Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.006 0.128 -9999.0 0.0 -0.489 9.0 9.0 IHH 0.02 0.052 -9999.0 0.0 -0.143 9.0 9.0 SHH Np/Cholesterol/GAS1 -0.013 0.075 -9999.0 0.0 -0.239 13.0 13.0 LRPAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.013 0.075 0.237 13.0 -9999.0 0.0 13.0 SMO/beta Arrestin2 0.044 0.118 -9999.0 0.0 -0.527 3.0 3.0 SMO -0.006 0.093 -9999.0 0.0 -0.486 4.0 4.0 AKT1 -0.003 0.099 -9999.0 0.0 -0.386 7.0 7.0 ARRB2 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.027 0.038 -9999.0 0.0 -0.403 1.0 1.0 ADRBK1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.006 0.092 -9999.0 0.0 -0.479 4.0 4.0 STIL 0.014 0.122 0.179 32.0 -0.318 7.0 39.0 DHH N/PTCH2 0.02 0.079 -9999.0 0.0 -0.291 8.0 8.0 DHH N/PTCH1 0.007 0.107 -9999.0 0.0 -0.313 13.0 13.0 PIK3CA 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.013 0.074 -9999.0 0.0 -0.403 4.0 4.0 PTHLH -0.016 0.155 -9999.0 0.0 -0.614 8.0 8.0 determination of left/right symmetry -0.006 0.092 -9999.0 0.0 -0.479 4.0 4.0 PIK3R1 0.03 0.01 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.015 0.154 -9999.0 0.0 -0.608 8.0 8.0 IHH N/Hhip -0.016 0.125 -9999.0 0.0 -0.329 18.0 18.0 DHH N/Hhip -0.015 0.12 -9999.0 0.0 -0.301 20.0 20.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.006 0.092 -9999.0 0.0 -0.479 4.0 4.0 pancreas development -0.033 0.141 -9999.0 0.0 -0.403 18.0 18.0 HHAT 0.025 0.051 -9999.0 0.0 -0.403 2.0 2.0 PI3K 0.044 0.014 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.01 0.075 -9999.0 0.0 -0.403 4.0 4.0 somite specification -0.006 0.092 -9999.0 0.0 -0.479 4.0 4.0 SHH Np/Cholesterol/PTCH1 -0.02 0.091 -9999.0 0.0 -0.329 7.0 7.0 SHH Np/Cholesterol/PTCH2 -0.009 0.071 -9999.0 0.0 -0.239 11.0 11.0 SHH Np/Cholesterol/Megalin -0.039 0.103 -9999.0 0.0 -0.249 26.0 26.0 SHH -0.032 0.07 -9999.0 0.0 -0.288 10.0 10.0 catabolic process -0.0 0.101 -9999.0 0.0 -0.37 9.0 9.0 SMO/Vitamin D3 -0.016 0.105 -9999.0 0.0 -0.475 4.0 4.0 SHH Np/Cholesterol/Hhip -0.026 0.083 -9999.0 0.0 -0.227 20.0 20.0 LRP2 -0.074 0.176 -9999.0 0.0 -0.403 32.0 32.0 receptor-mediated endocytosis -0.044 0.129 -9999.0 0.0 -0.438 9.0 9.0 SHH Np/Cholesterol/BOC -0.005 0.062 -9999.0 0.0 -0.222 10.0 10.0 SHH Np/Cholesterol/CDO -0.007 0.065 -9999.0 0.0 -0.222 11.0 11.0 mesenchymal cell differentiation 0.026 0.082 0.226 20.0 -9999.0 0.0 20.0 mol:Vitamin D3 0.028 0.132 0.195 32.0 -0.33 7.0 39.0 IHH N/PTCH2 0.027 0.07 -9999.0 0.0 -0.333 4.0 4.0 CDON 0.022 0.062 -9999.0 0.0 -0.403 3.0 3.0 IHH N/PTCH1 0.008 0.104 -9999.0 0.0 -0.372 9.0 9.0 Megalin/LRPAP1 -0.037 0.136 -9999.0 0.0 -0.288 32.0 32.0 PTCH2 0.018 0.071 -9999.0 0.0 -0.403 4.0 4.0 SHH Np/Cholesterol -0.01 0.058 -9999.0 0.0 -0.217 10.0 10.0 PTCH1 -0.0 0.101 -9999.0 0.0 -0.371 9.0 9.0 HHIP -0.033 0.142 -9999.0 0.0 -0.403 18.0 18.0