E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.05 0.182 -9999.0 0.0 -0.46 24.0 24.0 KLHL20 -0.03 0.059 -9999.0 0.0 -0.232 4.0 4.0 CYFIP2 0.009 0.048 -9999.0 0.0 -0.587 1.0 1.0 Rac1/GDP -0.008 0.125 -9999.0 0.0 -0.396 2.0 2.0 ENAH -0.05 0.182 -9999.0 0.0 -0.46 24.0 24.0 AP1M1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.006 0.057 -9999.0 0.0 -0.49 2.0 2.0 RAP1A 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.041 0.078 -9999.0 0.0 -0.394 1.0 1.0 ABI1/Sra1/Nap1 -0.02 0.041 -9999.0 0.0 -0.176 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.05 0.152 -9999.0 0.0 -0.335 27.0 27.0 RAPGEF1 -0.032 0.166 -9999.0 0.0 -0.4 24.0 24.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.059 0.186 -9999.0 0.0 -0.479 24.0 24.0 CRK -0.041 0.173 -9999.0 0.0 -0.427 24.0 24.0 E-cadherin/gamma catenin/alpha catenin -0.058 0.161 -9999.0 0.0 -0.352 34.0 34.0 alphaE/beta7 Integrin 0.003 0.079 -9999.0 0.0 -0.384 6.0 6.0 IQGAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.021 0.032 -9999.0 0.0 -0.255 2.0 2.0 DLG1 -0.05 0.182 -9999.0 0.0 -0.46 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.031 0.056 -9999.0 0.0 -0.268 1.0 1.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.023 0.023 -9999.0 0.0 -0.255 1.0 1.0 PI3K -0.039 0.072 -9999.0 0.0 -0.355 1.0 1.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.078 0.187 -9999.0 0.0 -0.42 34.0 34.0 TIAM1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ -0.037 0.128 -9999.0 0.0 -0.298 24.0 24.0 AKT1 -0.023 0.042 -9999.0 0.0 -0.192 1.0 1.0 PIK3R1 0.006 0.063 -9999.0 0.0 -0.539 2.0 2.0 CDH1 -0.111 0.237 -9999.0 0.0 -0.561 33.0 33.0 RhoA/GDP -0.008 0.125 -9999.0 0.0 -0.396 2.0 2.0 actin cytoskeleton organization 0.01 0.062 -9999.0 0.0 -0.176 3.0 3.0 CDC42/GDP -0.008 0.125 -9999.0 0.0 -0.396 2.0 2.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.034 0.114 -9999.0 0.0 -0.275 25.0 25.0 ITGB7 -0.002 0.092 -9999.0 0.0 -0.563 4.0 4.0 RAC1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.039 0.137 -9999.0 0.0 -0.316 24.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.044 0.128 -9999.0 0.0 -0.287 33.0 33.0 mol:GDP -0.02 0.143 -9999.0 0.0 -0.325 24.0 24.0 CDC42/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.002 0.074 -9999.0 0.0 -0.522 3.0 3.0 p120 catenin/RhoA/GDP -0.051 0.105 -9999.0 0.0 -0.401 2.0 2.0 RAC1/GTP/IQGAP1 0.018 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.016 0.036 -9999.0 0.0 -0.425 1.0 1.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.008 0.051 -9999.0 0.0 -0.182 4.0 4.0 NME1 0.01 0.041 -9999.0 0.0 -0.49 1.0 1.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.05 0.182 -9999.0 0.0 -0.46 24.0 24.0 regulation of cell-cell adhesion -0.036 0.069 -9999.0 0.0 -0.34 1.0 1.0 WASF2 -0.01 0.021 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.047 0.09 -9999.0 0.0 -0.459 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.046 0.152 -9999.0 0.0 -0.537 4.0 4.0 CCND1 0.009 0.061 -9999.0 0.0 -0.225 4.0 4.0 VAV2 -0.048 0.202 -9999.0 0.0 -0.465 26.0 26.0 RAP1/GDP -0.008 0.117 -9999.0 0.0 -0.496 1.0 1.0 adherens junction assembly -0.047 0.176 -9999.0 0.0 -0.445 24.0 24.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.009 0.048 -9999.0 0.0 -0.587 1.0 1.0 regulation of heterotypic cell-cell adhesion -0.037 0.147 -9999.0 0.0 -0.512 4.0 4.0 E-cadherin/beta catenin -0.073 0.143 -9999.0 0.0 -0.33 34.0 34.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.052 0.182 -9999.0 0.0 -0.46 24.0 24.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.048 0.094 -9999.0 0.0 -0.383 4.0 4.0 E-cadherin/beta catenin/alpha catenin -0.052 0.149 -9999.0 0.0 -0.335 33.0 33.0 ITGAE 0.006 0.057 -9999.0 0.0 -0.49 2.0 2.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.086 0.178 -9999.0 0.0 -0.49 24.0 24.0