Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.01 0.073 -9999.0 0.0 -0.224 17.0 17.0 epithelial cell differentiation 0.047 0.087 -9999.0 0.0 -0.25 14.0 14.0 CYFIP2 0.012 0.107 -9999.0 0.0 -0.444 11.0 11.0 ENAH -0.039 0.081 0.279 1.0 -0.346 5.0 6.0 EGFR 0.017 0.086 -9999.0 0.0 -0.4 8.0 8.0 EPHA2 0.013 0.083 -9999.0 0.0 -0.265 15.0 15.0 MYO6 -0.007 0.074 -9999.0 0.0 -0.24 18.0 18.0 CTNNB1 0.017 0.081 -9999.0 0.0 -0.277 13.0 13.0 ABI1/Sra1/Nap1 0.047 0.088 -9999.0 0.0 -0.295 11.0 11.0 AQP5 -0.01 0.091 -9999.0 0.0 -0.488 4.0 4.0 CTNND1 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.001 0.069 -9999.0 0.0 -0.238 14.0 14.0 regulation of calcium-dependent cell-cell adhesion -0.034 0.094 -9999.0 0.0 -0.239 32.0 32.0 EGF -0.088 0.183 -9999.0 0.0 -0.305 78.0 78.0 NCKAP1 0.024 0.064 -9999.0 0.0 -0.247 10.0 10.0 AQP3 -0.024 0.109 -9999.0 0.0 -0.452 8.0 8.0 cortical microtubule organization 0.047 0.087 -9999.0 0.0 -0.25 14.0 14.0 GO:0000145 -0.024 0.06 0.166 3.0 -0.228 14.0 17.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.053 0.09 -9999.0 0.0 -0.252 14.0 14.0 MLLT4 0.024 0.076 -9999.0 0.0 -0.469 5.0 5.0 ARF6/GDP -0.049 0.085 -9999.0 0.0 -0.355 8.0 8.0 ARF6 0.029 0.049 -9999.0 0.0 -0.469 2.0 2.0 Ephrin A1/EPHA2/NCK1/GIT1 0.048 0.097 -9999.0 0.0 -0.276 12.0 12.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.014 0.071 -9999.0 0.0 -0.315 3.0 3.0 PVRL2 0.032 0.041 -9999.0 0.0 -0.284 3.0 3.0 ZYX -0.006 0.07 -9999.0 0.0 -0.24 16.0 16.0 ARF6/GTP 0.048 0.102 -9999.0 0.0 -0.265 14.0 14.0 CDH1 0.012 0.107 -9999.0 0.0 -0.469 10.0 10.0 EGFR/EGFR/EGF/EGF -0.037 0.133 -9999.0 0.0 -0.261 44.0 44.0 RhoA/GDP 0.049 0.085 -9999.0 0.0 -0.239 14.0 14.0 actin cytoskeleton organization -0.016 0.068 -9999.0 0.0 -0.238 14.0 14.0 IGF-1R heterotetramer 0.031 0.039 -9999.0 0.0 -0.33 2.0 2.0 GIT1 0.034 0.017 -9999.0 0.0 -0.191 1.0 1.0 IGF1R 0.031 0.039 -9999.0 0.0 -0.33 2.0 2.0 IGF1 0.017 0.078 -9999.0 0.0 -0.247 15.0 15.0 DIAPH1 0.028 0.18 -9999.0 0.0 -0.62 14.0 14.0 Wnt receptor signaling pathway -0.047 0.087 0.25 14.0 -9999.0 0.0 14.0 RHOA 0.036 0.005 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.047 0.083 -9999.0 0.0 -0.387 6.0 6.0 CTNNA1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.016 0.069 -9999.0 0.0 -0.243 14.0 14.0 EFNA1 0.022 0.075 -9999.0 0.0 -0.33 8.0 8.0 LPP -0.025 0.061 0.173 3.0 -0.297 1.0 4.0 Ephrin A1/EPHA2 0.019 0.112 -9999.0 0.0 -0.291 19.0 19.0 SEC6/SEC8 -0.009 0.085 -9999.0 0.0 -0.362 7.0 7.0 MGAT3 -0.035 0.096 -9999.0 0.0 -0.242 32.0 32.0 HGF/MET 0.035 0.091 -9999.0 0.0 -0.255 15.0 15.0 HGF 0.033 0.023 -9999.0 0.0 -0.191 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.01 0.073 -9999.0 0.0 -0.226 17.0 17.0 actin cable formation -0.018 0.103 0.327 5.0 -0.305 7.0 12.0 KIAA1543 -0.024 0.06 0.167 3.0 -0.231 14.0 17.0 KIFC3 -0.006 0.07 -9999.0 0.0 -0.241 15.0 15.0 NCK1 0.027 0.068 -9999.0 0.0 -0.469 4.0 4.0 EXOC3 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.002 0.069 -9999.0 0.0 -0.242 14.0 14.0 NCK1/GIT1 0.043 0.055 -9999.0 0.0 -0.338 4.0 4.0 mol:GDP 0.047 0.087 -9999.0 0.0 -0.25 14.0 14.0 EXOC4 0.035 0.009 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.004 0.068 -9999.0 0.0 -0.241 15.0 15.0 PIP5K1C -0.001 0.07 -9999.0 0.0 -0.242 14.0 14.0 LIMA1 0.025 0.072 -9999.0 0.0 -0.377 6.0 6.0 ABI1 0.036 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.031 0.09 0.301 3.0 -0.386 4.0 7.0 adherens junction assembly -0.006 0.071 0.27 3.0 -0.315 1.0 4.0 IGF-1R heterotetramer/IGF1 0.025 0.094 -9999.0 0.0 -0.243 18.0 18.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.039 0.067 -9999.0 0.0 -0.338 6.0 6.0 MET 0.028 0.053 -9999.0 0.0 -0.33 4.0 4.0 PLEKHA7 -0.001 0.07 -9999.0 0.0 -0.242 14.0 14.0 mol:GTP 0.046 0.095 -9999.0 0.0 -0.274 12.0 12.0 establishment of epithelial cell apical/basal polarity -0.024 0.093 0.329 1.0 -0.367 6.0 7.0 cortical actin cytoskeleton stabilization 0.01 0.073 -9999.0 0.0 -0.224 17.0 17.0 regulation of cell-cell adhesion -0.016 0.068 -9999.0 0.0 -0.238 14.0 14.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.01 0.073 -9999.0 0.0 -0.226 17.0 17.0