E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.016 0.039 -9999.0 0.0 -0.308 6.0 6.0 KLHL20 0.035 0.083 0.198 29.0 -0.233 26.0 55.0 CYFIP2 0.018 0.061 -9999.0 0.0 -0.447 10.0 10.0 Rac1/GDP 0.059 0.087 0.289 6.0 -0.34 2.0 8.0 ENAH 0.012 0.05 -9999.0 0.0 -0.319 7.0 7.0 AP1M1 0.026 0.02 -9999.0 0.0 -0.447 1.0 1.0 RAP1B 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.012 0.032 -9999.0 0.0 -0.261 2.0 2.0 ABI1/Sra1/Nap1 -0.011 0.039 -9999.0 0.0 -0.168 28.0 28.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.05 0.056 -9999.0 0.0 -0.24 16.0 16.0 RAPGEF1 0.053 0.086 0.279 8.0 -0.329 4.0 12.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.025 0.041 -9999.0 0.0 -0.314 6.0 6.0 CRK 0.054 0.081 -9999.0 0.0 -0.363 2.0 2.0 E-cadherin/gamma catenin/alpha catenin 0.05 0.029 -9999.0 0.0 -0.274 4.0 4.0 alphaE/beta7 Integrin 0.024 0.061 -9999.0 0.0 -0.31 18.0 18.0 IQGAP1 0.024 0.028 -9999.0 0.0 -0.447 2.0 2.0 NCKAP1 0.025 0.027 -9999.0 0.0 -0.447 2.0 2.0 Rap1/GTP/I-afadin 0.048 0.021 -9999.0 0.0 -0.248 2.0 2.0 DLG1 0.015 0.042 -9999.0 0.0 -0.308 6.0 6.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.01 0.021 -9999.0 0.0 -0.223 2.0 2.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 ARF6/GTP/NME1/Tiam1 0.033 0.067 -9999.0 0.0 -0.246 29.0 29.0 PI3K 0.002 0.029 -9999.0 0.0 -0.29 2.0 2.0 ARF6 0.024 0.02 -9999.0 0.0 -0.447 1.0 1.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.037 0.022 -9999.0 0.0 -0.321 2.0 2.0 TIAM1 -0.005 0.104 -9999.0 0.0 -0.265 61.0 61.0 E-cadherin(dimer)/Ca2+ 0.059 0.026 -9999.0 0.0 -0.236 3.0 3.0 AKT1 0.018 0.049 0.094 25.0 -0.226 2.0 27.0 PIK3R1 0.024 0.028 -9999.0 0.0 -0.447 2.0 2.0 CDH1 0.026 0.02 -9999.0 0.0 -0.447 1.0 1.0 RhoA/GDP 0.07 0.091 0.304 9.0 -0.341 2.0 11.0 actin cytoskeleton organization 0.031 0.066 0.165 34.0 -0.171 24.0 58.0 CDC42/GDP 0.066 0.092 0.303 10.0 -0.341 2.0 12.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.02 -9999.0 0.0 -0.224 4.0 4.0 ITGB7 0.01 0.083 -9999.0 0.0 -0.447 18.0 18.0 RAC1 0.024 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.063 0.028 -9999.0 0.0 -0.251 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.045 0.022 -9999.0 0.0 -0.232 3.0 3.0 mol:GDP 0.062 0.099 0.314 11.0 -0.397 2.0 13.0 CDC42/GTP/IQGAP1 0.03 0.037 -9999.0 0.0 -0.387 4.0 4.0 JUP 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 p120 catenin/RhoA/GDP 0.079 0.092 0.307 9.0 -0.348 2.0 11.0 RAC1/GTP/IQGAP1 0.03 0.021 -9999.0 0.0 -0.27 2.0 2.0 PIP5K1C/AP1M1 0.038 0.026 -9999.0 0.0 -0.578 1.0 1.0 RHOA 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 CDC42 0.022 0.039 -9999.0 0.0 -0.447 4.0 4.0 CTNNA1 0.025 0.028 -9999.0 0.0 -0.447 2.0 2.0 positive regulation of S phase of mitotic cell cycle 0.028 0.051 0.139 40.0 -0.15 6.0 46.0 NME1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.015 0.04 -9999.0 0.0 -0.36 3.0 3.0 regulation of cell-cell adhesion 0.007 0.025 -9999.0 0.0 -0.229 2.0 2.0 WASF2 0.009 0.031 -9999.0 0.0 -0.116 4.0 4.0 Rap1/GTP 0.073 0.076 0.301 4.0 -0.353 1.0 5.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.057 0.06 -9999.0 0.0 -0.23 18.0 18.0 CCND1 0.031 0.059 0.156 39.0 -0.184 6.0 45.0 VAV2 0.05 0.182 0.403 1.0 -0.665 28.0 29.0 RAP1/GDP 0.079 0.087 0.311 8.0 -0.398 1.0 9.0 adherens junction assembly 0.013 0.041 -9999.0 0.0 -0.349 3.0 3.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.026 0.02 -9999.0 0.0 -0.447 1.0 1.0 PIP5K1C 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.042 0.054 -9999.0 0.0 -0.223 18.0 18.0 E-cadherin/beta catenin 0.012 0.02 -9999.0 0.0 -0.298 2.0 2.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC 0.009 0.036 -9999.0 0.0 -0.334 4.0 4.0 PIK3CA 0.025 0.028 -9999.0 0.0 -0.447 2.0 2.0 Rac1/GTP -0.013 0.086 -9999.0 0.0 -0.374 27.0 27.0 E-cadherin/beta catenin/alpha catenin 0.051 0.025 -9999.0 0.0 -0.274 3.0 3.0 ITGAE 0.022 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.025 0.042 -9999.0 0.0 -0.32 6.0 6.0