E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.006 0.141 -9999.0 0.0 -0.498 15.0 15.0 KLHL20 0.029 0.117 0.222 10.0 -0.25 18.0 28.0 CYFIP2 0.012 0.107 -9999.0 0.0 -0.444 11.0 11.0 Rac1/GDP 0.049 0.139 0.3 5.0 -0.427 6.0 11.0 ENAH -0.016 0.147 -9999.0 0.0 -0.512 15.0 15.0 AP1M1 0.034 0.035 -9999.0 0.0 -0.469 1.0 1.0 RAP1B 0.034 0.035 -9999.0 0.0 -0.469 1.0 1.0 RAP1A 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.017 0.081 -9999.0 0.0 -0.277 13.0 13.0 CDC42/GTP 0.037 0.1 -9999.0 0.0 -0.354 6.0 6.0 ABI1/Sra1/Nap1 -0.028 0.057 -9999.0 0.0 -0.18 21.0 21.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.02 0.122 -9999.0 0.0 -0.263 28.0 28.0 RAPGEF1 0.032 0.153 0.347 2.0 -0.485 11.0 13.0 CTNND1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.002 0.146 -9999.0 0.0 -0.51 15.0 15.0 CRK 0.029 0.16 -9999.0 0.0 -0.528 11.0 11.0 E-cadherin/gamma catenin/alpha catenin 0.052 0.078 -9999.0 0.0 -0.288 10.0 10.0 alphaE/beta7 Integrin 0.017 0.097 -9999.0 0.0 -0.333 14.0 14.0 IQGAP1 0.034 0.009 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.024 0.064 -9999.0 0.0 -0.247 10.0 10.0 Rap1/GTP/I-afadin 0.055 0.058 -9999.0 0.0 -0.26 6.0 6.0 DLG1 -0.007 0.141 -9999.0 0.0 -0.498 15.0 15.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.011 0.054 -9999.0 0.0 -0.262 6.0 6.0 MLLT4 0.024 0.076 -9999.0 0.0 -0.469 5.0 5.0 ARF6/GTP/NME1/Tiam1 0.05 0.058 -9999.0 0.0 -0.271 5.0 5.0 PI3K -0.01 0.073 -9999.0 0.0 -0.348 6.0 6.0 ARF6 0.029 0.049 -9999.0 0.0 -0.469 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.033 0.084 -9999.0 0.0 -0.338 10.0 10.0 TIAM1 0.029 0.051 -9999.0 0.0 -0.377 3.0 3.0 E-cadherin(dimer)/Ca2+ 0.053 0.09 -9999.0 0.0 -0.252 14.0 14.0 AKT1 0.028 0.067 0.194 3.0 -0.202 5.0 8.0 PIK3R1 0.029 0.06 -9999.0 0.0 -0.469 3.0 3.0 CDH1 0.012 0.107 -9999.0 0.0 -0.469 10.0 10.0 RhoA/GDP 0.062 0.145 0.334 6.0 -0.426 6.0 12.0 actin cytoskeleton organization 0.03 0.096 0.211 13.0 -0.181 18.0 31.0 CDC42/GDP 0.058 0.146 0.33 7.0 -0.426 6.0 13.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.016 0.055 -9999.0 0.0 -0.228 10.0 10.0 ITGB7 0.003 0.125 -9999.0 0.0 -0.469 14.0 14.0 RAC1 0.033 0.011 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.058 0.096 -9999.0 0.0 -0.268 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.036 0.082 -9999.0 0.0 -0.25 14.0 14.0 mol:GDP 0.048 0.158 0.348 6.0 -0.482 7.0 13.0 CDC42/GTP/IQGAP1 0.043 0.02 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.034 0.017 -9999.0 0.0 -0.191 1.0 1.0 p120 catenin/RhoA/GDP 0.07 0.151 0.356 5.0 -0.437 6.0 11.0 RAC1/GTP/IQGAP1 0.042 0.018 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.051 0.028 -9999.0 0.0 -0.338 1.0 1.0 RHOA 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.033 0.018 -9999.0 0.0 -0.191 1.0 1.0 CTNNA1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.028 0.075 0.175 16.0 -0.179 4.0 20.0 NME1 0.033 0.035 -9999.0 0.0 -0.469 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.009 0.141 -9999.0 0.0 -0.498 15.0 15.0 regulation of cell-cell adhesion -0.002 0.066 -9999.0 0.0 -0.307 6.0 6.0 WASF2 0.01 0.051 0.11 9.0 -0.143 3.0 12.0 Rap1/GTP 0.068 0.125 0.323 2.0 -0.403 6.0 8.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.044 0.114 -9999.0 0.0 -0.247 23.0 23.0 CCND1 0.031 0.088 0.203 15.0 -0.207 5.0 20.0 VAV2 0.003 0.286 0.415 1.0 -0.718 23.0 24.0 RAP1/GDP 0.072 0.137 0.349 4.0 -0.416 6.0 10.0 adherens junction assembly -0.008 0.136 -9999.0 0.0 -0.481 15.0 15.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.036 0.006 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.017 0.112 -9999.0 0.0 -0.277 2.0 2.0 E-cadherin/beta catenin -0.002 0.079 -9999.0 0.0 -0.331 11.0 11.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.019 0.138 -9999.0 0.0 -0.563 11.0 11.0 PIK3CA 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.043 0.132 -9999.0 0.0 -0.389 23.0 23.0 E-cadherin/beta catenin/alpha catenin 0.04 0.096 -9999.0 0.0 -0.294 14.0 14.0 ITGAE 0.028 0.026 -9999.0 0.0 -0.191 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.001 0.15 -9999.0 0.0 -0.523 15.0 15.0