Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization 0.005 0.055 -9999.0 0.0 -0.233 3.0 3.0 epithelial cell differentiation 0.044 0.053 -9999.0 0.0 -0.257 3.0 3.0 CYFIP2 0.031 0.025 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 EGFR 0.008 0.089 -9999.0 0.0 -0.478 4.0 4.0 EPHA2 0.025 0.045 -9999.0 0.0 -0.478 1.0 1.0 MYO6 -0.015 0.055 0.202 1.0 -0.251 3.0 4.0 CTNNB1 0.026 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.049 0.041 -9999.0 0.0 -0.296 1.0 1.0 AQP5 -0.089 0.209 -9999.0 0.0 -0.453 29.0 29.0 CTNND1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.016 0.051 -9999.0 0.0 -0.248 3.0 3.0 regulation of calcium-dependent cell-cell adhesion -0.023 0.087 0.177 5.0 -0.248 11.0 16.0 EGF -0.027 0.176 -9999.0 0.0 -0.478 16.0 16.0 NCKAP1 0.024 0.045 -9999.0 0.0 -0.478 1.0 1.0 AQP3 -0.045 0.143 0.271 1.0 -0.418 13.0 14.0 cortical microtubule organization 0.044 0.053 -9999.0 0.0 -0.257 3.0 3.0 GO:0000145 -0.016 0.048 -9999.0 0.0 -0.237 3.0 3.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.049 0.055 -9999.0 0.0 -0.26 3.0 3.0 MLLT4 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.032 0.037 -9999.0 0.0 -0.238 3.0 3.0 ARF6 0.028 0.007 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.059 0.034 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.006 0.04 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.013 0.051 0.202 1.0 -0.251 2.0 3.0 ARF6/GTP 0.063 0.038 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.015 0.078 -9999.0 0.0 -0.478 3.0 3.0 EGFR/EGFR/EGF/EGF -0.011 0.125 -9999.0 0.0 -0.281 20.0 20.0 RhoA/GDP 0.044 0.053 -9999.0 0.0 -0.249 3.0 3.0 actin cytoskeleton organization -0.018 0.052 0.183 1.0 -0.25 3.0 4.0 IGF-1R heterotetramer 0.012 0.089 -9999.0 0.0 -0.477 4.0 4.0 GIT1 0.028 0.004 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.012 0.089 -9999.0 0.0 -0.478 4.0 4.0 IGF1 -0.011 0.156 -9999.0 0.0 -0.478 12.0 12.0 DIAPH1 0.015 0.155 -9999.0 0.0 -0.569 6.0 6.0 Wnt receptor signaling pathway -0.044 0.053 0.257 3.0 -9999.0 0.0 3.0 RHOA 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.032 0.037 -9999.0 0.0 -0.24 3.0 3.0 CTNNA1 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.019 0.052 0.184 1.0 -0.255 3.0 4.0 EFNA1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 LPP -0.016 0.04 -9999.0 0.0 -0.244 2.0 2.0 Ephrin A1/EPHA2 0.038 0.052 -9999.0 0.0 -0.248 3.0 3.0 SEC6/SEC8 -0.027 0.032 -9999.0 0.0 -0.243 2.0 2.0 MGAT3 -0.023 0.089 0.178 5.0 -0.251 11.0 16.0 HGF/MET 0.022 0.089 -9999.0 0.0 -0.273 9.0 9.0 HGF 0.006 0.121 -9999.0 0.0 -0.478 7.0 7.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN 0.005 0.055 -9999.0 0.0 -0.235 3.0 3.0 actin cable formation 0.027 0.098 0.271 8.0 -9999.0 0.0 8.0 KIAA1543 -0.029 0.081 0.194 1.0 -0.294 8.0 9.0 KIFC3 -0.02 0.046 -9999.0 0.0 -0.251 3.0 3.0 NCK1 0.025 0.01 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.024 0.011 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.016 0.052 -9999.0 0.0 -0.251 3.0 3.0 NCK1/GIT1 0.036 0.016 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.044 0.053 -9999.0 0.0 -0.257 3.0 3.0 EXOC4 0.027 0.008 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.016 0.052 -9999.0 0.0 -0.251 3.0 3.0 PIP5K1C -0.016 0.052 -9999.0 0.0 -0.251 3.0 3.0 LIMA1 0.028 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.028 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.004 0.079 0.291 2.0 -9999.0 0.0 2.0 adherens junction assembly -0.028 0.107 0.256 2.0 -0.529 3.0 5.0 IGF-1R heterotetramer/IGF1 0.007 0.109 -9999.0 0.0 -0.261 16.0 16.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.041 0.011 -9999.0 0.0 -9999.0 0.0 0.0 MET 0.024 0.047 -9999.0 0.0 -0.478 1.0 1.0 PLEKHA7 -0.029 0.086 0.202 1.0 -0.308 8.0 9.0 mol:GTP 0.057 0.033 -9999.0 0.0 -9999.0 0.0 0.0 establishment of epithelial cell apical/basal polarity 0.009 0.096 0.312 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization 0.005 0.055 -9999.0 0.0 -0.233 3.0 3.0 regulation of cell-cell adhesion -0.018 0.052 0.183 1.0 -0.25 3.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton 0.005 0.055 -9999.0 0.0 -0.235 3.0 3.0