Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.008 0.113 -9999.0 0.0 -9999.0 0.0 0.0 IHH -0.041 0.216 -9999.0 0.0 -0.666 7.0 7.0 SHH Np/Cholesterol/GAS1 -0.116 0.19 -9999.0 0.0 -0.385 22.0 22.0 LRPAP1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.116 0.189 0.382 22.0 -9999.0 0.0 22.0 SMO/beta Arrestin2 -0.048 0.175 -9999.0 0.0 -0.499 7.0 7.0 SMO -0.062 0.178 -9999.0 0.0 -0.525 7.0 7.0 AKT1 -0.015 0.086 -9999.0 0.0 -0.318 1.0 1.0 ARRB2 0.029 0.026 -9999.0 0.0 -9999.0 0.0 0.0 BOC 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.061 0.175 -9999.0 0.0 -0.517 7.0 7.0 STIL -0.098 0.19 -9999.0 0.0 -0.365 20.0 20.0 DHH N/PTCH2 -0.015 0.148 -9999.0 0.0 -0.481 6.0 6.0 DHH N/PTCH1 -0.039 0.16 -9999.0 0.0 -0.358 13.0 13.0 PIK3CA 0.022 0.004 -9999.0 0.0 -9999.0 0.0 0.0 DHH -0.038 0.191 -9999.0 0.0 -0.641 6.0 6.0 PTHLH -0.019 0.14 -9999.0 0.0 -9999.0 0.0 0.0 determination of left/right symmetry -0.061 0.175 -9999.0 0.0 -0.517 7.0 7.0 PIK3R1 0.023 0.003 -9999.0 0.0 -9999.0 0.0 0.0 skeletal system development -0.018 0.139 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/Hhip -0.014 0.143 -9999.0 0.0 -0.427 7.0 7.0 DHH N/Hhip -0.017 0.148 -9999.0 0.0 -0.485 6.0 6.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.061 0.175 -9999.0 0.0 -0.517 7.0 7.0 pancreas development 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0 HHAT 0.022 0.005 -9999.0 0.0 -9999.0 0.0 0.0 PI3K 0.033 0.007 -9999.0 0.0 -9999.0 0.0 0.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.026 0.176 -9999.0 0.0 -0.641 5.0 5.0 somite specification -0.061 0.175 -9999.0 0.0 -0.517 7.0 7.0 SHH Np/Cholesterol/PTCH1 -0.104 0.196 -9999.0 0.0 -0.375 21.0 21.0 SHH Np/Cholesterol/PTCH2 -0.087 0.175 -9999.0 0.0 -0.383 17.0 17.0 SHH Np/Cholesterol/Megalin -0.357 0.24 -9999.0 0.0 -0.473 49.0 49.0 SHH -0.133 0.206 -9999.0 0.0 -0.484 17.0 17.0 catabolic process -0.013 0.128 -9999.0 0.0 -0.379 7.0 7.0 SMO/Vitamin D3 -0.115 0.21 -9999.0 0.0 -0.409 19.0 19.0 SHH Np/Cholesterol/Hhip -0.09 0.174 -9999.0 0.0 -0.385 17.0 17.0 LRP2 -0.459 0.29 -9999.0 0.0 -0.635 48.0 48.0 receptor-mediated endocytosis -0.302 0.253 -9999.0 0.0 -0.597 22.0 22.0 SHH Np/Cholesterol/BOC -0.086 0.176 -9999.0 0.0 -0.384 17.0 17.0 SHH Np/Cholesterol/CDO -0.085 0.176 -9999.0 0.0 -0.384 17.0 17.0 mesenchymal cell differentiation 0.09 0.173 0.382 17.0 -9999.0 0.0 17.0 mol:Vitamin D3 -0.096 0.203 -9999.0 0.0 -0.375 21.0 21.0 IHH N/PTCH2 -0.012 0.142 -9999.0 0.0 -0.422 7.0 7.0 CDON 0.023 0.012 -9999.0 0.0 -9999.0 0.0 0.0 IHH N/PTCH1 -0.004 0.133 -9999.0 0.0 -0.383 7.0 7.0 Megalin/LRPAP1 -0.334 0.227 -9999.0 0.0 -0.475 47.0 47.0 PTCH2 0.021 0.007 -9999.0 0.0 -9999.0 0.0 0.0 SHH Np/Cholesterol -0.097 0.168 -9999.0 0.0 -0.381 17.0 17.0 PTCH1 -0.013 0.128 -9999.0 0.0 -0.38 7.0 7.0 HHIP 0.011 0.017 -9999.0 0.0 -9999.0 0.0 0.0