Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.174 0.296 -9999.0 0.0 -0.579 39.0 39.0 IHH -0.069 0.206 -9999.0 0.0 -0.471 20.0 20.0 SHH Np/Cholesterol/GAS1 -0.087 0.159 -9999.0 0.0 -0.292 44.0 44.0 LRPAP1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.086 0.158 0.29 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 -0.186 0.273 -9999.0 0.0 -0.528 37.0 37.0 SMO -0.198 0.276 -9999.0 0.0 -0.543 38.0 38.0 AKT1 -0.091 0.19 -9999.0 0.0 -0.607 9.0 9.0 ARRB2 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.067 -9999.0 0.0 -0.478 2.0 2.0 ADRBK1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.197 0.272 -9999.0 0.0 -0.532 39.0 39.0 STIL -0.17 0.192 0.204 2.0 -0.357 42.0 44.0 DHH N/PTCH2 0.024 0.085 -9999.0 0.0 -0.348 6.0 6.0 DHH N/PTCH1 -0.118 0.199 -9999.0 0.0 -0.322 53.0 53.0 PIK3CA 0.021 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.003 0.108 -9999.0 0.0 -0.478 6.0 6.0 PTHLH -0.288 0.444 -9999.0 0.0 -0.878 41.0 41.0 determination of left/right symmetry -0.197 0.272 -9999.0 0.0 -0.532 39.0 39.0 PIK3R1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.284 0.439 -9999.0 0.0 -0.867 41.0 41.0 IHH N/Hhip -0.06 0.195 0.217 2.0 -0.379 29.0 31.0 DHH N/Hhip -0.015 0.159 -9999.0 0.0 -0.376 19.0 19.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.197 0.272 -9999.0 0.0 -0.532 39.0 39.0 pancreas development -0.022 0.172 -9999.0 0.0 -0.477 15.0 15.0 HHAT -0.002 0.116 -9999.0 0.0 -0.478 7.0 7.0 PI3K 0.028 0.021 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.018 0.16 -9999.0 0.0 -0.478 13.0 13.0 somite specification -0.197 0.272 -9999.0 0.0 -0.532 39.0 39.0 SHH Np/Cholesterol/PTCH1 -0.168 0.195 -9999.0 0.0 -0.32 62.0 62.0 SHH Np/Cholesterol/PTCH2 -0.059 0.138 -9999.0 0.0 -0.278 34.0 34.0 SHH Np/Cholesterol/Megalin -0.066 0.145 -9999.0 0.0 -0.278 38.0 38.0 SHH -0.096 0.164 0.238 1.0 -0.357 34.0 35.0 catabolic process -0.127 0.209 -9999.0 0.0 -0.344 56.0 56.0 SMO/Vitamin D3 -0.199 0.245 0.289 2.0 -0.477 38.0 40.0 SHH Np/Cholesterol/Hhip -0.087 0.179 -9999.0 0.0 -0.325 41.0 41.0 LRP2 0.022 0.096 -9999.0 0.0 -0.478 4.0 4.0 receptor-mediated endocytosis -0.211 0.237 -9999.0 0.0 -0.515 33.0 33.0 SHH Np/Cholesterol/BOC -0.064 0.138 -9999.0 0.0 -0.278 35.0 35.0 SHH Np/Cholesterol/CDO -0.062 0.143 -9999.0 0.0 -0.29 33.0 33.0 mesenchymal cell differentiation 0.087 0.178 0.323 41.0 -9999.0 0.0 41.0 mol:Vitamin D3 -0.161 0.206 0.258 3.0 -0.322 61.0 64.0 IHH N/PTCH2 -0.023 0.136 -9999.0 0.0 -0.316 17.0 17.0 CDON 0.019 0.065 -9999.0 0.0 -0.478 2.0 2.0 IHH N/PTCH1 -0.108 0.228 -9999.0 0.0 -0.346 56.0 56.0 Megalin/LRPAP1 0.032 0.075 -9999.0 0.0 -0.348 4.0 4.0 PTCH2 0.032 0.018 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.07 0.128 -9999.0 0.0 -0.274 34.0 34.0 PTCH1 -0.128 0.209 -9999.0 0.0 -0.345 56.0 56.0 HHIP -0.022 0.172 -9999.0 0.0 -0.478 15.0 15.0