E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.001 0.08 -9999.0 0.0 -0.334 16.0 16.0 KLHL20 0.026 0.068 0.186 8.0 -0.251 7.0 15.0 CYFIP2 0.024 0.029 -9999.0 0.0 -0.424 2.0 2.0 Rac1/GDP 0.025 0.075 0.327 5.0 -0.3 1.0 6.0 ENAH -0.005 0.101 -9999.0 0.0 -0.358 18.0 18.0 AP1M1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP 0.021 0.034 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.03 -9999.0 0.0 -0.172 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin 0.056 0.041 -9999.0 0.0 -0.246 5.0 5.0 RAPGEF1 0.002 0.093 0.29 2.0 -0.378 5.0 7.0 CTNND1 0.027 0.003 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion 0.0 0.103 -9999.0 0.0 -0.345 23.0 23.0 CRK 0.007 0.091 -9999.0 0.0 -0.378 7.0 7.0 E-cadherin/gamma catenin/alpha catenin 0.046 0.047 -9999.0 0.0 -0.371 5.0 5.0 alphaE/beta7 Integrin 0.037 0.025 -9999.0 0.0 -0.324 2.0 2.0 IQGAP1 0.027 0.004 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.048 0.016 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 0.002 0.077 -9999.0 0.0 -0.347 11.0 11.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 0.002 0.018 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 0.044 0.036 -9999.0 0.0 -0.242 6.0 6.0 PI3K 0.006 0.024 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin 0.034 0.05 -9999.0 0.0 -0.429 5.0 5.0 TIAM1 0.021 0.053 -9999.0 0.0 -0.453 6.0 6.0 E-cadherin(dimer)/Ca2+ 0.052 0.036 -9999.0 0.0 -0.23 4.0 4.0 AKT1 0.012 0.029 0.145 1.0 -9999.0 0.0 1.0 PIK3R1 0.023 0.038 -9999.0 0.0 -0.453 3.0 3.0 CDH1 0.021 0.048 -9999.0 0.0 -0.453 5.0 5.0 RhoA/GDP 0.033 0.071 0.33 6.0 -9999.0 0.0 6.0 actin cytoskeleton organization 0.023 0.053 0.144 17.0 -0.186 6.0 23.0 CDC42/GDP 0.029 0.078 0.33 6.0 -9999.0 0.0 6.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin 0.017 0.034 -9999.0 0.0 -0.334 4.0 4.0 ITGB7 0.025 0.031 -9999.0 0.0 -0.453 2.0 2.0 RAC1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin 0.057 0.038 -9999.0 0.0 -0.245 4.0 4.0 E-cadherin/Ca2+/beta catenin/alpha catenin 0.039 0.032 -9999.0 0.0 -0.225 5.0 5.0 mol:GDP 0.015 0.083 0.341 6.0 -0.333 1.0 7.0 CDC42/GTP/IQGAP1 0.035 0.008 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.025 0.031 -9999.0 0.0 -0.453 2.0 2.0 p120 catenin/RhoA/GDP 0.035 0.073 0.34 4.0 -9999.0 0.0 4.0 RAC1/GTP/IQGAP1 0.034 0.01 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.039 0.008 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.024 0.009 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.011 0.036 0.12 4.0 -0.173 6.0 10.0 NME1 0.026 0.019 -9999.0 0.0 -0.396 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.003 0.096 -9999.0 0.0 -0.348 17.0 17.0 regulation of cell-cell adhesion 0.013 0.028 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 0.014 0.027 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP 0.03 0.048 0.24 1.0 -9999.0 0.0 1.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin 0.068 0.049 -9999.0 0.0 -0.453 2.0 2.0 CCND1 0.013 0.043 0.144 3.0 -0.213 6.0 9.0 VAV2 0.005 0.109 -9999.0 0.0 -0.535 4.0 4.0 RAP1/GDP 0.037 0.065 0.325 5.0 -9999.0 0.0 5.0 adherens junction assembly -0.002 0.094 -9999.0 0.0 -0.33 21.0 21.0 homophilic cell adhesion 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.027 0.005 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion 0.05 0.046 -9999.0 0.0 -0.428 2.0 2.0 E-cadherin/beta catenin 0.009 0.035 -9999.0 0.0 -0.33 5.0 5.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.004 0.097 -9999.0 0.0 -0.339 22.0 22.0 PIK3CA 0.019 0.013 -9999.0 0.0 -9999.0 0.0 0.0 Rac1/GTP -0.02 0.071 -9999.0 0.0 -0.386 10.0 10.0 E-cadherin/beta catenin/alpha catenin 0.044 0.037 -9999.0 0.0 -0.265 5.0 5.0 ITGAE 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.003 0.104 -9999.0 0.0 -0.352 23.0 23.0