E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.047 0.161 -9999.0 0.0 -0.404 24.0 24.0 KLHL20 0.023 0.098 0.177 12.0 -0.238 3.0 15.0 CYFIP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP -0.017 0.106 0.268 1.0 -0.262 19.0 20.0 ENAH -0.044 0.158 -9999.0 0.0 -0.404 23.0 23.0 AP1M1 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.029 0.009 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.006 0.085 -9999.0 0.0 -0.312 1.0 1.0 ABI1/Sra1/Nap1 -0.02 0.043 -9999.0 0.0 -0.164 3.0 3.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.019 0.115 -9999.0 0.0 -0.228 24.0 24.0 RAPGEF1 -0.038 0.152 0.23 1.0 -0.38 21.0 22.0 CTNND1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.04 0.167 -9999.0 0.0 -0.412 24.0 24.0 CRK -0.042 0.156 -9999.0 0.0 -0.397 21.0 21.0 E-cadherin/gamma catenin/alpha catenin 0.006 0.115 -9999.0 0.0 -0.247 24.0 24.0 alphaE/beta7 Integrin 0.04 0.04 -9999.0 0.0 -0.278 2.0 2.0 IQGAP1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.051 0.024 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.048 0.161 -9999.0 0.0 -0.404 24.0 24.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.035 0.048 -9999.0 0.0 -0.225 1.0 1.0 MLLT4 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.056 0.019 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.044 0.061 -9999.0 0.0 -0.293 1.0 1.0 ARF6 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.014 0.124 -9999.0 0.0 -0.29 24.0 24.0 TIAM1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.021 0.105 -9999.0 0.0 -0.212 23.0 23.0 AKT1 -0.017 0.052 -9999.0 0.0 -0.17 1.0 1.0 PIK3R1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 -0.042 0.157 -9999.0 0.0 -0.403 23.0 23.0 RhoA/GDP -0.011 0.119 0.267 1.0 -0.261 21.0 22.0 actin cytoskeleton organization 0.021 0.076 0.146 12.0 -0.189 2.0 14.0 CDC42/GDP -0.012 0.119 0.267 1.0 -0.261 21.0 22.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.02 0.088 -9999.0 0.0 -0.215 24.0 24.0 ITGB7 0.025 0.051 -9999.0 0.0 -0.403 2.0 2.0 RAC1 0.021 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.023 0.112 -9999.0 0.0 -0.226 23.0 23.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.008 0.096 -9999.0 0.0 -0.207 23.0 23.0 mol:GDP -0.028 0.127 0.27 1.0 -0.297 21.0 22.0 CDC42/GTP/IQGAP1 0.042 0.009 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.028 0.037 -9999.0 0.0 -0.403 1.0 1.0 p120 catenin/RhoA/GDP -0.003 0.126 0.271 1.0 -0.268 21.0 22.0 RAC1/GTP/IQGAP1 0.029 0.021 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.043 0.029 -9999.0 0.0 -0.288 1.0 1.0 RHOA 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.016 0.054 0.111 11.0 -0.12 2.0 13.0 NME1 0.031 0.009 -9999.0 0.0 -9999.0 0.0 0.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.046 0.16 -9999.0 0.0 -0.411 23.0 23.0 regulation of cell-cell adhesion -0.015 0.067 -9999.0 0.0 -0.172 20.0 20.0 WASF2 0.006 0.039 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.005 0.095 -9999.0 0.0 -0.35 1.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.034 0.117 -9999.0 0.0 -0.218 25.0 25.0 CCND1 0.018 0.063 0.131 9.0 -0.146 2.0 11.0 VAV2 -0.046 0.21 -9999.0 0.0 -0.68 7.0 7.0 RAP1/GDP -0.004 0.103 -9999.0 0.0 -0.391 1.0 1.0 adherens junction assembly -0.044 0.155 -9999.0 0.0 -0.398 23.0 23.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.036 -9999.0 0.0 -0.403 1.0 1.0 regulation of heterotypic cell-cell adhesion 0.011 0.107 -9999.0 0.0 -0.213 25.0 25.0 E-cadherin/beta catenin -0.045 0.114 -9999.0 0.0 -0.305 23.0 23.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.047 0.158 -9999.0 0.0 -0.41 22.0 22.0 PIK3CA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.033 0.098 -9999.0 0.0 -0.386 3.0 3.0 E-cadherin/beta catenin/alpha catenin 0.008 0.112 -9999.0 0.0 -0.245 23.0 23.0 ITGAE 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.041 0.171 -9999.0 0.0 -0.42 24.0 24.0