rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(3), CYP2C9(5) 922599 8 8 8 0 0 3 4 1 0 0 0.0867 0.0511 1.000 2 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 CMBL(2) 231812 2 2 2 0 0 0 0 0 2 0 0.660 0.111 1.000 3 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(12), GNAS(6), GNB1(2), PRKACA(4), PRKAR1A(2) 2991458 26 23 26 2 10 3 9 4 0 0 0.0192 0.150 1.000 4 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(2), B3GNT1(1), FUT1(1), FUT2(2), FUT9(10), GCNT2(4), ST8SIA1(2) 2797416 22 21 22 4 2 7 10 2 1 0 0.124 0.176 1.000 5 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(4), CYP2E1(5), PTGS1(6), PTGS2(2) 2433197 17 15 17 2 2 1 9 0 5 0 0.159 0.245 1.000 6 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 7 CCNE1(3), CDC34(1), CUL1(6), RB1(10), TFDP1(2) 2976526 22 21 22 4 3 4 2 2 11 0 0.197 0.314 1.000 7 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 GLUL(2), PGLYRP2(3) 829283 5 5 5 1 1 2 0 1 1 0 0.394 0.317 1.000 8 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADL(2), ACADM(3), ACADS(2), ECHS1(2), HADHA(3) 2467452 12 12 12 1 2 2 4 3 1 0 0.127 0.326 1.000 9 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALT(1), TGDS(2), UGDH(3), UXS1(2) 1758796 8 8 8 0 0 1 3 3 1 0 0.188 0.371 1.000 10 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 FABP6(2), LDLR(3), NR0B2(1), NR1H4(5), RXRA(4) 2480469 15 15 15 1 2 2 6 1 4 0 0.104 0.383 1.000 11 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 16 CSNK2A1(6), ELK1(1), FOS(1), MAP2K1(4), MAPK8(4), NGFR(1), PIK3R1(6), PLCG1(5), RAF1(2), SHC1(1), SOS1(7) 7493191 38 34 38 3 6 4 17 3 8 0 0.00916 0.427 1.000 12 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(2), FMOD(4), KERA(4) 1651973 10 8 10 2 0 4 5 0 1 0 0.317 0.438 1.000 13 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(2), IFNG(1), IL12A(1), IL12B(4) 1362330 8 8 8 2 1 2 0 4 1 0 0.515 0.456 1.000 14 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 BPNT1(1), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1) 2786733 13 11 13 0 1 4 4 3 1 0 0.0325 0.482 1.000 15 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 5 FOSB(1), GRIA2(10) 1693069 11 11 11 2 1 2 8 0 0 0 0.287 0.493 1.000 16 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALT(1), TGDS(2), UGDH(3), UGP2(1), UXS1(2) 2237857 9 9 9 0 0 1 4 3 1 0 0.158 0.518 1.000 17 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 11 APAF1(9), ARHGAP5(6), CASP1(2), CASP10(2), CASP3(1), GZMB(1), PRF1(3) 5346347 24 23 24 3 4 4 3 9 4 0 0.0741 0.527 1.000 18 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(2), NR3C1(5), RXRA(4) 2635335 11 11 11 0 2 1 4 2 2 0 0.0436 0.550 1.000 19 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA1(4), PSMA2(1), PSMA6(1), PSMB10(3), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMB8(1) 3977611 17 16 17 0 0 4 6 4 3 0 0.0122 0.568 1.000 20 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 NFYC(2), RB1(10), SP1(1), SP3(1) 3024881 14 14 14 3 0 1 1 2 10 0 0.581 0.632 1.000 21 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC3(1), PSMD14(2), RPN1(1), RPN2(2), UBE3A(4) 5879770 23 22 23 1 0 5 8 7 3 0 0.0157 0.674 1.000 22 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 12 BPNT1(1), CHST11(3), CHST12(1), CHST13(3), PAPSS1(3), PAPSS2(3), SULT1E1(3), SULT2A1(2), SUOX(1) 4218503 20 18 20 2 3 4 6 5 2 0 0.0581 0.676 1.000 23 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(3), EPHX2(4), RDH11(1), RDH12(3) 2186793 11 10 11 2 2 2 5 2 0 0 0.279 0.679 1.000 24 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A2(6), BCMO1(2) 1777605 8 8 8 2 2 1 2 1 2 0 0.458 0.680 1.000 25 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 CASP3(1), FOS(1), FYN(3), MAPK14(1), THBS1(7) 3373854 13 12 13 1 0 4 4 4 1 0 0.0798 0.683 1.000 26 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(2) 752631 2 2 2 0 1 1 0 0 0 0 0.450 0.690 1.000 27 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(3), ST3GAL1(1), ST3GAL4(1), ST3GAL5(2), ST6GALNAC2(2), ST8SIA1(2) 2580190 11 10 11 1 1 3 3 1 3 0 0.138 0.697 1.000 28 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(2), HLA-DRA(1) 1077093 3 3 3 1 0 1 0 1 1 0 0.732 0.725 1.000 29 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 FAH(1), HGD(2) 1018738 3 3 3 1 1 1 1 0 0 0 0.607 0.726 1.000 30 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 11 CCNA1(4), CCNA2(3), CCND1(2), CCNE1(3), CCNE2(3), CDK4(4), CDKN1B(2), E2F2(3), E2F4(1) 3534087 25 24 25 5 1 7 5 8 4 0 0.197 0.748 1.000 31 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(2), HADHA(3) 2211166 7 7 7 0 0 1 1 3 2 0 0.159 0.749 1.000 32 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDFT1(3), FDPS(2), IDI1(1) 1460995 6 6 6 2 2 3 1 0 0 0 0.481 0.751 1.000 33 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2) 2570828 13 12 13 3 1 5 1 3 3 0 0.407 0.761 1.000 34 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIPT1(1) 695872 1 1 1 0 0 0 0 1 0 0 0.757 0.787 1.000 35 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 ACTA1(2), RAB1A(1), RAB3A(1), RAB5A(2) 1919717 6 6 6 0 2 2 1 1 0 0 0.115 0.791 1.000 36 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(4), CCNE1(3), CDC34(1), CUL1(6), RB1(10), SKP2(2), TFDP1(2) 3866305 28 26 28 7 4 4 5 3 12 0 0.391 0.799 1.000 37 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 16 AKT1(2), ANXA1(1), CALM1(1), CALM3(1), GNAS(6), GNB1(2), NFKB1(2), NOS3(4), NPPA(1), NR3C1(5), PIK3R1(6), RELA(1), SYT1(5) 7157306 37 31 37 4 11 8 6 8 4 0 0.0147 0.804 1.000 38 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(3), CDKN1B(2), CKS1B(1), CUL1(6), NEDD8(1), RB1(10), RBX1(2), SKP2(2), TFDP1(2) 3895401 29 28 29 7 3 5 5 4 12 0 0.328 0.817 1.000 39 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 18 ADCY1(12), ARHGEF1(5), F2(2), F2RL3(3), GNA12(1), GNA13(1), GNAI1(1), GNB1(2), MAP3K7(4), PIK3R1(6), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2B(2), ROCK1(11) 10791239 65 57 65 9 11 12 25 12 5 0 0.00532 0.822 1.000 40 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 ADRA1B(1), PLCD1(2), PRKCA(2), TGM2(3) 2255806 8 8 8 1 0 3 3 2 0 0 0.172 0.828 1.000 41 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(1), ALDOB(3), ALDOC(1), TPI1(2) 1785922 7 7 7 2 1 2 2 2 0 0 0.543 0.844 1.000 42 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(5), PARK2(3), SNCAIP(1), UBE2L3(1), UBE2L6(1) 2927495 11 10 11 2 1 2 2 4 2 0 0.360 0.844 1.000 43 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 18 CSNK2A1(6), ELK1(1), EPO(2), FOS(1), JAK2(2), MAP2K1(4), MAPK8(4), PLCG1(5), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(4) 9569935 41 36 41 4 7 7 19 1 7 0 0.00442 0.846 1.000 44 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ACAT2(1), ACYP1(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3) 3564134 10 10 10 1 1 2 1 4 2 0 0.182 0.848 1.000 45 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 16 CD28(2), CD3D(1), CD80(5), CD86(1), CTLA4(1), HLA-DRA(1), ICOS(1), ITK(1), LCK(5), PIK3R1(6), PTPN11(1) 4824124 25 21 25 4 1 7 5 6 6 0 0.117 0.851 1.000 46 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(4), FYN(3), LRP8(1), RELN(34), VLDLR(1) 6372797 43 37 43 7 5 5 13 15 5 0 0.108 0.856 1.000 47 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(2), CD86(1), HLA-DRA(1), IFNG(1), IFNGR1(4), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL2RA(2), IL4(1), IL4R(2) 5765533 33 30 32 5 3 9 9 6 6 0 0.0366 0.887 1.000 48 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3D(1) 516198 1 1 1 0 0 0 1 0 0 0 0.843 0.889 1.000 49 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(7), GOT1(1), GOT2(2), TAT(1), TYR(4) 2142884 15 14 15 4 1 2 8 1 3 0 0.503 0.893 1.000 50 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA1(4), ADORA2A(1), ADORA3(2), LTB4R(2), P2RY1(3), P2RY2(2), P2RY6(2) 2718389 16 14 16 4 3 5 6 2 0 0 0.160 0.901 1.000 51 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 ACAT2(1), HMGCL(1), OXCT1(1) 1542084 3 3 3 1 1 0 0 1 1 0 0.692 0.907 1.000 52 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDFT1(3), FDPS(2), IDI1(1) 1951946 6 6 6 2 2 3 1 0 0 0 0.482 0.910 1.000 53 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 11 APC(17), CDH1(4), CREBBP(15), MAP2K1(4), MAP3K7(4), SKIL(4), TGFB1(1), TGFB2(2), TGFBR1(1) 8909934 52 44 52 9 6 8 21 8 9 0 0.177 0.920 1.000 54 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(4), GAD1(2), HDC(2), PNMT(1), TH(2), TPH1(2) 2763324 13 13 13 3 2 1 6 1 3 0 0.476 0.923 1.000 55 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(2), CD80(5), HLA-DRA(1), IL4(1) 1807437 9 9 9 3 0 4 2 2 1 0 0.525 0.925 1.000 56 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 13 AKT1(2), BAD(1), IGF1R(7), IRS1(1), MAP2K1(4), MAPK1(4), PIK3R1(6), RAF1(2), SHC1(1), SOS1(7), YWHAH(1) 7453630 36 32 33 5 8 8 11 5 4 0 0.0311 0.929 1.000 57 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(3), AOC2(2), AOC3(5), CES1(4), ESD(1) 2756712 15 15 15 4 1 6 6 0 2 0 0.320 0.932 1.000 58 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(2), CD3D(1) 1461751 3 3 3 1 0 0 1 1 1 0 0.841 0.932 1.000 59 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25B(3), NEK1(4), WEE1(1) 3132462 8 8 8 1 2 1 4 0 1 0 0.556 0.935 1.000 60 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD2(1), CD34(4), CD3D(1), CD58(1), CD8A(2), IL3(1) 2820651 10 10 10 3 2 1 2 1 4 0 0.618 0.941 1.000 61 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 SNAP25(1), STX1A(2) 1483617 3 3 3 1 1 0 1 1 0 0 0.756 0.942 1.000 62 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 LHPP(1), MTMR2(5), MTMR6(2), NFS1(1), PHPT1(1), TPK1(3) 2920637 13 11 13 3 3 2 3 3 2 0 0.484 0.942 1.000 63 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CARM1(3), CHPT1(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PCYT1A(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2) 6395286 28 26 28 4 9 7 7 2 3 0 0.0385 0.943 1.000 64 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 4 ADAM17(4), DLL1(4), FURIN(1) 2369375 9 9 9 2 3 2 2 1 1 0 0.350 0.944 1.000 65 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 9 ACTA1(2), EPHA4(9), EPHB1(9), FYN(3), ITGA1(3), L1CAM(3), LYN(3), RAP1B(2), SELP(11) 6415962 45 36 45 8 4 8 12 13 8 0 0.108 0.944 1.000 66 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(1), GPI(2), HK1(3), PFKL(4), PGAM1(1), PKLR(1), TPI1(2) 4218425 17 16 17 3 6 3 1 4 3 0 0.215 0.948 1.000 67 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(12), TUB(2) 3252404 17 17 17 4 5 3 7 2 0 0 0.298 0.948 1.000 68 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(1), GOT2(2), TAT(1) 1197770 4 4 4 2 0 0 3 1 0 0 0.828 0.949 1.000 69 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), ST3GAL3(1) 2320444 10 10 10 3 2 3 2 1 2 0 0.446 0.949 1.000 70 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNG(1), IFNGR1(4), IFNGR2(2), JAK1(6), JAK2(2), STAT1(5) 3727435 20 19 19 6 1 5 4 2 8 0 0.406 0.954 1.000 71 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ACAA2(1), ACAT2(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2) 3809273 11 11 11 2 1 1 3 4 2 0 0.369 0.954 1.000 72 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1) 3173054 8 8 8 1 1 3 2 1 1 0 0.257 0.964 1.000 73 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), PRKCE(2) 3578364 31 28 31 9 2 6 12 5 6 0 0.502 0.965 1.000 74 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 17 APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIK(1), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), DIABLO(1) 5584704 23 22 23 4 4 6 5 4 4 0 0.146 0.969 1.000 75 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CCR3(3), HLA-DRA(1), IL1B(1), IL4(1), IL5(1), IL5RA(1) 2426471 8 8 8 2 0 4 4 0 0 0 0.379 0.972 1.000 76 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SEC61A2(2), SRP19(1), SRP68(1), SRPR(2) 3433083 7 7 7 1 0 2 4 1 0 0 0.416 0.976 1.000 77 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDHB(1), BCKDK(3), CTH(2), MUT(2) 2232722 8 7 8 2 0 4 3 0 1 0 0.464 0.977 1.000 78 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 14 APAF1(9), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP7(1), GZMB(1), PRF1(3), SCAP(1), SREBF1(3), SREBF2(3) 7763449 26 24 26 3 6 4 7 6 3 0 0.0361 0.980 1.000 79 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(7), ACO2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1) 4056012 15 13 15 3 1 5 6 2 1 0 0.274 0.982 1.000 80 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 11 CREB1(1), FOS(1), MAPK1(4), MAPK14(1), MAPK8(4), PRKCA(2) 2972328 13 13 10 4 3 1 6 0 3 0 0.599 0.984 1.000 81 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 13 AKT1(2), BAD(1), CHUK(3), GH1(1), GHR(4), NFKB1(2), PDPK1(2), PIK3R1(6), RELA(1), YWHAH(1) 5434076 23 21 23 4 2 9 2 6 4 0 0.137 0.985 1.000 82 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 17 CSNK2A1(6), ELK1(1), FOS(1), IGF1R(7), IRS1(1), MAP2K1(4), MAPK8(4), PIK3R1(6), PTPN11(1), RAF1(2), SHC1(1), SOS1(7) 9163227 41 37 41 6 6 5 17 5 8 0 0.0532 0.985 1.000 83 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 CS(2), MDH1(1), ME1(2), PC(7), PDHA1(3), SLC25A1(1) 4234898 16 16 16 4 3 5 3 3 2 0 0.375 0.985 1.000 84 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(3), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4) 6131663 24 22 24 4 2 5 10 2 5 0 0.131 0.986 1.000 85 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 11 AKT1(2), CAT(2), GH1(1), GHR(4), IGF1R(7), PIK3R1(6), SHC1(1), SOD2(1), SOD3(1) 4866227 25 24 25 5 5 7 6 5 2 0 0.161 0.986 1.000 86 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 14 AKT1(2), BCAR1(2), CDKN1B(2), ILK(4), MAPK1(4), PDPK1(2), PIK3R1(6), PTEN(6), PTK2(5), SHC1(1), SOS1(7) 7047668 41 36 38 8 4 7 13 6 11 0 0.143 0.988 1.000 87 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 B3GALT5(1), FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST8SIA1(2) 4897881 28 25 28 6 1 5 13 4 5 0 0.240 0.989 1.000 88 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 6 AKT1(2), PIK3R1(6), PLCB1(12), PLCG1(5), PRKCA(2), VAV1(2) 4839318 29 27 29 6 3 6 13 5 2 0 0.250 0.990 1.000 89 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 8 CISH(1), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), SOAT1(3) 6077563 24 23 24 4 4 5 6 3 6 0 0.141 0.992 1.000 90 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(12), FHL5(4), FSHB(1), FSHR(5), GNAS(6), XPO1(3) 4347116 31 29 31 6 8 6 10 7 0 0 0.199 0.993 1.000 91 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(3), B4GALNT1(2), GLB1(4), HEXA(3), LCT(8), SLC33A1(1), ST3GAL1(1), ST3GAL5(2), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4) 7487856 40 35 40 8 7 10 10 9 4 0 0.0779 0.994 1.000 92 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 18 CSNK2A1(6), ELK1(1), FOS(1), INSR(2), IRS1(1), MAP2K1(4), MAPK8(4), PIK3R1(6), PTPN11(1), RAF1(2), SHC1(1), SLC2A4(1), SOS1(7) 9487041 37 32 37 5 4 5 16 4 8 0 0.0432 0.995 1.000 93 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 6 MAX(1), MYC(3), SP1(1), SP3(1) 2843487 6 6 6 2 0 1 3 1 1 0 0.762 0.995 1.000 94 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 14 CUZD1(3), FOS(1), MAP2K1(4), MAPK1(4), MYC(3), NFKB1(2), PLCB1(12), PRKCA(2), RAF1(2), RELA(1) 6893555 34 34 31 8 8 6 14 3 3 0 0.158 0.995 1.000 95 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 CEBPB(1), CSNK2A1(6), ELK1(1), FOS(1), IL6R(4), IL6ST(2), JAK1(6), JAK2(2), JAK3(3), MAP2K1(4), PTPN11(1), RAF1(2), SHC1(1), SOS1(7), STAT3(3) 10638274 44 39 43 7 6 5 17 8 8 0 0.0523 0.996 1.000 96 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 ACAT2(1), BDH1(1), BDH2(1), HMGCL(1), HMGCS1(2), HMGCS2(2), OXCT1(1), OXCT2(1) 3277286 10 9 10 3 3 1 2 3 1 0 0.569 0.996 1.000 97 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 15 AKT1(2), CREB1(1), MAPK1(4), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NTRK1(3), PIK3R1(6), PLCG1(5), RPS6KA1(4), SHC1(1) 7426817 37 32 34 6 7 10 9 6 5 0 0.0422 0.996 1.000 98 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 21 ACTA1(2), ADCY1(12), CAP1(2), CCNB1(3), GNAI1(1), GNAS(6), GNB1(2), MAPK1(4), MYT1(7), PIN1(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RPS6KA1(4), SRC(1) 9140987 53 47 50 9 18 9 15 9 2 0 0.0109 0.996 1.000 99 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), CAMK1G(1), HDAC9(11), MEF2A(1), MEF2B(2), MEF2C(7), YWHAH(1) 3486563 24 22 24 7 3 5 10 3 3 0 0.440 0.996 1.000 100 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 8 CISH(1), IFNG(1), IFNGR1(4), JAK1(6), JAK2(2), PTPRU(6), STAT1(5) 5049247 25 24 24 6 4 7 4 2 8 0 0.168 0.996 1.000 101 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AADAT(1), AASDHPPT(3), KARS(2) 2143652 6 6 6 3 0 1 1 2 2 0 0.863 0.997 1.000 102 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 21 CSNK2A1(6), ELK1(1), FOS(1), IL2RA(2), IL2RB(3), JAK1(6), JAK3(3), LCK(5), MAP2K1(4), MAPK8(4), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(4), SYK(2) 10403288 52 42 52 9 7 9 21 5 10 0 0.0240 0.997 1.000 103 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(10), GNA12(1), PRKACB(2), PRKACG(1), PRKAR2B(2) 4572101 16 14 16 3 2 9 3 2 0 0 0.127 0.997 1.000 104 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 17 ADAM10(3), ANKRD1(1), DUSP14(1), EIF4EBP1(1), IFNG(1), IFRD1(2), IL1A(1), IL1R1(2), MYOG(3), NR4A3(2) 4869061 17 15 17 3 2 5 4 5 1 0 0.236 0.997 1.000 105 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), FUT2(2), FUT9(10), GBGT1(2), GLA(3), HEXA(3), NAGA(3), ST3GAL1(1), ST3GAL4(1), ST8SIA1(2) 4614870 28 25 28 7 1 6 12 4 5 0 0.318 0.997 1.000 106 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ADAM17(4), ERBB4(15), NRG2(4), NRG3(8), PRKCA(2) 4087307 33 28 33 9 4 5 13 8 3 0 0.481 0.997 1.000 107 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(5) 2209291 5 4 5 2 1 2 1 1 0 0 0.737 0.998 1.000 108 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), DAG1(1), ITPKA(1), ITPKB(4) 2748280 7 5 7 2 2 2 2 1 0 0 0.408 0.998 1.000 109 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(7), ACO2(2), AFMID(3), CS(2), HAO1(5), HAO2(1), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1) 6097801 27 23 27 5 2 6 9 6 4 0 0.179 0.998 1.000 110 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMPR1B(1), BMPR2(3) 2852136 4 4 4 1 0 1 2 1 0 0 0.693 0.998 1.000 111 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ACAA2(1), ECHS1(2), HADHA(3), HADHB(2), HSD17B4(3), PPT1(1), PPT2(1) 3860702 13 13 13 4 0 2 3 6 2 0 0.581 0.999 1.000 112 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 15 CD28(2), CD3D(1), IFNG(1), IL2RA(2), IL4(1), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR3(3), TOB2(2) 4287563 16 15 16 4 1 5 4 4 2 0 0.446 0.999 1.000 113 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 14 CSF2RB(5), FOS(1), IL3(1), IL3RA(3), JAK2(2), MAP2K1(4), PTPN6(1), RAF1(2), SHC1(1), SOS1(7), STAT5A(1), STAT5B(4) 7857773 32 29 32 6 5 10 11 3 3 0 0.0560 0.999 1.000 114 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(2), CDO1(1), CSAD(2), GAD1(2), GAD2(2), GGT1(1) 2616298 10 10 10 4 2 3 1 1 3 0 0.701 0.999 1.000 115 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNG(1), IL12A(1), IL12B(4), IL13(1), IL16(11), IL1A(1), IL3(1), IL4(1), IL5(1), IL9(1), LTA(1) 4526342 24 22 24 7 8 6 4 5 1 0 0.290 0.999 1.000 116 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F10(3), F2(2), F3(1), F5(12), F7(2), FGA(7), FGB(2), FGG(3), PROS1(5), SERPINC1(3) 7476710 40 33 40 8 2 9 16 6 7 0 0.118 0.999 1.000 117 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 18 AKT1(2), BAD(1), BCL2L1(2), CDC42(1), CHUK(3), ELK1(1), MAP2K1(4), NFKB1(2), PIK3R1(6), RAF1(2), RALBP1(2), RALGDS(6), RELA(1), RHOA(4) 7296671 37 30 34 7 7 9 12 3 6 0 0.114 0.999 1.000 118 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 12 ARNT(4), ASPH(7), COPS5(1), CREB1(1), EPO(2), HIF1A(2), LDHA(1), NOS3(4), P4HB(1) 5498088 23 23 23 5 8 4 5 3 3 0 0.202 0.999 1.000 119 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 10 AKT1(2), NTRK1(3), PIK3R1(6), PLCG1(5), PRKCA(2), SHC1(1), SOS1(7) 5901382 26 23 26 5 3 7 9 5 2 0 0.185 0.999 1.000 120 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(2), B3GALT1(1), B3GALT2(1), B3GALT5(1), B3GNT5(2), FUT1(1), FUT2(2), ST3GAL3(1), ST3GAL4(1) 3283505 12 11 12 5 2 2 4 0 4 0 0.826 0.999 1.000 121 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(15), GZMA(1), GZMB(1), HMGB2(1), PRF1(3), SET(1) 4837360 22 21 22 6 3 4 8 5 2 0 0.438 0.999 1.000 122 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(2), CTH(2), GOT1(1), GOT2(2), LDHA(1), LDHB(1), LDHC(3) 3118783 12 12 12 4 3 0 7 2 0 0 0.648 0.999 1.000 123 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 6 ATM(9), ATR(18), CHEK2(4), YWHAH(1) 6914301 32 29 32 5 2 8 7 12 3 0 0.165 0.999 1.000 124 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(7), ACO2(2), CS(2), HAO1(5), HAO2(1), MDH1(1), MTHFD1(2), MTHFD1L(3), MTHFD2(1) 5821305 24 21 24 5 2 6 8 5 3 0 0.228 0.999 1.000 125 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AADAT(1), AASDH(3), AASDHPPT(3), KARS(2) 3161374 9 9 9 4 0 1 2 3 3 0 0.830 0.999 1.000 126 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 12 MDM2(2), MYC(3), PIK3R1(6), POLR1A(5), POLR1B(3), POLR1C(2), RB1(10), TBX2(2), TWIST1(1) 7400100 34 31 34 8 4 6 6 4 14 0 0.258 0.999 1.000 127 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(1), COQ6(1), COQ7(1), NDUFA12(1), NDUFA13(2) 1824339 6 6 6 4 0 2 2 1 1 0 0.934 0.999 1.000 128 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 GPD2(2), SDHA(4), SDHC(1), UQCRC1(1) 3015547 8 8 8 3 0 1 3 3 1 0 0.698 0.999 1.000 129 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(6) 3846743 7 7 7 2 2 0 2 1 2 0 0.730 1.000 1.000 130 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(20), MAP2(13), PRKACB(2), PRKACG(1), PRKAR2B(2), PRKCE(2) 8254538 40 33 40 8 2 6 14 8 10 0 0.373 1.000 1.000 131 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3D(1), FYN(3), HLA-DRA(1), LCK(5), PTPRC(13), ZAP70(2) 4113288 25 21 25 8 2 6 5 7 5 0 0.392 1.000 1.000 132 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CCNB1(3), CDC25B(3), CSK(1), PRKCA(2), PTPRA(4), SRC(1) 4193055 14 13 14 4 4 3 6 1 0 0 0.361 1.000 1.000 133 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 11 EGR1(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NGFR(1), RAF1(2) 3514191 17 16 14 6 7 1 4 1 4 0 0.524 1.000 1.000 134 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(6), EGFR(14), ERBB3(8), NRG1(1) 4690084 29 26 29 8 4 6 8 7 4 0 0.420 1.000 1.000 135 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(2), LDLR(3), MBTPS1(8), MBTPS2(1), SCAP(1), SREBF1(3), SREBF2(3) 5420463 21 19 21 5 2 4 8 5 2 0 0.348 1.000 1.000 136 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA1(1), ANXA3(1), ANXA4(1), ANXA6(4), CYP11A1(2), EDNRB(3), HSD11B2(1), PLA2G4A(3), PRL(3), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5) 9389909 44 35 43 8 11 5 11 8 9 0 0.0441 1.000 1.000 137 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 11 ATM(9), CDC25B(3), CDK4(4), MYT1(7), RB1(10), WEE1(1), YWHAH(1) 7615917 35 33 35 7 3 6 10 6 10 0 0.341 1.000 1.000 138 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BAD(1), BRAF(4), CREB1(1), CREB5(5), DUSP4(1), DUSP6(3), DUSP9(1), EEF2K(4), MAP2K1(4), MAP2K2(3), MAP3K8(1), MAPK1(4), MKNK1(1), MKNK2(1), MOS(5), NFKB1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), SHC1(1), SOS1(7), SOS2(9), TRAF3(3) 13427113 74 55 70 11 15 15 23 12 9 0 0.00453 1.000 1.000 139 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 8 CHUK(3), DNAJC3(1), EIF2S1(1), EIF2S2(3), MAP3K14(2), NFKB1(2), RELA(1) 4100676 13 12 13 5 2 3 2 2 4 0 0.828 1.000 1.000 140 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(2), CSF1(1), LDLR(3), LPL(2) 2422249 8 8 8 4 1 1 4 1 1 0 0.853 1.000 1.000 141 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 11 FOS(1), IFNAR1(2), IFNAR2(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF11A(2), TNFSF11(1), TRAF6(1) 4773990 15 15 15 4 3 4 4 3 1 0 0.466 1.000 1.000 142 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 10 CISH(1), IL6R(4), JAK1(6), JAK2(2), JAK3(3), PIAS3(3), PTPRU(6), SRC(1), STAT3(3) 6766295 29 28 28 6 5 5 7 7 5 0 0.160 1.000 1.000 143 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 7 CREB1(1), HBXIP(1), PTK2B(2), SHC1(1), SOS1(7), SRC(1) 3823592 13 12 13 4 3 2 5 2 1 0 0.565 1.000 1.000 144 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), DHFR(3), FPGS(2) 2971869 16 14 16 6 2 1 9 2 2 0 0.682 1.000 1.000 145 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 APAF1(9), BAD(1), BAX(1), BCL10(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), CASP8AP2(3), CES1(4) 4964296 25 23 25 6 3 8 6 4 4 0 0.362 1.000 1.000 146 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 12 CCND1(2), CDK4(4), CDKN1B(2), CFL1(2), E2F2(3), MDM2(2) 2909457 15 13 15 6 1 4 4 4 2 0 0.659 1.000 1.000 147 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(12), CFTR(7), GNAS(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SLC9A3R1(1) 5944860 34 30 34 8 10 6 12 6 0 0 0.200 1.000 1.000 148 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3) 3002239 17 17 17 6 3 2 6 3 3 0 0.516 1.000 1.000 149 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(4), HS3ST2(2), HS3ST3B1(1), XYLT1(7), XYLT2(3) 3002239 17 17 17 6 3 2 6 3 3 0 0.516 1.000 1.000 150 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(17), ASAH1(1), CASP3(1), CERK(2), CREB1(1), CREB5(5), CXCL2(1), DAG1(1), EPHB2(2), FOS(1), ITPKA(1), ITPKB(4), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4) 12987964 63 52 60 10 12 13 20 7 11 0 0.0175 1.000 1.000 151 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B3GNT1(1), B4GALT2(3), B4GALT5(2), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 3610573 11 10 11 4 2 2 2 2 3 0 0.692 1.000 1.000 152 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(1), ENO3(1), FARS2(2), GOT1(1), GOT2(2), PAH(4), TAT(1), YARS(3) 3783264 15 12 15 7 0 4 5 3 3 0 0.789 1.000 1.000 153 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(2), PLCG1(5), PRKCA(2), PTK2B(2) 3053975 11 11 11 4 2 2 5 2 0 0 0.492 1.000 1.000 154 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 20 APAF1(9), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), GZMB(1), LMNB1(1), LMNB2(4), PRF1(3) 8262676 29 28 29 6 7 5 7 7 3 0 0.176 1.000 1.000 155 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD8A(2), CSF1(1), EPO(2), IL3(1), IL4(1), IL5(1), IL9(1) 2773360 9 9 9 7 4 1 2 1 1 0 0.944 1.000 1.000 156 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX3(1), FADS2(2), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1) 4623164 12 11 12 4 2 1 4 2 3 0 0.599 1.000 1.000 157 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM1(1), CALM3(1), CCL2(2), CXCL12(1), CXCR4(1), FOS(1), MAPK14(1), MAPK8(4), PLCG1(5), PRKCA(2), PTK2B(2), SYT1(5) 6275083 26 22 26 6 3 3 14 5 1 0 0.291 1.000 1.000 158 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 ARRB1(2), GNAS(6), GNB1(2), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2) 4344323 20 17 20 5 8 5 5 2 0 0 0.279 1.000 1.000 159 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX12(2), ALOX15(1), ALOX15B(2), ALOX5(2), DPEP1(2), GGT1(1), PLA2G6(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5) 6863320 27 25 27 6 5 4 9 4 5 0 0.112 1.000 1.000 160 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), TYR(4) 4427430 24 22 24 8 2 4 13 1 4 0 0.734 1.000 1.000 161 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 CARM1(3), DHRS1(1), DHRS2(3), DHRS7(1), HEMK1(1), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2) 6838421 31 29 31 8 8 8 8 4 3 0 0.199 1.000 1.000 162 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 23 GH1(1), GHR(4), INSR(2), IRS1(1), JAK2(2), MAP2K1(4), MAPK1(4), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN6(1), RAF1(2), RPS6KA1(4), SHC1(1), SLC2A4(1), SOS1(7), STAT5A(1), STAT5B(4) 13867482 52 45 49 8 10 15 16 6 5 0 0.00498 1.000 1.000 163 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(1), EIF2AK4(6), EIF2B5(2), EIF2S1(1), EIF2S2(3), EIF5(2), GSK3B(1) 5274480 16 15 16 8 3 3 5 0 5 0 0.953 1.000 1.000 164 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNB1(3), CDC25B(3), MNAT1(2), XPO1(3) 3932458 11 11 11 4 4 3 2 2 0 0 0.593 1.000 1.000 165 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 AHCY(1), CARM1(3), CTH(2), GGT1(1), HEMK1(1), LCMT1(1), LCMT2(6), MARS(2), MARS2(4), MAT1A(1), METTL2B(2), METTL6(2), PAPSS1(3), PAPSS2(3), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SEPHS1(1), SEPHS2(3) 11353289 47 39 46 8 12 13 13 5 4 0 0.0179 1.000 1.000 166 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(2), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALT2(3), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GCNT2(4), ST3GAL6(1), ST8SIA1(2) 7367361 37 33 37 9 4 12 14 3 4 0 0.120 1.000 1.000 167 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2) 3636958 11 11 11 7 3 1 3 1 3 0 0.921 1.000 1.000 168 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2) 3636958 11 11 11 7 3 1 3 1 3 0 0.921 1.000 1.000 169 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), PGM1(3), PGM3(1), TGDS(2) 4651478 21 20 21 6 4 4 7 3 3 0 0.455 1.000 1.000 170 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 16 B3GAT3(4), CHPF(4), CHST11(3), CHST12(1), CHST13(3), CHST14(1), CHSY1(2), UST(1), XYLT1(7), XYLT2(3) 6353940 29 28 29 7 6 2 12 5 4 0 0.265 1.000 1.000 171 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACO1(7), ACO2(2), ACSS1(5), ACSS2(2), FH(2), IDH1(2), MDH1(1), SUCLA2(1) 6056947 22 19 22 6 2 6 7 3 4 0 0.403 1.000 1.000 172 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(3), MAP3K14(2), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF13B(2), TNFRSF13C(2), TNFSF13(1), TNFSF13B(1), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1) 6641117 25 25 24 7 2 5 10 1 7 0 0.598 1.000 1.000 173 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 8 HSD17B3(1), HSD17B4(3), HSD3B1(2), HSD3B2(2) 3068995 8 8 8 4 1 3 2 1 1 0 0.734 1.000 1.000 174 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 19 F2(2), F2RL3(3), GNAI1(1), GNB1(2), ITGA1(3), MAP2K1(4), MAPK1(4), PLA2G4A(3), PLCB1(12), PRKCA(2), PTGS1(6), PTK2(5), RAF1(2), SRC(1), SYK(2), TBXAS1(5) 10124655 57 49 54 12 11 5 22 11 8 0 0.112 1.000 1.000 175 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ACY1(2), ALDH18A1(2), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), NAGS(2), ODC1(1), OTC(1), PYCR1(1), SMS(2) 7984329 33 31 33 7 7 9 10 7 0 0 0.105 1.000 1.000 176 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 20 ADCY1(12), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGAV(2), ITGB3(5), MAPK1(4), PDGFRA(6), PIK3R1(6), PLCB1(12), PRKCA(2), PTK2(5), SMPD1(1), SMPD2(1), SRC(1) 11310688 63 59 60 13 12 10 23 9 9 0 0.0610 1.000 1.000 177 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 12 ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), PAK1(1), PDGFRA(6), PIK3R1(6), WASL(1) 4903636 20 20 20 8 2 4 5 5 4 0 0.838 1.000 1.000 178 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(4), CYP2A13(2), CYP2A7(2), NAT1(1), XDH(3) 3638553 12 11 12 5 1 2 4 3 2 0 0.753 1.000 1.000 179 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 20 AKT1(2), EIF4A1(1), EIF4B(2), EIF4EBP1(1), EIF4G1(12), EIF4G2(3), EIF4G3(4), MKNK1(1), PDPK1(2), PIK3R1(6), PTEN(6), RPS6KB1(3), TSC1(2), TSC2(3) 11622216 48 40 48 8 0 12 19 5 12 0 0.0882 1.000 1.000 180 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 15 KLRC2(1), KLRC3(2), KLRC4(1), LAT(3), MAP2K1(4), PAK1(1), PIK3R1(6), PTK2B(2), PTPN6(1), SYK(2), VAV1(2) 6042192 25 22 25 7 5 1 6 7 6 0 0.559 1.000 1.000 181 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 23 ADCY1(12), AKT1(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), GNAS(6), MAPK1(4), MAPK14(1), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RPS6KA1(4), RPS6KA5(4), SOS1(7) 11855351 63 53 60 11 13 15 18 10 7 0 0.0186 1.000 1.000 182 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(4), ADSS(2), DHFR(3), HPRT1(1), IMPDH1(3), MTHFD2(1), OAZ1(1), POLB(1), POLD1(3), POLG(2), PRPS2(1), RRM1(1) 5688117 23 21 23 6 5 3 12 0 3 0 0.292 1.000 1.000 183 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 14 BCL2(1), CREBBP(15), FYN(3), IL7R(3), JAK1(6), JAK3(3), LCK(5), NMI(5), PIK3R1(6), PTK2B(2), STAT5A(1), STAT5B(4) 9477350 54 43 54 11 3 14 15 13 9 0 0.0453 1.000 1.000 184 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 CKM(2), LDHA(1), LDHB(1), LDHC(3), MAPK14(1), NCL(3) 4092084 11 11 11 6 2 0 4 3 2 0 0.935 1.000 1.000 185 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 ACO2(2), CS(2), FH(2), MDH1(1), OGDH(6), SDHA(4), SUCLA2(1) 4286283 18 17 18 6 1 2 9 4 2 0 0.755 1.000 1.000 186 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BRAF(4), CREB1(1), CREB5(5), MAPK1(4), RAF1(2), SRC(1) 5080555 18 15 15 5 4 2 8 1 3 0 0.563 1.000 1.000 187 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CAMKK1(1), CAMKK2(5), CREB1(1), SYT1(5) 5260732 22 22 22 7 3 4 7 5 3 0 0.605 1.000 1.000 188 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 18 CALM1(1), CALM3(1), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), SP1(1), SP3(1), SYT1(5) 9559825 37 32 37 8 10 7 10 7 3 0 0.0781 1.000 1.000 189 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2) 4776708 15 14 15 6 3 4 4 1 3 0 0.694 1.000 1.000 190 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13(1), IL13RA1(1), IL13RA2(1), IL4R(2), JAK1(6), JAK2(2), TYK2(2) 4776708 15 14 15 6 3 4 4 1 3 0 0.694 1.000 1.000 191 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(9), CDC25B(3), MYT1(7), WEE1(1), YWHAH(1) 6259861 21 20 21 5 3 2 9 6 1 0 0.549 1.000 1.000 192 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(6), JAK2(2), JAK3(3), MAPK1(4), STAT3(3), TYK2(2) 5322868 20 18 16 7 4 3 4 5 4 0 0.637 1.000 1.000 193 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(3), KHK(2), LCT(8), MPI(3), PGM1(3), PYGL(4), PYGM(3), TPI1(2) 6059784 28 26 28 9 7 5 6 5 5 0 0.411 1.000 1.000 194 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), MIOX(2), UGDH(3) 3873966 12 12 12 6 3 1 3 3 2 0 0.824 1.000 1.000 195 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 9 CASP3(1), CASP7(1), GZMB(1), HMGB1(1), HMGB2(1), TOP2A(2), TOP2B(3) 4030067 10 9 10 4 1 3 3 2 1 0 0.804 1.000 1.000 196 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), EPO(2), FLT3(4), IL1A(1), IL3(1), IL9(1), TGFB1(1), TGFB2(2) 3766855 13 11 13 6 4 1 5 2 1 0 0.767 1.000 1.000 197 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(2), HADHA(3), HSD17B4(3), SIRT1(1), SIRT5(1), VNN2(1) 5399408 13 13 13 6 0 3 3 4 3 0 0.881 1.000 1.000 198 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CHPT1(1), ENPP2(6), ENPP6(3), PAFAH2(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(8), PLD2(1), PPAP2B(1) 10583122 40 37 40 9 4 10 11 8 7 0 0.157 1.000 1.000 199 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 AHCY(1), CTH(2), GGT1(1), MARS(2), MARS2(4), MAT1A(1), PAPSS1(3), PAPSS2(3), SEPHS1(1) 5637988 18 17 17 5 4 5 5 3 1 0 0.366 1.000 1.000 200 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(2), IL10RA(3), IL10RB(1), IL1A(1), JAK1(6), STAT1(5), STAT3(3), STAT5A(1) 5548120 22 20 21 8 1 7 6 4 4 0 0.463 1.000 1.000 201 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 GCK(2), HK1(3), HK2(5), HK3(4), IMPA1(1), IMPA2(2), ISYNA1(2), PGM1(3), PGM3(1), TGDS(2) 5308888 25 24 25 9 5 5 8 3 4 0 0.549 1.000 1.000 202 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3) 5540691 18 17 18 7 3 2 4 4 5 0 0.718 1.000 1.000 203 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARS2(2), FARSB(4), GOT1(1), GOT2(2), PAH(4), TAT(1), YARS(3), YARS2(3) 3964861 20 18 20 7 1 7 7 4 1 0 0.472 1.000 1.000 204 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 CDC34(1), NRF1(3), UBE2D2(1), UBE2E1(1), UBE2J1(1), UBE2J2(1), UBE2L3(1), UBE2L6(1), UBE3A(4) 4805613 14 14 14 6 2 5 5 0 2 0 0.778 1.000 1.000 205 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(6), EGFR(14), MAP2K1(4), MAP3K1(3), MAPK14(1), NCOR2(11), RARA(2), RXRA(4), THRA(5), THRB(1) 7874705 51 45 51 12 8 8 18 9 8 0 0.152 1.000 1.000 206 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), IDS(3), IDUA(3), LCT(8), NAGLU(1) 6522401 26 25 26 8 5 6 7 7 1 0 0.431 1.000 1.000 207 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), PER1(5) 3886607 17 17 17 7 3 3 6 4 1 0 0.735 1.000 1.000 208 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 19 AKT1(2), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), MAPK1(4), NFKB1(2), PAK1(1), PIK3R1(6), RAF1(2), RB1(10), RELA(1), TFDP1(2) 7828394 42 40 39 10 6 9 5 7 15 0 0.188 1.000 1.000 209 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), IL4(1), IL4R(2), IRS1(1), JAK1(6), JAK3(3), RPS6KB1(3), SHC1(1), STAT6(2) 6720228 21 20 21 5 4 6 6 3 2 0 0.226 1.000 1.000 210 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(6), ELK1(1), FOS(1), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PDGFRA(6), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(7), STAT1(5), STAT3(3), STAT5A(1) 13760303 64 53 63 12 8 9 24 8 15 0 0.0666 1.000 1.000 211 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2) 6029403 22 19 22 9 3 7 4 4 4 0 0.715 1.000 1.000 212 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARFGAP1(3), ARFGAP3(2), ARFGEF2(5), CLTA(1), COPA(6), GBF1(6), GPLD1(3) 7390021 26 24 26 7 4 7 9 3 3 0 0.318 1.000 1.000 213 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(2), CDO1(1), CTH(2), GOT1(1), GOT2(2), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), SULT1B1(2), SULT1C2(2), SULT4A1(1) 5707741 22 20 22 8 4 3 9 3 3 0 0.650 1.000 1.000 214 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 APP(3), CAPNS1(1), CAPNS2(2), CSNK1A1(1), GSK3B(1), MAPT(6) 4192884 14 13 14 5 2 3 7 1 1 0 0.620 1.000 1.000 215 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(3), ALOX15(1), ALOX5(2), CYP1A2(4), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), RDH11(1), RDH12(3) 10897024 50 42 50 10 7 9 22 7 5 0 0.0534 1.000 1.000 216 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), B4GALT2(3), FBP2(1), G6PC(2), GAA(3), GALK2(1), GALT(1), GANAB(1), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKM(2), PFKP(3), PGM1(3), PGM3(1) 14813090 71 61 71 14 13 17 21 10 10 0 0.0192 1.000 1.000 217 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 19 CSNK2A1(6), FOS(1), JAK2(2), MAP2K1(4), MPL(2), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(7), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4) 11519570 51 45 50 10 6 11 18 6 10 0 0.0658 1.000 1.000 218 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 ACTA1(2), APAF1(9), BCL2(1), CASP3(1), FAS(1), FASLG(1), IL1A(1), MAPKAPK3(2) 5153734 18 17 18 6 3 5 4 5 1 0 0.507 1.000 1.000 219 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(3), IKBKB(5), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), TNFAIP3(3), TRAF3(3), TRAF6(1) 8277422 23 22 23 9 3 5 5 4 6 0 0.699 1.000 1.000 220 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 35 BTK(5), CALM1(1), CALM3(1), ELK1(1), FCER1A(2), FOS(1), LYN(3), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PAK2(5), PIK3R1(6), PLA2G4A(3), PLCG1(5), RAF1(2), SHC1(1), SOS1(7), SYK(2), SYT1(5), VAV1(2) 18404402 89 69 86 17 19 15 28 15 12 0 0.0219 1.000 1.000 221 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 6849510 23 21 23 9 4 5 7 3 4 0 0.721 1.000 1.000 222 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 6849510 23 21 23 9 4 5 7 3 4 0 0.721 1.000 1.000 223 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), SHMT1(1) 6849510 23 21 23 9 4 5 7 3 4 0 0.721 1.000 1.000 224 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX3(1), ELOVL5(1), ELOVL6(1), FADS2(2), FASN(4), HADHA(3), HSD17B12(1), SCD(1) 6543336 14 13 14 6 1 2 5 2 4 0 0.823 1.000 1.000 225 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BET1(1), GOSR1(3), SEC22B(1), SNAP25(1), STX11(3), STX17(1), STX18(2), STX19(1), STX4(4), STX5(1), STX7(2), STX8(2), TSNARE1(1), USE1(1), VAMP1(1), VAMP5(1) 7593036 26 25 26 7 4 7 8 2 5 0 0.302 1.000 1.000 226 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(3), B4GALT2(3), G6PC(2), G6PC2(3), GAA(3), GALK2(1), GALT(1), GANC(3), GCK(2), GLA(3), GLB1(4), HK1(3), HK2(5), HK3(4), LALBA(1), LCT(8), MGAM(18), PFKL(4), PFKM(2), PFKP(3), PGM1(3), PGM3(1), RDH11(1), RDH12(3), UGP2(1) 17569991 87 72 87 17 16 18 29 13 11 0 0.0121 1.000 1.000 227 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 23 CSNK2A1(6), EGF(6), EGFR(14), ELK1(1), FOS(1), JAK1(6), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), PIK3R1(6), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(7), STAT1(5), STAT3(3), STAT5A(1) 14926918 78 64 77 16 9 13 27 13 16 0 0.0599 1.000 1.000 228 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), IDI1(1), LSS(3), PMVK(1) 5046464 14 12 14 9 5 5 2 1 1 0 0.871 1.000 1.000 229 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 23 ATM(9), ATR(18), CCNA1(4), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), DHFR(3), GSK3B(1), RB1(10), SKP2(2), TFDP1(2), TGFB1(1), TGFB2(2) 13105421 64 56 64 14 5 14 15 15 15 0 0.152 1.000 1.000 230 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 33 ADCY1(12), CALM1(1), CALM3(1), CREB1(1), ELK1(1), FOS(1), GNAI1(1), GNAS(6), GNB1(2), MAP2K1(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), RAF1(2), RPS6KA3(3), SYT1(5) 15670785 76 58 76 14 22 14 23 12 5 0 0.00682 1.000 1.000 231 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 21 ADCY1(12), AKT1(2), BAD(1), BAX(1), BCL2(1), BCL2L1(2), CSF2RB(5), IGF1R(7), IL3(1), IL3RA(3), KIT(5), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), YWHAH(1) 8998052 55 46 55 14 10 15 14 11 5 0 0.108 1.000 1.000 232 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKL(4), PFKM(2), PFKP(3), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7) 11046189 48 45 48 12 7 5 18 12 6 0 0.288 1.000 1.000 233 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GCK(2), GFPT1(2), GNE(1), GNPDA1(1), HEXA(3), HK1(3), HK2(5), HK3(4), PGM3(1), RENBP(3), UAP1(2) 7717229 29 28 29 9 7 7 7 4 4 0 0.432 1.000 1.000 234 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA1(4), PSMA2(1), PSMA6(1), PSMB2(1), PSMB4(2), PSMB5(2), PSMB6(1), PSMB7(1), PSMC2(4), PSMC3(1), PSMD1(1), PSMD11(1), PSMD2(3) 7279642 23 23 23 8 2 3 11 4 3 0 0.779 1.000 1.000 235 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(4), EPO(2), HIF1A(2), JAK2(2), NFKB1(2), RELA(1), SOD2(1) 5790559 14 14 14 6 2 5 3 3 1 0 0.672 1.000 1.000 236 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 27 EGFR(14), ELK1(1), GNAS(6), GNB1(2), IGF1R(7), MAP2K1(4), MAP2K2(3), MAPK1(4), MKNK1(1), MKNK2(1), MYC(3), NGFR(1), PDGFRA(6), PTPRR(4), RAF1(2), RPS6KA1(4), RPS6KA5(4), SHC1(1), SOS1(7), SRC(1), STAT3(3) 14045836 79 62 75 17 18 11 29 13 8 0 0.0618 1.000 1.000 237 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR7(1), CD28(2), CXCR3(1), CXCR4(1), IFNG(1), IFNGR1(4), IFNGR2(2), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), IL4(1), IL4R(2), IL5(1), TGFB1(1), TGFB2(2) 9102244 44 37 43 12 7 9 12 8 8 0 0.168 1.000 1.000 238 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 15 ADAM12(6), AGT(2), AGTR2(2), EDNRB(3), EGF(6), EGFR(14), FOS(1), MYC(3), NFKB1(2), PLCG1(5), PRKCA(2), RELA(1) 9172461 47 43 47 13 5 10 19 9 4 0 0.229 1.000 1.000 239 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 15 AKT1(2), CREB1(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NFKB1(2), PIK3R1(6), RB1(10), RELA(1), SP1(1) 7841103 42 39 39 11 8 6 8 5 15 0 0.502 1.000 1.000 240 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 38 CALM1(1), CALM3(1), CD3D(1), ELK1(1), FOS(1), FYN(3), LAT(3), LCK(5), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PIK3R1(6), PLCG1(5), PRKCA(2), PTPN7(2), RAF1(2), RELA(1), SHC1(1), SOS1(7), SYT1(5), VAV1(2), ZAP70(2) 19486584 86 65 86 16 17 16 28 14 11 0 0.0130 1.000 1.000 241 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREB1(1), FOS(1), OPRK1(2), POLR2A(9), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 5865799 21 19 21 9 2 7 9 2 1 0 0.729 1.000 1.000 242 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3D(1), CXCR3(1), ETV5(3), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL18R1(2), JAK2(2), MAP2K6(1), MAPK14(1), MAPK8(4), STAT4(3), TYK2(2) 8497800 36 32 36 10 2 9 14 5 6 0 0.438 1.000 1.000 243 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(1), CREB1(1), CREB5(5), DUSP10(2), EEF2K(4), ELK1(1), IL1R1(2), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K10(4), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK5(1), MKNK1(1), MKNK2(1), MYEF2(3), NFKB1(2), NR2C2(1), TRAF6(1) 15189407 64 53 61 14 11 14 17 13 9 0 0.0695 1.000 1.000 244 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 21 CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CDK4(4), CDK6(1), CDKN1B(2), RB1(10), RBL1(8), TFDP1(2) 7042429 39 37 39 11 3 8 8 7 13 0 0.402 1.000 1.000 245 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(4), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), HAL(2) 8653411 45 40 45 12 8 13 10 12 2 0 0.236 1.000 1.000 246 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(6), ARHGEF1(5), GNA12(1), GNA13(1), GNB1(2), MYLK(4), PLCB1(12), PPP1R12B(1), PRKCA(2), ROCK1(11) 9422362 45 41 45 12 7 10 15 9 4 0 0.349 1.000 1.000 247 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2) 10440262 66 50 66 18 12 16 19 12 7 0 0.144 1.000 1.000 248 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(12), CD3D(1), CREBBP(15), CSK(1), GNAS(6), GNB1(2), HLA-DRA(1), LCK(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTPRC(13), ZAP70(2) 10440262 66 50 66 18 12 16 19 12 7 0 0.144 1.000 1.000 249 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 18 AKT1(2), EIF2B5(2), EIF2S1(1), EIF2S2(3), EIF4EBP1(1), GSK3B(1), IGF1R(7), INPPL1(4), PDPK1(2), PIK3R1(6), PTEN(6), RPS6KB1(3) 7996833 38 33 37 10 6 8 11 4 9 0 0.346 1.000 1.000 250 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTAP(3), MTFMT(3), MTR(4), TAT(1) 9453517 38 31 37 10 7 9 14 5 3 0 0.173 1.000 1.000 251 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 21 AKT1(2), AP2A1(2), AP2M1(3), BAD(1), BTK(5), EEA1(8), GSK3B(1), LYN(3), PDPK1(2), PFKL(4), PFKM(2), PFKP(3), PLCG1(5), PRKCE(2), PRKCZ(3), RAB5A(2), RPS6KB1(3), VAV2(1) 11198108 52 43 52 13 4 15 20 7 6 0 0.134 1.000 1.000 252 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 15 APAF1(9), ATM(9), BAX(1), BCL2(1), CCND1(2), CCNE1(3), CDK4(4), MDM2(2), RB1(10) 7872697 41 35 41 11 3 9 7 10 12 0 0.465 1.000 1.000 253 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 20 AKT1(2), BCL2(1), BCR(1), CRKL(1), FOS(1), JAK2(2), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK8(4), MYC(3), PIK3R1(6), RAF1(2), SOS1(7), STAT1(5), STAT5A(1), STAT5B(4) 11628028 48 42 48 12 5 13 18 4 8 0 0.184 1.000 1.000 254 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(12), GNAS(6), GNB1(2), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 6953378 38 33 38 11 11 6 12 7 2 0 0.411 1.000 1.000 255 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX12(2), ALOX12B(4), ALOX15(1), ALOX15B(2), ALOX5(2), CBR3(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2J2(4), CYP2U1(1), CYP4A11(8), CYP4A22(6), CYP4F2(3), CYP4F3(1), DHRS4(2), EPHX2(4), GGT1(1), GPX2(2), GPX4(2), GPX6(1), GPX7(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5) 17719710 94 74 94 21 13 22 31 14 14 0 0.0190 1.000 1.000 256 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 21 AKT1(2), EIF4A1(1), EIF4EBP1(1), EIF4G1(12), EIF4G2(3), EIF4G3(4), GHR(4), IRS1(1), MAPK1(4), MAPK14(1), MKNK1(1), PDPK1(2), PIK3R1(6), PRKCA(2), PTEN(6), RPS6KB1(3) 11857455 53 43 50 11 3 15 17 7 11 0 0.135 1.000 1.000 257 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 31 ACTA1(2), CRK(1), CRKL(1), DOCK1(8), ELK1(1), FOS(1), GAB1(2), HGF(8), ITGA1(3), MAP2K1(4), MAP2K2(3), MAP4K1(2), MAPK1(4), MAPK8(4), MET(1), PAK1(1), PIK3R1(6), PTEN(6), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAF1(2), RAP1B(2), SOS1(7), SRC(1), STAT3(3) 17162334 82 66 77 20 12 10 29 19 12 0 0.225 1.000 1.000 258 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 11 ADAM17(4), APC(17), AXIN1(5), BTRC(1), CTNNB1(2), DLL1(4), DVL1(2), FZD1(3), GSK3B(1), WNT1(1) 7914816 40 30 40 11 5 10 11 7 6 1 0.409 1.000 1.000 259 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 31 APAF1(9), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), CHUK(3), FADD(1), GAS2(1), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), SPTAN1(11), TNFRSF10A(1), TNFRSF10B(1), TNFRSF25(2), TRAF2(1) 14699598 50 43 50 10 12 11 13 7 7 0 0.0472 1.000 1.000 260 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), G6PD(2), GPI(2), PFKM(2), PFKP(3), PGD(2), PGM1(3), PGM3(1), PRPS1(3), PRPS1L1(4), PRPS2(1), RBKS(2), RPE(1), RPIA(1), TAL1(2), TKT(1) 9302962 36 36 36 11 6 4 13 9 4 0 0.440 1.000 1.000 261 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 32 AKT1(2), BAD(1), BCL2(1), BCL2L1(2), CBL(2), CFLAR(2), CRKL(1), FOS(1), IL2RA(2), IL2RB(3), IRS1(1), JAK1(6), JAK3(3), MAPK1(4), MYC(3), NMI(5), PIK3R1(6), PTPN6(1), RAF1(2), RPS6KB1(3), SHC1(1), SOS1(7), STAT5A(1), STAT5B(4), SYK(2) 15257870 66 56 63 15 12 18 20 9 7 0 0.0286 1.000 1.000 262 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 16 CBL(2), EGF(6), EGFR(14), MAP2K1(4), MAPK1(4), PTPRB(12), RAF1(2), SHC1(1), SOS1(7), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), SRC(1) 10244571 58 52 55 16 9 11 20 11 7 0 0.301 1.000 1.000 263 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 32 BLNK(3), BTK(5), CALM1(1), CALM3(1), ELK1(1), FOS(1), LYN(3), MAP2K1(4), MAP3K1(3), MAPK14(1), MAPK8(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), PLCG1(5), PRKCA(2), RAF1(2), SHC1(1), SOS1(7), SYK(2), SYT1(5), VAV1(2) 17035931 74 59 74 18 15 12 27 12 8 0 0.115 1.000 1.000 264 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(3), CALCR(4), CALCRL(1), CD97(1), CRHR2(4), ELTD1(6), EMR1(5), EMR2(2), GHRHR(2), GIPR(1), GLP1R(1), GLP2R(3), GPR64(5), LPHN1(5), LPHN2(8), LPHN3(14), VIPR2(3) 12129177 68 54 68 20 7 7 24 22 8 0 0.344 1.000 1.000 265 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 188 ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), ARHGAP5(6), BAD(1), BCAR1(2), BCL2(1), BIRC2(1), BIRC3(1), BRAF(4), CAPN2(4), CCND1(2), CDC42(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(9), COL4A6(2), COL5A1(9), COL5A2(12), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), CRK(1), CRKL(1), CTNNB1(2), DIAPH1(6), DOCK1(8), EGF(6), EGFR(14), ELK1(1), ERBB2(8), FARP2(1), FLNA(8), FLNB(4), FLNC(8), FLT1(10), FN1(14), FYN(3), GRLF1(12), GSK3B(1), HGF(8), IBSP(1), IGF1R(7), ILK(4), ITGA1(3), ITGA10(4), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAV(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KDR(5), LAMA1(22), LAMA2(32), LAMA3(7), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), MAP2K1(4), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MET(1), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARVG(2), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(7), PDPK1(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP5K1C(2), PPP1R12A(3), PRKCA(2), PRKCG(7), PTEN(6), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF1(2), RELN(34), RHOA(4), ROCK1(11), ROCK2(5), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(7), SOS2(9), SPP1(1), SRC(1), THBS1(7), THBS2(7), THBS4(5), TLN1(13), TLN2(7), TNC(7), TNN(15), TNR(7), TNXB(10), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), VEGFC(3), VTN(2), VWF(6), ZYX(2) 167019727 871 250 863 269 116 191 303 145 114 2 0.0767 1.000 1.000 266 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 242 ACVR1B(4), ACVR1C(3), AKT1(2), AKT2(3), AKT3(4), ARRB1(2), ARRB2(1), ATF2(1), ATF4(1), BDNF(2), BRAF(4), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(15), CACNA1F(6), CACNA1G(10), CACNA1H(6), CACNA1I(7), CACNA1S(11), CACNA2D1(12), CACNA2D3(2), CACNA2D4(4), CACNB1(5), CACNB2(4), CACNB3(2), CACNB4(1), CACNG1(1), CACNG2(2), CACNG4(2), CACNG5(3), CACNG6(4), CACNG7(1), CACNG8(4), CASP3(1), CD14(1), CDC25B(3), CDC42(1), CHUK(3), CRK(1), CRKL(1), DUSP10(2), DUSP14(1), DUSP16(2), DUSP2(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP6(3), DUSP7(1), DUSP9(1), ECSIT(1), EGF(6), EGFR(14), ELK1(1), ELK4(3), FAS(1), FASLG(1), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(5), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FLNA(8), FLNB(4), FLNC(8), FOS(1), GADD45G(1), GNA12(1), GNG12(1), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAPT(6), MAX(1), MEF2C(7), MKNK1(1), MKNK2(1), MOS(5), MYC(3), NF1(10), NFATC2(6), NFATC4(2), NFKB1(2), NFKB2(1), NLK(1), NRAS(1), NTF3(1), NTRK1(3), NTRK2(1), PAK1(1), PAK2(5), PDGFRA(6), PDGFRB(7), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PPM1A(3), PPP5C(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTPN7(2), PTPRR(4), RAC2(1), RAC3(2), RAF1(2), RAP1B(2), RAPGEF2(2), RASA2(6), RASGRF1(9), RASGRF2(5), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KA6(4), RRAS2(1), SOS1(7), SOS2(9), STK3(1), TAOK1(4), TAOK2(9), TAOK3(2), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1), TRAF6(1), ZAK(2) 127638576 606 235 601 197 113 126 191 101 75 0 0.0726 1.000 1.000 267 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 199 ABI2(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), APC(17), APC2(3), ARHGEF1(5), ARHGEF12(8), ARHGEF4(2), ARHGEF6(3), ARHGEF7(1), ARPC1B(1), ARPC2(2), ARPC4(1), BCAR1(2), BDKRB1(1), BRAF(4), C3orf10(1), CD14(1), CDC42(1), CFL1(2), CHRM2(4), CHRM3(5), CHRM5(1), CRK(1), CRKL(1), CSK(1), CYFIP1(5), CYFIP2(5), DIAPH1(6), DIAPH2(6), DIAPH3(9), DOCK1(8), EGF(6), EGFR(14), F2(2), FGD1(10), FGD3(4), FGF1(2), FGF10(2), FGF12(2), FGF13(2), FGF17(1), FGF19(2), FGF2(1), FGF20(1), FGF21(1), FGF23(5), FGF5(3), FGF6(1), FGF7(1), FGF8(1), FGFR1(1), FGFR2(2), FGFR3(6), FGFR4(3), FN1(14), GIT1(1), GNA12(1), GNA13(1), GNG12(1), GRLF1(12), GSN(5), IQGAP1(6), IQGAP2(4), IQGAP3(7), ITGA1(3), ITGA10(4), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(2), ITGAX(5), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), KRAS(1), LIMK1(5), LIMK2(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MOS(5), MSN(3), MYH10(17), MYH14(3), MYH9(13), MYL7(1), MYL9(2), MYLK(4), MYLK2(2), MYLPF(2), NCKAP1(5), NCKAP1L(5), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDGFRA(6), PDGFRB(7), PFN4(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PPP1R12A(3), PPP1R12B(1), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAF1(2), RHOA(4), ROCK1(11), ROCK2(5), RRAS2(1), SCIN(2), SLC9A1(4), SOS1(7), SOS2(9), SSH1(3), SSH2(4), SSH3(1), TIAM1(7), TIAM2(9), TMSB4Y(1), VAV1(2), VAV2(1), VAV3(1), VCL(6), WASF1(3), WASF2(2), WASL(1) 123541042 601 235 593 206 101 126 188 104 81 1 0.410 1.000 1.000 268 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 166 ADCY1(12), ADCY3(6), ADCY4(6), ADCY7(1), ADCY8(13), ADCY9(4), ADORA2A(1), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), ATP2A1(2), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), ATP2B4(4), AVPR1A(5), AVPR1B(4), BDKRB1(1), BST1(2), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(15), CACNA1F(6), CACNA1G(10), CACNA1H(6), CACNA1I(7), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCKAR(4), CCKBR(3), CD38(2), CHRM2(4), CHRM3(5), CHRM5(1), CHRNA7(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), EDNRB(3), EGFR(14), ERBB2(8), ERBB3(8), ERBB4(15), GNA15(2), GNAL(2), GNAS(6), GRIN2A(14), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), GRPR(1), HRH1(1), HRH2(1), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), LHCGR(2), LTB4R2(1), MYLK(4), MYLK2(2), NOS1(3), NOS3(4), NTSR1(2), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), PDE1A(3), PDE1B(2), PDE1C(9), PDGFRA(6), PDGFRB(7), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), PTGER3(2), PTGFR(2), PTK2B(2), RYR1(16), RYR2(44), RYR3(23), SLC25A6(1), SLC8A1(8), SLC8A2(4), SLC8A3(10), SPHK2(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), TRHR(4), TRPC1(4) 120884599 634 231 633 231 130 136 204 105 58 1 0.154 1.000 1.000 269 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 231 ADCYAP1R1(3), ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), C5AR1(1), CALCR(4), CALCRL(1), CCKAR(4), CCKBR(3), CGA(1), CHRM2(4), CHRM3(5), CHRM5(1), CNR1(3), CRHR2(4), CTSG(1), CYSLTR1(1), CYSLTR2(2), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHB(1), FSHR(5), GABBR1(2), GABBR2(4), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GABRB1(5), GABRB2(7), GABRE(2), GABRG1(4), GABRG2(6), GABRG3(2), GABRP(4), GABRQ(5), GABRR1(2), GABRR2(2), GALR1(2), GALR2(3), GH1(1), GH2(2), GHR(4), GHRHR(2), GHSR(3), GIPR(1), GLP1R(1), GLP2R(3), GLRA1(2), GLRA2(3), GLRA3(2), GLRB(3), GPR156(2), GPR50(1), GPR63(4), GRIA1(9), GRIA2(10), GRIA3(5), GRIA4(7), GRID1(11), GRIK1(4), GRIK2(3), GRIK3(5), GRIK4(4), GRIK5(6), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRIN3A(10), GRM1(16), GRM2(4), GRM3(13), GRM4(2), GRM5(7), GRM6(3), GRM7(8), GRM8(12), GRPR(1), GZMA(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HRH4(3), HTR1A(6), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3), LEP(1), LEPR(11), LHB(1), LHCGR(2), LTB4R(2), LTB4R2(1), MAS1(2), MC2R(6), MC3R(3), MC4R(3), MC5R(5), MCHR1(1), MCHR2(4), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPBWR1(1), NPBWR2(1), NPFFR2(8), NPY1R(5), NPY2R(3), NR3C1(5), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), P2RX1(4), P2RX2(1), P2RX3(1), P2RY1(3), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PARD3(10), PPYR1(1), PRL(3), PRLHR(2), PRLR(4), PRSS3(1), PTGDR(1), PTGER2(4), PTGER3(2), PTGER4(2), PTGFR(2), PTH2R(6), RXFP1(4), RXFP2(4), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TAAR1(2), TAAR2(2), TAAR6(1), TACR1(2), TACR2(2), TACR3(5), TBXA2R(1), THRA(5), THRB(1), TRHR(4), TRPV1(5), TSHR(2), UTS2R(1), VIPR2(3) 98570089 654 224 653 238 107 118 246 119 64 0 0.172 1.000 1.000 270 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTB(2), ACTG1(2), CHAD(3), COL11A1(38), COL11A2(6), COL17A1(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(9), COL4A6(2), COL5A1(9), COL5A2(12), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DES(1), DSC1(1), DSC2(1), DSG1(4), DSG2(2), DSG3(2), DSG4(1), FN1(14), GJA1(1), GJA10(3), GJA3(1), GJA5(2), GJA8(6), GJA9(2), GJB3(1), GJC1(1), GJC3(1), GJD2(1), GJD4(1), IBSP(1), ITGA6(3), ITGB4(3), KRT1(2), KRT10(4), KRT12(3), KRT13(2), KRT14(6), KRT15(1), KRT16(1), KRT18(1), KRT2(3), KRT23(1), KRT24(5), KRT25(5), KRT27(2), KRT28(2), KRT31(3), KRT32(1), KRT33A(1), KRT33B(2), KRT34(3), KRT35(1), KRT36(4), KRT38(5), KRT39(4), KRT4(6), KRT40(2), KRT5(8), KRT6A(2), KRT6B(1), KRT6C(3), KRT7(2), KRT71(1), KRT72(1), KRT73(4), KRT74(2), KRT75(1), KRT76(1), KRT77(2), KRT78(6), KRT79(2), KRT83(3), KRT85(2), KRT86(2), KRT9(2), LAMA1(22), LAMA2(32), LAMA3(7), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), LMNB1(1), LMNB2(4), NES(7), RELN(34), SPP1(1), THBS1(7), THBS2(7), THBS4(5), TNC(7), TNN(15), TNR(7), TNXB(10), VIM(2), VTN(2), VWF(6) 113623912 585 214 585 175 87 117 211 91 78 1 0.0505 1.000 1.000 271 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 120 ABLIM1(4), ABLIM2(3), ABLIM3(2), ARHGEF12(8), CDC42(1), CFL1(2), CXCL12(1), CXCR4(1), DCC(19), DPYSL2(2), DPYSL5(2), EFNA5(2), EFNB1(2), EFNB2(1), EPHA1(6), EPHA3(12), EPHA4(9), EPHA5(12), EPHA6(10), EPHA7(11), EPHA8(3), EPHB1(9), EPHB2(2), EPHB3(5), EPHB4(3), EPHB6(4), FES(4), FYN(3), GNAI1(1), GNAI3(1), GSK3B(1), KRAS(1), L1CAM(3), LIMK1(5), LIMK2(3), MAPK1(4), MET(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NGEF(1), NRAS(1), NRP1(4), NTN1(1), NTNG1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLXNA1(15), PLXNA2(5), PLXNA3(9), PLXNB1(3), PLXNB2(14), PLXNB3(5), PLXNC1(7), PTK2(5), RAC2(1), RAC3(2), RGS3(2), RHOA(4), RHOD(1), ROBO1(7), ROBO2(11), ROBO3(2), ROCK1(11), ROCK2(5), SEMA3A(10), SEMA3B(1), SEMA3C(4), SEMA3D(1), SEMA3E(8), SEMA3F(3), SEMA4A(3), SEMA4B(3), SEMA4C(1), SEMA4D(2), SEMA4F(3), SEMA4G(2), SEMA5B(8), SEMA6A(2), SEMA6B(2), SEMA6C(1), SEMA6D(4), SEMA7A(1), SLIT1(3), SLIT2(15), SLIT3(3), SRGAP1(6), SRGAP2(1), SRGAP3(2), UNC5A(3), UNC5B(4), UNC5C(12), UNC5D(14) 85101463 453 210 444 148 71 102 143 86 51 0 0.117 1.000 1.000 272 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 84 AGRN(2), CD44(1), CHAD(3), COL11A1(38), COL11A2(6), COL1A1(6), COL1A2(13), COL2A1(4), COL3A1(12), COL4A1(6), COL4A2(4), COL4A4(9), COL4A6(2), COL5A1(9), COL5A2(12), COL5A3(6), COL6A1(5), COL6A2(6), COL6A3(13), COL6A6(17), DAG1(1), FN1(14), FNDC1(7), FNDC3A(5), FNDC4(1), FNDC5(1), GP5(3), GP6(1), GP9(1), HMMR(1), HSPG2(11), IBSP(1), ITGA1(3), ITGA10(4), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAV(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), LAMA1(22), LAMA2(32), LAMA3(7), LAMA4(18), LAMA5(9), LAMB1(5), LAMB3(2), LAMB4(11), LAMC1(6), LAMC2(4), LAMC3(5), RELN(34), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SPP1(1), SV2A(3), SV2B(3), SV2C(3), THBS1(7), THBS2(7), THBS4(5), TNC(7), TNN(15), TNR(7), TNXB(10), VTN(2), VWF(6) 101537613 528 205 528 162 76 112 181 93 66 0 0.118 1.000 1.000 273 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 138 ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), ADRA1A(4), ADRA1B(1), ADRB1(1), ADRB3(2), ANXA6(4), ARRB1(2), ARRB2(1), ATP1A4(4), ATP1B3(3), ATP2A2(4), ATP2A3(3), ATP2B1(3), ATP2B2(2), ATP2B3(8), CACNA1A(7), CACNA1B(4), CACNA1C(11), CACNA1D(15), CACNA1E(15), CACNA1S(11), CACNB1(5), CACNB3(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CASQ1(1), CASQ2(2), CHRM2(4), CHRM3(5), CHRM5(1), GJA1(1), GJA5(2), GJB3(1), GNAI3(1), GNAO1(2), GNAZ(3), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), ITPR1(8), ITPR2(11), ITPR3(5), KCNB1(3), KCNJ3(4), KCNJ5(3), MIB1(5), NME7(2), PEA15(1), PKIG(1), PLCB3(5), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SLC8A3(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1) 84204815 464 201 462 166 95 105 132 80 51 1 0.226 1.000 1.000 274 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), AKT1(2), AKT2(3), AKT3(4), AMOTL1(2), ASH1L(10), CASK(1), CDC42(1), CDK4(4), CGN(2), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CRB3(2), CSDA(1), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTTN(4), EPB41L1(5), EPB41L2(7), EPB41L3(16), EXOC3(1), EXOC4(10), F11R(1), GNAI1(1), GNAI3(1), HCLS1(2), IGSF5(3), INADL(7), KRAS(1), LLGL2(3), MAGI1(3), MAGI2(10), MAGI3(6), MLLT4(4), MPDZ(8), MPP5(5), MYH1(11), MYH10(17), MYH11(11), MYH13(16), MYH14(3), MYH15(9), MYH2(16), MYH3(8), MYH4(13), MYH6(10), MYH7(9), MYH7B(4), MYH8(18), MYH9(13), MYL7(1), MYL9(2), MYLPF(2), NRAS(1), PARD3(10), PARD6A(1), PARD6B(1), PARD6G(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PPP2R3A(5), PPP2R3B(3), PPP2R4(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PTEN(6), RAB13(1), RHOA(4), RRAS2(1), SPTAN1(11), SRC(1), SYMPK(4), TJAP1(1), TJP1(9), TJP2(4), TJP3(5), VAPA(1), YES1(1), ZAK(2) 88086992 482 199 478 153 76 108 165 75 56 2 0.143 1.000 1.000 275 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ACTA1(2), ACTA2(1), ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), ARRB1(2), ARRB2(1), ATF1(2), ATF2(1), ATF4(1), ATF5(2), ATP2A2(4), ATP2A3(3), CACNB3(2), CALCA(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CNN1(1), CNN2(1), CORIN(2), DGKZ(4), ETS2(5), FOS(1), GABPA(2), GBA2(3), GJA1(1), GNB1(2), GNB2(3), GNB3(3), GNB4(1), GNB5(1), GNG12(1), GNG2(1), GRK5(5), GSTO1(2), GUCY1A3(4), IGFBP1(2), IGFBP3(1), IGFBP4(1), IL1B(1), ITPR1(8), ITPR2(11), ITPR3(5), MIB1(5), MYLK2(2), NFKB1(2), NOS1(3), NOS3(4), OXTR(2), PDE4B(4), PDE4D(5), PKIG(1), PLCB3(5), PLCD1(2), PLCG1(5), PLCG2(4), PRKACA(4), PRKACB(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), RGS1(3), RGS11(1), RGS14(1), RGS16(1), RGS17(5), RGS18(1), RGS19(1), RGS2(1), RGS20(2), RGS3(2), RGS4(1), RGS5(1), RGS6(5), RGS7(13), RGS9(5), RYR1(16), RYR2(44), RYR3(23), SFN(5), SLC8A1(8), SP1(1), TNXB(10), USP5(4), YWHAB(1), YWHAH(1), YWHAQ(1) 77731935 393 188 392 129 74 98 107 68 45 1 0.111 1.000 1.000 276 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 140 ADA(1), ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), ADK(1), ADSL(4), ADSS(2), ADSSL1(2), AK1(1), AK2(1), AK3L1(1), AK5(5), AK7(2), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), ATIC(2), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), ENTPD8(1), GART(3), GDA(4), GMPR2(1), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(6), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NME7(2), NPR1(1), NPR2(5), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), NUDT5(1), NUDT9(1), PAPSS1(3), PAPSS2(3), PDE10A(12), PDE11A(2), PDE1A(3), PDE1C(9), PDE2A(1), PDE3B(1), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE7A(3), PDE8B(7), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), PNPT1(4), POLA1(2), POLA2(2), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), PPAT(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), XDH(3) 72982877 333 183 332 106 59 68 112 52 42 0 0.261 1.000 1.000 277 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTA1(2), ACTA2(1), ACTN2(6), ACTN3(6), ACTN4(3), DES(1), DMD(33), FAM48A(2), MYBPC1(11), MYBPC2(3), MYBPC3(3), MYH3(8), MYH6(10), MYH7(9), MYH8(18), MYL1(1), MYL9(2), MYOM1(10), NEB(26), TNNI2(1), TNNI3(1), TNNT1(2), TNNT3(1), TPM1(1), TTN(247), VIM(2) 62136330 410 180 408 108 44 96 161 61 45 3 0.179 1.000 1.000 278 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 249 ACVR1(5), ACVR1B(4), ACVR2A(1), AMHR2(1), BMP2(3), BMP7(3), BMPR1B(1), BMPR2(3), CCL1(3), CCL15(1), CCL2(2), CCL20(1), CCL23(2), CCL25(2), CCL28(1), CCL3(1), CCL7(1), CCL8(2), CCR1(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CD27(2), CD40(4), CD40LG(3), CSF1(1), CSF2RA(1), CSF2RB(5), CSF3R(2), CX3CL1(1), CX3CR1(1), CXCL1(1), CXCL10(2), CXCL12(1), CXCL13(1), CXCL2(1), CXCL3(1), CXCL9(2), CXCR3(1), CXCR4(1), EDA(4), EDAR(1), EGF(6), EGFR(14), EPO(2), FAS(1), FASLG(1), FLT1(10), FLT3(4), FLT3LG(1), FLT4(6), GDF5(3), GH1(1), GH2(2), GHR(4), HGF(8), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(4), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL17A(1), IL17RA(2), IL17RB(1), IL18R1(2), IL18RAP(2), IL19(2), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL1RAP(4), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL25(1), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), INHBA(1), INHBB(2), INHBC(3), INHBE(1), KDR(5), KIT(5), LEP(1), LEPR(11), LIF(2), LIFR(9), LTA(1), LTBR(2), MET(1), MPL(2), NGFR(1), OSMR(3), PDGFC(1), PDGFRA(6), PDGFRB(7), PF4V1(1), PLEKHO2(2), PPBP(2), PRL(3), PRLR(4), RELT(3), TGFB1(1), TGFB2(2), TGFBR1(1), TNFRSF10A(1), TNFRSF10B(1), TNFRSF11A(2), TNFRSF11B(2), TNFRSF13B(2), TNFRSF13C(2), TNFRSF19(3), TNFRSF21(2), TNFRSF25(2), TNFRSF4(2), TNFRSF6B(2), TNFRSF9(1), TNFSF11(1), TNFSF13(1), TNFSF13B(1), TNFSF14(2), TNFSF18(1), TNFSF4(2), TNFSF8(2), TPO(10), VEGFC(3), XCL1(1), XCL2(1), XCR1(2) 80162356 379 174 375 128 56 75 136 71 41 0 0.368 1.000 1.000 279 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 141 APC(17), APC2(3), AXIN1(5), AXIN2(5), BTRC(1), CACYBP(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CCND1(2), CHD8(7), CREBBP(15), CSNK1A1(1), CSNK1E(3), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTBP1(1), CTBP2(2), CTNNB1(2), CUL1(6), CXXC4(1), DAAM1(7), DAAM2(6), DKK1(2), DKK2(3), DVL1(2), DVL2(1), DVL3(4), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LEF1(2), LRP5(3), LRP6(12), MAP3K7(4), MAPK10(3), MAPK8(4), MAPK9(4), MMP7(1), MYC(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKD1(5), NKD2(1), NLK(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PORCN(2), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRICKLE1(5), PRICKLE2(4), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAC2(1), RAC3(2), RBX1(2), RHOA(4), ROCK1(11), ROCK2(5), SENP2(2), SFRP1(1), SFRP4(8), SFRP5(1), SIAH1(1), SKP1(1), SMAD2(3), SMAD3(2), SMAD4(8), SOX17(1), TBL1X(4), TBL1XR1(3), TBL1Y(2), TCF7(1), TCF7L1(1), VANGL1(1), VANGL2(2), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1) 70764443 358 173 355 113 61 80 120 50 46 1 0.0824 1.000 1.000 280 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(11), ACACB(12), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), CALM1(1), CALM3(1), CBL(2), CBLB(2), CRK(1), CRKL(1), EIF4EBP1(1), ELK1(1), FASN(4), FBP2(1), FLOT1(1), FLOT2(3), FOXO1(3), G6PC(2), G6PC2(3), GCK(2), GSK3B(1), GYS1(5), GYS2(5), IKBKB(5), INPP5D(7), INSR(2), IRS1(1), IRS2(2), IRS4(9), KRAS(1), LIPE(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MKNK1(1), MKNK2(1), NRAS(1), PCK2(2), PDE3A(12), PDE3B(1), PDPK1(2), PFKL(4), PFKM(2), PFKP(3), PHKA1(1), PHKA2(9), PHKB(2), PHKG2(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PKLR(1), PKM2(3), PPARGC1A(3), PPP1R3A(7), PPP1R3B(3), PPP1R3C(1), PPP1R3D(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKACA(4), PRKACB(2), PRKACG(1), PRKAG2(2), PRKAG3(2), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCI(2), PRKCZ(3), PRKX(1), PTPN1(2), PTPRF(10), PYGB(3), PYGL(4), PYGM(3), RAF1(2), RAPGEF1(2), RHOQ(1), RPS6KB1(3), RPS6KB2(1), SH2B2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SLC2A4(1), SOCS4(1), SORBS1(2), SOS1(7), SOS2(9), SREBF1(3), TRIP10(5), TSC1(2), TSC2(3) 71724310 330 173 327 103 70 64 106 58 31 1 0.122 1.000 1.000 281 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 160 ADORA1(4), ADORA2A(1), ADORA3(2), ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), AGTR2(2), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCBP2(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CCRL1(1), CCRL2(1), CHML(3), CHRM2(4), CHRM3(5), CHRM5(1), CMKLR1(4), CNR1(3), CX3CR1(1), CXCR3(1), CXCR4(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), EDNRB(3), F2RL1(1), F2RL2(1), F2RL3(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR17(1), GPR174(2), GPR27(2), GPR3(2), GPR37(5), GPR37L1(2), GPR50(1), GPR6(4), GPR63(4), GPR77(2), GRPR(1), HCRTR1(2), HCRTR2(5), HRH1(1), HRH2(1), HRH3(1), HTR1A(6), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3), LHCGR(2), LTB4R(2), MAS1(2), MC3R(3), MC4R(3), MC5R(5), MLNR(2), MTNR1A(2), MTNR1B(2), NMBR(2), NMUR1(3), NMUR2(1), NPY1R(5), NPY2R(3), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OR10A5(2), OR11A1(1), OR12D3(2), OR1C1(3), OR1Q1(2), OR2H1(3), OR5V1(4), OR7A5(3), OR8B8(1), OXTR(2), P2RY1(3), P2RY10(5), P2RY13(2), P2RY2(2), P2RY6(2), PPYR1(1), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), RGR(3), RHO(3), RRH(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), SUCNR1(1), TBXA2R(1), TRHR(4) 54565865 315 172 314 132 59 57 125 52 22 0 0.502 1.000 1.000 282 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 127 ALCAM(3), CADM1(2), CADM3(1), CD2(1), CD22(1), CD226(3), CD28(2), CD34(4), CD40(4), CD40LG(3), CD58(1), CD6(1), CD80(5), CD86(1), CD8A(2), CD8B(1), CDH1(4), CDH15(2), CDH2(5), CDH3(6), CDH4(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CNTN1(7), CNTN2(4), CNTNAP1(6), CNTNAP2(21), CTLA4(1), ESAM(1), F11R(1), GLG1(3), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(2), ICAM1(2), ICAM2(2), ICAM3(1), ICOS(1), ITGA4(6), ITGA6(3), ITGA8(13), ITGA9(1), ITGAL(2), ITGAM(3), ITGAV(2), ITGB2(2), ITGB7(1), ITGB8(3), L1CAM(3), MAG(1), MPZL1(2), NCAM1(1), NCAM2(7), NEGR1(2), NEO1(1), NFASC(3), NLGN1(12), NLGN2(3), NRCAM(9), NRXN1(20), NRXN2(9), NRXN3(14), PDCD1(1), PTPRC(13), PTPRF(10), PTPRM(14), PVR(2), PVRL2(3), PVRL3(4), SDC1(2), SDC2(2), SDC3(1), SDC4(1), SELE(4), SELL(2), SELP(11), SIGLEC1(11), SPN(2), VCAM1(3), VCAN(15) 65774616 356 171 356 137 63 62 117 63 50 1 0.661 1.000 1.000 283 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 90 ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), ADRB1(1), DRD1(1), DRD2(2), EGF(6), EGFR(14), GJA1(1), GJD2(1), GNAI1(1), GNAI3(1), GNAS(6), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(6), HTR2A(3), HTR2B(1), HTR2C(1), ITPR1(8), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K5(2), MAPK1(4), MAPK7(1), NPR1(1), NPR2(5), NRAS(1), PDGFC(1), PDGFD(4), PDGFRA(6), PDGFRB(7), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), PRKX(1), RAF1(2), SOS1(7), SOS2(9), SRC(1), TJP1(9), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1) 58867559 318 171 314 99 60 68 104 54 32 0 0.0555 1.000 1.000 284 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 149 AKT1(2), AKT2(3), AKT3(4), BCL2L1(2), CBL(2), CBLB(2), CCND1(2), CISH(1), CREBBP(15), CSF2RA(1), CSF2RB(5), CSF3R(2), EPO(2), GH1(1), GH2(2), GHR(4), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(4), IFNGR2(2), IFNK(1), IFNW1(1), IL10RA(3), IL10RB(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), IL13(1), IL13RA1(1), IL13RA2(1), IL19(2), IL21R(1), IL22(1), IL22RA1(2), IL23R(1), IL24(2), IL26(2), IL28A(1), IL28B(1), IL28RA(1), IL2RA(2), IL2RB(3), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL6ST(2), IL7R(3), IL9(1), IL9R(4), IRF9(2), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), LIF(2), LIFR(9), MPL(2), MYC(3), OSMR(3), PIAS2(1), PIAS3(3), PIAS4(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIM1(2), PRL(3), PRLR(4), PTPN11(1), PTPN6(1), SOCS4(1), SOCS5(5), SOCS7(2), SOS1(7), SOS2(9), SPRED1(2), SPRED2(1), SPRY1(1), SPRY2(2), SPRY3(1), SPRY4(1), STAM(2), STAM2(2), STAT1(5), STAT2(3), STAT3(3), STAT4(3), STAT5A(1), STAT5B(4), STAT6(2), TPO(10), TYK2(2) 62996130 298 170 295 100 35 72 94 63 33 1 0.371 1.000 1.000 285 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 72 ACP1(1), ACTB(2), ACTG1(2), ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ACVR1B(4), ACVR1C(3), CDC42(1), CDH1(4), CREBBP(15), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), EGFR(14), ERBB2(8), FARP2(1), FER(2), FGFR1(1), FYN(3), IGF1R(7), INSR(2), IQGAP1(6), LEF1(2), LMO7(6), MAP3K7(4), MAPK1(4), MET(1), MLLT4(4), NLK(1), PARD3(10), PTPN1(2), PTPN6(1), PTPRB(12), PTPRF(10), PTPRJ(6), PTPRM(14), PVRL2(3), PVRL3(4), PVRL4(2), RAC2(1), RAC3(2), RHOA(4), SMAD2(3), SMAD3(2), SMAD4(8), SNAI2(1), SORBS1(2), SRC(1), SSX2IP(2), TCF7(1), TCF7L1(1), TGFBR1(1), TJP1(9), VCL(6), WASF1(3), WASF2(2), WASF3(2), WASL(1), YES1(1) 51543760 277 165 270 82 39 63 86 52 36 1 0.141 1.000 1.000 286 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 93 ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), ATF4(1), CACNA1C(11), CACNA1D(15), CACNA1F(6), CACNA1S(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CDC42(1), CGA(1), EGFR(14), ELK1(1), FSHB(1), GNAS(6), ITPR1(8), ITPR2(11), ITPR3(5), KRAS(1), LHB(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K3(1), MAP3K4(5), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK7(1), MAPK8(4), MAPK9(4), MMP14(2), MMP2(2), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLD1(8), PLD2(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCD(4), PRKX(1), PTK2B(2), RAF1(2), SOS1(7), SOS2(9), SRC(1) 56463296 284 161 281 83 52 63 84 52 33 0 0.0293 1.000 1.000 287 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(5), AMY2A(2), AMY2B(6), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHX58(2), ENPP1(5), ENPP3(5), ENTPD7(3), EP400(7), ERCC2(2), ERCC3(4), G6PC(2), G6PC2(3), GAA(3), GANC(3), GBA(2), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), IFIH1(5), MGAM(18), MOV10L1(2), NUDT5(1), NUDT8(1), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(9), SI(39), SKIV2L2(3), SMARCA2(8), SMARCA5(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4), UXS1(2) 56297057 286 159 285 88 31 55 108 59 33 0 0.506 1.000 1.000 288 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 109 ADA(1), ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADK(1), ADSL(4), ADSS(2), AK1(1), AK2(1), AK5(5), ALLC(1), AMPD1(2), AMPD2(2), AMPD3(1), ATIC(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), CANT1(1), DCK(2), ENPP1(5), ENPP3(5), ENTPD1(2), GART(3), GDA(4), GMPS(4), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(6), HPRT1(1), IMPDH1(3), IMPDH2(1), ITPA(3), NPR1(1), NPR2(5), NUDT2(1), PAPSS1(3), PAPSS2(3), PDE1A(3), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE5A(7), PDE6C(2), PDE9A(2), PFAS(12), PKLR(1), PKM2(3), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), PPAT(2), PRPS1(3), PRPS1L1(4), PRPS2(1), RRM1(1), RRM2(1) 57387511 263 159 262 80 46 52 93 39 33 0 0.131 1.000 1.000 289 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 90 ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), AKAP1(5), AKAP10(3), AKAP11(6), AKAP12(10), AKAP2(1), AKAP3(5), AKAP4(5), AKAP5(2), AKAP6(14), AKAP7(1), AKAP8(2), AKAP9(20), ARHGEF1(5), CALM1(1), CALM3(1), CHMP1B(2), GNA12(1), GNA13(1), GNA15(2), GNAI3(1), GNAL(2), GNAO1(2), GNAZ(3), GNB1(2), GNB2(3), GNB3(3), GNB5(1), GNG12(1), ITPR1(8), KCNJ3(4), KRAS(1), NRAS(1), PDE1A(3), PDE1B(2), PDE1C(9), PDE4A(3), PDE4B(4), PDE4C(2), PDE4D(5), PDE7A(3), PDE8B(7), PLCB3(5), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKD3(9), RHOA(4), SLC9A1(4), USP5(4) 51951630 283 158 279 78 60 60 75 47 41 0 0.0349 1.000 1.000 290 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 83 ABL2(7), AKT1(2), AKT2(3), AKT3(4), BAD(1), BRAF(4), BTC(2), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CBL(2), CBLB(2), CDKN1B(2), CRK(1), CRKL(1), EGF(6), EGFR(14), EIF4EBP1(1), ELK1(1), ERBB2(8), ERBB3(8), ERBB4(15), GAB1(2), GSK3B(1), KRAS(1), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK9(4), MYC(3), NCK1(4), NCK2(3), NRAS(1), NRG1(1), NRG2(4), NRG3(8), NRG4(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), RAF1(2), RPS6KB1(3), RPS6KB2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(7), SOS2(9), SRC(1), STAT5A(1), STAT5B(4) 45681117 255 156 251 82 35 57 89 46 27 1 0.356 1.000 1.000 291 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 72 CALM1(1), CALM3(1), CDIPT(1), CDS1(1), CDS2(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPP5D(7), INPPL1(4), ITPK1(2), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), OCRL(4), PI4KA(5), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3C3(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PIP4K2B(3), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PRKCA(2), PRKCG(7), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(5) 55603636 269 154 268 83 39 55 80 54 40 1 0.117 1.000 1.000 292 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 107 ACTN1(2), ACTN2(6), ACTN3(6), ACTN4(3), ARHGAP5(6), BCAR1(2), CDC42(1), CDH5(4), CLDN10(2), CLDN15(2), CLDN16(1), CLDN18(3), CLDN2(2), CLDN22(1), CLDN23(1), CLDN6(1), CLDN9(1), CTNNA1(5), CTNNA2(19), CTNNA3(6), CTNNB1(2), CTNND1(4), CXCL12(1), CXCR4(1), CYBB(1), ESAM(1), F11R(1), GNAI1(1), GNAI3(1), GRLF1(12), ICAM1(2), ITGA4(6), ITGAL(2), ITGAM(3), ITGB2(2), ITK(1), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MLLT4(4), MMP2(2), MSN(3), MYL7(1), MYL9(2), MYLPF(2), NCF2(4), NCF4(1), NOX1(5), NOX3(4), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTK2(5), PTK2B(2), PTPN11(1), PXN(1), RAC2(1), RAP1B(2), RAPGEF3(5), RASSF5(1), RHOA(4), ROCK1(11), ROCK2(5), SIPA1(1), THY1(1), TXK(3), VASP(1), VAV1(2), VAV2(1), VAV3(1), VCAM1(3), VCL(6) 54644192 258 152 254 105 32 47 87 54 36 2 0.945 1.000 1.000 293 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 81 ACVR1(5), ACVR1B(4), ACVRL1(3), AKT1(2), AURKB(3), BMPR2(3), BUB1(2), CDIPT(1), CDKL1(1), CDKL2(1), CDS1(1), CDS2(3), CLK1(3), CLK2(5), COL4A3BP(4), CSNK2A1(6), CSNK2A2(1), CSNK2B(2), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(4), MAP3K10(4), MOS(5), NEK1(4), NEK3(1), OCRL(4), PAK4(1), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4), PLK3(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), PRKCZ(3), PRKD1(10), PRKG1(3), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KB1(3), STK11(3), TGFBR1(1), VRK1(1) 50362156 268 152 266 78 55 48 78 50 36 1 0.0881 1.000 1.000 294 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 106 ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), ATM(9), ATR(18), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CDC14A(2), CDC16(1), CDC20(2), CDC23(1), CDC25B(3), CDC27(3), CDC6(2), CDC7(1), CDK4(4), CDK6(1), CDKN1B(2), CHEK2(4), CREBBP(15), CUL1(6), E2F2(3), ESPL1(9), FZR1(2), GADD45G(1), GSK3B(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PKMYT1(1), PLK1(2), PRKDC(15), RB1(10), RBL1(8), RBL2(3), RBX1(2), SFN(5), SKP1(1), SKP2(2), SMAD2(3), SMAD3(2), SMAD4(8), SMC1A(3), SMC1B(5), TFDP1(2), TGFB1(1), TGFB2(2), WEE1(1), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 59056609 242 148 242 74 26 57 66 51 42 0 0.335 1.000 1.000 295 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 96 ADCY1(12), ADCY3(6), ADCY4(6), ADCY5(4), ADCY6(4), ADCY7(1), ADCY8(13), ADCY9(4), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREB1(1), CREB3L1(2), CREB3L2(2), CREB3L3(3), CREB3L4(1), CREBBP(15), CTNNB1(2), DCT(1), DVL1(2), DVL2(1), DVL3(4), EDNRB(3), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD4(1), FZD5(1), FZD6(2), FZD8(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GSK3B(1), KIT(5), KRAS(1), LEF1(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MITF(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), POMC(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), TCF7(1), TCF7L1(1), TYR(4), TYRP1(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1) 46091683 227 145 224 75 53 40 71 41 21 1 0.146 1.000 1.000 296 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 65 ADCY1(12), ADCY8(13), ATF4(1), BRAF(4), CACNA1C(11), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CREBBP(15), GRIA1(9), GRIA2(10), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), GRM1(16), GRM5(7), ITPR1(8), ITPR2(11), ITPR3(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), NRAS(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP1R12A(3), PPP1R1A(1), PRKACA(4), PRKACB(2), PRKACG(1), PRKCA(2), PRKCG(7), PRKX(1), RAF1(2), RAP1B(2), RAPGEF3(5), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4) 42697829 254 144 251 83 43 58 80 49 24 0 0.150 1.000 1.000 297 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 88 AKT1(2), AKT3(4), BCAR1(2), CAPN10(3), CAPN11(1), CAPN2(4), CAPN3(3), CAPN6(3), CAPN7(1), CAPN9(3), CAPNS1(1), CDC42(1), CRK(1), CSK(1), DOCK1(8), FYN(3), GIT2(1), ILK(4), ITGA10(4), ITGA11(5), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGAD(3), ITGAE(3), ITGAL(2), ITGAM(3), ITGAV(2), ITGAX(5), ITGB2(2), ITGB3(5), ITGB4(3), ITGB5(1), ITGB6(4), ITGB7(1), ITGB8(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAPK10(3), MAPK12(1), MAPK4(6), MAPK6(3), MAPK7(1), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PDPK1(2), PIK3R2(3), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAP1B(2), RAPGEF1(2), RHO(3), ROCK1(11), ROCK2(5), SDCCAG8(3), SHC1(1), SHC3(3), SORBS1(2), SOS1(7), SRC(1), TLN1(13), TNS1(5), VASP(1), VAV2(1), VAV3(1), VCL(6), ZYX(2) 60052477 252 143 251 85 34 58 90 36 34 0 0.337 1.000 1.000 298 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 90 AKT1(2), AKT2(3), AKT3(4), BCL10(1), CARD11(4), CBL(2), CBLB(2), CD247(1), CD28(2), CD3D(1), CD40LG(3), CD8A(2), CD8B(1), CDC42(1), CDK4(4), CHUK(3), CTLA4(1), FOS(1), FYN(3), GRAP2(1), ICOS(1), IFNG(1), IKBKB(5), IL4(1), IL5(1), ITK(1), KRAS(1), LAT(3), LCK(5), LCP2(1), MALT1(3), MAP3K14(2), MAP3K8(1), NCK1(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDCD1(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PRKCQ(5), PTPN6(1), PTPRC(13), RASGRP1(5), RHOA(4), SOS1(7), SOS2(9), TEC(2), VAV1(2), VAV2(1), VAV3(1), ZAP70(2) 45123169 216 142 213 70 34 47 62 40 32 1 0.362 1.000 1.000 299 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 76 ACTN1(2), ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGEF6(3), ARHGEF7(1), BCAR1(2), BRAF(4), CDC42(1), CRK(1), CSE1L(2), DOCK1(8), EPHB2(2), FYN(3), GRB7(2), GRLF1(12), ILK(4), ITGA1(3), ITGA10(4), ITGA11(5), ITGA2(4), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGA7(5), ITGA8(13), ITGA9(1), ITGB3BP(1), MAP2K4(1), MAP3K11(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MYLK(4), MYLK2(2), P4HB(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PIK3CB(5), PKLR(1), PLCG1(5), PLCG2(4), PTEN(6), PTK2(5), RAF1(2), RHO(3), ROCK1(11), ROCK2(5), SHC1(1), SOS1(7), SOS2(9), SRC(1), TLN1(13), TLN2(7), VASP(1), ZYX(2) 54458645 248 141 244 75 34 47 94 38 35 0 0.241 1.000 1.000 300 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 86 ACVR1(5), ACVR1B(4), ACVR1C(3), ACVR2A(1), ACVRL1(3), AMHR2(1), BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BMPR1B(1), BMPR2(3), CHRD(6), CREBBP(15), CUL1(6), DCN(2), E2F4(1), E2F5(4), FST(1), GDF5(3), GDF6(1), ID1(1), ID3(1), IFNG(1), INHBA(1), INHBB(2), INHBC(3), INHBE(1), LEFTY1(1), LEFTY2(1), LTBP1(16), MAPK1(4), MYC(3), PITX2(1), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), RBL1(8), RBL2(3), RBX1(2), RHOA(4), ROCK1(11), ROCK2(5), RPS6KB1(3), RPS6KB2(1), SKP1(1), SMAD1(2), SMAD2(3), SMAD3(2), SMAD4(8), SMAD5(2), SMAD9(2), SMURF1(2), SMURF2(4), SP1(1), TFDP1(2), TGFB1(1), TGFB2(2), TGFBR1(1), THBS1(7), THBS2(7), THBS4(5), ZFYVE16(3), ZFYVE9(5) 42324429 218 139 212 43 25 46 70 39 38 0 0.000440 1.000 1.000 301 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 121 BID(2), BRAF(4), CASP3(1), CD247(1), CD48(1), FAS(1), FASLG(1), FCGR3A(4), FCGR3B(3), FYN(3), GZMB(1), HLA-C(3), ICAM1(2), ICAM2(2), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IFNG(1), IFNGR1(4), IFNGR2(2), ITGAL(2), ITGB2(2), KIR2DL1(3), KIR2DL3(1), KIR3DL1(7), KLRC2(1), KLRC3(2), KRAS(1), LAT(3), LCK(5), LCP2(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MICB(3), NCR1(5), NCR2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NRAS(1), PAK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG1(5), PLCG2(4), PRF1(3), PRKCA(2), PRKCG(7), PTK2B(2), PTPN11(1), PTPN6(1), RAC2(1), RAC3(2), RAF1(2), SH2D1A(4), SH2D1B(2), SH3BP2(1), SHC1(1), SHC2(3), SHC3(3), SHC4(3), SOS1(7), SOS2(9), SYK(2), TNFRSF10A(1), TNFRSF10B(1), ULBP1(1), ULBP2(1), VAV1(2), VAV2(1), VAV3(1), ZAP70(2) 49658192 234 139 229 88 48 43 68 45 28 2 0.648 1.000 1.000 302 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 72 BRAF(4), C7orf16(1), CACNA1A(7), GNA12(1), GNA13(1), GNAI1(1), GNAI3(1), GNAO1(2), GNAS(6), GNAZ(3), GRIA1(9), GRIA2(10), GRIA3(5), GRM1(16), GRM5(7), GUCY1A2(5), GUCY1A3(4), GUCY1B3(4), GUCY2C(4), GUCY2D(5), GUCY2F(6), IGF1R(7), ITPR1(8), ITPR2(11), ITPR3(5), KRAS(1), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NOS1(3), NOS3(4), NPR1(1), NPR2(5), NRAS(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PPP2CB(1), PPP2R1A(3), PPP2R1B(3), PPP2R2B(3), PRKCA(2), PRKCG(7), PRKG1(3), PRKG2(1), RAF1(2), RYR1(16) 48844601 242 136 238 81 44 50 81 46 21 0 0.327 1.000 1.000 303 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 108 A4GNT(4), ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG6(2), ALG9(1), B3GNT1(1), B3GNT2(1), B3GNT6(1), B3GNT7(1), B4GALT2(3), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), CHPF(4), CHST1(3), CHST11(3), CHST12(1), CHST13(3), CHST14(1), CHST2(2), CHST4(3), CHST6(6), CHSY1(2), DPAGT1(1), EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), FUT8(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(4), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GANAB(1), GCNT1(1), GCNT4(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(3), MGAT5(1), MGAT5B(2), NDST1(1), NDST2(2), NDST3(4), NDST4(7), OGT(3), RPN1(1), RPN2(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST6GALNAC1(4), STT3B(2), UST(1), WBSCR17(8), XYLT1(7), XYLT2(3) 50282171 217 133 217 90 45 32 78 32 30 0 0.907 1.000 1.000 304 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(6), ABCA10(12), ABCA12(12), ABCA13(24), ABCA2(8), ABCA3(4), ABCA4(9), ABCA5(3), ABCA6(7), ABCA7(5), ABCA8(5), ABCA9(7), ABCB1(11), ABCB11(6), ABCB4(9), ABCB5(5), ABCB6(5), ABCB7(4), ABCB8(3), ABCC10(5), ABCC11(4), ABCC12(5), ABCC2(4), ABCC3(3), ABCC5(4), ABCC6(2), ABCC8(11), ABCC9(16), ABCD1(2), ABCD2(6), ABCD3(3), ABCD4(3), ABCG1(3), ABCG2(2), ABCG4(4), ABCG8(8), CFTR(7), TAP1(3), TAP2(5) 53812685 245 133 244 79 32 59 78 39 37 0 0.120 1.000 1.000 305 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 95 AKT1(2), AKT2(3), AKT3(4), CCL3(1), CD14(1), CD40(4), CD80(5), CD86(1), CHUK(3), CXCL10(2), CXCL9(2), FADD(1), FOS(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNAR1(2), IFNAR2(1), IKBKB(5), IKBKE(1), IL12A(1), IL12B(4), IL1B(1), IRAK1(1), IRAK4(3), IRF3(1), IRF5(1), IRF7(2), LBP(7), LY96(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K7(4), MAP3K8(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), RELA(1), RIPK1(2), SPP1(1), STAT1(5), TBK1(1), TICAM1(4), TLR1(1), TLR2(1), TLR3(1), TLR4(7), TLR5(1), TLR6(3), TLR7(4), TLR8(2), TLR9(2), TRAF3(3), TRAF6(1) 39183290 185 130 182 56 31 37 60 33 23 1 0.179 1.000 1.000 306 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 53 ASH1L(10), ASH2L(2), C17orf79(1), CARM1(3), CTCFL(1), DOT1L(3), EED(2), EHMT1(6), EHMT2(6), EZH1(3), EZH2(1), FBXO11(6), HCFC1(6), JMJD4(2), JMJD6(2), KDM6A(8), MEN1(2), MLL(15), MLL3(24), MLL4(9), MLL5(7), OGT(3), PAXIP1(2), PRDM2(5), PRDM7(1), PRDM9(22), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SATB1(5), SETD1A(6), SETD2(8), SETD7(2), SETD8(1), SETDB1(6), SETMAR(1), SMYD3(1), STK38(2), SUV39H1(2), SUV420H1(4), SUV420H2(2), SUZ12(1), WHSC1(7), WHSC1L1(1) 47117902 209 129 207 55 20 43 71 30 44 1 0.227 1.000 1.000 307 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CD2BP2(3), CDC40(2), CLK2(5), CLK3(3), COL2A1(4), CPSF1(3), CPSF2(3), CSTF1(1), CSTF2(2), CSTF2T(1), CSTF3(1), DDX1(3), DDX20(3), DHX15(1), DHX16(4), DHX38(1), DHX8(3), DHX9(5), DICER1(7), DNAJC8(2), FUS(2), GIPC1(1), LOC440563(2), LSM2(1), METTL3(2), NCBP1(4), NCBP2(3), NONO(2), NUDT21(2), NXF1(3), PABPN1(2), PAPOLA(2), PHF5A(1), POLR2A(9), PRPF4(1), PRPF4B(4), PRPF8(6), PTBP2(1), RBM17(1), RBM5(6), RNGTT(1), RNMT(2), RNPS1(1), SF3A1(1), SF3A2(1), SF3B1(3), SF3B2(1), SF3B5(1), SF4(1), SFRS12(2), SFRS14(2), SFRS16(5), SFRS2(2), SFRS4(3), SFRS5(3), SFRS6(4), SFRS7(3), SFRS8(4), SFRS9(1), SNRPA(2), SNRPA1(1), SNRPB(1), SNRPB2(1), SNRPD2(2), SNRPN(5), SNURF(1), SPOP(4), SRPK2(5), SRRM1(3), SUPT5H(3), U2AF1(3), XRN2(5) 48212981 189 125 188 64 24 49 58 33 25 0 0.682 1.000 1.000 308 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 90 ACTB(2), BAD(1), BCL2(1), CABIN1(7), CALM1(1), CALM3(1), CAMK2B(2), CD69(1), CEBPB(1), CNR1(3), CREBBP(15), CSNK2A1(6), CSNK2B(2), CTLA4(1), EGR2(2), FCER1A(2), FCGR3A(4), FOS(1), GATA3(6), GRLF1(12), GSK3B(1), ICOS(1), IFNG(1), IL13(1), IL1B(1), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(1), KPNA5(1), MAPK14(1), MAPK8(4), MAPK9(4), MEF2A(1), MEF2B(2), MYF5(4), NCK2(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB2(1), NFKBIB(1), NPPB(1), NUP214(8), OPRD1(2), PAK1(1), PIN1(1), PTPRC(13), RELA(1), RPL13A(1), SFN(5), SLA(1), SP1(1), SP3(1), TGFB1(1), TRAF2(1), TRPV6(4), VAV1(2), VAV2(1), VAV3(1), XPO5(1) 39096074 177 122 177 64 24 37 53 37 26 0 0.594 1.000 1.000 309 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 79 ATM(9), BUB1(2), BUB1B(4), CCNA1(4), CCNA2(3), CCNB1(3), CCNB3(5), CCNE1(3), CCNE2(3), CDAN1(7), CDC14A(2), CDC20(2), CDC25B(3), CDC6(2), CDC7(1), CDH1(4), CDK4(4), CHEK2(4), DTX4(3), E2F2(3), E2F4(1), E2F5(4), E2F6(1), ESPL1(9), GSK3B(1), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), HDAC8(1), MAD1L1(4), MAD2L2(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MPEG1(1), MPL(2), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), PLK1(2), PRKDC(15), PTPRA(4), RB1(10), RBL1(8), SKP2(2), SMAD4(8), TBC1D8(2), TFDP1(2), TGFB1(1), WEE1(1) 47156157 187 122 187 63 25 42 52 32 36 0 0.555 1.000 1.000 310 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 82 ATF2(1), BRAF(4), CHUK(3), CREB1(1), ELK1(1), FOS(1), IKBKB(5), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K5(2), MAP2K6(1), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K14(2), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K6(3), MAP3K7(4), MAP3K8(1), MAP3K9(2), MAP4K1(2), MAP4K2(1), MAP4K3(5), MAP4K4(2), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK4(6), MAPK6(3), MAPK7(1), MAPK8(4), MAPK9(4), MAPKAPK3(2), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MKNK2(1), MYC(3), NFKB1(2), PAK1(1), PAK2(5), RAF1(2), RELA(1), RIPK1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA4(3), RPS6KA5(4), RPS6KB1(3), RPS6KB2(1), SHC1(1), SP1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1) 43022297 183 121 179 55 29 36 66 25 27 0 0.295 1.000 1.000 311 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 70 ACACB(12), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ADIPOR1(2), ADIPOR2(3), AKT1(2), AKT2(3), AKT3(4), CAMKK1(1), CAMKK2(5), CHUK(3), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), G6PC(2), G6PC2(3), IKBKB(5), IRS1(1), IRS2(2), IRS4(9), JAK1(6), JAK2(2), JAK3(3), LEP(1), LEPR(11), MAPK10(3), MAPK8(4), MAPK9(4), NFKB1(2), NFKB2(1), NFKBIB(1), NPY(2), PCK2(2), POMC(1), PPARGC1A(3), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2), PRKAG3(2), PRKCQ(5), PTPN11(1), RELA(1), RXRA(4), RXRB(2), RXRG(6), SLC2A1(3), SLC2A4(1), STAT3(3), STK11(3), TRAF2(1), TYK2(2) 37823107 176 118 175 57 25 36 59 32 24 0 0.398 1.000 1.000 312 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 27 BRAF(4), CPEB1(4), EGFR(14), ERBB2(8), ERBB4(15), ETS1(2), ETS2(5), ETV6(4), ETV7(1), FMN2(21), KRAS(1), MAP2K1(4), MAPK1(4), NOTCH2(13), NOTCH3(14), NOTCH4(5), PIWIL1(8), PIWIL2(4), PIWIL3(3), PIWIL4(2), RAF1(2), SOS1(7), SOS2(9), SPIRE1(4) 21971044 158 116 152 41 26 31 55 24 22 0 0.247 1.000 1.000 313 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 65 A2M(3), BDKRB1(1), C1QC(1), C1R(3), C1S(3), C3(7), C3AR1(2), C4BPA(1), C4BPB(2), C5(5), C5AR1(1), C7(5), C8A(6), C8B(4), C8G(1), C9(5), CD46(1), CFB(1), CFH(9), CFI(5), CPB2(3), CR1(8), CR2(5), F10(3), F11(2), F12(1), F2(2), F3(1), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), KNG1(3), MASP1(4), MASP2(4), MBL2(2), PLAT(2), PLAU(1), PLG(8), PROS1(5), SERPINA1(3), SERPINA5(4), SERPINC1(3), SERPIND1(3), SERPINE1(4), SERPING1(3), THBD(2), VWF(6) 39788954 188 115 188 81 14 48 64 30 31 1 0.949 1.000 1.000 314 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 61 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2L1(2), CDC42(1), CDKN1B(2), CREB1(1), CREB5(5), ERBB4(15), F2RL2(1), GAB1(2), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(9), MET(1), MYC(3), NOLC1(3), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PARD3(10), PARD6A(1), PDK1(1), PIK3CD(2), PPP1R13B(1), PREX1(6), PTEN(6), PTK2(5), PTPN1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SLC2A4(1), SOS1(7), SOS2(9), TSC1(2), TSC2(3), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 33990785 167 115 166 51 17 40 55 28 27 0 0.218 1.000 1.000 315 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 71 AKT1(2), AKT2(3), AKT3(4), BTK(5), FCER1A(2), FYN(3), GAB2(2), IL13(1), IL3(1), IL4(1), IL5(1), INPP5D(7), KRAS(1), LAT(3), LCP2(1), LYN(3), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MS4A2(2), NRAS(1), PDK1(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCD(4), PRKCE(2), RAC2(1), RAC3(2), RAF1(2), SOS1(7), SOS2(9), SYK(2), VAV1(2), VAV2(1), VAV3(1) 31462599 164 114 161 54 26 33 54 31 19 1 0.481 1.000 1.000 316 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 46 FN3K(2), IMPA1(1), IMPA2(2), INPP1(2), INPP4A(4), INPP4B(7), INPP5B(3), INPPL1(4), IPMK(2), ISYNA1(2), ITPK1(2), ITPKA(1), ITPKB(4), MIOX(2), OCRL(4), PI4KA(5), PIK3C3(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIP4K2B(3), PIP4K2C(2), PIP5K1A(4), PIP5K1B(4), PIP5K1C(2), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCD4(2), PLCE1(12), PLCG1(5), PLCG2(4), PLCZ1(3), PTEN(6), PTPMT1(2), SYNJ1(6), SYNJ2(5) 32831248 156 112 155 56 28 26 52 29 20 1 0.460 1.000 1.000 317 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 77 AIFM1(1), AKT1(2), AKT2(3), AKT3(4), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CAPN2(4), CASP10(2), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), CHUK(3), CSF2RB(5), FADD(1), FAS(1), FASLG(1), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IL3(1), IL3RA(3), IRAK1(1), IRAK2(2), IRAK3(4), IRAK4(3), MAP3K14(2), NFKB1(2), NFKB2(1), NTRK1(3), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKACA(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), RIPK1(2), TNFRSF10A(1), TNFRSF10B(1), TRAF2(1) 36170479 146 107 146 46 28 39 31 30 17 1 0.240 1.000 1.000 318 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 66 AKT1(2), AKT2(3), AKT3(4), BAD(1), CDC42(1), KDR(5), KRAS(1), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPKAPK3(2), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NOS3(4), NRAS(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCG1(5), PLCG2(4), PRKCA(2), PRKCG(7), PTGS2(2), PTK2(5), PXN(1), RAC2(1), RAC3(2), RAF1(2), SHC2(3), SPHK2(1), SRC(1) 31459937 146 107 143 57 35 28 42 25 15 1 0.614 1.000 1.000 319 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(5), AMY2A(2), AMY2B(6), ENPP1(5), ENPP3(5), G6PC(2), GAA(3), GANAB(1), GBA3(5), GCK(2), GPI(2), GUSB(1), GYS1(5), GYS2(5), HK1(3), HK2(5), HK3(4), MGAM(18), PGM1(3), PGM3(1), PYGB(3), PYGL(4), PYGM(3), SI(39), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UXS1(2) 25874629 158 107 157 54 21 27 55 35 20 0 0.740 1.000 1.000 320 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 59 AKT1(2), AKT2(3), AKT3(4), BCL10(1), BLNK(3), BTK(5), CARD11(4), CD19(2), CD22(1), CD72(1), CHUK(3), CR2(5), FCGR2B(1), FOS(1), GSK3B(1), IKBKB(5), INPP5D(7), KRAS(1), LILRB3(5), LYN(3), MALT1(3), NFAT5(5), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), NFKB2(1), NFKBIB(1), NRAS(1), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PLCG2(4), PTPN6(1), RAC2(1), RAC3(2), RASGRP3(3), SYK(2), VAV1(2), VAV2(1), VAV3(1) 32611025 142 106 142 57 29 33 37 24 18 1 0.690 1.000 1.000 321 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 82 CD14(1), CD19(2), CD1A(4), CD1B(1), CD1C(2), CD1D(4), CD2(1), CD22(1), CD33(2), CD34(4), CD38(2), CD3D(1), CD44(1), CD7(2), CD8A(2), CD8B(1), CD9(1), CR1(8), CR2(5), CSF1(1), CSF2RA(1), CSF3R(2), EPO(2), FCER2(2), FCGR1A(1), FLT3(4), FLT3LG(1), GP5(3), GP9(1), GYPA(3), HLA-DRA(1), IL1A(1), IL1B(1), IL1R1(2), IL1R2(1), IL2RA(2), IL3(1), IL3RA(3), IL4(1), IL4R(2), IL5(1), IL5RA(1), IL6R(4), IL7R(3), IL9R(4), ITGA1(3), ITGA2(4), ITGA2B(3), ITGA3(3), ITGA4(6), ITGA5(1), ITGA6(3), ITGAM(3), ITGB3(5), KIT(5), MME(11), MS4A1(2), TFRC(3), TPO(10) 36829029 156 104 155 62 25 32 56 27 16 0 0.854 1.000 1.000 322 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 64 AGTR2(2), ATP8A1(9), AVPR1A(5), AVPR1B(4), AVPR2(1), BDKRB1(1), BRS3(2), C3AR1(2), CCKAR(4), CCKBR(3), CCR1(1), CCR10(1), CCR2(2), CCR3(3), CCR4(1), CCR6(1), CCR7(1), CX3CR1(1), CXCR3(1), CXCR4(1), EDNRB(3), FPR1(3), FSHR(5), GALR1(2), GALR2(3), GALT(1), GHSR(3), GNB2L1(1), GPR77(2), GRPR(1), LHCGR(2), MC2R(6), MC3R(3), MC4R(3), MC5R(5), NMBR(2), NPY1R(5), NPY2R(3), NTSR1(2), NTSR2(5), OPRD1(2), OPRK1(2), OPRL1(1), OXTR(2), PPYR1(1), SSTR1(5), SSTR2(1), SSTR3(5), SSTR4(6), TACR1(2), TACR2(2), TACR3(5), TRHR(4), TSHR(2) 23099743 146 104 146 60 28 34 51 16 17 0 0.351 1.000 1.000 323 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 53 ADORA3(2), ALG6(2), CCKBR(3), CCR2(2), CCR3(3), CELSR1(9), CELSR2(18), CELSR3(12), CHRM2(4), CHRM3(5), CXCR3(1), DRD4(1), EMR2(2), EMR3(2), FSHR(5), GHRHR(2), GPR116(4), GPR132(2), GPR133(7), GPR143(1), GPR17(1), GPR18(1), GPR55(1), GPR77(2), GPR84(2), GRM1(16), GRPR(1), HRH4(3), LGR6(5), LPHN2(8), LPHN3(14), LTB4R2(1), NTSR1(2), OR2M4(4), OR8G2(3), P2RY13(2), PTGFR(2), SMO(1), SSTR2(1), TSHR(2), VN1R1(1) 30291802 160 103 160 62 25 45 51 27 12 0 0.337 1.000 1.000 324 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 85 AICDA(2), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ENTPD3(1), ENTPD4(4), ENTPD5(2), ENTPD6(1), ENTPD8(1), ITPA(3), NME7(2), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT2(1), PNPT1(4), POLA1(2), POLA2(2), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1), RFC5(2), RRM1(1), RRM2(1), RRM2B(1), TXNRD1(3), TXNRD2(1), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UPB1(1), UPP1(1), UPP2(4), UPRT(2) 36498221 139 101 139 58 25 25 49 20 20 0 0.933 1.000 1.000 325 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADL(2), ACADM(3), ACOX2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADIPOQ(1), ANGPTL4(3), APOA2(1), APOA5(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP27A1(2), CYP4A11(8), CYP4A22(6), CYP7A1(2), CYP8B1(3), DBI(2), EHHADH(2), FABP1(1), FABP2(1), FABP3(1), FABP4(2), FABP5(1), FABP6(2), FABP7(1), FADS2(2), GK(1), GK2(7), HMGCS2(2), ILK(4), LPL(2), ME1(2), MMP1(4), OLR1(1), PCK2(2), PDPK1(2), RXRA(4), RXRB(2), RXRG(6), SCD(1), SLC27A1(1), SLC27A2(2), SLC27A4(2), SLC27A5(2), SLC27A6(5), SORBS1(2), UBC(4) 29828246 136 99 136 39 20 27 49 16 24 0 0.166 1.000 1.000 326 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(4), ASAH1(1), BRAF(4), DAG1(1), DRD2(2), EGFR(14), EPHB2(2), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PI3(1), PIK3CB(5), PITX2(1), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), RAF1(2), RGS20(2), SHC1(1), SOS1(7), SOS2(9), SRC(1), STAT3(3) 26560548 136 98 132 43 21 28 42 32 13 0 0.272 1.000 1.000 327 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 43 ACTR2(1), AKT1(2), AKT2(3), AKT3(4), ANGPTL2(2), ARHGAP1(2), ARHGAP4(5), ARHGEF11(3), BTK(5), CDC42(1), CFL1(2), GDI1(2), GDI2(2), INPPL1(4), ITPR1(8), ITPR2(11), ITPR3(5), LIMK1(5), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PDK1(1), PIK3CD(2), PIK3CG(8), PIK3R1(6), PITX2(1), PPP1R13B(1), PTEN(6), RACGAP1(3), RHO(3), ROCK1(11), ROCK2(5), WASF1(3), WASL(1) 30883269 142 97 141 54 18 39 39 26 19 1 0.616 1.000 1.000 328 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 62 APAF1(9), ATM(9), ATR(18), BAI1(4), BAX(1), BID(2), CASP3(1), CCNB1(3), CCNB3(5), CCND1(2), CCNE1(3), CCNE2(3), CCNG1(1), CCNG2(2), CDK4(4), CDK6(1), CHEK2(4), DDB2(2), EI24(1), FAS(1), GADD45G(1), GTSE1(4), IGFBP3(1), LRDD(3), MDM2(2), MDM4(1), PERP(1), PMAIP1(2), PPM1D(2), PTEN(6), RCHY1(1), RFWD2(1), RRM2(1), RRM2B(1), SERPINE1(4), SESN3(1), SFN(5), SIAH1(1), STEAP3(2), THBS1(7), TNFRSF10B(1), TSC2(3) 28630402 127 96 127 33 13 29 29 35 21 0 0.132 1.000 1.000 329 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 AADAT(1), AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), AFMID(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CARM1(3), CAT(2), CYP1A2(4), CYP1B1(1), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HEMK1(1), HSD17B4(3), KMO(1), KYNU(6), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), NFX1(2), OGDH(6), OGDHL(9), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), TDO2(2), TPH1(2), TPH2(4), WARS2(5) 27547564 124 95 124 37 20 26 36 18 24 0 0.288 1.000 1.000 330 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 64 ADAM10(3), ADAM17(4), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), CASP3(1), CDC42(1), CHUK(3), CSK(1), CXCL1(1), EGFR(14), F11R(1), GIT1(1), IGSF5(3), IKBKB(5), LYN(3), MAP2K4(1), MAP3K14(2), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK9(4), MET(1), NFKB1(2), NFKB2(1), NOD1(4), PAK1(1), PLCG1(5), PLCG2(4), PTPN11(1), PTPRZ1(6), RELA(1), SRC(1), TCIRG1(7), TJP1(9) 31835220 131 95 131 45 12 30 46 28 15 0 0.631 1.000 1.000 331 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 62 ATM(9), CCNA1(4), CCNB1(3), CCND1(2), CCNE1(3), CCNE2(3), CCNG2(2), CDK4(4), CDKN1B(2), CREB3L1(2), CREB3L3(3), CREB3L4(1), E2F2(3), E2F4(1), E2F5(4), E2F6(1), GBA2(3), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), MDM2(2), MNAT1(2), MYC(3), MYT1(7), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(2), POLE(8), POLE2(1), RB1(10), RBL1(8), RPA1(4), TFDP1(2), TFDP2(1), TNXB(10), WEE1(1) 34511048 138 94 137 50 17 29 45 24 23 0 0.764 1.000 1.000 332 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 47 AKT1(2), AKT2(3), AKT3(4), BRD4(5), CAP1(2), CBL(2), CDC42(1), F2RL2(1), FLOT1(1), FLOT2(3), GSK3B(1), IGFBP1(2), INPPL1(4), IRS1(1), IRS2(2), IRS4(9), LNPEP(2), MAPK1(4), PARD3(10), PARD6A(1), PDK1(1), PIK3CD(2), PIK3R1(6), PPYR1(1), PTEN(6), PTPN1(2), RAF1(2), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SERPINB6(3), SFN(5), SHC1(1), SLC2A4(1), SORBS1(2), SOS1(7), SOS2(9), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 25887359 130 94 126 39 23 28 42 22 15 0 0.208 1.000 1.000 333 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 45 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), BCR(1), BLNK(3), BTK(5), CD19(2), CD22(1), CR2(5), CSK(1), DAG1(1), FLOT1(1), FLOT2(3), GSK3B(1), INPP5D(7), ITPR1(8), ITPR2(11), ITPR3(5), LYN(3), MAP4K1(2), MAPK1(4), NFATC1(7), NFATC2(6), NR0B2(1), PDK1(1), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), PTPRC(13), RAF1(2), SHC1(1), SOS1(7), SOS2(9), SYK(2), VAV1(2) 32669101 139 92 136 57 21 34 34 30 20 0 0.704 1.000 1.000 334 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 56 BMP2(3), BMP4(2), BMP5(2), BMP6(2), BMP7(3), BMP8B(3), BTRC(1), CSNK1A1(1), CSNK1E(3), CSNK1G1(1), GLI1(5), GLI2(8), GLI3(5), GSK3B(1), HHIP(2), LRP2(24), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), PTCH1(11), PTCH2(5), RAB23(2), SMO(1), STK36(4), SUFU(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT3A(1), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1), WNT8A(1), WNT8B(2), WNT9A(3), WNT9B(1), ZIC2(3) 27678560 128 91 128 47 28 22 50 16 12 0 0.577 1.000 1.000 335 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 41 ADAM17(4), APH1A(2), CREBBP(15), CTBP1(1), CTBP2(2), DLL1(4), DLL3(1), DLL4(2), DTX1(2), DTX2(1), DTX3(2), DTX3L(1), DTX4(3), DVL1(2), DVL2(1), DVL3(4), JAG1(6), JAG2(4), LFNG(2), MAML1(1), MAML2(2), MAML3(1), NCOR2(11), NCSTN(1), NOTCH2(13), NOTCH3(14), NOTCH4(5), NUMB(2), PTCRA(2), RBPJ(2), RBPJL(2), RFNG(2), SNW1(2) 27500704 119 90 119 46 24 25 34 14 22 0 0.711 1.000 1.000 336 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 57 APC(17), AXIN1(5), CCND1(2), CSNK1E(3), CTNNB1(2), DVL1(2), DVL2(1), DVL3(4), FZD1(3), FZD10(1), FZD2(2), FZD3(2), FZD5(1), FZD6(2), FZD8(1), GSK3B(1), LDLR(3), MAPK10(3), MAPK9(4), MYC(3), PLAU(1), PPP2R5C(2), PPP2R5E(1), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCI(2), PRKCQ(5), PRKCZ(3), PRKD1(10), RHOA(4), SFRP4(8), TCF7(1), WNT1(1), WNT10A(2), WNT10B(1), WNT11(1), WNT16(1), WNT2(3), WNT3(4), WNT4(1), WNT5A(2), WNT5B(1), WNT7A(1), WNT7B(1) 27149849 136 90 133 52 18 26 56 23 12 1 0.750 1.000 1.000 337 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 43 CBL(2), CD28(2), CD3D(1), CSK(1), CTLA4(1), DAG1(1), EPHB2(2), GRAP2(1), ITK(1), ITPKA(1), ITPKB(4), LAT(3), LCK(5), LCP2(1), MAPK1(4), NCK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), PLCG1(5), PTPRC(13), RAF1(2), RASGRP1(5), RASGRP2(3), RASGRP3(3), RASGRP4(3), SOS1(7), SOS2(9), VAV1(2), ZAP70(2) 24704887 116 89 113 37 18 24 35 17 22 0 0.381 1.000 1.000 338 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 AANAT(1), ABP1(3), ACAT2(1), ACMSD(4), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), AOX1(5), ASMT(2), CAT(2), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), DDC(7), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), KMO(1), KYNU(6), MAOA(1), MAOB(1), TDO2(2), TPH1(2), WARS2(5) 25058904 115 89 115 34 18 23 37 17 20 0 0.205 1.000 1.000 339 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 56 ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), CARM1(3), DBH(4), DCT(1), DDC(7), ESCO1(3), ESCO2(3), FAH(1), GOT1(1), GOT2(2), HEMK1(1), HGD(2), HPD(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), MYST3(4), MYST4(6), PNMT(1), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SH3GLB1(2), TAT(1), TH(2), TPO(10), TYR(4), TYRP1(1) 27085348 117 88 116 39 20 30 37 13 17 0 0.442 1.000 1.000 340 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 57 ALG2(2), BAX(1), BTK(5), CAD(2), CASP10(2), CASP3(1), CASP8AP2(3), CD7(2), CSNK1A1(1), DEDD(1), DEDD2(2), DIABLO(1), EGFR(14), EPHB2(2), FADD(1), FAF1(1), IL1A(1), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MET(1), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR0B2(1), PTPN13(9), RALBP1(2), RIPK1(2), ROCK1(11), SMPD1(1), TNFRSF6B(2), TPX2(4), TRAF2(1) 32291864 120 88 117 39 19 26 41 17 17 0 0.458 1.000 1.000 341 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AGK(1), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CEL(1), DAK(3), DGAT2(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), GK(1), GK2(7), GLA(3), GLB1(4), GPAM(3), LCT(8), LIPA(1), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1) 26704718 119 87 119 32 17 28 29 26 19 0 0.0611 1.000 1.000 342 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 43 AKT1(2), AKT2(3), AKT3(4), BRAF(4), DDIT4(1), EIF4B(2), EIF4EBP1(1), HIF1A(2), MAPK1(4), PDPK1(2), PIK3CB(5), PIK3CD(2), PIK3CG(8), PIK3R1(6), PIK3R2(3), PIK3R3(3), PIK3R5(6), PRKAA1(3), PRKAA2(2), RICTOR(7), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), STK11(3), TSC1(2), TSC2(3), ULK1(5), ULK2(2), VEGFC(3) 23184866 107 86 104 32 23 21 28 18 16 1 0.313 1.000 1.000 343 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 49 ACTA1(2), AGT(2), AKT1(2), CALM1(1), CALM3(1), CALR(2), CAMK1(1), CAMK1G(1), CREBBP(15), CSNK1A1(1), F2(2), FGF2(1), GSK3B(1), HAND2(2), LIF(2), MAP2K1(4), MAPK1(4), MAPK14(1), MAPK8(4), MEF2C(7), MYH2(16), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NKX2-5(1), NPPA(1), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAF1(2), RPS6KB1(3), SYT1(5) 21932228 119 86 116 37 24 27 36 17 15 0 0.186 1.000 1.000 344 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), ASCC3(5), DDX18(1), DDX19A(3), DDX23(1), DDX4(3), DDX41(2), DDX50(1), DDX51(2), DDX52(4), DDX54(4), DDX55(3), DDX56(3), DHFR(3), DHX58(2), ENTPD7(3), EP400(7), ERCC2(2), ERCC3(4), FPGS(2), IFIH1(5), MOV10L1(2), NUDT5(1), NUDT8(1), RAD54B(2), RAD54L(4), RUVBL2(2), SETX(9), SKIV2L2(3), SMARCA2(8), SMARCA5(1) 28632935 104 85 104 31 11 21 39 20 13 0 0.413 1.000 1.000 345 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(6), ADCY4(6), ADCY6(4), ADCY8(13), CACNA1A(7), CACNA1B(4), GNAS(6), GNAT3(3), GNB1(2), GNB3(3), GRM4(2), ITPR3(5), KCNB1(3), PDE1A(3), PLCB2(4), PRKACA(4), PRKACB(2), PRKACG(1), PRKX(1), SCNN1A(3), SCNN1B(2), SCNN1G(4), TAS1R1(1), TAS1R2(2), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R14(1), TAS2R16(3), TAS2R3(1), TAS2R38(2), TAS2R39(1), TAS2R40(4), TAS2R41(1), TAS2R42(1), TAS2R43(1), TAS2R46(2), TAS2R60(1), TAS2R7(2), TAS2R8(3), TRPM5(3) 25874670 121 85 121 60 34 18 28 26 15 0 0.943 1.000 1.000 346 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 ACTA1(2), AKT1(2), CALM1(1), CALM3(1), FLT1(10), FLT4(6), KDR(5), NOS3(4), PDE2A(1), PDE3A(12), PDE3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKG1(3), PRKG2(1), RYR2(44), SLC7A1(2), SYT1(5) 18432057 108 85 108 41 19 26 36 18 8 1 0.670 1.000 1.000 347 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 48 APOA2(1), CPT1B(3), CREBBP(15), EHHADH(2), FABP1(1), HSD17B4(3), LPL(2), MAPK1(4), ME1(2), MYC(3), NCOA1(4), NCOR1(12), NCOR2(11), NR0B2(1), NR2F1(2), NRIP1(4), PIK3R1(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), PTGS2(2), RB1(10), RELA(1), RXRA(4), SP1(1), STAT5A(1), STAT5B(4) 25603695 109 85 104 31 11 27 31 16 24 0 0.222 1.000 1.000 348 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 33 AKT1(2), APC(17), AR(3), ASAH1(1), BRAF(4), CCL15(1), DAG1(1), EGFR(14), GNA15(2), GNAI1(1), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), MAPK10(3), MAPK14(1), PHKA2(9), PIK3CD(2), PIK3R1(6), PITX2(1), PTX3(2), RAF1(2), SRC(1) 23165352 114 85 110 38 20 22 35 20 17 0 0.415 1.000 1.000 349 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(5), ACSS2(2), ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), G6PC2(3), GAPDHS(1), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKL(4), PFKM(2), PFKP(3), PGAM1(1), PGAM4(1), PGK2(3), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2) 26472566 106 84 106 39 20 21 28 17 20 0 0.642 1.000 1.000 350 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 50 ACTG1(2), APAF1(9), BAG4(4), BCL2(1), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), CHUK(3), CRADD(1), FADD(1), GSN(5), LMNB1(1), LMNB2(4), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK8(4), MDM2(2), NFKB1(2), NUMA1(5), PAK2(5), PRKCD(4), PRKDC(15), PTK2(5), RB1(10), RELA(1), RIPK1(2), SPTAN1(11), TRAF2(1) 30103025 118 83 118 39 16 23 32 17 30 0 0.566 1.000 1.000 351 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 AK3L1(1), CAD(2), CANT1(1), CDA(1), CTPS(1), DCK(2), DHODH(4), DPYD(8), DPYS(5), ENTPD1(2), ITPA(3), NUDT2(1), POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16), POLR1B(3), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLRMT(4), RRM1(1), RRM2(1), TXNRD1(3), TYMS(1), UCK1(2), UCK2(4), UMPS(1), UNG(1), UPB1(1), UPP1(1) 26116929 107 82 107 37 16 20 40 14 17 0 0.493 1.000 1.000 352 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 41 AKT1(2), ASAH1(1), ATF1(2), BRAF(4), CREB1(1), CREB5(5), CREBBP(15), CRKL(1), DAG1(1), EGR1(3), EGR2(2), ELK1(1), MAP1B(12), MAP2K4(1), MAPK1(4), MAPK10(3), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), NTRK1(3), OPN1LW(2), PIK3C2G(7), PIK3CD(2), PIK3R1(6), PTPN11(1), RPS6KA3(3), SHC1(1), SRC(1), TH(2) 22417691 104 82 101 29 15 23 34 16 16 0 0.229 1.000 1.000 353 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 AKR1C4(2), AKR1D1(2), ARSD(1), ARSE(1), CARM1(3), CYP11B1(4), CYP11B2(3), CYP19A1(1), HEMK1(1), HSD11B2(1), HSD17B12(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), LCMT1(1), LCMT2(6), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4) 22848351 109 81 109 36 18 20 43 18 10 0 0.527 1.000 1.000 354 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 63 ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CHPT1(1), CRLS1(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKI(8), DGKQ(5), DGKZ(4), ESCO1(3), ESCO2(3), ETNK2(1), GNPAT(3), GPAM(3), GPD1(1), GPD2(2), LCAT(2), MYST3(4), MYST4(6), PCYT1A(1), PLA2G12A(1), PLA2G12B(1), PLA2G2D(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLD1(8), PLD2(1), PPAP2B(1), PTDSS1(6), PTDSS2(1), SH3GLB1(2) 29766289 114 81 114 36 12 22 35 21 24 0 0.430 1.000 1.000 355 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(21), B3GALT4(3), CDR1(3), DGKI(8), IL6ST(2), MRPL19(1), PIGK(5), RPL10(2), RPL12(1), RPL13A(1), RPL18(2), RPL22(1), RPL23(1), RPL26(1), RPL28(1), RPL31(1), RPL36(2), RPL37(1), RPL3L(1), RPL4(1), RPL6(2), RPLP0(2), RPLP2(1), RPS10(1), RPS13(2), RPS15(1), RPS19(1), RPS20(1), RPS21(1), RPS23(1), RPS27A(1), RPS28(1), RPS3(1), RPS5(1), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KA6(4), RPS6KB1(3), RPS6KB2(1), SLC36A2(1), TBC1D10C(3), TSPAN9(1), UBA52(2), UBB(1), UBC(4) 23815448 107 80 106 43 12 21 45 13 16 0 0.926 1.000 1.000 356 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 69 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), ALDH3B1(1), ALDH3B2(2), CYP1A2(4), CYP1B1(1), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2E1(5), CYP2F1(2), CYP2S1(1), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), EPHX1(1), GSTA1(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), MGST1(1), MGST3(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4) 26186719 121 79 121 41 13 26 47 24 11 0 0.481 1.000 1.000 357 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(5), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2) 23144073 103 79 100 40 21 22 37 10 12 1 0.624 1.000 1.000 358 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 50 ACTB(2), ACTG1(2), ARHGEF2(1), CD14(1), CDC42(1), CDH1(4), CTNNB1(2), CTTN(4), FYN(3), HCLS1(2), KRT18(1), LY96(1), NCK1(4), NCK2(3), NCL(3), PRKCA(2), RHOA(4), ROCK1(11), ROCK2(5), TLR4(7), TLR5(1), TUBA1B(3), TUBA3C(6), TUBA3D(2), TUBA3E(3), TUBA4A(1), TUBA8(2), TUBAL3(3), TUBB1(1), TUBB2C(1), TUBB3(2), TUBB4(3), TUBB4Q(4), TUBB6(3), TUBB8(1), WASL(1), YWHAQ(1), YWHAZ(2) 23144073 103 79 100 40 21 22 37 10 12 1 0.624 1.000 1.000 359 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 22 IMPA1(1), INPP1(2), INPP4A(4), INPP4B(7), INPPL1(4), ITPKA(1), ITPKB(4), MIOX(2), OCRL(4), PIK3C2A(4), PIK3C2B(7), PIK3C2G(7), PIK3CB(5), PIK3CG(8), PLCB1(12), PLCB2(4), PLCB3(5), PLCB4(9), PLCD1(2), PLCG1(5), PLCG2(4) 19401948 101 79 100 26 21 16 31 20 12 1 0.108 1.000 1.000 360 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 35 ACTG1(2), ACTG2(3), ACTR2(1), AKT1(2), ANGPTL2(2), CDC42(1), CFL1(2), FLNA(8), FLNC(8), FSCN1(1), FSCN2(1), FSCN3(5), GDI1(2), GDI2(2), LIMK1(5), MYH2(16), MYLK(4), MYLK2(2), PAK1(1), PAK2(5), PAK3(2), PAK4(1), PAK6(2), PAK7(7), RHO(3), ROCK1(11), ROCK2(5), VASP(1), WASF1(3), WASL(1) 21807472 109 78 109 37 15 35 28 19 12 0 0.266 1.000 1.000 361 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 46 AADAT(1), AASDHPPT(3), ACAT2(1), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), HSD17B4(3), OGDH(6), OGDHL(9), PIPOX(1), PLOD1(3), PLOD2(7), PLOD3(4), RDH11(1), RDH12(3), SETD1A(6), SETD7(2), SETDB1(6), SHMT1(1), SHMT2(2), SPCS3(1), SUV39H1(2), TMLHE(2) 23926013 102 77 102 42 18 21 32 19 12 0 0.824 1.000 1.000 362 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 38 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCR(1), BLNK(3), BTK(5), CD19(2), CSK(1), DAG1(1), EPHB2(2), ITPKA(1), ITPKB(4), LYN(3), MAP2K1(4), MAP2K2(3), MAPK1(4), NFAT5(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PI3(1), PIK3CD(2), PIK3R1(6), PLCG2(4), PPP1R13B(1), RAF1(2), SERPINA4(6), SHC1(1), SOS1(7), SOS2(9), SYK(2), VAV1(2) 23092362 97 77 94 38 18 22 27 15 15 0 0.684 1.000 1.000 363 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 24 BRCA1(9), CARM1(3), CCND1(2), CREBBP(15), ERCC3(4), ESR1(3), GRIP1(5), GTF2A1(2), GTF2E1(5), GTF2F1(3), HDAC3(1), HDAC4(3), HDAC5(1), HDAC6(5), MEF2C(7), NCOR2(11), NR0B1(3), NRIP1(4), PELP1(1), POLR2A(9), TBP(1) 18680679 97 76 97 36 7 23 36 16 15 0 0.740 1.000 1.000 364 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), CEL(1), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GK(1), GLA(3), GLB1(4), LCT(8), LIPC(3), LIPG(1), LPL(2), PNLIP(2), PNLIPRP1(5), PNLIPRP2(6), PPAP2B(1) 21937918 97 76 97 27 15 22 20 21 19 0 0.0891 1.000 1.000 365 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 41 BCL2(1), CHUK(3), EGF(6), EGFR(14), ETS1(2), ETS2(5), FOS(1), HOXA7(2), IKBKB(5), MAP2K1(4), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K5(5), MAPK1(4), MAPK13(3), MAPK14(1), MAPK8(4), NFKB1(2), PRKCA(2), PRKCD(4), PRKCE(2), PRKCG(7), PRKCH(3), PRKCQ(5), RAF1(2), RELA(1), RIPK1(2), SP1(1), TRAF2(1) 22179930 102 76 99 38 20 18 31 16 17 0 0.723 1.000 1.000 366 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 31 AKT1(2), AKT2(3), AKT3(4), BCR(1), BTK(5), CD19(2), FLOT1(1), FLOT2(3), GAB1(2), ITPR1(8), ITPR2(11), ITPR3(5), LYN(3), NR0B2(1), PDK1(1), PITX2(1), PLCG2(4), PPP1R13B(1), PREX1(6), PTEN(6), PTPRC(13), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SYK(2), TEC(2), VAV1(2) 23808098 103 76 103 40 11 28 23 22 19 0 0.596 1.000 1.000 367 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(11), ACACB(12), ACAT2(1), ACOT12(2), ACSS1(5), ACSS2(2), ACYP1(1), AKR1B1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(2), ME2(1), ME3(6), PC(7), PCK2(2), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3) 21292840 90 75 90 36 24 17 26 15 8 0 0.801 1.000 1.000 368 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(6), ATP4A(3), ATP4B(2), ATP5F1(1), ATP5G2(1), ATP5G3(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), COX10(1), COX15(2), COX17(2), COX5B(1), COX7B2(1), COX8A(1), LHPP(1), NDUFA12(1), NDUFA13(2), NDUFA2(1), NDUFA3(1), NDUFA5(3), NDUFA7(1), NDUFA9(1), NDUFB10(1), NDUFB3(2), NDUFB4(1), NDUFB6(1), NDUFB9(1), NDUFS1(1), NDUFS2(1), NDUFS3(1), NDUFS4(1), NDUFS7(1), NDUFS8(1), NDUFV1(1), PPA1(1), SDHA(4), SDHC(1), TCIRG1(7), UQCRC1(1), UQCRFS1(3) 25453896 89 73 89 30 10 23 26 17 13 0 0.437 1.000 1.000 369 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 64 APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BCL2L11(1), BID(2), BIRC2(1), BIRC3(1), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CHUK(3), FADD(1), FAS(1), FASLG(1), GZMB(1), HELLS(4), IKBKB(5), IRF1(5), IRF2(2), IRF3(1), IRF4(2), IRF5(1), IRF6(4), IRF7(2), LTA(1), MAP2K4(1), MAP3K1(3), MAPK10(3), MDM2(2), MYC(3), NFKB1(2), NFKBIB(1), PLEKHG5(4), PRF1(3), RELA(1), RIPK1(2), TNFRSF10B(1), TNFRSF21(2), TNFRSF25(2), TRAF2(1), TRAF3(3) 25286744 96 72 96 27 19 23 24 15 15 0 0.195 1.000 1.000 370 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACADVL(4), ACAT2(1), ACOX3(1), ACSL1(2), ACSL3(1), ACSL4(6), ACSL5(4), ACSL6(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CPT1A(4), CPT1B(3), CPT1C(5), CPT2(2), CYP4A11(8), CYP4A22(6), DCI(1), ECHS1(2), EHHADH(2), GCDH(1), HADHA(3), HADHB(2), HSD17B4(3), PECI(1) 22294292 95 72 95 28 9 25 26 21 14 0 0.284 1.000 1.000 371 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(9), COL4A5(7), COL4A6(2), F10(3), F11(2), F12(1), F2(2), F5(12), F8(4), F9(5), FGA(7), FGB(2), FGG(3), KLKB1(5), PROS1(5), SERPINC1(3), SERPING1(3) 20236242 92 72 92 25 6 27 32 13 14 0 0.345 1.000 1.000 372 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(3), AKT3(4), ANKRD6(2), APC(17), AXIN1(5), AXIN2(5), CSNK1A1(1), CTNNB1(2), DACT1(3), DKK1(2), DKK2(3), DKK3(2), DVL1(2), FSTL1(3), GSK3B(1), LRP1(17), MVP(3), NKD1(5), NKD2(1), PIN1(1), PTPRA(4), SENP2(2), SFRP1(1) 18399429 91 72 91 32 9 30 22 18 11 1 0.424 1.000 1.000 373 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(4), ARHGEF11(3), BCL2(1), CDC42(1), DLG4(1), GNA13(1), LPA(8), MAP2K4(1), MAP3K1(3), MAP3K5(5), MAPK8(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PI3(1), PIK3CB(5), PLD1(8), PLD2(1), PLD3(1), PTK2(5), ROCK1(11), ROCK2(5), SERPINA4(6), TBXA2R(1) 22402792 96 71 96 35 9 26 29 15 17 0 0.720 1.000 1.000 374 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 35 CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), ELK1(1), FPR1(3), GNA15(2), GNB1(2), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAPK1(4), MAPK14(1), NCF2(4), NFATC1(7), NFATC2(6), NFATC3(6), NFATC4(2), NFKB1(2), PAK1(1), PIK3C2G(7), PLCB1(12), RAF1(2), RELA(1), SYT1(5) 17034759 86 70 83 25 23 12 29 13 9 0 0.265 1.000 1.000 375 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(3), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2) 22234026 85 70 85 35 16 18 21 14 16 0 0.812 1.000 1.000 376 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(2), AGPAT1(2), AGPAT2(1), AGPAT3(1), AGPAT4(2), AGPS(4), CDIPT(1), CDS1(1), CDS2(3), CHAT(6), CLC(2), CPT1B(3), DGKA(2), DGKB(6), DGKD(4), DGKE(3), DGKH(4), DGKQ(5), DGKZ(4), GNPAT(3), GPD1(1), GPD2(2), LCAT(2), LGALS13(1), PAFAH2(1), PCYT1A(1), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PLCB2(4), PLCG1(5), PLCG2(4), PPAP2B(1) 22761376 87 70 87 26 10 13 25 19 20 0 0.265 1.000 1.000 377 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ACYP1(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GCK(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHB(1), LDHC(3), PDHA1(3), PDHA2(5), PFKM(2), PFKP(3), PGAM1(1), PGM1(3), PGM3(1), PKLR(1), PKM2(3), TPI1(2) 22234026 85 70 85 35 16 18 21 14 16 0 0.812 1.000 1.000 378 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 31 A1BG(4), AKT1(2), AKT2(3), AKT3(4), BAD(1), BTK(5), GSK3B(1), IARS(7), IGFBP1(2), INPP5D(7), PDK1(1), PPP1R13B(1), PTEN(6), RPS6KA1(4), RPS6KA2(4), RPS6KA3(3), RPS6KB1(3), SFN(5), SHC1(1), SOS1(7), SOS2(9), TEC(2), YWHAB(1), YWHAE(2), YWHAG(1), YWHAH(1), YWHAQ(1), YWHAZ(2) 15160750 90 70 90 28 8 23 34 17 8 0 0.402 1.000 1.000 379 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 33 ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), BCR(1), CAPNS1(1), CAPNS2(2), CRKL(1), CSK(1), FYN(3), ITGA1(3), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK8(4), PPP1R12B(1), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SOS1(7), SRC(1), TLN1(13), VCL(6), ZYX(2) 20496513 95 67 92 25 14 18 40 16 7 0 0.202 1.000 1.000 380 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 37 AKT1(2), ATF2(1), CDC42(1), DUSP10(2), DUSP4(1), GAB1(2), GCK(2), IL1R1(2), MAP2K4(1), MAP2K5(2), MAP3K1(3), MAP3K10(4), MAP3K11(1), MAP3K12(6), MAP3K13(8), MAP3K3(1), MAP3K4(5), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK10(3), MAPK7(1), MAPK8(4), MAPK9(4), MYEF2(3), NFATC3(6), NR2C2(1), PAPPA(9), SHC1(1), TRAF6(1), ZAK(2) 22621392 90 67 90 23 11 23 31 13 12 0 0.174 1.000 1.000 381 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 22 ADRB1(1), AKT1(2), APC(17), ASAH1(1), DAG1(1), DLG4(1), EPHB2(2), GNAI1(1), ITPR1(8), ITPR2(11), ITPR3(5), KCNJ3(4), KCNJ5(3), KCNJ9(1), MAPK1(4), PITX2(1), PTX3(2), RHO(3), RYR1(16) 20572470 84 67 81 34 20 19 20 12 13 0 0.646 1.000 1.000 382 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(1), ALDOB(3), ALDOC(1), DLAT(2), ENO1(1), ENO3(1), FBP2(1), G6PC(2), GAPDHS(1), GCK(2), GOT1(1), GOT2(2), GPI(2), HK1(3), HK2(5), HK3(4), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MDH1(1), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PFKL(4), PFKM(2), PFKP(3), PGAM1(1), PGK2(3), PKLR(1), PKM2(3), TNFAIP1(2), TPI1(2) 19321716 82 66 82 31 20 14 24 14 10 0 0.611 1.000 1.000 383 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(3), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), FUK(1), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), LHPP(1), MPI(3), MTMR2(5), MTMR6(2), PFKFB1(4), PFKFB2(4), PFKFB4(2), PFKL(4), PFKM(2), PFKP(3), PGM2(1), PHPT1(1), RDH11(1), RDH12(3), SORD(1), TPI1(2), TSTA3(2) 16906477 72 66 72 19 17 9 25 12 9 0 0.154 1.000 1.000 384 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAD(2), ALAS2(4), BLVRA(2), COX10(1), COX15(2), CP(4), CPOX(1), EARS2(1), EPRS(2), FECH(1), FTMT(4), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4), UROD(1), UROS(3) 19248154 84 66 84 34 7 14 40 20 3 0 0.908 1.000 1.000 385 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(2), B3GALT1(1), B3GALT2(1), B3GALT4(3), B3GALT5(1), B3GNT1(1), B3GNT2(1), B3GNT3(4), B3GNT5(2), B4GALNT1(2), B4GALT2(3), B4GALT6(2), FUT1(1), FUT2(2), FUT5(3), FUT6(1), FUT9(10), GBGT1(2), GCNT2(4), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(5), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1), ST3GAL5(2), ST3GAL6(1), ST6GALNAC3(5), ST6GALNAC5(2), ST6GALNAC6(3), ST8SIA1(2), ST8SIA5(4), UGCG(1) 22103183 86 66 86 32 11 21 29 13 12 0 0.512 1.000 1.000 386 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 70 CALR(2), CD74(2), CD8A(2), CD8B(1), CIITA(5), CREB1(1), CTSS(3), HLA-C(3), HLA-DMB(1), HLA-DOA(1), HLA-DQA2(2), HLA-DQB1(1), HLA-DRA(1), HLA-F(2), HSP90AA1(6), HSP90AB1(7), HSPA5(3), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), KIR2DL1(3), KIR2DL3(1), KIR2DS4(1), KIR3DL1(7), KIR3DL3(2), KLRC2(1), KLRC3(2), KLRC4(1), LGMN(3), LTA(1), NFYC(2), PSME1(1), PSME2(1), RFX5(4), RFXAP(1), TAP1(3), TAP2(5), TAPBP(1) 20384956 92 66 92 34 9 25 26 15 16 1 0.504 1.000 1.000 387 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(8), AR(3), ESR1(3), ESR2(1), ESRRA(4), HNF4A(2), NPM1(1), NR0B1(3), NR1D1(1), NR1D2(2), NR1I2(2), NR2C2(1), NR2E1(3), NR2F1(2), NR2F2(4), NR3C1(5), NR4A2(2), NR5A2(2), PGR(2), RARA(2), RARB(2), RARG(5), ROR1(5), RORA(1), RORC(2), RXRA(4), RXRB(2), RXRG(6), THRA(5), THRB(1), VDR(1) 19120352 87 66 85 32 18 13 30 11 15 0 0.669 1.000 1.000 388 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(2), ARHGAP4(5), ARHGAP5(6), ARHGAP6(6), ARHGEF1(5), ARHGEF11(3), ARHGEF5(3), ARPC1B(1), ARPC2(2), ARPC4(1), CFL1(2), DIAPH1(6), GSN(5), LIMK1(5), MYLK(4), PIP5K1A(4), PIP5K1B(4), PPP1R12B(1), ROCK1(11), SRC(1), TLN1(13), VCL(6) 20642161 97 66 97 35 11 26 32 22 6 0 0.621 1.000 1.000 389 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(3), ACY3(3), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(2), ALDH9A1(2), AMDHD1(2), AOC2(2), AOC3(5), ASPA(1), CARM1(3), CNDP1(3), DDC(7), FTCD(1), HAL(2), HARS2(1), HDC(2), HEMK1(1), LCMT1(1), LCMT2(6), MAOA(1), MAOB(1), METTL2B(2), METTL6(2), PRMT3(3), PRMT5(2), PRMT6(2), PRMT7(2), PRMT8(2), PRPS1(3), PRPS2(1), UROC1(3) 18011757 77 65 77 20 16 22 24 5 10 0 0.0515 1.000 1.000 390 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 31 ACVR1(5), APC(17), ATF2(1), AXIN1(5), BMP10(1), BMP2(3), BMP4(2), BMP5(2), BMP7(3), BMPR2(3), CHRD(6), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MEF2C(7), NKX2-5(1), NPPA(1), NPPB(1), RFC1(2), TGFB1(1), TGFB2(2), TGFBR1(1), TGFBR3(3), WNT1(1) 16089237 80 64 80 20 7 21 26 15 10 1 0.163 1.000 1.000 391 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 20 ATM(9), ATR(18), BRCA1(9), BRCA2(11), CHEK2(4), FANCA(4), FANCC(2), FANCD2(2), FANCG(2), HUS1(2), MRE11A(1), RAD17(3), RAD50(5), RAD51(1), TREX1(2) 19690872 75 64 75 15 6 23 16 21 9 0 0.0824 1.000 1.000 392 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 26 CASP10(2), CASP3(1), CASP6(2), CASP7(1), CFLAR(2), FADD(1), FAF1(1), LMNB1(1), LMNB2(4), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), PTPN13(9), RB1(10), RIPK2(1), SPTAN1(11) 18064122 79 64 79 22 14 14 22 9 20 0 0.448 1.000 1.000 393 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 20 ATM(9), ATR(18), BRCA1(9), CCNB1(3), CDC25B(3), CDC34(1), CHEK2(4), MDM2(2), MYT1(7), PRKDC(15), RPS6KA1(4), WEE1(1), YWHAH(1), YWHAQ(1) 16478112 78 63 78 19 9 16 22 20 11 0 0.261 1.000 1.000 394 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(2), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2F1(3), GTF2H1(2), GTF2H3(2), GTF2H4(1), GTF2I(3), GTF2IRD1(3), TAF1(8), TAF10(4), TAF1L(13), TAF2(5), TAF4(2), TAF4B(4), TAF5(5), TAF5L(1), TAF6(3), TAF7(1), TAF7L(2), TAF9(2), TBPL1(2), TBPL2(1) 16412255 76 63 76 25 6 20 24 13 13 0 0.620 1.000 1.000 395 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 31 ACTR2(1), AKT1(2), ANGPTL2(2), DAG1(1), DGKA(2), ETFA(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), MAP2K1(4), MAPK1(4), PAK1(1), PDE3A(12), PDE3B(1), PI3(1), PIK3C2G(7), PIK3CD(2), PIK3R1(6), PLDN(2), PSME1(1), SGCB(3), VASP(1) 21095391 86 63 83 25 13 17 24 14 18 0 0.313 1.000 1.000 396 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(4), AKT1(2), AKT2(3), AKT3(4), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(9), PIK3CB(5), PITX2(1), PLD1(8), PLD2(1), PLD3(1), VN1R1(1) 20370491 75 63 75 32 8 25 15 13 14 0 0.734 1.000 1.000 397 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 30 AGT(2), ATF2(1), CALM1(1), CALM3(1), EGFR(14), ELK1(1), MAP2K1(4), MAP2K2(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), MEF2A(1), MEF2B(2), MEF2C(7), PAK1(1), PRKCA(2), PTK2(5), PTK2B(2), RAF1(2), SHC1(1), SOS1(7), SRC(1), SYT1(5) 14513970 75 62 72 22 11 11 31 14 8 0 0.425 1.000 1.000 398 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 36 AGT(2), AGTR2(2), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), F2(2), FYN(3), GNAI1(1), GNB1(2), JAK2(2), MAP2K1(4), MAP2K2(3), MAPK1(4), MAPK14(1), MAPK8(4), MAPT(6), MYLK(4), PLCG1(5), PRKCA(2), PTK2B(2), RAF1(2), SHC1(1), SOS1(7), STAT1(5), STAT3(3), STAT5A(1), SYT1(5) 18723969 81 61 77 22 13 16 30 14 8 0 0.161 1.000 1.000 399 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(5), ACACA(11), ACACB(12), ACADM(3), ACAT2(1), ACSS1(5), ACSS2(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), HIBCH(1), LDHA(1), LDHAL6B(4), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3) 18088116 76 61 76 26 16 15 23 12 10 0 0.601 1.000 1.000 400 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(11), ACAT2(1), ACYP1(1), ADH5(2), AKR1B1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), DLAT(2), GLO1(1), HAGH(1), LDHA(1), LDHB(1), LDHC(3), LDHD(3), MDH1(1), ME1(2), ME2(1), ME3(6), PC(7), PDHA1(3), PDHA2(5), PKLR(1), PKM2(3) 16825998 69 61 69 25 20 13 16 14 6 0 0.591 1.000 1.000 401 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AACS(1), AADAC(2), ABAT(5), ACADS(2), ACAT2(1), ACSM1(2), AKR1B10(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BDH1(1), BDH2(1), DDHD1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), ILVBL(3), L2HGDH(4), OXCT1(1), OXCT2(1), PDHA1(3), PDHA2(5), PLA1A(5), PRDX6(1), RDH11(1), RDH12(3) 18485529 73 60 73 32 11 16 24 14 8 0 0.875 1.000 1.000 402 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(3), CARS(2), DARS(2), DARS2(1), EARS2(1), EPRS(2), FARS2(2), FARSB(4), GARS(1), HARS2(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), MTFMT(3), NARS(2), NARS2(1), PARS2(3), QARS(1), RARS(1), RARS2(3), SARS(1), SARS2(2), TARS(3), TARS2(1), VARS(5), VARS2(1), WARS2(5), YARS(3), YARS2(3) 24731006 74 60 73 28 8 15 30 15 6 0 0.788 1.000 1.000 403 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 25 AKT1(2), AKT2(3), AKT3(4), CISH(1), IARS(7), IL13RA1(1), IL4(1), IL4R(2), INPP5D(7), JAK1(6), JAK2(2), JAK3(3), NR0B2(1), PI3(1), PPP1R13B(1), RPS6KB1(3), SERPINA4(6), SHC1(1), SOS1(7), SOS2(9), SRC(1), STAT6(2), TYK2(2) 15801041 73 60 73 29 8 19 28 13 5 0 0.753 1.000 1.000 404 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 14 AKT1(2), BCL2(1), EGFR(14), IGF1R(7), MYC(3), POLR2A(9), PRKCA(2), RB1(10), TEP1(8), TERF1(3), TERT(1), TNKS(4), XRCC5(2) 12493643 66 60 66 24 8 14 21 11 12 0 0.503 1.000 1.000 405 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(3), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), AOX1(5), DBH(4), DCT(1), DDC(7), FAH(1), GOT1(1), GOT2(2), HGD(2), HPD(1), MAOA(1), MAOB(1), PNMT(1), TAT(1), TH(2), TPO(10), TYR(4) 14444053 70 60 69 27 11 19 22 7 11 0 0.585 1.000 1.000 406 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 46 APAF1(9), BAD(1), BAX(1), BCL2(1), BCL2A1(1), BCL2L1(2), CASP1(2), CASP10(2), CASP3(1), CASP4(1), CASP6(2), CASP7(1), CD40(4), CD40LG(3), CRADD(1), FADD(1), FAS(1), FASLG(1), IKBKE(1), LTA(1), MCL1(1), NFKB1(2), NGFR(1), NR3C1(5), NTRK1(3), PTPN13(9), RIPK1(2), SFRS2IP(5), TFG(1), TRAF2(1), TRAF3(3), TRAF6(1) 19294570 71 59 71 22 16 15 16 15 9 0 0.338 1.000 1.000 407 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 19 F10(3), F11(2), F12(1), F2(2), F5(12), F7(2), F8(4), F9(5), FGA(7), FGB(2), FGG(3), LPA(8), PLAT(2), PLAU(1), PLG(8), SERPINB2(2), SERPINE1(4), VWF(6) 15461994 74 59 74 19 6 17 24 13 14 0 0.158 1.000 1.000 408 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 20 CCR3(3), CFL1(2), GNAS(6), GNB1(2), LIMK1(5), MAP2K1(4), MAPK1(4), NOX1(5), PIK3C2G(7), PLCB1(12), PPP1R12B(1), PRKCA(2), PTK2(5), RAF1(2), ROCK2(5) 11249653 65 59 62 19 15 13 23 6 8 0 0.438 1.000 1.000 409 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC6(2), CDC7(1), CDT1(1), DIAPH2(6), GMNN(1), MCM10(1), MCM2(4), MCM3(2), MCM4(4), MCM5(2), MCM6(3), MCM7(5), NACA(3), ORC2L(1), ORC4L(1), ORC5L(1), ORC6L(1), POLA2(2), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), RFC1(2), RFC2(2), RFC3(1), RFC4(4), RFC5(2), RPA1(4), RPS27A(1), UBA52(2), UBB(1), UBC(4) 23074021 80 59 79 35 8 20 34 7 11 0 0.955 1.000 1.000 410 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 19 ARHGAP5(6), DIAPH1(6), FYN(3), GSN(5), ITGA1(3), MAP2K1(4), MAPK1(4), MYLK(4), PIK3R1(6), PTK2(5), PXN(1), RAF1(2), ROCK1(11), SHC1(1), SRC(1), TLN1(13) 15035733 75 59 72 19 10 13 23 21 8 0 0.278 1.000 1.000 411 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(2), GPRC5B(2), GPRC5C(2), GRM1(16), GRM2(4), GRM3(13), GRM4(2), GRM5(7), GRM7(8), GRM8(12) 9519867 71 59 71 23 16 15 25 13 2 0 0.132 1.000 1.000 412 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(6), ADRBK2(4), ARRB2(1), CALM1(1), CALM3(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), CLCA1(5), CLCA2(2), CLCA4(2), CNGA3(4), CNGA4(3), CNGB1(9), GNAL(2), PDC(1), PDE1C(9), PRKACA(4), PRKACB(2), PRKACG(1), PRKG1(3), PRKG2(1), PRKX(1) 13896049 68 59 68 27 13 13 18 16 8 0 0.653 1.000 1.000 413 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 32 ADRA1A(4), ADRA1B(1), ADRA2C(1), ADRB1(1), ADRB3(2), CHRM2(4), CHRM3(5), CHRM5(1), DRD1(1), DRD2(2), DRD3(4), DRD4(1), DRD5(7), HRH1(1), HRH2(1), HTR1A(6), HTR1B(3), HTR1E(7), HTR1F(4), HTR2A(3), HTR2B(1), HTR2C(1), HTR4(1), HTR5A(3), HTR6(3), HTR7(3) 11657802 71 59 71 34 15 10 25 16 5 0 0.745 1.000 1.000 414 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 27 BAG4(4), CASP3(1), CRADD(1), FADD(1), LMNB1(1), LMNB2(4), MADD(6), MAP2K4(1), MAP3K1(3), MAP3K7(4), MAPK8(4), PAK1(1), PAK2(5), PRKDC(15), RB1(10), RIPK1(2), SPTAN1(11), TRAF2(1) 17178194 75 59 75 20 13 11 26 8 17 0 0.391 1.000 1.000 415 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 23 ARNT(4), EIF1(2), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(3), ELAVL1(1), FLT1(10), FLT4(6), HIF1A(2), KDR(5), NOS3(4), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PXN(1), SHC1(1) 14281196 64 59 64 22 15 12 22 7 8 0 0.648 1.000 1.000 416 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), CYP19A1(1), CYP1A2(4), CYP2A13(2), CYP2A7(2), CYP2B6(3), CYP2C18(1), CYP2C19(3), CYP2C8(3), CYP2C9(5), CYP2D6(1), CYP2E1(5), CYP2F1(2), CYP2J2(4), CYP3A4(3), CYP3A5(1), CYP3A7(1), CYP4B1(2), CYP4F8(3), PON1(6) 13347882 69 58 69 20 10 11 28 13 7 0 0.273 1.000 1.000 417 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(2), C1GALT1(3), C1GALT1C1(2), GALNT1(2), GALNT10(2), GALNT11(2), GALNT12(3), GALNT13(7), GALNT14(5), GALNT2(3), GALNT3(3), GALNT4(2), GALNT5(4), GALNT6(3), GALNT8(5), GALNTL1(3), GALNTL2(3), GALNTL4(1), GALNTL5(4), GCNT1(1), GCNT4(2), OGT(3), ST3GAL1(1), ST6GALNAC1(4), WBSCR17(8) 14694128 79 58 79 27 14 16 23 11 15 0 0.585 1.000 1.000 418 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 40 ARNTL(1), AZIN1(1), BTG1(1), CBX3(1), CEBPB(1), CLOCK(4), CRY1(3), CRY2(1), DAZAP2(1), DNAJA1(1), EIF4G2(3), ETV6(4), G0S2(1), GFRA1(6), HERPUD1(3), HSPA8(3), IDI1(1), KLF9(1), MYF6(1), NCKAP1(5), NCOA4(2), NR1D2(2), PER1(5), PER2(2), PPP1R3C(1), PPP2CB(1), TUBB3(2), UCP3(3), UGP2(1), VAPA(1), ZFR(3) 16654955 66 57 66 25 9 13 27 10 7 0 0.818 1.000 1.000 419 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 23 POLA1(2), POLA2(2), POLB(1), POLD1(3), POLD2(1), POLD3(3), POLE(8), POLE2(1), POLG(2), POLG2(1), POLH(2), POLI(2), POLK(3), POLL(5), POLM(1), POLQ(16), REV1(1), REV3L(11), RFC5(2) 18056685 67 57 67 23 9 18 18 9 13 0 0.600 1.000 1.000 420 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AADAT(1), AASDH(3), AASDHPPT(3), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BBOX1(1), DLST(4), DOT1L(3), ECHS1(2), EHHADH(2), EHMT1(6), EHMT2(6), GCDH(1), HADHA(3), PLOD1(3), PLOD2(7), PLOD3(4), SHMT1(1), SHMT2(2), TMLHE(2) 16863752 66 56 66 31 13 13 17 12 11 0 0.887 1.000 1.000 421 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 22 ACTA1(2), CAPN2(4), CAPNS1(1), CAPNS2(2), CXCR3(1), EGF(6), EGFR(14), ITGA1(3), MAPK1(4), MYLK(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PTK2(5), PXN(1), TLN1(13) 13899193 68 56 65 26 12 11 24 13 8 0 0.747 1.000 1.000 422 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 25 ATM(9), BMPR1B(1), CDK4(4), CDKN1B(2), CEBPB(1), DMC1(2), EGR1(3), ESR2(1), FSHR(5), INHA(1), LHCGR(2), MLH1(4), MSH5(1), NCOR1(12), NRIP1(4), PGR(2), PRLR(4), PTGER2(4), SMPD1(1), VDR(1), ZP2(4) 15955331 68 56 66 18 7 15 24 13 9 0 0.277 1.000 1.000 423 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(6), ATP4B(2), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ATP7A(8), ATP7B(4), COX10(1), COX5B(1), COX8A(1), NDUFA5(3), NDUFB4(1), NDUFB6(1), NDUFS1(1), NDUFS2(1), NDUFV1(1), SDHA(4), SHMT1(1), UQCRC1(1), UQCRFS1(3) 17384861 62 56 62 20 6 18 16 15 7 0 0.368 1.000 1.000 424 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(5), ACAA2(1), ACADM(3), ACADS(2), ACAT2(1), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOX1(5), AUH(1), BCAT2(1), BCKDHA(1), BCKDHB(1), DBT(5), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HIBCH(1), HMGCL(1), HMGCS1(2), HMGCS2(2), HSD17B4(3), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), OXCT2(1), PCCA(5), PCCB(1) 19616344 67 55 67 23 12 18 18 11 8 0 0.567 1.000 1.000 425 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(5), ACACA(11), ACADL(2), ACADM(3), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), HADHA(3), LDHA(1), LDHB(1), LDHC(3), MLYCD(1), MUT(2), PCCA(5), PCCB(1), SUCLA2(1), SUCLG2(3) 15097273 60 55 60 17 13 11 18 9 9 0 0.360 1.000 1.000 426 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ACTG2(3), ADCY3(6), ADCY9(4), AK1(1), ARF4(1), ARF6(2), ARL4D(1), ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V0D2(3), ATP6V1A(1), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1E2(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), ERO1L(2), GNAS(6), PLCG1(5), PLCG2(4), PRKCA(2), SEC61A1(3), SEC61A2(2), SEC61B(1), TRIM23(1) 16815893 68 54 68 20 13 13 22 11 9 0 0.232 1.000 1.000 427 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 ERCC3(4), GTF2A2(1), GTF2B(1), GTF2E1(5), GTF2H1(2), GTF2H4(1), ILK(4), MNAT1(2), POLR1A(5), POLR1B(3), POLR2A(9), POLR2B(3), POLR2G(2), POLR2H(1), POLR3B(2), POLR3D(1), POLR3E(1), POLR3H(1), TAF5(5), TAF6(3), TAF7(1), TAF9(2), TBP(1) 15971986 60 54 60 24 8 15 17 7 13 0 0.782 1.000 1.000 428 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 31 MAP2K4(1), MAPK1(4), MAPK10(3), MAPK11(2), MAPK12(1), MAPK13(3), MAPK14(1), MAPK8(4), MAPK8IP1(3), MAPK8IP2(2), MAPK8IP3(5), MAPK9(4), MAPKAPK5(1), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), PIK3CD(2), PIK3R1(6), SYT1(5), TRAF2(1), TRAF3(3), TRAF5(1), TRAF6(1) 14336108 58 54 55 19 13 8 18 9 10 0 0.453 1.000 1.000 429 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(1), RPE(1), UGDH(3), UGP2(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2A1(4), UGT2A3(4), UGT2B10(11), UGT2B11(7), UGT2B15(2), UGT2B28(3), UGT2B4(8), UGT2B7(4), XYLB(2) 12441231 63 53 63 22 7 10 27 16 3 0 0.733 1.000 1.000 430 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(3), ABAT(5), ACY3(3), ADSL(4), ADSS(2), ADSSL1(2), AGXT2(2), ASNS(4), ASPA(1), ASRGL1(1), ASS1(1), CAD(2), DARS(2), DARS2(1), DLAT(2), GAD1(2), GAD2(2), GOT1(1), GOT2(2), GPT2(2), NARS(2), NARS2(1), PC(7), PDHA1(3), PDHA2(5) 17243718 63 53 63 29 11 18 21 8 5 0 0.843 1.000 1.000 431 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 27 ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), ESCO1(3), ESCO2(3), GOT1(1), GOT2(2), HPD(1), MAOA(1), MAOB(1), MPO(5), MYST3(4), MYST4(6), PRDX6(1), SH3GLB1(2), TAT(1), TPO(10) 15581425 66 53 65 32 12 13 27 5 9 0 0.941 1.000 1.000 432 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 20 CFL1(2), CHN1(3), LIMK1(5), MAP3K1(3), MYLK(4), NCF2(4), PAK1(1), PDGFRA(6), PIK3R1(6), PLD1(8), PPP1R12B(1), RALBP1(2), RPS6KB1(3), TRIO(10), VAV1(2), WASF1(3) 14729949 63 53 63 32 7 17 24 8 7 0 0.981 1.000 1.000 433 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(17), AXIN1(5), BTRC(1), CCND1(2), CREBBP(15), CSNK1A1(1), CSNK2A1(6), CTBP1(1), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), MAP3K7(4), MYC(3), NLK(1), TLE1(4), WNT1(1) 13396234 69 53 69 20 4 16 24 9 15 1 0.461 1.000 1.000 434 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(3), AGMAT(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH4A1(1), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), GATM(2), GLUD1(2), GOT1(1), GOT2(2), MAOA(1), MAOB(1), NOS1(3), NOS3(4), ODC1(1), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), P4HB(1), PYCR1(1), RARS(1), SMS(2) 20123489 67 52 67 26 16 16 18 11 6 0 0.607 1.000 1.000 435 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 29 AKT1(2), AVP(1), CABIN1(7), CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), HDAC5(1), IGF1R(7), INSR(2), MAP2K6(1), MAPK14(1), MAPK7(1), MEF2A(1), MEF2B(2), MEF2C(7), NFATC1(7), NFATC2(6), PIK3R1(6), SYT1(5), YWHAH(1) 14886501 62 52 62 25 10 14 18 14 6 0 0.620 1.000 1.000 436 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(5), ABP1(3), ACADL(2), ACADM(3), ACADSB(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), MLYCD(1), SMS(2), UPB1(1) 13246982 64 51 64 20 10 17 18 9 10 0 0.361 1.000 1.000 437 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 37 ATF2(1), CDC42(1), CREB1(1), ELK1(1), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K5(5), MAP3K7(4), MAP3K9(2), MAPK14(1), MAPKAPK5(1), MAX(1), MEF2A(1), MEF2B(2), MEF2C(7), MKNK1(1), MYC(3), PLA2G4A(3), RIPK1(2), RPS6KA5(4), SHC1(1), STAT1(5), TGFB1(1), TGFB2(2), TGFBR1(1), TRAF2(1) 16271579 57 51 57 23 7 14 21 5 10 0 0.807 1.000 1.000 438 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 22 ATF2(1), BCR(1), BLNK(3), ELK1(1), FOS(1), LYN(3), MAP2K1(4), MAP3K1(3), MAPK1(4), MAPK8IP3(5), PAPPA(9), RPS6KA1(4), RPS6KA3(3), SHC1(1), SOS1(7), SYK(2), VAV1(2), VAV2(1), VAV3(1) 14224894 56 51 53 17 14 9 16 8 9 0 0.409 1.000 1.000 439 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 14 ACTA1(2), ACTN1(2), ACTN2(6), ACTN3(6), CAPNS1(1), CAPNS2(2), ITGA1(3), ITGB3(5), PTK2(5), PXN(1), SPTAN1(11), SRC(1), TLN1(13) 12004985 58 51 58 17 10 7 27 10 4 0 0.479 1.000 1.000 440 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 19 AKT1(2), APAF1(9), ATM(9), BAD(1), BAX(1), BCL2(1), BCL2L1(2), BID(2), CASP3(1), CASP6(2), CASP7(1), EIF2S1(1), PRKCA(2), PTK2(5), PXN(1), STAT1(5), TLN1(13) 12104801 58 50 58 21 7 13 19 11 8 0 0.739 1.000 1.000 441 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(3), AGXT2(2), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CPT1B(3), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PLCB2(4), PLCG1(5), PLCG2(4), SARDH(5), SARS(1), SHMT1(1), SHMT2(2), TARS(3) 19087059 61 50 61 29 12 12 25 5 7 0 0.845 1.000 1.000 442 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 25 AKT1(2), APC(17), AXIN1(5), CCND1(2), CD14(1), CTNNB1(2), DVL1(2), FZD1(3), GJA1(1), GNAI1(1), GSK3B(1), IRAK1(1), LBP(7), LEF1(2), LY96(1), NFKB1(2), PDPK1(2), PIK3R1(6), RELA(1), TLR4(7), WNT1(1) 13050542 67 50 67 23 8 18 19 12 9 1 0.530 1.000 1.000 443 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(5), DLG4(1), EPHB2(2), F2(2), F2RL1(1), F2RL2(1), F2RL3(3), MAP2K5(2), MAPK1(4), MAPK7(1), MAPK8(4), MYEF2(3), PLD1(8), PLD2(1), PLD3(1), PTK2(5), RAF1(2), RASAL1(5), SRC(1), TEC(2), VAV1(2) 12511791 56 50 53 18 7 10 18 8 13 0 0.532 1.000 1.000 444 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 EEF1A2(2), EEF2(1), EEF2K(4), EIF2AK1(6), EIF2AK3(1), EIF2B2(1), EIF2B3(3), EIF2B5(2), EIF2S1(1), EIF2S2(3), EIF4A1(1), EIF4EBP1(1), EIF4G1(12), EIF4G3(4), EIF5(2), EIF5B(3), ETF1(2), GSPT2(4), KIAA0664(4), PABPC3(3), PAIP1(4) 19913415 64 50 64 20 8 10 23 12 11 0 0.699 1.000 1.000 445 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 ACO2(2), CS(2), DLAT(2), DLST(4), FH(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), PC(7), PDHA1(3), PDHA2(5), PDHX(4), PDK1(1), PDK4(4), SDHA(4), SDHC(1), SUCLA2(1), SUCLG2(3) 12919449 54 49 54 21 7 11 20 9 7 0 0.740 1.000 1.000 446 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(4), GTF2A1(2), GTF2B(1), GTF2E1(5), GTF2F1(3), HDAC3(1), NCOA1(4), NCOA2(3), NCOA3(4), NCOR2(11), POLR2A(9), RARA(2), RXRA(4), TBP(1) 11377258 54 49 54 16 7 12 22 8 5 0 0.394 1.000 1.000 447 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 26 AKT1(2), AKT2(3), AKT3(4), BAD(1), BCL2(1), GSK3B(1), IL4R(2), IRS1(1), IRS2(2), JAK1(6), JAK3(3), MAP4K1(2), MAPK1(4), PDK1(1), PIK3CD(2), PIK3R1(6), PPP1R13B(1), RAF1(2), SHC1(1), SOS1(7), SOS2(9), STAT6(2) 15667205 63 49 60 23 10 15 21 12 5 0 0.565 1.000 1.000 448 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACAA2(1), ACADL(2), ACADM(3), ACADS(2), ACADSB(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), AOX1(5), BCKDHA(1), BCKDHB(1), ECHS1(2), EHHADH(2), HADHA(3), HADHB(2), HIBADH(1), HMGCL(1), IVD(1), MCCC1(1), MCCC2(3), MUT(2), OXCT1(1), PCCA(5), PCCB(1) 16411285 54 49 54 20 8 12 16 8 10 0 0.723 1.000 1.000 449 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(5), ADC(1), ALDH4A1(1), CAD(2), CPS1(11), EARS2(1), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GFPT2(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), GMPS(4), GNPNAT1(1), GOT1(1), GOT2(2), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1) 18015965 59 48 59 30 11 14 17 14 3 0 0.950 1.000 1.000 450 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CD14(1), CHUK(3), ELK1(1), FOS(1), IKBKB(5), IRAK1(1), LY96(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TLR2(1), TLR3(1), TLR4(7), TLR6(3), TLR7(4), TLR9(2), TRAF6(1) 16629202 54 48 54 21 8 8 24 7 7 0 0.814 1.000 1.000 451 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(6), OGDHL(9), PC(7), PCK2(2), SDHA(4), SDHC(1), SUCLA2(1), SUCLG2(3) 13606372 55 47 55 18 7 11 17 13 7 0 0.464 1.000 1.000 452 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAA2(1), ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), AKR1B10(3), AKR1C4(2), AKR1D1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), LIPA(1), RDH11(1), RDH12(3), SLC27A5(2), SOAT1(3), SOAT2(2), SRD5A2(2) 14411602 58 47 58 20 9 14 22 8 5 0 0.514 1.000 1.000 453 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(3), AGXT2(2), AKR1B10(3), ALAS2(4), AOC2(2), AOC3(5), CHDH(2), CTH(2), DMGDH(2), GARS(1), GATM(2), GCAT(3), GLDC(3), MAOA(1), MAOB(1), PHGDH(1), PIPOX(1), RDH11(1), RDH12(3), SARDH(5), SARS(1), SARS2(2), SHMT1(1), SHMT2(2), TARS(3), TARS2(1) 19401255 57 47 57 25 11 12 25 3 6 0 0.746 1.000 1.000 454 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(5), ABP1(3), ACADM(3), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), CNDP1(3), DPYD(8), DPYS(5), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HIBCH(1), MLYCD(1), SMS(2), UPB1(1) 12311011 57 47 57 19 9 17 15 9 7 0 0.410 1.000 1.000 455 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 ARSB(1), FUCA1(1), GALNS(1), GBA(2), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NAGLU(1), NEU1(1), NEU2(1), SPAM1(2) 15650075 50 47 50 20 10 10 12 11 7 0 0.654 1.000 1.000 456 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM1(1), CALM3(1), DLG4(1), GRIN2A(14), GRIN2B(15), GRIN2C(4), GRIN2D(3), NOS1(3), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), PRKCA(2), SYT1(5) 11640690 57 47 57 23 11 15 18 10 3 0 0.588 1.000 1.000 457 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG1(2), ALG10(2), ALG10B(3), ALG12(2), ALG13(2), ALG2(2), ALG3(1), ALG5(1), ALG6(2), ALG9(1), B4GALT2(3), DHDDS(2), DOLPP1(1), DPAGT1(1), DPM1(2), FUT8(2), GANAB(1), MAN1B1(3), MAN1C1(3), MAN2A1(2), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(3), MGAT5(1), MGAT5B(2), RFT1(1), RPN1(1), RPN2(2), STT3B(2) 19334839 56 46 56 23 10 7 21 9 9 0 0.802 1.000 1.000 458 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), FPGT(3), GCK(2), GMDS(1), GMPPA(1), HK1(3), HK2(5), HK3(4), KHK(2), MPI(3), PFKFB1(4), PFKFB4(2), PFKM(2), PFKP(3), SORD(1), TPI1(2) 10869121 46 45 46 14 9 7 17 7 6 0 0.341 1.000 1.000 459 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 20 CHUK(3), CREBBP(15), IKBKB(5), IL1B(1), MAP2K3(3), MAP2K6(1), MAP3K14(2), MAP3K7(4), MAPK11(2), MAPK14(1), NFKB1(2), NR3C1(5), RELA(1), TGFBR1(1), TLR2(1) 10761404 47 45 47 14 4 10 18 8 7 0 0.538 1.000 1.000 460 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(2), ACTN2(6), ACTN3(6), BCAR1(2), CSK(1), CTNNA1(5), CTNNA2(19), CTNNB1(2), PTK2(5), PXN(1), SRC(1), VCL(6) 8727281 56 44 56 23 5 11 23 8 8 1 0.870 1.000 1.000 461 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 21 BCAR1(2), CRK(1), CXCL12(1), CXCR4(1), GNAI1(1), GNB1(2), MAP2K1(4), MAPK1(4), NFKB1(2), PIK3C2G(7), PIK3R1(6), PLCG1(5), PRKCA(2), PTK2(5), PTK2B(2), PXN(1), RAF1(2), RELA(1) 11412455 49 44 46 17 11 8 14 7 9 0 0.653 1.000 1.000 462 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), ASAH1(1), B4GALT6(2), CERK(2), DEGS1(1), DEGS2(1), ENPP7(3), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SGMS1(1), SGMS2(1), SGPP1(2), SMPD1(1), SMPD2(1), SMPD3(1), SMPD4(3), SPHK2(1), SPTLC1(1), SPTLC2(2), UGCG(1) 16282181 50 44 50 19 9 12 12 10 7 0 0.504 1.000 1.000 463 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 13 APC(17), AXIN1(5), CREBBP(15), CTNNB1(2), DVL1(2), FZD1(3), GSK3B(1), LDB1(1), LEF1(2), PITX2(1), TRRAP(10), WNT1(1) 12878986 60 44 60 17 6 16 18 11 8 1 0.299 1.000 1.000 464 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX12(2), ALOX15(1), ALOX5(2), CBR3(1), CYP4F2(3), CYP4F3(1), EPX(5), GGT1(1), MPO(5), PLA2G3(2), PLA2G4A(3), PLA2G6(1), PRDX2(1), PRDX6(1), PTGES2(1), PTGIS(3), PTGS1(6), PTGS2(2), TBXAS1(5), TPO(10) 12736158 56 44 55 25 13 10 19 8 6 0 0.719 1.000 1.000 465 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 AKR1C4(2), AKR1D1(2), ARSB(1), ARSD(1), ARSE(1), CYP11B1(4), CYP11B2(3), HSD11B2(1), HSD17B3(1), HSD17B8(1), HSD3B1(2), HSD3B2(2), SRD5A2(2), STS(1), SULT1E1(3), SULT2A1(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8) 12401080 49 43 49 24 9 8 19 10 3 0 0.930 1.000 1.000 466 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 39 APAF1(9), BAX(1), BCL2(1), BCL2L1(2), BID(2), BIRC2(1), BIRC3(1), CASP3(1), CASP6(2), CASP7(1), FADD(1), FAS(1), FASLG(1), GZMB(1), MAP2K4(1), MAP3K1(3), MAP3K14(2), MAPK10(3), MCL1(1), MDM2(2), MYC(3), NFKB1(2), PARP1(3), PRF1(3), RELA(1), RIPK1(2), TRAF2(1) 16178980 52 43 52 16 11 10 15 10 6 0 0.361 1.000 1.000 467 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(4), ASRGL1(1), CA1(1), CA12(1), CA14(2), CA2(1), CA3(3), CA4(4), CA5A(1), CA5B(1), CA6(3), CA8(3), CPS1(11), CTH(2), GLS(1), GLS2(1), GLUD1(2), GLUD2(4), GLUL(2), HAL(2) 9675351 50 43 50 15 11 13 12 12 2 0 0.352 1.000 1.000 468 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 16 ACE(5), ACE2(1), AGT(2), AGTR2(2), CMA1(3), CPA3(2), CTSG(1), ENPEP(11), LNPEP(2), MAS1(2), MME(11), NLN(2), REN(3) 9310203 47 43 47 19 8 4 23 7 5 0 0.804 1.000 1.000 469 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(3), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(5), DDC(7), EPX(5), GOT1(1), GOT2(2), HPD(1), MAOA(1), MAOB(1), MPO(5), PRDX2(1), PRDX6(1), TAT(1), TPO(10) 10002009 49 43 48 23 11 10 19 3 6 0 0.745 1.000 1.000 470 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 26 BCAR1(2), CALM1(1), CALM3(1), CRKL(1), MAP2K1(4), MAP2K2(3), MAP2K3(3), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK14(1), MAPK8(4), PAK1(1), PLCG1(5), PRKCA(2), PTK2B(2), RAF1(2), SHC1(1), SOS1(7), SRC(1), SYT1(5) 12589092 54 43 51 16 13 7 20 8 6 0 0.442 1.000 1.000 471 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(9), COL4A5(7), COL4A6(2), P4HB(1), SLC23A1(3), SLC23A2(5), SLC2A1(3), SLC2A3(2) 11395523 49 43 49 21 4 18 16 6 5 0 0.899 1.000 1.000 472 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 11 ACE2(1), AGT(2), AGTR2(2), CMA1(3), COL4A1(6), COL4A2(4), COL4A3(7), COL4A4(9), COL4A5(7), COL4A6(2), REN(3) 11167264 46 42 46 21 4 15 18 4 5 0 0.963 1.000 1.000 473 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(5), ALDH4A1(1), CAD(2), CPS1(11), EPRS(2), GAD1(2), GAD2(2), GCLM(1), GFPT1(2), GLS(1), GLS2(1), GLUD1(2), GLUL(2), GMPS(4), GOT1(1), GOT2(2), GPT2(2), GSS(2), NADSYN1(2), PPAT(2), QARS(1) 15140759 50 42 50 23 8 13 13 13 3 0 0.877 1.000 1.000 474 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG2(1), ASS1(1), CKB(3), CKM(2), CKMT1B(1), CPS1(11), EPRS(2), GATM(2), GLUD1(2), GLUD2(4), GOT1(1), GOT2(2), LAP3(1), NOS1(3), NOS3(4), OTC(1), P4HA1(1), P4HA2(1), P4HA3(1), PARS2(3), PRODH(1), PYCR1(1), RARS(1), RARS2(3) 16376141 54 42 54 17 14 9 15 15 1 0 0.435 1.000 1.000 475 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(3), IKBKB(5), IL1A(1), IL1B(1), IL1R1(2), IL1RAP(4), IRAK1(1), IRAK2(2), IRAK3(4), MAP2K3(3), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TGFB1(1), TGFB2(2), TRAF6(1) 13545349 48 42 48 14 9 11 14 6 8 0 0.408 1.000 1.000 476 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), DAG1(1), ITPKA(1), ITPKB(4), ITPR1(8), ITPR2(11), ITPR3(5), NFAT5(5), PDE6A(1), PDE6C(2), SLC6A13(3), TF(3) 16196113 50 42 50 21 5 17 12 9 7 0 0.696 1.000 1.000 477 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM1(1), CALM3(1), CHUK(3), EGR2(2), MAP3K1(3), MYC(3), NFATC1(7), NFATC2(6), NFKB1(2), PLCG1(5), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RELA(1), SYT1(5), VIP(1), VIPR2(3) 12742226 51 42 51 19 12 9 15 11 4 0 0.543 1.000 1.000 478 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(3), ACY1(2), ADC(1), AGMAT(1), ALDH18A1(2), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), AOC2(2), AOC3(5), ARG2(1), ASS1(1), CPS1(11), GATM(2), MAOA(1), MAOB(1), NAGS(2), ODC1(1), OTC(1), SAT1(3), SAT2(1), SMS(2) 13395037 50 41 50 15 11 14 14 6 5 0 0.261 1.000 1.000 479 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(6), APOC1(1), CETP(2), CYP7A1(2), HMGCR(3), LCAT(2), LDLR(3), LIPC(3), LPL(2), LRP1(17), SCARB1(1), SOAT1(3) 12484942 45 41 45 13 5 10 15 9 6 0 0.353 1.000 1.000 480 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 18 ATM(9), BRCA1(9), CHEK2(4), MAPK8(4), MDM2(2), MRE11A(1), NFKB1(2), RAD50(5), RAD51(1), RBBP8(6), RELA(1) 13212544 44 40 44 15 4 13 13 9 5 0 0.708 1.000 1.000 481 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(3), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH3B1(1), ALDH3B2(2), ALDH9A1(2), AOC2(2), AOC3(5), ASPA(1), CNDP1(3), DDC(7), HAL(2), HDC(2), MAOA(1), MAOB(1), PRPS1(3), PRPS2(1) 11101012 45 40 45 13 8 11 14 4 8 0 0.234 1.000 1.000 482 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(1), CHIT1(2), CTBS(1), CYB5R1(1), CYB5R3(2), GFPT1(2), GFPT2(2), GNE(1), GNPDA1(1), GNPNAT1(1), HEXA(3), HK1(3), HK2(5), HK3(4), LHPP(1), MTMR2(5), MTMR6(2), NANS(2), PGM3(1), PHPT1(1), RENBP(3), UAP1(2) 13065355 47 40 47 16 10 11 12 5 9 0 0.549 1.000 1.000 483 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 AACS(1), ABAT(5), ACADS(2), ACAT2(1), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), ECHS1(2), EHHADH(2), GAD1(2), GAD2(2), HADHA(3), HMGCL(1), L2HGDH(4), OXCT1(1), PDHA1(3), PDHA2(5) 11758995 45 39 45 21 7 11 11 6 10 0 0.875 1.000 1.000 484 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(2), ABP1(3), AOC2(2), AOC3(5), CES1(4), CES7(2), DDHD1(2), ESCO1(3), ESCO2(3), LIPA(1), MYST3(4), MYST4(6), PLA1A(5), PRDX6(1), SH3GLB1(2) 11562887 45 39 45 17 4 11 18 7 5 0 0.811 1.000 1.000 485 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 37 ANAPC1(5), ANAPC2(1), ANAPC5(1), ANAPC7(1), BTRC(1), CDC16(1), CDC20(2), CDC23(1), CDC27(3), CUL1(6), CUL2(1), FZR1(2), ITCH(5), RBX1(2), SKP1(1), SKP2(2), SMURF1(2), SMURF2(4), TCEB1(1), UBE2D2(1), UBE2E1(1), WWP1(3), WWP2(2) 16777614 49 39 49 17 6 15 10 12 6 0 0.638 1.000 1.000 486 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 14 ATN1(9), CASP1(2), CASP3(1), CASP7(1), INSR(2), ITCH(5), MAGI1(3), MAGI2(10), RERE(5), WWP1(3), WWP2(2) 10392138 43 39 42 16 5 14 12 7 5 0 0.746 1.000 1.000 487 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(2), GPT2(2), MDH1(1), ME1(2), ME3(6), PGK2(3), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TKTL1(3), TKTL2(7), TPI1(2) 9208910 42 38 42 15 9 7 15 6 5 0 0.614 1.000 1.000 488 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(5), BST1(2), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3), NT5C1A(1), NT5C1B(4), NT5C2(1), NT5C3(2), NUDT12(3) 9826266 41 38 41 19 5 6 18 8 4 0 0.930 1.000 1.000 489 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(5), ADSL(4), ADSS(2), AGXT2(2), ASNS(4), ASPA(1), CAD(2), DARS(2), GAD1(2), GAD2(2), GOT1(1), GOT2(2), GPT2(2), NARS(2), PC(7) 11884905 41 37 41 17 8 10 14 6 3 0 0.660 1.000 1.000 490 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(2), EGF(6), EGFR(14), MET(1), PDGFRA(6), PRKCA(2), SH3GLB1(2), SH3KBP1(6), SRC(1) 8839014 40 37 40 13 4 8 14 8 6 0 0.457 1.000 1.000 491 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ALPI(2), ALPL(3), ALPP(2), ALPPL2(4), CMBL(2), CYP3A4(3), CYP3A43(1), CYP3A5(1), CYP3A7(1), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3) 8202193 44 37 44 19 8 5 15 10 6 0 0.857 1.000 1.000 492 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(2), EXT2(2), EXTL1(2), EXTL2(2), EXTL3(2), HS2ST1(4), HS3ST2(2), HS3ST3B1(1), HS3ST5(6), HS6ST1(2), HS6ST2(1), HS6ST3(1), NDST1(1), NDST2(2), NDST3(4), NDST4(7) 9435294 41 37 41 19 10 7 15 6 3 0 0.836 1.000 1.000 493 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ACOT11(1), ALDH1B1(2), ALDH2(1), ALDH7A1(2), ALDH9A1(2), CYP2C19(3), CYP2C9(5), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1) 14092645 47 37 47 21 3 9 19 10 6 0 0.940 1.000 1.000 494 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 15 AKT1(2), AKT2(3), AKT3(4), BPNT1(1), ILK(4), MAPK1(4), PDK1(1), PIK3CD(2), PTEN(6), PTK2B(2), RBL2(3), SHC1(1), SOS1(7) 8320144 40 37 37 12 6 7 16 6 5 0 0.359 1.000 1.000 495 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(2), DARS(2), EPRS(2), FARS2(2), GARS(1), IARS(7), KARS(2), LARS2(1), MARS(2), MARS2(4), NARS(2), QARS(1), RARS(1), SARS(1), TARS(3), WARS2(5), YARS(3) 14571823 42 36 41 17 5 6 19 10 2 0 0.862 1.000 1.000 496 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ACAA2(1), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH6(1), ADH7(1), ADHFE1(2), AKR1C4(2), AKR1D1(2), ALDH1A2(6), ALDH1B1(2), ALDH2(1), ALDH9A1(2), BAAT(2), CEL(1), CYP27A1(2), CYP7A1(2), HADHB(2), SOAT2(2), SRD5A2(2) 10577856 42 36 42 17 6 10 14 6 6 0 0.749 1.000 1.000 497 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 17 CSF1(1), DDX20(3), E2F4(1), ETS1(2), ETS2(5), FOS(1), HDAC5(1), NCOR2(11), RBL1(8), RBL2(3), SIN3A(2), SIN3B(5) 11664609 43 36 43 16 7 13 13 5 5 0 0.430 1.000 1.000 498 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(1), GLB1(4), GNS(1), GUSB(1), HEXA(3), HGSNAT(2), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(2), IDS(3), IDUA(3), LCT(8), NAGLU(1), SPAM1(2) 9290213 38 36 38 12 7 7 10 10 4 0 0.507 1.000 1.000 499 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(8), AP2A1(2), AP2M1(3), BIN1(1), CALM1(1), CALM3(1), DNM1(1), EPN1(4), EPS15(2), PICALM(3), SYNJ1(6), SYNJ2(5), SYT1(5) 9847906 42 36 42 17 5 6 16 9 6 0 0.888 1.000 1.000 500 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 ALAD(2), BLVRA(2), CP(4), CPOX(1), EPRS(2), FECH(1), GUSB(1), HCCS(2), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8), UROD(1), UROS(3) 12503061 39 36 39 21 4 8 15 11 1 0 0.969 1.000 1.000 501 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CHUK(3), CRADD(1), IKBKB(5), LTA(1), MAP2K3(3), MAP2K4(1), MAP2K6(1), MAP3K1(3), MAP3K14(2), MAP4K2(1), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TRAF2(1) 11015915 36 36 36 11 6 6 13 6 5 0 0.523 1.000 1.000 502 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 GATA3(6), IL13(1), IL4(1), IL5(1), JUNB(1), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(7), NFATC2(6), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 5525405 36 35 36 15 10 8 7 7 4 0 0.467 1.000 1.000 503 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(3), ACAD9(2), ADH1A(2), ADH1B(1), ADH1C(2), ADH4(4), ADH5(2), ADH6(1), ADH7(1), ADHFE1(2), DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2) 11377238 43 35 43 17 4 11 12 10 6 0 0.833 1.000 1.000 504 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 18 ABCB1(11), AKT1(2), ATM(9), BAX(1), CPB2(3), CSNK1A1(1), FHL2(1), HIC1(1), HIF1A(2), IGFBP3(1), MAPK8(4), MDM2(2), NFKBIB(1) 9096261 39 35 39 14 4 7 15 7 6 0 0.823 1.000 1.000 505 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 AANAT(1), ACHE(2), CHAT(6), DBH(4), DDC(7), GAD1(2), GAD2(2), HDC(2), MAOA(1), PAH(4), PNMT(1), SLC18A3(3), TH(2), TPH1(2) 6571771 39 34 39 16 5 9 11 5 9 0 0.656 1.000 1.000 506 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CD80(5), CR1(8), CR2(5), FCGR2B(1), HLA-DRA(1), ICAM1(2), ITGAL(2), ITGB2(2), PTPRC(13) 6927972 39 34 39 22 3 11 8 8 9 0 0.956 1.000 1.000 507 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 12 C1R(3), C1S(3), C3(7), C5(5), C7(5), C8A(6), C8B(4), C9(5), MASP1(4) 8617438 42 34 42 19 1 14 14 7 6 0 0.853 1.000 1.000 508 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 13 C1R(3), C1S(3), C3(7), C5(5), C7(5), C8A(6), C9(5), MASP1(4), MASP2(4), MBL2(2) 8851628 44 34 44 17 1 15 13 9 6 0 0.697 1.000 1.000 509 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(3), POLD2(1), POLE(8), POLG(2), POLL(5), POLQ(16) 7617736 36 34 36 14 6 8 8 5 9 0 0.573 1.000 1.000 510 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(8), EGF(6), EGFR(14), HGS(1), RAB5A(2), TF(3), TFRC(3) 5847123 37 34 37 12 3 10 13 7 4 0 0.587 1.000 1.000 511 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(11), CPT1A(4), LEP(1), LEPR(11), PRKAA1(3), PRKAA2(2), PRKAB1(3), PRKAG2(2) 6592726 37 34 37 17 5 6 13 8 5 0 0.932 1.000 1.000 512 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 17 CABIN1(7), CALM1(1), CALM3(1), CAPN2(4), CAPNS1(1), CAPNS2(2), NFATC1(7), NFATC2(6), PRKCA(2), SYT1(5) 8886084 36 34 36 16 7 6 9 10 4 0 0.747 1.000 1.000 513 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(3), FADD(1), IKBKB(5), IL1A(1), IL1R1(2), IRAK1(1), MAP3K1(3), MAP3K14(2), MAP3K7(4), NFKB1(2), RELA(1), RIPK1(2), TLR4(7), TNFAIP3(3), TRAF6(1) 11126084 38 34 38 16 7 8 14 6 3 0 0.760 1.000 1.000 514 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 11 CREBBP(15), PAX3(4), PML(1), RARA(2), RB1(10), SIRT1(1), SP100(1) 8083600 34 34 34 16 1 6 12 3 12 0 0.961 1.000 1.000 515 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 12 CARM1(3), CREB1(1), CREBBP(15), NCOA3(4), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RARA(2), RXRA(4) 7156486 37 33 37 13 7 10 11 4 5 0 0.616 1.000 1.000 516 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(7), ACO2(2), CS(2), DLST(4), FH(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(7), SDHA(4), SUCLA2(1), SUCLG2(3) 9387222 37 33 37 12 5 9 12 8 3 0 0.383 1.000 1.000 517 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 14 C3(7), C5(5), C7(5), ICAM1(2), IL1A(1), ITGA4(6), ITGAL(2), ITGB2(2), SELP(11), VCAM1(3) 9649479 44 33 44 23 2 10 17 9 6 0 0.948 1.000 1.000 518 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(4), ACPP(1), ACPT(1), ENPP1(5), ENPP3(5), FLAD1(4), LHPP(1), MTMR2(5), MTMR6(2), PHPT1(1), TYR(4) 6851614 37 32 37 12 7 4 16 3 7 0 0.752 1.000 1.000 519 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(5), POLR1B(3), POLR1C(2), POLR2A(9), POLR2B(3), POLR2D(1), POLR2G(2), POLR2H(1), POLR2L(1), POLR3A(8), POLR3B(2), POLR3G(1), POLR3H(1) 10695384 39 32 39 12 5 10 11 4 9 0 0.445 1.000 1.000 520 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC2(4), ABCG2(2), BCHE(5), CES1(4), CES2(7), CYP3A4(3), CYP3A5(1), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2) 10406050 36 32 36 23 6 6 15 5 4 0 0.983 1.000 1.000 521 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADL(2), ACADM(3), ACADS(2), ACADVL(4), ACSL1(2), ACSL3(1), ACSL4(6), CPT1A(4), CPT2(2), DCI(1), EHHADH(2), HADHA(3), SLC25A20(1) 7655447 33 32 33 11 4 7 9 8 5 0 0.574 1.000 1.000 522 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(12), GNAS(6), PLCE1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), RAP2B(1) 6702553 39 32 39 12 10 7 15 4 3 0 0.423 1.000 1.000 523 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(2), GRM1(16), PLCB1(12), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2) 7259989 39 31 39 15 6 10 15 8 0 0 0.528 1.000 1.000 524 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(8), GABRA2(7), GABRA3(4), GABRA4(3), GABRA5(5), GABRA6(2), GPHN(1), NSF(1), SRC(1), UBQLN1(2) 5449046 35 31 35 14 2 8 14 4 7 0 0.809 1.000 1.000 525 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(1), GALC(2), GBA(2), GLA(3), GLB1(4), LCT(8), NEU1(1), NEU2(1), PPAP2B(1), SMPD1(1), SMPD2(1), SPTLC1(1), SPTLC2(2), UGCG(1) 10965422 33 31 33 15 5 9 8 5 6 0 0.770 1.000 1.000 526 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 ACAT2(1), ACOT11(1), ACYP1(1), DHRS1(1), DHRS2(3), DHRS7(1), ECHS1(2), EHHADH(2), ESCO1(3), ESCO2(3), FN3K(2), GCDH(1), HADHA(3), MYST3(4), MYST4(6), SH3GLB1(2), YOD1(1) 11846896 37 31 37 16 2 7 12 11 5 0 0.904 1.000 1.000 527 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 14 CHUK(3), CREBBP(15), FADD(1), HDAC3(1), IKBKB(5), NFKB1(2), RELA(1), RIPK1(2), TRAF6(1) 7970800 31 31 31 12 3 8 12 5 3 0 0.704 1.000 1.000 528 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNG(1), IFNGR1(4), IFNGR2(2), IKBKB(5), JAK2(2), LIN7A(2), NFKB1(2), RB1(10), RELA(1), USH1C(2) 7912106 32 31 31 15 2 6 9 3 12 0 0.862 1.000 1.000 529 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 CD2(1), CD33(2), CD7(2), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL3(1), IL4(1), IL5(1), ITGAX(5), TLR2(1), TLR4(7), TLR7(4), TLR9(2) 8478474 34 30 34 16 5 5 12 8 4 0 0.842 1.000 1.000 530 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 CPB2(3), F2(2), FGA(7), FGB(2), FGG(3), PLAT(2), PLAU(1), PLG(8), SERPINB2(2), SERPINE1(4) 6104274 34 30 34 11 4 6 12 4 8 0 0.569 1.000 1.000 531 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(11), ACACB(12), FASN(4), MCAT(2), OLAH(2), OXSM(2) 7231847 33 30 33 13 7 8 10 6 2 0 0.615 1.000 1.000 532 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT2(1), COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), ILVBL(3), PANK2(1), PANK4(1), PPCS(2), UPB1(1), VNN1(2) 7897888 35 30 35 17 4 5 16 7 3 0 0.955 1.000 1.000 533 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(3), DYRK1B(6), GLI2(8), GLI3(5), GSK3B(1), PRKACB(2), PRKACG(1), PRKAR1A(2), PRKAR1B(1), PRKAR2B(2), SMO(1), SUFU(1) 7572285 33 30 33 13 5 8 11 6 3 0 0.678 1.000 1.000 534 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 20 BAD(1), BAX(1), BCL2(1), FADD(1), MAP2K1(4), MAP2K4(1), MAP3K1(3), MAPK1(4), MAPK8(4), NFKB1(2), NSMAF(3), RAF1(2), RELA(1), RIPK1(2), SMPD1(1), TRAF2(1) 8841555 32 29 29 10 10 3 12 3 4 0 0.533 1.000 1.000 535 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(6), ATIC(2), DHFR(3), FTCD(1), GART(3), MTFMT(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1) 8616231 35 29 35 14 4 6 17 4 4 0 0.788 1.000 1.000 536 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR1(3), ESR2(1), ITPKA(1), PDE1A(3), PDE1B(2), PLCB1(12), PLCB2(4), PRL(3), TRH(2), VIP(1) 5059206 32 29 32 14 4 3 17 5 3 0 0.812 1.000 1.000 537 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 12 AKT1(2), BAD(1), CHRNG(4), MUSK(6), PIK3R1(6), PTK2(5), PTK2B(2), SRC(1), TERT(1), YWHAH(1) 6472934 29 28 29 12 3 6 7 7 6 0 0.696 1.000 1.000 538 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(1), ALDOB(3), ALDOC(1), FBP2(1), GOT1(1), GOT2(2), GPT2(2), MDH1(1), ME1(2), ME2(1), ME3(6), PKLR(1), PKM2(3), RPE(1), RPIA(1), TKT(1), TPI1(2) 8239345 30 28 30 11 8 5 11 4 2 0 0.606 1.000 1.000 539 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 10 C1R(3), C1S(3), C3(7), C5(5), C7(5), C8A(6), C9(5) 7115627 34 28 34 16 1 13 12 5 3 0 0.853 1.000 1.000 540 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 BECN1(1), IFNA16(2), IFNA17(1), IFNA21(1), IFNA4(2), IFNA6(1), IFNA8(2), IFNG(1), PIK3C3(2), PIK3R4(7), PRKAA1(3), PRKAA2(2), ULK1(5), ULK2(2) 9628879 32 28 32 19 5 4 14 8 1 0 0.985 1.000 1.000 541 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL10RA(3), IL22(1), IL22RA1(2), JAK1(6), JAK2(2), JAK3(3), STAT1(5), STAT3(3), STAT5A(1), STAT5B(4), TYK2(2) 8357068 32 28 31 14 2 11 9 5 5 0 0.665 1.000 1.000 542 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 10 CD44(1), ICAM1(2), ITGA4(6), ITGAL(2), ITGAM(3), ITGB2(2), SELE(4), SELL(2), SELP(11) 6467596 33 28 33 17 2 5 11 8 7 0 0.941 1.000 1.000 543 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(11), ABCB11(6), ABCB4(9), ABCC3(3) 6520323 29 28 29 15 3 8 11 2 5 0 0.837 1.000 1.000 544 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(2), GALNT10(2), GALNT2(3), GALNT3(3), GALNT4(2), GALNT6(3), GALNT8(5), GCNT1(1), ST3GAL1(1), ST3GAL4(1), WBSCR17(8) 6580765 31 28 31 14 5 7 10 2 7 0 0.800 1.000 1.000 545 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(1), RPE(1), UCHL3(1), UGDH(3), UGT1A1(1), UGT1A10(2), UGT1A5(2), UGT1A6(1), UGT1A7(2), UGT1A8(2), UGT2B15(2), UGT2B4(8) 8010556 28 28 28 15 6 3 8 10 1 0 0.932 1.000 1.000 546 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM1(1), CALM3(1), CAMK1(1), CAMK1G(1), CAMK2A(2), CAMK2B(2), CAMK2D(1), CAMK2G(1), ESRRA(4), HDAC5(1), MEF2A(1), MEF2B(2), MEF2C(7), SLC2A4(1), SYT1(5), YWHAH(1) 9228378 32 28 31 10 2 9 12 7 2 0 0.426 1.000 1.000 547 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 6 CREBBP(15), LPL(2), NCOA1(4), NCOA2(3), RXRA(4) 6174443 28 28 28 11 3 4 12 6 3 0 0.824 1.000 1.000 548 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), CYSLTR2(2), GPR109B(4), GPR161(3), GPR171(2), GPR18(1), GPR34(1), GPR39(4), GPR45(3), GPR68(1), GPR75(4), GPR81(2) 4478212 28 27 28 13 8 6 6 6 2 0 0.697 1.000 1.000 549 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 36 G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GPX6(1), GPX7(1), GSS(2), GSTA1(2), GSTA3(2), GSTA5(2), GSTK1(1), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), OPLAH(2) 10041415 29 27 29 15 4 9 8 6 2 0 0.816 1.000 1.000 550 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(6), ATIC(2), DHFR(3), GART(3), MTHFD1(2), MTHFD1L(3), MTHFD2(1), MTHFR(1), MTHFS(2), MTR(4), SHMT1(1), SHMT2(2), TYMS(1) 8139038 31 27 31 14 4 5 15 4 3 0 0.870 1.000 1.000 551 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 13 AKT1(2), AKT2(3), AKT3(4), ELK1(1), MAP2K1(4), MAP2K2(3), NGFR(1), NTRK1(3), PIK3CD(2), SHC1(1), SOS1(7) 6162139 31 27 31 11 6 6 11 7 1 0 0.547 1.000 1.000 552 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(3), IKBKB(5), LTA(1), MAP3K1(3), MAP3K14(2), NFKB1(2), RELA(1), RIPK1(2), TANK(2), TNFAIP3(3), TRAF2(1), TRAF3(3) 10244486 28 27 28 10 4 5 7 6 6 0 0.591 1.000 1.000 553 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(3), IFNG(1), IKBKB(5), IL4(1), MAP3K1(3), MAP3K5(5), MAPK14(1), MAPK8(4), NFKB1(2), RELA(1), TNFRSF9(1), TRAF2(1) 8870258 29 26 29 13 4 5 11 5 4 0 0.867 1.000 1.000 554 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT2(1), IARS(7), ILVBL(3), LARS2(1), PDHA1(3), PDHA2(5), VARS(5), VARS2(1) 8506475 26 26 26 16 0 7 11 5 3 0 0.981 1.000 1.000 555 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(2), CAT(2), EPX(5), MPO(5), MTHFR(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10) 5297708 29 26 28 14 11 3 12 2 1 0 0.807 1.000 1.000 556 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(4), CRY1(3), CRY2(1), CSNK1E(3), NPAS2(1), NR1D1(1), PER1(5), PER2(2), PER3(8) 7772119 29 26 29 11 6 6 9 6 2 0 0.624 1.000 1.000 557 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(2), CAT(2), EPX(5), MPO(5), PRDX2(1), PRDX6(1), SHMT1(1), SHMT2(2), TPO(10) 5381448 29 26 28 14 10 3 12 3 1 0 0.807 1.000 1.000 558 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 COASY(1), DPYD(8), DPYS(5), ENPP1(5), ENPP3(5), PANK2(1), PANK4(1), PPCS(2), UPB1(1) 6363188 29 26 29 13 4 4 13 6 2 0 0.914 1.000 1.000 559 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 26 BAG4(4), BIRC2(1), BIRC3(1), CASP3(1), CFLAR(2), FADD(1), MAP2K4(1), MAP3K3(1), MAP3K7(4), NFKB1(2), NFKB2(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(2), RIPK1(2), TNFAIP3(3), TRAF2(1) 11922181 30 26 30 13 6 10 9 1 4 0 0.663 1.000 1.000 560 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(5), GBA3(5), MPO(5), PRDX2(1), PRDX6(1), TPO(10), TYR(4) 4402726 31 26 30 15 7 2 16 4 2 0 0.879 1.000 1.000 561 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 AHCY(1), CTH(2), DNMT1(4), DNMT3A(8), DNMT3B(5), MARS(2), MARS2(4), MAT1A(1), MTR(4) 7926355 31 25 30 10 6 7 12 5 1 0 0.383 1.000 1.000 562 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(5), CD38(2), ENPP1(5), ENPP3(5), NADSYN1(2), NMNAT1(3), NMNAT2(2), NNMT(1), NNT(3) 6643280 28 25 28 12 2 5 14 4 3 0 0.881 1.000 1.000 563 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 17 ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), NCK1(4), NCKAP1(5), NTRK1(3), PIR(1), WASF1(3), WASF2(2), WASF3(2), WASL(1) 6752678 28 24 28 14 6 8 6 7 1 0 0.887 1.000 1.000 564 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2B1(2), MAN2B2(1), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1) 9258084 25 24 25 13 7 4 5 5 4 0 0.827 1.000 1.000 565 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 MRPS7(1), RPL10L(4), RPL12(1), RPL13A(1), RPL18(2), RPL26(1), RPL28(1), RPL31(1), RPL37(1), RPL37A(1), RPL3L(1), RPL6(2), RPS10(1), RPS13(2), RPS20(1), RPS21(1), RPS23(1), RPS28(1), RPS3(1), RPS5(1) 10315877 26 24 25 10 4 6 11 1 4 0 0.829 1.000 1.000 566 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT2(3), B4GALT5(2), DPAGT1(1), DPM1(2), FUT8(2), MAN1B1(3), MGAT1(1), MGAT2(1), MGAT3(4), MGAT4B(3), MGAT5(1), RPN1(1), RPN2(2) 9135403 28 24 28 10 5 4 6 7 6 0 0.586 1.000 1.000 567 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD2(1), CD3D(1), CXCR3(1), IFNG(1), IL12A(1), IL12B(4), IL12RB1(3), IL12RB2(7), JAK2(2), STAT4(3), TYK2(2) 6687738 26 24 26 10 1 7 8 5 5 0 0.656 1.000 1.000 568 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), CD8A(2), ICAM1(2), ITGAL(2), ITGB2(2), PTPRC(13), THY1(1) 4902911 26 24 26 16 3 3 4 7 9 0 0.940 1.000 1.000 569 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 5 C3(7), C5(5), C7(5), C8A(6), C9(5) 4858899 28 23 28 12 1 9 11 5 2 0 0.832 1.000 1.000 570 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(5), GBA(2), GBA3(5), MPO(5), PRDX6(1), TPO(10) 3820579 28 23 27 13 7 4 13 3 1 0 0.773 1.000 1.000 571 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 6 CREBBP(15), ESR1(3), MAPK1(4), PELP1(1), SRC(1) 4457931 24 23 21 10 3 4 9 4 4 0 0.772 1.000 1.000 572 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(2), ATP6V0B(1), ATP6V0D1(1), ATP6V1A(1), ATP6V1B1(2), ATP6V1B2(2), ATP6V1C1(3), ATP6V1C2(3), ATP6V1D(1), ATP6V1E1(1), ATP6V1G2(1), ATP6V1G3(1), ATP6V1H(2), FDXR(3), SHMT1(1) 7291311 26 23 26 10 5 5 9 3 4 0 0.725 1.000 1.000 573 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 C9orf47(2), CNR1(3), DNMT1(4), MTNR1A(2), MTNR1B(2), PTGDR(1), PTGER2(4), PTGER4(2), PTGFR(2), TBXA2R(1) 5099081 23 23 23 12 5 4 11 2 1 0 0.693 1.000 1.000 574 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 30 G6PD(2), GCLM(1), GGT1(1), GPX2(2), GPX4(2), GSS(2), GSTA1(2), GSTA3(2), GSTM2(2), GSTM4(1), GSTT1(1), IDH1(2), MGST1(1), MGST3(1), PGD(2) 8229452 24 22 24 10 5 7 4 5 3 0 0.623 1.000 1.000 575 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(3), PGAP1(3), PIGA(1), PIGB(2), PIGC(1), PIGG(1), PIGK(5), PIGN(2), PIGO(2), PIGS(1), PIGT(1), PIGZ(1) 10844023 24 22 24 22 4 4 7 4 5 0 0.999 1.000 1.000 576 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(1), ESR1(3), GREB1(11), MTA1(4), MTA3(3), PDZK1(2), TUBA8(2) 4996950 26 22 26 12 7 0 10 6 3 0 0.820 1.000 1.000 577 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 7 IFNAR1(2), JAK1(6), PTPRU(6), STAT1(5), STAT2(3), TYK2(2) 5537181 24 22 24 10 4 7 5 2 6 0 0.639 1.000 1.000 578 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD2(1), CD28(2), CD3D(1), ICAM1(2), ITGAL(2), ITGB2(2), PTPRC(13), THY1(1) 5143284 24 22 24 17 2 3 4 7 8 0 0.975 1.000 1.000 579 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT1(1), B3GNT2(1), B3GNT7(1), B4GALT2(3), CHST1(3), CHST2(2), CHST4(3), CHST6(6), FUT8(2), ST3GAL1(1), ST3GAL3(1), ST3GAL4(1) 5735233 25 21 25 14 10 3 8 1 3 0 0.891 1.000 1.000 580 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 FUCA1(1), GLB1(4), HEXA(3), LCT(8), MAN2C1(2), MANBA(2), NEU1(1), NEU2(1) 7511162 22 21 22 10 6 3 5 5 3 0 0.757 1.000 1.000 581 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(5), CD44(1), CSF1(1), FCGR3A(4), IL1B(1), IL6R(4), SELL(2), SPN(2), TGFB1(1), TGFB2(2), TNFSF8(2) 6006613 25 21 25 11 6 6 6 5 2 0 0.593 1.000 1.000 582 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2) 4183404 20 20 20 11 4 4 8 2 2 0 0.865 1.000 1.000 583 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 AKR1C4(2), AKR1D1(2), CYP11A1(2), CYP11B1(4), CYP11B2(3), CYP21A2(2), HSD11B2(1), HSD3B1(2), HSD3B2(2) 4183404 20 20 20 11 4 4 8 2 2 0 0.865 1.000 1.000 584 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS1(1), DHRS2(3), DHRS7(1), ESCO1(3), ESCO2(3), MYST3(4), MYST4(6), SH3GLB1(2) 7553221 23 20 23 14 1 4 10 5 3 0 0.992 1.000 1.000 585 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 7 ACE(5), AGT(2), AGTR2(2), KNG1(3), NOS3(4), REN(3) 4170177 19 19 19 12 5 4 6 1 3 0 0.887 1.000 1.000 586 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(3), DHRS1(1), DHRS2(3), DHRS7(1), PON1(6), PON2(1), PON3(3), RDH11(1), RDH12(3) 4102728 22 19 22 12 1 3 8 9 1 0 0.934 1.000 1.000 587 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 CYP27B1(1), DHCR7(1), FDFT1(3), FDPS(2), GGCX(3), HMGCR(3), IDI1(1), LSS(3), PMVK(1), SC4MOL(1), TM7SF2(1) 8797914 20 18 20 12 6 5 4 1 4 0 0.919 1.000 1.000 588 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNAR1(2), IFNAR2(1), JAK1(6), STAT1(5), STAT2(3), TYK2(2) 4935436 19 18 19 11 2 6 4 2 5 0 0.907 1.000 1.000 589 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ICAM1(2), ITGA4(6), ITGAL(2), ITGB2(2), SELE(4), SELL(2) 4737430 19 18 19 15 2 3 4 5 5 0 0.990 1.000 1.000 590 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(2), CHAT(6), PCYT1A(1), PDHA1(3), PDHA2(5), SLC18A3(3) 3189313 20 17 20 14 2 4 7 4 3 0 0.976 1.000 1.000 591 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(2), PLCB1(12), PRKCA(2), RELA(1) 3759828 17 17 17 7 3 3 8 3 0 0 0.733 1.000 1.000 592 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAD(2), ALAS2(4), CPO(2), FECH(1), GATA1(1), HBA2(2), UROD(1), UROS(3) 3556541 16 16 16 7 2 3 7 4 0 0 0.760 1.000 1.000 593 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ICAM1(2), ITGAL(2), ITGAM(3), ITGB2(2), SELE(4), SELL(2) 4720160 16 16 16 15 1 2 4 4 5 0 0.996 1.000 1.000 594 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 IARS(7), LARS2(1), PDHA1(3), PDHA2(5) 4561919 16 16 16 12 0 4 7 4 1 0 0.996 1.000 1.000 595 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(1), FDFT1(3), FDPS(2), HMGCR(3), HMGCS1(2), IDI1(1), LSS(3), PMVK(1), SC4MOL(1) 6015011 17 15 17 10 5 5 2 3 2 0 0.897 1.000 1.000 596 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CSF1(1), HLA-DRA(1), IFNG(1), IL12A(1), IL12B(4), IL13(1), IL1A(1), IL3(1), IL4(1), IL5(1), LTA(1), TGFB1(1), TGFB2(2) 6055633 17 15 17 12 4 4 2 5 2 0 0.960 1.000 1.000 597 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 CPS1(11), GLS(1), GLUD1(2), GOT1(1) 3554471 15 15 15 5 3 3 3 6 0 0 0.596 1.000 1.000 598 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSS(2), NFKB1(2), NOX1(5), RELA(1), XDH(3) 4517257 13 13 13 10 2 3 3 3 2 0 0.959 1.000 1.000 599 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAD(2), ALAS2(4), CPOX(1), FECH(1), UROD(1), UROS(3) 3442046 12 12 12 6 1 3 4 4 0 0 0.835 1.000 1.000 600 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 ASRGL1(1), GBA(2), GBA3(5), GGT1(1), SHMT1(1), SHMT2(2) 2504290 12 12 12 5 3 2 4 3 0 0 0.767 1.000 1.000 601 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 11 ACTA1(2), ACTR2(1), ARPC1B(1), ARPC2(2), ARPC4(1), CDC42(1), WASF1(3), WASL(1) 3503238 12 12 12 9 3 5 1 3 0 0 0.954 1.000 1.000 602 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 8 CD3D(1), GZMB(1), ICAM1(2), ITGAL(2), ITGB2(2), PRF1(3) 3543058 11 11 11 10 3 1 2 2 3 0 0.961 1.000 1.000 603 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CPN2(2), CYP11A1(2), CYP11B2(3), HSD11B2(1), HSD3B1(2), HSD3B2(2) 3147790 12 11 12 11 2 1 6 1 2 0 0.978 1.000 1.000 604 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 8 MMP14(2), MMP2(2), RECK(6), TIMP1(1) 3219935 11 11 11 10 0 5 3 3 0 0 0.970 1.000 1.000 605 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(2), CSF1(1), IL1B(1), MST1(2), MST1R(5) 2968399 11 10 11 6 3 3 5 0 0 0 0.781 1.000 1.000 606 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(5), GGT1(1), SHMT1(1), SHMT2(2) 1887272 9 9 9 5 2 0 4 3 0 0 0.927 1.000 1.000 607 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(1), GLS2(1), GLUD1(2), GLUD2(4) 2078035 8 8 8 4 2 2 2 2 0 0 0.859 1.000 1.000 608 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 9 BAG4(4), BIRC3(1), FADD(1), RIPK1(2), TRAF2(1) 3296555 9 8 9 5 2 3 4 0 0 0 0.768 1.000 1.000 609 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(2), APOBEC1(1), APOBEC2(1), APOBEC3B(3) 3342125 7 7 7 6 1 1 2 3 0 0 0.974 1.000 1.000 610 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 CCR3(3), HLA-DRA(1), IL3(1), IL5(1) 1379968 6 6 6 4 1 3 2 0 0 0 0.856 1.000 1.000 611 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 5 BCL2(1), CASP3(1), CFL1(2), CFLAR(2) 1233220 6 6 6 4 2 4 0 0 0 0 0.723 1.000 1.000 612 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), GLS(1), GLUD1(2), PRODH(1) 2521890 5 5 5 3 1 1 0 3 0 0 0.843 1.000 1.000 613 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(3), SUCLA2(1) 959652 4 4 4 3 0 0 4 0 0 0 0.925 1.000 1.000 614 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 HLCS(1), SPCS3(1) 1392715 2 2 2 2 0 1 1 0 0 0 0.894 1.000 1.000 615 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(2) 779493 2 2 2 3 0 1 1 0 0 0 0.962 1.000 1.000 616 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 328481 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000