E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN 0.008 0.05 -9999.0 0.0 -0.295 12.0 12.0 KLHL20 0.027 0.07 0.176 30.0 -0.193 15.0 45.0 CYFIP2 0.018 0.016 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GDP 0.005 0.042 0.165 12.0 -0.161 8.0 20.0 ENAH 0.005 0.053 -9999.0 0.0 -0.295 14.0 14.0 AP1M1 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.028 0.033 0.113 19.0 -0.116 7.0 26.0 ABI1/Sra1/Nap1 -0.011 0.024 -9999.0 0.0 -0.123 16.0 16.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.073 0.034 -9999.0 0.0 -0.075 1.0 1.0 RAPGEF1 -0.001 0.059 0.163 33.0 -0.274 10.0 43.0 CTNND1 0.03 0.015 -9999.0 0.0 -0.07 10.0 10.0 regulation of calcium-dependent cell-cell adhesion 0.02 0.055 -9999.0 0.0 -0.295 13.0 13.0 CRK 0.006 0.06 0.172 25.0 -0.286 12.0 37.0 E-cadherin/gamma catenin/alpha catenin 0.059 0.027 -9999.0 0.0 -0.058 20.0 20.0 alphaE/beta7 Integrin 0.046 0.011 -9999.0 0.0 -0.054 2.0 2.0 IQGAP1 0.008 0.043 -9999.0 0.0 -0.07 120.0 120.0 NCKAP1 0.032 0.002 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.036 0.019 -9999.0 0.0 -0.023 44.0 44.0 DLG1 0.006 0.054 -9999.0 0.0 -0.293 14.0 14.0 ChemicalAbstracts:7440-70-2 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.029 0.018 -9999.0 0.0 -0.091 11.0 11.0 MLLT4 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.036 0.017 -9999.0 0.0 -0.024 26.0 26.0 PI3K -0.036 0.022 -9999.0 0.0 -0.115 10.0 10.0 ARF6 0.031 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.043 0.022 -9999.0 0.0 -0.062 19.0 19.0 TIAM1 0.031 0.008 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin(dimer)/Ca2+ 0.067 0.034 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.016 0.036 0.148 7.0 -0.098 1.0 8.0 PIK3R1 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDH1 0.03 0.013 -9999.0 0.0 -0.07 8.0 8.0 RhoA/GDP 0.011 0.06 0.173 27.0 -0.165 15.0 42.0 actin cytoskeleton organization 0.023 0.056 0.144 31.0 -0.142 15.0 46.0 CDC42/GDP 0.011 0.058 0.172 23.0 -0.163 15.0 38.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.011 0.026 -9999.0 0.0 -0.103 20.0 20.0 ITGB7 0.032 0.008 -9999.0 0.0 -0.07 2.0 2.0 RAC1 0.023 0.015 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.072 0.036 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.052 0.022 -9999.0 0.0 -0.042 9.0 9.0 mol:GDP -0.002 0.062 0.171 28.0 -0.178 15.0 43.0 CDC42/GTP/IQGAP1 0.022 0.037 -9999.0 0.0 -0.043 119.0 119.0 JUP 0.029 0.018 -9999.0 0.0 -0.07 16.0 16.0 p120 catenin/RhoA/GDP 0.024 0.064 0.183 30.0 -0.169 16.0 46.0 RAC1/GTP/IQGAP1 0.015 0.033 -9999.0 0.0 -0.043 89.0 89.0 PIP5K1C/AP1M1 0.022 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.032 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.031 0.006 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.032 0.004 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.014 0.041 0.109 27.0 -0.095 16.0 43.0 NME1 -0.0 0.0 -9999.0 0.0 -0.0 2.0 2.0 clathrin coat assembly 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 0.006 0.053 -9999.0 0.0 -0.294 14.0 14.0 regulation of cell-cell adhesion -0.029 0.017 0.043 2.0 -0.098 11.0 13.0 WASF2 -0.006 0.013 -9999.0 0.0 -0.068 16.0 16.0 Rap1/GTP -0.022 0.045 0.141 30.0 -0.134 3.0 33.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.083 0.043 -9999.0 0.0 -0.081 5.0 5.0 CCND1 0.016 0.048 0.125 27.0 -0.115 16.0 43.0 VAV2 0.01 0.12 -9999.0 0.0 -0.547 17.0 17.0 RAP1/GDP -0.011 0.052 0.16 32.0 -0.179 1.0 33.0 adherens junction assembly 0.006 0.052 -9999.0 0.0 -0.287 14.0 14.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.025 0.014 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.03 0.009 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.054 0.038 0.189 3.0 -0.084 5.0 8.0 E-cadherin/beta catenin 0.005 0.022 -9999.0 0.0 -0.153 6.0 6.0 mol:GTP -0.0 0.0 -9999.0 0.0 -0.0 2.0 2.0 SRC 0.006 0.052 -9999.0 0.0 -0.294 13.0 13.0 PIK3CA 0.028 0.019 -9999.0 0.0 -0.07 17.0 17.0 Rac1/GTP -0.009 0.06 -9999.0 0.0 -0.285 17.0 17.0 E-cadherin/beta catenin/alpha catenin 0.06 0.023 -9999.0 0.0 -0.045 15.0 15.0 ITGAE 0.032 0.005 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin 0.021 0.056 -9999.0 0.0 -0.301 13.0 13.0