Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.366 0.318 -9999.0 0.0 -0.733 47.0 47.0 IHH -0.327 0.297 -9999.0 0.0 -0.611 63.0 63.0 SHH Np/Cholesterol/GAS1 -0.224 0.212 -9999.0 0.0 -0.384 73.0 73.0 LRPAP1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.223 0.21 0.381 73.0 -9999.0 0.0 73.0 SMO/beta Arrestin2 -0.334 0.316 -9999.0 0.0 -0.673 48.0 48.0 SMO -0.359 0.338 -9999.0 0.0 -0.719 48.0 48.0 AKT1 -0.131 0.115 -9999.0 0.0 -0.326 10.0 10.0 ARRB2 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.012 0.114 -9999.0 0.0 -0.567 5.0 5.0 ADRBK1 0.007 0.046 -9999.0 0.0 -0.506 1.0 1.0 heart looping -0.352 0.326 -9999.0 0.0 -0.695 49.0 49.0 STIL -0.355 0.262 -9999.0 0.0 -0.564 60.0 60.0 DHH N/PTCH2 -0.031 0.124 -9999.0 0.0 -0.491 8.0 8.0 DHH N/PTCH1 -0.271 0.244 -9999.0 0.0 -0.547 45.0 45.0 PIK3CA 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.022 0.143 -9999.0 0.0 -0.66 6.0 6.0 PTHLH -0.535 0.499 -9999.0 0.0 -1.131 47.0 47.0 determination of left/right symmetry -0.352 0.326 -9999.0 0.0 -0.695 49.0 49.0 PIK3R1 0.011 0.0 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.526 0.488 -9999.0 0.0 -1.109 47.0 47.0 IHH N/Hhip -0.285 0.277 -9999.0 0.0 -0.535 60.0 60.0 DHH N/Hhip -0.119 0.213 -9999.0 0.0 -0.464 32.0 32.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.352 0.326 -9999.0 0.0 -0.695 49.0 49.0 pancreas development -0.125 0.254 -9999.0 0.0 -0.593 28.0 28.0 HHAT -0.027 0.154 -9999.0 0.0 -0.66 7.0 7.0 PI3K 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.096 0.234 -9999.0 0.0 -0.597 22.0 22.0 somite specification -0.352 0.326 -9999.0 0.0 -0.695 49.0 49.0 SHH Np/Cholesterol/PTCH1 -0.375 0.267 -9999.0 0.0 -0.587 61.0 61.0 SHH Np/Cholesterol/PTCH2 -0.173 0.187 -9999.0 0.0 -0.359 60.0 60.0 SHH Np/Cholesterol/Megalin -0.2 0.201 -9999.0 0.0 -0.372 67.0 67.0 SHH -0.206 0.244 -9999.0 0.0 -0.458 59.0 59.0 catabolic process -0.288 0.256 -9999.0 0.0 -0.602 40.0 40.0 SMO/Vitamin D3 -0.406 0.308 -9999.0 0.0 -0.651 62.0 62.0 SHH Np/Cholesterol/Hhip -0.239 0.241 -9999.0 0.0 -0.415 72.0 72.0 LRP2 -0.052 0.178 -9999.0 0.0 -0.55 14.0 14.0 receptor-mediated endocytosis -0.404 0.294 -9999.0 0.0 -0.638 63.0 63.0 SHH Np/Cholesterol/BOC -0.178 0.193 -9999.0 0.0 -0.366 61.0 61.0 SHH Np/Cholesterol/CDO -0.179 0.197 -9999.0 0.0 -0.406 44.0 44.0 mesenchymal cell differentiation 0.237 0.239 0.412 72.0 -9999.0 0.0 72.0 mol:Vitamin D3 -0.376 0.268 -9999.0 0.0 -0.59 61.0 61.0 IHH N/PTCH2 -0.199 0.191 -9999.0 0.0 -0.407 50.0 50.0 CDON -0.013 0.12 -9999.0 0.0 -0.598 5.0 5.0 IHH N/PTCH1 -0.292 0.259 -9999.0 0.0 -0.56 51.0 51.0 Megalin/LRPAP1 -0.044 0.126 -9999.0 0.0 -0.394 14.0 14.0 PTCH2 -0.001 0.079 -9999.0 0.0 -0.506 3.0 3.0 SHH Np/Cholesterol -0.17 0.186 -9999.0 0.0 -0.359 59.0 59.0 PTCH1 -0.289 0.257 -9999.0 0.0 -0.605 40.0 40.0 HHIP -0.125 0.254 -9999.0 0.0 -0.594 28.0 28.0