Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.033 0.17 -9999.0 0.0 -0.566 46.0 46.0 IHH -0.011 0.135 -9999.0 0.0 -0.446 46.0 46.0 SHH Np/Cholesterol/GAS1 -0.02 0.112 0.185 3.0 -0.257 103.0 106.0 LRPAP1 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 dorsoventral neural tube patterning 0.02 0.111 0.255 103.0 -0.183 3.0 106.0 SMO/beta Arrestin2 -0.023 0.163 -9999.0 0.0 -0.462 49.0 49.0 SMO -0.037 0.164 -9999.0 0.0 -0.484 49.0 49.0 AKT1 -0.028 0.152 -9999.0 0.0 -0.577 23.0 23.0 ARRB2 0.022 0.01 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.009 0.068 -9999.0 0.0 -0.447 10.0 10.0 ADRBK1 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 heart looping -0.035 0.161 -9999.0 0.0 -0.477 49.0 49.0 STIL -0.024 0.126 -9999.0 0.0 -0.437 28.0 28.0 DHH N/PTCH2 0.006 0.113 -9999.0 0.0 -0.347 52.0 52.0 DHH N/PTCH1 -0.014 0.136 -9999.0 0.0 -0.296 101.0 101.0 PIK3CA 0.025 0.028 -9999.0 0.0 -0.447 2.0 2.0 DHH -0.001 0.105 -9999.0 0.0 -0.447 30.0 30.0 PTHLH -0.06 0.246 -9999.0 0.0 -0.845 45.0 45.0 determination of left/right symmetry -0.035 0.161 -9999.0 0.0 -0.477 49.0 49.0 PIK3R1 0.024 0.028 -9999.0 0.0 -0.447 2.0 2.0 skeletal system development -0.059 0.243 -9999.0 0.0 -0.834 45.0 45.0 IHH N/Hhip -0.025 0.156 -9999.0 0.0 -0.374 93.0 93.0 DHH N/Hhip -0.015 0.143 -9999.0 0.0 -0.352 86.0 86.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.035 0.161 -9999.0 0.0 -0.477 49.0 49.0 pancreas development -0.033 0.148 -9999.0 0.0 -0.446 66.0 66.0 HHAT 0.021 0.051 -9999.0 0.0 -0.447 7.0 7.0 PI3K 0.035 0.031 -9999.0 0.0 -0.322 4.0 4.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.053 0.159 -9999.0 0.0 -0.447 78.0 78.0 somite specification -0.035 0.161 -9999.0 0.0 -0.477 49.0 49.0 SHH Np/Cholesterol/PTCH1 -0.023 0.127 -9999.0 0.0 -0.337 62.0 62.0 SHH Np/Cholesterol/PTCH2 -0.003 0.084 -9999.0 0.0 -0.259 54.0 54.0 SHH Np/Cholesterol/Megalin 0.009 0.065 0.184 1.0 -0.252 33.0 34.0 SHH -0.007 0.075 0.233 1.0 -0.322 31.0 32.0 catabolic process -0.019 0.125 -9999.0 0.0 -0.325 78.0 78.0 SMO/Vitamin D3 -0.031 0.152 -9999.0 0.0 -0.389 71.0 71.0 SHH Np/Cholesterol/Hhip -0.018 0.109 0.185 2.0 -0.271 86.0 88.0 LRP2 0.014 0.032 -9999.0 0.0 -9999.0 0.0 0.0 receptor-mediated endocytosis -0.035 0.148 -9999.0 0.0 -0.511 33.0 33.0 SHH Np/Cholesterol/BOC 0.008 0.074 0.185 2.0 -0.26 39.0 41.0 SHH Np/Cholesterol/CDO 0.006 0.069 -9999.0 0.0 -0.26 36.0 36.0 mesenchymal cell differentiation 0.018 0.108 0.269 86.0 -0.183 2.0 88.0 mol:Vitamin D3 -0.015 0.136 0.365 1.0 -0.34 61.0 62.0 IHH N/PTCH2 -0.003 0.122 -9999.0 0.0 -0.335 64.0 64.0 CDON 0.02 0.049 -9999.0 0.0 -0.447 6.0 6.0 IHH N/PTCH1 -0.009 0.13 -9999.0 0.0 -0.328 78.0 78.0 Megalin/LRPAP1 0.039 0.022 -9999.0 0.0 -0.325 1.0 1.0 PTCH2 0.002 0.1 -9999.0 0.0 -0.447 27.0 27.0 SHH Np/Cholesterol -0.001 0.059 -9999.0 0.0 -0.243 33.0 33.0 PTCH1 -0.019 0.126 -9999.0 0.0 -0.326 78.0 78.0 HHIP -0.033 0.149 -9999.0 0.0 -0.447 66.0 66.0