Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.017 0.123 -9999.0 0.0 -0.327 3.0 3.0 epithelial cell differentiation 0.011 0.105 -9999.0 0.0 -0.234 4.0 4.0 CYFIP2 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.007 0.098 0.433 1.0 -9999.0 0.0 1.0 EGFR -0.007 0.125 -9999.0 0.0 -0.456 2.0 2.0 EPHA2 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 MYO6 -0.008 0.096 0.183 2.0 -0.213 4.0 6.0 CTNNB1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.05 0.064 -9999.0 0.0 -0.276 1.0 1.0 AQP5 -0.004 0.06 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.008 0.099 0.184 2.0 -0.222 4.0 6.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.125 0.18 1.0 -0.258 6.0 7.0 EGF 0.022 0.008 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.014 0.091 -9999.0 0.0 -0.456 1.0 1.0 AQP3 -0.011 0.109 -9999.0 0.0 -0.45 1.0 1.0 cortical microtubule organization 0.011 0.105 -9999.0 0.0 -0.234 4.0 4.0 GO:0000145 -0.024 0.09 0.173 2.0 -0.213 4.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.015 0.108 -9999.0 0.0 -0.236 4.0 4.0 MLLT4 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.036 0.069 -9999.0 0.0 -0.204 4.0 4.0 ARF6 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.07 0.028 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.01 0.075 0.192 1.0 -9999.0 0.0 1.0 PVRL2 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.007 0.084 0.19 1.0 -0.225 3.0 4.0 ARF6/GTP 0.077 0.031 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.042 0.169 -9999.0 0.0 -0.456 4.0 4.0 EGFR/EGFR/EGF/EGF -0.006 0.119 -9999.0 0.0 -0.274 4.0 4.0 RhoA/GDP 0.011 0.101 -9999.0 0.0 -0.223 4.0 4.0 actin cytoskeleton organization -0.013 0.091 0.171 2.0 -0.206 4.0 6.0 IGF-1R heterotetramer 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 -0.004 0.126 -9999.0 0.0 -0.456 2.0 2.0 DIAPH1 0.029 0.126 -9999.0 0.0 -9999.0 0.0 0.0 Wnt receptor signaling pathway -0.011 0.105 0.234 4.0 -9999.0 0.0 4.0 RHOA 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.036 0.069 -9999.0 0.0 -0.206 4.0 4.0 CTNNA1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.014 0.092 0.172 2.0 -0.211 4.0 6.0 EFNA1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.023 0.077 0.188 1.0 -0.217 3.0 4.0 Ephrin A1/EPHA2 0.009 0.097 -9999.0 0.0 -0.22 4.0 4.0 SEC6/SEC8 -0.005 0.056 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.04 0.126 0.181 1.0 -0.262 6.0 7.0 HGF/MET 0.005 0.101 -9999.0 0.0 -0.232 4.0 4.0 HGF 0.01 0.09 -9999.0 0.0 -0.456 1.0 1.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.017 0.124 -9999.0 0.0 -0.33 3.0 3.0 actin cable formation 0.02 0.112 0.522 1.0 -9999.0 0.0 1.0 KIAA1543 -0.039 0.104 0.175 2.0 -0.216 6.0 8.0 KIFC3 -0.022 0.1 0.181 1.0 -0.226 5.0 6.0 NCK1 0.029 0.008 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.008 0.1 0.186 2.0 -0.225 4.0 6.0 NCK1/GIT1 0.044 0.012 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.011 0.105 -9999.0 0.0 -0.234 4.0 4.0 EXOC4 0.028 0.01 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.008 0.1 0.186 2.0 -0.225 4.0 6.0 PIP5K1C -0.008 0.1 0.186 2.0 -0.225 4.0 6.0 LIMA1 0.012 0.09 -9999.0 0.0 -0.456 1.0 1.0 ABI1 0.03 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 0.007 0.12 0.357 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.066 0.172 -9999.0 0.0 -0.578 2.0 2.0 IGF-1R heterotetramer/IGF1 -0.009 0.126 -9999.0 0.0 -0.262 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.016 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.008 0.125 -9999.0 0.0 -0.456 2.0 2.0 PLEKHA7 -0.026 0.114 0.186 2.0 -0.226 6.0 8.0 mol:GTP 0.067 0.028 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity -0.001 0.09 0.322 1.0 -9999.0 0.0 1.0 cortical actin cytoskeleton stabilization -0.017 0.123 -9999.0 0.0 -0.327 3.0 3.0 regulation of cell-cell adhesion -0.013 0.091 0.171 2.0 -0.206 4.0 6.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.017 0.124 -9999.0 0.0 -0.33 3.0 3.0