rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD3E(2), CD3G(1), CD4(1), CD58(1), CD8A(1), IL3(1), IL6(1), KITLG(1) 2644975 10 10 10 1 3 1 1 3 2 0 0.152 0.00598 1.000 2 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(2), IL12B(2) 1269839 6 6 6 1 2 1 1 0 2 0 0.336 0.00623 1.000 3 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(5), AGT(1), AGTR1(1), AGTR2(1), KNG1(2), NOS3(3), REN(5) 4284311 18 18 17 2 10 2 0 2 4 0 0.0401 0.00888 1.000 4 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CCR5(1), CD28(1), CD3E(2), CD3G(1), CD4(1) 1364210 6 6 6 1 3 0 1 1 1 0 0.360 0.0138 1.000 5 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(3) 306178 3 3 3 0 2 1 0 0 0 0 0.300 0.0153 1.000 6 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 483380 3 3 3 0 0 0 1 1 1 0 0.420 0.0155 1.000 7 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(2), IFNGR1(1), IFNGR2(3), JAK1(2), JAK2(1), STAT1(2) 3472100 11 11 11 0 0 0 3 5 3 0 0.0666 0.0172 1.000 8 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(1), LDLR(3), NR0B2(1), NR1H4(3), RXRA(3) 2319597 11 11 11 2 4 2 0 4 1 0 0.239 0.0179 1.000 9 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(1), CSF2(2), HLA-DRA(1), IL3(1) 1289447 5 5 5 0 2 1 1 0 1 0 0.202 0.0278 1.000 10 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(2), GALT(1), TGDS(1), UXS1(2) 1665957 6 6 6 0 1 1 1 2 1 0 0.142 0.0303 1.000 11 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), RBL1(2), TFDP1(1) 6000334 18 17 18 2 0 2 1 8 7 0 0.216 0.0337 1.000 12 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 7 GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GPX1(1), PRKCE(1) 2559398 12 12 12 3 2 3 3 4 0 0 0.354 0.0344 1.000 13 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR2(1), GPR109B(2), GPR161(2), GPR34(2), GPR45(3), GPR65(2), GPR68(1), GPR75(1), GPR81(1) 4176509 15 14 15 3 6 2 2 2 3 0 0.115 0.0396 1.000 14 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(5), ACE2(2), AGT(1), AGTR1(1), AGTR2(1), ANPEP(2), CMA1(1), CTSG(3), ENPEP(4), LNPEP(2), MME(1), REN(5) 9005394 28 27 27 4 12 4 1 5 6 0 0.0265 0.0399 1.000 15 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), CSF2(2), EPO(1), FLT3(4), IGF1(2), IL1A(1), IL3(1), IL6(1), KITLG(1) 3536223 14 14 14 3 2 3 2 5 2 0 0.268 0.0590 1.000 16 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 11 CCNE1(1), CDKN1B(1), CUL1(3), SKP2(1), TFDP1(1), UBE2M(1) 2904181 8 8 8 1 0 1 1 4 2 0 0.347 0.0670 1.000 17 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(2), CD2(1), CD33(5), CD5(2), CD7(2), CSF2(2), IFNB1(1), IFNG(2), IL12B(2), IL3(1), ITGAX(6), TLR2(4), TLR7(4), TLR9(2) 7877452 36 34 36 8 16 3 3 10 4 0 0.0885 0.0698 1.000 18 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(2), GALT(1), TGDS(1), UXS1(2) 2109382 6 6 6 0 1 1 1 2 1 0 0.143 0.0711 1.000 19 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDK7(1), CDKN1A(1), CHEK1(3), NEK1(2), WEE1(1) 3005083 8 8 8 0 1 2 0 4 1 0 0.183 0.0977 1.000 20 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(1), CD8A(1), CSF2(2), EPO(1), IL3(1), IL6(1), IL7(1) 2604628 8 8 8 2 3 2 1 1 1 0 0.347 0.0991 1.000 21 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(2), HLA-DRA(1), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7) 5392786 25 22 25 5 13 0 3 6 3 0 0.0767 0.0999 1.000 22 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(3), GOT2(1), TAT(2), TYR(1) 1990084 7 6 6 0 4 1 2 0 0 0 0.0774 0.116 1.000 23 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 16 IFNG(2), IFNGR1(1), IFNGR2(3), IKBKB(1), JAK2(1), NFKB1(1), NFKBIA(1), TNFRSF1A(1), TNFRSF1B(1), USH1C(1), WT1(2) 6723519 15 15 15 1 2 1 4 6 2 0 0.0609 0.119 1.000 24 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 13 AKT1(1), CREB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), SP1(1) 5928318 17 16 15 3 5 6 2 1 3 0 0.133 0.119 1.000 25 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 HSD11B1(2), PPARG(1), RETN(1), RXRA(3) 2459401 7 7 7 0 3 1 0 1 2 0 0.110 0.125 1.000 26 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 8 CCNA1(1), CCNE1(1), CUL1(3), SKP2(1), TFDP1(1) 2900933 7 7 7 1 0 1 0 5 1 0 0.520 0.151 1.000 27 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(2), JAK2(1), JAK3(2), MAPK1(2), MAPK3(1), STAT3(1), TYK2(3) 5038232 12 12 12 1 6 2 1 2 1 0 0.0925 0.159 1.000 28 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR2(1), IFNB1(1), JAK1(2), STAT1(2), STAT2(1), TYK2(3) 4602823 10 10 10 1 3 1 1 3 2 0 0.157 0.160 1.000 29 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 15 CD28(1), CD3E(2), CD3G(1), CD86(2), HLA-DRA(1), PTPN11(4) 3818166 11 11 11 2 4 1 1 4 1 0 0.331 0.165 1.000 30 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 CREB1(1), PTK2B(3), SOS1(3), SRC(2) 3752639 9 9 9 1 2 1 1 3 2 0 0.249 0.168 1.000 31 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADS(3), ECHS1(1), HADHA(1) 2299164 5 5 5 1 2 2 1 0 0 0 0.358 0.175 1.000 32 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(1), CCNA2(1), CCNE1(1), CCNE2(1), CDKN1B(1), CDKN2A(2), E2F4(1), PRB1(1) 3775834 9 9 9 1 1 0 1 5 2 0 0.298 0.178 1.000 33 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(4), AOC2(1), CES1(2) 2567248 7 7 7 1 6 1 0 0 0 0 0.198 0.181 1.000 34 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CCR5(1), CD2(1), CD3E(2), CD3G(1), CD4(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), JAK2(1), STAT4(2), TYK2(3) 6293559 20 18 20 4 12 0 3 2 3 0 0.156 0.183 1.000 35 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(4), PSAT1(2) 2053439 6 5 5 1 4 2 0 0 0 0 0.225 0.200 1.000 36 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 5 AKT1(1), PLCB1(1), PLCG1(6), PRKCA(1), VAV1(4) 3841359 13 12 13 3 3 2 2 3 3 0 0.373 0.204 1.000 37 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 ELK1(2), FOS(1), MAP2K1(1), MAPK3(1), PLCG1(6), RAF1(1), SOS1(3) 6542780 15 14 15 1 3 2 3 5 2 0 0.0549 0.207 1.000 38 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(7), JAK1(2), JAK2(1), TYK2(3) 4447774 14 14 14 3 6 1 0 5 2 0 0.303 0.210 1.000 39 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA2(1), IL4R(7), JAK1(2), JAK2(1), TYK2(3) 4447774 14 14 14 3 6 1 0 5 2 0 0.303 0.210 1.000 40 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 32 AGT(1), AGTR1(1), CALM1(1), ELK1(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MEF2A(2), MEF2D(1), PAK1(1), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1) 13174734 30 28 28 4 7 9 5 5 4 0 0.0165 0.212 1.000 41 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(1), HLA-DRA(1) 1012861 3 3 3 0 3 0 0 0 0 0 0.329 0.236 1.000 42 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(1), CUL1(3), FBXW7(1), TFDP1(1) 2782560 6 6 6 1 0 1 0 3 2 0 0.521 0.237 1.000 43 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), TFDP1(1) 6268473 12 12 12 1 2 3 3 3 1 0 0.0942 0.251 1.000 44 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), IFNG(2), TGFBR1(2), TGFBR2(2), TGFBR3(1) 4512797 11 11 11 2 1 3 3 2 2 0 0.183 0.255 1.000 45 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 14 CDKN1A(1), CDKN1B(1), CDKN2A(2), MDM2(2), PRB1(1) 3180010 7 7 7 1 1 1 1 1 3 0 0.293 0.259 1.000 46 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 EGR1(3), MAP2K1(1), MAPK1(2), MAPK3(1), RAF1(1) 3525953 8 8 8 0 2 1 2 1 2 0 0.116 0.265 1.000 47 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUL(1), HAL(2) 8058632 16 15 16 1 6 3 2 3 2 0 0.0287 0.272 1.000 48 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT2(1), TAT(2) 1112386 3 3 2 0 2 1 0 0 0 0 0.315 0.281 1.000 49 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F13A1(3), F2(1), FGA(6), FGB(3), FGG(5), PLAT(2), PLG(2), SERPINB2(1), SERPINE1(2) 5678902 25 24 25 6 7 6 4 7 1 0 0.166 0.286 1.000 50 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1) 2057108 4 4 4 1 0 3 0 0 1 0 0.424 0.289 1.000 51 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 CALM1(1), CRKL(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), PAK1(1), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2), SYT1(1) 12123333 33 29 31 5 9 7 6 5 6 0 0.0211 0.323 1.000 52 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 21 CEBPB(1), ELK1(2), FOS(1), IL6(1), JAK1(2), JAK2(1), JAK3(2), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1), STAT3(1) 10215016 22 21 22 2 5 4 2 9 2 0 0.0421 0.326 1.000 53 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(2), CALM1(1), CAMK2A(1), CLCA1(2), CLCA2(1), CLCA4(1), CNGA4(3), CNGB1(2), GUCA1C(1), PDC(1), PDE1C(4), PRKG1(1), PRKG2(5), PRKX(1) 12965576 29 28 29 3 13 6 4 3 3 0 0.00627 0.327 1.000 54 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 APOBEC1(3), APOBEC2(1), APOBEC3B(1), APOBEC3F(2), APOBEC3G(1) 3098761 8 8 8 2 4 1 2 1 0 0 0.420 0.333 1.000 55 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 19 AKT1(1), CASP9(1), CHUK(1), ELK1(2), MAP2K1(1), MAPK3(1), NFKB1(1), RAF1(1), RALBP1(1), RALGDS(2) 6581568 12 12 12 1 3 2 3 2 2 0 0.0844 0.353 1.000 56 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(1), PGLYRP2(1) 770612 2 2 2 0 1 1 0 0 0 0 0.440 0.358 1.000 57 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(1), F2(1), F5(6), FGA(6), FGB(3), FGG(5), PROS1(2), SERPINC1(1) 6944066 25 25 25 6 6 6 4 6 3 0 0.158 0.368 1.000 58 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO2(1), ENO3(1), GOT2(1), PAH(2), TAT(2) 3509035 7 7 6 1 4 1 0 2 0 0 0.329 0.380 1.000 59 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(1), F2RL3(2), GNB1(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLA2G4A(3), PLCB1(1), PRKCA(1), PTGS1(1), RAF1(1), SRC(2), TBXAS1(1) 10363627 21 19 21 1 8 3 2 6 2 0 0.0116 0.386 1.000 60 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 852776 1 1 1 0 1 0 0 0 0 0 0.782 0.386 1.000 61 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CD44(3), IL1B(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF8(2), TNFSF8(1) 5711760 14 14 14 3 4 1 1 3 5 0 0.214 0.390 1.000 62 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 CREB1(1), DAXX(3), DDIT3(1), ELK1(2), MAP3K1(6), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPKAPK2(1), MAX(2), MEF2A(2), MEF2D(1), PLA2G4A(3), RIPK1(1), RPS6KA5(1), STAT1(2), TGFBR1(2) 15632928 35 32 33 4 7 12 5 8 3 0 0.00463 0.396 1.000 63 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNG(2), IFNGR1(1), JAK1(2), JAK2(1), PTPRU(1), STAT1(2) 4872602 9 9 9 1 1 0 1 4 3 0 0.308 0.397 1.000 64 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 14 ATM(4), BCL2(2), CCNE1(1), CDKN1A(1), MDM2(2), TIMP3(1) 6618334 11 11 11 1 1 1 2 2 5 0 0.334 0.406 1.000 65 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(4), CCND2(2), CDKN1B(1), CEBPB(1), EGR1(3), ESR2(3), FSHR(1), LHCGR(2), MSH5(2), NCOR1(1), NRIP1(2), PGR(5), ZP2(2) 14906594 29 28 29 3 4 8 3 10 4 0 0.0289 0.409 1.000 66 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(2), SP1(1), SP3(1), WT1(2) 2639933 6 6 6 2 1 2 0 2 1 0 0.604 0.410 1.000 67 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), IL6(1), LDLR(3) 2259343 5 5 5 2 0 1 0 4 0 0 0.776 0.420 1.000 68 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PLCG1(6), PRKCA(1), PTK2B(3) 2855115 11 10 11 3 5 1 1 2 2 0 0.350 0.426 1.000 69 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), CBS(1), CTH(1), MUT(1) 2084149 4 4 4 1 1 0 1 2 0 0 0.612 0.427 1.000 70 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(2), MEF2A(2), MEF2D(1), MYOD1(1), YWHAH(1) 3378974 8 8 8 2 1 3 1 2 1 0 0.382 0.428 1.000 71 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(2) 1367854 2 2 2 0 1 0 1 0 0 0 0.486 0.430 1.000 72 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(2), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(1) 2252596 6 6 6 2 1 2 0 1 2 0 0.499 0.441 1.000 73 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(2), ADH1C(2) 2384291 6 5 6 2 2 0 0 4 0 0 0.641 0.448 1.000 74 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ABL1(2), ATM(4), ATR(4), CCNA1(1), CCNE1(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), GSK3B(1), SKP2(1), TFDP1(1) 11647881 21 20 21 2 1 3 4 9 4 0 0.0837 0.450 1.000 75 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 11 ASAH1(1), CREB1(1), MAPK1(2), RAF1(1), SRC(2) 4189221 7 7 7 1 1 2 2 1 1 0 0.310 0.452 1.000 76 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 5 NFYB(1), SP1(1), SP3(1) 2068061 3 3 3 1 0 1 1 1 0 0 0.653 0.453 1.000 77 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(2) 1647182 3 3 3 1 2 1 0 0 0 0 0.573 0.454 1.000 78 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(4), ATR(4), CHEK1(3), YWHAH(1) 6435332 12 12 12 2 1 2 4 3 2 0 0.334 0.458 1.000 79 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(2), IDI2(1) 1823615 3 3 3 0 1 0 1 1 0 0 0.407 0.463 1.000 80 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(1), IGF1R(3), IRS1(4), MAP2K1(1), MAPK1(2), MAPK3(1), RAF1(1), SOS1(3), YWHAH(1) 6430948 17 17 17 4 2 2 5 4 4 0 0.400 0.468 1.000 81 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 ALDH6A1(1) 697988 1 1 1 0 0 0 1 0 0 0 0.685 0.479 1.000 82 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(1), CD4(1), HLA-DRA(1), IL1B(1), IL5RA(1), IL6(1) 2266494 6 6 6 2 4 0 0 1 1 0 0.591 0.490 1.000 83 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP54(2), SRPR(2) 3185647 5 5 5 0 1 1 1 1 1 0 0.228 0.507 1.000 84 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 AMT(2), ASNS(2), CA12(1), CA9(1), CPS1(5), CTH(1), GLS(1), GLUD2(3), GLUL(1), HAL(2) 9019043 19 17 19 2 8 3 2 4 2 0 0.0410 0.509 1.000 85 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(1), CALM1(1), CHRM1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PDE2A(1), PDE3A(3), PDE3B(3), PRKAR1B(1), PRKAR2B(1), PRKG1(1), PRKG2(5), RYR2(30), SLC7A1(1), SYT1(1) 17458784 68 61 68 15 30 13 9 11 5 0 0.00634 0.515 1.000 86 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(4), CHEK1(3), WEE1(1), YWHAH(1) 5850893 9 9 9 0 1 0 3 3 2 0 0.135 0.517 1.000 87 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F10(1), F13B(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), LPA(4), PLAT(2), PLG(2), SERPINB2(1), SERPINE1(2), VWF(7) 14978207 51 45 51 11 16 11 5 12 7 0 0.0254 0.528 1.000 88 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CSK(1), PRKCA(1), PTPRA(3), SRC(2) 3911924 7 7 7 0 3 3 0 1 0 0 0.0572 0.532 1.000 89 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 11 AKT1(1), CHRNG(1), MUSK(1), PTK2B(3), SRC(2), TERT(3), YWHAH(1) 5391919 12 12 12 2 5 2 1 2 2 0 0.127 0.533 1.000 90 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 20 ADCY1(3), AKT1(1), BCL2(2), CSF2RB(4), IGF1(2), IGF1R(3), IL3(1), IL3RA(2), KIT(3), KITLG(1), PRKAR1B(1), PRKAR2B(1), YWHAH(1) 7723634 25 22 24 6 10 3 2 6 4 0 0.199 0.551 1.000 91 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 20 GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), PLCG1(6), PRKCA(1), PTK2B(3), PXN(1), RAF1(1) 9109164 18 17 18 2 6 2 3 4 3 0 0.0559 0.563 1.000 92 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 AKR1A1(1), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), SIRT2(1), SIRT5(1), VNN2(1) 5046088 8 8 8 0 2 3 0 1 2 0 0.0653 0.565 1.000 93 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 BCL2(2) 1636291 2 2 2 0 0 0 0 0 2 0 1.000 0.570 1.000 94 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(1), NTRK1(1), PLCG1(6), PRKCA(1), SOS1(3) 5020178 12 11 12 3 2 2 2 4 2 0 0.327 0.574 1.000 95 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 29 ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(1), GSS(1), GSTA1(2), GSTA4(2) 7334097 12 12 12 0 4 3 1 3 1 0 0.0150 0.577 1.000 96 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(1), CPO(1), FECH(1), GATA1(1), HMBS(1) 3386319 5 5 5 1 0 1 1 3 0 0 0.496 0.582 1.000 97 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 35 ANPEP(2), G6PD(1), GGT1(1), GPX1(1), GPX4(1), GPX5(1), GSS(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), OPLAH(1) 8991922 15 15 15 0 6 4 1 3 1 0 0.00390 0.614 1.000 98 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 20 FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), MPL(3), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), STAT1(2), STAT3(1), THPO(1) 11107614 22 21 22 3 6 3 3 7 3 0 0.0701 0.616 1.000 99 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 SUCLA2(1) 893936 1 1 1 0 0 1 0 0 0 0 0.642 0.627 1.000 100 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 10 ATM(4), CHEK1(3), WEE1(1), YWHAH(1) 6376645 9 9 9 0 1 0 3 3 2 0 0.136 0.627 1.000 101 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(2), MPO(2), TPO(4), TYR(1) 4122534 9 9 9 2 6 0 1 1 1 0 0.344 0.630 1.000 102 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDH6A1(1), ALDOB(1) 1654777 2 2 2 1 0 0 1 1 0 0 0.841 0.633 1.000 103 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), MAOA(1), MAOB(2), PRPS2(2) 10394313 29 24 29 4 18 3 1 7 0 0 0.0123 0.641 1.000 104 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA2C(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), DRD1(1), DRD2(1), DRD3(1), DRD5(7), HRH2(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3) 10888266 38 36 38 9 26 5 2 5 0 0 0.00835 0.644 1.000 105 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 PLCD1(3), PRKCA(1), TGM2(1) 2132325 5 5 5 2 2 0 0 3 0 0 0.689 0.647 1.000 106 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2) 2833757 7 7 7 2 4 0 3 0 0 0 0.510 0.652 1.000 107 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 HS3ST1(2), HS3ST3A1(2), XYLT1(1), XYLT2(2) 2833757 7 7 7 2 4 0 3 0 0 0 0.510 0.652 1.000 108 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 ABL1(2), CDKN2A(2), MDM2(2), POLR1A(2), POLR1B(1) 5857893 9 9 9 0 2 1 2 1 3 0 0.0518 0.661 1.000 109 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNB1(1), JAK1(2), PTPRU(1), STAT1(2), STAT2(1), TYK2(3) 5325678 10 10 10 2 4 0 1 3 2 0 0.352 0.663 1.000 110 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BCL2(2), CASP8AP2(1), CASP9(1), CES1(2) 4767392 6 6 6 1 2 1 0 1 2 0 0.563 0.667 1.000 111 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(1), CREB1(1), MAPK1(2), MAPK3(1), MAPK7(1), MEF2A(2), MEF2D(1), NTRK1(1), PLCG1(6), RPS6KA1(1) 6492968 17 16 17 4 4 5 2 3 3 0 0.176 0.668 1.000 112 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CD28(1), CD4(1), CSF2(2), IFNG(2), IFNGR1(1), IFNGR2(3), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), IL4R(7) 8541406 30 26 30 8 14 0 4 7 5 0 0.183 0.670 1.000 113 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(2), MPO(2), TPO(4) 3579089 8 8 8 2 6 0 0 1 1 0 0.423 0.670 1.000 114 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 BCL2(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), NFKB1(1), NSMAF(2), RAF1(1), RIPK1(1), TNFRSF1A(1) 8752248 18 17 16 4 5 5 3 1 4 0 0.193 0.674 1.000 115 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 4 DCN(1) 1246324 1 1 1 1 0 0 0 0 1 0 0.897 0.674 1.000 116 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), GZMB(2) 4506411 6 6 6 1 0 1 2 0 3 0 0.355 0.678 1.000 117 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 13 AKT1(1), CDKN1B(1), ITGB1(1), MAPK1(2), MAPK3(1), SOS1(3) 6299902 9 9 9 0 1 2 3 3 0 0 0.0558 0.680 1.000 118 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(1), FECH(1), HMBS(1), PPOX(1) 3232721 4 4 4 0 0 1 1 1 1 0 0.296 0.691 1.000 119 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(1), ME1(1), PC(2), PDHA1(1), SLC25A11(1) 3930491 6 6 6 1 1 1 0 3 1 0 0.464 0.705 1.000 120 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT1(1), CHST13(1), CHSY1(2), DSE(3), UST(1), XYLT1(1), XYLT2(2) 5973536 11 11 11 1 4 2 1 2 2 0 0.0507 0.705 1.000 121 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), CD4(1), FYN(1), HLA-DRA(1), PTPRC(2), ZAP70(3) 3839630 11 11 11 4 6 0 2 2 1 0 0.591 0.706 1.000 122 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(4), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2) 8714792 20 18 20 4 6 4 1 7 2 0 0.118 0.708 1.000 123 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLUD2(3) 1919184 4 4 4 2 2 0 0 2 0 0 0.828 0.718 1.000 124 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1) 3502193 4 4 4 1 2 0 0 1 1 0 0.687 0.719 1.000 125 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA1(1), ECHS1(1), EHHADH(1), HADHA(1) 3540890 4 4 4 1 0 3 0 0 1 0 0.479 0.728 1.000 126 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(1), HADHA(1), HSD17B4(1), MECR(1) 3613794 4 4 4 0 0 2 0 1 1 0 0.300 0.730 1.000 127 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2) 3400299 6 6 6 2 4 1 0 1 0 0 0.458 0.731 1.000 128 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2) 3400299 6 6 6 2 4 1 0 1 0 0 0.458 0.731 1.000 129 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 CHRM1(1), GNB1(1), HTR2C(1), PLCB1(1) 3037326 4 4 4 1 1 1 0 1 1 0 0.668 0.734 1.000 130 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 16 AKT1(1), EIF2S2(1), EIF2S3(2), GSK3B(1), IGF1(2), IGF1R(3), INPPL1(3) 6444893 13 12 13 3 1 1 2 5 4 0 0.568 0.735 1.000 131 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT2(1), PAH(2), TAT(2), YARS2(1) 3698863 7 7 6 2 3 2 0 2 0 0 0.506 0.738 1.000 132 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(1), EIF2S2(1), NFKB1(1), NFKBIA(1) 3858077 4 4 4 1 1 0 1 1 1 0 0.553 0.753 1.000 133 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 24 ADCY1(3), AKT1(1), CAMK2A(1), CREB1(1), MAPK1(2), MAPK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RPS6KA1(1), RPS6KA5(1), SOS1(3) 10810211 17 17 17 1 8 3 2 3 1 0 0.0228 0.754 1.000 134 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1) 12290577 28 26 26 5 5 8 4 7 4 0 0.0669 0.763 1.000 135 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 13 CREB1(1), FOS(1), MAPK1(2), PRKCA(1) 3788490 5 5 5 1 1 1 1 1 1 0 0.504 0.774 1.000 136 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 15 AKT1(1), CALM1(1), GNB1(1), NFKB1(1), NOS3(3), NPPA(2), SYT1(1) 6102863 10 9 10 1 4 1 1 3 1 0 0.198 0.774 1.000 137 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), EP300(1), IKBKB(1), IL1B(1), MAP2K3(3), MAP3K7(3), NFKB1(1), NFKBIA(1), TGFBR1(2), TGFBR2(2), TLR2(4) 12618706 24 22 24 4 5 7 3 3 6 0 0.0524 0.774 1.000 138 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT7(1), B4GALT2(1), CHST1(1), CHST2(2), CHST4(1), CHST6(2), FUT8(1), ST3GAL1(1) 5313442 10 9 10 1 6 1 1 1 1 0 0.108 0.779 1.000 139 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 12 AKT1(1), CASP9(1), CHUK(1), GH1(1), NFKB1(1), NFKBIA(1), YWHAH(1) 4407358 7 7 7 2 1 2 1 2 1 0 0.477 0.781 1.000 140 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1) 4325458 6 6 6 1 2 1 0 3 0 0 0.368 0.784 1.000 141 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(2) 2600576 3 3 3 0 1 1 1 0 0 0 0.295 0.788 1.000 142 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CCR5(1), CD3E(2), CD3G(1), ETV5(1), IFNG(2), IL12B(2), IL12RB1(2), IL12RB2(2), IL18R1(2), JAK2(1), STAT4(2), TYK2(3) 7963691 21 19 21 5 11 0 4 3 3 0 0.212 0.789 1.000 143 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(1), BCL2(2), CRKL(1), FOS(1), JAK2(1), MAP2K1(1), MAP3K1(6), MAPK3(1), RAF1(1), SOS1(3), STAT1(2) 10314751 20 20 18 4 3 5 3 5 4 0 0.188 0.790 1.000 144 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDPS(2), MVD(1), MVK(1), NQO1(1) 4757480 6 6 6 0 2 0 2 1 1 0 0.195 0.793 1.000 145 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 ST3GAL1(1), ST6GALNAC4(1), ST8SIA1(1) 2397366 3 3 3 1 1 0 0 1 1 0 0.690 0.794 1.000 146 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(4), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3) 9799844 21 21 21 4 9 3 2 4 3 0 0.134 0.795 1.000 147 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(3), CD3E(2), CD3G(1), CD4(1), CREBBP(4), CSK(1), GNB1(1), HLA-DRA(1), PRKAR1B(1), PRKAR2B(1), PTPRC(2), ZAP70(3) 9799844 21 21 21 4 9 3 2 4 3 0 0.134 0.795 1.000 148 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK2(2), HK3(2), PGM1(1), TGDS(1) 4345095 6 6 6 1 4 1 0 1 0 0 0.316 0.796 1.000 149 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(2), JAK2(1), JAK3(2), PIAS1(1), PIAS3(1), PTPRU(1), SOAT1(3) 5914289 11 10 11 2 3 2 0 4 2 0 0.369 0.796 1.000 150 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(5), GLS(1) 3298444 6 5 6 2 2 0 2 2 0 0 0.668 0.798 1.000 151 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(4), DAXX(3), PAX3(3), SP100(2), TNFRSF1A(1), TNFRSF1B(1) 7062626 14 14 14 3 2 3 2 4 3 0 0.303 0.799 1.000 152 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT3(2), B4GALT2(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GCNT2(1), ST3GAL6(2), ST8SIA1(1) 6863020 16 16 16 4 7 2 1 4 2 0 0.332 0.802 1.000 153 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(4), FOS(1), IL3(1), IL3RA(2), JAK2(1), MAP2K1(1), MAPK3(1), PTPN6(1), RAF1(1), SOS1(3) 7500377 16 16 15 4 7 1 2 4 2 0 0.386 0.805 1.000 154 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 EPX(2), MPO(2), MTHFR(1), TPO(4) 4952370 9 9 9 2 6 0 1 1 1 0 0.368 0.809 1.000 155 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(1), PSMA5(1), PSMB8(2) 3700473 4 4 4 0 1 2 1 0 0 0 0.207 0.811 1.000 156 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(3), PLCE1(2), PRKAR1B(1), PRKAR2B(1), RAP2B(2) 6286626 9 9 9 0 4 2 1 1 1 0 0.0370 0.816 1.000 157 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(2), CYR61(1), IFNG(2), IFRD1(1), IL1A(1), IL1R1(2), WDR1(2) 4626691 11 11 11 7 0 3 1 2 5 0 0.955 0.817 1.000 158 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 10 GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), SRC(2) 4289992 12 11 12 4 2 4 2 4 0 0 0.508 0.817 1.000 159 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(5), ACACB(7), MCAT(1), OXSM(1) 6800035 14 14 14 3 7 2 1 3 1 0 0.230 0.818 1.000 160 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 19 ADCY1(3), AKT1(1), ASAH1(1), GNB1(1), ITGAV(1), ITGB3(1), MAPK1(2), MAPK3(1), PLCB1(1), PRKCA(1), SRC(2) 9126774 15 15 15 2 6 5 1 2 1 0 0.0716 0.818 1.000 161 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(2), EIF2S2(1), EIF2S3(2), GSK3B(1) 4910905 7 7 7 2 0 1 2 2 2 0 0.630 0.824 1.000 162 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(2), EPO(1), FOS(1), JAK2(1), MAP2K1(1), MAPK3(1), PLCG1(6), PTPN6(1), RAF1(1), SOS1(3) 9160787 18 17 18 4 5 2 3 6 2 0 0.270 0.825 1.000 163 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 FOS(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), NFKBIA(1), PLCB1(1), PRKCA(1), RAF1(1) 6579926 10 10 10 2 3 1 2 2 2 0 0.365 0.825 1.000 164 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 IL6(1), JAK1(2), JAK2(1), JAK3(2), PIAS3(1), PTPRU(1), SRC(2), STAT3(1) 6542749 11 11 11 2 3 3 0 4 1 0 0.288 0.830 1.000 165 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), CPT1A(1), CPT2(1), EHHADH(1), HADHA(1) 7143160 11 10 11 2 4 2 2 1 2 0 0.194 0.832 1.000 166 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BIRC3(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 3601428 4 4 4 1 1 0 1 2 0 0 0.589 0.838 1.000 167 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 GAD1(1), GGT1(1) 2452281 2 2 2 0 0 2 0 0 0 0 0.374 0.839 1.000 168 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 17 ADCY1(3), F2(1), F2RL3(2), GNB1(1), MAP3K7(3), PLCB1(1), PPP1R12B(1), PRKCA(1), PTK2B(3), ROCK1(2) 9435598 18 17 18 3 8 3 1 2 4 0 0.113 0.840 1.000 169 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(2), PARK2(1) 2719804 3 3 3 0 2 0 0 1 0 0 0.360 0.840 1.000 170 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(1), CD3E(2), CD3G(1), GZMB(2), ICAM1(1), ITGB2(4) 3707758 11 11 11 6 3 0 2 2 4 0 0.780 0.841 1.000 171 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(3), GNB1(1) 2811420 4 4 4 0 2 1 0 1 0 0 0.269 0.843 1.000 172 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRM1(1) 1380439 1 1 1 0 0 1 0 0 0 0 0.565 0.845 1.000 173 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(1), NCOA1(1), NCOA2(3), PPARG(1), RXRA(3) 7845719 13 13 13 3 3 2 1 2 5 0 0.374 0.849 1.000 174 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 GLS(1), PRODH(1) 2362656 2 2 2 1 1 0 0 1 0 0 0.804 0.849 1.000 175 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT3(2), FUT5(3), FUT6(1) 2174439 7 7 7 3 4 0 0 3 0 0 0.653 0.850 1.000 176 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), GZMB(2), SCAP(1), SREBF1(1), SREBF2(1) 7811487 9 9 9 1 2 1 2 3 1 0 0.203 0.854 1.000 177 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACPT(2), ENPP1(1), TYR(1) 4115504 4 4 4 0 2 0 1 1 0 0 0.301 0.856 1.000 178 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP6(2), ACPT(2), ENPP1(1), LHPP(1), MTMR1(2), TYR(1) 6378333 9 9 9 2 5 1 2 1 0 0 0.353 0.856 1.000 179 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 CKB(1), CKM(1), CKMT1B(2), CPS1(5), GAMT(1), GATM(2), NAGS(1), OTC(2) 7483232 15 15 15 4 4 2 4 5 0 0 0.420 0.858 1.000 180 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GPX1(1), GSS(1), NFKB1(1), XDH(3) 4251755 6 6 6 2 2 1 0 3 0 0 0.616 0.861 1.000 181 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(1), ESR1(1), MAPK1(2), MAPK3(1), SRC(2) 6262097 11 11 11 3 1 4 2 2 2 0 0.382 0.862 1.000 182 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ECHS1(1), EHHADH(1), HADHA(1) 5171704 9 9 9 3 4 3 0 1 1 0 0.359 0.863 1.000 183 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), TAX1BP3(1), UBE2E3(1), UBE2M(1), UBE3A(1) 4472034 5 5 5 1 2 1 1 0 1 0 0.325 0.867 1.000 184 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), DDC(3), EPX(2), GOT2(1), MAOA(1), MAOB(2), MPO(2), TAT(2), TPO(4) 9372075 26 24 25 5 17 2 1 5 1 0 0.0525 0.872 1.000 185 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ACACA(5), ACACB(7), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), LDHAL6A(1), LDHAL6B(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2) 16832110 30 28 30 4 11 7 2 8 2 0 0.0245 0.872 1.000 186 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(1), NDUFA4(1), NDUFS2(1) 2972368 3 3 3 1 0 1 0 1 1 0 0.723 0.873 1.000 187 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(1), HLA-DRA(1) 1688651 3 3 3 2 3 0 0 0 0 0 0.800 0.879 1.000 188 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(3), CYP11B2(2), HSD11B1(2) 2925973 9 9 9 4 5 3 0 0 1 0 0.545 0.882 1.000 189 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 ELK1(2), GNB1(1), IGF1R(3), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PTPRR(3), RAF1(1), RPS6KA1(1), RPS6KA5(1), SOS1(3), SRC(2), STAT3(1) 12068907 23 23 23 4 6 5 3 7 2 0 0.125 0.882 1.000 190 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GGT1(1) 1794349 1 1 1 0 0 1 0 0 0 0 0.585 0.884 1.000 191 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1A3(1), ALDH3A1(2), MIOX(1) 3637048 4 4 4 1 3 0 0 1 0 0 0.499 0.886 1.000 192 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CTH(1), GOT2(1) 2892853 2 2 2 0 0 1 0 1 0 0 0.539 0.894 1.000 193 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 BCL2(2), CASP9(1), DAXX(3), IL1A(1), MAPKAPK2(1), MAPKAPK3(1) 4824263 9 8 9 3 1 3 1 2 2 0 0.603 0.894 1.000 194 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RANBP2(1), RANGAP1(2) 3565182 3 3 3 0 1 0 0 1 1 0 0.404 0.896 1.000 195 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(1), CAPN1(2), CAPNS1(1), CSNK1D(1), GSK3B(1) 3999313 6 6 6 2 1 2 1 2 0 0 0.515 0.902 1.000 196 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 GLI2(3), GLI3(1), GSK3B(1), PRKAR1B(1), PRKAR2B(1), SHH(2), SMO(1), SUFU(1) 7131126 11 10 11 2 4 1 1 3 2 0 0.306 0.903 1.000 197 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), MAPK3(1), OPRK1(1), POLR2A(2), PRKAR1B(1), PRKAR2B(1) 5478131 8 8 8 2 3 1 0 2 2 0 0.506 0.904 1.000 198 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2) 5654565 9 8 9 3 4 0 0 5 0 0 0.564 0.904 1.000 199 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK2(2), HK3(2), PGM1(1), TGDS(1) 4971588 6 6 6 1 4 1 0 1 0 0 0.301 0.908 1.000 200 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), PPP1R1B(1) 1624132 2 2 2 2 2 0 0 0 0 0 0.834 0.910 1.000 201 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(1), ALPP(2), ALPPL2(4) 2803539 7 6 7 3 5 1 1 0 0 0 0.468 0.911 1.000 202 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(3), FSHR(1) 4070908 4 4 4 0 2 2 0 0 0 0 0.225 0.911 1.000 203 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(4), LCT(3), NEU1(1), NEU2(3), NEU4(2) 7075584 13 11 13 3 4 4 1 3 1 0 0.222 0.911 1.000 204 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASS(1), KARS(2) 2000648 3 3 3 2 2 0 0 1 0 0 0.892 0.911 1.000 205 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 EPX(2), MPO(2), TPO(4) 5043095 8 8 8 2 6 0 0 1 1 0 0.404 0.912 1.000 206 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), IL1B(1), MST1(2), MST1R(2) 2795973 6 6 6 3 1 0 1 2 2 0 0.871 0.913 1.000 207 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(5), MAP2(1), PRKAR2B(1), PRKCE(1) 7707285 8 7 8 0 0 1 2 2 3 0 0.211 0.915 1.000 208 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 11 ARPC2(1), PAK1(1) 3126001 2 2 2 1 0 0 0 0 2 0 1.000 0.915 1.000 209 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(3), CFTR(2), PRKAR1B(1), PRKAR2B(1) 5583723 7 7 7 0 4 1 0 2 0 0 0.104 0.916 1.000 210 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(1), ALOX5(1), CYP1A2(2), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP3A4(2), CYP3A43(1), CYP3A5(5), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1) 10138955 23 22 23 5 9 3 2 8 1 0 0.182 0.918 1.000 211 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABP1(4), ALDH1A3(1), ALDH3A1(2), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HIBCH(1), MLYCD(1) 11483297 19 18 19 3 8 5 0 5 1 0 0.0525 0.922 1.000 212 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 CDKN1A(1), EPO(1), JAK2(1), NFKB1(1), NFKBIA(1) 5401381 5 5 5 0 2 1 0 2 0 0 0.210 0.922 1.000 213 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 18 ELK1(2), FOS(1), IGF1(2), IGF1R(3), IRS1(4), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1) 8935599 23 21 23 6 3 3 4 9 4 0 0.420 0.923 1.000 214 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), PDE6A(2), PDE6B(2), SLC6A13(2) 15333172 22 22 22 2 13 6 1 0 2 0 0.00249 0.923 1.000 215 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(1), IARS(3), IL4R(7), INPP5D(3), JAK1(2), JAK2(1), JAK3(2), NR0B2(1), SOS1(3), SRC(2), STAT6(1), TYK2(3) 14826788 29 29 29 5 12 5 1 9 2 0 0.0712 0.924 1.000 216 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1) 7727374 12 11 10 3 2 5 1 3 1 0 0.302 0.925 1.000 217 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(5), CPT1A(1), LEPR(1), PRKAG2(1) 6135736 8 8 8 2 4 0 0 2 2 0 0.596 0.925 1.000 218 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(3), GNB1(1), MAPK1(2), MAPK3(1), PRKAR1B(1), PRKAR2B(1), RPS6KA1(1), SRC(2) 8765536 12 12 12 1 5 3 1 3 0 0 0.0641 0.925 1.000 219 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 F13B(1), HSD17B3(1), HSD17B4(1) 3431425 3 3 3 2 0 2 0 0 1 0 0.812 0.930 1.000 220 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT2(1), FUT8(1), ST3GAL1(1) 3343331 3 3 3 0 1 0 0 1 1 0 0.421 0.930 1.000 221 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 32 CRKL(1), DOCK1(2), ELK1(2), FOS(1), HGF(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAP4K1(2), MAPK1(2), MAPK3(1), MET(3), PAK1(1), PTK2B(3), PTPN11(4), PXN(1), RAF1(1), SOS1(3), SRC(2), STAT3(1) 16898702 35 31 35 5 11 6 4 11 3 0 0.0220 0.931 1.000 222 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACYP1(1), ECHS1(1), EHHADH(1), HADHA(1) 3315134 4 4 4 2 0 3 0 0 1 0 0.720 0.933 1.000 223 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(1), ATM(4), BCL2(2), CASP9(1), PRKCA(1), PXN(1), STAT1(2) 11325625 12 12 12 1 1 1 2 3 5 0 0.244 0.935 1.000 224 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 18 B2M(1), ITGB1(1), KLRC1(1), KLRC3(4), KLRD1(1), MAP2K1(1), MAPK3(1), PAK1(1), PTK2B(3), PTPN6(1), VAV1(4) 6312165 19 16 19 6 5 1 3 5 5 0 0.610 0.935 1.000 225 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDPS(2), MVD(1), MVK(1) 5653473 5 5 5 0 2 0 2 1 0 0 0.190 0.940 1.000 226 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHA4(1), EPHB1(2), FYN(1), ITGA1(2), ITGB1(1), L1CAM(5), LYN(2), SELP(2) 6695594 16 16 16 5 7 2 5 2 0 0 0.384 0.945 1.000 227 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(1), CREB1(1), DUSP10(1), ELK1(2), IL1R1(2), MAP2K3(3), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAPK1(2), MAPK13(1), MAPKAPK2(1), NFKB1(1), NR2C2(1), SRF(1) 14238525 24 22 24 4 6 8 5 2 3 0 0.0558 0.946 1.000 228 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG12(2), ATG5(1), IFNA10(2), IFNA21(1), IFNG(2), INS(1), ULK1(1), ULK2(2) 8971557 12 11 12 3 1 2 2 3 4 0 0.385 0.948 1.000 229 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GGT1(1) 2393367 1 1 1 0 0 1 0 0 0 0 0.600 0.949 1.000 230 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 GZMB(2) 4033315 2 2 2 1 0 0 1 0 1 0 0.804 0.950 1.000 231 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP4(1), BMP5(4), BMP6(1), BTRC(1), CSNK1D(1), CSNK1G1(1), CSNK1G3(1), DHH(1), FBXW11(1), GLI1(4), GLI2(3), GLI3(1), GSK3B(1), HHIP(1), IHH(1), LRP2(15), PRKX(1), PTCH2(2), RAB23(1), SHH(2), SMO(1), SUFU(1), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1) 25648508 57 52 57 9 26 8 6 9 8 0 0.00331 0.950 1.000 232 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), STAT6(1) 6346422 17 17 17 5 6 2 1 4 4 0 0.459 0.951 1.000 233 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(4), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5E(2) 6174722 10 10 9 4 4 2 2 2 0 0 0.526 0.952 1.000 234 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(1), ANKRD6(2), APC(1), AXIN1(3), AXIN2(1), DACT1(1), DKK1(1), DKK2(3), DVL1(1), FSTL1(1), GSK3B(1), LRP1(9), MVP(3), NKD1(1), PSEN1(1), PTPRA(3), WIF1(1) 17279100 34 31 34 5 13 3 5 8 5 0 0.0255 0.953 1.000 235 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR1(2) 2720959 3 3 3 2 2 0 1 0 0 0 0.871 0.955 1.000 236 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CCL2(1), CCR5(1), FOS(1), PLCG1(6), PRKCA(1), PTK2B(3), SYT1(1) 5838350 15 14 15 5 5 1 2 4 3 0 0.451 0.956 1.000 237 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CDK7(1), SHH(2) 3706422 3 2 3 0 2 1 0 0 0 0 0.306 0.957 1.000 238 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(3), GNB1(1), PRKAG2(1), PRKAR1B(1), PRKAR2B(1) 6542846 7 7 7 0 3 1 0 3 0 0 0.130 0.959 1.000 239 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(2), CD3G(1), CD8A(1), ICAM1(1), ITGB2(4), PTPRC(2) 4552140 13 13 13 9 6 0 1 3 3 0 0.903 0.962 1.000 240 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 CHAT(2), PCYT1A(2), PDHA1(1), PDHA2(3), SLC18A3(1) 2979972 9 9 9 5 5 1 1 0 2 0 0.681 0.962 1.000 241 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(1), FDPS(2), IDI2(1), MVD(1), MVK(1), NQO1(1) 8262742 8 8 8 1 2 1 2 2 1 0 0.301 0.962 1.000 242 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNB1(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1) 4100404 4 4 4 1 2 0 0 2 0 0 0.658 0.963 1.000 243 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), GCNT2(1), ST8SIA1(1) 2618535 3 3 3 2 2 0 0 0 1 0 0.880 0.964 1.000 244 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 8 ACO1(1), SUCLA2(1) 3405262 2 2 2 0 0 1 0 1 0 0 0.529 0.965 1.000 245 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(1), GH1(1), IGF1(2), IGF1R(3) 4051391 7 7 7 3 0 2 1 3 1 0 0.707 0.966 1.000 246 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(1), CD3E(2), CD3G(1), CD4(1), ICAM1(1), ITGB2(4), PTPRC(2) 4780462 13 13 13 9 6 0 1 3 3 0 0.908 0.967 1.000 247 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), ITGA1(2), ITGB1(1), ITGB3(1), PXN(1), SPTAN1(3), SRC(2) 12127234 16 15 16 1 6 1 1 7 1 0 0.0569 0.968 1.000 248 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 LDLR(3), SCAP(1), SREBF1(1), SREBF2(1) 5130085 6 6 6 2 1 2 0 3 0 0 0.591 0.968 1.000 249 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 4 EGF(3), NRG1(2) 3235423 5 5 5 4 0 0 0 4 1 0 0.964 0.969 1.000 250 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 BIRC2(1), BIRC3(1), CASP1(2), CASP10(1), CASP9(1), GZMB(2), LMNB2(1) 8227520 9 9 9 2 1 1 3 2 2 0 0.390 0.969 1.000 251 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1) 5409794 6 6 6 2 1 0 2 3 0 0 0.630 0.970 1.000 252 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2) 14090013 20 19 20 3 3 4 7 6 0 0 0.0819 0.970 1.000 253 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CARM1(1), CREB1(1), CREBBP(4), EP300(1), PRKAR1B(1), PRKAR2B(1), RXRA(3) 8789558 12 12 12 3 3 2 1 2 4 0 0.430 0.970 1.000 254 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(3), CALM1(1), CREB1(1), ELK1(2), FOS(1), GNB1(1), MAP2K1(1), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), RAF1(1), RPS6KA3(1), SYT1(1) 14899891 28 27 28 5 9 4 3 7 5 0 0.0766 0.971 1.000 255 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(3), PDHA1(1), PDHA2(3) 4257939 7 7 7 3 2 3 0 1 1 0 0.687 0.971 1.000 256 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 GFPT1(1), GNPDA1(1), HK2(2), HK3(2), RENBP(1) 7186008 7 7 7 1 4 0 1 1 1 0 0.373 0.972 1.000 257 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 OXCT2(1) 3066460 1 1 1 1 1 0 0 0 0 0 0.906 0.973 1.000 258 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNB1(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL1RN(2), IL6(1), IRAK1(2), IRAK2(1), IRAK3(3), MAP2K3(3), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1) 12629530 31 29 29 8 7 10 3 6 5 0 0.119 0.973 1.000 259 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 19 ACO1(1), DLD(2), IDH3A(1), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2) 8368888 12 12 12 3 2 4 0 6 0 0 0.380 0.973 1.000 260 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(1), LCMT1(1), LCMT2(1), METTL6(1), PCYT1A(2), PCYT1B(1), PRMT8(1) 6025372 8 8 8 2 4 0 0 2 2 0 0.502 0.974 1.000 261 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6399853 11 11 11 4 4 2 1 4 0 0 0.582 0.974 1.000 262 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6399853 11 11 11 4 4 2 1 4 0 0 0.582 0.974 1.000 263 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6399853 11 11 11 4 4 2 1 4 0 0 0.582 0.974 1.000 264 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 5 ABCB11(2), ABCB4(6), ABCC1(1), ABCC3(1) 4973700 10 10 10 7 2 3 1 1 3 0 0.813 0.974 1.000 265 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP6(2), ACPT(2), ALPI(1), ALPP(2), ALPPL2(4), CYP3A4(2), CYP3A43(1), CYP3A5(5), PON1(2) 7656106 21 20 21 7 12 2 3 4 0 0 0.320 0.974 1.000 266 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(1), GNB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLCB1(1), PPP1R12B(1), PRKCA(1), RAF1(1), ROCK2(1) 9647124 11 11 11 2 3 3 2 1 2 0 0.306 0.974 1.000 267 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 CHST13(1), SULT2B1(1), SUOX(1) 3915718 3 3 3 0 1 1 0 1 0 0 0.348 0.975 1.000 268 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), DARS(1), EPRS(2), HARS(2), IARS(3), KARS(2), MARS(2), QARS(2), RARS(1), TARS(1), WARS(1) 13586452 18 18 18 3 3 3 3 7 2 0 0.273 0.976 1.000 269 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), EP300(1), IKBKB(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 9537925 12 11 12 3 2 3 1 3 3 0 0.349 0.976 1.000 270 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CBS(1), CTH(1), GGT1(1), MARS(2), MAT1A(2), SCLY(1) 5256923 8 7 8 3 2 2 0 3 1 0 0.686 0.977 1.000 271 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(1), HAO1(2), HAO2(1), HYI(1), MTHFD1(1) 5668393 6 6 6 2 1 0 2 3 0 0 0.629 0.978 1.000 272 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2) 3968502 12 12 12 5 5 3 0 2 2 0 0.680 0.978 1.000 273 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), CYP11A1(3), CYP11B1(1), CYP11B2(2), CYP21A2(2), HSD11B1(2) 3968502 12 12 12 5 5 3 0 2 2 0 0.680 0.978 1.000 274 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(1), C6(1), C8A(2), C9(2) 5378702 12 12 12 6 3 1 1 4 3 0 0.839 0.979 1.000 275 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CAMKK1(1), CREB1(1), SYT1(1) 4945513 7 7 7 4 2 0 1 1 3 0 0.883 0.979 1.000 276 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(1), CBR1(2), CYP4F2(3), CYP4F3(2), EPX(2), GGT1(1), MPO(2), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1), TPO(4) 11878641 27 26 27 6 16 2 0 6 3 0 0.112 0.980 1.000 277 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 SUOX(1) 2575664 1 1 1 0 0 0 0 1 0 0 0.837 0.980 1.000 278 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 PRKCA(1), PSEN1(1) 3810158 2 2 2 0 1 0 0 1 0 0 0.567 0.981 1.000 279 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(2), CKM(1), NCL(1) 3791724 4 4 4 2 2 0 1 0 1 0 0.795 0.981 1.000 280 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 DPYD(2), DPYS(1), ENPP1(1) 5926460 4 4 4 1 0 0 0 4 0 0 0.741 0.982 1.000 281 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(1), ALOX5(1), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 6426199 11 10 11 3 5 2 0 2 2 0 0.289 0.982 1.000 282 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), STX5(1), STX6(1), STX7(1), TSNARE1(2), USE1(1), VAMP5(1), VAMP7(3) 7154300 11 11 11 3 3 0 3 4 1 0 0.509 0.984 1.000 283 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(2) 5783099 6 6 6 2 1 1 1 1 2 0 0.701 0.984 1.000 284 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C8B(3), C9(2) 8921312 20 20 20 6 7 4 1 5 3 0 0.374 0.985 1.000 285 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1) 6811928 11 11 11 4 4 2 1 4 0 0 0.585 0.985 1.000 286 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(1), DDX20(1), E2F4(1), ETS1(2), FOS(1), HDAC2(3), NCOR2(2), RBL1(2), SIN3A(2) 11176943 15 14 15 2 3 3 1 5 3 0 0.206 0.986 1.000 287 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(1), AXIN1(3), BMP2(1), BMP4(1), BMP5(4), BMPR2(1), CHRD(1), DVL1(1), FZD1(1), GATA4(2), GSK3B(1), MAP3K7(3), NPPA(2), RFC1(1), TGFBR1(2), TGFBR2(2), TGFBR3(1), WNT1(1) 15539058 29 25 29 5 6 6 5 8 4 0 0.0662 0.986 1.000 288 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), MEF2A(2), MEF2D(1), PPARA(1), PPP3CB(1), SYT1(1), YWHAH(1) 8655592 11 11 11 3 2 2 2 3 2 0 0.412 0.987 1.000 289 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), F10(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), PROS1(2), SERPINC1(1), SERPING1(1) 19031781 57 51 57 15 12 15 8 14 8 0 0.0881 0.987 1.000 290 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BCL2(2), BIRC2(1), BIRC3(1), CASP9(1) 5782774 5 5 5 2 0 0 1 2 2 0 0.928 0.987 1.000 291 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CHUK(1), EGR2(2), EGR3(1), MAP3K1(6), NFATC2(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), SYT1(1), VIPR2(1) 11882184 26 23 24 7 6 6 4 6 4 0 0.170 0.987 1.000 292 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), MAPK8IP3(3), PAPPA(2), RPS6KA1(1), RPS6KA3(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1) 13697360 32 29 30 8 9 8 6 7 2 0 0.120 0.988 1.000 293 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 10 ACLY(1), ACO1(1), SUCLA2(1) 5266553 3 3 3 0 0 1 0 1 1 0 0.428 0.988 1.000 294 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(2), CYP2A13(1), XDH(3) 3376477 6 6 6 5 2 2 0 1 1 0 0.884 0.988 1.000 295 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 10 CBL(1), CSF1R(1), EGF(3), MET(3), PRKCA(1), SRC(2) 6162790 11 8 11 4 2 1 1 6 1 0 0.770 0.989 1.000 296 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ARPC2(1) 3446428 1 1 1 1 0 0 0 0 1 0 1.000 0.989 1.000 297 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1) 9956570 8 8 8 1 2 3 2 0 1 0 0.186 0.989 1.000 298 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(1), GAD1(1), HDC(3), TPH1(2) 2586206 7 7 7 4 4 1 0 2 0 0 0.744 0.990 1.000 299 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IKBKB(1), IL1A(1), IL1R1(2), IRAK1(2), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 10417684 21 20 19 6 4 9 2 4 2 0 0.256 0.990 1.000 300 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 NCOA1(1), NCOA2(3), NCOR2(2), POLR2A(2), RXRA(3), TBP(2) 10677473 13 13 13 3 2 2 0 3 6 0 0.443 0.991 1.000 301 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(1), CREBBP(4), EP300(1), MAP2K1(1), MAP3K7(3), MAPK3(1), TGFBR1(2), TGFBR2(2) 10877230 15 15 15 4 1 5 4 1 4 0 0.359 0.991 1.000 302 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(1), ESR2(3), PDE1A(2), PLCB1(1), PLCB2(3), TRH(1) 4715398 11 11 11 6 3 3 0 3 2 0 0.838 0.991 1.000 303 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 CLOCK(2), CRY1(1), PER1(1) 3644136 4 4 4 3 1 1 0 1 1 0 0.942 0.992 1.000 304 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 CASP10(1), DAXX(3), FAF1(1), LMNB2(1), MAP3K1(6), MAP3K7(3), PAK1(1), PRKDC(3), PTPN13(1), SPTAN1(3) 16943189 23 22 21 4 3 9 4 3 4 0 0.0641 0.992 1.000 305 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(4), ATR(4), BRCA1(4), BRCA2(4), CHEK1(3), FANCD2(2), MRE11A(1), RAD50(1) 18363009 23 23 23 4 5 4 6 6 2 0 0.148 0.993 1.000 306 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 14 AKT1(1), MAPK1(2), MAPK3(1), PTK2B(3), SOS1(3) 7394467 10 10 10 3 3 2 2 2 1 0 0.482 0.993 1.000 307 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ABL1(2), ATM(4), BRCA1(4), CDKN1A(1), CHEK1(3), MDM2(2), MRE11A(1), NFKB1(1), NFKBIA(1), RAD50(1), RBBP8(1) 12322813 21 21 21 5 7 2 3 5 4 0 0.415 0.993 1.000 308 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CDKN1A(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), SP1(1), SP3(1), SYT1(1) 8895994 17 16 17 5 4 4 2 4 3 0 0.308 0.993 1.000 309 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(3), CASP1(2), CASP10(1), CASP9(1), GZMB(2) 5462603 9 9 8 5 1 1 1 4 2 0 0.861 0.994 1.000 310 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 HMOX1(1), IL1A(1), IL6(1), JAK1(2), STAT1(2), STAT3(1) 5187339 8 8 8 4 1 2 0 3 2 0 0.743 0.994 1.000 311 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 IARS(3), PDHA1(1), PDHA2(3), VARS(1), VARS2(2) 7923155 10 10 10 3 2 3 2 2 1 0 0.461 0.994 1.000 312 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNB1(1), IFNG(2), IL12B(2), IL16(1), IL1A(1), IL3(1), IL6(1) 4196550 9 9 9 5 2 2 1 3 1 0 0.749 0.994 1.000 313 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ACAA1(1), ACADS(3), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), DBT(1), DLD(2), ECHS1(1), EHHADH(1), HADHA(1), HIBCH(1), HSD17B4(1), MCCC1(1), MUT(1), OXCT2(1), PCCA(2), PCCB(1) 18300781 27 26 26 5 12 7 4 2 2 0 0.0402 0.994 1.000 314 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 MMP9(2), RECK(1), TIMP3(1) 3193896 4 4 4 3 2 0 0 2 0 0 0.877 0.995 1.000 315 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), PSEN1(1) 4033736 2 2 2 1 0 0 0 1 1 0 0.931 0.995 1.000 316 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(4), CALM1(1), EPS15(2), PICALM(1), PPP3CB(1), SYNJ2(3), SYT1(1) 9267389 13 13 13 4 7 0 2 2 2 0 0.366 0.995 1.000 317 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(2), ACTN3(1), CAPN1(2), CAPNS1(1), CRKL(1), CSK(1), FYN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), SOS1(3), SRC(2), ZYX(2) 20099087 28 23 28 3 7 5 6 7 3 0 0.0174 0.995 1.000 318 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(4), CCNA1(1), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CREB3L1(1), CREB3L3(3), CREB3L4(1), E2F4(1), E2F6(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), NACA(1), ORC3L(1), ORC5L(1), POLA2(1), POLE2(1), PRIM1(1), RBL1(2), RPA2(1), TFDP1(1), TNXB(3), WEE1(1) 31730863 55 48 55 9 7 8 8 19 13 0 0.0319 0.995 1.000 319 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), CYP11A1(3), HPGD(1), HSD11B1(2), PLA2G4A(3), PTGER4(1), PTGFR(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 8779969 17 17 17 5 7 2 0 4 4 0 0.344 0.995 1.000 320 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT2(1), GALNT6(1), GALNT7(1), GALNT9(2), GCNT1(2), ST3GAL1(1), WBSCR17(6) 6108802 15 15 15 7 6 3 1 2 3 0 0.770 0.996 1.000 321 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(4), AKR1B10(1), ALAS1(1), AMT(2), AOC2(1), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PHGDH(1), PIPOX(1), PISD(1), PSAT1(2), PSPH(1), SARDH(1), SARS2(1), TARS(1), TARS2(1) 18288677 36 34 36 7 14 7 1 12 2 0 0.0613 0.996 1.000 322 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 16 CTH(1), GOT2(1), LDHAL6A(1), LDHAL6B(1) 5055934 4 4 4 2 0 1 0 3 0 0 0.878 0.996 1.000 323 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 AKT1(1), ATM(4), CDKN1A(1), CSNK1D(1), MDM2(2), NQO1(1) 7396547 10 10 10 4 1 3 2 0 4 0 0.755 0.996 1.000 324 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(4), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), DDC(3), EPX(2), ESCO1(1), GOT2(1), MAOA(1), MAOB(2), MPO(2), MYST4(1), TAT(2), TPO(4) 14553304 28 25 27 5 17 4 1 5 1 0 0.0357 0.996 1.000 325 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(3), CASP1(2), GAPDH(1), INS(1), INSR(2), ITCH(1), MAGI1(2), MAGI2(2), RERE(4), WWP2(1) 10203599 19 17 19 5 3 6 2 5 3 0 0.374 0.996 1.000 326 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN3(1), CSK(1), CTNNA1(2), CTNNA2(2), PXN(1), SRC(2) 8156079 11 10 11 3 2 3 1 4 1 0 0.495 0.996 1.000 327 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C9(2) 7526996 17 17 17 6 6 2 1 5 3 0 0.576 0.996 1.000 328 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), AGTR2(1), CALM1(1), CAMK2A(1), F2(1), FYN(1), GNB1(1), JAK2(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PLCG1(6), PRKCA(1), PTK2B(3), RAF1(1), SOS1(3), STAT1(2), STAT3(1), SYT1(1) 17757280 32 29 32 7 7 3 6 10 6 0 0.118 0.996 1.000 329 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(1), CSF2(2), HLA-DRA(1), IFNB1(1), IFNG(2), IL12B(2), IL1A(1), IL3(1), IL6(1), IL7(1) 5671762 13 13 13 6 4 3 2 2 2 0 0.622 0.996 1.000 330 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ARPC2(1), NCKAP1(1), NTRK1(1), WASF3(1) 6482448 4 4 4 5 0 0 1 0 3 0 0.994 0.997 1.000 331 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 14 AKT1(1), CDKN1A(1), ELK1(2), MAP2K1(1), NTRK1(1), SOS1(3) 6042203 9 9 9 4 1 3 1 2 2 0 0.632 0.997 1.000 332 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 29 AKT1(1), ANGPTL2(1), DAG1(2), DGKA(1), GCA(1), ITGA9(2), ITPR1(5), ITPR2(3), ITPR3(5), MAP2K1(1), MAPK1(2), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(3), PDE3B(3), RIPK3(1), RPS4X(1), VASP(1) 18141564 36 34 36 9 12 12 3 3 6 0 0.0496 0.997 1.000 333 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 32 AKT1(1), ASAH1(1), DAG1(2), DRD2(1), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PIK3CB(4), PITX2(3), PLCB1(1), PLCB2(3), PLCB4(1), RAF1(1), SOS1(3), SRC(2), STAT3(1) 23258843 45 40 45 8 14 14 6 7 4 0 0.00716 0.998 1.000 334 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 LCT(3), PGM1(1), PYGL(1), PYGM(1), TREH(1) 5704517 7 7 7 3 3 2 1 1 0 0 0.588 0.998 1.000 335 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 EGF(3), ELK1(2), FOS(1), JAK1(2), MAP2K1(1), MAP3K1(6), MAPK3(1), PLCG1(6), PRKCA(1), RAF1(1), SOS1(3), SRF(1), STAT1(2), STAT3(1) 13202389 31 29 29 9 5 8 4 10 4 0 0.349 0.998 1.000 336 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 IMPDH1(2), POLD1(1), PRPS2(2) 5369314 5 5 5 2 4 0 0 1 0 0 0.680 0.998 1.000 337 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(1), PSMA5(1), PSMC3(1) 6771467 3 3 3 1 0 1 1 0 1 0 0.747 0.998 1.000 338 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 9 EGF(3), MAP2K1(1), MAP3K1(6), NCOR2(2), RXRA(3), THRA(1) 6262997 16 16 14 7 3 5 1 4 3 0 0.790 0.998 1.000 339 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 19 ELK1(2), FOS(1), INS(1), INSR(2), IRS1(4), MAP2K1(1), MAPK3(1), PTPN11(4), RAF1(1), SOS1(3), SRF(1) 9249301 21 20 21 7 4 4 3 7 3 0 0.545 0.998 1.000 340 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(1), PSMA5(1), PSMC3(1), UBE3A(1) 5484648 4 4 4 2 0 1 2 0 1 0 0.810 0.998 1.000 341 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(2), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), PDHA1(1), PDHA2(3) 10954598 20 20 20 7 8 6 1 2 3 0 0.337 0.998 1.000 342 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(2), AGT(1), AGTR1(1), AGTR2(1), CMA1(1), COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), REN(5) 10871720 30 27 29 10 9 9 4 4 4 0 0.325 0.998 1.000 343 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), CHAT(2), DBH(1), DDC(3), GAD1(1), HDC(3), MAOA(1), PAH(2), SLC18A3(1), TPH1(2) 6149632 17 16 17 7 10 1 2 4 0 0 0.493 0.999 1.000 344 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1) 10214287 6 6 6 1 2 1 1 1 1 0 0.458 0.999 1.000 345 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 12 AKT1(1), BCL2(2), IGF1R(3), POLR2A(2), PRKCA(1), TEP1(4), TERT(3), TNKS(1), XRCC5(1) 9777465 18 18 18 6 4 4 2 3 5 0 0.543 0.999 1.000 346 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(1), AXIN1(3), BTRC(1), DLL1(1), DVL1(1), FZD1(1), GSK3B(1), PSEN1(1), WNT1(1) 9219499 11 10 11 4 1 1 1 5 3 0 0.767 0.999 1.000 347 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR2(4), HLA-DRA(1), ICAM1(1), ITGB2(4), PTPRC(2) 6474045 12 11 12 9 6 1 0 3 2 0 0.935 0.999 1.000 348 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(4), ADC(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(1), ASS1(1), CPS1(5), GATM(2), MAOA(1), MAOB(2), NAGS(1), OTC(2) 12590336 26 26 26 8 10 3 4 8 1 0 0.406 0.999 1.000 349 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT5(1), ST6GAL1(1) 8442453 9 9 9 3 4 1 0 2 2 0 0.471 0.999 1.000 350 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(2), CREBBP(4), EP300(1), FYN(1), IL7(1), IL7R(2), JAK1(2), JAK3(2), PTK2B(3) 10349725 18 18 18 7 4 4 2 2 6 0 0.656 0.999 1.000 351 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(4), ACY3(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), CARM1(1), CNDP1(2), DDC(3), HAL(2), HARS(2), HDC(3), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), PRMT8(1), PRPS2(2), UROC1(1) 16900789 33 29 33 6 20 2 1 9 1 0 0.0322 0.999 1.000 352 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 MAP2K3(3), NFATC2(2), PRKAR1B(1), PRKAR2B(1) 5203117 7 6 7 5 4 0 0 1 2 0 0.743 0.999 1.000 353 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 DIAPH2(3), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), NACA(1), ORC3L(1), ORC5L(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), PRIM1(1), RFC1(1), RFC4(1), RPA2(1), RPA4(2), UBA52(1), UBC(2) 21685413 31 31 31 5 7 6 4 11 3 0 0.0600 0.999 1.000 354 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 18 AKT1(1), EIF4A1(1), EIF4B(1), EIF4G1(1), EIF4G3(1), TSC2(3) 9843004 8 8 8 2 2 2 0 4 0 0 0.519 0.999 1.000 355 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(1), AKT1(1), BTK(1), CDKN2A(2), GSK3B(1), IARS(3), INPP5D(3), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TEC(1), YWHAE(2), YWHAH(1) 14024992 24 23 24 6 5 8 2 6 3 0 0.190 0.999 1.000 356 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(1), BCL2(2), GSK3B(1), IL4R(7), IRS1(4), JAK1(2), JAK3(2), MAP4K1(2), MAPK1(2), MAPK3(1), RAF1(1), SOCS1(1), SOS1(3), STAT6(1) 14017071 30 30 30 9 9 3 4 8 6 0 0.456 0.999 1.000 357 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 EIF2B1(1), EIF2S2(1), EIF2S3(2), ELAVL1(1), FLT1(5), FLT4(2), KDR(8), NOS3(3), PLCG1(6), PRKCA(1), PXN(1) 12943369 31 28 31 9 11 6 3 7 4 0 0.214 0.999 1.000 358 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(4), AOC2(1), CES1(2), ESCO1(1), MYST4(1), PLA1A(1), PPME1(1) 10789490 12 12 12 4 7 3 0 2 0 0 0.433 0.999 1.000 359 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ESR1(1), MTA1(1), MTA3(1), TUBA8(1) 4716140 4 4 4 5 2 0 0 1 1 0 0.949 0.999 1.000 360 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1S(3), C2(2), C3(6), C5(1), C6(1), C8A(2), C9(2), MASP2(1), MBL2(1) 9148335 19 19 19 7 6 3 1 6 3 0 0.566 0.999 1.000 361 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1C4(2), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(2), CYP27A1(1), CYP7A1(1), SRD5A1(1), SRD5A2(1) 9900631 21 20 21 8 8 5 1 7 0 0 0.497 0.999 1.000 362 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CARM1(1), CBS(1), CTH(1), GGT1(1), LCMT1(1), LCMT2(1), MARS(2), MAT1A(2), METTL6(1), PRMT8(1), SCLY(1) 10615379 13 12 13 4 5 2 0 4 2 0 0.528 1.000 1.000 363 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(1), AGT(1), AGTR2(1), EGF(3), FOS(1), NFKB1(1), PLCG1(6), PRKCA(1) 7576965 15 13 15 6 4 1 2 7 1 0 0.713 1.000 1.000 364 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 19 AKT1(1), EIF4A1(1), EIF4G1(1), EIF4G3(1), IRS1(4), MAPK1(2), MAPK3(1), PRKCA(1) 10009178 12 11 12 4 3 2 2 3 2 0 0.626 1.000 1.000 365 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(4), CARM1(1), CREBBP(4), EP300(1), ESR1(1), GRIP1(7), HDAC2(3), HDAC4(1), HDAC6(1), NCOR2(2), NRIP1(2), POLR2A(2), TBP(2) 19805182 31 29 31 7 8 10 2 5 6 0 0.0964 1.000 1.000 366 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR2(1), MTNR1B(1), PTAFR(1), PTGER4(1), PTGFR(1) 4810181 5 5 5 9 3 0 0 1 1 0 0.996 1.000 1.000 367 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), AOX1(4), DBH(1), DCT(1), DDC(3), GOT2(1), MAOA(1), MAOB(2), TAT(2), TPO(4), TYR(1) 13500254 35 32 33 10 22 3 2 8 0 0 0.114 1.000 1.000 368 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), NFKB1(1) 6209163 2 2 2 2 1 0 0 0 1 0 0.888 1.000 1.000 369 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 28 CREB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), NFKB1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SOS1(3) 11978013 13 13 13 4 4 2 2 3 2 0 0.546 1.000 1.000 370 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPL13(1), RPL10L(2), RPL11(2), RPL13A(1), RPL22L1(1), RPL36A(2), RPL3L(1), RPL7(1), RPS12(1), RPS21(1), RPS5(1) 9721608 15 14 15 6 4 1 2 2 6 0 0.874 1.000 1.000 371 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 20 ARHGAP5(3), FYN(1), GSN(1), ITGA1(2), ITGB1(1), MAP2K1(1), MAPK1(2), MAPK3(1), MYLK(2), PXN(1), RAF1(1), ROCK1(2), SRC(2) 14295959 20 18 19 5 4 2 3 7 4 0 0.396 1.000 1.000 372 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 FUCA1(4), HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), MAN2B1(5), MAN2B2(2), NEU1(1), NEU2(3), NEU4(2), SPAM1(4) 14776567 30 28 29 9 11 6 1 10 2 0 0.248 1.000 1.000 373 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 24 AKT1(1), APC(1), AXIN1(3), DVL1(1), FZD1(1), GSK3B(1), IRAK1(2), LBP(3), LY96(2), NFKB1(1), WNT1(1) 11543219 17 16 17 5 5 4 3 3 2 0 0.409 1.000 1.000 374 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(1), CETP(2), CYP7A1(1), DGAT1(2), LCAT(1), LDLR(3), LRP1(9), SCARB1(1), SOAT1(3) 11638665 23 22 23 8 5 3 2 6 7 0 0.573 1.000 1.000 375 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 AMT(2), MTHFD1(1), MTHFR(1) 7601920 4 4 4 2 1 0 2 0 1 0 0.802 1.000 1.000 376 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(3), GNB1(1), MYLK(2), PLCB1(1), PPP1R12B(1), PRKCA(1), ROCK1(2) 8792612 11 11 10 6 2 1 0 5 3 0 0.910 1.000 1.000 377 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(3), EPHB2(3), F2(1), F2RL3(2), MAPK1(2), MAPK7(1), PLD1(1), RAF1(1), RASAL1(1), SRC(2), TEC(1), VAV1(4) 11713207 23 22 23 7 8 5 3 5 2 0 0.323 1.000 1.000 378 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ASNS(2), CAD(3), CRAT(1), DARS(1), GAD1(1), GOT2(1), PC(2) 11072827 12 12 12 4 0 3 3 4 2 0 0.611 1.000 1.000 379 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(1), CNDP1(2), DPYD(2), DPYS(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), MLYCD(1) 12340731 21 20 21 7 10 5 0 5 1 0 0.299 1.000 1.000 380 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 CRADD(1), LMNB2(1), MADD(1), MAP3K1(6), MAP3K7(3), PAK1(1), PRKDC(3), RIPK1(1), SPTAN1(3), TNFRSF1A(1) 16001281 21 20 19 5 4 7 3 4 3 0 0.168 1.000 1.000 381 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA1(1), ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), AKR1B10(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), CEL(2), CYP27A1(1), CYP7A1(1), SOAT1(3), SRD5A1(1), SRD5A2(1) 13545307 24 22 24 8 7 6 1 9 1 0 0.452 1.000 1.000 382 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 DPYD(2), DPYS(1), ENPP1(1) 7355325 4 4 4 2 0 0 0 4 0 0 0.875 1.000 1.000 383 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACOT11(1), ACYP1(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), ITGB1BP3(1), MYST4(1), YOD1(1) 11027242 9 9 9 3 3 5 0 0 1 0 0.433 1.000 1.000 384 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 AMT(2), MTHFD1(1), MTHFR(1) 8061615 4 4 4 2 1 0 2 0 1 0 0.803 1.000 1.000 385 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1A3(1), ALDH3A1(2), CYP2C19(1), ECHS1(1), EHHADH(1), ESCO1(1), HADHA(1), MYST4(1), YOD1(1) 13137748 11 10 11 3 5 4 0 1 1 0 0.292 1.000 1.000 386 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 CHUK(1), IFNG(2), IKBKB(1), MAP3K1(6), MAP3K5(1), NFKB1(1), NFKBIA(1), TNFRSF9(1), TNFSF9(3) 8277615 17 15 14 8 5 5 3 2 2 0 0.622 1.000 1.000 387 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BCL2(2), BIRC2(1), BIRC3(1), CASP10(1), CASP9(1), CHUK(1), NFKB1(1), NFKBIA(1), RIPK1(1), SPTAN1(3), TNFRSF25(1), TNFSF10(2) 14276736 16 15 16 4 4 0 2 6 4 0 0.491 1.000 1.000 388 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(1), ABCG2(2), BCHE(2), CES1(2), CYP3A4(2), CYP3A5(5), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2) 9660684 21 21 21 9 11 1 3 4 2 0 0.487 1.000 1.000 389 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(1), ASAH1(1), CREB1(1), DAG1(2), EPHB2(3), FOS(1), MAPK1(2), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3) 12151575 17 17 17 5 5 3 6 1 2 0 0.373 1.000 1.000 390 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(2), FOS(1), IKBKB(1), IRAK1(2), LY96(2), MAP2K3(3), MAP3K1(6), MAP3K7(3), NFKB1(1), NFKBIA(1), PPARA(1), TLR10(2), TLR2(4), TLR3(1), TLR6(5), TLR7(4), TLR9(2) 15573783 42 40 40 12 14 11 4 8 5 0 0.166 1.000 1.000 391 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(2), JAK1(2), JAK2(1), JAK3(2), STAT1(2), STAT3(1), TYK2(3) 7886078 13 13 13 5 6 1 0 4 2 0 0.594 1.000 1.000 392 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 17 RPE(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1) 7009089 9 9 9 7 4 2 0 2 1 0 0.913 1.000 1.000 393 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 40 BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), GZMB(2), MAP3K1(6), MCL1(1), MDM2(2), NFKB1(1), NFKBIA(1), PARP1(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFSF10(2), TRAF1(1) 15608847 25 25 23 8 5 5 4 6 5 0 0.413 1.000 1.000 394 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(2), ADH1A(2), ADH1B(2), ADH1C(2), ESCO1(1), MYST4(1) 10617885 10 9 10 4 2 3 0 5 0 0 0.685 1.000 1.000 395 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACAA1(1), ELOVL2(1), HADHA(1) 6166667 3 3 3 2 1 2 0 0 0 0 0.672 1.000 1.000 396 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ACACA(5), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), ECHS1(1), EHHADH(1), HADHA(1), MLYCD(1), MUT(1), PCCA(2), PCCB(1), SUCLA2(1), SUCLG1(2) 14028566 23 22 23 7 9 6 2 4 2 0 0.351 1.000 1.000 397 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(1), BTK(1), GSK3B(1), LYN(2), PFKL(1), PLCG1(6), PRKCE(1), VAV2(2) 10701992 15 14 15 5 3 5 3 3 1 0 0.368 1.000 1.000 398 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 25 CP(4), EPRS(2), FECH(1), HCCS(1), HMBS(1), HMOX1(1), PPOX(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1) 11165643 19 18 19 6 6 2 2 7 2 0 0.449 1.000 1.000 399 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 CSNK1D(1), DRD1(1), DRD2(1), GRM1(3), PLCB1(1), PPP1R1B(1), PRKAR1B(1), PRKAR2B(1) 6817871 10 10 10 5 6 1 0 2 1 0 0.762 1.000 1.000 400 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 CREB1(1), EP300(1), EPO(1), NOS3(3), P4HB(1) 7292594 7 7 7 5 4 1 0 1 1 0 0.910 1.000 1.000 401 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ADC(2), ALDH5A1(1), CAD(3), CPS1(5), EPRS(2), GAD1(1), GFPT1(1), GLS(1), GLUD2(3), GLUL(1), GOT2(1), GSS(1), NADSYN1(1), QARS(2) 16786049 25 24 25 6 5 4 7 8 1 0 0.246 1.000 1.000 402 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(1), ANAPC4(2), ANAPC7(1), BTRC(1), CDC23(2), CDC27(1), CUL1(3), CUL2(1), FBXW11(1), FBXW7(1), FZR1(1), ITCH(1), SKP2(1), SMURF1(2), UBE2E3(1), WWP2(1) 17210939 21 21 21 5 4 2 4 6 5 0 0.385 1.000 1.000 403 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), POLI(2), POLL(1), POLQ(3), PRIM1(1), PRIM2(1), REV1(2), REV3L(1) 17420081 16 16 16 4 5 2 1 7 1 0 0.488 1.000 1.000 404 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 40 CALM1(1), CD3E(2), CD3G(1), ELK1(2), FOS(1), FYN(1), MAP2K1(1), MAP3K1(6), MAPK3(1), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4), ZAP70(3) 18742835 42 38 40 11 12 7 8 9 6 0 0.123 1.000 1.000 405 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1) 6402718 5 5 5 3 3 0 0 1 1 0 0.844 1.000 1.000 406 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLD1(1), POLL(1), POLQ(3) 7105957 5 5 5 3 2 0 0 3 0 0 0.918 1.000 1.000 407 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B4GALNT1(1), LCT(3), SLC33A1(1), ST3GAL1(1), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1) 6983981 9 9 9 8 3 2 0 3 1 0 0.963 1.000 1.000 408 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), ATP7A(3), COX10(2), COX7C(1), NDUFA10(1), NDUFA4(1), NDUFS2(1), PPA2(1), UQCRC1(1) 16248082 22 22 22 6 6 5 2 8 1 0 0.285 1.000 1.000 409 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 CHUK(1), CRADD(1), IKBKB(1), MAP2K3(3), MAP3K1(6), MAP4K2(1), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1A(1) 10334529 17 15 15 9 5 5 1 3 3 0 0.788 1.000 1.000 410 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(4), ALAS1(1), AMT(2), AOC2(1), CBS(1), CTH(1), DAO(3), DLD(2), DMGDH(2), GAMT(1), GATM(2), GCAT(1), GLDC(1), MAOA(1), MAOB(2), PISD(1), PLCB2(3), PLCG1(6), PLCG2(3), PSPH(1), SARDH(1), TARS(1) 17967745 41 35 41 10 15 7 2 14 3 0 0.112 1.000 1.000 411 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 30 AKT1(1), APC(1), ASAH1(1), CCL13(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PITX2(3), RAF1(1), SRC(2) 19504563 30 29 30 8 9 10 5 3 3 0 0.0867 1.000 1.000 412 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), IKBKB(1), MAP3K1(6), NFKB1(1), NFKBIA(1), RIPK1(1), TNFRSF1B(1), TRAF1(1) 9558723 15 14 13 6 4 5 1 4 1 0 0.529 1.000 1.000 413 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 CLOCK(2), CRY1(1), CSNK1D(1), PER1(1), PER2(3), PER3(1) 7293507 9 9 9 5 4 3 0 1 1 0 0.815 1.000 1.000 414 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(4), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AMD1(2), AOC2(1), CKB(1), CKM(1), CKMT1B(2), CPS1(5), DAO(3), GAMT(1), GATM(2), GOT2(1), MAOA(1), MAOB(2), NOS1(5), NOS3(3), OTC(2), P4HB(1), RARS(1) 18935361 44 41 44 12 23 7 5 9 0 0 0.0942 1.000 1.000 415 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(1), CALM1(1), ELK1(2), FCER1A(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK1(2), MAPK3(1), NFATC2(2), NFATC4(2), PLA2G4A(3), PLCG1(6), PPP3CB(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4) 16699361 42 36 40 12 8 12 8 9 5 0 0.146 1.000 1.000 416 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(2), CHUK(1), DAXX(3), EGF(3), ETS1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK13(1), MAPK3(1), NFKB1(1), NFKBIA(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), RAF1(1), RIPK1(1), SP1(1), TNFRSF1A(1), TNFRSF1B(1) 19792665 44 41 41 12 12 9 7 9 7 0 0.198 1.000 1.000 417 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 21 ATM(4), ATR(4), BRCA1(4), CDKN1A(1), CHEK1(3), EP300(1), MDM2(2), PRKDC(3), RPS6KA1(1), WEE1(1), YWHAH(1) 17679323 25 25 25 7 6 7 4 4 4 0 0.311 1.000 1.000 418 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), CEL(2), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1) 20626882 40 38 40 11 16 8 0 12 4 0 0.143 1.000 1.000 419 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 CBS(1), CTH(1), MARS(2), MAT1A(2) 7421086 6 6 6 6 2 1 0 2 1 0 0.980 1.000 1.000 420 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM1(1), CAPNS1(1), EP300(1), HDAC2(3), MEF2D(1), NFATC2(2), PPP3CB(1), PRKCA(1), SYT1(1) 10342087 17 17 17 7 5 3 3 3 3 0 0.578 1.000 1.000 421 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(1), BCL2(2), CBL(1), CRKL(1), FOS(1), IRS1(4), JAK1(2), JAK3(2), MAPK1(2), MAPK3(1), PTPN6(1), RAF1(1), SOCS1(1), SOS1(3) 13824634 23 23 23 8 6 2 4 6 5 0 0.708 1.000 1.000 422 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BIRC2(1), BIRC3(1), MAP3K7(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1) 11604415 17 16 17 6 2 4 4 5 2 0 0.574 1.000 1.000 423 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(1), AXIN1(3), BTRC(1), CREBBP(4), CSNK1D(1), DVL1(1), FZD1(1), GSK3B(1), MAP3K7(3), WIF1(1), WNT1(1) 12553660 18 17 18 7 1 4 3 5 5 0 0.712 1.000 1.000 424 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT2(1), EXTL1(1), HS3ST1(2), HS3ST3A1(2), NDST3(1), NDST4(6) 8844888 13 12 13 5 5 1 5 2 0 0 0.559 1.000 1.000 425 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 26 ACLY(1), ACO1(1), CLYBL(4), DLD(2), IDH3A(1), OGDHL(3), PC(2), PCK1(3), SUCLA2(1), SUCLG1(2) 12278447 20 20 20 7 3 4 1 11 1 0 0.607 1.000 1.000 426 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 AKT1(1), DAG1(2), ITPR1(5), ITPR2(3), ITPR3(5), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PITX2(3), PLD1(1) 19182003 31 27 31 8 8 11 3 5 4 0 0.0983 1.000 1.000 427 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 23 CAPN1(2), CAPNS1(1), EGF(3), ITGA1(2), ITGB1(1), MAPK1(2), MAPK3(1), MYLK(2), PRKAR1B(1), PRKAR2B(1), PXN(1) 12837107 17 17 17 6 5 1 2 8 1 0 0.617 1.000 1.000 428 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(1), AXIN1(3), CREBBP(4), DVL1(1), EP300(1), FZD1(1), GSK3B(1), PITX2(3), TRRAP(6), WNT1(1) 14119985 22 21 22 9 3 5 3 5 6 0 0.702 1.000 1.000 429 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(1), CSK(1), DAG1(2), DTYMK(1), EPHB2(3), FBXW7(1), GRAP2(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PAK1(1), PAK4(2), PAK7(1), PLCG1(6), PTPRC(2), RAF1(1), RASGRP1(1), RASGRP2(1), RASGRP4(1), SOS1(3), VAV1(4), ZAP70(3) 23896489 46 43 46 10 13 8 7 11 7 0 0.0886 1.000 1.000 430 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), DLG4(3), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), NOS1(5), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), SYT1(1) 10898738 30 28 30 11 21 1 2 5 1 0 0.330 1.000 1.000 431 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 67 A2M(2), BDKRB1(1), C1QC(1), C1S(3), C2(2), C3(6), C4BPB(1), C5(1), C5AR1(3), C6(1), C8A(2), C8B(3), C9(2), CD46(2), CD55(1), CD59(1), CFB(1), CFH(2), CFI(1), CR2(4), F10(1), F13A1(3), F13B(1), F2(1), F5(6), F8(6), F9(4), FGA(6), FGB(3), FGG(5), KLKB1(2), KNG1(2), MASP2(1), MBL2(1), PLAT(2), PLG(2), PROS1(2), SERPINA1(2), SERPINA5(1), SERPINC1(1), SERPINE1(2), SERPING1(1), VWF(7) 38603215 102 82 102 28 32 21 11 24 14 0 0.0350 1.000 1.000 432 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(2), ADH1C(2), AGPAT1(2), AGPAT2(1), AGPAT6(1), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), CEL(2), DGAT1(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), GK2(1), LCT(3), LIPF(1), LIPG(1), PNLIP(1) 25093263 41 40 41 10 16 7 0 13 5 0 0.0985 1.000 1.000 433 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(2), FOS(1), JAK1(2), JAK3(2), MAP2K1(1), MAPK3(1), RAF1(1), SOS1(3) 10029991 13 13 13 7 4 1 2 4 2 0 0.910 1.000 1.000 434 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA1(1), ACADS(3), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH6A1(1), AOX1(4), BCKDHB(1), ECHS1(1), EHHADH(1), HADHA(1), MCCC1(1), MUT(1), PCCA(2), PCCB(1) 15276879 24 23 23 9 12 5 4 2 1 0 0.357 1.000 1.000 435 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ASS1(1), CKB(1), CKM(1), CKMT1B(2), CPS1(5), DAO(3), EPRS(2), GAMT(1), GATM(2), GLUD2(3), GOT2(1), NOS1(5), NOS3(3), OTC(2), PARS2(1), PRODH(1), RARS(1) 15382884 35 33 35 10 18 4 6 7 0 0 0.201 1.000 1.000 436 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AMD1(2), CBS(1), CTH(1), MARS(2), MAT1A(2), TAT(2) 8827527 10 10 9 6 5 2 0 2 1 0 0.848 1.000 1.000 437 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(2), COL4A2(3), COL4A3(1), COL4A4(7), COL4A5(3), COL4A6(3), P4HB(1), SLC23A1(1), SLC2A1(2), SLC2A3(2) 10827827 25 23 25 10 7 7 4 4 3 0 0.421 1.000 1.000 438 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 19 MAP3K1(6), MYLK(2), NCF2(2), PAK1(1), PLD1(1), PPP1R12B(1), RALBP1(1), TRIO(2), VAV1(4) 12313945 20 19 18 8 3 5 4 5 3 0 0.605 1.000 1.000 439 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 92 ANK2(8), CDR1(1), DGKI(2), FAU(1), RPL10(2), RPL11(2), RPL13A(1), RPL15(1), RPL3L(1), RPL7(1), RPLP0(1), RPS12(1), RPS21(1), RPS4X(1), RPS5(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), SLC36A2(2), TBC1D10C(1), TSPAN9(1), UBA52(1), UBC(2) 22167244 38 35 38 9 11 6 6 9 6 0 0.241 1.000 1.000 440 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 AGT(1), AKT1(1), CALM1(1), CAMK1(1), CAMK4(1), CREBBP(4), ELSPBP1(3), F2(1), GATA4(2), GSK3B(1), IGF1(2), MAP2K1(1), MAPK1(2), MAPK3(1), MYH2(9), NFATC2(2), NFATC4(2), NPPA(2), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RAF1(1), SYT1(1) 19983553 42 37 42 12 14 4 5 11 8 0 0.207 1.000 1.000 441 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B10(1), B4GALT2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PFKL(1), PGM1(1) 16526838 24 23 24 8 12 4 2 4 2 0 0.325 1.000 1.000 442 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), DARS(1), EPRS(2), FARSA(1), HARS(2), IARS(3), KARS(2), MARS(2), PARS2(1), QARS(2), RARS(1), SARS2(1), TARS(1), TARS2(1), VARS(1), VARS2(2), WARS(1), YARS2(1) 23078027 27 27 27 6 4 4 5 10 4 0 0.368 1.000 1.000 443 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG2(2), ADCY3(3), ADCY9(4), AK1(1), ARL4D(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), PLCG1(6), PLCG2(3), PRKCA(1), TRIM23(1) 15729483 33 31 33 10 11 7 3 8 4 0 0.293 1.000 1.000 444 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 26 ERBB2(1), ETS1(2), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PIWIL1(2), PIWIL2(2), PIWIL3(2), PIWIL4(1), RAF1(1), SOS1(3), SPIRE1(1), SPIRE2(1) 20599532 30 28 29 9 8 7 6 5 4 0 0.339 1.000 1.000 445 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(4), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), AOC2(1), AOX1(4), CARM1(1), DBH(1), DCT(1), DDC(3), ESCO1(1), GOT2(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), MYST4(1), PRMT8(1), TAT(2), TPO(4), TYR(1), TYRP1(2) 25323263 44 40 41 11 25 5 2 9 3 0 0.0762 1.000 1.000 446 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CYB5R1(1), GFPT1(1), GNPDA1(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), NPL(1), RENBP(1) 12184271 13 13 13 5 7 0 3 2 1 0 0.667 1.000 1.000 447 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 41 AKT1(1), EIF4B(1), FIGF(2), IGF1(2), INS(1), MAPK1(2), MAPK3(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), RICTOR(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2), TSC2(3), ULK1(1), ULK2(2), VEGFA(2), VEGFB(1), VEGFC(1) 20563540 46 40 46 13 15 10 5 12 4 0 0.186 1.000 1.000 448 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 30 MAPK1(2), MAPK13(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), SYT1(1) 12732357 18 18 18 8 5 4 4 2 3 0 0.707 1.000 1.000 449 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), AGTR2(1), ATP8A1(2), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CX3CR1(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GNRHR(1), GPR77(1), GRPR(1), LHCGR(2), MC2R(2), MC3R(4), MC4R(3), MC5R(2), NMBR(1), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), PPYR1(1), SSTR2(1), SSTR3(1), SSTR4(4), TACR3(4), TSHR(1) 22211211 66 64 66 23 42 9 3 11 1 0 0.0678 1.000 1.000 450 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), PFKFB1(2), PFKFB4(1), PMM1(1) 10201544 12 11 12 9 7 1 1 2 1 0 0.909 1.000 1.000 451 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), CALM1(1), ELK1(2), FOS(1), LYN(2), MAP2K1(1), MAP3K1(6), MAPK3(1), NFATC2(2), NFATC4(2), PLCG1(6), PPP3CB(1), PRKCA(1), RAF1(1), SOS1(3), SYT1(1), VAV1(4) 16260863 36 32 34 12 8 9 7 7 5 0 0.290 1.000 1.000 452 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2(2), BCL2A1(1), BOK(1), CASP1(2), CASP10(1), CASP9(1), CRADD(1), DAXX(3), MCL1(1), NFKB1(1), NFKBIA(1), NTRK1(1), PTPN13(1), RIPK1(1), SFRS2IP(2), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1) 18685366 23 21 23 9 5 4 1 7 6 0 0.726 1.000 1.000 453 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CDK7(1), GTF2H1(2), GTF2H4(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), TAF6(1), TAF7(1), TBP(2) 14853277 15 14 15 7 2 4 2 4 3 0 0.799 1.000 1.000 454 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 38 AKT1(1), ASAH1(1), CREB1(1), CREBBP(4), CRKL(1), DAG1(2), EGR1(3), EGR2(2), EGR3(1), ELK1(2), MAP1B(2), MAPK1(2), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), NTRK1(1), PTPN11(4), RPS6KA3(1), SRC(2) 18692731 37 35 37 12 8 8 6 8 7 0 0.371 1.000 1.000 455 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ACY3(1), ASNS(2), ASS1(1), CAD(3), CRAT(1), DARS(1), DLD(2), GAD1(1), GOT2(1), PC(2), PDHA1(1), PDHA2(3) 16104224 21 21 21 9 4 6 3 4 4 0 0.718 1.000 1.000 456 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 CEBPB(1), CLOCK(2), CRY1(1), GFRA1(1), HERPUD1(1), KLF9(1), NCKAP1(1), PER1(1), PER2(3), PIGF(1), SF3A3(1), ZFR(2) 15588634 16 15 16 6 7 2 2 2 3 0 0.615 1.000 1.000 457 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 DLD(2), IDH3A(1), PC(2), PDHA1(1), PDHA2(3), PDK4(1), PDP2(1), SUCLA2(1), SUCLG1(2) 12078594 14 13 14 7 3 6 0 4 1 0 0.735 1.000 1.000 458 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(1), APC(1), ASAH1(1), CAV3(1), DAG1(2), DLG4(3), EPHB2(3), ITPR1(5), ITPR2(3), ITPR3(5), KCNJ3(1), KCNJ5(2), MAPK1(2), PITX2(3), RYR1(4) 19660407 37 35 37 11 16 11 4 3 3 0 0.0809 1.000 1.000 459 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACPT(2), ALPI(1), ALPP(2), ALPPL2(4), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A5(5), CYP4B1(4), CYP4F8(3), PON1(2) 12436380 42 39 42 15 25 3 5 7 2 0 0.304 1.000 1.000 460 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 AGPAT1(2), AGPAT2(1), AGPAT6(1), CHAT(2), CRLS1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), ESCO1(1), GNPAT(1), GPD2(1), LCAT(1), MYST4(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1), PTDSS1(3) 28043803 42 41 42 11 16 8 2 13 3 0 0.136 1.000 1.000 461 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 36 CALM1(1), CAMK1(1), ELK1(2), GNB1(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAPK1(2), MAPK3(1), NCF1(1), NCF2(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKBIA(1), PAK1(1), PLCB1(1), PPP3CB(1), RAF1(1), SYT1(1) 15250432 32 30 30 12 9 8 4 4 7 0 0.467 1.000 1.000 462 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 46 AKT1(1), CBL(1), CDKN2A(2), FLOT1(1), GSK3B(1), INPPL1(3), IRS1(4), IRS4(2), LNPEP(2), MAPK1(2), MAPK3(1), PARD3(1), PPYR1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SORBS1(2), SOS1(3), YWHAE(2), YWHAH(1) 23287295 36 35 36 10 5 6 6 10 9 0 0.351 1.000 1.000 463 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 38 ALAS1(1), COX10(2), CP(4), EPRS(2), FECH(1), FTMT(4), HCCS(1), HMBS(1), HMOX1(1), MMAB(1), PPOX(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B7(2) 16592793 39 36 39 13 14 5 6 12 2 0 0.460 1.000 1.000 464 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AKAP1(1), AKAP11(1), AKAP4(2), AKAP5(1), AKAP6(3), AKAP8(1), AKAP9(5), CALM1(1), GNAO1(1), GNB1(1), GNG5(1), GNGT2(1), ITPR1(5), KCNJ3(1), KRAS(2), NRAS(1), PDE1A(2), PDE1C(4), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKD3(2) 49897435 78 63 76 15 27 18 8 15 10 0 0.00370 1.000 1.000 465 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 67 AKT1(1), CASP9(1), KDR(8), KRAS(2), MAP2K1(1), MAPK1(2), MAPK13(1), MAPK3(1), MAPKAPK2(1), MAPKAPK3(1), NFATC2(2), NFATC4(2), NOS3(3), NRAS(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTGS2(1), PXN(1), RAF1(1), SRC(2), VEGFA(2) 29265080 71 60 70 20 23 17 4 18 9 0 0.0482 1.000 1.000 466 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(1), ARHGEF11(2), BCL2(2), DLG4(3), LPA(4), MAP3K1(6), MAP3K5(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PIK3CB(4), PLD1(1), ROCK1(2), ROCK2(1), SRF(1) 20898391 35 30 33 10 7 13 3 6 6 0 0.291 1.000 1.000 467 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(4), ACMSD(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), AOC2(1), AOX1(4), ASMT(1), CYP19A1(2), CYP1A2(2), CYP2A13(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2D6(2), CYP2E1(1), CYP2F1(1), CYP3A4(2), CYP3A5(5), CYP4B1(4), CYP4F8(3), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), KYNU(1), MAOA(1), MAOB(2), TPH1(2), WARS(1) 23400697 62 52 61 19 36 6 5 12 3 0 0.116 1.000 1.000 468 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF2(1), EIF2AK2(1), EIF2AK3(1), EIF2B1(1), EIF2S2(1), EIF2S3(2), EIF4A1(1), EIF4G1(1), EIF4G3(1), EIF5B(1), GSPT2(2), PABPC3(4) 18717702 17 17 17 9 5 3 1 5 3 0 0.893 1.000 1.000 469 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 66 ADH1A(2), ADH1B(2), ADH1C(2), AKR1C1(1), AKR1C4(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), CYP1A2(2), CYP1B1(1), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP2F1(1), CYP2S1(1), CYP3A4(2), CYP3A43(1), CYP3A5(5), EPHX1(1), GSTA1(2), GSTA4(2), GSTA5(1), GSTK1(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B7(2) 23012612 62 55 62 20 26 8 6 19 3 0 0.236 1.000 1.000 470 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(1), ESR1(1), ESR2(3), HNF4A(4), NPM1(1), NR1H2(2), NR1I2(1), NR1I3(1), NR2C2(1), NR2F2(2), NR4A1(2), NR5A2(1), PGR(5), PPARA(1), PPARG(1), RARB(1), RORC(3), RXRA(3), THRA(1) 17953939 35 34 35 12 12 5 3 11 4 0 0.522 1.000 1.000 471 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1L(1), GTF2H1(2), GTF2H4(1), GTF2IRD1(1), TAF1(4), TAF1L(9), TAF2(3), TAF4(2), TAF6(1), TAF7(1), TAF7L(4), TBPL2(1) 15331345 30 27 30 10 8 3 3 12 4 0 0.694 1.000 1.000 472 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(5), ACYP1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1) 15714288 27 26 27 10 13 5 0 7 2 0 0.483 1.000 1.000 473 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(1), ALG10B(1), ALG3(2), B4GALT2(1), DPM1(1), FUT8(1), MAN1A1(1), MGAT2(1), MGAT5(1), MGAT5B(1), ST6GAL1(1) 18093370 12 12 12 8 5 3 0 2 2 0 0.855 1.000 1.000 474 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3), WAS(1) 22331141 43 39 43 15 21 7 7 5 3 0 0.295 1.000 1.000 475 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(2), CTTN(2), EZR(4), FYN(1), HCLS1(3), ITGB1(1), KRT18(2), LY96(2), NCL(1), OCLN(1), PRKCA(1), ROCK1(2), ROCK2(1), TLR5(2), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3), WAS(1) 22331141 43 39 43 15 21 7 7 5 3 0 0.295 1.000 1.000 476 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA1(1), ACADS(3), ACADVL(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), ADH1A(2), ADH1B(2), ADH1C(2), ALDH1A3(1), ALDH3A1(2), CPT1A(1), CPT1C(1), CPT2(1), CYP4A11(4), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1) 20808895 29 27 29 10 12 4 2 7 4 0 0.386 1.000 1.000 477 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 51 BCL2(2), BIRC2(1), BIRC3(1), CASP9(1), CHUK(1), CRADD(1), DAXX(3), GSN(1), LMNB2(1), MAP3K1(6), MAP3K5(1), MDM2(2), NFKB1(1), NFKBIA(1), NUMA1(3), PRKCD(3), PRKDC(3), PSEN1(1), RIPK1(1), SPTAN1(3), TNFRSF1A(1), TNFRSF1B(1), TRAF1(1) 28989403 40 37 37 10 9 7 6 10 8 0 0.183 1.000 1.000 478 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG2(2), AKT1(1), ANGPTL2(1), CFL2(1), FLNA(5), FLNC(3), FSCN2(1), GDI1(1), MYH2(9), MYLK(2), PAK1(1), PAK4(2), PAK7(1), ROCK1(2), ROCK2(1), RPS4X(1), VASP(1) 20502607 35 32 34 13 21 3 3 3 5 0 0.307 1.000 1.000 479 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 63 ATM(4), ATR(4), CASP9(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CCNG1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), DDB2(1), GADD45B(1), GTSE1(1), IGF1(2), LRDD(1), MDM2(2), MDM4(1), PPM1D(1), RPRM(1), RRM2(1), SERPINB5(1), SERPINE1(2), SESN1(1), SESN3(1), SFN(1), THBS1(2), TSC2(3) 27128092 47 45 47 14 8 9 7 14 9 0 0.370 1.000 1.000 480 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 AGPAT1(2), AGPAT2(1), CHAT(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), GNPAT(1), GPD2(1), LCAT(1), LGALS13(1), PCYT1A(2), PCYT1B(1), PISD(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB2(3), PLCG1(6), PLCG2(3) 21394404 44 39 44 15 16 8 2 13 5 0 0.328 1.000 1.000 481 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(1), AXIN1(3), CCND2(2), CCND3(1), DVL1(1), DVL2(2), DVL3(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LDLR(3), PPP2R5E(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1) 25259832 38 34 37 12 10 6 6 9 7 0 0.390 1.000 1.000 482 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 72 AKT1(1), BTK(1), CSF2(2), FCER1A(2), FYN(1), GAB2(1), IL3(1), INPP5D(3), KRAS(2), LYN(2), MAP2K1(1), MAP2K3(3), MAPK1(2), MAPK13(1), MAPK3(1), NRAS(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCG1(6), PLCG2(3), PRKCA(1), PRKCD(3), PRKCE(1), RAF1(1), SOS1(3), VAV1(4), VAV2(2), VAV3(1) 29181446 74 60 72 24 24 15 10 16 9 0 0.238 1.000 1.000 483 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 89 ACVR1C(2), ACVRL1(1), AMHR2(1), BMP2(1), BMP4(1), BMP5(4), BMP6(1), BMPR2(1), CDKN2B(2), CHRD(1), CREBBP(4), CUL1(3), DCN(1), E2F4(1), EP300(1), GDF5(1), GDF6(1), GDF7(1), ID1(1), IFNG(2), INHBA(1), INHBE(1), LEFTY2(2), MAPK1(2), MAPK3(1), PITX2(3), PPP2R1B(1), RBL1(2), ROCK1(2), ROCK2(1), SMAD4(1), SMAD7(1), SMURF1(2), SP1(1), TFDP1(1), TGFBR1(2), TGFBR2(2), THBS1(2), THBS3(1), THBS4(2), ZFYVE16(1), ZFYVE9(1) 42205216 64 58 64 15 15 13 9 16 11 0 0.0668 1.000 1.000 484 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 47 CD36(1), CREBBP(4), EHHADH(1), EP300(1), FABP1(1), HSD17B4(1), INS(1), MAPK1(2), MAPK3(1), ME1(1), NCOA1(1), NCOR1(1), NCOR2(2), NFKBIA(1), NR0B2(1), NRIP1(2), PPARA(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PTGS2(1), RXRA(3), SP1(1) 24598649 31 31 31 10 9 6 2 7 7 0 0.318 1.000 1.000 485 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 98 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CALM1(1), CAMK2A(1), CREB1(1), CREB3L1(1), CREB3L3(3), CREB3L4(1), CREBBP(4), DCT(1), DVL1(1), DVL2(2), DVL3(1), EP300(1), FZD1(1), FZD10(3), FZD9(1), GNAO1(1), GSK3B(1), KIT(3), KITLG(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), TCF7L2(1), TYR(1), TYRP1(2), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1) 46159722 85 75 83 23 32 18 11 14 10 0 0.0403 1.000 1.000 486 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 83 CHUK(1), CREB1(1), DAXX(3), ELK1(2), FOS(1), IKBKB(1), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPKAPK2(1), MAPKAPK3(1), MAX(2), MEF2A(2), MEF2D(1), NFKB1(1), NFKBIA(1), PAK1(1), RAF1(1), RIPK1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), SP1(1), STAT1(2), TGFBR1(2) 40278599 66 60 64 17 19 18 8 12 9 0 0.0629 1.000 1.000 487 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 80 ACVRL1(1), AKT1(1), AURKB(1), BMPR2(1), BUB1(1), CDKL1(2), CDKL2(2), CSNK2B(2), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), NEK1(2), NEK3(2), OCRL(2), PAK4(2), PIK3C2A(1), PIK3C2B(1), PIK3CB(4), PIK3CG(7), PIM2(2), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3), PLK3(1), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), PRKG1(1), RAF1(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TGFBR1(2) 46320862 92 77 91 24 27 19 12 21 13 0 0.0579 1.000 1.000 488 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 92 BCL2(2), CABIN1(5), CALM1(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CEBPB(1), CREBBP(4), CSF2(2), CSNK2B(2), EGR2(2), EGR3(1), EP300(1), FCER1A(2), FOS(1), GATA4(2), GRLF1(2), GSK3B(1), IFNB1(1), IFNG(2), IL1B(1), IL3(1), IL6(1), KPNA5(1), MEF2A(2), MEF2D(1), MYF5(2), NFATC2(2), NFATC4(2), NFKB2(1), NFKBIE(2), NUP214(2), OPRD1(1), PAK1(1), PPP3CB(1), PTPRC(2), RPL13A(1), SFN(1), SP1(1), SP3(1), TRPV6(7), VAV1(4), VAV2(2), VAV3(1) 38766387 78 67 78 23 20 13 11 18 16 0 0.130 1.000 1.000 489 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(5), ACACB(7), ACOT12(1), ACYP1(1), ALDH1A3(1), ALDH3A1(2), DLD(2), HAGH(1), LDHAL6A(1), LDHAL6B(1), ME1(1), ME2(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PKLR(1) 19872097 34 34 34 12 15 5 1 11 2 0 0.455 1.000 1.000 490 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(1), CDKN1B(1), CDKN2A(2), CREB1(1), GSK3B(1), IGF1(2), INPPL1(3), IRS1(4), IRS4(2), MET(3), PAK1(1), PAK4(2), PAK7(1), PARD3(1), PREX1(5), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), SFN(1), SOS1(3), TSC2(3), YWHAE(2), YWHAH(1) 31572288 44 39 44 13 11 6 8 9 10 0 0.379 1.000 1.000 491 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 65 BCL2(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(1), CASP9(1), CHUK(1), GZMB(2), IKBKB(1), IRF1(1), IRF2(1), IRF4(2), IRF5(1), IRF6(2), MAP3K1(6), MDM2(2), NFKB1(1), NFKBIA(1), NFKBIE(2), PLEKHG5(1), RIPK1(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFSF10(2), TRAF1(1) 24130661 39 36 37 13 11 9 4 8 7 0 0.324 1.000 1.000 492 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 69 CALM1(1), DGKA(1), DGKB(1), DGKD(5), DGKE(2), DGKG(2), DGKH(1), DGKI(2), DGKQ(1), DGKZ(1), INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5D(3), INPP5E(1), INPPL1(3), ITGB1BP3(1), ITPR1(5), ITPR2(3), ITPR3(5), OCRL(2), PI4KA(1), PI4KB(2), PIK3C2A(1), PIK3C2B(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PRKCA(1), PRKCG(2), SYNJ2(3) 50314460 99 77 99 25 40 17 6 23 13 0 0.0174 1.000 1.000 493 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 51 AKR1C4(2), ARSE(3), CARM1(1), CYP11B1(1), CYP11B2(2), CYP19A1(2), HSD11B1(2), HSD17B3(1), LCMT1(1), LCMT2(1), METTL6(1), PRMT8(1), SRD5A1(1), SRD5A2(1), STS(2), SULT2B1(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B7(2) 20062968 43 37 43 17 17 8 5 10 3 0 0.492 1.000 1.000 494 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 78 AIFM1(2), AKT1(1), ATM(4), BCL2(2), BIRC2(1), BIRC3(1), CAPN1(2), CASP10(1), CASP9(1), CHUK(1), CSF2RB(4), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL3(1), IL3RA(2), IRAK1(2), IRAK2(1), IRAK3(3), NFKB1(1), NFKB2(1), NFKBIA(1), NTRK1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PPP3CB(1), PRKAR1B(1), PRKAR2B(1), RIPK1(1), TNFRSF1A(1), TNFSF10(2) 33798138 64 58 63 20 20 12 7 15 10 0 0.248 1.000 1.000 495 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AANAT(1), ABP1(4), ACMSD(1), ALDH1A3(1), ALDH3A1(2), AOC2(1), AOX1(4), ASMT(1), CARM1(1), CYP1A2(2), CYP1B1(1), DDC(3), ECHS1(1), EHHADH(1), HADHA(1), HSD17B4(1), KYNU(1), LCMT1(1), LCMT2(1), MAOA(1), MAOB(2), METTL6(1), NFX1(1), OGDHL(3), PRMT8(1), TPH1(2), WARS(1) 25781585 41 38 40 14 21 4 1 11 4 0 0.362 1.000 1.000 496 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 107 ABL1(2), ANAPC1(1), ANAPC4(2), ANAPC7(1), ATM(4), ATR(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDC23(2), CDC27(1), CDK7(1), CDKN1A(1), CDKN1B(1), CDKN2A(2), CDKN2B(2), CDKN2C(3), CHEK1(3), CREBBP(4), CUL1(3), DBF4(1), EP300(1), ESPL1(3), FZR1(1), GADD45B(1), GSK3B(1), HDAC2(3), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), ORC3L(1), ORC5L(1), PRKDC(3), RBL1(2), SFN(1), SKP2(1), SMAD4(1), SMC1A(6), SMC1B(2), TFDP1(1), WEE1(1), YWHAE(2), YWHAH(1) 57047634 96 80 96 23 9 21 10 34 22 0 0.102 1.000 1.000 497 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACAA1(1), ACOX2(1), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), APOA5(1), AQP7(1), CD36(1), CPT1A(1), CPT1C(1), CPT2(1), CYP27A1(1), CYP4A11(4), CYP7A1(1), CYP8B1(2), EHHADH(1), FABP1(1), FABP6(1), GK2(1), ME1(1), MMP1(2), OLR1(1), PCK1(3), PLTP(1), PPARA(1), PPARG(1), RXRA(3), SLC27A1(1), SLC27A2(6), SLC27A6(4), SORBS1(2), UBC(2) 27848836 52 46 52 17 23 7 5 13 4 0 0.237 1.000 1.000 498 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(1), BTK(1), CD19(1), CDKN2A(2), FLOT1(1), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), NR0B2(1), PITX2(3), PLCG2(3), PREX1(5), PTPRC(2), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), TEC(1), VAV1(4) 22354448 44 41 44 16 16 12 4 4 8 0 0.262 1.000 1.000 499 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 APH1A(2), CREBBP(4), CTBP2(3), DLL1(1), DTX2(1), DTX3L(1), DTX4(2), DVL1(1), DVL2(2), DVL3(1), EP300(1), HDAC2(3), HES1(1), JAG1(3), JAG2(4), LFNG(1), MAML1(2), NCOR2(2), NCSTN(1), NOTCH2(5), NOTCH3(1), NOTCH4(2), PSEN1(1), RBPJL(3) 29877976 48 43 48 16 10 10 9 8 11 0 0.411 1.000 1.000 500 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(2), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), CHUK(1), CSK(1), CXCL1(1), F11R(1), IKBKB(1), LYN(2), MAPK13(1), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NOD1(2), PAK1(1), PLCG1(6), PLCG2(3), PTPN11(4), PTPRZ1(3), SRC(2), TJP1(3) 28729642 52 43 52 17 12 11 6 16 7 0 0.350 1.000 1.000 501 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 185 ACTN1(2), ACTN3(1), AKT1(1), ARHGAP5(3), BCL2(2), BIRC2(1), BIRC3(1), CAV3(1), CCND2(2), CCND3(1), COL11A1(2), COL11A2(7), COL1A1(1), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), CRKL(1), DOCK1(2), EGF(3), ELK1(2), ERBB2(1), FIGF(2), FLNA(5), FLNB(2), FLNC(3), FLT1(5), FN1(3), FYN(1), GRLF1(2), GSK3B(1), HGF(1), IGF1(2), IGF1R(3), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KDR(8), LAMA1(8), LAMA2(7), LAMA3(3), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), MAP2K1(1), MAPK1(2), MAPK3(1), MET(3), MYLK(2), PAK1(1), PAK4(2), PAK7(1), PARVG(1), PDGFD(2), PDGFRB(3), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP5K1C(1), PPP1CC(1), PRKCA(1), PRKCG(2), PXN(1), RAF1(1), RELN(13), ROCK1(2), ROCK2(1), SHC4(1), SOS1(3), SRC(2), THBS1(2), THBS3(1), THBS4(2), TLN2(2), TNC(1), TNN(1), TNXB(3), VASP(1), VAV1(4), VAV2(2), VAV3(1), VEGFA(2), VEGFB(1), VEGFC(1), VWF(7), ZYX(2) 152986838 298 168 295 123 102 58 33 65 40 0 0.472 1.000 1.000 502 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 166 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY7(1), ADCY8(2), ADCY9(4), AGTR1(1), ATP2A1(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), AVPR1A(2), AVPR1B(1), BDKRB1(1), BST1(1), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CALM1(1), CAMK2A(1), CAMK4(1), CCKAR(1), CD38(1), CHRM1(1), CHRM2(3), CHRM3(1), CYSLTR2(1), DRD1(1), ERBB2(1), GRIN2A(10), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(2), GRPR(1), HRH2(3), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), ITPR1(5), ITPR2(3), ITPR3(5), LHCGR(2), MYLK(2), NOS1(5), NOS3(3), NTSR1(3), P2RX2(1), P2RX5(1), PDE1A(2), PDE1C(4), PDGFRB(3), PHKA1(2), PHKG1(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), PPID(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTAFR(1), PTGFR(1), PTK2B(3), RYR1(4), RYR2(30), RYR3(17), TACR3(4), TNNC2(1), TRPC1(1), VDAC1(1), VDAC2(1) 113472640 246 163 245 86 130 30 19 45 22 0 0.0348 1.000 1.000 503 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 135 COL11A1(2), COL11A2(7), COL17A1(3), COL1A1(1), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DES(3), DSC1(3), DSC2(3), DSC3(3), DSG1(2), DSG3(9), DSG4(5), FN1(3), GJA10(1), GJA9(1), GJB3(2), GJB4(1), GJC1(1), GJC3(1), GJD2(3), ITGB4(3), KRT1(1), KRT12(2), KRT13(3), KRT14(1), KRT15(2), KRT16(2), KRT17(1), KRT18(2), KRT2(1), KRT20(2), KRT23(1), KRT24(1), KRT25(3), KRT28(1), KRT31(1), KRT32(1), KRT33A(2), KRT33B(1), KRT34(2), KRT35(1), KRT36(1), KRT37(4), KRT38(1), KRT39(2), KRT4(1), KRT40(2), KRT6B(1), KRT74(1), KRT75(2), KRT76(1), KRT79(3), KRT8(1), KRT81(1), KRT84(2), KRT86(1), KRT9(3), LAMA1(8), LAMA2(7), LAMA3(3), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), LMNB2(1), NES(1), RELN(13), THBS1(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNXB(3), VWF(7) 105264702 246 162 245 113 108 47 23 42 26 0 0.690 1.000 1.000 504 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 232 ADCYAP1R1(1), ADRA2B(1), ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), C5AR1(3), CALCRL(1), CCKAR(1), CGA(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CRHR2(2), CTSG(3), CYSLTR2(1), DRD1(1), DRD2(1), DRD3(1), DRD5(7), F2(1), F2RL3(2), FSHR(1), GABBR2(1), GABRA2(1), GABRA3(2), GABRA4(4), GABRA5(3), GABRB1(1), GABRB3(6), GABRD(1), GABRE(2), GABRG1(2), GABRG2(4), GABRP(1), GABRQ(1), GABRR2(1), GALR1(1), GH1(1), GHRHR(1), GHSR(2), GLP1R(1), GLP2R(2), GLRA1(1), GLRA2(1), GLRA3(1), GNRHR(1), GPR156(1), GPR35(1), GPR50(1), GPR83(2), GRIA1(2), GRIA3(3), GRID1(1), GRID2(2), GRIK1(2), GRIK2(1), GRIK3(4), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRIN3A(2), GRIN3B(1), GRM1(3), GRM3(9), GRM4(2), GRM5(2), GRM6(3), GRM7(2), GRM8(5), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LEPR(1), LHCGR(2), MC2R(2), MC3R(4), MC4R(3), MC5R(2), MCHR1(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPBWR1(1), NPBWR2(2), NPFFR2(2), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), P2RX2(1), P2RX5(1), P2RY10(1), P2RY2(1), P2RY4(1), P2RY8(3), PARD3(1), PPYR1(1), PRLHR(1), PRSS1(1), PTAFR(1), PTGER4(1), PTGFR(1), PTH2R(1), RXFP1(3), RXFP2(1), SSTR2(1), SSTR3(1), SSTR4(4), SSTR5(1), TAAR1(1), TACR3(4), THRA(1), TRPV1(2), TSHR(1), UTS2R(1), VIPR2(1) 92617072 257 161 256 116 147 32 19 49 10 0 0.352 1.000 1.000 505 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(2), CD36(1), CD44(3), COL11A1(2), COL11A2(7), COL1A1(1), COL2A1(2), COL3A1(4), COL4A1(2), COL4A2(3), COL4A4(7), COL4A6(3), COL5A1(3), COL5A2(2), COL5A3(1), COL6A1(3), COL6A2(5), COL6A3(13), COL6A6(4), DAG1(2), FN1(3), FNDC1(3), FNDC4(1), HSPG2(8), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAV(1), ITGB1(1), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), LAMA1(8), LAMA2(7), LAMA3(3), LAMA4(1), LAMA5(6), LAMB1(3), LAMB3(5), LAMB4(5), LAMC1(2), LAMC2(1), LAMC3(6), RELN(13), SDC1(1), SDC2(1), SDC4(1), SV2B(2), SV2C(2), THBS1(2), THBS3(1), THBS4(2), TNC(1), TNN(1), TNXB(3), VWF(7) 95105189 197 139 197 82 74 44 21 32 26 0 0.369 1.000 1.000 506 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1C(2), AKT1(1), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1F(1), CACNA1H(4), CACNA1I(3), CACNA1S(7), CACNA2D1(7), CACNA2D2(2), CACNA2D3(2), CACNA2D4(1), CACNB3(2), CACNG2(1), CACNG3(2), CHUK(1), CRKL(1), DAXX(3), DDIT3(1), DUSP10(1), DUSP5(1), EGF(3), ELK1(2), ELK4(1), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(2), FLNA(5), FLNB(2), FLNC(3), FOS(1), GADD45B(1), IKBKB(1), IL1A(1), IL1B(1), IL1R1(2), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP4K1(2), MAP4K2(1), MAP4K3(3), MAP4K4(2), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), MAPKAPK2(1), MAPKAPK3(1), MAX(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NR4A1(2), NRAS(1), NTF3(1), NTRK1(1), PAK1(1), PDGFRB(3), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PPM1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PTPRR(3), RAF1(1), RAPGEF2(1), RASGRF1(3), RASGRF2(2), RASGRP1(1), RASGRP2(1), RASGRP4(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA5(1), RPS6KA6(2), SOS1(3), SRF(1), STK3(1), TAOK1(1), TAOK2(1), TAOK3(2), TGFBR1(2), TGFBR2(2), TNFRSF1A(1), ZAK(3) 117262834 208 137 202 79 78 41 23 42 24 0 0.300 1.000 1.000 507 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 198 ABI2(1), ACTN1(2), ACTN3(1), APC(1), APC2(3), ARHGEF12(1), ARHGEF6(2), ARHGEF7(2), ARPC2(1), BDKRB1(1), CFL2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CRKL(1), CSK(1), DIAPH2(3), DIAPH3(2), DOCK1(2), EGF(3), EZR(4), F2(1), FGD3(2), FGF13(1), FGF14(2), FGF18(2), FGF7(1), FGFR1(1), FGFR2(1), FGFR3(3), FGFR4(2), FN1(3), GRLF1(2), GSN(1), INS(1), IQGAP2(1), IQGAP3(3), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MSN(1), MYH10(1), MYH14(3), MYH9(3), MYLK(2), NCKAP1(1), NCKAP1L(1), NRAS(1), PAK1(1), PAK4(2), PAK7(1), PDGFRB(3), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PPP1CC(1), PPP1R12B(1), PXN(1), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SSH1(2), SSH2(1), TIAM2(5), TMSL3(1), VAV1(4), VAV2(2), VAV3(1), WAS(1) 114054954 190 134 187 78 71 24 20 51 24 0 0.742 1.000 1.000 508 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP1A4(2), ATP2A3(2), ATP2B2(4), ATP2B3(2), CACNA1A(1), CACNA1B(6), CACNA1C(5), CACNA1D(4), CACNA1E(5), CACNA1S(7), CACNB3(2), CALM1(1), CAMK1(1), CAMK2A(1), CAMK4(1), CASQ2(1), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), GJB3(2), GJB4(1), GNAO1(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), ITPR1(5), ITPR2(3), ITPR3(5), KCNB1(2), KCNJ3(1), KCNJ5(2), MIB1(4), NME7(2), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), PRKD1(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(17), SFN(1), YWHAH(1) 80603643 184 133 182 57 84 30 17 36 17 0 0.0145 1.000 1.000 509 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 248 AMHR2(1), BMP2(1), BMPR2(1), CCL13(1), CCL14(1), CCL19(1), CCL2(1), CCL24(2), CCL3(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CD70(1), CSF1R(1), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), CX3CL1(1), CX3CR1(2), CXCL1(1), CXCL6(1), EDA(1), EDAR(1), EGF(3), EPO(1), FLT1(5), FLT3(4), FLT4(2), GDF5(1), GH1(1), HGF(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL15RA(1), IL17RA(2), IL17RB(1), IL18R1(2), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), INHBA(1), INHBE(1), KDR(8), KIT(3), KITLG(1), LEPR(1), MET(3), MPL(3), OSM(1), OSMR(2), PDGFRB(3), PPBP(1), RELT(1), TGFBR1(2), TGFBR2(2), TNFRSF11A(2), TNFRSF19(1), TNFRSF1A(1), TNFRSF1B(1), TNFRSF25(1), TNFRSF4(2), TNFRSF8(2), TNFRSF9(1), TNFSF10(2), TNFSF11(1), TNFSF14(2), TNFSF18(1), TNFSF8(1), TNFSF9(3), TPO(4), VEGFA(2), VEGFB(1), VEGFC(1), XCL1(2), XCR1(1) 73099447 170 122 167 78 70 22 11 49 18 0 0.786 1.000 1.000 510 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ACTA2(1), ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), ATP2A3(2), CACNB3(2), CALCA(1), CALM1(1), CAMK2A(1), CORIN(2), DGKZ(1), FOS(1), GNB1(1), GNB4(1), GNG2(1), GNG5(1), GUCY1A3(1), IL1B(1), IL6(1), ITPR1(5), ITPR2(3), ITPR3(5), MIB1(4), NFKB1(1), NOS1(5), NOS3(3), PDE4B(1), PLCD1(3), PLCG1(6), PLCG2(3), PRKAR1B(1), PRKAR2B(1), PRKCA(1), PRKCD(3), PRKCE(1), PRKCQ(2), PRKD1(1), RAMP3(1), RGS1(1), RGS14(1), RGS3(2), RGS4(2), RGS6(1), RGS9(3), RYR1(4), RYR2(30), RYR3(17), SFN(1), SP1(1), TNXB(3), YWHAH(1) 74334597 161 122 160 49 73 23 13 34 18 0 0.0166 1.000 1.000 511 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTN1(2), ACTN3(1), AKT1(1), AMOTL1(1), CGN(1), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CSDA(1), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), CTTN(2), EPB41(1), EPB41L2(1), EPB41L3(5), F11R(1), HCLS1(3), INADL(2), KRAS(2), LLGL1(2), MAGI1(2), MAGI2(2), MAGI3(1), MLLT4(3), MPDZ(1), MYH1(6), MYH10(1), MYH11(5), MYH13(8), MYH14(3), MYH15(3), MYH2(9), MYH3(2), MYH4(5), MYH6(2), MYH7(2), MYH7B(3), MYH8(7), MYH9(3), NRAS(1), OCLN(1), PARD3(1), PARD6B(2), PPM1J(2), PPP2R1B(1), PPP2R3A(2), PRKCA(1), PRKCD(3), PRKCE(1), PRKCG(2), PRKCQ(2), SPTAN1(3), SRC(2), SYMPK(3), TJAP1(2), TJP1(3), TJP3(5), ZAK(3) 82436916 151 113 149 41 70 23 14 27 17 0 0.0212 1.000 1.000 512 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 162 ADRA2C(2), AGTR1(1), AGTR2(1), AVPR1A(2), AVPR1B(1), AVPR2(1), BDKRB1(1), CCBP2(1), CCKAR(1), CCR1(1), CCR3(1), CCR4(1), CCR5(1), CCR6(1), CCR8(2), CHML(2), CHRM1(1), CHRM2(3), CHRM3(1), CHRM4(2), CNR2(1), CX3CR1(2), DRD1(1), DRD2(1), DRD3(1), DRD5(7), F2RL3(2), FSHR(1), GALR1(1), GALT(1), GHSR(2), GPR17(1), GPR174(1), GPR27(1), GPR35(1), GPR37(2), GPR4(2), GPR50(1), GPR6(1), GPR77(1), GPR83(2), GPR85(2), GRPR(1), HCRTR1(1), HCRTR2(1), HRH2(3), HRH3(3), HTR1A(1), HTR1B(1), HTR1D(1), HTR1E(2), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR5A(4), HTR7(3), LHCGR(2), MC3R(4), MC4R(3), MC5R(2), MTNR1B(1), NMBR(1), NMUR1(1), NMUR2(4), NPY2R(1), NPY5R(3), NTSR1(3), OPRD1(1), OPRK1(1), OPRL1(2), OPRM1(2), OR1C1(1), OR1F1(1), OR2H1(3), OR7A5(1), OR7C1(1), P2RY10(1), P2RY2(1), PPYR1(1), PTAFR(1), PTGER4(1), PTGFR(1), RGR(1), SSTR2(1), SSTR3(1), SSTR4(4), SUCNR1(1) 51645770 139 108 138 60 91 17 7 19 5 0 0.139 1.000 1.000 513 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 125 ABL1(2), ABLIM3(4), ARHGEF12(1), CFL2(1), DCC(6), DPYSL5(2), EFNA3(1), EFNA5(2), EFNB1(1), EFNB2(1), EFNB3(1), EPHA1(4), EPHA3(3), EPHA4(1), EPHA5(4), EPHA6(4), EPHA7(3), EPHA8(4), EPHB1(2), EPHB2(3), EPHB4(2), EPHB6(4), FES(1), FYN(1), GSK3B(1), ITGB1(1), KRAS(2), L1CAM(5), LRRC4C(2), MAPK1(2), MAPK3(1), MET(3), NFATC2(2), NFATC4(2), NGEF(1), NRAS(1), NRP1(1), NTN1(2), NTN4(3), NTNG1(1), PAK1(1), PAK4(2), PAK7(1), PLXNA1(1), PLXNA2(3), PLXNA3(1), PLXNB3(1), PLXNC1(1), PPP3CB(1), RGS3(2), ROBO1(3), ROBO2(2), ROCK1(2), ROCK2(1), SEMA4A(1), SEMA4C(1), SEMA4D(1), SEMA4F(2), SEMA5B(1), SEMA6B(1), SEMA6D(1), SEMA7A(1), SLIT2(3), SLIT3(9), SRGAP1(2), SRGAP3(1), UNC5A(1), UNC5C(3), UNC5D(1) 83118926 139 108 137 55 39 27 19 38 16 0 0.566 1.000 1.000 514 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 CADM1(1), CADM3(1), CD2(1), CD22(6), CD276(1), CD28(1), CD4(1), CD58(1), CD6(2), CD86(2), CD8A(1), CDH15(2), CDH4(2), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CNTN1(1), CNTN2(2), CNTNAP1(1), F11R(1), GLG1(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), ICAM1(1), ICAM2(1), ICOSLG(2), ITGA4(3), ITGA8(1), ITGA9(2), ITGAM(5), ITGAV(1), ITGB1(1), ITGB2(4), ITGB7(3), ITGB8(1), L1CAM(5), MAG(3), MPZL1(2), NCAM1(2), NEGR1(2), NEO1(1), NFASC(1), NLGN1(1), NLGN3(1), NRCAM(2), NRXN1(5), NRXN2(1), NRXN3(3), OCLN(1), PDCD1(1), PTPRC(2), PTPRF(5), PTPRM(3), PVR(1), PVRL1(2), PVRL2(1), SDC1(1), SDC2(1), SDC4(1), SELE(2), SELP(2), SELPLG(2), SIGLEC1(2), VCAM1(1), VCAN(3) 61929128 130 102 130 62 62 14 13 28 13 0 0.778 1.000 1.000 515 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA2(1), ACTN3(1), DES(3), DMD(11), FAM48A(2), MYBPC3(1), MYH3(2), MYH6(2), MYH7(2), MYH8(7), MYL3(1), MYOM1(2), NEB(6), TMOD1(1), TNNC2(1), TNNT1(3), TNNT2(1), TPM3(1), TTN(94) 58581110 142 102 140 34 60 16 12 40 14 0 0.0225 1.000 1.000 516 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(1), CBL(1), CBLB(1), CCND2(2), CCND3(1), CREBBP(4), CSF2(2), CSF2RA(1), CSF2RB(4), CSF3R(1), EP300(1), EPO(1), GH1(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), IFNW1(1), IL12B(2), IL12RB1(2), IL12RB2(2), IL13RA2(1), IL15RA(1), IL20(1), IL21R(2), IL22(2), IL26(2), IL28B(1), IL28RA(1), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), IRF9(1), JAK1(2), JAK2(1), JAK3(2), LEPR(1), MPL(3), OSM(1), OSMR(2), PIAS1(1), PIAS3(1), PIAS4(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PIM1(1), PTPN11(4), PTPN6(1), SOCS1(1), SOCS4(1), SOS1(3), SPRY3(2), STAM2(1), STAT1(2), STAT2(1), STAT3(1), STAT4(2), STAT6(1), TPO(4), TYK2(3) 60254473 127 98 126 45 46 22 11 34 14 0 0.321 1.000 1.000 517 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 128 ACACA(5), ACACB(7), AKT1(1), CALM1(1), CBL(1), CBLB(1), CRKL(1), ELK1(2), EXOC7(2), FBP1(2), FBP2(1), FLOT1(1), FOXO1(1), G6PC(1), GSK3B(1), IKBKB(1), INPP5D(3), INS(1), INSR(2), IRS1(4), IRS4(2), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PCK1(3), PDE3A(3), PDE3B(3), PFKL(1), PHKA1(2), PHKG1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PKLR(1), PPP1CC(1), PPP1R3A(7), PRKAG2(1), PRKAG3(1), PRKAR1B(1), PRKAR2B(1), PRKX(1), PTPRF(5), PYGB(2), PYGL(1), PYGM(1), RAF1(1), RHOQ(1), SH2B2(1), SHC4(1), SOCS1(1), SOCS4(1), SORBS1(2), SOS1(3), SREBF1(1), TRIP10(1), TSC2(3) 66370419 118 95 117 41 42 20 10 37 9 0 0.293 1.000 1.000 518 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CSNK1D(1), DRD1(1), DRD2(1), EGF(3), GJD2(3), GRM1(3), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), HTR2A(1), HTR2C(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MAPK7(1), NPR1(1), NRAS(1), PDGFD(2), PDGFRB(3), PLCB1(1), PLCB2(3), PLCB4(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), PRKX(1), RAF1(1), SOS1(3), SRC(2), TJP1(3), TUBA1A(1), TUBA1B(1), TUBA3C(6), TUBA3D(1), TUBA4A(1), TUBA8(1), TUBB4(3), TUBB4Q(3) 54296036 114 93 112 38 50 22 9 19 14 0 0.111 1.000 1.000 519 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 108 ACTN1(2), ACTN3(1), ARHGAP5(3), CDH5(3), CLDN14(2), CLDN15(1), CLDN17(1), CLDN18(1), CLDN19(1), CLDN4(1), CLDN6(1), CLDN9(1), CTNNA1(2), CTNNA2(2), CTNNA3(2), CYBB(1), EZR(4), F11R(1), GRLF1(2), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(4), MAPK13(1), MLLT4(3), MMP9(2), MSN(1), NCF1(1), NCF2(2), NOX3(4), OCLN(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PXN(1), RAPGEF3(1), RAPGEF4(1), RASSF5(1), ROCK1(2), ROCK2(1), SIPA1(1), TXK(1), VASP(1), VAV1(4), VAV2(2), VAV3(1), VCAM1(1) 51497384 116 92 115 51 48 13 11 31 13 0 0.754 1.000 1.000 520 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 94 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), CACNA1C(5), CACNA1D(4), CACNA1F(1), CACNA1S(7), CALM1(1), CAMK2A(1), CGA(1), ELK1(2), GNRHR(1), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAP2K3(3), MAP3K1(6), MAP3K4(3), MAPK1(2), MAPK13(1), MAPK3(1), MAPK7(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PLD1(1), PRKCA(1), PRKCD(3), PRKX(1), PTK2B(3), RAF1(1), SOS1(3), SRC(2) 53483380 108 90 104 30 46 27 7 18 10 0 0.0150 1.000 1.000 521 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 123 CD244(1), CSF2(2), FYN(1), GZMB(2), ICAM1(1), ICAM2(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IFNG(2), IFNGR1(1), IFNGR2(3), ITGB2(4), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR3DL1(3), KLRC1(1), KLRC3(4), KLRD1(1), KLRK1(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), MICB(1), NCR1(2), NFATC2(2), NFATC4(2), NRAS(1), PAK1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PPP3CB(1), PRKCA(1), PRKCG(2), PTK2B(3), PTPN11(4), PTPN6(1), RAF1(1), SH2D1A(1), SH2D1B(2), SHC4(1), SOS1(3), TNFSF10(2), ULBP1(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3) 46217944 112 87 111 45 31 17 17 32 15 0 0.556 1.000 1.000 522 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), ADCY9(4), AK1(1), AK5(1), AK7(5), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GMPR2(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NME7(2), NPR1(1), NT5C1B(2), NT5E(2), NUDT2(1), PDE10A(1), PDE11A(2), PDE1A(2), PDE1C(4), PDE2A(1), PDE3B(3), PDE4A(2), PDE4B(1), PDE8A(1), PDE8B(1), PFAS(1), PKLR(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), PRPS1L1(2), PRPS2(2), RRM2(1), XDH(3) 69759151 106 86 105 31 43 22 11 20 10 0 0.0513 1.000 1.000 523 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 83 ANPEP(2), CD19(1), CD1B(1), CD1D(4), CD1E(2), CD2(1), CD22(6), CD33(5), CD36(1), CD37(1), CD38(1), CD3E(2), CD3G(1), CD4(1), CD44(3), CD5(2), CD55(1), CD59(1), CD7(2), CD8A(1), CR2(4), CSF1R(1), CSF2(2), CSF2RA(1), CSF3R(1), DNTT(2), EPO(1), FCER2(1), FLT3(4), GYPA(1), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL3(1), IL3RA(2), IL4R(7), IL5RA(1), IL6(1), IL7(1), IL7R(2), ITGA1(2), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGAM(5), ITGB3(1), KIT(3), KITLG(1), MME(1), THPO(1), TPO(4) 34810141 102 83 101 36 49 12 6 19 16 0 0.223 1.000 1.000 524 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 142 APC(1), APC2(3), AXIN1(3), AXIN2(1), BTRC(1), CAMK2A(1), CCND2(2), CCND3(1), CHD8(9), CREBBP(4), CSNK2B(2), CTBP2(3), CUL1(3), CXXC4(1), DAAM2(1), DKK1(1), DKK2(3), DVL1(1), DVL2(2), DVL3(1), EP300(1), FBXW11(1), FZD1(1), FZD10(3), FZD9(1), GSK3B(1), LRP6(2), MAP3K7(3), MMP7(2), NFATC2(2), NFATC4(2), NKD1(1), PLCB1(1), PLCB2(3), PLCB4(1), PORCN(3), PPP2R1B(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), PSEN1(1), ROCK1(2), ROCK2(1), RUVBL1(2), SMAD4(1), SOX17(1), TBL1X(1), TCF7L2(1), VANGL1(1), WIF1(1), WNT1(1), WNT10A(2), WNT11(1), WNT2B(1), WNT3(1), WNT5B(1), WNT8A(1), WNT9A(1), WNT9B(1) 68386594 100 80 100 31 34 14 11 19 22 0 0.145 1.000 1.000 525 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(1), CAPN1(2), CAPN11(2), CAPN6(2), CAPNS1(1), CAV3(1), CSK(1), DOCK1(2), FYN(1), ITGA10(1), ITGA11(1), ITGA2(1), ITGA2B(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), ITGAD(3), ITGAE(1), ITGAM(5), ITGAV(1), ITGAX(6), ITGB1(1), ITGB2(4), ITGB3(1), ITGB4(3), ITGB6(2), ITGB7(3), ITGB8(1), MAP2K1(1), MAP2K3(3), MAPK7(1), PAK1(1), PAK4(2), PIK3R2(3), PXN(1), ROCK1(2), ROCK2(1), SDCCAG8(2), SORBS1(2), SOS1(3), SRC(2), TNS1(3), VASP(1), VAV2(2), VAV3(1), ZYX(2) 57336327 91 79 91 35 36 15 8 23 9 0 0.396 1.000 1.000 526 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 77 AGL(1), AMY2B(3), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), ENPP1(1), EP400(6), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), MOV10L1(4), PGM1(1), PYGB(2), PYGL(1), PYGM(1), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SI(2), SMARCA2(3), SMARCA5(1), TREH(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B7(2), UXS1(2) 51423509 79 70 79 28 32 11 9 21 6 0 0.469 1.000 1.000 527 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 73 CACNA1A(1), GNAO1(1), GRIA1(2), GRIA3(3), GRID2(2), GRM1(3), GRM5(2), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IGF1(2), IGF1R(3), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), LYN(2), MAP2K1(1), MAPK1(2), MAPK3(1), NOS1(5), NOS3(3), NPR1(1), NRAS(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP2R1B(1), PRKCA(1), PRKCG(2), PRKG1(1), PRKG2(5), RAF1(1), RYR1(4) 46566572 81 70 80 38 36 16 5 15 9 0 0.709 1.000 1.000 528 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(1), CARD11(5), CBL(1), CBLB(1), CD28(1), CD3E(2), CD3G(1), CD4(1), CD8A(1), CHUK(1), CSF2(2), FOS(1), FYN(1), GRAP2(1), IFNG(2), IKBKB(1), KRAS(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PAK1(1), PAK4(2), PAK7(1), PDCD1(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PPP3CB(1), PRKCQ(2), PTPN6(1), PTPRC(2), RASGRP1(1), SOS1(3), TEC(1), VAV1(4), VAV2(2), VAV3(1), ZAP70(3) 41672988 87 69 86 30 28 16 11 21 11 0 0.305 1.000 1.000 529 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 75 ABL1(2), ACTN1(2), AKT1(1), ANGPTL2(1), ARHGEF6(2), ARHGEF7(2), CDKN2A(2), CSE1L(1), DOCK1(2), EPHB2(3), FYN(1), GRB7(2), GRLF1(2), ITGA1(2), ITGA10(1), ITGA11(1), ITGA2(1), ITGA3(1), ITGA4(3), ITGA5(1), ITGA7(2), ITGA8(1), ITGA9(2), MAPK1(2), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), MYLK(2), P4HB(1), PAK1(1), PAK4(2), PAK7(1), PIK3CB(4), PKLR(1), PLCG1(6), PLCG2(3), RAF1(1), ROCK1(2), ROCK2(1), SOS1(3), SRC(2), TLN2(2), VASP(1), WAS(1), ZYX(2) 50241553 82 67 82 28 22 13 13 20 14 0 0.346 1.000 1.000 530 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 80 ABL1(2), ATM(4), BUB1(1), CCNA1(1), CCNA2(1), CCNB3(2), CCND2(2), CCND3(1), CCNE1(1), CCNE2(1), CDAN1(2), CDKN1A(1), CDKN2A(2), CHEK1(3), DTX4(2), E2F4(1), E2F6(1), EP300(1), ESPL1(3), GSK3B(1), HDAC2(3), HDAC4(1), HDAC6(1), MAD1L1(1), MCM2(1), MCM3(2), MCM4(2), MCM5(2), MCM6(3), MCM7(2), MDM2(2), MPEG1(1), MPL(3), ORC3L(1), ORC5L(1), PRKDC(3), PTPRA(3), RBL1(2), SKP2(1), SMAD4(1), TBC1D8(3), TFDP1(1), WEE1(1) 46008277 74 66 74 20 17 15 5 25 12 0 0.181 1.000 1.000 531 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 66 ADCY1(3), ADCY8(2), CACNA1C(5), CALM1(1), CAMK2A(1), CAMK4(1), CREBBP(4), EP300(1), GRIA1(2), GRIN2A(10), GRIN2B(3), GRIN2C(2), GRIN2D(1), GRM1(3), GRM5(2), ITPR1(5), ITPR2(3), ITPR3(5), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), PLCB1(1), PLCB2(3), PLCB4(1), PPP1CC(1), PPP3CB(1), PRKCA(1), PRKCG(2), PRKX(1), RAF1(1), RAPGEF3(1), RPS6KA1(1), RPS6KA2(2), RPS6KA3(1), RPS6KA6(2) 42060018 80 66 79 27 39 14 7 14 6 0 0.145 1.000 1.000 532 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 42 ABCA1(1), ABCA10(4), ABCA12(1), ABCA13(5), ABCA3(1), ABCA4(4), ABCA5(3), ABCA6(3), ABCA7(2), ABCA9(3), ABCB11(2), ABCB4(6), ABCB5(3), ABCB6(1), ABCB7(1), ABCB8(1), ABCB9(2), ABCC1(1), ABCC10(2), ABCC11(1), ABCC3(1), ABCC4(4), ABCC5(3), ABCC6(1), ABCC8(1), ABCD1(1), ABCD2(4), ABCD3(1), ABCG1(2), ABCG2(2), ABCG4(1), ABCG5(1), ABCG8(1), CFTR(2), TAP1(1), TAP2(4) 48161734 77 65 76 32 28 13 9 20 7 0 0.536 1.000 1.000 533 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 74 ACTN1(2), ACTN3(1), ACVR1C(2), CREBBP(4), CSNK2B(2), CTNNA1(2), CTNNA2(2), CTNNA3(2), EP300(1), ERBB2(1), FGFR1(1), FYN(1), IGF1R(3), INSR(2), LMO7(2), MAP3K7(3), MAPK1(2), MAPK3(1), MET(3), MLLT4(3), PARD3(1), PTPN6(1), PTPRB(3), PTPRF(5), PTPRJ(1), PTPRM(3), PVRL1(2), PVRL2(1), PVRL4(3), SMAD4(1), SNAI2(2), SORBS1(2), SRC(2), TCF7L2(1), TGFBR1(2), TGFBR2(2), TJP1(3), WAS(1), WASF3(1) 49773531 77 65 77 29 19 15 11 19 13 0 0.500 1.000 1.000 534 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(3), ADCY2(3), ADCY3(3), ADCY4(1), ADCY5(6), ADCY6(2), ADCY7(1), ADCY8(2), AK1(1), AK5(1), ALLC(4), AMPD1(3), AMPD2(1), AMPD3(1), ATP5A1(1), ATP5B(1), ATP5I(1), CANT1(1), DCK(1), ENPP1(1), FHIT(1), GDA(1), GUCY1A3(1), GUCY1B3(1), GUCY2C(1), GUCY2D(1), GUCY2F(1), IMPDH1(2), NPR1(1), NT5E(2), NUDT2(1), PDE1A(2), PDE4A(2), PDE4B(1), PDE6B(2), PDE8A(1), PFAS(1), PKLR(1), POLD1(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(2), PRPS1L1(2), PRPS2(2), RRM2(1) 54769909 77 65 77 25 32 13 5 17 10 0 0.254 1.000 1.000 535 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 96 AKT1(1), CCL3(1), CD86(2), CHUK(1), FOS(1), IFNA10(2), IFNA21(1), IFNAR2(1), IFNB1(1), IKBKB(1), IL12B(2), IL1B(1), IL6(1), IRAK1(2), IRF5(1), LBP(3), LY96(2), MAP2K1(1), MAP2K3(3), MAP3K7(3), MAPK1(2), MAPK13(1), MAPK3(1), NFKB1(1), NFKB2(1), NFKBIA(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), RIPK1(1), STAT1(2), TLR1(2), TLR2(4), TLR3(1), TLR5(2), TLR6(5), TLR7(4), TLR8(1), TLR9(2) 36573945 80 64 80 29 30 17 6 16 11 0 0.268 1.000 1.000 536 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 80 ABL1(2), ABL2(2), AKT1(1), AREG(1), CAMK2A(1), CBL(1), CBLB(1), CDKN1A(1), CDKN1B(1), CRKL(1), EGF(3), ELK1(2), ERBB2(1), GSK3B(1), KRAS(2), MAP2K1(1), MAPK1(2), MAPK3(1), NRAS(1), NRG1(2), NRG4(1), PAK1(1), PAK4(2), PAK7(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG1(6), PLCG2(3), PRKCA(1), PRKCG(2), RAF1(1), SHC4(1), SOS1(3), SRC(2) 40529884 70 62 69 25 19 14 9 22 6 0 0.441 1.000 1.000 537 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 60 AKT1(1), BTK(1), CARD11(5), CD19(1), CD22(6), CHUK(1), CR2(4), FOS(1), GSK3B(1), IFITM1(1), IKBKB(1), INPP5D(3), KRAS(2), LILRB3(1), LYN(2), MALT1(2), NFATC2(2), NFATC4(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NRAS(1), PIK3CB(4), PIK3CG(7), PIK3R2(3), PIK3R3(1), PIK3R5(3), PLCG2(3), PPP3CB(1), PTPN6(1), VAV1(4), VAV2(2), VAV3(1) 30152833 73 61 72 31 27 17 4 17 8 0 0.526 1.000 1.000 538 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 55 CARM1(1), DOT1L(1), EHMT2(2), EZH2(3), HCFC1(1), JMJD4(1), JMJD6(1), KDM6A(3), MEN1(3), MLL(3), MLL2(5), MLL3(10), MLL4(5), MLL5(1), NSD1(1), OGT(1), PPP1CC(1), PRDM7(1), PRDM9(10), PRMT8(1), RBBP5(2), SETD1A(3), SETD2(3), SETDB1(1), SMYD3(2), SUV39H2(1), SUV420H1(1), SUZ12(1) 51005383 69 60 69 23 13 13 7 27 9 0 0.603 1.000 1.000 539 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 ALG1(1), ALG10B(1), ALG3(2), B3GNT7(1), B4GALT2(1), CHST1(1), CHST13(1), CHST2(2), CHST4(1), CHST6(2), CHSY1(2), EXT2(1), EXTL1(1), FUT8(1), GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), HS3ST1(2), HS3ST3A1(2), MAN1A1(1), MGAT2(1), MGAT5(1), MGAT5B(1), NDST3(1), NDST4(6), OGT(1), ST3GAL1(1), ST6GAL1(1), UST(1), WBSCR17(6), XYLT1(1), XYLT2(2) 46948191 66 59 66 25 30 10 8 10 8 0 0.356 1.000 1.000 540 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(7), ACSL1(1), ACSL3(1), ACSL4(1), ACSL6(1), AKT1(1), CAMKK1(1), CD36(1), CHUK(1), CPT1A(1), CPT1C(1), CPT2(1), G6PC(1), IKBKB(1), IRS1(4), IRS4(2), JAK1(2), JAK2(1), JAK3(2), LEPR(1), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), PCK1(3), PPARA(1), PRKAG2(1), PRKAG3(1), PRKCQ(2), PTPN11(4), RXRA(3), SLC2A1(2), STAT3(1), TNFRSF1A(1), TNFRSF1B(1), TYK2(3) 35384183 60 57 60 22 22 10 3 16 9 0 0.410 1.000 1.000 541 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(1), COL2A1(2), CPSF1(4), CSTF1(1), CSTF2(1), DDIT3(1), DDX20(1), DHX38(1), DHX8(1), DICER1(5), FUS(1), LOC440563(2), NCBP2(1), NONO(2), NUDT21(1), NXF1(1), PABPN1(1), PAPOLA(2), PHF5A(1), POLR2A(2), PRPF4(1), PRPF4B(1), PRPF8(2), PTBP1(1), SF3A1(2), SF3A2(1), SF3A3(1), SF3B1(1), SF3B2(1), SF3B4(1), SFRS16(1), SFRS2(1), SFRS5(2), SFRS8(1), SNRPB(1), SRPK1(2), SRPK2(1), SRRM1(1) 45065784 54 51 54 12 17 7 8 10 12 0 0.134 1.000 1.000 542 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 44 AKT1(1), BCL2(2), BTK(1), CD19(1), CD22(6), CR2(4), CSK(1), DAG1(2), FLOT1(1), GSK3B(1), INPP5D(3), ITPR1(5), ITPR2(3), ITPR3(5), LYN(2), MAP4K1(2), MAPK1(2), MAPK3(1), NFATC2(2), NR0B2(1), PLCG2(3), PPP3CB(1), PTPRC(2), RAF1(1), SOS1(3), VAV1(4) 30000344 60 51 60 21 23 12 6 9 10 0 0.258 1.000 1.000 543 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(3), ADCY4(1), ADCY6(2), ADCY8(2), CACNA1A(1), CACNA1B(6), GNAT3(4), GNB1(1), GRM4(2), ITPR3(5), KCNB1(2), PDE1A(2), PLCB2(3), PRKX(1), SCNN1A(1), SCNN1B(3), SCNN1G(4), TAS1R1(2), TAS1R2(2), TAS2R1(2), TAS2R10(1), TAS2R16(1), TAS2R39(1), TAS2R41(2), TAS2R5(1), TAS2R60(1), TRPM5(1) 24513275 57 50 56 25 28 7 6 8 8 0 0.613 1.000 1.000 544 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 CCR3(1), CCR5(1), CELSR1(4), CELSR2(2), CELSR3(5), CHRM2(3), CHRM3(1), EMR2(1), EMR3(1), FSHR(1), GHRHR(1), GNRHR(1), GPR116(6), GPR132(2), GPR133(3), GPR143(2), GPR17(1), GPR61(1), GPR77(1), GRM1(3), GRPR(1), LGR6(1), LPHN2(1), LPHN3(2), NTSR1(3), OR2M4(2), OR8G2(1), PTGFR(1), SMO(1), SSTR2(1), TSHR(1) 28459266 56 49 56 37 31 4 5 14 2 0 0.978 1.000 1.000 545 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 45 INPP1(1), INPP4B(1), INPP5A(1), INPP5B(1), INPP5E(1), INPPL1(3), ITGB1BP3(1), MIOX(1), OCRL(2), PI4KA(1), PI4KB(2), PIK3CB(4), PIK3CG(7), PIP4K2C(3), PIP5K1B(2), PIP5K1C(1), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCE1(2), PLCG1(6), PLCG2(3), PLCZ1(1), SYNJ2(3) 30401593 55 44 55 19 19 7 5 16 8 0 0.430 1.000 1.000 546 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 BTK(1), CAD(3), CASP10(1), CASP8AP2(1), CD7(2), DAXX(3), DEDD(1), DEDD2(1), EPHB2(3), FAF1(1), IL1A(1), MAP3K1(6), MAP3K5(1), MAPK1(2), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(3), MET(3), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), NR0B2(1), PTPN13(1), RALBP1(1), RIPK1(1), ROCK1(2), TPX2(2) 29800546 51 43 49 17 14 14 12 7 4 0 0.281 1.000 1.000 547 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 41 AKT1(1), ANGPTL2(1), ARHGAP4(2), ARHGEF11(2), BTK(1), CFL2(1), GDI1(1), INPPL1(3), ITPR1(5), ITPR2(3), ITPR3(5), MYLK(2), PAK1(1), PAK4(2), PAK7(1), PIK3CG(7), PITX2(3), ROCK1(2), ROCK2(1), RPS4X(1) 28115546 45 39 45 16 20 12 2 2 9 0 0.263 1.000 1.000 548 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), HK2(2), HK3(2), LDHAL6A(1), LDHAL6B(1), PDHA1(1), PDHA2(3), PFKL(1), PGAM4(1), PGK1(1), PGK2(1), PGM1(1), PKLR(1) 24734126 41 38 41 17 17 6 2 13 3 0 0.561 1.000 1.000 549 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(2), CAD(3), CANT1(1), CDA(2), CTPS(1), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NME7(2), NT5C1B(2), NT5E(2), NUDT2(1), PNPT1(1), POLA1(1), POLA2(1), POLD1(1), POLD4(1), POLE2(1), POLR1A(2), POLR1B(1), POLR2A(2), POLR2B(1), POLR3B(1), POLR3G(1), PRIM1(1), PRIM2(1), RRM2(1), TXNRD1(1), TXNRD2(2), UCK1(1), UPP1(2), UPP2(1) 34619747 45 38 45 14 10 12 9 11 3 0 0.257 1.000 1.000 550 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(1), ALPP(2), ALPPL2(4), ASCC3(4), ATP13A2(2), DDX18(1), DDX41(3), DDX56(1), DHX58(1), EP400(6), MOV10L1(4), RAD54B(2), RAD54L(1), RUVBL2(2), SETX(1), SMARCA2(3), SMARCA5(1) 26755541 39 37 39 13 14 8 4 10 3 0 0.383 1.000 1.000 551 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(1), CANX(1), CD4(1), CD8A(1), CIITA(3), CREB1(1), CTSB(1), CTSS(1), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(1), HLA-DRA(1), HLA-F(1), HSP90AB1(2), IFNA10(2), IFNA21(1), KIR2DL1(2), KIR2DL3(1), KIR2DL4(1), KIR2DS4(1), KIR3DL1(3), KLRC1(1), KLRC3(4), KLRD1(1), NFYB(1), PDIA3(1), RFX5(1), TAP1(1), TAP2(4) 19797348 42 37 42 21 17 7 5 8 5 0 0.842 1.000 1.000 552 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PGK1(1), PGM1(1), PKLR(1) 20727978 38 35 38 16 18 7 1 10 2 0 0.544 1.000 1.000 553 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(2), ADH1C(2), AKR1A1(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), ALDH3B2(1), ALDOB(1), BPGM(2), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), HK2(2), HK3(2), PDHA1(1), PDHA2(3), PGK1(1), PGM1(1), PKLR(1) 20727978 38 35 38 16 18 7 1 10 2 0 0.544 1.000 1.000 554 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(1), ALOX5(1), CBR1(2), CYP2B6(4), CYP2C18(1), CYP2C19(1), CYP2C8(2), CYP2E1(1), CYP2U1(1), CYP4A11(4), CYP4F2(3), CYP4F3(2), GGT1(1), GPX1(1), GPX4(1), GPX5(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PTGIS(2), PTGS1(1), PTGS2(1), TBXAS1(1) 16584477 38 33 38 14 19 5 1 10 3 0 0.365 1.000 1.000 555 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 21 INPP1(1), INPP4B(1), INPP5A(1), INPPL1(3), MIOX(1), OCRL(2), PIK3C2A(1), PIK3C2B(1), PIK3CB(4), PIK3CG(7), PLCB1(1), PLCB2(3), PLCB4(1), PLCD1(3), PLCG1(6), PLCG2(3) 17094147 39 32 39 15 12 6 2 12 7 0 0.701 1.000 1.000 556 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOB(1), DLD(2), ENO2(1), ENO3(1), FBP1(2), FBP2(1), G6PC(1), GAPDH(1), GAPDHS(1), GOT2(1), HK2(2), HK3(2), LDHAL6B(1), PC(2), PCK1(3), PDHA1(1), PDHA2(3), PFKL(1), PGK1(1), PGK2(1), PKLR(1), TNFAIP1(1) 18024623 31 31 31 16 13 5 1 10 2 0 0.781 1.000 1.000 557 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALNT1(2), B3GALT5(1), B3GNT3(2), B4GALNT1(1), B4GALT2(1), B4GALT6(1), FUT3(2), FUT4(1), FUT5(3), FUT6(1), FUT7(1), GBGT1(1), GCNT2(1), PIGF(1), PIGN(1), PIGO(2), PIGU(1), PIGZ(1), ST3GAL1(1), ST3GAL6(2), ST6GALNAC3(1), ST6GALNAC4(1), ST8SIA1(1) 20709753 31 31 31 12 10 3 3 11 4 0 0.703 1.000 1.000 558 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 37 AKT1(1), BTK(1), CD19(1), CSK(1), DAG1(2), EPHB2(3), LYN(2), MAP2K1(1), MAPK1(2), NFKB1(1), NFKB2(1), NFKBIA(1), NFKBIE(2), NFKBIL2(2), PLCG2(3), RAF1(1), SOS1(3), VAV1(4) 20832329 32 31 32 14 5 11 6 6 4 0 0.652 1.000 1.000 559 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 40 AGL(1), AMY2B(3), ENPP1(1), G6PC(1), GAA(1), HK2(2), HK3(2), MGAM(6), PGM1(1), PYGB(2), PYGL(1), PYGM(1), SI(2), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1), UXS1(2) 23876964 34 31 34 16 19 3 2 7 3 0 0.768 1.000 1.000 560 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(1), DLD(2), DUSP10(1), IL1R1(2), MAP3K1(6), MAP3K12(1), MAP3K13(1), MAP3K4(3), MAP3K5(1), MAP3K7(3), MAP3K9(3), MAPK7(1), NR2C2(1), PAPPA(2), ZAK(3) 21102017 31 30 29 12 7 13 5 5 1 0 0.491 1.000 1.000 561 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP4A(1), ATP5A1(1), ATP5B(1), ATP5I(1), ATP6AP1(1), ATP6V0A4(3), ATP6V0D1(2), ATP6V0D2(1), ATP6V1A(1), ATP6V1C1(2), ATP6V1C2(1), ATP6V1G1(1), COX10(2), COX7C(1), LHPP(1), NDUFA10(1), NDUFA12(1), NDUFA13(1), NDUFA4(1), NDUFA9(1), NDUFB1(1), NDUFS2(1), PPA2(1), UQCRC1(1), UQCRQ(1) 23808656 30 28 30 11 11 5 4 8 2 0 0.512 1.000 1.000 562 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(3), CANT1(1), CDA(2), CTPS(1), DCK(1), DPYD(2), DPYS(1), DTYMK(1), NT5E(2), NUDT2(1), POLD1(1), POLL(1), POLQ(3), POLR1B(1), POLR2A(2), POLR2B(1), POLRMT(2), RRM2(1), TXNRD1(1), UCK1(1), UPP1(2) 24465057 31 28 31 12 3 6 6 12 4 0 0.748 1.000 1.000 563 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), INS(1), INSR(2), IRS1(4), JAK2(1), MAP2K1(1), MAPK1(2), MAPK3(1), PLCG1(6), PRKCA(1), PTPN6(1), RAF1(1), RPS6KA1(1), SOCS1(1), SOS1(3), SRF(1) 12443750 28 27 28 10 7 5 5 7 4 0 0.537 1.000 1.000 564 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 GALNT1(1), GALNT11(1), GALNT13(2), GALNT14(3), GALNT2(1), GALNT5(2), GALNT6(1), GALNT7(1), GALNT9(2), GALNTL1(1), GALNTL4(1), GCNT1(2), GCNT3(1), GCNT4(1), OGT(1), ST3GAL1(1), WBSCR17(6) 13697206 28 27 28 10 13 4 1 5 5 0 0.553 1.000 1.000 565 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(4), GRM1(3), GRM3(9), GRM4(2), GRM5(2), GRM7(2), GRM8(5) 8891338 27 25 26 22 20 0 1 6 0 0 0.978 1.000 1.000 566 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 28 AKT1(1), CABIN1(5), CALM1(1), CAMK1(1), IGF1(2), IGF1R(3), INS(1), INSR(2), MAPK7(1), MEF2A(2), MEF2D(1), MYOD1(1), NFATC2(2), PPP3CB(1), SYT1(1), YWHAH(1) 13246561 26 25 26 11 6 4 5 7 4 0 0.566 1.000 1.000 567 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(2), AADAC(1), ACADS(3), ACSM1(1), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), ALDH5A1(1), ECHS1(1), EHHADH(1), GAD1(1), HADHA(1), HSD17B4(1), OXCT2(1), PDHA1(1), PDHA2(3), PLA1A(1), PPME1(1) 17297037 24 24 24 10 9 5 2 4 4 0 0.597 1.000 1.000 568 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSE(3), ASAH1(1), B4GALT6(1), ENPP7(4), GAL3ST1(2), LCT(3), NEU1(1), NEU2(3), NEU4(2), SGMS2(1), SGPP2(2), UGT8(1) 15338876 24 23 24 12 10 6 2 5 1 0 0.636 1.000 1.000 569 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(1), C6(1), ICAM1(1), IL1A(1), IL6(1), ITGA4(3), ITGB1(1), ITGB2(4), SELP(2), SELPLG(2), VCAM1(1) 10566078 24 23 24 14 6 3 3 7 5 0 0.899 1.000 1.000 570 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ARHGAP4(2), ARHGAP5(3), ARHGAP6(2), ARHGEF11(2), ARHGEF5(2), ARPC2(1), GSN(1), MYLK(2), OPHN1(2), PIP5K1B(2), PPP1R12B(1), ROCK1(2), SRC(2) 19525115 24 23 23 11 5 5 3 7 4 0 0.792 1.000 1.000 571 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 B4GALT2(1), FBP2(1), G6PC(1), GAA(1), GALE(2), GALK1(1), GALK2(1), GALT(1), HK2(2), HK3(2), LCT(3), MGAM(6), PGM1(1) 13915704 23 22 23 10 11 4 2 4 2 0 0.558 1.000 1.000 572 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 22 RPE(1), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2A1(4), UGT2B10(4), UGT2B11(2), UGT2B15(1), UGT2B7(2), XYLB(1) 10216962 22 22 22 11 8 3 4 6 1 0 0.808 1.000 1.000 573 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASS(1), AKR1B10(1), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1), HSD17B4(1), NSD1(1), OGDHL(3), PIPOX(1), SETD1A(3), SETDB1(1), SUV39H2(1) 24788030 22 22 22 14 9 5 0 6 2 0 0.942 1.000 1.000 574 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 29 AKR1C4(2), ARSE(3), CYP11B1(1), CYP11B2(2), HSD11B1(2), HSD17B3(1), SRD5A1(1), SRD5A2(1), STS(2), UGT1A10(1), UGT1A5(1), UGT1A6(2), UGT1A7(1), UGT1A9(2), UGT2B15(1) 11183016 23 21 23 11 9 6 1 5 2 0 0.626 1.000 1.000 575 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 19 ADCYAP1R1(1), CALCRL(1), CD97(1), CRHR2(2), ELTD1(5), EMR1(1), EMR2(1), GHRHR(1), GLP1R(1), GLP2R(2), GPR64(1), LPHN1(1), LPHN2(1), LPHN3(2), VIPR2(1) 11060580 22 20 22 10 8 0 3 9 2 0 0.759 1.000 1.000 576 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(3), ICAM1(1), ITGA4(3), ITGAM(5), ITGB1(1), ITGB2(4), SELE(2), SELP(2) 6811851 21 20 21 15 9 1 3 5 3 0 0.921 1.000 1.000 577 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 17 CBL(1), EGF(3), MAP2K1(1), MAPK1(2), MAPK3(1), PTPRB(3), RAF1(1), SOS1(3), SPRY3(2), SRC(2) 9483318 19 19 19 11 3 2 3 9 2 0 0.941 1.000 1.000 578 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(1), LRP8(1), RELN(13) 5950091 18 18 18 10 6 2 4 2 4 0 0.729 1.000 1.000 579 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B10(1), ALDOB(1), FBP1(2), FBP2(1), HK2(2), HK3(2), LHPP(1), MTMR1(2), PFKFB1(2), PFKFB4(1), PFKL(1), PMM1(1) 15893761 17 16 17 12 11 1 2 2 1 0 0.916 1.000 1.000 580 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(1), AGPAT6(1), ENPP2(4), ENPP6(1), PLA2G2F(1), PLA2G3(1), PLA2G4A(3), PLA2G6(1), PLD1(1) 9880343 16 16 16 7 9 2 0 5 0 0 0.682 1.000 1.000 581 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PFKL(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1), TKTL1(1), TKTL2(1) 10352264 15 15 15 9 8 2 2 3 0 0 0.815 1.000 1.000 582 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSE(3), ASAH1(1), GAL3ST1(2), LCT(3), NEU1(1), NEU2(3), NEU4(2) 10365168 15 14 15 10 6 3 1 4 1 0 0.887 1.000 1.000 583 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(4), BST1(1), CD38(1), ENPP1(1), NADSYN1(1), NNT(1), NT5C1B(2), NT5E(2), NUDT12(1) 9152517 14 14 13 9 5 3 3 3 0 0 0.843 1.000 1.000 584 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(3), ICAM1(1), ITGA4(3), ITGB1(1), ITGB2(4), SELE(2) 5171941 14 14 14 11 5 1 2 3 3 0 0.928 1.000 1.000 585 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(3), ICAM1(1), ITGAM(5), ITGB2(4), SELE(2) 4461475 15 14 15 12 7 0 2 3 3 0 0.938 1.000 1.000 586 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 HGSNAT(1), HPSE(3), HPSE2(2), LCT(3), SPAM1(4) 8756292 13 13 12 7 6 3 0 4 0 0 0.790 1.000 1.000 587 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASS(1), ALDH1A1(1), ALDH1A2(2), ALDH1A3(1), ALDH3A1(2), DOT1L(1), ECHS1(1), EHHADH(1), EHMT2(2), HADHA(1) 15800659 13 13 13 11 8 3 0 1 1 0 0.959 1.000 1.000 588 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), PGK1(1), PGK2(1), PKLR(1), RPE(1), TKTL1(1), TKTL2(1) 8542740 12 12 12 10 5 2 0 5 0 0 0.972 1.000 1.000 589 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOB(1), FBP1(2), FBP2(1), G6PD(1), PGLS(1), PGM1(1), PRPS1L1(2), PRPS2(2), RPE(1) 8685122 12 12 12 8 5 2 2 3 0 0 0.882 1.000 1.000 590 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOB(1), FBP1(2), FBP2(1), GOT2(1), ME1(1), ME2(1), PGK1(1), PKLR(1), RPE(1) 7645487 10 10 10 8 3 2 0 5 0 0 0.964 1.000 1.000 591 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 FOS(1), FOSL2(1), IFNAR2(1), IFNB1(1), NFKB1(1), TNFRSF11A(2), TNFSF11(1) 4722990 8 8 8 5 3 3 0 2 0 0 0.834 1.000 1.000 592 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALNT1(2), B3GALT5(1), GBGT1(1), ST3GAL1(1), ST8SIA1(1) 4560397 6 6 6 6 1 0 0 5 0 0 0.992 1.000 1.000 593 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CD36(1), FOS(1), FYN(1), THBS1(2) 3125230 5 5 5 4 2 1 1 1 0 0 0.869 1.000 1.000 594 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGEF2(3), KDELR1(1) 6871795 4 4 4 4 1 2 0 1 0 0 0.939 1.000 1.000 595 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(1), PFKL(1), PGK1(1), PKLR(1) 3943946 4 4 4 3 2 0 0 2 0 0 0.904 1.000 1.000 596 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT5(1), FUT3(2) 3062162 4 4 4 3 3 0 0 1 0 0 0.869 1.000 1.000 597 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 6 EGF(3) 4322532 3 3 3 4 0 0 0 3 0 0 0.993 1.000 1.000 598 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(1), GPD2(1), UQCRC1(1) 2803186 3 3 3 3 0 1 1 1 0 0 0.927 1.000 1.000 599 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 GBGT1(1), ST3GAL1(1), ST8SIA1(1) 4298312 3 3 3 6 1 0 0 2 0 0 0.999 1.000 1.000 600 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 LCT(3) 6135585 3 3 3 6 1 1 0 1 0 0 0.996 1.000 1.000 601 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(1), PON1(2) 3832924 3 3 3 5 1 0 0 2 0 0 0.997 1.000 1.000 602 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASS(1), KARS(2) 2948262 3 3 3 3 2 0 0 1 0 0 0.965 1.000 1.000 603 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(1), PRKAR2B(1) 4277470 2 2 2 2 0 0 0 2 0 0 0.955 1.000 1.000 604 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 NDUFA12(1), NDUFA13(1) 1725322 2 2 2 2 2 0 0 0 0 0 0.900 1.000 1.000 605 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 ESCO1(1), MYST4(1) 7032636 2 2 2 2 0 2 0 0 0 0 0.893 1.000 1.000 606 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(1) 2054840 1 1 1 2 1 0 0 0 0 0 0.981 1.000 1.000 607 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 SUCLA2(1) 3977034 1 1 1 3 0 1 0 0 0 0 0.988 1.000 1.000 608 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 P2RY2(1) 2526610 1 1 1 2 1 0 0 0 0 0 0.945 1.000 1.000 609 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR2(1) 2661386 1 1 1 2 0 0 1 0 0 0 0.985 1.000 1.000 610 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 214514 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 611 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 948253 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 612 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 1319270 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 613 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 647612 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 614 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 722306 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000 615 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 1820179 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 1430860 0 0 0 0 0 0 0 0 0 0 1.000 1.000 1.000