Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.157 0.141 -9999.0 0.0 -0.576 12.0 12.0 IHH -0.04 0.059 -9999.0 0.0 -0.376 3.0 3.0 SHH Np/Cholesterol/GAS1 0.002 0.069 -9999.0 0.0 -0.215 44.0 44.0 LRPAP1 0.026 0.007 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning -0.002 0.068 0.213 44.0 -9999.0 0.0 44.0 SMO/beta Arrestin2 -0.085 0.12 -9999.0 0.0 -0.466 20.0 20.0 SMO -0.091 0.122 -9999.0 0.0 -0.475 24.0 24.0 AKT1 -0.039 0.105 -9999.0 0.0 -0.508 14.0 14.0 ARRB2 0.026 0.006 -9999.0 0.0 -9999.0 0.0 0.0 BOC -0.017 0.133 -9999.0 0.0 -0.452 42.0 42.0 ADRBK1 0.025 0.008 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.09 0.12 -9999.0 0.0 -0.468 24.0 24.0 STIL -0.086 0.098 -9999.0 0.0 -0.406 12.0 12.0 DHH N/PTCH2 0.03 0.055 -9999.0 0.0 -0.3 13.0 13.0 DHH N/PTCH1 -0.085 0.099 -9999.0 0.0 -0.507 7.0 7.0 PIK3CA 0.019 0.013 -9999.0 0.0 -9999.0 0.0 0.0 DHH 0.021 0.03 -9999.0 0.0 -0.396 2.0 2.0 PTHLH -0.219 0.178 -9999.0 0.0 -0.598 25.0 25.0 determination of left/right symmetry -0.09 0.12 -9999.0 0.0 -0.468 24.0 24.0 PIK3R1 0.023 0.038 -9999.0 0.0 -0.453 3.0 3.0 skeletal system development -0.217 0.177 -9999.0 0.0 -0.592 25.0 25.0 IHH N/Hhip -0.033 0.085 -9999.0 0.0 -0.321 32.0 32.0 DHH N/Hhip 0.017 0.078 -9999.0 0.0 -0.283 31.0 31.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.09 0.12 -9999.0 0.0 -0.468 24.0 24.0 pancreas development -0.007 0.1 -9999.0 0.0 -0.4 29.0 29.0 HHAT 0.025 0.031 -9999.0 0.0 -0.453 2.0 2.0 PI3K 0.026 0.029 -9999.0 0.0 -0.324 2.0 2.0 EntrezGene:84976 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 0.021 0.049 -9999.0 0.0 -0.415 6.0 6.0 somite specification -0.09 0.12 -9999.0 0.0 -0.468 24.0 24.0 SHH Np/Cholesterol/PTCH1 -0.092 0.098 -9999.0 0.0 -0.344 32.0 32.0 SHH Np/Cholesterol/PTCH2 -0.0 0.076 -9999.0 0.0 -0.229 47.0 47.0 SHH Np/Cholesterol/Megalin -0.01 0.085 -9999.0 0.0 -0.238 55.0 55.0 SHH -0.02 0.078 -9999.0 0.0 -0.282 39.0 39.0 catabolic process -0.1 0.104 -9999.0 0.0 -0.518 8.0 8.0 SMO/Vitamin D3 -0.087 0.111 -9999.0 0.0 -0.458 13.0 13.0 SHH Np/Cholesterol/Hhip -0.013 0.088 -9999.0 0.0 -0.239 60.0 60.0 LRP2 -0.003 0.094 -9999.0 0.0 -0.396 26.0 26.0 receptor-mediated endocytosis -0.09 0.112 -9999.0 0.0 -0.478 15.0 15.0 SHH Np/Cholesterol/BOC -0.017 0.092 -9999.0 0.0 -0.235 72.0 72.0 SHH Np/Cholesterol/CDO -0.002 0.075 -9999.0 0.0 -0.224 48.0 48.0 mesenchymal cell differentiation 0.013 0.088 0.238 60.0 -9999.0 0.0 60.0 mol:Vitamin D3 -0.088 0.105 0.37 1.0 -0.376 20.0 21.0 IHH N/PTCH2 -0.02 0.066 -9999.0 0.0 -0.329 14.0 14.0 CDON 0.015 0.068 -9999.0 0.0 -0.453 10.0 10.0 IHH N/PTCH1 -0.099 0.107 -9999.0 0.0 -0.463 11.0 11.0 Megalin/LRPAP1 0.02 0.07 -9999.0 0.0 -0.275 26.0 26.0 PTCH2 0.016 0.067 -9999.0 0.0 -0.427 11.0 11.0 SHH Np/Cholesterol -0.003 0.062 -9999.0 0.0 -0.212 39.0 39.0 PTCH1 -0.101 0.104 -9999.0 0.0 -0.52 8.0 8.0 HHIP -0.007 0.1 -9999.0 0.0 -0.401 29.0 29.0