Clinical Features CN_CNMF METHLYATION_CNMF MRNASEQ_CNMF MRNASEQ_CHIERARCHICAL MIRSEQ_CNMF MIRSEQ_CHIERARCHICAL MIRSEQ_MATURE_CNMF MIRSEQ_MATURE_CHIERARCHICAL nCNV (%) nWild-Type Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q Fisher's exact test_P Fisher's exact test_Q amp_1p34.2 40 (22%) 144 0.3289 1 0.62911 1 0.24265 1 0.37715 1 0.74395 1 0.32516 1 0.79953 1 0.54677 1 amp_1q23.3 93 (51%) 91 0.00182 1 0.12461 1 0.091629 1 0.89584 1 0.16917 1 0.84084 1 0.01948 1 0.80909 1 amp_1q42.3 96 (52%) 88 2e-05 0.0126 0.3138 1 0.14092 1 0.26476 1 0.29904 1 0.28412 1 0.14867 1 0.26097 1 amp_2q14.2 60 (33%) 124 0.35269 1 0.30673 1 0.58001 1 0.089159 1 0.25141 1 0.20899 1 0.27073 1 0.31969 1 amp_2q31.1 60 (33%) 124 0.03199 1 0.23222 1 0.61873 1 0.16879 1 0.54342 1 0.26956 1 0.10187 1 0.65433 1 amp_3q26.2 128 (70%) 56 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 2e-05 0.0126 9.9999e-06 0.0068 3e-05 0.0188 amp_4q21.1 34 (18%) 150 0.29528 1 0.70115 1 0.04197 1 0.8275 1 0.9541 1 0.42623 1 0.92112 1 0.35803 1 amp_5p15.33 98 (53%) 86 9.9999e-06 0.0068 0.01533 1 0.065799 1 0.01131 1 0.00027 0.163 0.00386 1 0.01035 1 0.00226 1 amp_6p21.1 69 (38%) 115 0.00305 1 0.12343 1 0.31012 1 0.20266 1 0.00341 1 0.00188 1 0.0069699 1 0.00125 0.702 amp_6q23.3 42 (23%) 142 0.03688 1 0.069789 1 0.22263 1 0.30692 1 0.03272 1 0.03095 1 0.0092699 1 0.0067199 1 amp_7p11.2 126 (68%) 58 0.33141 1 0.11057 1 0.48273 1 0.02066 1 0.03754 1 0.26789 1 0.66964 1 0.12839 1 amp_7q21.2 114 (62%) 70 0.47666 1 0.15803 1 0.59503 1 0.7551 1 0.34601 1 0.60804 1 0.77111 1 0.14057 1 amp_8p23.1 52 (28%) 132 4e-05 0.0248 0.00225 1 0.04451 1 0.01533 1 0.00406 1 0.01486 1 0.00028 0.168 0.00177 0.979 amp_8p11.21 85 (46%) 99 0.49328 1 0.17391 1 0.04406 1 0.074179 1 0.3871 1 0.96596 1 0.73412 1 0.68714 1 amp_8q24.21 145 (79%) 39 0.0023 1 0.02214 1 0.01537 1 0.086439 1 0.0067199 1 0.098699 1 0.35332 1 0.14664 1 amp_9p13.3 40 (22%) 144 0.083099 1 0.1043 1 0.02966 1 0.84856 1 0.71513 1 0.13181 1 0.53469 1 0.55302 1 amp_9q34.3 64 (35%) 120 0.02589 1 0.17711 1 0.02941 1 0.95888 1 0.27099 1 0.11277 1 0.11524 1 0.67824 1 amp_11p13 52 (28%) 132 0.14194 1 0.4611 1 0.45934 1 0.51243 1 0.20387 1 0.12614 1 0.58207 1 0.25387 1 amp_11p13 50 (27%) 134 0.086379 1 0.92789 1 0.56103 1 0.87371 1 0.96301 1 0.7116 1 0.7853 1 0.4946 1 amp_11q13.3 104 (57%) 80 9.9999e-06 0.0068 0.00321 1 0.11379 1 0.00161 0.897 0.00112 0.634 0.0012 0.676 0.092089 1 0.00146 0.815 amp_12p12.1 79 (43%) 105 0.03359 1 0.12817 1 0.18273 1 0.03725 1 0.060389 1 0.084439 1 0.057849 1 0.087159 1 amp_12q15 51 (28%) 133 0.13388 1 0.5953 1 0.49631 1 0.56467 1 0.31548 1 0.59845 1 0.29581 1 0.17747 1 amp_13q22.1 65 (35%) 119 0.00173 0.958 0.0066799 1 0.22281 1 0.01084 1 0.00028 0.168 0.00223 1 0.01197 1 0.00026 0.157 amp_14q21.1 61 (33%) 123 0.00023 0.139 0.0090499 1 0.066419 1 0.0082999 1 0.00368 1 0.004 1 0.056909 1 0.01261 1 amp_15q26.1 58 (32%) 126 0.0082099 1 0.071739 1 0.02756 1 0.00366 1 0.0066199 1 0.04166 1 0.03645 1 0.01498 1 amp_17q12 75 (41%) 109 0.00448 1 0.00418 1 0.12522 1 0.26465 1 0.00205 1 0.01977 1 0.02411 1 0.00166 0.921 amp_18p11.32 69 (38%) 115 0.058999 1 0.10779 1 0.23665 1 0.44466 1 0.01697 1 0.5595 1 0.36458 1 0.51068 1 amp_18q11.2 59 (32%) 125 0.01238 1 0.01003 1 0.00111 0.629 0.00088999 0.507 0.00031 0.184 0.0088499 1 0.01477 1 0.00081999 0.471 amp_19p13.2 32 (17%) 152 0.40581 1 0.082989 1 0.82171 1 0.39573 1 0.12125 1 0.39475 1 0.32162 1 0.68503 1 amp_19q12 54 (29%) 130 0.00476 1 0.15551 1 0.0060399 1 0.04381 1 0.03889 1 0.27207 1 0.12346 1 0.051489 1 amp_xq28 69 (38%) 115 0.061029 1 0.03127 1 0.0113 1 0.03578 1 0.02915 1 0.00193 1 0.36529 1 0.00367 1 del_1p36.11 75 (41%) 109 0.01075 1 0.0090799 1 0.00066999 0.388 0.20522 1 0.00305 1 0.02338 1 0.04226 1 0.03857 1 del_1p13.2 64 (35%) 120 5.9999e-05 0.0369 0.098179 1 0.01439 1 0.54521 1 0.75549 1 0.10386 1 0.17175 1 0.90232 1 del_1q44 17 (9%) 167 0.85548 1 0.74297 1 0.8041 1 0.49626 1 0.71762 1 0.64246 1 0.80231 1 0.25547 1 del_2q22.1 59 (32%) 125 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-05 0.061 0.00050999 0.299 9.9999e-06 0.0068 2e-05 0.0126 0.00013 0.0792 9.9999e-06 0.0068 del_2q33.3 36 (20%) 148 0.29283 1 0.065899 1 0.15854 1 0.064179 1 0.01339 1 0.069529 1 0.072809 1 0.02767 1 del_3p26.2 111 (60%) 73 9.9999e-06 0.0068 3e-05 0.0188 0.00058999 0.345 0.00108 0.613 0.00019 0.115 0.00017 0.103 0.01298 1 3e-04 0.178 del_3p14.3 126 (68%) 58 9.9999e-06 0.0068 9.9999e-06 0.0068 0.00029 0.173 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 del_3p14.2 125 (68%) 59 9.9999e-06 0.0068 2e-05 0.0126 0.00112 0.634 5.9999e-05 0.0369 9.9999e-06 0.0068 9.9999e-06 0.0068 4e-05 0.0248 9.9999e-06 0.0068 del_3q11.1 33 (18%) 151 0.5917 1 0.62304 1 0.38539 1 0.6402 1 0.86316 1 0.79215 1 0.88605 1 0.62915 1 del_3q26.31 16 (9%) 168 0.00227 1 3e-05 0.0188 0.087569 1 0.00353 1 3e-04 0.178 0.00035 0.207 0.00223 1 6.9999e-05 0.0429 del_4p15.2 106 (58%) 78 0.0054799 1 0.098019 1 0.0053099 1 0.29155 1 0.04779 1 0.74678 1 0.26488 1 0.95373 1 del_4q22.1 105 (57%) 79 0.00019 0.115 0.11049 1 0.00051999 0.304 0.23859 1 0.00299 1 0.14305 1 0.051569 1 0.03621 1 del_4q34.3 99 (54%) 85 5e-04 0.293 0.0061899 1 4e-04 0.236 0.056209 1 0.00082999 0.476 0.00308 1 0.01964 1 0.00198 1 del_5q12.1 112 (61%) 72 0.00046 0.271 0.00070999 0.41 0.36089 1 1 1 0.02244 1 0.02554 1 0.43594 1 0.057509 1 del_6p25.3 74 (40%) 110 0.01612 1 0.02238 1 0.074059 1 0.52213 1 0.12294 1 0.02154 1 0.3126 1 0.091549 1 del_6q16.3 55 (30%) 129 0.14232 1 0.43581 1 0.02813 1 0.18224 1 0.12684 1 0.50804 1 0.54076 1 0.2837 1 del_6q26 50 (27%) 134 0.27173 1 0.92728 1 0.03923 1 0.17617 1 0.19592 1 0.73219 1 0.77259 1 0.33287 1 del_7q31.1 56 (30%) 128 0.2241 1 0.086779 1 0.073079 1 0.59313 1 0.40127 1 0.096119 1 0.10979 1 0.02354 1 del_7q36.3 67 (36%) 117 0.90554 1 0.70867 1 0.25493 1 0.75312 1 0.36104 1 0.14983 1 0.37725 1 0.16313 1 del_8p23.2 90 (49%) 94 8.9999e-05 0.0551 0.02799 1 0.1937 1 0.18501 1 0.0093999 1 0.10794 1 0.03679 1 0.14644 1 del_8p12 75 (41%) 109 0.00029 0.173 0.41078 1 0.75839 1 0.52588 1 0.22739 1 0.80458 1 0.5525 1 0.49366 1 del_9p23 108 (59%) 76 0.41625 1 0.12067 1 0.25056 1 0.060729 1 0.42675 1 0.72309 1 0.91497 1 0.69473 1 del_9p21.3 141 (77%) 43 9.9999e-06 0.0068 0.23561 1 0.29708 1 0.02956 1 0.03398 1 0.10355 1 0.30635 1 0.10582 1 del_10p15.3 54 (29%) 130 0.00076999 0.444 0.01974 1 0.29112 1 0.02089 1 0.0061299 1 0.01163 1 0.088919 1 0.061219 1 del_10p11.21 52 (28%) 132 9.9999e-06 0.0068 3e-05 0.0188 0.00134 0.749 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 0.00047 0.276 3e-05 0.0188 del_10q21.1 46 (25%) 138 0.00218 1 0.02032 1 0.36076 1 0.1974 1 0.01732 1 0.057589 1 0.23369 1 0.0495 1 del_10q23.31 65 (35%) 119 0.02153 1 0.03632 1 0.72927 1 0.44582 1 0.11896 1 0.28159 1 0.37074 1 0.45332 1 del_11p15.4 79 (43%) 105 0.1292 1 0.04479 1 0.62508 1 0.68567 1 0.62535 1 0.1824 1 0.80493 1 0.4584 1 del_11q25 81 (44%) 103 3e-05 0.0188 0.02799 1 0.69431 1 0.21659 1 0.057369 1 0.081949 1 0.02767 1 0.02984 1 del_12q23.1 51 (28%) 133 0.25098 1 0.01883 1 0.31958 1 0.18808 1 0.10128 1 0.1333 1 0.18087 1 0.04603 1 del_13q12.11 76 (41%) 108 0.00021 0.127 0.0134 1 0.0079099 1 0.00232 1 0.0086499 1 0.0091999 1 0.01333 1 0.01577 1 del_13q14.2 74 (40%) 110 0.00162 0.901 0.0050499 1 0.01095 1 0.011 1 0.01714 1 0.02464 1 0.02259 1 0.02533 1 del_13q21.31 69 (38%) 115 0.01297 1 0.052939 1 0.20157 1 0.083359 1 0.088069 1 0.13444 1 0.092599 1 0.13486 1 del_14q23.3 51 (28%) 133 0.00363 1 0.01527 1 0.0081199 1 0.01414 1 0.093479 1 0.01312 1 0.02802 1 0.00221 1 del_15q11.2 63 (34%) 121 0.40405 1 0.15948 1 0.094059 1 0.6273 1 0.20191 1 0.01891 1 0.64037 1 0.00374 1 del_16p13.3 65 (35%) 119 2e-05 0.0126 4e-05 0.0248 0.00028 0.168 0.00058999 0.345 3e-05 0.0188 9.9999e-06 0.0068 4e-05 0.0248 9.9999e-06 0.0068 del_16q23.1 84 (46%) 100 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 del_17p12 86 (47%) 98 8.9999e-05 0.0551 9.9999e-06 0.0068 0.0013 0.728 0.00062999 0.365 9.9999e-06 0.0068 9.9999e-06 0.0068 0.01003 1 2e-05 0.0126 del_17q25.3 41 (22%) 143 0.37203 1 0.81838 1 0.68879 1 0.90214 1 0.13024 1 0.53795 1 0.03704 1 0.70984 1 del_18p11.23 60 (33%) 124 0.31376 1 0.0057499 1 0.44292 1 0.52224 1 0.02533 1 0.13678 1 0.13934 1 0.04809 1 del_18q12.2 111 (60%) 73 0.094309 1 0.01738 1 0.12526 1 0.28505 1 0.04447 1 0.00059999 0.349 0.03553 1 0.00027 0.163 del_18q21.2 119 (65%) 65 0.15116 1 0.00082999 0.476 0.085349 1 0.171 1 0.00463 1 0.00202 1 0.01554 1 0.00060999 0.354 del_18q22.3 112 (61%) 72 0.96182 1 0.03554 1 0.069769 1 0.60732 1 0.21354 1 0.0078499 1 0.05 1 0.00070999 0.41 del_19p13.3 93 (51%) 91 4e-04 0.236 0.30168 1 0.72261 1 0.76958 1 0.03577 1 0.02264 1 0.11332 1 0.0066499 1 del_19q11 48 (26%) 136 0.21498 1 0.38691 1 0.56016 1 0.35027 1 0.35108 1 0.01454 1 0.00091999 0.523 0.02698 1 del_20p12.1 33 (18%) 151 0.034 1 0.16106 1 0.43551 1 0.053789 1 0.01658 1 0.04995 1 0.28941 1 0.04088 1 del_21q11.2 107 (58%) 77 0.12403 1 0.02756 1 0.3051 1 0.6044 1 0.04983 1 0.16996 1 0.15094 1 0.095869 1 del_21q21.1 107 (58%) 77 0.12393 1 0.0084599 1 0.096449 1 0.34203 1 0.087459 1 0.17384 1 0.072829 1 0.073749 1 del_21q22.12 108 (59%) 76 0.10256 1 0.01098 1 0.087899 1 0.43106 1 0.03238 1 0.33008 1 0.071929 1 0.2042 1 del_22q11.1 79 (43%) 105 9.9999e-06 0.0068 9.9999e-06 0.0068 0.00244 1 0.01518 1 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 9.9999e-06 0.0068 del_xp21.1 69 (38%) 115 0.00081999 0.471 0.03706 1 0.003 1 0.077749 1 0.054769 1 0.15978 1 0.11399 1 0.15047 1 del_xp11.3 74 (40%) 110 0.00085999 0.491 0.16345 1 0.00127 0.712 0.00119 0.671 0.00306 1 0.04515 1 0.03354 1 0.0179 1 del_xq11.2 42 (23%) 142 0.49457 1 0.24319 1 0.89514 1 0.48509 1 0.12628 1 0.2197 1 0.20378 1 0.71508 1 del_xq21.33 40 (22%) 144 0.16002 1 0.20592 1 0.226 1 0.1874 1 0.10265 1 0.02884 1 0.15246 1 0.18491 1