Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.021 0.036 -9999.0 0.0 -0.256 10.0 10.0 epithelial cell differentiation 0.023 0.023 -9999.0 0.0 -0.297 3.0 3.0 CYFIP2 0.001 0.08 -9999.0 0.0 -0.585 11.0 11.0 ENAH 0.037 0.067 -9999.0 0.0 -0.428 6.0 6.0 EGFR 0.005 0.058 -9999.0 0.0 -0.53 7.0 7.0 EPHA2 0.006 0.055 -9999.0 0.0 -0.542 6.0 6.0 MYO6 0.029 0.022 -9999.0 0.0 -0.28 3.0 3.0 CTNNB1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.015 0.06 -9999.0 0.0 -0.382 13.0 13.0 AQP5 -0.038 0.101 -9999.0 0.0 -0.469 26.0 26.0 CTNND1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 0.028 0.025 -9999.0 0.0 -0.277 4.0 4.0 regulation of calcium-dependent cell-cell adhesion -0.003 0.093 -9999.0 0.0 -0.285 47.0 47.0 EGF -0.18 0.253 -9999.0 0.0 -0.509 222.0 222.0 NCKAP1 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 AQP3 -0.022 0.066 -9999.0 0.0 -0.469 8.0 8.0 cortical microtubule organization 0.023 0.023 -9999.0 0.0 -0.297 3.0 3.0 GO:0000145 0.026 0.024 -9999.0 0.0 -0.264 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.026 0.023 -9999.0 0.0 -0.3 3.0 3.0 MLLT4 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 ARF6/GDP -0.005 0.039 -9999.0 0.0 -0.489 2.0 2.0 ARF6 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.024 0.045 -9999.0 0.0 -0.371 6.0 6.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP 0.036 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.01 0.031 -9999.0 0.0 -0.521 2.0 2.0 ZYX 0.028 0.025 -9999.0 0.0 -0.281 4.0 4.0 ARF6/GTP 0.027 0.047 -9999.0 0.0 -0.391 6.0 6.0 CDH1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 EGFR/EGFR/EGF/EGF -0.085 0.111 -9999.0 0.0 -0.481 1.0 1.0 RhoA/GDP -0.002 0.023 -9999.0 0.0 -0.278 4.0 4.0 actin cytoskeleton organization 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.01 0.024 -9999.0 0.0 -0.584 1.0 1.0 GIT1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 IGF1R 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 IGF1 -0.075 0.198 -9999.0 0.0 -0.525 97.0 97.0 DIAPH1 -0.013 0.091 -9999.0 0.0 -0.622 13.0 13.0 Wnt receptor signaling pathway -0.023 0.023 0.297 3.0 -9999.0 0.0 3.0 RHOA 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 RhoA/GTP -0.005 0.038 -9999.0 0.0 -0.486 2.0 2.0 CTNNA1 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 VCL 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.011 0.019 -9999.0 0.0 -0.457 1.0 1.0 LPP 0.033 0.026 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.004 0.031 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.003 0.025 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.003 0.095 -9999.0 0.0 -0.289 47.0 47.0 HGF/MET -0.024 0.074 -9999.0 0.0 -9999.0 0.0 0.0 HGF -0.039 0.161 -9999.0 0.0 -0.545 55.0 55.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.021 0.036 -9999.0 0.0 -0.258 10.0 10.0 actin cable formation 0.052 0.057 -9999.0 0.0 -0.351 5.0 5.0 KIAA1543 0.031 0.034 -9999.0 0.0 -9999.0 0.0 0.0 KIFC3 0.024 0.043 -9999.0 0.0 -0.282 10.0 10.0 NCK1 0.009 0.034 -9999.0 0.0 -0.585 2.0 2.0 EXOC3 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 0.029 0.022 -9999.0 0.0 -0.28 3.0 3.0 NCK1/GIT1 0.015 0.031 -9999.0 0.0 -0.424 3.0 3.0 mol:GDP 0.023 0.023 -9999.0 0.0 -0.297 3.0 3.0 EXOC4 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 0.029 0.022 -9999.0 0.0 -0.28 3.0 3.0 PIP5K1C 0.028 0.025 -9999.0 0.0 -0.281 4.0 4.0 LIMA1 0.005 0.064 -9999.0 0.0 -0.585 7.0 7.0 ABI1 0.01 0.024 -9999.0 0.0 -0.585 1.0 1.0 ROCK1 0.039 0.059 -9999.0 0.0 -0.475 4.0 4.0 adherens junction assembly 0.037 0.068 -9999.0 0.0 -0.444 7.0 7.0 IGF-1R heterotetramer/IGF1 -0.039 0.09 -9999.0 0.0 -0.558 1.0 1.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.014 0.034 -9999.0 0.0 -0.398 4.0 4.0 MET 0.01 0.031 -9999.0 0.0 -0.521 2.0 2.0 PLEKHA7 0.028 0.025 -9999.0 0.0 -0.281 4.0 4.0 mol:GTP 0.023 0.045 -9999.0 0.0 -0.369 6.0 6.0 establishment of epithelial cell apical/basal polarity 0.046 0.029 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization 0.021 0.036 -9999.0 0.0 -0.256 10.0 10.0 regulation of cell-cell adhesion 0.032 0.027 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.021 0.036 -9999.0 0.0 -0.258 10.0 10.0