E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.001 0.164 -9999.0 0.0 -0.541 17.0 17.0 KLHL20 -0.039 0.08 -9999.0 0.0 -0.282 8.0 8.0 CYFIP2 -0.016 0.139 -9999.0 0.0 -0.597 12.0 12.0 Rac1/GDP 0.022 0.123 -9999.0 0.0 -0.493 6.0 6.0 ENAH -0.015 0.175 -9999.0 0.0 -0.57 16.0 16.0 AP1M1 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 RAP1B 0.015 0.042 -9999.0 0.0 -0.609 1.0 1.0 RAP1A 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 CTNNB1 -0.016 0.131 -9999.0 0.0 -0.517 14.0 14.0 CDC42/GTP -0.029 0.087 -9999.0 0.0 -0.425 7.0 7.0 ABI1/Sra1/Nap1 -0.034 0.06 -9999.0 0.0 -0.203 13.0 13.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.021 0.14 -9999.0 0.0 -0.335 31.0 31.0 RAPGEF1 0.014 0.151 -9999.0 0.0 -0.482 16.0 16.0 CTNND1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.01 0.167 -9999.0 0.0 -0.575 16.0 16.0 CRK 0.005 0.164 -9999.0 0.0 -0.537 16.0 16.0 E-cadherin/gamma catenin/alpha catenin 0.014 0.09 -9999.0 0.0 -0.368 11.0 11.0 alphaE/beta7 Integrin -0.01 0.123 -9999.0 0.0 -0.421 18.0 18.0 IQGAP1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 -0.006 0.107 -9999.0 0.0 -0.494 10.0 10.0 Rap1/GTP/I-afadin 0.019 0.071 -9999.0 0.0 -0.336 8.0 8.0 DLG1 -0.002 0.163 -9999.0 0.0 -0.551 16.0 16.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.022 0.063 -9999.0 0.0 -0.298 7.0 7.0 MLLT4 -0.002 0.109 -9999.0 0.0 -0.609 7.0 7.0 ARF6/GTP/NME1/Tiam1 0.019 0.078 -9999.0 0.0 -0.383 7.0 7.0 PI3K -0.028 0.084 -9999.0 0.0 -0.403 7.0 7.0 ARF6 0.003 0.093 -9999.0 0.0 -0.609 5.0 5.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.001 0.104 -9999.0 0.0 -0.431 12.0 12.0 TIAM1 0.01 0.067 -9999.0 0.0 -0.561 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.006 0.104 -9999.0 0.0 -0.323 16.0 16.0 AKT1 -0.018 0.05 -9999.0 0.0 -0.223 6.0 6.0 PIK3R1 0.009 0.072 -9999.0 0.0 -0.609 3.0 3.0 CDH1 -0.014 0.136 -9999.0 0.0 -0.609 11.0 11.0 RhoA/GDP 0.022 0.122 -9999.0 0.0 -0.493 6.0 6.0 actin cytoskeleton organization 0.014 0.081 -9999.0 0.0 -0.201 8.0 8.0 CDC42/GDP 0.021 0.124 -9999.0 0.0 -0.476 7.0 7.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.065 -9999.0 0.0 -0.266 11.0 11.0 ITGB7 -0.022 0.152 -9999.0 0.0 -0.609 14.0 14.0 RAC1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.008 0.111 -9999.0 0.0 -0.342 16.0 16.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.004 0.104 -9999.0 0.0 -0.331 16.0 16.0 mol:GDP 0.011 0.143 -9999.0 0.0 -0.61 6.0 6.0 CDC42/GTP/IQGAP1 0.022 0.02 -9999.0 0.0 -0.27 1.0 1.0 JUP 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 p120 catenin/RhoA/GDP 0.018 0.123 -9999.0 0.0 -0.503 6.0 6.0 RAC1/GTP/IQGAP1 0.024 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.024 0.031 -9999.0 0.0 -0.441 1.0 1.0 RHOA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.015 0.032 -9999.0 0.0 -0.466 1.0 1.0 CTNNA1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.012 0.065 -9999.0 0.0 -0.206 8.0 8.0 NME1 0.015 0.042 -9999.0 0.0 -0.608 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.002 0.163 -9999.0 0.0 -0.551 16.0 16.0 regulation of cell-cell adhesion -0.026 0.076 -9999.0 0.0 -0.364 7.0 7.0 WASF2 -0.02 0.035 -9999.0 0.0 -0.235 1.0 1.0 Rap1/GTP -0.033 0.099 -9999.0 0.0 -0.503 6.0 6.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.006 0.116 -9999.0 0.0 -9999.0 0.0 0.0 CCND1 0.013 0.079 -9999.0 0.0 -0.257 8.0 8.0 VAV2 -0.055 0.265 -9999.0 0.0 -0.725 25.0 25.0 RAP1/GDP 0.023 0.121 -9999.0 0.0 -0.509 6.0 6.0 adherens junction assembly -0.0 0.157 -9999.0 0.0 -0.53 16.0 16.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.003 0.128 -9999.0 0.0 -0.505 1.0 1.0 E-cadherin/beta catenin -0.024 0.088 -9999.0 0.0 -0.4 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.005 0.175 -9999.0 0.0 -0.586 16.0 16.0 PIK3CA 0.017 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.065 0.134 -9999.0 0.0 -0.393 23.0 23.0 E-cadherin/beta catenin/alpha catenin -0.005 0.12 -9999.0 0.0 -0.384 16.0 16.0 ITGAE 0.008 0.07 -9999.0 0.0 -0.502 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.011 0.171 -9999.0 0.0 -0.591 16.0 16.0