Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.027 0.208 -9999.0 0.0 -0.664 11.0 11.0 IHH -0.012 0.096 -9999.0 0.0 -0.457 5.0 5.0 SHH Np/Cholesterol/GAS1 -0.102 0.172 -9999.0 0.0 -0.316 56.0 56.0 LRPAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.102 0.171 0.314 56.0 -9999.0 0.0 56.0 SMO/beta Arrestin2 -0.018 0.142 -9999.0 0.0 -0.69 3.0 3.0 SMO -0.025 0.149 -9999.0 0.0 -0.733 3.0 3.0 AKT1 0.005 0.081 -9999.0 0.0 -0.53 1.0 1.0 ARRB2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.002 0.074 -9999.0 0.0 -0.522 3.0 3.0 ADRBK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.025 0.147 -9999.0 0.0 -0.637 4.0 4.0 STIL -0.076 0.175 -9999.0 0.0 -0.604 6.0 6.0 DHH N/PTCH2 -0.03 0.138 -9999.0 0.0 -0.4 18.0 18.0 DHH N/PTCH1 -0.038 0.172 -9999.0 0.0 -0.479 13.0 13.0 PIK3CA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.037 0.156 -9999.0 0.0 -0.525 14.0 14.0 PTHLH -0.027 0.222 -9999.0 0.0 -0.714 11.0 11.0 determination of left/right symmetry -0.025 0.147 -9999.0 0.0 -0.637 4.0 4.0 PIK3R1 0.006 0.063 -9999.0 0.0 -0.539 2.0 2.0 skeletal system development -0.026 0.22 -9999.0 0.0 -0.706 11.0 11.0 IHH N/Hhip -0.101 0.204 -9999.0 0.0 -0.435 40.0 40.0 DHH N/Hhip -0.113 0.209 -9999.0 0.0 -0.419 46.0 46.0 mol:Cholesterol 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.025 0.147 -9999.0 0.0 -0.637 4.0 4.0 pancreas development -0.121 0.239 -9999.0 0.0 -0.542 37.0 37.0 HHAT -0.006 0.103 -9999.0 0.0 -0.568 5.0 5.0 PI3K 0.014 0.046 -9999.0 0.0 -0.384 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.046 0.166 -9999.0 0.0 -0.513 17.0 17.0 somite specification -0.025 0.147 -9999.0 0.0 -0.637 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.087 0.184 -9999.0 0.0 -0.525 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.081 0.159 -9999.0 0.0 -0.304 48.0 48.0 SHH Np/Cholesterol/Megalin -0.177 0.217 -9999.0 0.0 -0.367 78.0 78.0 SHH -0.101 0.187 -9999.0 0.0 -0.385 45.0 45.0 catabolic process -0.019 0.162 -9999.0 0.0 -0.512 10.0 10.0 SMO/Vitamin D3 -0.076 0.183 -9999.0 0.0 -0.657 6.0 6.0 SHH Np/Cholesterol/Hhip -0.145 0.197 -9999.0 0.0 -0.337 71.0 71.0 LRP2 -0.179 0.269 -9999.0 0.0 -0.552 52.0 52.0 receptor-mediated endocytosis -0.142 0.211 -9999.0 0.0 -0.509 26.0 26.0 SHH Np/Cholesterol/BOC -0.077 0.147 -9999.0 0.0 -0.289 48.0 48.0 SHH Np/Cholesterol/CDO -0.083 0.153 -9999.0 0.0 -0.296 50.0 50.0 mesenchymal cell differentiation 0.144 0.195 0.334 71.0 -9999.0 0.0 71.0 mol:Vitamin D3 -0.085 0.185 -9999.0 0.0 -0.525 10.0 10.0 IHH N/PTCH2 -0.009 0.1 -9999.0 0.0 -0.467 5.0 5.0 CDON -0.009 0.107 -9999.0 0.0 -0.539 6.0 6.0 IHH N/PTCH1 -0.018 0.163 -9999.0 0.0 -0.515 10.0 10.0 Megalin/LRPAP1 -0.122 0.198 -9999.0 0.0 -0.395 52.0 52.0 PTCH2 -0.006 0.103 -9999.0 0.0 -0.568 5.0 5.0 SHH Np/Cholesterol -0.085 0.14 -9999.0 0.0 -0.297 45.0 45.0 PTCH1 -0.019 0.162 -9999.0 0.0 -0.514 10.0 10.0 HHIP -0.121 0.239 -9999.0 0.0 -0.543 37.0 37.0