Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.026 0.107 -9999.0 0.0 -0.253 25.0 25.0 epithelial cell differentiation -0.06 0.115 -9999.0 0.0 -0.295 24.0 24.0 CYFIP2 0.009 0.048 -9999.0 0.0 -0.587 1.0 1.0 ENAH 0.008 0.092 -9999.0 0.0 -9999.0 0.0 0.0 EGFR -0.226 0.276 -9999.0 0.0 -0.54 66.0 66.0 EPHA2 -0.001 0.084 -9999.0 0.0 -0.514 4.0 4.0 MYO6 -0.028 0.122 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.024 0.031 -9999.0 0.0 -0.355 1.0 1.0 AQP5 -0.152 0.23 -9999.0 0.0 -0.551 33.0 33.0 CTNND1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.029 0.122 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.039 0.137 -9999.0 0.0 -0.294 28.0 28.0 EGF -0.04 0.167 -9999.0 0.0 -0.566 14.0 14.0 NCKAP1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.069 0.126 -9999.0 0.0 -0.438 9.0 9.0 cortical microtubule organization -0.06 0.115 -9999.0 0.0 -0.295 24.0 24.0 GO:0000145 -0.028 0.117 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.036 0.129 -9999.0 0.0 -0.298 24.0 24.0 MLLT4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.05 0.089 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.023 0.055 -9999.0 0.0 -0.317 2.0 2.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.017 0.116 -9999.0 0.0 -9999.0 0.0 0.0 PVRL2 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.028 0.122 -9999.0 0.0 -0.277 24.0 24.0 ARF6/GTP -0.008 0.045 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.111 0.237 -9999.0 0.0 -0.561 33.0 33.0 EGFR/EGFR/EGF/EGF -0.181 0.178 -9999.0 0.0 -0.541 19.0 19.0 RhoA/GDP -0.055 0.107 -9999.0 0.0 -0.274 24.0 24.0 actin cytoskeleton organization -0.021 0.118 -9999.0 0.0 -9999.0 0.0 0.0 IGF-1R heterotetramer 0.006 0.057 -9999.0 0.0 -0.489 2.0 2.0 GIT1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.006 0.057 -9999.0 0.0 -0.49 2.0 2.0 IGF1 -0.03 0.149 -9999.0 0.0 -0.539 12.0 12.0 DIAPH1 -0.002 0.057 -9999.0 0.0 -0.7 1.0 1.0 Wnt receptor signaling pathway 0.06 0.115 0.295 24.0 -9999.0 0.0 24.0 RHOA 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.051 0.09 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.021 0.12 -9999.0 0.0 -9999.0 0.0 0.0 EFNA1 0.009 0.048 -9999.0 0.0 -0.587 1.0 1.0 LPP -0.023 0.119 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2 -0.06 0.106 -9999.0 0.0 -9999.0 0.0 0.0 SEC6/SEC8 -0.047 0.091 -9999.0 0.0 -9999.0 0.0 0.0 MGAT3 -0.04 0.14 -9999.0 0.0 -0.299 28.0 28.0 HGF/MET -0.169 0.199 -9999.0 0.0 -0.553 23.0 23.0 HGF -0.094 0.223 -9999.0 0.0 -0.554 29.0 29.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.026 0.108 -9999.0 0.0 -0.255 25.0 25.0 actin cable formation 0.025 0.092 -9999.0 0.0 -9999.0 0.0 0.0 KIAA1543 -0.126 0.189 -9999.0 0.0 -0.545 14.0 14.0 KIFC3 -0.03 0.124 -9999.0 0.0 -0.277 25.0 25.0 NCK1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.03 0.124 -9999.0 0.0 -0.277 25.0 25.0 NCK1/GIT1 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP -0.06 0.115 -9999.0 0.0 -0.295 24.0 24.0 EXOC4 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.028 0.122 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C -0.03 0.124 -9999.0 0.0 -9999.0 0.0 0.0 LIMA1 0.009 0.048 -9999.0 0.0 -0.587 1.0 1.0 ABI1 0.013 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.001 0.103 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly -0.104 0.193 -9999.0 0.0 -0.536 14.0 14.0 IGF-1R heterotetramer/IGF1 -0.075 0.131 -9999.0 0.0 -0.507 5.0 5.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.019 0.0 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.141 0.248 -9999.0 0.0 -0.535 43.0 43.0 PLEKHA7 -0.043 0.144 -9999.0 0.0 -0.307 28.0 28.0 mol:GTP 0.022 0.055 -9999.0 0.0 -0.315 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.001 0.11 -9999.0 0.0 -9999.0 0.0 0.0 cortical actin cytoskeleton stabilization -0.026 0.107 -9999.0 0.0 -0.253 25.0 25.0 regulation of cell-cell adhesion -0.021 0.118 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.026 0.108 -9999.0 0.0 -0.255 25.0 25.0