Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.271 0.229 -9999.0 0.0 -0.864 14.0 14.0 IHH -0.054 0.075 -9999.0 0.0 -0.775 3.0 3.0 SHH Np/Cholesterol/GAS1 -0.038 0.143 -9999.0 0.0 -0.501 41.0 41.0 LRPAP1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.044 0.139 0.497 41.0 -9999.0 0.0 41.0 SMO/beta Arrestin2 -0.14 0.151 -9999.0 0.0 -0.575 22.0 22.0 SMO -0.155 0.159 -9999.0 0.0 -0.607 23.0 23.0 AKT1 -0.061 0.092 -9999.0 0.0 -0.719 3.0 3.0 ARRB2 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.039 0.168 -9999.0 0.0 -0.572 45.0 45.0 ADRBK1 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.153 0.157 -9999.0 0.0 -0.596 23.0 23.0 STIL -0.132 0.164 -9999.0 0.0 -0.605 32.0 32.0 DHH N/PTCH2 -0.014 0.086 -9999.0 0.0 -0.526 13.0 13.0 DHH N/PTCH1 -0.134 0.136 -9999.0 0.0 -0.695 8.0 8.0 PIK3CA 0.014 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.009 0.053 -9999.0 0.0 -0.819 2.0 2.0 PTHLH -0.45 0.335 -9999.0 0.0 -0.658 351.0 351.0 determination of left/right symmetry -0.153 0.157 -9999.0 0.0 -0.596 23.0 23.0 PIK3R1 0.01 0.045 -9999.0 0.0 -0.566 3.0 3.0 skeletal system development -0.446 0.332 -9999.0 0.0 -0.652 351.0 351.0 IHH N/Hhip -0.055 0.168 -9999.0 0.0 -0.672 33.0 33.0 DHH N/Hhip -0.04 0.152 -9999.0 0.0 -0.615 32.0 32.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.153 0.157 -9999.0 0.0 -0.596 23.0 23.0 pancreas development -0.038 0.194 -9999.0 0.0 -0.801 30.0 30.0 HHAT 0.011 0.037 -9999.0 0.0 -0.566 2.0 2.0 PI3K -0.002 0.031 -9999.0 0.0 -0.406 3.0 3.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.004 0.087 -9999.0 0.0 -0.711 7.0 7.0 somite specification -0.153 0.157 -9999.0 0.0 -0.596 23.0 23.0 SHH Np/Cholesterol/PTCH1 -0.146 0.171 -9999.0 0.0 -0.58 45.0 45.0 SHH Np/Cholesterol/PTCH2 -0.041 0.155 -9999.0 0.0 -0.537 39.0 39.0 SHH Np/Cholesterol/Megalin -0.06 0.188 -9999.0 0.0 -0.562 56.0 56.0 SHH -0.031 0.172 -9999.0 0.0 -0.619 39.0 39.0 catabolic process -0.159 0.149 -9999.0 0.0 -0.652 10.0 10.0 SMO/Vitamin D3 -0.153 0.174 -9999.0 0.0 -0.625 33.0 33.0 SHH Np/Cholesterol/Hhip -0.063 0.192 -9999.0 0.0 -0.568 57.0 57.0 LRP2 -0.032 0.185 -9999.0 0.0 -0.819 26.0 26.0 receptor-mediated endocytosis -0.171 0.168 -9999.0 0.0 -0.648 37.0 37.0 SHH Np/Cholesterol/BOC -0.061 0.158 -9999.0 0.0 -0.508 38.0 38.0 SHH Np/Cholesterol/CDO -0.039 0.143 -9999.0 0.0 -0.504 38.0 38.0 mesenchymal cell differentiation 0.067 0.189 0.562 57.0 -9999.0 0.0 57.0 mol:Vitamin D3 -0.145 0.171 -9999.0 0.0 -0.578 45.0 45.0 IHH N/PTCH2 -0.024 0.097 -9999.0 0.0 -0.568 14.0 14.0 CDON -0.0 0.089 -9999.0 0.0 -0.566 12.0 12.0 IHH N/PTCH1 -0.16 0.15 -9999.0 0.0 -0.657 10.0 10.0 Megalin/LRPAP1 -0.033 0.14 -9999.0 0.0 -0.628 26.0 26.0 PTCH2 -0.002 0.104 -9999.0 0.0 -0.681 11.0 11.0 SHH Np/Cholesterol -0.036 0.136 -9999.0 0.0 -0.5 39.0 39.0 PTCH1 -0.159 0.15 -9999.0 0.0 -0.655 10.0 10.0 HHIP -0.038 0.194 -9999.0 0.0 -0.802 30.0 30.0