Signaling events mediated by the Hedgehog family Entity Mean Std Dev Mean of Up Perturbations Number of Up Perturbations Mean of Down Perturbations Number of Down Perturbations Number of Total Perturbations TGFB2 -0.245 0.257 -9999.0 0.0 -0.741 32.0 32.0 IHH -0.096 0.23 -9999.0 0.0 -0.818 47.0 47.0 SHH Np/Cholesterol/GAS1 -0.036 0.124 -9999.0 0.0 -0.45 43.0 43.0 LRPAP1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 dorsoventral neural tube patterning 0.036 0.123 0.447 43.0 -9999.0 0.0 43.0 SMO/beta Arrestin2 -0.145 0.151 -9999.0 0.0 -0.6 33.0 33.0 SMO -0.13 0.19 -9999.0 0.0 -0.635 33.0 33.0 AKT1 -0.04 0.092 -9999.0 0.0 -0.464 1.0 1.0 ARRB2 0.014 0.038 -9999.0 0.0 -0.863 1.0 1.0 BOC 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 ADRBK1 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart looping -0.129 0.187 -9999.0 0.0 -0.623 33.0 33.0 STIL -0.093 0.165 -9999.0 0.0 -0.806 5.0 5.0 DHH N/PTCH2 -0.044 0.161 -9999.0 0.0 -0.63 37.0 37.0 DHH N/PTCH1 -0.159 0.161 -9999.0 0.0 -0.617 37.0 37.0 PIK3CA 0.014 0.033 -9999.0 0.0 -0.743 1.0 1.0 DHH -0.002 0.113 -9999.0 0.0 -0.743 12.0 12.0 PTHLH -0.437 0.407 -9999.0 0.0 -0.741 327.0 327.0 determination of left/right symmetry -0.129 0.187 -9999.0 0.0 -0.623 33.0 33.0 PIK3R1 0.014 0.033 -9999.0 0.0 -0.743 1.0 1.0 skeletal system development -0.432 0.403 -9999.0 0.0 -0.733 327.0 327.0 IHH N/Hhip -0.201 0.308 -9999.0 0.0 -0.649 164.0 164.0 DHH N/Hhip -0.154 0.257 -9999.0 0.0 -0.574 142.0 142.0 mol:Cholesterol -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 heart development -0.129 0.187 -9999.0 0.0 -0.623 33.0 33.0 pancreas development -0.177 0.332 -9999.0 0.0 -0.75 133.0 133.0 HHAT 0.016 0.0 -9999.0 0.0 -9999.0 0.0 0.0 PI3K -0.002 0.034 -9999.0 0.0 -0.556 2.0 2.0 EntrezGene:84976 -0.0 0.0 -9999.0 0.0 -9999.0 0.0 0.0 GAS1 -0.032 0.184 -9999.0 0.0 -0.746 33.0 33.0 somite specification -0.129 0.187 -9999.0 0.0 -0.623 33.0 33.0 SHH Np/Cholesterol/PTCH1 -0.133 0.142 -9999.0 0.0 -0.667 10.0 10.0 SHH Np/Cholesterol/PTCH2 -0.034 0.127 -9999.0 0.0 -0.505 36.0 36.0 SHH Np/Cholesterol/Megalin -0.047 0.148 -9999.0 0.0 -0.481 52.0 52.0 SHH 0.018 0.085 -9999.0 0.0 -0.568 11.0 11.0 catabolic process -0.153 0.193 -9999.0 0.0 -0.65 32.0 32.0 SMO/Vitamin D3 -0.109 0.177 -9999.0 0.0 -0.718 7.0 7.0 SHH Np/Cholesterol/Hhip -0.12 0.206 -9999.0 0.0 -0.458 139.0 139.0 LRP2 -0.05 0.214 -9999.0 0.0 -0.745 46.0 46.0 receptor-mediated endocytosis -0.152 0.176 -9999.0 0.0 -0.764 19.0 19.0 SHH Np/Cholesterol/BOC -0.009 0.063 -9999.0 0.0 -0.443 11.0 11.0 SHH Np/Cholesterol/CDO -0.069 0.18 -9999.0 0.0 -0.526 70.0 70.0 mesenchymal cell differentiation 0.119 0.204 0.455 139.0 -9999.0 0.0 139.0 mol:Vitamin D3 -0.107 0.171 -9999.0 0.0 -0.671 10.0 10.0 IHH N/PTCH2 -0.081 0.214 -9999.0 0.0 -0.616 70.0 70.0 CDON -0.084 0.278 -9999.0 0.0 -0.863 60.0 60.0 IHH N/PTCH1 -0.155 0.194 -9999.0 0.0 -0.66 32.0 32.0 Megalin/LRPAP1 -0.048 0.157 -9999.0 0.0 -0.559 46.0 46.0 PTCH2 -0.026 0.186 -9999.0 0.0 -0.863 25.0 25.0 SHH Np/Cholesterol -0.009 0.065 -9999.0 0.0 -0.454 11.0 11.0 PTCH1 -0.154 0.193 -9999.0 0.0 -0.653 32.0 32.0 HHIP -0.177 0.332 -9999.0 0.0 -0.752 133.0 133.0