Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.018 0.034 -9999.0 0.0 -0.232 10.0 10.0 epithelial cell differentiation 0.053 0.025 -9999.0 0.0 -0.234 3.0 3.0 CYFIP2 0.018 0.061 -9999.0 0.0 -0.447 10.0 10.0 ENAH -0.024 0.05 0.267 2.0 -0.387 4.0 6.0 EGFR 0.021 0.04 -9999.0 0.0 -0.447 4.0 4.0 EPHA2 0.023 0.029 -9999.0 0.0 -0.447 2.0 2.0 MYO6 -0.015 0.021 0.173 3.0 -0.227 3.0 6.0 CTNNB1 0.026 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.046 0.051 -9999.0 0.0 -0.293 12.0 12.0 AQP5 -0.009 0.097 -9999.0 0.0 -0.45 26.0 26.0 CTNND1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.014 0.025 0.172 5.0 -0.224 4.0 9.0 regulation of calcium-dependent cell-cell adhesion -0.029 0.059 0.18 5.0 -0.231 40.0 45.0 EGF -0.069 0.163 -9999.0 0.0 -0.447 86.0 86.0 NCKAP1 0.025 0.027 -9999.0 0.0 -0.447 2.0 2.0 AQP3 0.005 0.057 -9999.0 0.0 -0.44 8.0 8.0 cortical microtubule organization 0.053 0.025 -9999.0 0.0 -0.234 3.0 3.0 GO:0000145 -0.014 0.023 0.159 5.0 -0.214 4.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.059 0.026 -9999.0 0.0 -0.236 3.0 3.0 MLLT4 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 ARF6/GDP -0.025 0.029 -9999.0 0.0 -0.273 6.0 6.0 ARF6 0.024 0.02 -9999.0 0.0 -0.447 1.0 1.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.039 -9999.0 0.0 -0.306 4.0 4.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.004 0.02 -9999.0 0.0 -0.23 1.0 1.0 PVRL2 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 ZYX -0.015 0.02 0.173 1.0 -0.228 4.0 5.0 ARF6/GTP 0.061 0.044 -9999.0 0.0 -0.336 4.0 4.0 CDH1 0.026 0.02 -9999.0 0.0 -0.447 1.0 1.0 EGFR/EGFR/EGF/EGF 0.009 0.097 -9999.0 0.0 -0.224 82.0 82.0 RhoA/GDP 0.053 0.027 -9999.0 0.0 -0.226 4.0 4.0 actin cytoskeleton organization -0.016 0.022 0.16 2.0 -0.219 5.0 7.0 IGF-1R heterotetramer 0.025 0.02 -9999.0 0.0 -0.446 1.0 1.0 GIT1 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 IGF1R 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 IGF1 -0.024 0.135 -9999.0 0.0 -0.447 52.0 52.0 DIAPH1 0.028 0.133 -9999.0 0.0 -0.58 23.0 23.0 Wnt receptor signaling pathway -0.053 0.025 0.234 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.02 -9999.0 0.0 -0.447 1.0 1.0 RhoA/GTP -0.026 0.029 -9999.0 0.0 -0.264 7.0 7.0 CTNNA1 0.025 0.028 -9999.0 0.0 -0.447 2.0 2.0 VCL -0.016 0.022 0.162 2.0 -0.223 5.0 7.0 EFNA1 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.025 0.164 5.0 -0.221 4.0 9.0 Ephrin A1/EPHA2 0.044 0.031 -9999.0 0.0 -0.224 5.0 5.0 SEC6/SEC8 -0.023 0.02 -9999.0 0.0 -0.218 5.0 5.0 MGAT3 -0.029 0.059 0.182 5.0 -0.234 40.0 45.0 HGF/MET 0.031 0.068 -9999.0 0.0 -0.223 37.0 37.0 HGF -0.005 0.111 -9999.0 0.0 -0.447 34.0 34.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.018 0.034 -9999.0 0.0 -0.234 10.0 10.0 actin cable formation -0.008 0.072 0.236 16.0 -0.313 8.0 24.0 KIAA1543 -0.014 0.024 0.161 5.0 -0.217 4.0 9.0 KIFC3 -0.018 0.029 0.173 1.0 -0.229 10.0 11.0 NCK1 0.025 0.027 -9999.0 0.0 -0.447 2.0 2.0 EXOC3 0.026 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.014 0.024 0.173 5.0 -0.227 3.0 8.0 NCK1/GIT1 0.036 0.027 -9999.0 0.0 -0.321 3.0 3.0 mol:GDP 0.053 0.025 -9999.0 0.0 -0.234 3.0 3.0 EXOC4 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.015 0.02 0.173 2.0 -0.227 3.0 5.0 PIP5K1C -0.014 0.025 0.173 5.0 -0.228 4.0 9.0 LIMA1 0.021 0.051 -9999.0 0.0 -0.447 7.0 7.0 ABI1 0.026 0.02 -9999.0 0.0 -0.447 1.0 1.0 ROCK1 -0.018 0.051 0.287 4.0 -0.429 2.0 6.0 adherens junction assembly -0.005 0.059 0.268 4.0 -0.383 7.0 11.0 IGF-1R heterotetramer/IGF1 0.025 0.081 -9999.0 0.0 -0.226 53.0 53.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.037 0.022 -9999.0 0.0 -0.321 2.0 2.0 MET 0.025 0.021 -9999.0 0.0 -0.447 1.0 1.0 PLEKHA7 -0.015 0.025 0.173 5.0 -0.228 4.0 9.0 mol:GTP 0.056 0.038 -9999.0 0.0 -0.304 4.0 4.0 establishment of epithelial cell apical/basal polarity -0.014 0.051 0.314 3.0 -9999.0 0.0 3.0 cortical actin cytoskeleton stabilization 0.018 0.034 -9999.0 0.0 -0.232 10.0 10.0 regulation of cell-cell adhesion -0.016 0.022 0.16 2.0 -0.219 5.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.018 0.034 -9999.0 0.0 -0.234 10.0 10.0