Nephrin/Neph1 signaling in the kidney podocyte Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations positive regulation of NF-kappaB transcription factor activity -0.006 0.117 0.352 54.0 -9999.0 0.0 54.0 KIRREL -0.001 0.109 -9999.0 0.0 -0.44 33.0 33.0 Nephrin/NEPH1Par3/Par6/Atypical PKCs 0.006 0.117 -9999.0 0.0 -0.353 54.0 54.0 PLCG1 0.015 0.023 -9999.0 0.0 -0.447 1.0 1.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 WASL 0.026 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/CD2AP 0.021 0.12 -9999.0 0.0 -0.278 77.0 77.0 ChemicalAbstracts:57-88-5 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/NCK1-2/N-WASP -0.002 0.085 -9999.0 0.0 -0.26 53.0 53.0 FYN -0.024 0.09 0.206 22.0 -0.253 56.0 78.0 mol:Ca2+ 0.015 0.089 -9999.0 0.0 -0.275 40.0 40.0 mol:DAG 0.016 0.09 -9999.0 0.0 -0.276 40.0 40.0 NPHS2 0.012 0.035 -9999.0 0.0 -0.145 3.0 3.0 mol:IP3 0.016 0.09 -9999.0 0.0 -0.276 40.0 40.0 regulation of endocytosis 0.019 0.09 -9999.0 0.0 -0.238 56.0 56.0 Nephrin/NEPH1/podocin/Cholesterol 0.021 0.095 -9999.0 0.0 -0.265 53.0 53.0 establishment of cell polarity 0.006 0.117 -9999.0 0.0 -0.352 54.0 54.0 Nephrin/NEPH1/podocin/NCK1-2 0.047 0.101 -9999.0 0.0 -0.253 54.0 54.0 Nephrin/NEPH1/beta Arrestin2 0.021 0.091 -9999.0 0.0 -0.241 56.0 56.0 NPHS1 0.002 0.108 -9999.0 0.0 -0.451 29.0 29.0 Nephrin/NEPH1/podocin 0.022 0.094 -9999.0 0.0 -0.255 56.0 56.0 TJP1 0.024 0.02 -9999.0 0.0 -0.447 1.0 1.0 NCK1 0.025 0.027 -9999.0 0.0 -0.447 2.0 2.0 NCK2 0.026 0.019 -9999.0 0.0 -0.447 1.0 1.0 heterophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Nephrin/NEPH1/podocin/PLCgamma1 0.017 0.091 -9999.0 0.0 -0.277 40.0 40.0 CD2AP 0.006 0.097 -9999.0 0.0 -0.447 26.0 26.0 Nephrin/NEPH1/podocin/GRB2 0.035 0.101 -9999.0 0.0 -0.269 53.0 53.0 GRB2 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TRPC6 -0.039 0.102 0.217 21.0 -0.278 67.0 88.0 cytoskeleton organization -0.02 0.095 0.199 5.0 -0.309 51.0 56.0 Nephrin/NEPH1 0.01 0.084 -9999.0 0.0 -0.246 54.0 54.0 Nephrin/NEPH1/ZO-1 0.021 0.102 -9999.0 0.0 -0.285 54.0 54.0