Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
IL4-mediated signaling events	8.0	741.0	91.0	-0.875	0.82	1000.0	-1000.0	-0.083	-1000.0
IL23-mediated signaling events	6.0	361.0	60.0	-0.46	0.043	1000.0	-1000.0	-0.069	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	3.0	108.0	34.0	-0.073	0.032	1000.0	-1000.0	-0.022	-1000.0
Syndecan-1-mediated signaling events	3.0	104.0	34.0	-0.098	0.032	1000.0	-1000.0	-0.023	-1000.0
Osteopontin-mediated events	3.0	127.0	38.0	-0.179	0.045	1000.0	-1000.0	-0.026	-1000.0
HIF-1-alpha transcription factor network	3.0	266.0	76.0	-0.151	0.041	1000.0	-1000.0	-0.03	-1000.0
p75(NTR)-mediated signaling	3.0	397.0	125.0	-0.113	0.077	1000.0	-1000.0	-0.033	-1000.0
Arf6 downstream pathway	3.0	148.0	43.0	-0.157	0.055	1000.0	-1000.0	-0.027	-1000.0
Glucocorticoid receptor regulatory network	3.0	391.0	114.0	-0.387	0.287	1000.0	-1000.0	-0.039	-1000.0
Signaling events regulated by Ret tyrosine kinase	3.0	323.0	82.0	-0.128	0.032	1000.0	-1000.0	-0.035	-1000.0
Endothelins	3.0	331.0	96.0	-0.154	0.032	1000.0	-1000.0	-0.036	-1000.0
Signaling mediated by p38-alpha and p38-beta	3.0	148.0	44.0	-0.1	0.032	1000.0	-1000.0	-0.018	-1000.0
TCR signaling in naïve CD8+ T cells	3.0	284.0	93.0	-0.126	0.08	1000.0	-1000.0	-0.033	-1000.0
ErbB2/ErbB3 signaling events	2.0	151.0	65.0	-0.111	0.043	1000.0	-1000.0	-0.047	-1000.0
Caspase cascade in apoptosis	2.0	176.0	74.0	-0.109	0.07	1000.0	-1000.0	-0.029	-1000.0
IL12-mediated signaling events	2.0	236.0	87.0	-0.245	0.095	1000.0	-1000.0	-0.045	-1000.0
Ephrin A  reverse signaling	2.0	16.0	7.0	-0.024	0.02	1000.0	-1000.0	0.0	-1000.0
Thromboxane A2 receptor signaling	2.0	244.0	105.0	-0.094	0.037	1000.0	-1000.0	-0.028	-1000.0
amb2 Integrin signaling	2.0	207.0	82.0	-0.149	0.051	1000.0	-1000.0	-0.015	-1000.0
Integrins in angiogenesis	2.0	191.0	84.0	-0.092	0.055	1000.0	-1000.0	-0.034	-1000.0
Calcium signaling in the CD4+ TCR pathway	2.0	67.0	31.0	-0.145	0.032	1000.0	-1000.0	-0.03	-1000.0
LPA receptor mediated events	2.0	252.0	102.0	-0.122	0.032	1000.0	-1000.0	-0.055	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	2.0	182.0	74.0	-0.066	0.077	1000.0	-1000.0	-0.051	-1000.0
TCGA08_retinoblastoma	2.0	17.0	8.0	-0.03	0.037	1000.0	-1000.0	-0.005	-1000.0
Angiopoietin receptor Tie2-mediated signaling	2.0	180.0	88.0	-0.128	0.044	1000.0	-1000.0	-0.05	-1000.0
S1P4 pathway	2.0	52.0	25.0	-0.067	0.037	1000.0	-1000.0	-0.017	-1000.0
E-cadherin signaling events	2.0	14.0	5.0	-0.042	0.03	1000.0	-1000.0	0.016	-1000.0
LPA4-mediated signaling events	1.0	17.0	12.0	-0.046	0.0	1000.0	-1000.0	-0.01	-1000.0
BARD1 signaling events	1.0	93.0	57.0	-0.041	0.057	1000.0	-1000.0	-0.038	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	1.0	59.0	54.0	-0.041	0.045	1000.0	-1000.0	-0.012	-1000.0
Signaling events mediated by the Hedgehog family	1.0	91.0	52.0	-0.077	0.043	1000.0	-1000.0	-0.023	-1000.0
Noncanonical Wnt signaling pathway	1.0	37.0	26.0	-0.058	0.032	1000.0	-1000.0	-0.022	-1000.0
Syndecan-2-mediated signaling events	1.0	79.0	69.0	-0.093	0.065	1000.0	-1000.0	-0.022	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	-0.004	0.03	1000.0	-1000.0	0.018	-1000.0
Cellular roles of Anthrax toxin	1.0	50.0	39.0	-0.039	0.032	1000.0	-1000.0	-0.015	-1000.0
Arf6 signaling events	1.0	87.0	62.0	-0.039	0.07	1000.0	-1000.0	-0.035	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	1.0	153.0	85.0	-0.069	0.04	1000.0	-1000.0	-0.037	-1000.0
Presenilin action in Notch and Wnt signaling	1.0	94.0	61.0	-0.108	0.078	1000.0	-1000.0	-0.039	-1000.0
BMP receptor signaling	1.0	150.0	81.0	-0.109	0.057	1000.0	-1000.0	-0.025	-1000.0
Glypican 1 network	1.0	65.0	48.0	-0.148	0.062	1000.0	-1000.0	-0.021	-1000.0
Fc-epsilon receptor I signaling in mast cells	1.0	144.0	97.0	-0.044	0.037	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	1.0	58.0	53.0	-0.056	0.057	1000.0	-1000.0	-0.024	-1000.0
IFN-gamma pathway	1.0	69.0	68.0	-0.09	0.045	1000.0	-1000.0	-0.043	-1000.0
Nectin adhesion pathway	1.0	106.0	63.0	-0.065	0.05	1000.0	-1000.0	-0.038	-1000.0
Ceramide signaling pathway	1.0	102.0	76.0	-0.045	0.055	1000.0	-1000.0	-0.023	-1000.0
Reelin signaling pathway	1.0	76.0	56.0	-0.043	0.062	1000.0	-1000.0	-0.022	-1000.0
IL1-mediated signaling events	1.0	64.0	62.0	-0.038	0.058	1000.0	-1000.0	-0.019	-1000.0
S1P5 pathway	1.0	22.0	17.0	-0.041	0.037	1000.0	-1000.0	-0.005	-1000.0
Ephrin B reverse signaling	1.0	84.0	48.0	-0.077	0.046	1000.0	-1000.0	-0.027	-1000.0
S1P1 pathway	1.0	56.0	36.0	-0.107	0.031	1000.0	-1000.0	-0.024	-1000.0
TCGA08_p53	1.0	8.0	7.0	-0.018	0.03	1000.0	-1000.0	-0.007	-1000.0
FAS signaling pathway (CD95)	1.0	59.0	47.0	-0.091	0.044	1000.0	-1000.0	-0.033	-1000.0
Signaling mediated by p38-gamma and p38-delta	1.0	17.0	15.0	-0.033	0.032	1000.0	-1000.0	-0.018	-1000.0
Canonical Wnt signaling pathway	1.0	90.0	51.0	-0.181	0.045	1000.0	-1000.0	-0.029	-1000.0
EPHB forward signaling	1.0	116.0	85.0	-0.128	0.06	1000.0	-1000.0	-0.037	-1000.0
Effects of Botulinum toxin	1.0	31.0	26.0	-0.038	0.032	1000.0	-1000.0	-0.004	-1000.0
Nongenotropic Androgen signaling	1.0	56.0	52.0	-0.086	0.051	1000.0	-1000.0	-0.019	-1000.0
IL27-mediated signaling events	1.0	79.0	51.0	-0.127	0.051	1000.0	-1000.0	-0.06	-1000.0
Wnt signaling	1.0	12.0	7.0	-0.039	0.032	1000.0	-1000.0	-0.003	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	1.0	100.0	68.0	-0.221	0.038	1000.0	-1000.0	-0.054	-1000.0
E-cadherin signaling in the nascent adherens junction	1.0	125.0	76.0	-0.053	0.057	1000.0	-1000.0	-0.042	-1000.0
BCR signaling pathway	1.0	147.0	99.0	-0.07	0.051	1000.0	-1000.0	-0.034	-1000.0
EGFR-dependent Endothelin signaling events	1.0	23.0	21.0	-0.023	0.044	1000.0	-1000.0	-0.025	-1000.0
Syndecan-4-mediated signaling events	1.0	118.0	67.0	-0.125	0.044	1000.0	-1000.0	-0.025	-1000.0
IGF1 pathway	1.0	82.0	57.0	-0.026	0.062	1000.0	-1000.0	-0.025	-1000.0
Plasma membrane estrogen receptor signaling	1.0	133.0	86.0	-0.132	0.058	1000.0	-1000.0	-0.038	-1000.0
VEGFR1 specific signals	1.0	59.0	56.0	-0.03	0.043	1000.0	-1000.0	-0.035	-1000.0
S1P3 pathway	1.0	53.0	42.0	-0.088	0.037	1000.0	-1000.0	-0.035	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	1.0	194.0	120.0	-0.116	0.098	1000.0	-1000.0	-0.035	-1000.0
Visual signal transduction: Rods	1.0	73.0	52.0	-0.076	0.036	1000.0	-1000.0	-0.019	-1000.0
E-cadherin signaling in keratinocytes	1.0	84.0	43.0	-0.042	0.033	1000.0	-1000.0	-0.021	-1000.0
Class IB PI3K non-lipid kinase events	1.0	3.0	3.0	-0.014	0.014	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	1.0	106.0	78.0	-0.046	0.051	1000.0	-1000.0	-0.027	-1000.0
Regulation of nuclear SMAD2/3 signaling	0.0	94.0	136.0	-0.094	0.063	1000.0	-1000.0	-0.045	-1000.0
Coregulation of Androgen receptor activity	0.0	73.0	76.0	-0.181	0.078	1000.0	-1000.0	-0.014	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	0.0	23.0	-0.005	0.059	1000.0	-1000.0	-0.022	-1000.0
Canonical NF-kappaB pathway	0.0	14.0	39.0	-0.0	0.064	1000.0	-1000.0	-0.019	-1000.0
Signaling events mediated by HDAC Class II	0.0	30.0	75.0	-0.073	0.064	1000.0	-1000.0	-0.02	-1000.0
ErbB4 signaling events	0.0	33.0	69.0	-0.032	0.044	1000.0	-1000.0	-0.021	-1000.0
Sphingosine 1-phosphate (S1P) pathway	0.0	25.0	28.0	-0.055	0.037	1000.0	-1000.0	-0.011	-1000.0
PLK2 and PLK4 events	0.0	1.0	3.0	0.014	0.028	1000.0	-1000.0	0.003	-1000.0
Visual signal transduction: Cones	0.0	34.0	38.0	-0.025	0.042	1000.0	-1000.0	-0.0	-1000.0
Circadian rhythm pathway	0.0	2.0	22.0	-0.009	0.059	1000.0	-1000.0	-0.026	-1000.0
JNK signaling in the CD4+ TCR pathway	0.0	12.0	17.0	-0.029	0.067	1000.0	-1000.0	-0.026	-1000.0
Signaling events mediated by PTP1B	0.0	75.0	76.0	-0.107	0.049	1000.0	-1000.0	-0.043	-1000.0
Hedgehog signaling events mediated by Gli proteins	0.0	56.0	65.0	-0.098	0.065	1000.0	-1000.0	-0.04	-1000.0
Aurora A signaling	0.0	2.0	60.0	-0.0	0.07	1000.0	-1000.0	-0.016	-1000.0
Aurora C signaling	0.0	0.0	7.0	0.0	0.05	1000.0	-1000.0	-0.009	-1000.0
FOXA2 and FOXA3 transcription factor networks	0.0	38.0	46.0	-0.066	0.036	1000.0	-1000.0	-0.063	-1000.0
EPO signaling pathway	0.0	31.0	55.0	-0.021	0.08	1000.0	-1000.0	-0.03	-1000.0
PLK1 signaling events	0.0	67.0	85.0	-0.045	0.055	1000.0	-1000.0	-0.032	-1000.0
Insulin-mediated glucose transport	0.0	21.0	32.0	-0.058	0.057	1000.0	-1000.0	-0.023	-1000.0
PDGFR-alpha signaling pathway	0.0	32.0	44.0	-0.102	0.057	1000.0	-1000.0	-0.032	-1000.0
Class I PI3K signaling events mediated by Akt	0.0	16.0	68.0	-0.058	0.064	1000.0	-1000.0	-0.026	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	0.0	36.0	37.0	-0.074	0.055	1000.0	-1000.0	-0.017	-1000.0
Signaling events mediated by HDAC Class III	0.0	20.0	40.0	-0.055	0.056	1000.0	-1000.0	-0.035	-1000.0
TRAIL signaling pathway	0.0	2.0	48.0	-0.005	0.074	1000.0	-1000.0	-0.021	-1000.0
ceramide signaling pathway	0.0	10.0	49.0	-0.0	0.054	1000.0	-1000.0	-0.03	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	0.0	11.0	52.0	-0.005	0.082	1000.0	-1000.0	-0.03	-1000.0
HIF-2-alpha transcription factor network	0.0	24.0	43.0	-0.076	0.078	1000.0	-1000.0	-0.03	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	0.0	49.0	83.0	-0.073	0.056	1000.0	-1000.0	-0.021	-1000.0
Signaling events mediated by HDAC Class I	0.0	12.0	104.0	-0.054	0.064	1000.0	-1000.0	-0.035	-1000.0
FoxO family signaling	0.0	39.0	64.0	-0.058	0.041	1000.0	-1000.0	-0.03	-1000.0
Retinoic acid receptors-mediated signaling	0.0	32.0	58.0	-0.017	0.064	1000.0	-1000.0	-0.029	-1000.0
Paxillin-dependent events mediated by a4b1	0.0	24.0	36.0	-0.043	0.055	1000.0	-1000.0	-0.026	-1000.0
Atypical NF-kappaB pathway	0.0	3.0	31.0	-0.0	0.043	1000.0	-1000.0	-0.006	-1000.0
Syndecan-3-mediated signaling events	0.0	33.0	35.0	-0.059	0.077	1000.0	-1000.0	-0.015	-1000.0
IL2 signaling events mediated by PI3K	0.0	54.0	58.0	-0.095	0.051	1000.0	-1000.0	-0.028	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	0.0	30.0	45.0	-0.027	0.064	1000.0	-1000.0	-0.037	-1000.0
Regulation of p38-alpha and p38-beta	0.0	51.0	54.0	-0.087	0.067	1000.0	-1000.0	-0.041	-1000.0
Glypican 2 network	0.0	0.0	4.0	0.028	0.041	1000.0	-1000.0	0.017	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	0.0	76.0	125.0	-0.039	0.071	1000.0	-1000.0	-0.029	-1000.0
TCGA08_rtk_signaling	0.0	12.0	26.0	-0.027	0.06	1000.0	-1000.0	-0.003	-1000.0
IL6-mediated signaling events	0.0	74.0	75.0	-0.125	0.052	1000.0	-1000.0	-0.03	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	3.0	27.0	0.0	0.067	1000.0	-1000.0	-0.023	-1000.0
IL2 signaling events mediated by STAT5	0.0	18.0	22.0	-0.048	0.032	1000.0	-1000.0	-0.017	-1000.0
Class I PI3K signaling events	0.0	65.0	73.0	-0.088	0.064	1000.0	-1000.0	-0.032	-1000.0
Arf6 trafficking events	0.0	13.0	71.0	-0.033	0.061	1000.0	-1000.0	-0.03	-1000.0
Regulation of Telomerase	0.0	50.0	102.0	-0.071	0.074	1000.0	-1000.0	-0.032	-1000.0
Insulin Pathway	0.0	64.0	74.0	-0.144	0.072	1000.0	-1000.0	-0.033	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	0.0	31.0	33.0	-0.039	0.088	1000.0	-1000.0	-0.027	-1000.0
Rapid glucocorticoid signaling	0.0	11.0	20.0	-0.007	0.028	1000.0	-1000.0	-0.001	-1000.0
PDGFR-beta signaling pathway	0.0	79.0	97.0	-0.128	0.078	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by PRL	0.0	12.0	34.0	-0.052	0.045	1000.0	-1000.0	-0.023	-1000.0
FOXM1 transcription factor network	0.0	49.0	51.0	-0.134	0.066	1000.0	-1000.0	-0.073	-1000.0
p38 MAPK signaling pathway	0.0	19.0	44.0	-0.021	0.052	1000.0	-1000.0	-0.017	-1000.0
Arf1 pathway	0.0	6.0	54.0	-0.009	0.055	1000.0	-1000.0	-0.009	-1000.0
Alternative NF-kappaB pathway	0.0	0.0	13.0	0.0	0.084	1000.0	-1000.0	0.0	-1000.0
Regulation of Androgen receptor activity	0.0	69.0	70.0	-0.193	0.041	1000.0	-1000.0	-0.034	-1000.0
Ras signaling in the CD4+ TCR pathway	0.0	15.0	17.0	-0.014	0.053	1000.0	-1000.0	-0.02	-1000.0
Aurora B signaling	0.0	29.0	67.0	-0.135	0.086	1000.0	-1000.0	-0.036	-1000.0
Total	121	11025	7203	-10.7610449909	7.83715672318	131000	-131000	-3.48031730538	-131000