Stabilization and expansion of the E-cadherin adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations adherens junction organization -0.016 0.087 -9999.0 0.0 -0.209 23.0 23.0 epithelial cell differentiation 0.016 0.101 -9999.0 0.0 -0.21 23.0 23.0 CYFIP2 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.043 0.068 0.418 1.0 -9999.0 0.0 1.0 EGFR -0.071 0.161 -9999.0 0.0 -0.403 28.0 28.0 EPHA2 0.026 0.039 -9999.0 0.0 -0.403 1.0 1.0 MYO6 -0.045 0.073 0.167 3.0 -0.206 22.0 25.0 CTNNB1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 0.045 0.031 -9999.0 0.0 -9999.0 0.0 0.0 AQP5 -0.106 0.19 -9999.0 0.0 -0.462 29.0 29.0 CTNND1 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-4-5-P2 -0.045 0.072 0.166 3.0 -0.203 20.0 23.0 regulation of calcium-dependent cell-cell adhesion -0.051 0.084 0.166 3.0 -0.216 26.0 29.0 EGF 0.003 0.105 -9999.0 0.0 -0.403 9.0 9.0 NCKAP1 0.032 0.0 -9999.0 0.0 -9999.0 0.0 0.0 AQP3 -0.036 0.092 -9999.0 0.0 -0.369 5.0 5.0 cortical microtubule organization 0.016 0.101 -9999.0 0.0 -0.21 23.0 23.0 GO:0000145 -0.043 0.068 0.151 3.0 -0.193 22.0 25.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.105 -9999.0 0.0 -0.212 23.0 23.0 MLLT4 0.029 0.01 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GDP -0.057 0.058 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.03 0.008 -9999.0 0.0 -9999.0 0.0 0.0 Ephrin A1/EPHA2/NCK1/GIT1 0.068 0.045 -9999.0 0.0 -0.227 2.0 2.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 VASP -0.031 0.065 0.167 1.0 -9999.0 0.0 1.0 PVRL2 0.03 0.007 -9999.0 0.0 -9999.0 0.0 0.0 ZYX -0.037 0.069 0.174 2.0 -0.206 18.0 20.0 ARF6/GTP 0.074 0.045 -9999.0 0.0 -0.207 2.0 2.0 CDH1 -0.042 0.157 -9999.0 0.0 -0.403 23.0 23.0 EGFR/EGFR/EGF/EGF -0.057 0.115 -9999.0 0.0 -0.245 36.0 36.0 RhoA/GDP 0.023 0.099 -9999.0 0.0 -0.203 23.0 23.0 actin cytoskeleton organization -0.041 0.073 0.147 2.0 -0.206 22.0 24.0 IGF-1R heterotetramer 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 GIT1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 IGF1R 0.03 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IGF1 0.01 0.087 -9999.0 0.0 -0.403 6.0 6.0 DIAPH1 -0.091 0.241 -9999.0 0.0 -0.563 3.0 3.0 Wnt receptor signaling pathway -0.016 0.101 0.21 23.0 -9999.0 0.0 23.0 RHOA 0.032 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RhoA/GTP -0.058 0.059 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 VCL -0.042 0.074 0.149 2.0 -0.21 22.0 24.0 EFNA1 0.028 0.036 -9999.0 0.0 -0.403 1.0 1.0 LPP -0.048 0.069 0.152 2.0 -0.201 22.0 24.0 Ephrin A1/EPHA2 0.01 0.094 -9999.0 0.0 -0.204 21.0 21.0 SEC6/SEC8 -0.043 0.061 -9999.0 0.0 -0.2 18.0 18.0 MGAT3 -0.052 0.085 0.167 3.0 -0.219 26.0 29.0 HGF/MET -0.042 0.12 -9999.0 0.0 -0.244 33.0 33.0 HGF -0.009 0.103 -9999.0 0.0 -0.403 9.0 9.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN -0.015 0.087 -9999.0 0.0 -0.21 23.0 23.0 actin cable formation -0.025 0.07 0.373 1.0 -9999.0 0.0 1.0 KIAA1543 -0.051 0.074 0.148 2.0 -0.205 25.0 27.0 KIFC3 -0.05 0.069 0.153 1.0 -0.206 22.0 23.0 NCK1 0.031 0.005 -9999.0 0.0 -9999.0 0.0 0.0 EXOC3 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 ACTN1 -0.047 0.072 0.164 2.0 -0.205 23.0 25.0 NCK1/GIT1 0.046 0.009 -9999.0 0.0 -9999.0 0.0 0.0 mol:GDP 0.016 0.101 -9999.0 0.0 -0.21 23.0 23.0 EXOC4 0.022 0.015 -9999.0 0.0 -9999.0 0.0 0.0 STX4 -0.048 0.071 0.164 2.0 -0.205 23.0 25.0 PIP5K1C -0.045 0.072 0.167 3.0 -0.206 20.0 23.0 LIMA1 0.028 0.036 -9999.0 0.0 -0.403 1.0 1.0 ABI1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 ROCK1 -0.045 0.075 0.445 1.0 -9999.0 0.0 1.0 adherens junction assembly -0.042 0.084 0.245 1.0 -0.308 4.0 5.0 IGF-1R heterotetramer/IGF1 0.0 0.107 -9999.0 0.0 -0.213 27.0 27.0 nectin-2(dimer)/I-afadin/I-afadin/nectin-2(dimer/I-afadin/I-afadin 0.04 0.017 -9999.0 0.0 -9999.0 0.0 0.0 MET -0.03 0.125 -9999.0 0.0 -0.403 14.0 14.0 PLEKHA7 -0.053 0.078 0.164 2.0 -0.214 25.0 27.0 mol:GTP 0.065 0.044 -9999.0 0.0 -0.225 2.0 2.0 establishment of epithelial cell apical/basal polarity 0.011 0.125 0.31 5.0 -9999.0 0.0 5.0 cortical actin cytoskeleton stabilization -0.016 0.087 -9999.0 0.0 -0.209 23.0 23.0 regulation of cell-cell adhesion -0.041 0.073 0.147 2.0 -0.206 22.0 24.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin/EPLIN/cortical actin cytoskeleton -0.015 0.087 -9999.0 0.0 -0.21 23.0 23.0