E-cadherin signaling in the nascent adherens junction Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations CTTN -0.021 0.102 -9999.0 0.0 -0.51 22.0 22.0 KLHL20 -0.013 0.046 -9999.0 0.0 -0.35 2.0 2.0 CYFIP2 0.004 0.092 -9999.0 0.0 -0.743 8.0 8.0 Rac1/GDP 0.067 0.076 -9999.0 0.0 -9999.0 0.0 0.0 ENAH -0.021 0.102 -9999.0 0.0 -0.51 22.0 22.0 AP1M1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1B 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAP1A 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNB1 0.015 0.003 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP -0.01 0.047 -9999.0 0.0 -9999.0 0.0 0.0 ABI1/Sra1/Nap1 -0.01 0.036 -9999.0 0.0 -0.216 7.0 7.0 E-cadherin/beta catenin/alpha catenin/beta7/alphaE Integrin -0.018 0.084 -9999.0 0.0 -9999.0 0.0 0.0 RAPGEF1 0.053 0.099 -9999.0 0.0 -9999.0 0.0 0.0 CTNND1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of calcium-dependent cell-cell adhesion -0.022 0.106 -9999.0 0.0 -0.534 22.0 22.0 CRK 0.042 0.107 -9999.0 0.0 -0.469 22.0 22.0 E-cadherin/gamma catenin/alpha catenin -0.022 0.104 -9999.0 0.0 -0.491 24.0 24.0 alphaE/beta7 Integrin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 IQGAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 NCKAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP/I-afadin 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 DLG1 -0.021 0.102 -9999.0 0.0 -0.51 22.0 22.0 ChemicalAbstracts:7440-70-2 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:PI-3-4-5-P3 -0.008 0.035 -9999.0 0.0 -9999.0 0.0 0.0 MLLT4 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ARF6/GTP/NME1/Tiam1 -0.002 0.03 -9999.0 0.0 -0.483 2.0 2.0 PI3K -0.01 0.044 -9999.0 0.0 -9999.0 0.0 0.0 ARF6 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 mol:Ca2+ 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin -0.026 0.121 -9999.0 0.0 -0.576 24.0 24.0 TIAM1 0.014 0.033 -9999.0 0.0 -0.742 1.0 1.0 E-cadherin(dimer)/Ca2+ -0.017 0.08 -9999.0 0.0 -9999.0 0.0 0.0 AKT1 -0.005 0.025 -9999.0 0.0 -9999.0 0.0 0.0 PIK3R1 0.014 0.033 -9999.0 0.0 -0.743 1.0 1.0 CDH1 -0.016 0.151 -9999.0 0.0 -0.743 22.0 22.0 RhoA/GDP 0.067 0.076 -9999.0 0.0 -9999.0 0.0 0.0 actin cytoskeleton organization -0.01 0.034 -9999.0 0.0 -0.245 2.0 2.0 CDC42/GDP 0.067 0.076 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/gamma catenin/alpha catenin/p120 catenin -0.014 0.068 -9999.0 0.0 -0.32 24.0 24.0 ITGB7 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RAC1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/beta catenin/alpha catenin/p120 catenin -0.018 0.084 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin -0.017 0.082 -9999.0 0.0 -0.412 22.0 22.0 mol:GDP 0.063 0.087 -9999.0 0.0 -9999.0 0.0 0.0 CDC42/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 JUP 0.011 0.057 -9999.0 0.0 -0.743 3.0 3.0 p120 catenin/RhoA/GDP -0.012 0.06 -9999.0 0.0 -9999.0 0.0 0.0 RAC1/GTP/IQGAP1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C/AP1M1 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 RHOA 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CDC42 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 CTNNA1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 positive regulation of S phase of mitotic cell cycle 0.035 0.063 -9999.0 0.0 -0.263 20.0 20.0 NME1 0.014 0.038 -9999.0 0.0 -0.863 1.0 1.0 clathrin coat assembly -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 TJP1 -0.021 0.102 -9999.0 0.0 -0.51 22.0 22.0 regulation of cell-cell adhesion -0.009 0.041 -9999.0 0.0 -9999.0 0.0 0.0 WASF2 -0.005 0.018 -9999.0 0.0 -9999.0 0.0 0.0 Rap1/GTP -0.011 0.054 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/gamma catenin/alpha catenin/beta7/alphaE Integrin -0.018 0.087 -9999.0 0.0 -0.805 1.0 1.0 CCND1 -0.016 0.065 -9999.0 0.0 -0.334 20.0 20.0 VAV2 0.049 0.104 -9999.0 0.0 -0.501 1.0 1.0 RAP1/GDP -0.011 0.056 -9999.0 0.0 -9999.0 0.0 0.0 adherens junction assembly 0.032 0.109 -9999.0 0.0 -0.492 22.0 22.0 homophilic cell adhesion -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ABI1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PIP5K1C 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 regulation of heterotypic cell-cell adhesion -0.017 0.081 -9999.0 0.0 -0.768 1.0 1.0 E-cadherin/beta catenin -0.019 0.09 -9999.0 0.0 -0.453 22.0 22.0 mol:GTP 0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 SRC -0.021 0.102 -9999.0 0.0 -0.509 22.0 22.0 PIK3CA 0.014 0.033 -9999.0 0.0 -0.743 1.0 1.0 Rac1/GTP -0.021 0.072 -9999.0 0.0 -0.6 1.0 1.0 E-cadherin/beta catenin/alpha catenin -0.02 0.094 -9999.0 0.0 -0.473 22.0 22.0 ITGAE 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 E-cadherin/Ca2+/beta catenin/alpha catenin/p120 catenin -0.023 0.109 -9999.0 0.0 -0.547 22.0 22.0