Pathway Name	Avg Num Perturbations	Total Perturbations	Num Entities	Min Mean Truth	Max Mean Truth	Min Mean Within	Max Mean Within	Min Mean Any	Max Mean Within
Signaling events mediated by the Hedgehog family	26.0	1365.0	52.0	-0.288	0.087	1000.0	-1000.0	-0.035	-1000.0
FOXA2 and FOXA3 transcription factor networks	18.0	863.0	46.0	-0.383	0.028	1000.0	-1000.0	-0.088	-1000.0
Ephrin B reverse signaling	15.0	751.0	48.0	-0.149	0.028	1000.0	-1000.0	-0.027	-1000.0
IL4-mediated signaling events	13.0	1208.0	91.0	-0.421	0.289	1000.0	-1000.0	-0.11	-1000.0
EPO signaling pathway	13.0	732.0	55.0	-0.02	0.034	1000.0	-1000.0	-0.032	-1000.0
TCGA08_retinoblastoma	13.0	111.0	8.0	-0.059	0.077	1000.0	-1000.0	-0.004	-1000.0
IL23-mediated signaling events	13.0	833.0	60.0	-0.306	0.029	1000.0	-1000.0	-0.084	-1000.0
Calcineurin-regulated NFAT-dependent transcription in lymphocytes	12.0	848.0	68.0	-0.275	0.117	1000.0	-1000.0	-0.068	-1000.0
p75(NTR)-mediated signaling	11.0	1431.0	125.0	-0.082	0.075	1000.0	-1000.0	-0.068	-1000.0
Glucocorticoid receptor regulatory network	11.0	1351.0	114.0	-0.444	0.188	1000.0	-1000.0	-0.046	-1000.0
S1P5 pathway	11.0	187.0	17.0	-0.106	0.081	1000.0	-1000.0	-0.013	-1000.0
Endothelins	11.0	1079.0	96.0	-0.125	0.044	1000.0	-1000.0	-0.048	-1000.0
TCR signaling in naïve CD8+ T cells	11.0	1107.0	93.0	-0.082	0.041	1000.0	-1000.0	-0.038	-1000.0
LPA receptor mediated events	11.0	1194.0	102.0	-0.163	0.031	1000.0	-1000.0	-0.077	-1000.0
Signaling mediated by p38-alpha and p38-beta	10.0	481.0	44.0	-0.06	0.031	1000.0	-1000.0	-0.021	-1000.0
EPHB forward signaling	10.0	910.0	85.0	-0.075	0.09	1000.0	-1000.0	-0.06	-1000.0
IGF1 pathway	10.0	600.0	57.0	-0.047	0.053	1000.0	-1000.0	-0.048	-1000.0
Osteopontin-mediated events	9.0	360.0	38.0	-0.085	0.036	1000.0	-1000.0	-0.034	-1000.0
Glypican 1 network	9.0	454.0	48.0	-0.078	0.03	1000.0	-1000.0	-0.033	-1000.0
Fc-epsilon receptor I signaling in mast cells	9.0	968.0	97.0	-0.076	0.033	1000.0	-1000.0	-0.069	-1000.0
IL12-mediated signaling events	8.0	710.0	87.0	-0.119	0.051	1000.0	-1000.0	-0.065	-1000.0
Syndecan-1-mediated signaling events	8.0	281.0	34.0	-0.062	0.029	1000.0	-1000.0	-0.035	-1000.0
BMP receptor signaling	8.0	670.0	81.0	-0.099	0.049	1000.0	-1000.0	-0.033	-1000.0
BCR signaling pathway	8.0	841.0	99.0	-0.105	0.044	1000.0	-1000.0	-0.054	-1000.0
Noncanonical Wnt signaling pathway	7.0	204.0	26.0	-0.045	0.029	1000.0	-1000.0	-0.039	-1000.0
Thromboxane A2 receptor signaling	7.0	783.0	105.0	-0.043	0.033	1000.0	-1000.0	-0.045	-1000.0
EGFR-dependent Endothelin signaling events	7.0	167.0	21.0	-0.05	0.041	1000.0	-1000.0	-0.04	-1000.0
Visual signal transduction: Rods	7.0	369.0	52.0	-0.073	0.043	1000.0	-1000.0	-0.027	-1000.0
Visual signal transduction: Cones	6.0	265.0	38.0	-0.072	0.046	1000.0	-1000.0	-0.024	-1000.0
Ephrin A  reverse signaling	6.0	46.0	7.0	-0.032	0.011	1000.0	-1000.0	-0.018	-1000.0
HIF-1-alpha transcription factor network	6.0	525.0	76.0	-0.081	0.042	1000.0	-1000.0	-0.083	-1000.0
Hedgehog signaling events mediated by Gli proteins	6.0	392.0	65.0	-0.343	0.068	1000.0	-1000.0	-0.043	-1000.0
Reelin signaling pathway	6.0	368.0	56.0	-0.03	0.07	1000.0	-1000.0	-0.035	-1000.0
Calcium signaling in the CD4+ TCR pathway	6.0	206.0	31.0	-0.09	0.028	1000.0	-1000.0	-0.044	-1000.0
Wnt signaling	6.0	44.0	7.0	-0.029	0.025	1000.0	-1000.0	-0.01	-1000.0
Neurotrophic factor-mediated Trk receptor signaling	6.0	811.0	120.0	-0.082	0.076	1000.0	-1000.0	-0.043	-1000.0
Class IB PI3K non-lipid kinase events	6.0	18.0	3.0	-0.004	0.004	1000.0	-1000.0	-0.018	-1000.0
S1P4 pathway	6.0	167.0	25.0	-0.106	0.048	1000.0	-1000.0	-0.023	-1000.0
Caspase cascade in apoptosis	5.0	420.0	74.0	-0.061	0.072	1000.0	-1000.0	-0.038	-1000.0
Arf6 signaling events	5.0	338.0	62.0	-0.035	0.059	1000.0	-1000.0	-0.032	-1000.0
amb2 Integrin signaling	5.0	438.0	82.0	-0.069	0.042	1000.0	-1000.0	-0.035	-1000.0
Signaling events regulated by Ret tyrosine kinase	5.0	446.0	82.0	-0.027	0.043	1000.0	-1000.0	-0.05	-1000.0
S1P1 pathway	5.0	213.0	36.0	-0.091	0.027	1000.0	-1000.0	-0.036	-1000.0
Retinoic acid receptors-mediated signaling	5.0	310.0	58.0	-0.048	0.052	1000.0	-1000.0	-0.04	-1000.0
Canonical Wnt signaling pathway	5.0	267.0	51.0	-0.036	0.209	1000.0	-1000.0	-0.043	-1000.0
Effects of Botulinum toxin	5.0	134.0	26.0	-0.047	0.034	1000.0	-1000.0	-0.017	-1000.0
Glypican 2 network	5.0	22.0	4.0	0.004	0.015	1000.0	-1000.0	0.018	-1000.0
Syndecan-4-mediated signaling events	5.0	367.0	67.0	-0.035	0.037	1000.0	-1000.0	-0.037	-1000.0
Plasma membrane estrogen receptor signaling	5.0	441.0	86.0	-0.106	0.045	1000.0	-1000.0	-0.05	-1000.0
FOXM1 transcription factor network	5.0	271.0	51.0	-0.074	0.073	1000.0	-1000.0	-0.104	-1000.0
ErbB2/ErbB3 signaling events	4.0	303.0	65.0	-0.035	0.041	1000.0	-1000.0	-0.046	-1000.0
Nephrin/Neph1 signaling in the kidney podocyte	4.0	151.0	34.0	-0.025	0.053	1000.0	-1000.0	-0.029	-1000.0
Sphingosine 1-phosphate (S1P) pathway	4.0	139.0	28.0	-0.106	0.038	1000.0	-1000.0	-0.026	-1000.0
Lissencephaly gene (LIS1) in neuronal migration and development	4.0	252.0	54.0	-0.037	0.04	1000.0	-1000.0	-0.043	-1000.0
Syndecan-2-mediated signaling events	4.0	343.0	69.0	-0.022	0.039	1000.0	-1000.0	-0.041	-1000.0
Signaling events mediated by PTP1B	4.0	353.0	76.0	-0.055	0.037	1000.0	-1000.0	-0.037	-1000.0
Nectin adhesion pathway	4.0	298.0	63.0	-0.03	0.052	1000.0	-1000.0	-0.039	-1000.0
Ceramide signaling pathway	4.0	325.0	76.0	-0.027	0.073	1000.0	-1000.0	-0.032	-1000.0
IL1-mediated signaling events	4.0	296.0	62.0	-0.04	0.046	1000.0	-1000.0	-0.035	-1000.0
RXR and RAR heterodimerization with other nuclear receptor	4.0	223.0	52.0	-0.034	0.059	1000.0	-1000.0	-0.035	-1000.0
HIF-2-alpha transcription factor network	4.0	176.0	43.0	-0.057	0.058	1000.0	-1000.0	-0.04	-1000.0
FAS signaling pathway (CD95)	4.0	210.0	47.0	-0.081	0.041	1000.0	-1000.0	-0.027	-1000.0
Signaling mediated by p38-gamma and p38-delta	4.0	60.0	15.0	-0.028	0.027	1000.0	-1000.0	-0.032	-1000.0
Stabilization and expansion of the E-cadherin adherens junction	4.0	298.0	74.0	-0.089	0.063	1000.0	-1000.0	-0.062	-1000.0
S1P3 pathway	4.0	186.0	42.0	-0.041	0.037	1000.0	-1000.0	-0.031	-1000.0
Angiopoietin receptor Tie2-mediated signaling	4.0	375.0	88.0	-0.05	0.037	1000.0	-1000.0	-0.078	-1000.0
PDGFR-beta signaling pathway	4.0	402.0	97.0	-0.056	0.055	1000.0	-1000.0	-0.056	-1000.0
Regulation of Androgen receptor activity	4.0	305.0	70.0	-0.288	0.045	1000.0	-1000.0	-0.046	-1000.0
Ras signaling in the CD4+ TCR pathway	4.0	70.0	17.0	-0.014	0.039	1000.0	-1000.0	-0.022	-1000.0
LPA4-mediated signaling events	3.0	44.0	12.0	-0.031	0.018	1000.0	-1000.0	-0.024	-1000.0
Coregulation of Androgen receptor activity	3.0	231.0	76.0	-0.199	0.054	1000.0	-1000.0	-0.024	-1000.0
JNK signaling in the CD4+ TCR pathway	3.0	63.0	17.0	-0.034	0.059	1000.0	-1000.0	-0.03	-1000.0
Cellular roles of Anthrax toxin	3.0	135.0	39.0	-0.026	0.03	1000.0	-1000.0	-0.022	-1000.0
Signaling events activated by Hepatocyte Growth Factor Receptor (c-Met)	3.0	313.0	85.0	-0.025	0.041	1000.0	-1000.0	-0.035	-1000.0
IFN-gamma pathway	3.0	253.0	68.0	-0.058	0.044	1000.0	-1000.0	-0.052	-1000.0
Integrins in angiogenesis	3.0	330.0	84.0	-0.064	0.062	1000.0	-1000.0	-0.044	-1000.0
HIV-1 Nef: Negative effector of Fas and TNF-alpha	3.0	135.0	45.0	-0.037	0.059	1000.0	-1000.0	-0.041	-1000.0
Nongenotropic Androgen signaling	3.0	162.0	52.0	-0.034	0.047	1000.0	-1000.0	-0.031	-1000.0
IL27-mediated signaling events	3.0	193.0	51.0	-0.143	0.029	1000.0	-1000.0	-0.053	-1000.0
Signaling events mediated by Stem cell factor receptor (c-Kit)	3.0	255.0	78.0	-0.046	0.036	1000.0	-1000.0	-0.039	-1000.0
Regulation of nuclear SMAD2/3 signaling	2.0	347.0	136.0	-0.31	0.068	1000.0	-1000.0	-0.038	-1000.0
ErbB4 signaling events	2.0	179.0	69.0	-0.053	0.045	1000.0	-1000.0	-0.038	-1000.0
Presenilin action in Notch and Wnt signaling	2.0	169.0	61.0	-0.014	0.075	1000.0	-1000.0	-0.037	-1000.0
PLK1 signaling events	2.0	229.0	85.0	-0.029	0.045	1000.0	-1000.0	-0.035	-1000.0
mTOR signaling pathway	2.0	154.0	53.0	-0.018	0.06	1000.0	-1000.0	-0.031	-1000.0
Paxillin-independent events mediated by a4b1 and a4b7	2.0	105.0	37.0	-0.021	0.061	1000.0	-1000.0	-0.031	-1000.0
ceramide signaling pathway	2.0	133.0	49.0	-0.007	0.062	1000.0	-1000.0	-0.035	-1000.0
TCGA08_p53	2.0	18.0	7.0	-0.01	0.028	1000.0	-1000.0	-0.014	-1000.0
Syndecan-3-mediated signaling events	2.0	80.0	35.0	-0.008	0.075	1000.0	-1000.0	-0.022	-1000.0
IL2 signaling events mediated by PI3K	2.0	156.0	58.0	-0.066	0.067	1000.0	-1000.0	-0.038	-1000.0
Regulation of p38-alpha and p38-beta	2.0	148.0	54.0	-0.042	0.061	1000.0	-1000.0	-0.048	-1000.0
Signaling events mediated by VEGFR1 and VEGFR2	2.0	293.0	125.0	-0.028	0.055	1000.0	-1000.0	-0.046	-1000.0
TCGA08_rtk_signaling	2.0	59.0	26.0	-0.059	0.094	1000.0	-1000.0	-0.007	-1000.0
IL6-mediated signaling events	2.0	221.0	75.0	-0.047	0.052	1000.0	-1000.0	-0.055	-1000.0
E-cadherin signaling in the nascent adherens junction	2.0	191.0	76.0	-0.026	0.057	1000.0	-1000.0	-0.054	-1000.0
Class I PI3K signaling events	2.0	218.0	73.0	-0.018	0.039	1000.0	-1000.0	-0.039	-1000.0
Regulation of Telomerase	2.0	236.0	102.0	-0.051	0.059	1000.0	-1000.0	-0.033	-1000.0
VEGFR1 specific signals	2.0	116.0	56.0	-0.024	0.048	1000.0	-1000.0	-0.034	-1000.0
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha	2.0	70.0	33.0	-0.02	0.065	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling in keratinocytes	2.0	113.0	43.0	-0.032	0.05	1000.0	-1000.0	-0.03	-1000.0
E-cadherin signaling events	2.0	12.0	5.0	0.015	0.033	1000.0	-1000.0	0.017	-1000.0
Canonical NF-kappaB pathway	1.0	48.0	39.0	-0.007	0.053	1000.0	-1000.0	-0.031	-1000.0
BARD1 signaling events	1.0	57.0	57.0	-0.05	0.074	1000.0	-1000.0	-0.039	-1000.0
Circadian rhythm pathway	1.0	33.0	22.0	-0.006	0.047	1000.0	-1000.0	-0.035	-1000.0
a4b1 and a4b7 Integrin signaling	1.0	6.0	5.0	0.021	0.036	1000.0	-1000.0	0.017	-1000.0
Aurora A signaling	1.0	71.0	60.0	-0.017	0.05	1000.0	-1000.0	-0.019	-1000.0
Arf6 downstream pathway	1.0	82.0	43.0	-0.028	0.047	1000.0	-1000.0	-0.025	-1000.0
Class I PI3K signaling events mediated by Akt	1.0	108.0	68.0	-0.033	0.051	1000.0	-1000.0	-0.039	-1000.0
Signaling events mediated by HDAC Class III	1.0	52.0	40.0	-0.054	0.054	1000.0	-1000.0	-0.033	-1000.0
TRAIL signaling pathway	1.0	59.0	48.0	-0.009	0.091	1000.0	-1000.0	-0.029	-1000.0
Role of Calcineurin-dependent NFAT signaling in lymphocytes	1.0	135.0	83.0	-0.036	0.051	1000.0	-1000.0	-0.031	-1000.0
Signaling events mediated by HDAC Class I	1.0	117.0	104.0	-0.053	0.07	1000.0	-1000.0	-0.032	-1000.0
FoxO family signaling	1.0	115.0	64.0	-0.081	0.059	1000.0	-1000.0	-0.056	-1000.0
Paxillin-dependent events mediated by a4b1	1.0	43.0	36.0	-0.049	0.054	1000.0	-1000.0	-0.034	-1000.0
IL2 signaling events mediated by STAT5	1.0	31.0	22.0	-0.016	0.037	1000.0	-1000.0	-0.041	-1000.0
Insulin Pathway	1.0	105.0	74.0	-0.026	0.063	1000.0	-1000.0	-0.04	-1000.0
Signaling events mediated by PRL	1.0	53.0	34.0	-0.029	0.042	1000.0	-1000.0	-0.035	-1000.0
p38 MAPK signaling pathway	1.0	82.0	44.0	-0.029	0.062	1000.0	-1000.0	-0.022	-1000.0
Aurora B signaling	1.0	114.0	67.0	-0.084	0.082	1000.0	-1000.0	-0.037	-1000.0
Regulation of cytoplasmic and nuclear SMAD2/3 signaling	0.0	4.0	23.0	0.0	0.046	1000.0	-1000.0	-0.035	-1000.0
Signaling events mediated by HDAC Class II	0.0	63.0	75.0	-0.031	0.072	1000.0	-1000.0	-0.027	-1000.0
PLK2 and PLK4 events	0.0	2.0	3.0	-0.016	-1000.0	1000.0	-1000.0	-0.023	-1000.0
Aurora C signaling	0.0	5.0	7.0	0.0	0.047	1000.0	-1000.0	-0.016	-1000.0
Insulin-mediated glucose transport	0.0	17.0	32.0	-0.014	0.055	1000.0	-1000.0	-0.024	-1000.0
PDGFR-alpha signaling pathway	0.0	21.0	44.0	-0.051	0.063	1000.0	-1000.0	-0.04	-1000.0
Atypical NF-kappaB pathway	0.0	18.0	31.0	-0.013	0.029	1000.0	-1000.0	-0.023	-1000.0
Sumoylation by RanBP2 regulates transcriptional repression	0.0	7.0	27.0	-0.018	0.063	1000.0	-1000.0	-0.032	-1000.0
Arf6 trafficking events	0.0	36.0	71.0	-0.047	0.051	1000.0	-1000.0	-0.028	-1000.0
Rapid glucocorticoid signaling	0.0	16.0	20.0	-0.01	0.035	1000.0	-1000.0	-0.014	-1000.0
Arf1 pathway	0.0	27.0	54.0	-0.008	0.037	1000.0	-1000.0	-0.016	-1000.0
Alternative NF-kappaB pathway	0.0	5.0	13.0	0.0	0.071	1000.0	-1000.0	-0.0	-1000.0
Total	595	39025	7203	-8.88442721984	-992.9895238	131000	-131000	-4.81098366985	-131000