145 -9999.0 0.0 -0.544 44.0 44.0 SHH Np/Cholesterol -0.009 0.083 -9999.0 0.0 -0.322 40.0 40.0 PTCH1 -0.033 0.164 -9999.0 0.0 -0.439 54.0 54.0 HHIP -0.081 0.208 -9999.0 0.0 -0.546 100.0 100.0