rank geneset description genes N_genes mut_tally N n npat nsite nsil n1 n2 n3 n4 n5 n6 p_ns_s p q 1 HIFPATHWAY Under normal conditions, hypoxia inducible factor HIF-1 is degraded; under hypoxic conditions, it activates transcription of genes controlled by hpoxic response elements (HREs). ARNT, ASPH, COPS5, CREB1, EDN1, EP300, EPO, HIF1A, HSPCA, JUN, LDHA, NOS3, P4HB, VEGF, VHL 13 ARNT(1), ASPH(3), COPS5(1), EP300(6), HIF1A(3), JUN(2), NOS3(2), VHL(231) 10473682 249 228 152 15 8 11 29 71 129 1 1.87e-08 <1.00e-15 <5.93e-13 2 VEGFPATHWAY Vascular endothelial growth factor (VEGF) is upregulated by hypoxic conditions and promotes normal blood vessel formation and angiogenesis related to tumor growth or cardiac disease. ARNT, EIF1, EIF1A, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, ELAVL1, FLT1, FLT4, HIF1A, HRAS, KDR, NOS3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PXN, SHC1, VEGF, VHL 25 ARNT(1), EIF1(1), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), FLT1(4), FLT4(6), HIF1A(3), HRAS(1), KDR(5), NOS3(2), PIK3CA(12), PIK3R1(2), PTK2(1), SHC1(2), VHL(231) 21044758 277 238 177 21 13 20 30 81 132 1 2.84e-08 2.33e-15 5.93e-13 3 HSA04120_UBIQUITIN_MEDIATED_PROTEOLYSIS Genes involved in ubiquitin mediated proteolysis ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, BTRC, CDC16, CDC20, CDC23, CDC26, CDC27, CUL1, CUL2, CUL3, FBXW11, FBXW7, FZR1, ITCH, LOC728919, RBX1, SKP1, SKP2, SMURF1, SMURF2, TCEB1, TCEB2, UBA1, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2D4, UBE2E1, UBE2E2, UBE2E3, VHL, WWP1, WWP2 39 ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), BTRC(2), CDC16(2), CDC20(1), CDC23(2), CDC27(2), CUL1(3), CUL2(1), CUL3(5), FBXW11(1), FBXW7(1), FZR1(4), SKP2(1), SMURF2(3), TCEB1(4), TCEB2(1), UBA1(1), UBE2D1(2), UBE2D3(1), UBE2E2(1), VHL(231), WWP2(2) 25294181 281 241 181 20 10 16 29 87 138 1 8.34e-08 2.89e-15 5.93e-13 4 SA_PTEN_PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. AKT1, AKT2, AKT3, BPNT1, GRB2, ILK, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIP3-E, PTEN, PTK2B, RBL2, SHC1, SOS1 16 AKT1(2), AKT2(3), AKT3(2), GRB2(1), ILK(1), MAPK3(1), PDK1(1), PIK3CA(12), PTEN(20), PTK2B(2), RBL2(2), SHC1(2), SOS1(6) 12480838 55 50 52 3 3 13 5 17 16 1 0.000257 1.57e-08 2.43e-06 5 SA_TRKA_RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. AKT1, AKT2, AKT3, ARHA, CDKN1A, ELK1, GRB2, HRAS, MAP2K1, MAP2K2, NGFB, NGFR, NTRK1, PIK3CA, PIK3CD, SHC1, SOS1 15 AKT1(2), AKT2(3), AKT3(2), CDKN1A(1), ELK1(1), GRB2(1), HRAS(1), NGFR(1), NTRK1(4), PIK3CA(12), SHC1(2), SOS1(6) 9746239 36 35 33 1 1 11 5 17 2 0 0.000274 5.19e-06 0.000640 6 CDC42RACPATHWAY PI3 kinase stimulates cell migration by activating cdc42, which activates ARP2/3, which in turn promotes formation of new actin fibers. ACTR2, ACTR3, ARHA, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, PAK1, PDGFRA, PIK3CA, PIK3R1, RAC1, WASL 14 ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), PAK1(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), RAC1(1), WASL(6) 8358184 33 32 30 2 0 9 3 17 4 0 0.00810 2.71e-05 0.00278 7 PTENPATHWAY PTEN suppresses AKT-induced cell proliferation and antagonizes the action of PI3K. AKT1, BCAR1, CDKN1B, FOXO3A, GRB2, ILK, ITGB1, MAPK1, MAPK3, PDK2, PDPK1, PIK3CA, PIK3R1, PTEN, PTK2, SHC1, SOS1, TNFSF6 16 AKT1(2), BCAR1(3), GRB2(1), ILK(1), ITGB1(3), MAPK3(1), PDK2(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTK2(1), SHC1(2), SOS1(6) 11771993 55 50 52 6 3 11 4 19 17 1 0.0177 3.87e-05 0.00341 8 P53HYPOXIAPATHWAY Hypoxia induces p53 accumulation and consequent apoptosis with p53-mediated cell cycle arrest, which is present under conditions of DNA damage. ABCB1, AKT1, ATM, BAX, CDKN1A, CPB2, CSNK1A1, CSNK1D, FHL2, GADD45A, HIC1, HIF1A, HSPA1A, HSPCA, IGFBP3, MAPK8, MDM2, NFKBIB, NQO1, TP53 17 ABCB1(4), AKT1(2), ATM(15), CDKN1A(1), CSNK1A1(1), FHL2(1), HIF1A(3), IGFBP3(1), NFKBIB(1), TP53(10) 12308769 39 35 39 2 2 5 7 13 12 0 0.00367 0.000750 0.0578 9 MTORPATHWAY Mammalian target of rapamycin (mTOR) senses mitogenic factors and nutrients, including ATP, and induces cell proliferation. AKT1, EIF3S10, EIF4A1, EIF4A2, EIF4B, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FKBP1A, FRAP1, MKNK1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1, TSC1, TSC2 21 AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), MKNK1(1), PDK2(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(20), RPS6KB1(1), TSC1(2), TSC2(4) 17176831 58 54 55 6 2 10 5 20 20 1 0.00709 0.00572 0.392 10 IGF1MTORPATHWAY Growth factor IGF-1 activates AKT, Gsk3-beta, and mTOR to promote muscle hypertrophy. AKT1, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF4E, EIF4EBP1, FRAP1, GSK3B, IGF1, IGF1R, INPPL1, PDK2, PDPK1, PIK3CA, PIK3R1, PPP2CA, PTEN, RPS6, RPS6KB1 19 AKT1(2), EIF2B5(1), EIF2S2(1), EIF4E(1), INPPL1(2), PDK2(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), PTEN(20), RPS6KB1(1) 12147172 44 42 41 5 1 9 2 13 18 1 0.0238 0.00815 0.472 11 TERTPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. HDAC1, MAX, MYC, SP1, SP3, TP53, WT1, ZNF42 7 HDAC1(2), MAX(3), MYC(1), SP3(1), TP53(10), WT1(3) 4260168 20 18 20 3 2 2 2 10 4 0 0.246 0.00843 0.472 12 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY The phosphoinositide-3 kinase pathway produces the lipid second messenger PIP3 and regulates cell growth, survival, and movement. A1BG, AKT1, AKT2, AKT3, BAD, BTK, CDKN2A, CSL4, DAF, DAPP1, FOXO1A, GRB2, GSK3A, GSK3B, IARS, IGFBP1, INPP5D, P14, PDK1, PIK3CA, PPP1R13B, PSCD3, PTEN, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SOS1, SOS2, TEC, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 33 A1BG(1), AKT1(2), AKT2(3), AKT3(2), BTK(1), CDKN2A(3), GRB2(1), GSK3A(2), IARS(4), INPP5D(1), PDK1(1), PIK3CA(12), PPP1R13B(3), PTEN(20), RPS6KA1(2), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), TEC(5), YWHAE(1) 22183202 74 65 71 9 3 15 6 26 23 1 0.00983 0.0112 0.572 13 HSA00750_VITAMIN_B6_METABOLISM Genes involved in vitamin B6 metabolism AOX1, PDXK, PDXP, PNPO, PSAT1 5 AOX1(7), PDXK(1), PDXP(1), PSAT1(1) 2946049 10 10 10 0 1 1 0 6 2 0 0.144 0.0160 0.760 14 AKTPATHWAY Second messenger PIP3 promotes cell survival by activating the anti-apoptotic kinase AKT. AKT1, BAD, CASP9, CHUK, FOXO1A, FOXO3A, GH1, GHR, HSPCA, MLLT7, NFKB1, NFKBIA, PDPK1, PIK3CA, PIK3R1, PPP2CA, RELA, TNFSF6, YWHAH 14 AKT1(2), CHUK(1), GHR(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(1) 8733545 21 21 18 0 0 9 2 7 3 0 0.00147 0.0211 0.898 15 EEA1PATHWAY The FYVE-finger proteins EEA1 and HRS are localized to endosome membranes and regulate sorting and ubiquitination in the vesicle transport system. EEA1, EGF, EGFR, HGS, RAB5A, TF, TFRC 7 EEA1(5), EGF(4), EGFR(7), HGS(2), RAB5A(1) 7898260 19 19 18 0 3 1 5 5 5 0 0.0101 0.0219 0.898 16 IFNGPATHWAY IFN gamma signaling pathway IFNG, IFNGR1, IFNGR2, JAK1, JAK2, STAT1 6 IFNGR1(2), IFNGR2(1), JAK1(4), JAK2(5), STAT1(4) 5136758 16 16 16 2 1 0 1 10 4 0 0.398 0.0252 0.971 17 STILBENE_COUMARINE_AND_LIGNIN_BIOSYNTHESIS EPX, GBA3, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TPO, TYR 10 EPX(1), GBA3(2), MPO(4), PRDX1(1), PRDX5(1), TPO(3), TYR(3) 5954630 15 15 15 1 1 2 5 5 2 0 0.0766 0.0325 1.000 18 HSA00950_ALKALOID_BIOSYNTHESIS_I Genes involved in alkaloid biosynthesis I DDC, GOT1, GOT2, TAT, TYR 5 DDC(2), GOT1(2), GOT2(2), TYR(3) 2929848 9 9 9 1 0 0 3 2 4 0 0.444 0.0328 1.000 19 RNAPATHWAY dsRNA-activated protein kinase phosphorylates elF2a, which generally inhibits translation, and activates NF-kB to provoke inflammation. CHUK, DNAJC3, EIF2S1, EIF2S2, MAP3K14, NFKB1, NFKBIA, PRKR, RELA, TP53 9 CHUK(1), DNAJC3(2), EIF2S2(1), MAP3K14(1), NFKB1(1), RELA(1), TP53(10) 6262124 17 16 17 2 2 5 2 4 4 0 0.135 0.0422 1.000 20 ERBB3PATHWAY Neuregulins bind to the receptor tyrosine kinases ErbB3 and ErbB4, surface-localized receptors whose overexpression induces tumor formation. EGF, EGFR, ERBB3, NRG1, UBE2D1 5 EGF(4), EGFR(7), ERBB3(3), NRG1(4), UBE2D1(2) 6368227 20 20 19 3 2 1 4 8 5 0 0.241 0.0453 1.000 21 EGFR_SMRTEPATHWAY EGF receptor activation inhibits SMRT, a transcriptional co-repressor that interacts with transcription factor complexes and gene silencers. EGF, EGFR, MAP2K1, MAP3K1, MAPK14, NCOR2, RARA, RXRA, THRA, THRB, ZNF145 10 EGF(4), EGFR(7), MAP3K1(4), MAPK14(1), NCOR2(4), RARA(4), THRA(2) 10677896 26 26 25 2 1 3 7 8 7 0 0.0341 0.0498 1.000 22 UREACYCLEPATHWAY Ammonia released from amino acid deamination is used to produce carbamoyl phosphate, which is used to convert ornithine to citrulline, from which urea is eventually formed. ARG1, ASL, ASS, CPS1, GLS, GLUD1, GOT1 6 ARG1(1), ASL(1), CPS1(5), GLS(4), GOT1(2) 4816366 13 13 13 1 0 2 1 7 3 0 0.207 0.0514 1.000 23 CYSTEINE_METABOLISM CARS, CTH, GOT1, GOT2, LDHA, LDHB, LDHC, MPST 8 CARS(4), CTH(1), GOT1(2), GOT2(2), LDHB(1), LDHC(1), MPST(2) 4180017 13 13 13 2 1 0 2 6 4 0 0.471 0.0584 1.000 24 CTLA4PATHWAY T cell activation requires interaction with an antigen-MHC-I complex on an antigen-presenting cell (APC), as well as CD28 interaction with the APC's CD80 or 86. CD28, CD3D, CD3E, CD3G, CD3Z, CD80, CD86, CTLA4, GRB2, HLA-DRA, HLA-DRB1, ICOS, ICOSL, IL2, ITK, LCK, PIK3CA, PIK3R1, PTPN11, TRA@, TRB@ 17 CD28(1), CD3E(2), CD3G(1), CD86(1), GRB2(1), HLA-DRA(1), ITK(1), PIK3CA(12), PIK3R1(2), PTPN11(1) 7740259 23 22 20 3 1 9 3 7 3 0 0.0789 0.0621 1.000 25 CYANOAMINO_ACID_METABOLISM ATP6V0C, SHMT1, GBA3, GGT1, SHMT1, SHMT2 5 GBA3(2), GGT1(2), SHMT1(2), SHMT2(3) 2522169 9 9 9 2 0 1 3 2 3 0 0.523 0.0622 1.000 26 ARFPATHWAY Cyclin-dependent kinase inhibitor 2A is a tumor suppressor that induces G1 arrest and can activate the p53 pathway, leading to G2/M arrest. ABL1, CDKN2A, E2F1, MDM2, MYC, PIK3CA, PIK3R1, POLR1A, POLR1B, POLR1C, POLR1D, RAC1, RB1, TBX2, TP53, TWIST1 16 ABL1(4), CDKN2A(3), E2F1(1), MYC(1), PIK3CA(12), PIK3R1(2), POLR1A(2), POLR1B(2), POLR1C(3), RAC1(1), RB1(1), TP53(10) 12131686 42 38 38 5 3 12 4 17 6 0 0.0128 0.0701 1.000 27 NICOTINATE_AND_NICOTINAMIDE_METABOLISM AOX1, CD38, ENPP1, ENPP3, NADSYN1, NMNAT1, NMNAT2, NNMT, NNT, NP, NT5C, NT5E, NT5M, QPRT 13 AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NNMT(1), NNT(6), NT5M(2), QPRT(1) 8974205 20 20 20 1 0 3 3 12 2 0 0.0354 0.0850 1.000 28 BBCELLPATHWAY Fas ligand expression by T cells induces apoptosis in Fas-expressing, inactive B cells. CD28, CD4, HLA-DRA, HLA-DRB1, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 4 CD28(1), CD4(2), HLA-DRA(1) 1276465 4 4 4 0 1 1 0 1 1 0 0.324 0.0863 1.000 29 HCMVPATHWAY Cytomegalovirus activates MAP kinase pathways in the host cell, inducing transcription of viral genes. AKT1, CREB1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NFKB1, PIK3CA, PIK3R1, RB1, RELA, SP1 16 AKT1(2), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RB1(1), RELA(1) 12208236 29 29 26 3 2 10 2 12 3 0 0.0258 0.0929 1.000 30 ACETAMINOPHENPATHWAY Acetaminophen selectively inhibits Cox-3, which is localized to the brain, and yields the toxic metabolite NAPQI when processed by CAR in the liver. CYP1A2, CYP2E1, CYP3A, NR1I3, PTGS1, PTGS2 5 CYP1A2(3), CYP2E1(1), NR1I3(1), PTGS1(1), PTGS2(4) 3264531 10 10 10 2 1 1 1 4 3 0 0.529 0.0996 1.000 31 CHREBPPATHWAY Carbohydrate responsive element binding protein (chREBP) is a transcription factor inhibited by cAMP and activated by high carbohydrate levels. ADCY1, BG1, BUCS1, GNAS, GNB1, GNGT1, PPP2CA, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, WBSCR14 17 ADCY1(1), GNAS(4), GNB1(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1) 9330868 22 22 22 2 2 2 1 14 3 0 0.126 0.107 1.000 32 LYSINE_BIOSYNTHESIS AADAT, AASDH, AASDHPPT, AASS, KARS 5 AASDH(3), AASDHPPT(2), AASS(4), KARS(1) 4362596 10 10 10 1 0 2 0 3 5 0 0.418 0.111 1.000 33 TCAPOPTOSISPATHWAY HIV infection upregulates Fas ligand in macrophages and CD4 in helper T cells, leading to widespread Fas-induced T cell apoptosis. CCR5, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, TNFRSF6, TNFSF6, TRA@, TRB@ 6 CD28(1), CD3E(2), CD3G(1), CD4(2) 2024848 6 5 6 0 1 2 1 2 0 0 0.121 0.121 1.000 34 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway AKT1, AKT2, AKT3, BRD4, CAP1, CBL, CDC42, CDKN2A, F2RL2, FLOT1, FLOT2, FOXO1A, GRB2, GSK3A, GSK3B, IGFBP1, INPPL1, IRS1, IRS2, IRS4, LNPEP, MAPK1, MAPK3, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PIK3R1, PPYR1, PSCD3, PTEN, PTPN1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SERPINB6, SFN, SHC1, SLC2A4, SORBS1, SOS1, SOS2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 48 AKT1(2), AKT2(3), AKT3(2), BRD4(5), CBL(1), CDC42(1), CDKN2A(3), F2RL2(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), LNPEP(3), MAPK3(1), PARD3(2), PDK1(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SORBS1(1), SOS1(6), SOS2(1), YWHAE(1) 35289010 84 77 81 8 5 15 10 30 23 1 0.000494 0.127 1.000 35 HSA00300_LYSINE_BIOSYNTHESIS Genes involved in lysine biosynthesis AADAT, AASDHPPT, AASS, KARS 4 AASDHPPT(2), AASS(4), KARS(1) 2965715 7 7 7 1 0 1 0 2 4 0 0.574 0.129 1.000 36 TCRMOLECULE T Cell Receptor and CD3 Complex CD3D, CD3E, CD3G, CD3Z, TRA@, TRB@ 3 CD3E(2), CD3G(1) 724975 3 2 3 0 0 1 1 1 0 0 0.376 0.150 1.000 37 DREAMPATHWAY The transcription factor DREAM blocks expression of the prodynorphin gene, which encodes the ligand of an opioid receptor that blocks pain signaling. CREB1, CREM, CSEN, FOS, JUN, MAPK3, OPRK1, POLR2A, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 13 CREM(1), JUN(2), MAPK3(1), POLR2A(6), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 7845704 19 18 19 2 4 2 2 9 2 0 0.0923 0.150 1.000 38 HSA00130_UBIQUINONE_BIOSYNTHESIS Genes involved in ubiquinone biosynthesis COQ2, COQ3, COQ5, COQ6, COQ7, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA12, NDUFA13, NDUFB11 8 COQ5(2), COQ6(2), NDUFA13(2) 2543806 6 6 6 0 2 1 0 2 1 0 0.182 0.153 1.000 39 TOB1PATHWAY TGF-beta signaling activates SMADs, which interact with intracellular Tob to maintain unstimulated T cells by repressing IL-2 expression. CD28, CD3D, CD3E, CD3G, CD3Z, IFNG, IL2, IL2RA, IL4, MADH3, MADH4, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, TOB1, TOB2, TRA@, TRB@ 16 CD28(1), CD3E(2), CD3G(1), IL2RA(2), IL4(1), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1), TOB1(2), TOB2(3) 6625463 17 16 17 2 1 3 4 7 2 0 0.167 0.156 1.000 40 FOLATE_BIOSYNTHESIS ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, DHFR, FPGS, GCH1, GGH, SPR 9 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), FPGS(2) 3715075 12 11 12 2 1 3 1 6 1 0 0.241 0.157 1.000 41 AKAP13PATHWAY A-kinase anchor protein 13 (AKAP13) localizes protein kinase A holoenzyme and is a nucleotide exchange factor for Rho/Rac. AKAP13, ARHA, EDG2, EDG4, EDG7, GNA12, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B 7 AKAP13(5), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1) 6208875 13 13 13 1 2 2 2 7 0 0 0.107 0.158 1.000 42 HSA00401_NOVOBIOCIN_BIOSYNTHESIS Genes involved in novobiocin biosynthesis GOT1, GOT2, TAT 3 GOT1(2), GOT2(2) 1638319 4 4 4 1 0 0 2 0 2 0 0.685 0.169 1.000 43 CARM1PATHWAY The methyltransferase CARM1 interacts with transcription factors such as CBP/p300 and methylates histones H3 and H4. CARM1, CREB1, CREBBP, EP300, NCOA3, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RARA, RXRA 13 CREBBP(4), EP300(6), NCOA3(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RARA(4) 12711401 27 27 27 2 2 1 7 16 1 0 0.0208 0.171 1.000 44 GLYCOSAMINOGLYCAN_DEGRADATION ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, IDS, IDUA, LCT, NAGLU 11 ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), IDS(2), IDUA(1), LCT(2) 8830693 22 18 20 2 4 2 4 10 2 0 0.0329 0.175 1.000 45 ASBCELLPATHWAY B cells require interaction with helper T cells to produce antigen-specific immunoglobulins as a key element of the human immune response. CD28, CD4, CD80, HLA-DRA, HLA-DRB1, IL10, IL2, IL4, TNFRSF5, TNFRSF6, TNFSF5, TNFSF6 8 CD28(1), CD4(2), HLA-DRA(1), IL4(1) 2269336 5 5 5 1 1 1 1 1 1 0 0.491 0.179 1.000 46 PTC1PATHWAY The binding of extracellular signaling protein Sonic hedgehog to the Patched receptor (Ptc1) allows progression through G1 and may inhibit the G2/M transition. CCNB1, CCNH, CDC2, CDC25A, CDC25B, CDC25C, CDK7, MNAT1, PTCH, SHH, XPO1 9 CCNH(1), CDC25A(1), CDC25C(2), SHH(1), XPO1(6) 5348304 11 11 11 1 0 0 4 6 1 0 0.206 0.191 1.000 47 IL17PATHWAY Activated T cells secrete IL-17, which stimulates fibroblasts and other cells to secrete inflammatory and hematopoietic cytokines. CD2, CD34, CD3D, CD3E, CD3G, CD3Z, CD4, CD58, CD8A, CSF3, IL17, IL3, IL6, IL8, KITLG, TRA@, TRB@ 13 CD34(1), CD3E(2), CD3G(1), CD4(2), IL3(1), KITLG(2) 3881708 9 8 9 1 0 2 1 5 1 0 0.349 0.222 1.000 48 BETAOXIDATIONPATHWAY Beta-Oxidation of Fatty Acids ACADL, ACADM, ACADS, ACAT1, ECHS1, HADHA 6 ACADM(1), ACADS(2), ECHS1(2), HADHA(1) 3351862 6 6 5 0 3 0 2 1 0 0 0.105 0.224 1.000 49 HSA00531_GLYCOSAMINOGLYCAN_DEGRADATION Genes involved in glycosaminoglycan degradation ARSB, GALNS, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, NAGLU, SPAM1 17 ARSB(1), GALNS(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), SPAM1(4) 12652402 34 27 32 4 6 5 5 15 3 0 0.0155 0.227 1.000 50 HBXPATHWAY Hbx is a hepatitis B protein that activates a number of transcription factors, possibly by inducing calcium release from the mitochondrion to the cytoplasm. CREB1, GRB2, HBXIP, HRAS, PTK2B, SHC1, SOS1, SRC 8 GRB2(1), HBXIP(1), HRAS(1), PTK2B(2), SHC1(2), SOS1(6), SRC(2) 5343368 15 15 15 3 1 6 2 6 0 0 0.277 0.228 1.000 51 CK1PATHWAY Caseine kinase 1 (CK1) and cdk5 phosphorylate DARPP32 in the dopamine signaling pathway. CDK5, CDK5R1, CSNK1D, DRD1, DRD2, GRM1, PLCB1, PPP1CA, PPP1R1B, PPP2CA, PPP3CA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 17 DRD1(1), DRD2(1), GRM1(4), PLCB1(1), PPP1R1B(1), PPP2CA(1), PPP3CA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 9796405 19 19 19 1 3 0 0 12 4 0 0.0483 0.245 1.000 52 ARGININECPATHWAY Related catabolic pathways process arginine, histidine, glutamine, and proline through glutamate to alpha-ketoglutamate, which feeds into the citric acid cycle. ALDH4A1, ARG1, GLS, GLUD1, OAT, PRODH 6 ALDH4A1(1), ARG1(1), GLS(4), PRODH(1) 3471066 7 7 7 0 0 1 2 3 1 0 0.179 0.252 1.000 53 HSA00471_D_GLUTAMINE_AND_D_GLUTAMATE_METABOLISM Genes involved in D-glutamine and D-glutamate metabolism GLS, GLS2, GLUD1, GLUD2 4 GLS(4), GLS2(2) 2752495 6 6 6 0 0 1 0 5 0 0 0.272 0.261 1.000 54 PLCEPATHWAY Gs-coupled receptors activate adenylyl cyclase, which activates Epac1, leading to the stimulation of PLC and subsequent DAG and IP3 production. ADCY1, ADRB2, GNAS, PLCE1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTGER1, RAP2B 11 ADCY1(1), ADRB2(2), GNAS(4), PLCE1(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAP2B(2) 8918662 21 21 21 3 2 1 2 11 5 0 0.363 0.274 1.000 55 UBIQUITIN_MEDIATED_PROTEOLYSIS CDC34, HIP2, NRF1, UBE1, UBE2A, UBE2B, UBE2C, UBE2D1, UBE2D2, UBE2D3, UBE2E1, UBE2E3, UBE2G1, UBE2G2, UBE2G2, TAX1BP3, UBE2H, UBE2I, UBE2J1, UBE2J2, UBE2L3, UBE2L6, UBE2M, UBE2N, UBE2S, UBE3A 23 NRF1(1), UBE2A(2), UBE2D1(2), UBE2D3(1), UBE2H(2), UBE2J1(1), UBE2J2(1), UBE2N(1), UBE3A(1) 6501222 12 12 12 1 1 1 1 5 4 0 0.250 0.277 1.000 56 HSA00472_D_ARGININE_AND_D_ORNITHINE_METABOLISM Genes involved in D-arginine and D-ornithine metabolism DAO 1 DAO(1) 450414 1 1 1 0 0 0 1 0 0 0 0.751 0.277 1.000 57 BOTULINPATHWAY Blockade of Neurotransmitter Relase by Botulinum Toxin CHRM1, CHRNA1, SNAP25, STX1A, VAMP2 5 CHRNA1(3), STX1A(1) 1996435 4 4 4 1 0 0 0 2 2 0 0.856 0.281 1.000 58 RASPATHWAY Ras activation stimulates many signaling cascades, including PI3K/AKT activation to inhibit apoptosis. AKT1, ARHA, BAD, BCL2L1, CASP9, CDC42, CHUK, ELK1, H2AFX, HRAS, MAP2K1, MAPK3, MLLT7, NFKB1, PIK3CA, PIK3R1, RAC1, RAF1, RALA, RALBP1, RALGDS, RELA, RHOA 21 AKT1(2), CDC42(1), CHUK(1), ELK1(1), HRAS(1), MAPK3(1), NFKB1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RALBP1(1), RELA(1) 11917286 25 25 22 3 1 10 2 9 3 0 0.0590 0.291 1.000 59 CREBPATHWAY CREB is a transcription factor that binds to cAMP-responsive elements (CREs) to activate transcription in response to extracellular signaling. ADCY1, AKT1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, GNAS, GRB2, HRAS, MAPK1, MAPK14, MAPK3, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAC1, RPS6KA1, RPS6KA5, SOS1 26 ADCY1(1), AKT1(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), GNAS(4), GRB2(1), HRAS(1), MAPK14(1), MAPK3(1), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RAC1(1), RPS6KA1(2), SOS1(6) 17831564 48 47 45 7 4 10 4 27 3 0 0.0559 0.301 1.000 60 CBLPATHWAY Activated EGF receptors undergo endocytosis into clathrin-coated vesicles, where they are recycled to the membrane or ubiquitinated by Cbl. CBL, CSF1R, EGF, EGFR, GRB2, MET, PDGFRA, PRKCA, PRKCB1, SH3GLB1, SH3GLB2, SH3KBP1, SRC 12 CBL(1), CSF1R(5), EGF(4), EGFR(7), GRB2(1), MET(3), PDGFRA(7), SH3GLB1(1), SH3GLB2(1), SH3KBP1(1), SRC(2) 12092696 33 31 32 5 1 6 4 16 6 0 0.124 0.302 1.000 61 HSA00930_CAPROLACTAM_DEGRADATION Genes involved in caprolactam degradation AKR1A1, ASAHL, ECHS1, EHHADH, HADH, HADHA, HSD17B10, HSD17B4, NTAN1, SIRT1, SIRT2, SIRT5, SIRT7, VNN2, VNN3 13 ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HSD17B4(1), SIRT1(4), SIRT5(1), SIRT7(1) 7386124 13 12 13 1 2 4 3 2 2 0 0.0801 0.302 1.000 62 METHANE_METABOLISM ADH5, ATP6V0C, SHMT1, CAT, EPX, LPO, MPO, PRDX1, PRDX2, PRDX5, PRDX6, SHMT1, SHMT2, TPO 13 ADH5(1), CAT(2), EPX(1), MPO(4), PRDX1(1), PRDX5(1), SHMT1(2), SHMT2(3), TPO(3) 7260897 18 18 18 3 1 3 4 7 3 0 0.240 0.306 1.000 63 HSA00625_TETRACHLOROETHENE_DEGRADATION Genes involved in tetrachloroethene degradation AKR1B10, EPHX2, HSD3B7, RDH11, RDH12, RDH13, RDH14 7 AKR1B10(2), EPHX2(1), RDH11(3) 2927708 6 6 6 0 1 0 1 4 0 0 0.234 0.306 1.000 64 PMLPATHWAY Ring-shaped PML nuclear bodies regulate transcription and are required co-activators in p53- and DAXX-mediated apoptosis. CREBBP, DAXX, HRAS, PAX3, PML, PRAM-1, RARA, RB1, SIRT1, SP100, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TP53, UBL1 13 CREBBP(4), DAXX(4), HRAS(1), PAX3(1), PML(3), RARA(4), RB1(1), SIRT1(4), SP100(1), TNFRSF1A(1), TP53(10) 11424579 34 31 34 5 3 5 7 15 4 0 0.0744 0.318 1.000 65 41BBPATHWAY TNF-type receptor 4-1BB is bound by TRAF1 to activate the MAP kinase pathway in activated T cells. ATF2, CHUK, IFNG, IKBKB, IL2, IL4, JUN, MAP3K1, MAP3K5, MAP4K5, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, TNFRSF9, TNFSF9, TRAF2 18 ATF2(1), CHUK(1), IL4(1), JUN(2), MAP3K1(4), MAP3K5(5), MAP4K5(4), MAPK14(1), NFKB1(1), RELA(1), TNFRSF9(1), TNFSF9(1) 12202915 23 22 23 2 0 3 1 13 6 0 0.170 0.319 1.000 66 AMIPATHWAY Endogenous anti-thrombosis pathways are overwhelmed in plaque-narrowed blood vessels, resulting in potentially lethal myocardial infarction. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6) 13758110 34 29 34 3 2 5 2 22 3 0 0.0390 0.327 1.000 67 CSKPATHWAY Csk inhibits T-cell activation by phosphorylating Lck; Csk is regulated by cAMP-dependent kinases and is opposed by the T-cell activator CD45. ADCY1, CD3D, CD3E, CD3G, CD3Z, CD4, CREBBP, CSK, GNAS, GNB1, GNGT1, HLA-DRA, HLA-DRB1, LCK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTPRC, TRA@, TRB@, ZAP70 21 ADCY1(1), CD3E(2), CD3G(1), CD4(2), CREBBP(4), CSK(2), GNAS(4), GNB1(2), HLA-DRA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTPRC(6) 13758110 34 29 34 3 2 5 2 22 3 0 0.0390 0.327 1.000 68 ALKALOID_BIOSYNTHESIS_II ABP1, AOC2, AOC3, CES1, ESD 5 ABP1(5), AOC2(2), AOC3(1), CES1(2) 3505264 10 9 10 2 0 2 2 6 0 0 0.360 0.338 1.000 69 SLRPPATHWAY Small leucine-rich proteoglycans (SLRPs) interact with and reorganize collagen fibers in the extracellular matrix. BGN, DCN, DSPG3, FMOD, KERA, LUM 5 DCN(3), FMOD(2), LUM(1) 2235482 6 6 6 2 0 1 0 4 1 0 0.681 0.341 1.000 70 CTLPATHWAY Cytotoxic T lymphocytes induce apoptosis in infected cells presenting antigen-MHC-I complexes via the perforin and Fas/Fas ligand pathways. B2M, CD3D, CD3E, CD3G, CD3Z, GZMB, HLA-A, ICAM1, ITGAL, ITGB2, PRF1, TNFRSF6, TNFSF6, TRA@, TRB@ 10 B2M(2), CD3E(2), CD3G(1), ITGAL(4), ITGB2(1), PRF1(1) 5137727 11 9 11 1 1 3 2 4 1 0 0.141 0.353 1.000 71 PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS ENO1, ENO2, ENO3, FARS2, FARSLB, GOT1, GOT2, PAH, TAT, YARS 9 ENO1(2), ENO2(1), GOT1(2), GOT2(2), PAH(3), YARS(1) 5167192 11 11 11 2 0 0 4 4 3 0 0.457 0.362 1.000 72 ST_INTERFERON_GAMMA_PATHWAY The interferon gamma pathway resembles the JAK-STAT pathway and activates STAT transcription factors. CISH, IFNG, IFNGR1, JAK1, JAK2, PLA2G2A, PTPRU, REG1A, STAT1, STATIP1 9 IFNGR1(2), JAK1(4), JAK2(5), PTPRU(4), STAT1(4) 7072431 19 17 19 3 1 0 1 13 4 0 0.445 0.362 1.000 73 CAPROLACTAM_DEGRADATION AKR1A1, ECHS1, EHHADH, HADHA, SDS 5 ECHS1(2), EHHADH(2), HADHA(1) 3042194 5 5 5 0 1 2 1 1 0 0 0.153 0.363 1.000 74 RECKPATHWAY RECK is a membrane-anchored inhibitor of matrix metalloproteinases, which are expressed by tumor cells and promote metastasis. HRAS, MMP14, MMP2, MMP9, RECK, TIMP1, TIMP2, TIMP3, TIMP4 9 HRAS(1), MMP14(1), MMP2(4), MMP9(1), RECK(1) 4647674 8 8 8 1 0 2 1 3 2 0 0.375 0.367 1.000 75 AKAPCENTROSOMEPATHWAY Protein Kinase A at the Centrosome AKAP9, ARHA, CDC2, MAP2, PCNT1, PCNT2, PPP1CA, PPP2CA, PRKACB, PRKACG, PRKAG1, PRKAR2A, PRKAR2B, PRKCE, PRKCL1 10 AKAP9(11), MAP2(2), PPP2CA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAR2B(1), PRKCE(2) 11238170 24 23 24 3 4 1 0 15 4 0 0.232 0.373 1.000 76 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_NEOLACTOSERIES ABO, B3GNT1, FUT1, FUT2, FUT9, GCNT2, ST8SIA1 7 ABO(1), FUT1(1), GCNT2(4), ST8SIA1(2) 3625939 8 8 8 2 1 1 1 3 2 0 0.593 0.376 1.000 77 HSA00550_PEPTIDOGLYCAN_BIOSYNTHESIS Genes involved in peptidoglycan biosynthesis GLUL, PGLYRP2 2 PGLYRP2(2) 1069531 2 2 2 0 0 1 0 1 0 0 0.498 0.382 1.000 78 HSA00680_METHANE_METABOLISM Genes involved in methane metabolism ADH5, CAT, EPX, LPO, MPO, MTHFR, PRDX6, SHMT1, SHMT2, TPO 10 ADH5(1), CAT(2), EPX(1), MPO(4), MTHFR(1), SHMT1(2), SHMT2(3), TPO(3) 7138474 17 17 17 3 1 3 3 7 3 0 0.287 0.384 1.000 79 THELPERPATHWAY Helper T cells coordinate the actions of B cells, macrophages, and other immune cells via surface molecules such as T cell receptor/CD3 and their characteristic marker CD4. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD4, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(2), CD3G(1), CD4(2), ITGAL(4), ITGB2(1), PTPRC(6) 6984514 17 15 17 3 2 3 2 9 1 0 0.253 0.391 1.000 80 SALMONELLAPATHWAY Salmonella induces membrane ruffling in infected cells via bacterial proteins including SipA, SipC, and SopE, which alter actin structure. ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, CDC42, RAC1, WASF1, WASL 12 ACTR2(1), ARPC1B(1), ARPC2(1), CDC42(1), RAC1(1), WASL(6) 5054098 11 11 11 2 0 3 0 8 0 0 0.439 0.403 1.000 81 INOSITOL_METABOLISM ALDH6A1, ALDOA, ALDOB, ALDOC, TPI1 5 ALDOA(2), ALDOB(3), TPI1(1) 2389282 6 6 6 4 0 0 1 1 4 0 0.993 0.404 1.000 82 GSPATHWAY Activated G-protein coupled receptors stimulate cAMP production and thus activate protein kinase A, involved in a number of signal transduction pathways. ADCY1, GNAS, GNB1, GNGT1, PRKACA, PRKAR1A 6 ADCY1(1), GNAS(4), GNB1(2), PRKACA(1), PRKAR1A(2) 3885215 10 10 10 2 0 1 0 8 1 0 0.676 0.411 1.000 83 MSPPATHWAY Macrophage stimulating protein is synthesized as pro-MSP by the liver and, on proteolysis, binds to monocyte receptor kinase RON to induce macrophage development. CCL2, CSF1, IL1B, MST1, MST1R, TNF 6 CCL2(1), MST1(1), MST1R(4) 3737496 6 6 5 1 0 0 4 1 1 0 0.523 0.419 1.000 84 CACAMPATHWAY Calcium functions as a second messenger activating the calcium/calmodulin-dependent kinases, which phosphorylate targets such as CREB. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CAMKK1, CAMKK2, CREB1, SYT1 14 CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CAMKK1(1), CAMKK2(2), SYT1(1) 7152685 12 12 12 0 1 1 1 7 2 0 0.0891 0.420 1.000 85 GLEEVECPATHWAY The drug Gleevec specifically targets the abnormal bcr-abl protein, an apoptosis inhibitor present in chronic myeloid leukemia. AKT1, BCL2, BCR, CRKL, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, MYC, PIK3CA, PIK3R1, RAF1, SOS1, STAT1, STAT5A, STAT5B 22 AKT1(2), BCR(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAP3K1(4), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), SOS1(6), STAT1(4), STAT5B(1) 16989027 43 41 40 6 2 9 4 24 4 0 0.0461 0.434 1.000 86 AGPCRPATHWAY G-protein coupled receptors (GPCRs) transduce extracellular signals across the plasma membrane; attenuation occurs by signal molecule degradation or receptor-mediated endocytosis. ARRB1, GNAS, GNB1, GNGT1, GPRK2L, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1 11 GNAS(4), GNB1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 5851185 15 15 15 3 2 1 0 11 1 0 0.564 0.444 1.000 87 HSA04140_REGULATION_OF_AUTOPHAGY Genes involved in regulation of autophagy ATG12, ATG3, ATG5, ATG7, BECN1, GABARAP, GABARAPL1, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNG, INS, LOC441925, PIK3C3, PIK3R4, PRKAA1, PRKAA2, ULK1, ULK2, ULK3 29 ATG3(2), ATG7(3), BECN1(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), PIK3C3(1), PIK3R4(3), ULK1(1), ULK2(1), ULK3(3) 13185203 23 23 23 2 1 3 1 13 5 0 0.120 0.448 1.000 88 TCRAPATHWAY The kinases Lck and Fyn phosphorylate and activate the T cell receptor, which recognizes antigen-bound MHCII and leads to T cell activation. CD3D, CD3E, CD3G, CD3Z, CD4, FYN, HLA-DRA, HLA-DRB1, LCK, PTPRC, TRA@, TRB@, ZAP70 10 CD3E(2), CD3G(1), CD4(2), FYN(1), HLA-DRA(1), PTPRC(6) 5358108 13 11 13 2 0 2 1 8 2 0 0.424 0.453 1.000 89 HSA00520_NUCLEOTIDE_SUGARS_METABOLISM Genes involved in nucleotide sugars metabolism GALE, GALT, TGDS, UGDH, UGP2, UXS1 6 GALE(1), GALT(2), UGP2(1), UXS1(1) 3135576 5 5 5 1 0 0 3 2 0 0 0.562 0.466 1.000 90 SA_BONE_MORPHOGENETIC Bone morphogenetic protein binds to its receptor to induce ectopic bone formation and promote development of the viscera. BMP1, BMPR1A, BMPR1B, BMPR2, MADH1, MADH4, MADH6 4 BMP1(2), BMPR1B(1), BMPR2(4) 3811083 7 6 7 0 0 0 1 4 2 0 0.162 0.466 1.000 91 NUCLEOTIDE_SUGARS_METABOLISM GALE, GALT, TGDS, UGDH, UXS1 5 GALE(1), GALT(2), UXS1(1) 2482167 4 4 4 1 0 0 2 2 0 0 0.701 0.475 1.000 92 PLK3PATHWAY Active Plk3 phosphorylates CDC25c, blocking the G2/M transition, and phosphorylates p53 to induce apoptosis. ATM, ATR, CDC25C, CHEK1, CHEK2, CNK, TP53, YWHAH 7 ATM(15), ATR(5), CDC25C(2), CHEK2(1), TP53(10) 9985565 33 28 33 5 2 3 5 13 10 0 0.239 0.476 1.000 93 GCRPATHWAY Corticosteroids activate the glucocorticoid receptor (GR), which inhibits NF-kB and activates Annexin-1, thus inhibiting the inflammatory response. ADRB2, AKT1, ANXA1, CALM1, CALM2, CALM3, CRN, GNAS, GNB1, GNGT1, HSPCA, NFKB1, NOS3, NPPA, NR3C1, PIK3CA, PIK3R1, RELA, SYT1 17 ADRB2(2), AKT1(2), CALM2(1), GNAS(4), GNB1(2), NFKB1(1), NOS3(2), NPPA(1), PIK3CA(12), PIK3R1(2), RELA(1), SYT1(1) 10975684 31 31 28 5 1 11 3 13 3 0 0.117 0.476 1.000 94 GSK3PATHWAY Bacterial lipopolysaccharide activates AKT to promote the survival and activation of macrophages and inhibits Gsk3-beta to promote beta-catenin accumulation in the nucleus. AKT1, APC, AXIN1, CCND1, CD14, CTNNB1, DVL1, FZD1, GJA1, GNAI1, GSK3B, IRAK1, LBP, LEF1, LY96, MYD88, NFKB1, PDPK1, PIK3CA, PIK3R1, PPP2CA, PRKR, RELA, TIRAP, TLR4, TOLLIP, WNT1 26 AKT1(2), APC(6), AXIN1(2), CTNNB1(1), DVL1(1), FZD1(2), GNAI1(1), IRAK1(3), LBP(1), LEF1(1), LY96(1), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP2CA(1), RELA(1), TLR4(2) 18561496 40 40 37 5 2 12 6 16 4 0 0.00712 0.480 1.000 95 ACTINYPATHWAY The Arp 2/3 complex localizes to the Y-junction of polymerizing actin fibers that enable lamellipod extension and consequent cell motility. ABI-2, ACTA1, ACTR2, ACTR3, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, NCK1, NCKAP1, NTRK1, PIR, PSMA7, RAC1, WASF1, WASF2, WASF3, WASL 18 ACTR2(1), ARPC1B(1), ARPC2(1), NCKAP1(1), NTRK1(4), RAC1(1), WASF2(1), WASF3(1), WASL(6) 9435096 17 17 17 2 0 3 1 12 1 0 0.229 0.510 1.000 96 SELENOAMINO_ACID_METABOLISM AHCY, CBS, CTH, GGT1, MARS, MARS2, MAT1A, MAT2B, PAPSS1, PAPSS2, SCLY, SEPHS1 12 CTH(1), GGT1(2), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), SEPHS1(1) 7505152 14 14 14 2 2 0 4 5 3 0 0.240 0.513 1.000 97 NUCLEOTIDE_METABOLISM ADSL, ADSS, DHFR, HPRT1, IMPDH1, MTHFD2, NME2, OAZ1, POLA, POLB, POLD1, POLG, PRPS2, RRM1, SAT, SRM 14 ADSL(1), HPRT1(1), IMPDH1(1), POLB(1), POLD1(3), POLG(2), PRPS2(2), RRM1(2) 7707287 13 13 13 2 2 3 1 5 2 0 0.215 0.515 1.000 98 SHHPATHWAY Sonic hedgehog (Shh) signaling in the developing CNS induces neuronal proliferation via interaction with the patched (Ptc-1) and smoothened receptors. DYRK1A, DYRK1B, GLI, GLI2, GLI3, GSK3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTCH, SHH, SMO, SUFU 14 DYRK1A(2), GLI2(4), GLI3(3), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SHH(1), SMO(3) 9620228 22 21 22 4 4 1 2 13 2 0 0.291 0.533 1.000 99 INFLAMPATHWAY Interleukins and TNF serve as signals to coordinate the inflammatory response, in which macrophages recruit and activate neutrophils, fibroblasts, and T cells. CD4, CSF1, CSF2, CSF3, HLA-DRA, HLA-DRB1, IFNA1, IFNB1, IFNG, IL10, IL11, IL12A, IL12B, IL13, IL15, IL1A, IL2, IL3, IL4, IL5, IL6, IL7, IL8, LTA, PDGFA, TGFB1, TGFB2, TGFB3, TNF 29 CD4(2), HLA-DRA(1), IFNA1(2), IFNB1(2), IL15(1), IL3(1), IL4(1), LTA(1), TGFB2(2), TGFB3(1) 7932143 14 14 14 2 0 5 1 7 1 0 0.172 0.535 1.000 100 SMALL_LIGAND_GPCRS C9orf47, CNR1, CNR2, DNMT1, EDG1, EDG2, EDG5, EDG6, MTNR1A, MTNR1B, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, TBXA2R 13 CNR1(1), CNR2(1), DNMT1(6), MTNR1B(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), TBXA2R(1) 6477318 17 17 17 4 1 2 4 7 3 0 0.473 0.536 1.000 101 CFTRPATHWAY The cAMP-regulated chloride channel CFTR (deficient in cystic fibrosis) is regulated by the surface-localized beta-adrenergic receptor. ADCY1, ADRB2, CFTR, GNAS, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, SLC9A3R1, VIL2 11 ADCY1(1), ADRB2(2), CFTR(4), GNAS(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 7871603 20 20 20 4 2 2 0 13 3 0 0.602 0.539 1.000 102 FOSBPATHWAY FOSB gene expression and drug abuse CDK5, FOSB, GRIA2, JUND, PPP1R1B 4 FOSB(1), GRIA2(3), PPP1R1B(1) 2194172 5 5 5 2 1 1 0 3 0 0 0.747 0.541 1.000 103 METHIONINE_METABOLISM AHCY, BHMT, CBS, CTH, DNMT1, DNMT2, DNMT3A, DNMT3B, MARS, MARS2, MAT1A, MAT2B, MTR 12 BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), MARS(2), MARS2(3) 10707151 18 18 18 2 2 2 5 6 3 0 0.114 0.543 1.000 104 HSA00363_BISPHENOL_A_DEGRADATION Genes involved in bisphenol A degradation AKR1B10, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HSD3B7, PON1, PON2, PON3, RDH11, RDH12, RDH13, RDH14 14 AKR1B10(2), DHRS2(1), PON3(2), RDH11(3) 5499382 8 8 8 1 1 0 3 4 0 0 0.363 0.544 1.000 105 BLYMPHOCYTEPATHWAY B cells express the major histocompatibility complex (class II MHC), immunoglobulins, adhesion proteins, and other factors on their cell surface. CD80, CR1, CR2, FCGR2B, HLA-DRA, HLA-DRB1, ICAM1, ITGAL, ITGB2, PTPRC, TNFRSF5 10 CR1(7), CR2(1), HLA-DRA(1), ITGAL(4), ITGB2(1), PTPRC(6) 9271803 20 19 20 3 2 1 1 12 4 0 0.339 0.549 1.000 106 FATTY_ACID_BIOSYNTHESIS_PATH_2 ACAA1, ACAA2, ACAT1, ACAT2, ECHS1, EHHADH, HADHA, HADHB, SDS 9 ECHS1(2), EHHADH(2), HADHA(1), HADHB(2) 5239709 7 7 7 0 1 3 2 1 0 0 0.0751 0.554 1.000 107 HSA00062_FATTY_ACID_ELONGATION_IN_MITOCHONDRIA Genes involved in fatty acid elongation in mitochondria ACAA2, ECHS1, HADH, HADHA, HADHB, HSD17B10, HSD17B4, MECR, PPT1, PPT2 10 ECHS1(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), MECR(1) 5191321 8 7 8 0 1 1 4 2 0 0 0.0635 0.560 1.000 108 CREMPATHWAY The transcription factor CREM activates a post-meiotic transcriptional cascade culminating in spermatogenesis. ADCY1, CREM, FHL5, FSHB, FSHR, GNAS, XPO1 7 ADCY1(1), CREM(1), FHL5(2), GNAS(4), XPO1(6) 5753041 14 14 14 3 2 1 3 7 1 0 0.521 0.560 1.000 109 TCYTOTOXICPATHWAY Cytotoxic T cells release perforin and granzyme to lyse foreign cell targets and express Fas ligand to promote Fas-induced apoptosis. CD2, CD28, CD3D, CD3E, CD3G, CD3Z, CD8A, ICAM1, ITGAL, ITGB2, PTPRC, THY1, TRA@, TRB@ 11 CD28(1), CD3E(2), CD3G(1), ITGAL(4), ITGB2(1), PTPRC(6) 6594819 15 13 15 3 2 2 2 8 1 0 0.356 0.566 1.000 110 HSA00430_TAURINE_AND_HYPOTAURINE_METABOLISM Genes involved in taurine and hypotaurine metabolism BAAT, CDO1, CSAD, GAD1, GAD2, GGT1, GGTL3, GGTL4 6 BAAT(1), CSAD(1), GAD2(1), GGT1(2) 3484980 5 5 5 1 0 1 2 1 1 0 0.469 0.566 1.000 111 INSULINPATHWAY Insulin regulates glucose levels via Ras-mediated transcriptional activation. CSNK2A1, ELK1, FOS, GRB2, HRAS, INS, INSR, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SLC2A4, SOS1, SRF 21 ELK1(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SLC2A4(1), SOS1(6), SRF(1) 15351307 40 38 37 7 3 14 5 16 2 0 0.0481 0.568 1.000 112 HSA00940_PHENYLPROPANOID_BIOSYNTHESIS Genes involved in phenylpropanoid biosynthesis EPX, GBA, GBA3, LPO, MPO, PRDX6, TPO 7 EPX(1), GBA(2), GBA3(2), MPO(4), TPO(3) 5150129 12 12 12 3 1 2 4 5 0 0 0.390 0.574 1.000 113 IL4PATHWAY IL-4 promotes Th2 cell differentiation via a heterodimeric receptor that activates Stat6/JAK and MAP kinase pathways. AKT1, GRB2, IL2RG, IL4, IL4R, IRS1, JAK1, JAK3, RPS6KB1, SHC1, STAT6 11 AKT1(2), GRB2(1), IL4(1), IL4R(2), IRS1(3), JAK1(4), JAK3(3), RPS6KB1(1), SHC1(2), STAT6(2) 8845567 21 21 21 4 3 3 2 9 4 0 0.271 0.585 1.000 114 NKCELLSPATHWAY Natural killer (NK) lymphocytes are inhibited by MHC and activated by surface glycoproteins on tumor or virus-infected cells, which undergo perforin-mediated lysis. B2M, HLA-A, IL18, ITGB1, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LAT, MAP2K1, MAPK3, PAK1, PIK3CA, PIK3R1, PTK2B, PTPN6, RAC1, SYK, VAV1 20 B2M(2), ITGB1(3), KLRC1(2), KLRC2(4), MAPK3(1), PAK1(1), PIK3CA(12), PIK3R1(2), PTK2B(2), PTPN6(3), RAC1(1), SYK(1), VAV1(2) 11559475 36 32 32 7 2 10 5 11 8 0 0.179 0.592 1.000 115 EPONFKBPATHWAY The cytokine erythropoietin (Epo) prevents stress-induced neuronal apoptosis by stimulating anti-apoptotic pathways through JAK2 kinase and NF-kB. ARNT, CDKN1A, EPO, EPOR, GRIN1, HIF1A, JAK2, NFKB1, NFKBIA, RELA, SOD2 11 ARNT(1), CDKN1A(1), GRIN1(2), HIF1A(3), JAK2(5), NFKB1(1), RELA(1) 7829958 14 13 14 2 0 4 1 6 3 0 0.238 0.592 1.000 116 METHIONINEPATHWAY Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine BCKDHB, BCKDK, CBS, CTH, MUT 5 BCKDK(1), CTH(1), MUT(2) 3013227 4 4 4 0 1 0 1 0 2 0 0.467 0.593 1.000 117 GPCRDB_CLASS_C_METABOTROPIC_GLUTAMATE_PHEROMONE CASR, GABBR1, GPCR5A, GPR51, GPRC5A, GPRC5B, GPRC5C, GPRC5D, GRM1, GRM2, GRM3, GRM4, GRM5, GRM7, GRM8 13 CASR(3), GABBR1(1), GPRC5A(1), GPRC5B(1), GPRC5C(1), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM7(1), GRM8(2) 11996305 25 25 25 4 4 5 1 13 2 0 0.125 0.596 1.000 118 LEPTINPATHWAY Leptin is a peptide secreted by adipose tissue that, in skeletal muscle, promotes fatty acid oxidation, decreases cells' lipid content, and promotes insulin sensitivity. ACACA, CPT1A, LEP, LEPR, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2 10 ACACA(4), CPT1A(1), LEP(1), LEPR(1), PRKAG1(1), PRKAG2(4) 9049850 12 12 12 1 0 3 3 3 3 0 0.0937 0.597 1.000 119 RANPATHWAY RanGEF (aka RCC1) and RanGFP regulate the GTP- or GDP-bound state of Ran, creating a Ran gradient across the nuclear membrane that is used in nuclear import. CHC1, RAN, RANBP1, RANBP2, RANGAP1 4 RAN(1), RANBP2(11) 5254489 12 9 12 2 1 5 2 4 0 0 0.249 0.598 1.000 120 HSA00260_GLYCINE_SERINE_AND_THREONINE_METABOLISM Genes involved in glycine, serine and threonine metabolism ABP1, AGXT, AGXT2, AKR1B10, ALAS1, ALAS2, AMT, AOC2, AOC3, BHMT, CBS, CHDH, CHKA, CHKB, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, GNMT, HSD3B7, MAOA, MAOB, PEMT, PHGDH, PIPOX, PISD, PSAT1, PSPH, RDH11, RDH12, RDH13, RDH14, SARDH, SARS, SARS2, SDS, SHMT1, SHMT2, TARS, TARS2 45 ABP1(5), AGXT(1), AGXT2(1), AKR1B10(2), ALAS1(4), ALAS2(3), AOC2(2), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), GNMT(2), MAOA(1), PHGDH(2), PIPOX(1), PISD(1), PSAT1(1), RDH11(3), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2), TARS2(3) 26493557 60 56 59 7 5 10 13 27 5 0 0.00239 0.600 1.000 121 IL5PATHWAY Pro-inflammatory IL-5 is secretes by activated T cells, eosinophils, and mast cells, and stimulates the proliferation and activation of eosinophils in bone marrow. CCL11, CCR3, CD4, HLA-DRA, HLA-DRB1, IL1B, IL4, IL5, IL5RA, IL6 10 CD4(2), HLA-DRA(1), IL4(1) 3130229 4 4 4 1 0 1 1 1 1 0 0.740 0.608 1.000 122 SIG_CD40PATHWAYMAP Genes related to CD40 signaling DUSP1, GORASP1, IKBKG, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PIK3CA, PIK3CD, PIK3R1, SYT1, TNFRSF5, TRAF2, TRAF3, TRAF5, TRAF6 32 MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3R1(2), SYT1(1), TRAF3(1), TRAF5(3), TRAF6(1) 20255215 36 34 33 3 4 9 3 16 4 0 0.00313 0.613 1.000 123 HSA00271_METHIONINE_METABOLISM Genes involved in methionine metabolism AHCY, AMD1, BHMT, CBS, CTH, DNMT1, DNMT3A, DNMT3B, KIAA0828, MARS, MARS2, MAT1A, MAT2B, MTAP, MTFMT, MTR, SRM, TAT 17 BHMT(1), CTH(1), DNMT1(6), DNMT3A(5), MARS(2), MARS2(3), MTAP(2) 12789093 20 20 20 2 2 2 6 7 3 0 0.0802 0.623 1.000 124 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes AKT1, AKT2, AKT3, BAD, BCL2, GRB2, GSK3A, GSK3B, IL4R, IRS1, IRS2, JAK1, JAK3, MAP4K1, MAPK1, MAPK3, PDK1, PIK3CA, PIK3CD, PIK3R1, PPP1R13B, RAF1, SHC1, SOCS1, SOS1, SOS2, STAT6 25 AKT1(2), AKT2(3), AKT3(2), GRB2(1), GSK3A(2), IL4R(2), IRS1(3), JAK1(4), JAK3(3), MAP4K1(1), MAPK3(1), PDK1(1), PIK3CA(12), PIK3R1(2), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), STAT6(2) 21627513 53 50 50 8 4 13 6 23 7 0 0.0252 0.623 1.000 125 HSA00900_TERPENOID_BIOSYNTHESIS Genes involved in terpenoid biosynthesis FDFT1, FDPS, GGPS1, IDI1, IDI2, SQLE 6 FDPS(1), IDI1(1), IDI2(2) 2721446 4 4 4 1 0 0 0 3 1 0 0.831 0.625 1.000 126 HSA00730_THIAMINE_METABOLISM Genes involved in thiamine metabolism LHPP, MTMR1, MTMR2, MTMR6, NFS1, PHPT1, THTPA, TPK1 8 MTMR1(1), MTMR2(1), NFS1(2), TPK1(1) 4001753 5 5 5 0 2 0 0 3 0 0 0.310 0.628 1.000 127 1_AND_2_METHYLNAPHTHALENE_DEGRADATION ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1 7 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2) 3513076 6 6 5 2 1 0 0 3 2 0 0.896 0.638 1.000 128 MRPPATHWAY Cancer cells resistant to numerous drugs are called multidrug-resistant (MDR) and express ATP-binding cassette transporter proteins that pump the drugs out of cells. ABCB1, ABCB11, ABCB4, ABCC1, ABCC3, GSTP1 6 ABCB1(4), ABCB11(1), ABCB4(1), ABCC1(2), ABCC3(7) 9082866 15 15 15 2 1 1 4 7 2 0 0.227 0.639 1.000 129 P53PATHWAY p53 induces cell cycle arrest or apoptosis under conditions of DNA damage. APAF1, ATM, BAX, BCL2, CCND1, CCNE1, CDK2, CDK4, CDKN1A, E2F1, GADD45A, MDM2, PCNA, RB1, TIMP3, TP53 16 ATM(15), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), PCNA(3), RB1(1), TP53(10) 11322059 36 27 36 6 3 5 6 12 10 0 0.162 0.640 1.000 130 HSA00760_NICOTINATE_AND_NICOTINAMIDE_METABOLISM Genes involved in nicotinate and nicotinamide metabolism AOX1, BST1, C9orf95, CD38, ENPP1, ENPP3, NADK, NADSYN1, NMNAT1, NMNAT2, NMNAT3, NNMT, NNT, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT12, PBEF1, QPRT 22 AOX1(7), CD38(1), ENPP3(1), NMNAT2(1), NMNAT3(2), NNMT(1), NNT(6), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT12(1), QPRT(1) 13268381 26 25 26 4 0 3 4 14 5 0 0.234 0.641 1.000 131 BENZOATE_DEGRADATION_VIA_COA_LIGATION ACAT1, ACAT2, ACYP1, ACYP2, ECHS1, EHHADH, GCDH, HADHA, SDHB, SDS 10 ECHS1(2), EHHADH(2), HADHA(1), SDHB(1) 4874713 6 6 6 0 1 2 2 1 0 0 0.110 0.643 1.000 132 IL1RPATHWAY The cytokine IL-1 stimulates its primary receptor, IL-1R1, which induces transcription of inflammation-related genes such as interferons. CHUK, IFNA1, IFNB1, IKBKB, IL1A, IL1B, IL1R1, IL1RAP, IL1RN, IL6, IRAK1, IRAK2, IRAK3, JUN, MAP2K3, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, RELA, SITPEC, TGFB1, TGFB2, TGFB3, TNF, TOLLIP, TRAF6 31 CHUK(1), IFNA1(2), IFNB1(2), IL1R1(1), IL1RAP(4), IRAK1(3), IRAK3(2), JUN(2), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFB2(2), TGFB3(1), TRAF6(1) 18348027 34 33 33 4 4 8 0 15 7 0 0.0577 0.656 1.000 133 HSA00272_CYSTEINE_METABOLISM Genes involved in cysteine metabolism CARS, CARS2, CDO1, CTH, GOT1, GOT2, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, MPST, SDS, SULT1B1, SULT1C2, SULT1C4, SULT4A1 17 CARS(4), CARS2(2), CTH(1), GOT1(2), GOT2(2), LDHAL6B(1), LDHB(1), LDHC(1), MPST(2), SULT1B1(1), SULT4A1(1) 7728778 18 18 18 4 1 0 2 9 6 0 0.707 0.656 1.000 134 HSA00785_LIPOIC_ACID_METABOLISM Genes involved in lipoic acid metabolism LIAS, LIPT1, LOC387787 2 LIAS(1) 953417 1 1 1 1 0 0 0 1 0 0 0.943 0.657 1.000 135 FREEPATHWAY Neutrophils release superoxide to induce lysis in invading bacteria; in neighboring endothelial cells, superoxide dismutase scavenges radicals but produces pro-apoptotic peroxides. GPX1, GSR, GSS, IL8, NFKB1, NOX1, RELA, SOD1, TNF, XDH 10 GSR(1), GSS(1), NFKB1(1), NOX1(2), RELA(1), XDH(2) 6077631 8 8 8 1 0 2 2 4 0 0 0.251 0.657 1.000 136 PEPIPATHWAY Proepithelin (PEPI) induces epithelial cells to secrete IL-8, which promotes elastase secretion by neutrophils. ELA1, ELA2, ELA2A, ELA2B, ELA3B, GRN, IL8, SLPI 3 GRN(1) 1038575 1 1 1 0 0 0 0 1 0 0 0.838 0.660 1.000 137 HYPERTROPHY_MODEL ADAM10, ANKRD1, ATF3, CYR61, DUSP14, EIF4E, EIF4EBP1, GDF8, HBEGF, IFNG, IFRD1, IL18, IL1A, IL1R1, JUND, MYOG, NR4A3, TCF8, VEGF, WDR1 16 ADAM10(4), ANKRD1(1), EIF4E(1), IFRD1(1), IL1R1(1), NR4A3(2), WDR1(1) 6617914 11 11 11 2 0 3 2 3 3 0 0.443 0.662 1.000 138 PROTEASOMEPATHWAY Ubiquitinated proteins are targeted for proteolytic degradation by the proteasome, where they are unfolded and degraded to small peptides in an ATP-dependent process. PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC3, PSMD14, RPN1, RPN2, UBE1, UBE2A, UBE3A 20 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), RPN1(2), RPN2(1), UBE2A(2), UBE3A(1) 8192549 16 16 16 3 0 1 2 8 5 0 0.536 0.668 1.000 139 ERYTHPATHWAY Erythropoietin selectively stimulates erythrocyte differentiation from CFU-GEMM cells in bone marrow. CCL3, CSF2, CSF3, EPO, FLT3, IGF1, IL11, IL1A, IL3, IL6, IL9, KITLG, TGFB1, TGFB2, TGFB3 15 CCL3(1), FLT3(2), IL3(1), KITLG(2), TGFB2(2), TGFB3(1) 5170275 9 9 9 2 0 1 1 6 1 0 0.663 0.674 1.000 140 RABPATHWAY Rab family GTPases regulate vesicle transport, endocytosis and exocytosis, and vesicle docking via interactions with the rabphilins. ACTA1, MEL, RAB11A, RAB1A, RAB2, RAB27A, RAB3A, RAB4A, RAB5A, RAB6A, RAB7, RAB9A 9 RAB1A(1), RAB3A(1), RAB5A(1) 2650758 3 3 3 0 1 0 1 0 1 0 0.378 0.680 1.000 141 D4GDIPATHWAY D4-GDI inhibits the pro-apoptotic Rho GTPases and is cleaved by caspase-3. ADPRT, APAF1, ARHGAP5, ARHGDIB, CASP1, CASP10, CASP3, CASP8, CASP9, CYCS, GZMB, JUN, PRF1 12 ARHGAP5(4), ARHGDIB(1), CASP1(1), CASP10(3), JUN(2), PRF1(1) 7740063 12 12 12 2 0 2 0 7 3 0 0.562 0.683 1.000 142 SPRYPATHWAY Four members of the Sprouty protein family block proliferative EGF signals by binding Grb-2, preventing Ras and MAP kinase activation. CBL, EGF, EGFR, GRB2, HRAS, MAP2K1, MAPK1, MAPK3, PTPRB, RAF1, RASA1, SHC1, SOS1, SPRY1, SPRY2, SPRY3, SPRY4, SRC 18 CBL(1), EGF(4), EGFR(7), GRB2(1), HRAS(1), MAPK3(1), PTPRB(3), RASA1(3), SHC1(2), SOS1(6), SPRY2(2), SPRY4(2), SRC(2) 15443263 35 32 34 5 4 11 5 10 5 0 0.0491 0.684 1.000 143 TH1TH2PATHWAY Helper T subtype Th1 produces pro-inflammatory cytokines that stimulate phagocytosis, while Th2 cells promote antibody production and activate eosinophils. CD28, CD86, HLA-DRA, HLA-DRB1, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, IL2, IL2RA, IL4, IL4R, TNFRSF5, TNFSF5 17 CD28(1), CD86(1), HLA-DRA(1), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL2RA(2), IL4(1), IL4R(2) 7709460 15 14 15 3 3 1 1 8 2 0 0.418 0.684 1.000 144 HSA00642_ETHYLBENZENE_DEGRADATION Genes involved in ethylbenzene degradation ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 12 DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1) 10184606 15 14 15 1 1 1 3 8 2 0 0.131 0.688 1.000 145 EOSINOPHILSPATHWAY Recruitment of eosinophils in the inflammatory response observed in asthma occurs via the chemoattractant eotaxin binding to the CCR3 receptor. CCL11, CCL5, CCR3, CSF2, HLA-DRA, HLA-DRB1, IL3, IL5 8 HLA-DRA(1), IL3(1) 1672187 2 2 2 0 0 0 0 1 1 0 0.825 0.690 1.000 146 HSA00400_PHENYLALANINE_TYROSINE_AND_TRYPTOPHAN_BIOSYNTHESIS Genes involved in phenylalanine, tyrosine and tryptophan biosynthesis FARS2, FARSA, FARSB, GOT1, GOT2, PAH, TAT, YARS, YARS2 9 FARSA(1), GOT1(2), GOT2(2), PAH(3), YARS(1) 5406809 9 9 9 2 0 0 3 3 3 0 0.568 0.696 1.000 147 STEROID_BIOSYNTHESIS CYP17A1, F13B, HSD17B1, HSD17B2, HSD17B3, HSD17B4, HSD17B7, HSD3B1, HSD3B2 9 CYP17A1(1), F13B(2), HSD17B1(1), HSD17B4(1), HSD3B1(1) 5022413 6 6 6 1 1 0 3 2 0 0 0.435 0.698 1.000 148 ALTERNATIVEPATHWAY The alternative complement pathway is an antibody-independent mechanism of immune activation that results in cell lysis via the membrane attack complex. BF, C3, C5, C6, C7, C8A, C9, DF, PFC 6 C3(6), C5(4), C7(2) 7970191 12 12 12 2 1 2 1 6 2 0 0.330 0.700 1.000 149 SA_G1_AND_S_PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. ARF1, ARF3, CCND1, CDK2, CDK4, CDKN1A, CDKN1B, CDKN2A, CFL1, E2F1, E2F2, MDM2, NXT1, PRB1, TP53 15 ARF1(1), ARF3(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CFL1(1), E2F1(1), PRB1(2), TP53(10) 5102483 23 20 23 7 2 2 4 8 7 0 0.632 0.700 1.000 150 ERK5PATHWAY Signaling between a tissue and its innervating axon stimulates retrograde transport via Trk receptors, which activate Erk5, which induces transcription of anti-apoptotic factors. AKT1, CREB1, GRB2, HRAS, MAPK1, MAPK3, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, NTRK1, PIK3CA, PIK3R1, PLCG1, RPS6KA1, SHC1 17 AKT1(2), GRB2(1), HRAS(1), MAPK3(1), MEF2A(1), MEF2D(1), NTRK1(4), PIK3CA(12), PIK3R1(2), RPS6KA1(2), SHC1(2) 11780934 29 29 26 5 4 8 3 11 3 0 0.0992 0.701 1.000 151 EGFPATHWAY The epidermal growth factor (EGF) peptide stimulates the EGF receptor to promote cell proliferation via the MAP kinase and Ras pathways. CSNK2A1, EGF, EGFR, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 EGF(4), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(4), MAPK3(1), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1) 23032826 56 54 52 9 4 12 6 24 10 0 0.0579 0.705 1.000 152 ARAPPATHWAY ADP-ribosylation factors (ARFs), members of the Ras superfamily, regulate eukaryotic vesicular trafficking and activate phospholipase D's. ARF1, ARFGAP1, ARFGAP3, ARFGEF2, BIG1, CENTD1, CENTD2, CLTA, CLTB, COP, COPA, DDEF1, DDEF2, GBF1, GPLD1, KDELR1, KDELR2, KDELR3, PSCD1, PSCD2, PSCD3, PSCD4 12 ARF1(1), ARFGEF2(5), COPA(4), GBF1(6), GPLD1(1), KDELR2(2), KDELR3(2) 10108847 21 20 21 4 0 1 4 11 4 1 0.455 0.705 1.000 153 HSA00460_CYANOAMINO_ACID_METABOLISM Genes involved in cyanoamino acid metabolism ASRGL1, GBA, GBA3, GGT1, GGTL3, GGTL4, SHMT1, SHMT2 6 GBA(2), GBA3(2), GGT1(2), SHMT1(2), SHMT2(3) 3431600 11 11 11 4 0 1 3 4 3 0 0.757 0.706 1.000 154 PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS AKR1B1, DCXR, GUSB, RPE, RPE, LOC440001, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 18 AKR1B1(2), GUSB(6), RPE(1), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 10943629 21 17 19 3 1 5 4 5 6 0 0.171 0.706 1.000 155 HSA00602_GLYCOSPHINGOLIPID_BIOSYNTHESIS_NEO_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - neo-lactoseries ABO, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALT1, B4GALT2, B4GALT3, B4GALT4, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GCNT2, ST3GAL6, ST8SIA1 21 ABO(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), FUT1(1), FUT6(1), GCNT2(4), ST3GAL6(1), ST8SIA1(2) 9346872 17 16 17 3 2 3 3 5 4 0 0.291 0.713 1.000 156 AHSPPATHWAY Alpha-hemoglobin stabilizing protein (AHSP) prevents precitipation of hemoglobin alpha-subunits. ALAD, ALAS1, ALAS2, CPO, ERAF, FECH, GATA1, HBA1, HBA2, HBB, HMBS, UROD, UROS 12 ALAS1(4), ALAS2(3), CPO(1), FECH(2), GATA1(1), HBB(3) 5009016 14 14 12 4 0 1 2 9 2 0 0.642 0.716 1.000 157 ACHPATHWAY Nicotinic acetylcholine receptors are ligand-gated ion channels that primarily mediate neuromuscular signaling and may inhibit neuronal apoptosis via the AKT pathway. AKT1, BAD, CHRNB1, CHRNG, FOXO3A, MUSK, PIK3CA, PIK3R1, PTK2, PTK2B, RAPSN, SRC, TERT, TNFSF6, YWHAH 13 AKT1(2), CHRNB1(1), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(2), SRC(2), TERT(4) 10201486 26 26 23 5 2 12 2 8 2 0 0.115 0.726 1.000 158 TUBBYPATHWAY Tubby is activated by phospholipase C activity and hydrolysis of PIP2, after which it enters the nucleus and regulates transcription. CHRM1, GNAQ, GNB1, GNGT1, HTR2C, PLCB1, TUB 7 GNB1(2), HTR2C(1), PLCB1(1), TUB(2) 4389203 6 6 6 1 0 0 0 5 1 0 0.622 0.730 1.000 159 CIRCADIANPATHWAY A heterodimer composed of Bmal1 and Clock acts as a transcription factor for proteins that regulate circadian rhythms, such as Per and Cry. ARNTL, CLOCK, CRY1, CRY2, CSNK1E, PER1 6 ARNTL(1), CLOCK(1), PER1(4) 5237843 6 6 6 1 0 0 2 3 0 1 0.422 0.736 1.000 160 SIG_CHEMOTAXIS Genes related to chemotaxis ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGAP1, ARHGAP4, ARHGEF11, BTK, CDC42, CFL1, CFL2, GDI1, GDI2, INPPL1, ITPR1, ITPR2, ITPR3, LIMK1, MYLK, MYLK2, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDK1, PIK3CA, PIK3CD, PIK3CG, PIK3R1, PITX2, PPP1R13B, PTEN, RACGAP1, RHO, ROCK1, ROCK2, RPS4X, SAG, WASF1, WASL 44 ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP1(1), ARHGEF11(3), BTK(1), CDC42(1), CFL1(1), INPPL1(2), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CA(12), PIK3CG(3), PIK3R1(2), PITX2(1), PPP1R13B(3), PTEN(20), RACGAP1(1), RHO(1), ROCK1(4), ROCK2(3), SAG(2), WASL(6) 43511786 102 85 99 11 4 24 10 37 26 1 0.000101 0.738 1.000 161 SA_FAS_SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding. BCL2, CASP3, CASP8, CFL1, CFLAR, P11, PDE6D, TNFRSF6, TNFSF6 6 CFL1(1), CFLAR(1) 2379318 2 2 2 1 0 0 1 0 1 0 0.893 0.747 1.000 162 NDKDYNAMINPATHWAY Endocytotic role of NDK, Phosphins and Dynamin AMPH, AP2A1, AP2M1, BIN1, CALM1, CALM2, CALM3, DNM1, EPN1, EPS15, NME1, NME2, PICALM, PPP3CA, PPP3CB, PPP3CC, SYNJ1, SYNJ2, SYT1 19 AMPH(3), AP2A1(1), BIN1(3), CALM2(1), DNM1(1), EPN1(1), EPS15(2), PICALM(1), PPP3CA(1), PPP3CC(1), SYNJ1(4), SYNJ2(5), SYT1(1) 13786023 25 25 23 4 1 5 1 15 3 0 0.223 0.755 1.000 163 HSA00643_STYRENE_DEGRADATION Genes involved in styrene degradation FAH, GSTZ1, HGD 3 HGD(1) 1401723 1 1 1 1 0 0 1 0 0 0 0.902 0.769 1.000 164 GLUCOCORTICOID_MINERALOCORTICOID_METABOLISM CPN2, CYP11A1, CYP11B2, CYP17A1, HSD11B1, HSD11B2, HSD3B1, HSD3B2 8 CYP11A1(1), CYP11B2(2), CYP17A1(1), HSD3B1(1) 4223555 5 5 5 0 0 0 1 4 0 0 0.364 0.770 1.000 165 SA_G2_AND_M_PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. CDC2, CDC25A, CDC25B, CDK7, CDKN1A, CHEK1, NEK1, WEE1 7 CDC25A(1), CDKN1A(1), NEK1(2), WEE1(1) 4601050 5 5 5 1 0 1 0 3 1 0 0.707 0.784 1.000 166 NKTPATHWAY T cell differentiation into Th1 and Th2 cells occurs by differential chemokine receptor expression, which mediates tissue localization and immune response. CCL3, CCL4, CCR1, CCR2, CCR3, CCR4, CCR5, CCR7, CD28, CD4, CSF2, CXCR3, CXCR4, IFNG, IFNGR1, IFNGR2, IL12A, IL12B, IL12RB1, IL12RB2, IL18R1, IL2, IL4, IL4R, IL5, TGFB1, TGFB2, TGFB3, TNFSF5 28 CCL3(1), CD28(1), CD4(2), CXCR4(1), IFNGR1(2), IFNGR2(1), IL12RB1(1), IL12RB2(2), IL18R1(1), IL4(1), IL4R(2), TGFB2(2), TGFB3(1) 12475000 18 17 18 2 3 2 2 10 1 0 0.0994 0.788 1.000 167 HSA01040_POLYUNSATURATED_FATTY_ACID_BIOSYNTHESIS Genes involved in polyunsaturated fatty acid biosynthesis ACAA1, ACOX1, ACOX3, ELOVL2, ELOVL5, ELOVL6, FADS1, FADS2, FASN, GPSN2, HADHA, HSD17B12, PECR, SCD 13 ACOX1(1), ACOX3(2), ELOVL2(1), ELOVL5(1), FADS2(2), FASN(3), HADHA(1), PECR(1) 8764661 12 11 12 2 3 1 3 5 0 0 0.205 0.789 1.000 168 HSA00960_ALKALOID_BIOSYNTHESIS_II Genes involved in alkaloid biosynthesis II AADAC, ABP1, AOC2, AOC3, ARD1A, CES1, CES7, DDHD1, ESCO1, ESCO2, LIPA, LYCAT, MYST3, MYST4, NAT5, NAT6, PLA1A, PNPLA3, PPME1, PRDX6, SH3GLB1 18 AADAC(1), ABP1(5), AOC2(2), AOC3(1), CES1(2), DDHD1(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1) 15496342 26 23 26 2 1 3 4 15 3 0 0.0494 0.794 1.000 169 GLYCOLYSISPATHWAY Glycolysis is an evolutionarily conserved pathway by which one glucose molecule is converted to two pyruvate molecules for a gain of 2 ATP. ALDOB, ENO1, GAPD, GPI, HK1, PFKL, PGAM1, PGK1, PKLR, TPI1 9 ALDOB(3), ENO1(2), HK1(4), PFKL(1), PGAM1(1), PGK1(2), TPI1(1) 5618781 14 12 14 4 2 2 2 4 4 0 0.551 0.799 1.000 170 HSA00534_HEPARAN_SULFATE_BIOSYNTHESIS Genes involved in heparan sulfate biosynthesis EXT1, EXT2, EXTL1, EXTL2, EXTL3, GLCE, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, NDST1, NDST2, NDST3, NDST4 19 EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), GLCE(2), HS2ST1(1), HS3ST5(1), NDST1(2), NDST2(2), NDST4(3) 12515265 16 16 16 1 2 3 5 6 0 0 0.0312 0.800 1.000 171 TGFBPATHWAY The TGF-beta receptor responds to ligand binding by activating the SMAD family of transcriptional regulations, commonly blocking cell growth. APC, CDH1, CREBBP, EP300, MADH2, MADH3, MADH4, MADH7, MADHIP, MAP2K1, MAP3K7, MAP3K7IP1, MAPK3, SKIL, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2 13 APC(6), CDH1(2), CREBBP(4), EP300(6), MAP3K7(1), MAPK3(1), SKIL(1), TGFB2(2), TGFB3(1), TGFBR2(1) 15938463 25 25 25 3 1 3 7 13 1 0 0.0575 0.800 1.000 172 TSP1PATHWAY Thrombospondin-1 (TSP-1) inhibits angiogenesis by inducing caspase-dependent apoptosis in microvascular endothelial cells. CASP3, CD36, FOS, FYN, JUN, MAPK14, THBS1 7 FYN(1), JUN(2), MAPK14(1), THBS1(6) 4457452 10 10 10 3 0 0 2 7 1 0 0.790 0.809 1.000 173 PDGFPATHWAY Platelet-derived growth factor (PDGF) receptor is phosphorylated on ligand binding and promotes cell proliferation. CSNK2A1, ELK1, FOS, GRB2, HRAS, JAK1, JUN, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, SRF, STAT1, STAT3, STAT5A 26 ELK1(1), GRB2(1), HRAS(1), JAK1(4), JUN(2), MAP3K1(4), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), SRF(1), STAT1(4), STAT3(1) 21462996 52 50 49 9 3 11 4 25 9 0 0.0849 0.810 1.000 174 REDUCTIVE_CARBOXYLATE_CYCLE_CO2_FIXATION ACO1, ACO2, FH, IDH1, IDH2, MDH1, MDH2, SDHB, SUCLA2 9 ACO1(4), IDH1(2), MDH1(1), SDHB(1) 5550156 8 8 8 2 1 0 1 5 1 0 0.570 0.811 1.000 175 VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS BCAT1, IARS, LARS, LARS2, PDHA1, PDHA2, PDHB 7 BCAT1(1), IARS(4), LARS(1), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1) 6247357 10 9 10 2 0 2 1 5 2 0 0.456 0.813 1.000 176 TERPENOID_BIOSYNTHESIS FDFT1, FDPS, FDPS, LOC402397, IDI1, SQLE 4 FDPS(1), IDI1(1) 2048015 2 2 2 1 0 0 0 1 1 0 0.951 0.821 1.000 177 HSA00450_SELENOAMINO_ACID_METABOLISM Genes involved in selenoamino acid metabolism AHCY, CARM1, CBS, CTH, GGT1, GGTL3, GGTL4, HEMK1, KIAA0828, LCMT1, LCMT2, MARS, MARS2, MAT1A, MAT2B, METTL2B, METTL6, PAPSS1, PAPSS2, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SCLY, SEPHS1, SEPHS2, WBSCR22 26 CTH(1), GGT1(2), LCMT1(1), LCMT2(3), MARS(2), MARS2(3), PAPSS1(3), PAPSS2(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SEPHS1(1), SEPHS2(2) 15122744 26 25 26 3 3 2 7 10 4 0 0.0713 0.822 1.000 178 N_GLYCAN_DEGRADATION AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 13 AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2C1(5), NEU1(1) 9707266 17 16 17 3 2 2 2 10 1 0 0.305 0.828 1.000 179 EXTRINSICPATHWAY The extrinsic prothrombin activation pathway requires the release of thromboplastin from damaged tissues to activate the blood clotting cascade. F10, F2, F2R, F3, F5, F7, FGA, FGB, FGG, PROC, PROS1, SERPINC1, TFPI 13 F2(3), F5(4), F7(1), FGA(1), FGG(1), PROC(4), PROS1(4), TFPI(1) 10095035 19 19 19 4 0 2 1 11 5 0 0.573 0.829 1.000 180 HSA04740_OLFACTORY_TRANSDUCTION Genes involved in olfactory transduction ADCY3, ADRBK2, ARRB2, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CLCA1, CLCA2, CLCA4, CNGA3, CNGA4, CNGB1, GNAL, GUCA1A, GUCA1B, GUCA1C, PDC, PDE1C, PRKACA, PRKACB, PRKACG, PRKG1, PRKG2, PRKX, PRKY 30 ADCY3(3), ADRBK2(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CLCA4(2), CNGA3(3), CNGA4(2), CNGB1(2), GUCA1B(1), PDC(1), PDE1C(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKG1(2), PRKG2(2) 19142752 33 31 33 4 4 5 3 18 3 0 0.0531 0.832 1.000 181 CDC25PATHWAY The protein phosphatase Cdc25 is phosphorylated by Chk1 and activates Cdc2 to stimulate eukaryotic cells into M phase. ATM, CDC2, CDC25A, CDC25B, CDC25C, CHEK1, MYT1, WEE1, YWHAH 8 ATM(15), CDC25A(1), CDC25C(2), MYT1(2), WEE1(1) 8602771 21 18 21 4 0 2 3 10 6 0 0.425 0.840 1.000 182 SKP2E2FPATHWAY E2F-1, a transcription factor that promotes the G1/S transition, is repressed by Rb and activated by cdk2/cyclin E. CCNA1, CCNE1, CDC34, CDK2, CUL1, E2F1, RB1, SKP1A, SKP2, TFDP1 9 CCNA1(3), CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1) 5427994 13 12 13 4 1 3 2 3 4 0 0.602 0.842 1.000 183 HSA03020_RNA_POLYMERASE Genes involved in RNA polymerase POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, ZNRD1 23 POLR1A(2), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(2), POLR3G(1), POLR3H(1), POLR3K(1) 14511885 28 26 27 4 0 5 3 15 5 0 0.112 0.844 1.000 184 CHOLESTEROL_BIOSYNTHESIS C10orf110, CYP51A1, DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, HMGCS1, IDI1, LSS, MVD, MVK, NSDHL, PMVK, SC4MOL, SC5DL, SQLE 15 DHCR7(2), FDPS(1), HMGCS1(1), IDI1(1), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1) 8180078 10 10 10 1 0 0 1 7 2 0 0.447 0.850 1.000 185 GPCRDB_CLASS_A_RHODOPSIN_LIKE2 CYSLTR1, CYSLTR2, GPR109B, GPR161, GPR171, GPR18, GPR34, GPR39, GPR41, GPR42, GPR45, GPR65, GPR68, GPR75, GPR81, LYPDC1 13 CYSLTR1(1), GPR171(1), GPR39(1), GPR45(3), GPR65(1), GPR75(1) 6086980 8 8 8 2 1 1 0 4 2 0 0.304 0.851 1.000 186 PROTEASOME PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB10, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMB8, PSMB9 17 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1) 5188358 10 10 10 3 0 1 1 5 3 0 0.807 0.852 1.000 187 TALL1PATHWAY APRIL and BAFF bind to BCMA and TACI receptors on B cell surfaces, promoting immunoglobulin production and cell proliferation. CHUK, MAP3K14, MAPK14, MAPK8, NFKB1, RELA, TNFRSF13B, TNFRSF13C, TNFRSF17, TNFSF13, TNFSF13B, TRAF2, TRAF3, TRAF5, TRAF6 15 CHUK(1), MAP3K14(1), MAPK14(1), NFKB1(1), RELA(1), TNFRSF13B(1), TNFRSF17(1), TRAF3(1), TRAF5(3), TRAF6(1) 9068511 12 12 12 2 0 3 0 6 3 0 0.500 0.853 1.000 188 RNA_POLYMERASE POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT 14 POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1) 8092237 15 14 15 3 0 4 3 4 4 0 0.252 0.853 1.000 189 MTA3PATHWAY The estrogen receptor regulates proliferation in mammary epithelia via MTA3 activation; loss of either protein is implicated in breast cancer. ALDOA, CTSD, ESR1, GAPD, GREB1, HSPB1, HSPB2, MTA1, MTA3, PDZK1, TUBA1, TUBA2, TUBA3, TUBA4, TUBA6, TUBA8 10 ALDOA(2), GREB1(10), HSPB2(1), MTA1(1), MTA3(1) 6525181 15 14 14 4 0 1 2 11 1 0 0.654 0.856 1.000 190 HSA00902_MONOTERPENOID_BIOSYNTHESIS Genes involved in monoterpenoid biosynthesis CYP2C19, CYP2C9 2 CYP2C19(1) 1256994 1 1 1 1 0 0 0 1 0 0 0.940 0.857 1.000 191 HSA00603_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GLOBOSERIES Genes involved in glycosphingolipid biosynthesis - globoseries A4GALT, B3GALNT1, B3GALT5, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, ST3GAL1, ST3GAL2, ST8SIA1 14 FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2) 6518339 9 9 9 2 2 1 1 5 0 0 0.414 0.857 1.000 192 BIOSYNTHESIS_OF_STEROIDS DHCR7, FDFT1, FDPS, FDPS, LOC402397, HMGCR, IDI1, LSS, MVD, MVK, NQO1, NQO2, PMVK, SC5DL, SQLE, VKORC1 14 DHCR7(2), FDPS(1), IDI1(1), LSS(2), PMVK(1), SC5DL(1) 6858053 8 8 8 1 0 0 1 6 1 0 0.517 0.857 1.000 193 ST_IL_13_PATHWAY Like IL-4, IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3) 6430629 15 15 15 4 1 0 2 7 5 0 0.754 0.857 1.000 194 ST_INTERLEUKIN_13_PATHWAY IL-13 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. IL13, IL13RA1, IL13RA2, IL4R, JAK1, JAK2, TYK2 7 IL13RA1(1), IL4R(2), JAK1(4), JAK2(5), TYK2(3) 6430629 15 15 15 4 1 0 2 7 5 0 0.754 0.857 1.000 195 HSA00632_BENZOATE_DEGRADATION_VIA_COA_LIGATION Genes involved in benzoate degradation via CoA ligation ACAT1, ACAT2, ACOT11, ACYP1, ACYP2, ARD1A, CARKL, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, FN3K, GCDH, HADHA, ITGB1BP3, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 24 DHRS2(1), ECHS1(2), EHHADH(2), ESCO1(2), ESCO2(1), FN3K(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1) 15997725 22 21 22 2 2 3 4 9 4 0 0.0835 0.861 1.000 196 MITRPATHWAY The MyoD/MEF2 transcription factors induce muscle cell differentiation and are repressed by the transcriptional repressor MITR. CAMK1, CAMK1G, HDAC9, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, YWHAH 9 CAMK1(1), HDAC9(2), MEF2A(1), MEF2D(1) 5073214 5 5 5 0 1 0 0 2 2 0 0.462 0.867 1.000 197 HSA00232_CAFFEINE_METABOLISM Genes involved in caffeine metabolism CYP1A2, CYP2A13, CYP2A6, CYP2A7, NAT1, NAT2, XDH 7 CYP1A2(3), CYP2A13(2), NAT1(1), NAT2(2), XDH(2) 4930345 10 10 10 3 1 1 2 5 1 0 0.592 0.868 1.000 198 RAC1PATHWAY Rac-1 is a Rho family G protein that stimulates formation of actin-dependent structures such as filopodia and lamellopodia. ARFIP2, CDK5, CDK5R1, CFL1, CHN1, LIMK1, MAP3K1, MYL2, MYLK, NCF2, PAK1, PDGFRA, PIK3CA, PIK3R1, PLD1, PPP1R12B, RAC1, RALBP1, RPS6KB1, TRIO, VAV1, WASF1 22 ARFIP2(1), CFL1(1), CHN1(2), MAP3K1(4), MYL2(1), MYLK(4), NCF2(1), PAK1(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLD1(2), RAC1(1), RALBP1(1), RPS6KB1(1), TRIO(2), VAV1(2) 21681433 45 40 42 6 1 7 4 22 11 0 0.0675 0.871 1.000 199 HSA00830_RETINOL_METABOLISM Genes involved in retinol metabolism ALDH1A1, ALDH1A2, BCMO1, RDH5 4 ALDH1A1(1), ALDH1A2(1), RDH5(2) 2390471 4 4 4 2 0 0 2 1 1 0 0.861 0.874 1.000 200 RACCYCDPATHWAY Ras, Rac, and Rho coordinate to induce cyclin D1 expression and activate cdk2 to promote the G1/S transition. AKT1, ARHA, CCND1, CCNE1, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, E2F1, HRAS, MAPK1, MAPK3, NFKB1, NFKBIA, PAK1, PIK3CA, PIK3R1, RAC1, RAF1, RB1, RELA, TFDP1 22 AKT1(2), CCNE1(2), CDK2(2), CDK4(1), CDKN1A(1), E2F1(1), HRAS(1), MAPK3(1), NFKB1(1), PAK1(1), PIK3CA(12), PIK3R1(2), RAC1(1), RB1(1), RELA(1) 12535134 30 29 27 6 2 10 3 11 4 0 0.165 0.874 1.000 201 DNA_POLYMERASE POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLS 7 POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5) 10216827 17 17 17 3 2 0 0 11 4 0 0.428 0.875 1.000 202 P38MAPKPATHWAY The Rho family GTPases activate the p38 MAPKs under environmental stress or in the presence of pro-inflammatory cytokines. ATF2, CDC42, CREB1, DAXX, DDIT3, ELK1, GRB2, HMGN1, HRAS, HSPB1, HSPB2, MAP2K4, MAP2K6, MAP3K1, MAP3K5, MAP3K7, MAP3K9, MAPK14, MAPKAPK2, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MYC, PDZGEF1, PLA2G4A, RAC1, RIPK1, RPS6KA5, SHC1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 39 ATF2(1), CDC42(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), HSPB2(1), MAP2K6(1), MAP3K1(4), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK14(1), MAPKAPK5(1), MAX(3), MEF2A(1), MEF2D(1), MKNK1(1), MYC(1), PLA2G4A(1), RAC1(1), RIPK1(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1) 22702665 44 42 44 6 4 3 2 27 8 0 0.103 0.880 1.000 203 BLOOD_GROUP_GLYCOLIPID_BIOSYNTHESIS_LACTOSERIES ABO, FUT1, FUT2, FUT3, FUT5, FUT6, SIAT6, ST3GAL3 7 ABO(1), FUT1(1), FUT6(1), ST3GAL3(1) 2904083 4 4 4 2 2 0 0 0 2 0 0.905 0.881 1.000 204 HSA00626_NAPHTHALENE_AND_ANTHRACENE_DEGRADATION Genes involved in naphthalene and anthracene degradation CARM1, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 18 DHRS2(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1) 9112464 11 10 11 1 1 2 2 5 1 0 0.212 0.885 1.000 205 SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES ACAT1, ACAT2, BDH, HMGCL, OXCT1 4 OXCT1(1) 2114168 1 1 1 1 0 0 0 0 1 0 0.967 0.885 1.000 206 NFATPATHWAY Cardiac hypertrophy is induced by NF-ATc4 and GATA4, which are stimulated through calcineurin activated by CaMK. ACTA1, AGT, AKT1, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK1G, CAMK4, CREBBP, CSNK1A1, CTF1, DTR, EDN1, ELSPBP1, F2, FGF2, FKBP1A, GATA4, GSK3B, HAND1, HAND2, HRAS, IGF1, LIF, MAP2K1, MAPK1, MAPK14, MAPK3, MAPK8, MEF2C, MYH2, NFATC1, NFATC2, NFATC3, NFATC4, NKX2-5, NPPA, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RAF1, RPS6KB1, SYT1 51 AGT(1), AKT1(2), CALM2(1), CALR(1), CAMK1(1), CAMK4(1), CREBBP(4), CSNK1A1(1), ELSPBP1(1), F2(3), FGF2(1), GATA4(1), HRAS(1), MAPK14(1), MAPK3(1), MYH2(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NPPA(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KB1(1), SYT1(1) 30760856 64 59 61 9 6 11 7 29 11 0 0.0138 0.886 1.000 207 C21_STEROID_HORMONE_METABOLISM AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1) 5740192 6 6 6 0 0 0 1 5 0 0 0.303 0.886 1.000 208 HSA00140_C21_STEROID_HORMONE_METABOLISM Genes involved in C21-steroid hormone metabolism AKR1C4, AKR1D1, CYP11A1, CYP11B1, CYP11B2, CYP17A1, CYP21A2, HSD11B1, HSD11B2, HSD3B1, HSD3B2 11 CYP11A1(1), CYP11B2(2), CYP17A1(1), CYP21A2(1), HSD3B1(1) 5740192 6 6 6 0 0 0 1 5 0 0 0.303 0.886 1.000 209 EIF4PATHWAY The eIF-4F complex recognizes 5' mRNA caps, recruits RNA helicases, and maintains mRNA-ribosome bridging. AKT1, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4G1, EIF4G2, EIF4G3, FRAP1, GHR, IRS1, MAPK1, MAPK14, MAPK3, MKNK1, PABPC1, PDK2, PDPK1, PIK3CA, PIK3R1, PRKCA, PRKCB1, PTEN, RPS6KB1 22 AKT1(2), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G2(3), EIF4G3(3), GHR(1), IRS1(3), MAPK14(1), MAPK3(1), MKNK1(1), PABPC1(9), PDK2(1), PIK3CA(12), PIK3R1(2), PTEN(20), RPS6KB1(1) 17233400 66 61 63 13 5 14 6 23 17 1 0.102 0.890 1.000 210 HSA03060_PROTEIN_EXPORT Genes involved in protein export OXA1L, SEC61A2, SRP19, SRP54, SRP68, SRP72, SRP9, SRPR 8 OXA1L(1), SRP19(1), SRP68(2), SRP72(2), SRP9(1) 4691704 7 7 7 2 0 2 1 4 0 0 0.635 0.895 1.000 211 NGFPATHWAY Nerve growth factor (NGF) stimulates neural survival and proliferation via the TrkA and p75 receptors, which induce DAG and IP3 production and activate Ras. CSNK2A1, DPM2, ELK1, FOS, GRB2, HRAS, JUN, KLK2, MAP2K1, MAPK3, MAPK8, NGFB, NGFR, PIK3CA, PIK3R1, PLCG1, RAF1, SHC1, SOS1 18 DPM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), KLK2(1), MAPK3(1), NGFR(1), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6) 11480316 31 30 28 7 2 10 3 15 1 0 0.259 0.895 1.000 212 ACETYLCHOLINE_SYNTHESIS ACHE, CHAT, CHKA, PCYT1A, PDHA1, PDHA2, PEMT, SLC18A3 8 ACHE(1), PDHA1(1), PDHA2(1), SLC18A3(1) 4103632 4 4 4 1 0 0 0 2 2 0 0.868 0.899 1.000 213 BADPATHWAY When phosphorylated, BAD is inhibited by sequestration; when non-phosphorylated, it promotes apoptosis by inactivating pro-survival BCL-XL and BCL-2. ADCY1, AKT1, BAD, BAX, BCL2, BCL2L1, CSF2RB, IGF1, IGF1R, IL3, IL3RA, KIT, KITLG, PIK3CA, PIK3R1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, YWHAH 22 ADCY1(1), AKT1(2), CSF2RB(1), IL3(1), KIT(3), KITLG(2), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 13399418 33 33 30 7 3 7 3 18 2 0 0.177 0.900 1.000 214 P27PATHWAY p27 blocks the G1/S transition by inhibiting the checkpoint kinase cdk2/cyclin E and is inhibited by cdk2-mediated ubiquitination. CCNE1, CDK2, CDKN1B, CKS1B, CUL1, E2F1, NEDD8, RB1, RBX1, SKP1A, SKP2, TFDP1, UBE2M 12 CCNE1(2), CDK2(2), CUL1(3), E2F1(1), RB1(1), SKP2(1) 5409612 10 9 10 3 1 2 1 2 4 0 0.675 0.904 1.000 215 HSA00530_AMINOSUGARS_METABOLISM Genes involved in aminosugars metabolism AMDHD2, CHIA, CHIT1, CMAS, CTBS, CYB5R1, CYB5R3, GFPT1, GFPT2, GNE, GNPDA1, GNPDA2, GNPNAT1, HEXA, HEXB, HK1, HK2, HK3, LHPP, MTMR1, MTMR2, MTMR6, NAGK, NANS, NPL, PGM3, PHPT1, RENBP, UAP1 29 AMDHD2(1), CHIA(2), CHIT1(4), CYB5R1(2), CYB5R3(2), GFPT1(1), GFPT2(1), GNPDA1(1), HEXA(3), HK1(4), MTMR1(1), MTMR2(1), NAGK(2), NANS(2), NPL(1), RENBP(2) 17800239 30 28 30 4 5 3 5 13 4 0 0.0622 0.911 1.000 216 PGC1APATHWAY PCG-1a is expressed in skeletal muscle, heart muscle, and brown fat, and is a coactivator for receptors such as glucocorticoid receptor and thyroid hormone receptor. CALM1, CALM2, CALM3, CAMK1, CAMK1G, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, ESRRA, HDAC5, MEF2A, MEF2B, MEF2C, MEF2D, PPARA, PPARGC1, PPP3CA, PPP3CB, PPP3CC, SLC2A4, SYT1, YWHAH 23 CALM2(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), MEF2A(1), MEF2D(1), PPP3CA(1), PPP3CC(1), SLC2A4(1), SYT1(1) 12743303 14 14 14 1 2 1 1 7 3 0 0.172 0.912 1.000 217 IL10PATHWAY The cytokine IL-10 inhibits the inflammatory response by macrophages via activation of heme oxygenase 1. BLVRA, BLVRB, HMOX1, IL10, IL10RA, IL10RB, IL1A, IL6, JAK1, STAT1, STAT3, STAT5A, TNF 13 BLVRA(1), HMOX1(2), JAK1(4), STAT1(4), STAT3(1) 7417728 12 12 12 3 1 0 0 7 4 0 0.769 0.912 1.000 218 IFNAPATHWAY Interferon alpha, active in the immune response, binds to the IFN receptor and activates Jak1 and Tyk2, which phosphorylate Stat1 and Stat2. IFNA1, IFNAR1, IFNAR2, IFNB1, ISGF3G, JAK1, STAT1, STAT2, TYK2 8 IFNA1(2), IFNAR1(1), IFNB1(2), JAK1(4), STAT1(4), STAT2(3), TYK2(3) 6655388 19 19 19 5 1 4 2 7 5 0 0.427 0.912 1.000 219 NEUTROPHILPATHWAY Neutrophils are phagocytotic leukocytes that destroy foreign cells with reactive oxygen species or enzymatic digestion and express CD11 and CD18. CD44, ICAM1, ITGAL, ITGAM, ITGB2, PECAM1, SELE, SELL 8 CD44(1), ITGAL(4), ITGAM(3), ITGB2(1), SELE(4) 6658595 13 13 13 4 1 4 3 3 2 0 0.583 0.914 1.000 220 IL18PATHWAY Pro-inflammatory IL-18 is activated in macrophages by caspase-1 cleavage and, in conjunction with IL-12, stimulates Th1 cell differentiation. CASP1, IFNG, IL12A, IL12B, IL18, IL2 6 CASP1(1) 1903259 1 1 1 0 0 0 0 1 0 0 0.855 0.915 1.000 221 GATA3PATHWAY GATA-3 is a transcription factor that promotes differentiation of helper T cells into Th2 cells, which secrete cytokines IL4, IL5, and IL13. GATA3, IL13, IL4, IL5, JUNB, MAF, MAP2K3, MAPK14, NFATC1, NFATC2, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B 16 IL4(1), JUNB(2), MAF(1), MAP2K3(3), MAPK14(1), NFATC1(1), NFATC2(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1) 6884313 19 19 19 5 4 0 1 13 1 0 0.468 0.918 1.000 222 HSA00601_GLYCOSPHINGOLIPID_BIOSYNTHESIS_LACTOSERIES Genes involved in glycosphingolipid biosynthesis - lactoseries ABO, B3GALT1, B3GALT2, B3GALT5, B3GNT5, FUT1, FUT2, FUT3, ST3GAL3, ST3GAL4 10 ABO(1), B3GALT2(2), B3GNT5(1), FUT1(1), ST3GAL3(1) 4324396 6 6 6 3 1 0 1 1 3 0 0.933 0.922 1.000 223 DNAFRAGMENTPATHWAY DNA fragmentation during apoptosis is effected by DFF, a caspase-activated DNAse, and by endonuclease G. CASP3, CASP7, DFFA, DFFB, ENDOG, GZMB, HMGB1, HMGB2, TOP2A, TOP2B 10 CASP7(1), TOP2A(3), TOP2B(1) 6310068 5 5 5 0 2 1 0 2 0 0 0.278 0.924 1.000 224 P35ALZHEIMERSPATHWAY p35, a neuron-specific activator of cyclin-dependent kinase 5, is cleaved to p25 in Alzheimer's disease and promotoes hyperphosphorylated tau formation and apoptosis. APP, CAPN1, CAPNS1, CAPNS2, CDK5, CDK5R1, CSNK1A1, CSNK1D, GSK3B, MAPT, PPP2CA 11 CAPN1(2), CSNK1A1(1), MAPT(1), PPP2CA(1) 5781880 5 5 5 0 0 0 1 1 3 0 0.368 0.927 1.000 225 HSA04150_MTOR_SIGNALING_PATHWAY Genes involved in mTOR signaling pathway AKT1, AKT2, AKT3, BRAF, CAB39, DDIT4, EIF4B, EIF4EBP1, FIGF, FRAP1, GBL, HIF1A, IGF1, INS, KIAA1303, LYK5, MAPK1, MAPK3, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PRKAA1, PRKAA2, RHEB, RICTOR, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, STK11, TSC1, TSC2, ULK1, ULK2, ULK3, VEGFA, VEGFB, VEGFC 44 AKT1(2), AKT2(3), AKT3(2), BRAF(1), FIGF(2), HIF1A(3), MAPK3(1), PGF(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RHEB(4), RICTOR(3), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), STK11(1), TSC1(2), TSC2(4), ULK1(1), ULK2(1), ULK3(3) 32763066 62 59 56 8 5 13 8 27 9 0 0.00546 0.929 1.000 226 EIF2PATHWAY Eukaryotic initiation factor 2 (EIF2) initiates translation by transferring Met-tRNA to the 40S ribosome in a GTP-dependent process. EIF2AK3, EIF2AK4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF5, GSK3B, HRI, PPP1CA, PRKR 9 EIF2AK3(2), EIF2AK4(3), EIF2B5(1), EIF2S2(1), EIF5(2) 7115245 9 9 9 2 1 1 2 3 2 0 0.563 0.929 1.000 227 TRKAPATHWAY Nerve growth factor (NGF) promotes neuronal survival and proliferation by binding its receptor TrkA, which activates PI3K/AKT, Ras, and the MAP kinase pathway. AKT1, DPM2, GRB2, HRAS, KLK2, NGFB, NTRK1, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, SHC1, SOS1 12 AKT1(2), DPM2(1), GRB2(1), HRAS(1), KLK2(1), NTRK1(4), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6) 9495902 32 30 29 8 1 10 4 15 2 0 0.336 0.931 1.000 228 WNTPATHWAY The Wnt glycoprotein binds to membrane-bound receptors such as Frizzled to activate a number of signaling pathways, including that of beta-catenin. APC, AXIN1, BTRC, CCND1, CREBBP, CSNK1A1, CSNK1D, CSNK2A1, CTBP1, CTNNB1, DVL1, FRAT1, FZD1, GSK3B, HDAC1, MADH4, MAP3K7, MAP3K7IP1, MYC, NLK, PPARD, PPP2CA, TCF1, TLE1, WIF1, WNT1 22 APC(6), AXIN1(2), BTRC(2), CREBBP(4), CSNK1A1(1), CTBP1(1), CTNNB1(1), DVL1(1), FZD1(2), HDAC1(2), MAP3K7(1), MYC(1), PPARD(1), PPP2CA(1), TLE1(1), WIF1(1) 18016701 28 27 27 4 2 3 5 16 2 0 0.0782 0.933 1.000 229 HSA00440_AMINOPHOSPHONATE_METABOLISM Genes involved in aminophosphonate metabolism CARM1, CHPT1, HEMK1, LCMT1, LCMT2, METTL2B, METTL6, PCYT1A, PCYT1B, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, WBSCR22 16 CHPT1(1), LCMT1(1), LCMT2(3), PCYT1B(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1) 8602143 12 11 12 2 1 2 1 7 1 0 0.436 0.936 1.000 230 RIBOFLAVIN_METABOLISM ACP1, ACP2, ACP5, ACPP, ACPT, ENPP1, ENPP3, FLAD1, RFK, TYR 10 ACP1(1), ACP2(1), ACP5(2), ENPP3(1), FLAD1(2), TYR(3) 6009360 10 10 10 3 0 3 0 4 3 0 0.725 0.938 1.000 231 HSA00780_BIOTIN_METABOLISM Genes involved in biotin metabolism BTD, HLCS, SPCS1, SPCS3 4 SPCS1(1) 1919062 1 1 1 1 0 0 0 1 0 0 0.937 0.938 1.000 232 CLASSICPATHWAY The classic complement pathway is initiated by antibodies and promotes phagocytosis and lysis of foreign cells as well as activating the inflammatory response. C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9 11 C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2) 10747686 18 18 18 4 2 5 1 8 2 0 0.345 0.940 1.000 233 HSA00511_N_GLYCAN_DEGRADATION Genes involved in N-glycan degradation AGA, FLJ21865, FUCA1, FUCA2, GLB1, HEXA, HEXB, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NEU1, NEU2, NEU3, NEU4 15 AGA(1), FUCA2(1), GLB1(4), HEXA(3), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1) 12025433 19 17 19 3 2 2 3 11 1 0 0.223 0.945 1.000 234 CYTOKINEPATHWAY Intercellular signaling in the immune system occurs via secretion of cytokines, which promote antigen-dependent B and T cell response. IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL14, IL15, IL16, IL17, IL18, IL1A, IL2, IL3, IL4, IL5, IL6, IL8, IL9, LTA, TNF 20 IFNA1(2), IFNB1(2), IL15(1), IL16(4), IL3(1), IL4(1), LTA(1) 5980500 12 12 12 4 0 5 1 6 0 0 0.533 0.947 1.000 235 SA_REG_CASCADE_OF_CYCLIN_EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. CCNA1, CCNA2, CCND1, CCNE1, CCNE2, CDK2, CDK4, CDKN1B, CDKN2A, E2F1, E2F2, E2F4, PRB1 13 CCNA1(3), CCNE1(2), CDK2(2), CDK4(1), CDKN2A(3), E2F1(1), PRB1(2) 5508148 14 13 14 6 1 2 2 5 4 0 0.849 0.949 1.000 236 FBW7PATHWAY Cyclin E interacts with cell cycle checkpoint kinase cdk2 to allow transcription of genes required for S phase, including transcription of additional cyclin E. CCNE1, CDC34, CDK2, CUL1, E2F1, FBXW7, RB1, SKP1A, TFDP1 8 CCNE1(2), CDK2(2), CUL1(3), E2F1(1), FBXW7(1), RB1(1) 5264017 10 9 10 4 1 2 1 2 4 0 0.852 0.951 1.000 237 SARSPATHWAY The SARS coronavirus has a 30kb RNA genome containing rep, a large gene encoding viral protease Mpro. ANPEP, CKM, EIF4E, FBL, GPT, LDHA, LDHB, LDHC, MAPK14, NCL 10 ANPEP(6), EIF4E(1), FBL(1), GPT(1), LDHB(1), LDHC(1), MAPK14(1), NCL(3) 5538188 15 15 15 6 0 0 4 7 4 0 0.938 0.953 1.000 238 G2PATHWAY Activated Cdc2-cyclin B kinase regulates the G2/M transition; DNA damage stimulates the DNA-PK/ATM/ATR kinases, which inactivate Cdc2. ATM, ATR, BRCA1, CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CDC34, CDKN1A, CDKN2D, CHEK1, CHEK2, EP300, GADD45A, MDM2, MYT1, PLK, PRKDC, RPS6KA1, TP53, WEE1, YWHAH, YWHAQ 22 ATM(15), ATR(5), BRCA1(6), CDC25A(1), CDC25C(2), CDKN1A(1), CHEK2(1), EP300(6), MYT1(2), PRKDC(5), RPS6KA1(2), TP53(10), WEE1(1) 26752095 57 49 57 8 3 6 9 29 10 0 0.0494 0.953 1.000 239 PANTOTHENATE_AND_COA_BIOSYNTHESIS BCAT1, COASY, DPYD, DPYS, ENPP1, ENPP3, PANK1, PANK2, PANK3, PANK4, PPCS, UPB1 12 BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2) 8506571 15 14 15 4 1 3 4 5 2 0 0.449 0.956 1.000 240 HSA00920_SULFUR_METABOLISM Genes involved in sulfur metabolism BPNT1, CHST11, CHST12, CHST13, PAPSS1, PAPSS2, SULT1A1, SULT1A2, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SULT2B1, SUOX 11 CHST11(1), CHST12(1), PAPSS1(3), PAPSS2(2), SULT1A1(1), SULT2A1(1), SUOX(2) 5320563 11 11 11 4 2 0 4 1 4 0 0.827 0.957 1.000 241 VIPPATHWAY Apoptosis of activated T cells is inhibited by vasoactive intestinal peptide (VIP) and its relative PACAP. CALM1, CALM2, CALM3, CHUK, EGR2, EGR3, GNAQ, MAP3K1, MYC, NFATC1, NFATC2, NFKB1, NFKBIA, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, SYT1, VIP, VIPR2 27 CALM2(1), CHUK(1), EGR2(1), EGR3(1), MAP3K1(4), MYC(1), NFATC1(1), NFATC2(1), NFKB1(1), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), SYT1(1) 16701000 25 25 25 4 4 4 0 13 4 0 0.182 0.957 1.000 242 PPARGPATHWAY PPAR-gamma is a nuclear hormone receptor that is activated by fatty acids and regulates transcription through co-activations like Src-1 and Tif2. CREBBP, EP300, LPL, NCOA1, NCOA2, PPARBP, PPARG, PPARGC1, RXRA 7 CREBBP(4), EP300(6), LPL(1), NCOA1(2), NCOA2(2), PPARG(1) 11432703 16 16 16 3 2 2 4 7 1 0 0.261 0.958 1.000 243 HSA01032_GLYCAN_STRUCTURES_DEGRADATION Genes involved in degradation of glycan structures AGA, ARSB, FLJ21865, FUCA1, FUCA2, GALNS, GBA, GLB1, GNS, GUSB, HEXA, HEXB, HGSNAT, HPSE, HPSE2, HYAL1, HYAL2, IDS, IDUA, LCT, MAN2B1, MAN2B2, MAN2C1, MANBA, NAGLU, NEU1, NEU2, NEU3, NEU4, SPAM1 29 AGA(1), ARSB(1), FUCA2(1), GALNS(2), GBA(2), GLB1(4), GNS(1), GUSB(6), HEXA(3), HGSNAT(1), HPSE(2), HPSE2(3), HYAL1(1), HYAL2(1), IDS(2), IDUA(1), LCT(2), MAN2B2(2), MAN2C1(5), NEU1(1), SPAM1(4) 20800172 46 37 44 8 7 6 7 22 4 0 0.0524 0.959 1.000 244 STEMPATHWAY In the absence of infection, bone marrow stromal cells release hematopoietic cytokines; activated macrophages and Th cells induce hematopoiesis during infection. CD4, CD8A, CSF1, CSF2, CSF3, EPO, IL11, IL2, IL3, IL4, IL5, IL6, IL7, IL8, IL9 15 CD4(2), IL3(1), IL4(1) 3759317 4 4 4 2 0 1 1 2 0 0 0.848 0.959 1.000 245 HSA00624_1_AND_2_METHYLNAPHTHALENE_DEGRADATION Genes involved in 1- and 2-methylnaphthalene degradation ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ARD1A, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ESCO1, ESCO2, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1 22 ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), DHRS2(1), ESCO1(2), ESCO2(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1) 15436406 23 22 22 4 2 2 3 12 4 0 0.369 0.960 1.000 246 SETPATHWAY Cytotoxic T cells release perforin, which to allow entry into target cells of granzyme B, which activates caspases, and granzyme A, which induces caspase-independent apoptosis. ANP32A, APEX1, CREBBP, DFFA, DFFB, GZMA, GZMB, HMGB2, NME1, PRF1, SET 11 CREBBP(4), PRF1(1) 6511345 5 5 5 0 0 2 1 2 0 0 0.193 0.960 1.000 247 HSA00053_ASCORBATE_AND_ALDARATE_METABOLISM Genes involved in ascorbate and aldarate metabolism ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, MIOX, UGDH 9 ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), MIOX(2) 5230020 8 8 8 3 0 2 0 3 3 0 0.822 0.961 1.000 248 RBPATHWAY The ATM protein kinase recognizes DNA damage and blocks cell cycle progression by phosphorylating chk1 and p53, which normally inhibits Rb to allow G1/S transitions. ATM, CDC2, CDC25A, CDC25B, CDC25C, CDK2, CDK4, CHEK1, MYT1, RB1, TP53, WEE1, YWHAH 12 ATM(15), CDC25A(1), CDC25C(2), CDK2(2), CDK4(1), MYT1(2), RB1(1), TP53(10), WEE1(1) 11054004 35 29 35 8 2 4 6 14 9 0 0.400 0.962 1.000 249 SULFUR_METABOLISM BPNT1, PAPSS1, PAPSS2, SULT1A2, SULT1A3, SULT1A3, SULT1A4, SULT1E1, SULT2A1, SUOX 7 PAPSS1(3), PAPSS2(2), SULT2A1(1), SUOX(2) 3799740 8 8 8 3 1 0 4 1 2 0 0.701 0.965 1.000 250 ONE_CARBON_POOL_BY_FOLATE ALDH1L1, AMT, ATIC, ATP6V0C, SHMT1, DHFR, GART, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 15 ALDH1L1(2), ATIC(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3) 11147479 15 15 15 3 3 2 0 7 3 0 0.392 0.965 1.000 251 MCALPAINPATHWAY In integrin-mediated cell migration, calpains digest links between the actin cytoskeleton and focal adhesion proteins. ACTA1, CAPN1, CAPN2, CAPNS1, CAPNS2, CXCR3, EGF, EGFR, HRAS, ITGA1, ITGB1, MAPK1, MAPK3, MYL2, MYLK, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PTK2, PXN, TLN1, VIL2 24 CAPN1(2), EGF(4), EGFR(7), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTK2(1), TLN1(4) 20377128 40 39 39 7 6 4 4 18 8 0 0.200 0.965 1.000 252 CHONDROITIN B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(2) 3640818 4 4 4 2 1 2 0 1 0 0 0.656 0.966 1.000 253 HEPARAN_SULFATE_BIOSYNTHESIS B3GAT3, B4GALT7, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, XYLT1, XYLT2 8 B3GAT3(1), XYLT1(1), XYLT2(2) 3640818 4 4 4 2 1 2 0 1 0 0 0.656 0.966 1.000 254 HSA00670_ONE_CARBON_POOL_BY_FOLATE Genes involved in one carbon pool by folate ALDH1L1, AMT, ATIC, DHFR, FTCD, GART, MTFMT, MTHFD1, MTHFD1L, MTHFD2, MTHFR, MTHFS, MTR, SHMT1, SHMT2, TYMS 16 ALDH1L1(2), ATIC(1), FTCD(1), MTHFD1(4), MTHFD1L(2), MTHFR(1), SHMT1(2), SHMT2(3) 11799824 16 16 16 3 3 2 0 8 3 0 0.358 0.966 1.000 255 ST_ADRENERGIC Adrenergic receptors respond to epinephrine and norepinephrine signaling. AKT1, APC, AR, ASAH1, BF, BRAF, CAMP, CCL13, CCL15, CCL16, DAG1, EGFR, GAS, GNA11, GNA15, GNAI1, GNAQ, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, MAPK10, MAPK14, PHKA2, PIK3CA, PIK3CD, PIK3R1, PITX2, PTX1, PTX3, RAF1, SRC 34 AKT1(2), APC(6), AR(1), ASAH1(1), BRAF(1), EGFR(7), GNA15(1), GNAI1(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MAPK10(1), MAPK14(1), PHKA2(3), PIK3CA(12), PIK3R1(2), PITX2(1), SRC(2) 33003649 60 50 56 7 5 15 10 25 5 0 0.00118 0.967 1.000 256 HSA00410_BETA_ALANINE_METABOLISM Genes involved in beta-alanine metabolism ABAT, ABP1, ACADM, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, HIBCH, MLYCD, SMS, SRM, UPB1 25 ABAT(1), ABP1(5), ACADM(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(2), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(2), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2) 16448248 33 31 33 7 3 5 11 10 4 0 0.163 0.968 1.000 257 HSP27PATHWAY Hsp27 oligomers have molecular chaperone activity and protect heat-stressed cells against apoptosis. ACTA1, APAF1, BCL2, CASP3, CASP9, CYCS, DAXX, FAS, FASLG, HSPB1, HSPB2, IL1A, MAPKAPK2, MAPKAPK3, TNF, TNFRSF6 15 DAXX(4), FAS(1), FASLG(1), HSPB2(1) 6815254 7 7 7 2 1 1 1 4 0 0 0.625 0.969 1.000 258 LONGEVITYPATHWAY Caloric restriction in animals often increases lifespan, which may occur via decreased IGF receptor expression and consequent expression of stress-resistance proteins. AKT1, CAT, FOXO3A, GH1, GHR, HRAS, IGF1, IGF1R, PIK3CA, PIK3R1, SHC1, SOD1, SOD2, SOD3 12 AKT1(2), CAT(2), GHR(1), HRAS(1), PIK3CA(12), PIK3R1(2), SHC1(2) 8024432 22 22 19 6 1 7 3 9 2 0 0.407 0.970 1.000 259 GANGLIOSIDE_BIOSYNTHESIS B3GALT4, GALGT, SIAT4A, SIAT4B, SIAT7B, SIAT7D, SIAT9, ST3GAL1, ST3GAL2, ST3GAL4, ST3GAL5, ST6GALNAC2, ST6GALNAC4, ST8SIA1 8 B3GALT4(1), ST3GAL1(1), ST3GAL5(1), ST6GALNAC2(2), ST8SIA1(2) 3382326 7 7 7 3 0 2 1 4 0 0 0.684 0.970 1.000 260 CD40PATHWAY The CD40 receptor is a TNF-type receptor that regulates immunoglobulin expression in B cells and moderates T cell activation via T-cell expression of its ligand. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, TNFAIP3, TNFRSF5, TNFSF5, TRAF3, TRAF6 12 CHUK(1), IKBKAP(2), MAP3K1(4), MAP3K14(1), NFKB1(1), RELA(1), TRAF3(1), TRAF6(1) 11335637 12 12 12 2 0 3 0 3 6 0 0.446 0.970 1.000 261 SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes AKT1, AKT2, AKT3, BCR, BTK, CD19, CDKN2A, DAPP1, FLOT1, FLOT2, FOXO3A, GAB1, ITPR1, ITPR2, ITPR3, LYN, NR0B2, P101-PI3K, PDK1, PHF11, PIK3CA, PITX2, PLCG2, PPP1R13B, PREX1, PSCD3, PTEN, PTPRC, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SAG, SYK, TEC, VAV1 33 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CDKN2A(3), GAB1(1), ITPR1(2), ITPR2(8), ITPR3(3), PDK1(1), PHF11(1), PIK3CA(12), PITX2(1), PLCG2(1), PPP1R13B(3), PREX1(6), PTEN(20), PTPRC(6), RPS6KA1(2), RPS6KB1(1), SAG(2), SYK(1), TEC(5), VAV1(2) 34254072 91 82 88 15 6 18 9 32 25 1 0.00873 0.971 1.000 262 CARBON_FIXATION ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME2, ME3, PGK1, PKLR, PKM2, RPE, RPE, LOC440001, RPIA, TKT, TPI1 21 ALDOA(2), ALDOB(3), FBP1(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME2(2), ME3(2), PGK1(2), PKM2(1), RPE(1), TPI1(1) 10998103 23 22 23 6 0 3 4 6 10 0 0.608 0.974 1.000 263 CDK5PATHWAY Cdk5, a regulatory kinase implicated in neuronal development, represses Mek1, which downregulates the MAP kinase pathway. CDK5, CDK5R1, DPM2, EGR1, HRAS, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, NGFB, NGFR, RAF1 12 DPM2(1), EGR1(2), HRAS(1), KLK2(1), MAPK3(1), NGFR(1) 4965774 7 7 7 3 2 1 0 4 0 0 0.757 0.974 1.000 264 TOLLPATHWAY Toll-like receptors are activated by bacterial lipoproteins, lipopolysaccharides, and other surface molecules, and activate pro-inflammatory factors such as NF-kB. CD14, CHUK, ELK1, FOS, IKBKB, IKBKG, IRAK1, JUN, LY96, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK14, MAPK8, MYD88, NFKB1, NFKBIA, PGLYRP, PPARA, PRKR, RELA, SITPEC, TIRAP, TLR10, TLR2, TLR3, TLR4, TLR6, TLR7, TLR9, TOLLIP, TRAF6 31 CHUK(1), ELK1(1), IRAK1(3), JUN(2), LY96(1), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TLR10(1), TLR2(2), TLR4(2), TLR6(1), TLR7(2), TLR9(1), TRAF6(1) 22241562 31 29 31 4 2 6 1 14 8 0 0.112 0.975 1.000 265 NEUROTRANSMITTERSPATHWAY Biosynthesis of neurotransmitters DBH, GAD1, HDC, PNMT, TH, TPH1 6 DBH(2), TH(1), TPH1(1) 3613727 4 4 4 2 0 1 1 1 1 0 0.864 0.976 1.000 266 HSA00040_PENTOSE_AND_GLUCURONATE_INTERCONVERSIONS Genes involved in pentose and glucuronate interconversions AKR1B1, DCXR, GUSB, RPE, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, XYLB 25 AKR1B1(2), GUSB(6), RPE(1), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), XYLB(1) 16942394 32 28 30 6 2 5 6 12 7 0 0.227 0.977 1.000 267 LDLPATHWAY Low density lipoproteins (LDL) are present in blood plasma, contain cholesterol and triglycerides, and contribute to atherogenic plaque formation. ACAT1, CCL2, CSF1, IL6, LDLR, LPL 6 CCL2(1), LDLR(1), LPL(1) 3253171 3 3 3 2 0 2 0 1 0 0 0.850 0.979 1.000 268 ETCPATHWAY Energy is extracted from carbohydrates via oxidation and transferred to the mitochondrial electron transport chain, which couples ATP synthesis to the reduction of oxygen to water. ATP5A1, CYCS, GPD2, MTCO1, NDUFA1, SDHA, SDHB, SDHC, SDHD, UQCRC1 9 ATP5A1(2), SDHB(1), SDHD(1) 4061439 4 4 4 2 1 0 1 2 0 0 0.799 0.980 1.000 269 GLOBOSIDE_METABOLISM A4GALT, FUT1, FUT2, FUT9, GBGT1, GLA, HEXA, HEXB, NAGA, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, ST8SIA1 13 FUT1(1), GBGT1(2), HEXA(3), ST3GAL1(1), ST8SIA1(2) 6143964 9 9 9 3 2 1 1 5 0 0 0.600 0.980 1.000 270 RANKLPATHWAY RANK is a TNF-type receptor that promotes osteoclast differentiation and consequent bone resorbtion on binding RANK ligand produced by osteoblasts. FOS, FOSL1, FOSL2, IFNAR1, IFNAR2, IFNB1, ISGF3G, MAPK8, NFKB1, PRKR, RELA, TNFRSF11A, TNFSF11, TRAF6 12 IFNAR1(1), IFNB1(2), NFKB1(1), RELA(1), TRAF6(1) 6682612 6 6 6 2 0 4 0 1 1 0 0.664 0.982 1.000 271 HSA00710_CARBON_FIXATION Genes involved in carbon fixation ALDOA, ALDOB, ALDOC, FBP1, FBP2, GOT1, GOT2, GPT, GPT2, MDH1, MDH2, ME1, ME3, PGK1, PGK2, PKLR, PKM2, RPE, RPIA, TKT, TKTL1, TKTL2, TPI1 23 ALDOA(2), ALDOB(3), FBP1(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), MDH1(1), ME1(1), ME3(2), PGK1(2), PKM2(1), RPE(1), TKTL1(1), TKTL2(3), TPI1(1) 12309174 25 25 25 6 0 2 4 8 11 0 0.612 0.982 1.000 272 PHENYLALANINE_METABOLISM ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, DDC, EPX, GOT1, GOT2, HPD, LPO, MAOA, MAOB, MPO, PRDX1, PRDX2, PRDX5, PRDX6, TAT, TPO 22 ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), DDC(2), EPX(1), GOT1(2), GOT2(2), MAOA(1), MPO(4), PRDX1(1), PRDX5(1), TPO(3) 13461982 28 24 28 6 2 4 9 11 2 0 0.207 0.984 1.000 273 MPRPATHWAY Progesterone binding to its intracellular receptor activates the MAPK pathway and induces oocyte maturation; binding to membrane receptor inhibits adenylyl cyclase. ACTA1, ADCY1, CAP1, CCNB1, CDC2, CDC25C, GNAI1, GNAS, GNB1, GNGT1, HRAS, MAPK1, MAPK3, MYT1, PIN1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RPS6KA1, SRC 22 ADCY1(1), CDC25C(2), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYT1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RPS6KA1(2), SRC(2) 12410831 27 26 27 6 4 3 0 18 2 0 0.389 0.984 1.000 274 SODDPATHWAY Some members of the tumor necrosis factor receptor family have cytoplasmic death domains that promote apoptosis when active and are repressed by silencers called SODDs. BAG4, BIRC3, CASP8, FADD, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 10 BAG4(1), BIRC3(2), RIPK1(1), TNFRSF1A(1), TRADD(1) 4852865 6 6 6 3 0 3 1 1 1 0 0.770 0.985 1.000 275 KERATAN_SULFATE_BIOSYNTHESIS B3GNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT5, FUT8, SIAT4A, SIAT4B, SIAT6, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 10 B4GALT3(1), B4GALT5(1), ST3GAL1(1), ST3GAL3(1) 4775395 4 4 4 4 0 0 1 1 2 0 0.986 0.985 1.000 276 EICOSANOID_SYNTHESIS ALOX12, ALOX15, ALOX15B, ALOX5, ALOX5AP, DPEP1, GGT1, IPLA2(GAMMA), LTA4H, LTC4S, PLA2G2A, PLA2G6, PTGDS, PTGES, PTGIS, PTGS1, PTGS2, TBXAS1 17 ALOX15B(2), ALOX5(2), GGT1(2), LTA4H(4), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1) 9356670 20 19 19 5 1 3 6 6 4 0 0.386 0.986 1.000 277 ST_TYPE_I_INTERFERON_PATHWAY Type I interferon is an antiviral cytokine that induces a JAK-STAT type pathway leading to ISGF3 activation and a cellular antiviral response. IFNAR1, IFNB1, ISGF3G, JAK1, PTPRU, REG1A, STAT1, STAT2, TYK2 8 IFNAR1(1), IFNB1(2), JAK1(4), PTPRU(4), STAT1(4), STAT2(3), TYK2(3) 7631359 21 21 21 6 1 2 2 11 5 0 0.560 0.986 1.000 278 HSA04710_CIRCADIAN_RHYTHM Genes involved in circadian rhythm ARNTL, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1D, CSNK1E, NPAS2, NR1D1, PER1, PER2, PER3 11 ARNTL(1), CLOCK(1), PER1(4), PER2(3), PER3(1) 10468412 10 10 10 2 0 0 4 4 1 1 0.399 0.986 1.000 279 ST_INTERLEUKIN_4_PATHWAY Like IL-13, IL-4 is produced by Th2 cells on activation of the T cell antigen receptor, and by mast and basophil cells on activation of the IgE receptor. AKT1, AKT2, AKT3, CISH, GRB2, IARS, IL13RA1, IL2RG, IL4, IL4R, INPP5D, JAK1, JAK2, JAK3, NR0B2, PI3, PIK3CA, PPP1R13B, RPS6KB1, SERPINA4, SHC1, SOS1, SOS2, SRC, STAT6, TYK2 26 AKT1(2), AKT2(3), AKT3(2), GRB2(1), IARS(4), IL13RA1(1), IL4(1), IL4R(2), INPP5D(1), JAK1(4), JAK2(5), JAK3(3), PIK3CA(12), PPP1R13B(3), RPS6KB1(1), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT6(2), TYK2(3) 22603626 61 55 58 11 2 14 9 26 10 0 0.0744 0.987 1.000 280 FLUMAZENILPATHWAY Flumazenil is a benzodiazepine receptor antagonist that may induce protective preconditioning in ischemic cardiomyocytes. GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPX1, PRKCE, SOD1 9 GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), PRKCE(2) 4893734 8 8 8 4 0 0 1 5 2 0 0.939 0.987 1.000 281 NUCLEOTIDE_GPCRS ADORA1, ADORA2A, ADORA2B, ADORA3, GPR23, LTB4R, P2RY1, P2RY2, P2RY5, P2RY6 8 ADORA2A(1), ADORA2B(1), P2RY2(1) 3391119 3 3 3 5 0 0 0 2 1 0 0.994 0.988 1.000 282 HSA00532_CHONDROITIN_SULFATE_BIOSYNTHESIS Genes involved in chondroitin sulfate biosynthesis B3GALT6, B3GAT1, B3GAT2, B3GAT3, B4GALT7, ChGn, CHPF, CHST11, CHST12, CHST13, CHST14, CHST3, CHST7, CHSY-2, CHSY1, CSGlcA-T, DSE, GALNAC4S-6ST, GALNACT-2, UST, XYLT1, XYLT2 15 B3GAT1(2), B3GAT2(1), B3GAT3(1), CHST11(1), CHST12(1), CHST7(1), CHSY1(2), DSE(1), XYLT1(1), XYLT2(2) 7571863 13 13 13 4 2 4 0 5 2 0 0.433 0.989 1.000 283 ST_PAC1_RECEPTOR_PATHWAY The signaling peptide PACAP binds to its receptor, PAC1R, which activates adenylyl cyclase and phospholipase C. ASAH1, CAMP, DAG1, GAS, GNAQ, ITPKA, ITPKB, PACAP 6 ASAH1(1), ITPKA(1), ITPKB(1) 3566789 3 3 3 2 1 0 0 1 1 0 0.926 0.990 1.000 284 SA_CASPASE_CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. ADPRT, APAF1, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP7, CASP8, CASP9, DFFA, DFFB, GZMB, PRF1, SCAP, SREBF1, SREBF2, TNFRSF6, TNFSF6 15 BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), PRF1(1), SCAP(1), SREBF1(2), SREBF2(3) 10984503 16 16 16 4 1 5 1 6 3 0 0.495 0.991 1.000 285 HSA00533_KERATAN_SULFATE_BIOSYNTHESIS Genes involved in keratan sulfate biosynthesis B3GNT1, B3GNT2, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, CHST1, CHST2, CHST4, CHST6, FUT8, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4 16 B3GNT2(2), B3GNT7(1), B4GALT3(1), B4GALT4(2), CHST1(1), CHST4(1), ST3GAL1(1), ST3GAL3(1) 7106875 10 10 10 4 0 3 2 1 4 0 0.798 0.991 1.000 286 HSA00360_PHENYLALANINE_METABOLISM Genes involved in phenylalanine metabolism ABP1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, ARD1A, DDC, EPX, ESCO1, ESCO2, GOT1, GOT2, HPD, LPO, LYCAT, MAOA, MAOB, MIF, MPO, MYST3, MYST4, NAT5, NAT6, PNPLA3, PRDX6, SH3GLB1, TAT, TPO 26 ABP1(5), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), DDC(2), EPX(1), ESCO1(2), ESCO2(1), GOT1(2), GOT2(2), MAOA(1), MPO(4), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), TPO(3) 20920218 40 35 40 7 3 5 10 18 4 0 0.0994 0.991 1.000 287 HSA04210_APOPTOSIS Genes involved in apoptosis AIFM1, AKT1, AKT2, AKT3, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CAPN1, CAPN2, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHP, CHUK, CSF2RB, CYCS, DFFA, DFFB, ENDOG, FADD, FAS, FASLG, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1RAP, IL3, IL3RA, IRAK1, IRAK2, IRAK3, IRAK4, MAP3K14, MYD88, NFKB1, NFKB2, NFKBIA, NGFB, NTRK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, RELA, RIPK1, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF1A, TNFSF10, TP53, TRADD, TRAF2 81 AIFM1(3), AKT1(2), AKT2(3), AKT3(2), ATM(15), BID(1), BIRC2(3), BIRC3(2), CAPN1(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), CSF2RB(1), FAS(1), FASLG(1), IL1R1(1), IL1RAP(4), IL3(1), IRAK1(3), IRAK3(2), IRAK4(1), MAP3K14(1), NFKB1(1), NTRK1(4), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TRADD(1) 51677192 111 99 106 16 8 21 15 49 18 0 0.00245 0.991 1.000 288 ANDROGEN_AND_ESTROGEN_METABOLISM AKR1C4, AKR1D1, ARSB, ARSD, ARSE, CYP11B1, CYP11B2, HSD11B1, HSD11B2, HSD17B2, HSD17B3, HSD17B8, HSD3B1, HSD3B2, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4 30 ARSB(1), ARSD(1), ARSE(1), CYP11B2(2), HSD17B8(1), HSD3B1(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 16843009 19 18 19 3 1 2 3 6 7 0 0.290 0.992 1.000 289 IL3PATHWAY IL-3 promotes proliferation and differentiation of hematopoietic cells via a heterodimeric receptor that activates the Stat5 and MAP kinase pathways. CSF2RB, FOS, GRB2, HRAS, IL3, IL3RA, JAK2, MAP2K1, MAPK3, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 15 CSF2RB(1), GRB2(1), HRAS(1), IL3(1), JAK2(5), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1) 10810069 22 21 22 5 3 3 3 11 2 0 0.377 0.992 1.000 290 STAT3PATHWAY The STAT transcription factors are phosphorylated and activated by JAK kinases in response to cytokine signaling. FRAP1, JAK1, JAK2, JAK3, MAPK1, MAPK3, STAT3, TYK2 7 JAK1(4), JAK2(5), JAK3(3), MAPK3(1), STAT3(1), TYK2(3) 7221566 17 17 17 8 1 0 3 9 4 0 0.939 0.992 1.000 291 HSA03022_BASAL_TRANSCRIPTION_FACTORS Genes involved in basal transcription factors GTF2A1, GTF2A1L, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F1, GTF2F2, GTF2H1, GTF2H2, GTF2H3, GTF2H4, GTF2I, GTF2IRD1, LOC391764, STON1, TAF1, TAF10, TAF12, TAF13, TAF1L, TAF2, TAF4, TAF4B, TAF5, TAF5L, TAF6, TAF6L, TAF7, TAF7L, TAF9, TAF9B, TBPL1, TBPL2 32 GTF2A1(1), GTF2E2(2), GTF2F1(1), GTF2F2(1), GTF2H1(2), GTF2I(3), GTF2IRD1(1), STON1(1), TAF1(5), TAF13(1), TAF1L(4), TAF2(2), TAF4(2), TAF4B(2), TAF5(2), TAF5L(2), TAF6(1), TAF7L(4) 22125447 37 36 37 6 2 4 4 22 5 0 0.160 0.993 1.000 292 TIDPATHWAY On ligand binding, interferon gamma receptors stimulate JAK2 kinase to phosphorylate STAT transcription factors, which promote expression of interferon responsive genes. DNAJA3, HSPA1A, IFNG, IFNGR1, IFNGR2, IKBKB, JAK2, LIN7A, NFKB1, NFKBIA, RB1, RELA, TIP-1, TNF, TNFRSF1A, TNFRSF1B, TP53, USH1C, WT1 17 DNAJA3(1), IFNGR1(2), IFNGR2(1), JAK2(5), NFKB1(1), RB1(1), RELA(1), TNFRSF1A(1), TP53(10), USH1C(3), WT1(3) 11014022 29 27 29 9 2 5 4 11 7 0 0.654 0.993 1.000 293 IGF1RPATHWAY Insulin-like growth factor receptor IGF-1R promotes cell growth and inhibits apoptosis on binding of ligands IGF-1 and 2 via Ras activation and the AKT pathway. AKT1, BAD, GRB2, HRAS, IGF1R, IRS1, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, RAF1, SHC1, SOS1, YWHAH 15 AKT1(2), GRB2(1), HRAS(1), IRS1(3), MAPK3(1), PIK3CA(12), PIK3R1(2), SHC1(2), SOS1(6) 11398430 30 29 27 8 3 10 3 13 1 0 0.273 0.994 1.000 294 HSA00100_BIOSYNTHESIS_OF_STEROIDS Genes involved in biosynthesis of steroids CYP27B1, CYP51A1, DHCR24, DHCR7, EBP, FDFT1, FDPS, GGCX, GGPS1, HMGCR, HSD17B7, IDI1, IDI2, LSS, MVD, MVK, NQO1, NSDHL, PMVK, SC4MOL, SC5DL, SQLE, TM7SF2, VKORC1 24 DHCR7(2), FDPS(1), IDI1(1), IDI2(2), LSS(2), PMVK(1), SC4MOL(1), SC5DL(1), TM7SF2(1) 11924405 12 12 12 2 0 0 1 8 3 0 0.591 0.995 1.000 295 OVARIAN_INFERTILITY_GENES ATM, BMPR1B, CCND2, CDK4, CDKN1B, CEBPB, DAZL, DMC1, EGR1, ESR2, FSHR, GJA4, INHA, LHCGR, MLH1, MSH5, NCOR1, NR5A1, NRIP1, PGR, PRLR, PTGER2, SMPD1, VDR, ZP2 24 ATM(15), BMPR1B(1), CCND2(1), CDK4(1), EGR1(2), ESR2(1), GJA4(1), MLH1(1), NCOR1(3), NRIP1(6), PGR(1), PRLR(2), PTGER2(1), SMPD1(1), VDR(1), ZP2(1) 21016551 39 34 39 6 2 6 6 16 9 0 0.0707 0.995 1.000 296 HSA00072_SYNTHESIS_AND_DEGRADATION_OF_KETONE_BODIES Genes involved in synthesis and degradation of ketone bodies ACAT1, ACAT2, BDH1, BDH2, HMGCL, HMGCS1, HMGCS2, OXCT1, OXCT2 9 BDH1(1), BDH2(1), HMGCS1(1), HMGCS2(1), OXCT1(1) 4476618 5 5 5 3 0 1 0 3 1 0 0.949 0.995 1.000 297 AMINOSUGARS_METABOLISM CMAS, CYB5R3, GCK, GFPT1, GNE, GNPDA1, GNPDA2, HEXA, HEXB, HK1, HK2, HK3, PGM3, RENBP, UAP1 15 CYB5R3(2), GFPT1(1), GNPDA1(1), HEXA(3), HK1(4), RENBP(2) 10526097 13 12 13 3 3 0 2 6 2 0 0.488 0.995 1.000 298 SA_PROGRAMMED_CELL_DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. APAF1, BAD, BAK1, BAX, BCL10, BCL2, BCL2L1, BCL2L11, BID, CASP8AP2, CASP9, CES1 12 BCL10(1), BID(1), CASP8AP2(4), CES1(2) 7145394 8 8 8 3 0 1 0 4 3 0 0.874 0.996 1.000 299 UBIQUINONE_BIOSYNTHESIS NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2 15 NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1) 4381376 9 9 9 4 0 0 1 7 1 0 0.921 0.996 1.000 300 HSA00361_GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION Genes involved in gamma-hexachlorocyclohexane degradation ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ALPI, ALPL, ALPP, ALPPL2, CMBL, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, PON1, PON2, PON3 23 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP3A7(1), DHRS2(1), PON3(2) 10895365 19 18 19 5 1 5 2 9 2 0 0.407 0.996 1.000 301 NTHIPATHWAY Hemophilus influenzae infections activate NF-kB via several pathways, inducing the inflammatory response. CHUK, CREBBP, DUSP1, EP300, IKBKB, IL1B, IL8, MADH3, MADH4, MAP2K3, MAP2K6, MAP3K14, MAP3K7, MAPK11, MAPK14, MYD88, NFKB1, NFKBIA, NR3C1, RELA, TGFBR1, TGFBR2, TLR2, TNF 22 CHUK(1), CREBBP(4), EP300(6), MAP2K3(3), MAP2K6(1), MAP3K14(1), MAP3K7(1), MAPK14(1), NFKB1(1), RELA(1), TGFBR2(1), TLR2(2) 18349352 23 23 23 4 1 3 4 11 4 0 0.328 0.996 1.000 302 ACE_INHIBITOR_PATHWAY_PHARMGKB ACE, AGT, AGTR1, AGTR2, BDKRB2, KNG1, NOS3, REN 8 ACE(2), AGT(1), AGTR1(1), BDKRB2(1), KNG1(2), NOS3(2), REN(1) 5996482 10 9 10 4 1 2 2 4 1 0 0.701 0.996 1.000 303 REELINPATHWAY Reelin is secreted by neurons and recognized by receptors including cadherin related neuronal receptors, which promote phosphorylation of Dab1. CDK5, CDK5R1, DAB1, FYN, LRP8, RELN, VLDLR 7 DAB1(3), FYN(1), LRP8(1), RELN(3), VLDLR(2) 8652493 10 10 10 3 0 3 0 5 2 0 0.822 0.996 1.000 304 CHEMICALPATHWAY DNA damage promotes Bid cleavage, which stimulates mitochondrial cytochrome c release and consequent caspase activation, resulting in apoptosis. ADPRT, AKT1, APAF1, ATM, BAD, BAX, BCL2, BCL2L1, BID, CASP3, CASP6, CASP7, CASP9, CYCS, EIF2S1, PRKCA, PRKCB1, PTK2, PXN, STAT1, TLN1, TP53 20 AKT1(2), ATM(15), BID(1), CASP7(1), PTK2(1), STAT1(4), TLN1(4), TP53(10) 17122645 38 33 38 8 4 5 5 16 8 0 0.271 0.996 1.000 305 GPCRDB_CLASS_B_SECRETIN_LIKE ADCYAP1R1, CALCR, CALCRL, CD97, CRHR1, CRHR2, ELTD1, EMR1, EMR2, GCGR, GHRHR, GIPR, GLP1R, GLP2R, GPR64, LPHN1, LPHN2, LPHN3, PTHR1, PTHR2, SCTR, VIPR1, VIPR2 20 ADCYAP1R1(2), CALCR(1), CD97(3), CRHR2(1), ELTD1(2), EMR1(1), EMR2(2), GIPR(1), GLP1R(1), GLP2R(2), GPR64(2), LPHN1(1), LPHN2(2), LPHN3(7), SCTR(1), VIPR1(1) 17047766 30 28 30 6 3 4 3 16 4 0 0.186 0.996 1.000 306 FIBRINOLYSISPATHWAY Thrombin cleavage of fibrinogen results in rapid formation of fibrin threads that form a mesh to capture platelets and other blood cells into a clot. CPB2, F13A1, F2, F2R, FGA, FGB, FGG, PLAT, PLAU, PLG, SERPINB2, SERPINE1 12 F2(3), FGA(1), FGG(1), PLAT(2), PLAU(4), PLG(5) 8404887 16 16 16 5 0 1 3 8 4 0 0.737 0.997 1.000 307 HEME_BIOSYNTHESIS ALAD, ALAS1, ALAS2, CPOX, FECH, HMBS, PPOX, UROD, UROS 9 ALAS1(4), ALAS2(3), CPOX(1), FECH(2) 4773876 10 10 9 4 0 0 2 7 1 0 0.833 0.997 1.000 308 HSA00641_3_CHLOROACRYLIC_ACID_DEGRADATION Genes involved in 3-chloroacrylic acid degradation ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1 15 ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1) 8252375 13 13 12 5 1 1 0 7 4 0 0.910 0.997 1.000 309 ETSPATHWAY The Ets transcription factors are activated by Ras and promote macrophage differentiation. CSF1, CSF1R, DDX20, E2F1, E2F4, ETS1, ETS2, ETV3, FOS, HDAC2, HDAC5, HRAS, JUN, NCOR2, RBL1, RBL2, SIN3A, SIN3B 18 CSF1R(5), DDX20(4), E2F1(1), HRAS(1), JUN(2), NCOR2(4), RBL2(2), SIN3A(1), SIN3B(1) 16312283 21 21 21 4 0 3 2 12 4 0 0.290 0.997 1.000 310 HSA00720_REDUCTIVE_CARBOXYLATE_CYCLE Genes involved in reductive carboxylate cycle (CO2 fixation) ACLY, ACO1, ACO2, ACSS1, ACSS2, FH, IDH1, IDH2, LOC441996, MDH1, MDH2, SUCLA2 11 ACLY(3), ACO1(4), ACSS1(3), ACSS2(3), IDH1(2), MDH1(1) 8259902 16 15 16 5 1 3 2 7 3 0 0.594 0.997 1.000 311 RELAPATHWAY Acetylated NF-kB proteins are immune to IkB regulation and promote transcription until the histone deacetylase HDAC3 deacetylates the RelA subunit of NF-kB. CHUK, CREBBP, EP300, FADD, HDAC3, IKBKB, IKBKG, NFKB1, NFKBIA, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 15 CHUK(1), CREBBP(4), EP300(6), NFKB1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF6(1) 13582745 17 17 17 4 0 4 5 5 3 0 0.397 0.998 1.000 312 1_2_DICHLOROETHANE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1) 4892942 7 7 7 5 0 1 1 4 1 0 0.971 0.998 1.000 313 ASCORBATE_AND_ALDARATE_METABOLISM ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1 8 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1) 4892942 7 7 7 5 0 1 1 4 1 0 0.971 0.998 1.000 314 HSA00740_RIBOFLAVIN_METABOLISM Genes involved in riboflavin metabolism ACP1, ACP2, ACP5, ACP6, ACPP, ACPT, ENPP1, ENPP3, FLAD1, LHPP, MTMR1, MTMR2, MTMR6, PHPT1, RFK, TYR 16 ACP1(1), ACP2(1), ACP5(2), ACP6(1), ENPP3(1), FLAD1(2), MTMR1(1), MTMR2(1), TYR(3) 9325297 13 13 13 4 0 3 0 7 3 0 0.754 0.998 1.000 315 PKCPATHWAY Gq-coupled receptors promote hydrolysis of PIP2 to DAG and IP3, which causes calcium influx and activates protein kinase C. GNAQ, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RELA 6 NFKB1(1), PLCB1(1), RELA(1) 5102963 3 3 3 3 0 2 0 0 1 0 0.921 0.998 1.000 316 HISTIDINE_METABOLISM ABP1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, AOC2, AOC3, ASPA, CNDP1, DDC, HAL, HARS, HARSL, HDC, HNMT, MAOA, MAOB, PRPS1, PRPS2 24 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), ASPA(1), CNDP1(3), DDC(2), HARS(1), MAOA(1), PRPS1(1), PRPS2(2) 15001144 29 27 29 7 2 6 7 12 2 0 0.269 0.998 1.000 317 HSA00791_ATRAZINE_DEGRADATION Genes involved in atrazine degradation ADAR, APOBEC1, APOBEC2, APOBEC3A, APOBEC3B, APOBEC3C, APOBEC3F, APOBEC3G, APOBEC4 9 ADAR(4), APOBEC1(1), APOBEC3B(1), APOBEC4(1) 4578285 7 6 7 5 1 0 2 3 1 0 0.951 0.998 1.000 318 ST_JAK_STAT_PATHWAY The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway transduces extracellular signals to promote gene activation. CISH, JAK1, JAK2, JAK3, PIAS1, PIAS3, PTPRU, REG1A, SOAT1 9 JAK1(4), JAK2(5), JAK3(3), PIAS1(2), PTPRU(4) 8521358 18 15 18 5 0 1 3 10 4 0 0.656 0.998 1.000 319 TNFR2PATHWAY Tumor necrosis factor beta, produced by activated lymphocytes, binds to its receptor TNFR2 to induce activation in immune cells and apoptosis in many other cells. CHUK, DUSP1, IKBKAP, IKBKB, IKBKG, LTA, MAP3K1, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNFAIP3, TNFRSF1B, TRAF1, TRAF2, TRAF3 17 CHUK(1), IKBKAP(2), LTA(1), MAP3K1(4), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TRAF3(1) 13819333 14 14 14 3 1 3 0 4 6 0 0.455 0.998 1.000 320 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Some Wnt glycoprotein/Frizzled receptor interactions increase intracellular calcium and decrease cGMP. BF, CAMK2A, CAMK2B, CAMK2D, CAMK2G, DAG1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFAT5, PDE6A, PDE6B, PDE6C, PDE6D, PDE6G, PDE6H, SLC6A13, TF 19 CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), NFAT5(7), PDE6A(1), PDE6B(2), PDE6C(2), SLC6A13(2) 22326766 34 30 33 6 4 3 6 17 4 0 0.121 0.998 1.000 321 HSA00280_VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION Genes involved in valine, leucine and isoleucine degradation ABAT, ACAA1, ACAA2, ACADM, ACADS, ACAT1, ACAT2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, AOX1, AUH, BCAT1, BCAT2, BCKDHA, BCKDHB, DBT, DLD, ECHS1, EHHADH, HADH, HADHA, HADHB, HIBADH, HIBCH, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, OXCT2, PCCA, PCCB 44 ABAT(1), ACADM(1), ACADS(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOX1(7), BCAT1(1), DLD(2), ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HADHB(2), HIBADH(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2) 26726464 46 46 45 9 4 7 10 19 6 0 0.140 0.998 1.000 322 ARENRF2PATHWAY Nrf1 and nrf2 are transcription factors that bind to antioxidant response elements (AREs), promoters of genes involved in oxidative damage control. CREB1, FOS, FXYD2, JUN, KEAP1, MAFF, MAFG, MAFK, MAPK1, MAPK14, MAPK8, NFE2L2, PRKCA, PRKCB1 12 JUN(2), KEAP1(2), MAPK14(1), NFE2L2(6) 5381736 11 11 11 5 0 1 2 7 1 0 0.864 0.998 1.000 323 HSA00340_HISTIDINE_METABOLISM Genes involved in histidine metabolism ABP1, ACY3, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, AMDHD1, AOC2, AOC3, ASPA, CARM1, CNDP1, DDC, FTCD, HAL, HARS, HARS2, HDC, HEMK1, HNMT, LCMT1, LCMT2, MAOA, MAOB, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, PRPS1, PRPS2, UROC1, WBSCR22 41 ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), AMDHD1(1), AOC2(2), AOC3(1), ASPA(1), CNDP1(3), DDC(2), FTCD(1), HARS(1), HARS2(1), LCMT1(1), LCMT2(3), MAOA(1), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), PRPS1(1), PRPS2(2), UROC1(1) 24273581 42 36 42 7 3 10 8 17 4 0 0.0534 0.998 1.000 324 COMPLEMENT_ACTIVATION_CLASSICAL C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C8B, C9, DAF, MASP1 13 C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), C8B(2), MASP1(1) 12799458 21 21 21 5 4 5 1 9 2 0 0.321 0.999 1.000 325 CELLCYCLEPATHWAY Cyclins interact with cyclin-dependent kinases to form active kinase complexes that regulate progression through the cell cycle. CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNH, CDC2, CDC25A, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CDKN2D, E2F1, RB1, RBL1, TFDP1 22 CCNA1(3), CCND2(1), CCNE1(2), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), E2F1(1), RB1(1) 9811377 18 17 18 7 1 3 2 7 5 0 0.818 0.999 1.000 326 S1PPATHWAY At low cholesterol concentrations, sterol-regulatory element binding proteins (SREBPs) act as transcription factors to promote cholesterol uptake and biosynthesis. EPLIN, HMGCS1, LDLR, MBTPS1, MBTPS2, SCAP, SREBF1, SREBF2 7 HMGCS1(1), LDLR(1), MBTPS1(2), SCAP(1), SREBF1(2), SREBF2(3) 7158734 10 10 10 4 1 3 1 2 3 0 0.785 0.999 1.000 327 SA_DIACYLGLYCEROL_SIGNALING DAG (diacylglycerol) signaling activity ESR1, ESR2, ITPKA, PDE1A, PDE1B, PLCB1, PLCB2, PRL, TRH, VIP 10 ESR2(1), ITPKA(1), PDE1A(1), PDE1B(2), PLCB1(1), PLCB2(2) 6781922 8 8 8 5 1 1 0 4 2 0 0.932 0.999 1.000 328 PAR1PATHWAY Activated extracellular thrombin cleaves and activates the G-protein coupled receptors PAR1 and PAR4, which activate platelets. ADCY1, ARHA, ARHGEF1, F2, F2R, F2RL3, GNA12, GNA13, GNAI1, GNAQ, GNB1, GNGT1, MAP3K7, PIK3CA, PIK3R1, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2B, ROCK1 19 ADCY1(1), ARHGEF1(1), F2(3), GNA13(4), GNAI1(1), GNB1(2), MAP3K7(1), PIK3CA(12), PIK3R1(2), PLCB1(1), PTK2B(2), ROCK1(4) 15834125 34 33 31 8 0 8 3 16 7 0 0.311 0.999 1.000 329 NOS1PATHWAY Glutamate stimulates NMDA-mediates calcium influx, which promotes nitric oxide synthesis from arginine by neuronal nitric oxide synthase, activating guanylate cyclase. CALM1, CALM2, CALM3, DLG4, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, NOS1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, SYT1 21 CALM2(1), DLG4(1), GRIN1(2), GRIN2A(4), GRIN2B(5), NOS1(8), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1) 15677959 33 32 33 9 6 7 1 19 0 0 0.362 0.999 1.000 330 COMPPATHWAY Both the classic and alternative immune complement pathways promote inflammation, foreign cell lysis, and phagocytosis. BF, C1QA, C1QB, C1QG, C1R, C1S, C2, C3, C4A, C4B, C5, C6, C7, C8A, C9, DF, MASP1, MASP2, MBL2 14 C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C5(4), C7(2), MASP1(1), MASP2(1), MBL2(1) 13155421 21 21 21 5 3 6 1 9 2 0 0.307 0.999 1.000 331 NO2IL12PATHWAY Macrophages activate NK cells by releasing IL-12, which induces NK cytotoxic activity in coordination with NO produced by inducible nitric oxide synthase II. CCR5, CD2, CD3D, CD3E, CD3G, CD3Z, CD4, CXCR3, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, JAK2, NOS2A, STAT4, TYK2 15 CD3E(2), CD3G(1), CD4(2), IL12RB1(1), IL12RB2(2), JAK2(5), STAT4(1), TYK2(3) 9171081 17 16 17 5 1 2 3 9 2 0 0.597 0.999 1.000 332 G1PATHWAY CDK4/6-cyclin D and CDK2-cyclin E phosphorylate Rb, which allows the transcription of genes needed for the G1/S cell cycle transition. ABL1, ATM, ATR, CCNA1, CCND1, CCNE1, CDC2, CDC25A, CDK2, CDK4, CDK6, CDKN1A, CDKN1B, CDKN2A, CDKN2B, DHFR, E2F1, GSK3B, HDAC1, MADH3, MADH4, RB1, SKP2, TFDP1, TGFB1, TGFB2, TGFB3, TP53 25 ABL1(4), ATM(15), ATR(5), CCNA1(3), CCNE1(2), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), E2F1(1), HDAC1(2), RB1(1), SKP2(1), TGFB2(2), TGFB3(1), TP53(10) 18505183 55 45 55 11 4 9 7 21 14 0 0.194 0.999 1.000 333 HSA00903_LIMONENE_AND_PINENE_DEGRADATION Genes involved in limonene and pinene degradation ACOT11, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, ARD1A, CYP2C19, CYP2C9, DHRS1, DHRS2, DHRS3, DHRS7, DHRSX, ECHS1, EHHADH, ESCO1, ESCO2, HADHA, LYCAT, MYST3, MYST4, NAT5, NAT6, PNPLA3, SH3GLB1, YOD1 26 ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CYP2C19(1), DHRS2(1), ECHS1(2), EHHADH(2), ESCO1(2), ESCO2(1), HADHA(1), MYST3(4), MYST4(4), PNPLA3(2), SH3GLB1(1), YOD1(1) 19051907 28 26 28 5 2 4 4 13 5 0 0.245 0.999 1.000 334 BETA_ALANINE_METABOLISM ABAT, ABP1, ACADL, ACADM, ACADSB, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, CNDP1, DPYD, DPYS, ECHS1, EHHADH, GAD1, GAD2, HADHA, MLYCD, SDS, SMS, UPB1 27 ABAT(1), ABP1(5), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(2), AOC3(1), CNDP1(3), DPYD(1), DPYS(2), ECHS1(2), EHHADH(2), GAD2(1), HADHA(1), MLYCD(1), SMS(2), UPB1(2) 17731273 34 32 34 9 3 5 12 11 3 0 0.307 0.999 1.000 335 ATP_SYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9429484 13 13 13 6 0 1 3 5 4 0 0.925 0.999 1.000 336 FLAGELLAR_ASSEMBLY ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9429484 13 13 13 6 0 1 3 5 4 0 0.925 0.999 1.000 337 TYPE_III_SECRETION_SYSTEM ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H 21 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9429484 13 13 13 6 0 1 3 5 4 0 0.925 0.999 1.000 338 MALATEXPATHWAY The tricarboxylate transfer pathway shuttles acetyl groups of acetyl-CoA between mitochondria and the cytoplasm. ACLY, CS, MDH1, ME1, PC, PDHA1, SLC25A1, SLC25A11 8 ACLY(3), CS(1), MDH1(1), ME1(1), PC(1), PDHA1(1) 5716800 8 8 8 4 0 3 0 4 1 0 0.761 0.999 1.000 339 VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, AOX1, BCAT1, BCKDHA, BCKDHB, ECHS1, EHHADH, HADHA, HADHB, HIBADH, HMGCL, IVD, MCCC1, MCCC2, MCEE, MUT, OXCT1, PCCA, PCCB, SDS 36 ACADM(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOX1(7), BCAT1(1), ECHS1(2), EHHADH(2), HADHA(1), HADHB(2), HIBADH(1), IVD(1), MCCC1(2), MCCC2(4), MCEE(1), MUT(2), OXCT1(1), PCCA(1), PCCB(2) 22330728 40 40 39 9 3 7 8 17 5 0 0.270 0.999 1.000 340 HSA03010_RIBOSOME Genes involved in ribosome C15orf15, FAU, hCG_1644323, hCG_1984468, hCG_2041321, hCG_21078, hCG_26523, LOC283412, LOC284064, LOC284230, LOC284288, LOC284393, LOC285053, LOC342994, LOC347292, LOC388720, LOC389342, LOC390876, LOC391656, LOC400652, LOC402057, LOC439992, LOC440055, LOC440589, LOC440733, LOC440737, LOC441377, LOC441876, LOC441907, MRPL13, MRPS7, RPL10A, RPL10L, RPL11, RPL12, RPL13, RPL13A, RPL14, RPL18, RPL18A, RPL19, RPL21, RPL22L1, RPL23A, RPL23AP2, RPL24, RPL26, RPL27, RPL27A, RPL28, RPL29, RPL3, RPL30, RPL31, RPL32, RPL34, RPL35, RPL35A, RPL36A, RPL36AL, RPL37, RPL37A, RPL38, RPL39, RPL3L, RPL41, RPL6, RPL7, RPL8, RPL9, RPS10, RPS11, RPS12, RPS13, RPS15A, RPS16, RPS18, RPS2, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26P10, RPS27, RPS28, RPS29, RPS3, RPS3A, RPS4Y1, RPS5, RPS6, RPS7, RPS8, RPS9, RPSA, tcag7.23 67 FAU(1), MRPS7(1), RPL10A(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22L1(1), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL7(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1) 14030803 32 31 32 7 2 3 6 17 4 0 0.290 0.999 1.000 341 ST_STAT3_PATHWAY The transcription factor STAT3 is involved in cell growth regulation and is commonly upregulated in tumors. CISH, IL6, IL6R, JAK1, JAK2, JAK3, PIAS3, PTPRU, REG1A, SRC, STAT3 11 JAK1(4), JAK2(5), JAK3(3), PTPRU(4), SRC(2), STAT3(1) 9373255 19 17 19 8 0 2 2 11 4 0 0.917 0.999 1.000 342 GABAPATHWAY Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter whose receptor is regulated by Plic-1, gephyrin, and GABARAP, which promote receptor clustering. DNM1, GABARAP, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GPHN, NSF, SRC, UBQLN1 12 DNM1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GPHN(3), SRC(2), UBQLN1(1) 7410165 13 13 13 5 0 4 3 4 2 0 0.751 1.000 1.000 343 KREBPATHWAY The Krebs (citric acid) cycle takes place in mitochondria, where it extracts energy in the form of electron carriers NADH and FADH2, which drive the electron transport chain. ACO2, CS, FH, IDH2, MDH1, OGDH, SDHA, SUCLA2 8 CS(1), MDH1(1), OGDH(3) 5886443 5 5 5 5 0 1 0 3 1 0 0.990 1.000 1.000 344 SRCRPTPPATHWAY Activation of Src by Protein-tyrosine phosphatase alpha CCNB1, CDC2, CDC25A, CDC25B, CDC25C, CSK, GRB2, PRKCA, PRKCB1, PTPRA, SRC 9 CDC25A(1), CDC25C(2), CSK(2), GRB2(1), PTPRA(1), SRC(2) 5682399 9 9 9 4 0 4 0 5 0 0 0.731 1.000 1.000 345 HSA00604_GLYCOSPHINGOLIPID_BIOSYNTHESIS_GANGLIOSERIES Genes involved in glycosphingolipid biosynthesis - ganglioseries B3GALT4, B4GALNT1, GLB1, HEXA, HEXB, LCT, SLC33A1, ST3GAL1, ST3GAL2, ST3GAL5, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5 16 B3GALT4(1), GLB1(4), HEXA(3), LCT(2), SLC33A1(2), ST3GAL1(1), ST3GAL5(1), ST6GALNAC3(2), ST6GALNAC5(1), ST8SIA1(2), ST8SIA5(1) 9926916 20 19 20 6 2 4 2 10 2 0 0.425 1.000 1.000 346 HSA04742_TASTE_TRANSDUCTION Genes involved in taste transduction ACCN1, ADCY4, ADCY6, ADCY8, CACNA1A, CACNA1B, GNAS, GNAT3, GNB1, GNB3, GNG13, GNG3, GRM4, ITPR3, KCNB1, PDE1A, PLCB2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, SCNN1A, SCNN1B, SCNN1G, TAS1R1, TAS1R2, TAS1R3, TAS2R1, TAS2R10, TAS2R13, TAS2R14, TAS2R16, TAS2R3, TAS2R38, TAS2R39, TAS2R4, TAS2R40, TAS2R41, TAS2R42, TAS2R43, TAS2R44, TAS2R45, TAS2R46, TAS2R48, TAS2R49, TAS2R5, TAS2R50, TAS2R60, TAS2R7, TAS2R8, TAS2R9, TRPM5 48 ACCN1(2), ADCY6(1), ADCY8(6), CACNA1A(5), CACNA1B(3), GNAS(4), GNB1(2), GNG3(1), GRM4(3), ITPR3(3), PDE1A(1), PLCB2(2), PRKACA(1), PRKACB(4), PRKACG(2), SCNN1A(2), SCNN1B(2), SCNN1G(1), TAS1R2(4), TAS1R3(2), TAS2R1(1), TAS2R13(1), TAS2R16(1), TAS2R3(2), TAS2R38(3), TAS2R39(1), TAS2R42(1), TAS2R43(1), TAS2R46(1), TAS2R50(1), TAS2R60(1), TAS2R8(1), TAS2R9(1), TRPM5(1) 35196925 68 60 67 11 13 4 7 29 15 0 0.0642 1.000 1.000 347 DCPATHWAY Dendritic cells internalize and present antigen, after which they migrate to lymphocyte-rich tissues and induce T and B cell differentiation. ANPEP, CD2, CD33, CD5, CD7, CSF2, IFNA1, IFNB1, IFNG, IL10, IL12A, IL12B, IL13, IL3, IL4, IL5, ITGAX, TLR2, TLR4, TLR7, TLR9, TNFRSF5 21 ANPEP(6), CD33(1), IFNA1(2), IFNB1(2), IL3(1), IL4(1), ITGAX(2), TLR2(2), TLR4(2), TLR7(2), TLR9(1) 11312503 22 22 22 7 2 5 5 9 1 0 0.568 1.000 1.000 348 STREPTOMYCIN_BIOSYNTHESIS GCK, HK1, HK2, HK3, IMPA1, PGM1, PGM3, TGDS 8 HK1(4) 6297228 4 3 4 3 2 0 0 1 1 0 0.925 1.000 1.000 349 PHOTOSYNTHESIS ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, FDXR 22 ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), SHMT1(2) 9951143 13 13 13 6 0 1 3 5 4 0 0.924 1.000 1.000 350 LYMPHOCYTEPATHWAY B and T cell lymphocytes interact with other cells via transmembrane adhesion proteins such as CD44, which interacts with endothelial cells. CD44, ICAM1, ITGA4, ITGAL, ITGB1, ITGB2, PECAM1, SELE, SELL 9 CD44(1), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELE(4) 7632567 14 14 14 5 1 4 4 3 2 0 0.647 1.000 1.000 351 HSA04115_P53_SIGNALING_PATHWAY Genes involved in p53 signaling pathway APAF1, ATM, ATR, BAI1, BAX, BBC3, BID, CASP3, CASP8, CASP9, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG1, CCNG2, CD82, CDC2, CDK2, CDK4, CDK6, CDKN1A, CDKN2A, CHEK1, CHEK2, CYCS, DDB2, EI24, FAS, GADD45A, GADD45B, GADD45G, GTSE1, IGF1, IGFBP3, LRDD, MDM2, MDM4, P53AIP1, PERP, PMAIP1, PPM1D, PTEN, RCHY1, RFWD2, RPRM, RRM2, RRM2B, SCOTIN, SERPINB5, SERPINE1, SESN1, SESN2, SESN3, SFN, SIAH1, STEAP3, THBS1, TNFRSF10B, TP53, TP53I3, TP73, TSC2, ZMAT3 65 ATM(15), ATR(5), BAI1(1), BID(1), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNG2(1), CD82(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK2(1), FAS(1), GTSE1(2), IGFBP3(1), LRDD(1), PTEN(20), RFWD2(2), RRM2(1), SERPINB5(3), STEAP3(2), THBS1(6), TP53(10), TP53I3(4), TP73(3), TSC2(4) 39981246 107 86 107 18 9 13 14 33 37 1 0.0270 1.000 1.000 352 ALKPATHWAY Activin receptor-like kinase 3 (ALK3) is required during gestation for cardiac muscle development. ACVR1, APC, ATF2, AXIN1, BMP10, BMP2, BMP4, BMP5, BMP7, BMPR1A, BMPR2, CHRD, CTNNB1, DVL1, FZD1, GATA4, GSK3B, MADH1, MADH4, MADH5, MADH6, MAP3K7, MEF2C, MYL2, NKX2-5, NOG, NPPA, NPPB, RFC1, TCF1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TGFBR3, WNT1 32 APC(6), ATF2(1), AXIN1(2), BMP2(1), BMP5(1), BMP7(2), BMPR2(4), CHRD(2), CTNNB1(1), DVL1(1), FZD1(2), GATA4(1), MAP3K7(1), MYL2(1), NPPA(1), NPPB(1), RFC1(4), TGFB2(2), TGFB3(1), TGFBR2(1), TGFBR3(1) 22030650 37 35 37 7 2 6 3 23 3 0 0.168 1.000 1.000 353 NFKBPATHWAY Inactive nuclear factor kB (NF-kB) is inhibited by the IkB family in the cytoplasm; active NF-kB is localized in the nucleus and regulates transcription of a variety of genes. CHUK, FADD, IKBKB, IKBKG, IL1A, IL1R1, IRAK1, MAP3K1, MAP3K14, MAP3K7, MAP3K7IP1, MYD88, NFKB1, NFKBIA, RELA, RIPK1, TLR4, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF6 21 CHUK(1), IL1R1(1), IRAK1(3), MAP3K1(4), MAP3K14(1), MAP3K7(1), NFKB1(1), RELA(1), RIPK1(1), TLR4(2), TNFRSF1A(1), TRADD(1), TRAF6(1) 14751144 19 18 19 6 1 5 1 4 8 0 0.652 1.000 1.000 354 BIOGENIC_AMINE_SYNTHESIS AANAT, ACHE, CHAT, COMT, DBH, DDC, DXYS155E, GAD1, GAD2, HDC, MAOA, PAH, PNMT, SLC18A3, TH, TPH1 15 ACHE(1), DBH(2), DDC(2), GAD2(1), MAOA(1), PAH(3), SLC18A3(1), TH(1), TPH1(1) 8603208 13 12 13 6 0 2 4 4 3 0 0.881 1.000 1.000 355 STRESSPATHWAY Tumor necrosis factor receptor TNFR1 promotes apoptosis and activates the pro-inflammatory NF-kB, while TNFR2 activates stress-activated protein kinases (SAPKs). ATF1, CASP2, CHUK, CRADD, IKBKB, IKBKG, JUN, LTA, MAP2K3, MAP2K4, MAP2K6, MAP3K1, MAP3K14, MAP4K2, MAPK14, MAPK8, NFKB1, NFKBIA, RELA, RIPK1, TANK, TNF, TNFRSF1A, TRADD, TRAF2 24 ATF1(2), CASP2(1), CHUK(1), JUN(2), LTA(1), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAP3K14(1), MAP4K2(1), MAPK14(1), NFKB1(1), RELA(1), RIPK1(1), TANK(1), TNFRSF1A(1), TRADD(1) 14782944 24 24 24 6 2 3 1 12 6 0 0.615 1.000 1.000 356 PENTOSE_PHOSPHATE_PATHWAY ALDOA, ALDOB, ALDOC, FBP1, FBP2, G6PD, GPI, H6PD, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPE, LOC440001, RPIA, TAL1, TALDO1, TALDO1, HSUP1, TKT 23 ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2) 12255271 17 17 17 8 0 3 2 6 6 0 0.922 1.000 1.000 357 PLCPATHWAY Phospholipase C hydrolyzes the membrane lipid PIP2 to DAG, which activates protein kinase C, and IP3, which causes calcium influx. AKT1, PIK3CA, PIK3R1, PLCB1, PLCG1, PRKCA, PRKCB1, VAV1 7 AKT1(2), PIK3CA(12), PIK3R1(2), PLCB1(1), VAV1(2) 7995805 19 19 16 8 1 7 3 6 2 0 0.685 1.000 1.000 358 MYOSINPATHWAY Myosin light chain kinase phosphorylates myosin and promotes muscle contraction and platelet formation; myosin phosphatase antagonizes these processes. ARHGAP5, ARHGEF1, GNA12, GNA13, GNAQ, GNB1, GNGT1, MYL2, MYLK, PLCB1, PPP1R12B, PRKCA, PRKCB1, PRKCL1, ROCK1 13 ARHGAP5(4), ARHGEF1(1), GNA13(4), GNB1(2), MYL2(1), MYLK(4), PLCB1(1), ROCK1(4) 12616665 21 21 21 7 0 1 0 14 6 0 0.835 1.000 1.000 359 ST_GAQ_PATHWAY G-alpha-q activates phospholipase C, resulting in calcium influx and increasing protein kinase C activity. ADRBK1, AKT1, AKT2, AKT3, BF, DAG1, GNAQ, IKBKG, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PIK3CB, PITX2, PLD1, PLD2, PLD3, VN1R1 26 ADRBK1(1), AKT1(2), AKT2(3), AKT3(2), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PITX2(1), PLD1(2), PLD2(2), PLD3(3) 27547566 39 32 39 6 3 8 6 16 6 0 0.0323 1.000 1.000 360 PITX2PATHWAY The bicoid-related transcription factor Pitx2 is activated by Wnt binding to the Frizzled receptor and induces tissue-specific cell proliferation. APC, AXIN1, CREBBP, CTNNB1, DVL1, EP300, FZD1, GSK3B, HDAC1, HTATIP, LDB1, LEF1, PITX2, PPARBP, TRRAP, WNT1 14 APC(6), AXIN1(2), CREBBP(4), CTNNB1(1), DVL1(1), EP300(6), FZD1(2), HDAC1(2), LDB1(1), LEF1(1), PITX2(1), TRRAP(3) 20298608 30 29 30 6 1 3 7 18 1 0 0.209 1.000 1.000 361 IL7PATHWAY IL-7 is required for B and T cell development and proliferation and may contribute to activation of VDJ recombination. BCL2, CREBBP, EP300, FYN, IL2RG, IL7, IL7R, JAK1, JAK3, LCK, NMI, PIK3CA, PIK3R1, PTK2B, STAT5A, STAT5B 16 CREBBP(4), EP300(6), FYN(1), JAK1(4), JAK3(3), PIK3CA(12), PIK3R1(2), PTK2B(2), STAT5B(1) 17367079 35 33 32 9 0 9 7 15 4 0 0.381 1.000 1.000 362 FEEDERPATHWAY Sugars such as mannose, galactose, and fructose are enzymatically converted to glucose via feeder pathways that lead to glycolysis. HK1, KHK, LCT, MPI, PGM1, PYGL, PYGM, TPI1, TREH 9 HK1(4), KHK(4), LCT(2), MPI(1), PYGL(1), PYGM(2), TPI1(1) 8385889 15 14 15 5 3 0 4 6 2 0 0.611 1.000 1.000 363 PROSTAGLANDIN_AND_LEUKOTRIENE_METABOLISM AKR1C3, ALOX12, ALOX15, ALOX5, CBR1, CBR3, CYP4F2, CYP4F3, CYP4F3, CYP4F2, EPX, GGT1, LPO, LTA4H, MPO, PGDS, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PRDX1, PRDX2, PRDX5, PRDX6, PTGDS, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1, TPO 31 ALOX5(2), CBR1(2), CYP4F2(1), EPX(1), GGT1(2), LTA4H(4), MPO(4), PLA2G4A(1), PLA2G6(2), PRDX1(1), PRDX5(1), PTGDS(1), PTGS1(1), PTGS2(4), TBXAS1(1), TPO(3) 17084735 31 31 30 8 4 5 8 10 4 0 0.280 1.000 1.000 364 HSA00521_STREPTOMYCIN_BIOSYNTHESIS Genes involved in streptomycin biosynthesis GCK, HK1, HK2, HK3, IMPA1, IMPA2, ISYNA1, PGM1, PGM3, TGDS 10 HK1(4), IMPA2(2) 7125667 6 5 6 4 3 0 0 2 1 0 0.924 1.000 1.000 365 PS1PATHWAY Presenilin is required for gamma-secretase activity to activate Notch signaling; presenilin also inhibits beta-catenin in the Wnt/Frizzled pathway. ADAM17, APC, AXIN1, BTRC, CTNNB1, DLL1, DVL1, FZD1, GSK3B, NOTCH1, PSEN1, RBPSUH, TCF1, WNT1 12 APC(6), AXIN1(2), BTRC(2), CTNNB1(1), DLL1(1), DVL1(1), FZD1(2), NOTCH1(3) 12458770 18 18 17 5 1 3 3 11 0 0 0.477 1.000 1.000 366 ST_G_ALPHA_S_PATHWAY The G-alpha-s protein activates adenylyl cyclases, which catalyze cAMP formation. ASAH1, BF, BFAR, BRAF, CAMP, CREB1, CREB3, CREB5, EPAC, GAS, GRF2, MAPK1, RAF1, SNX13, SRC, TERF2IP 12 ASAH1(1), BFAR(1), BRAF(1), SNX13(2), SRC(2) 7140864 7 7 7 5 0 3 0 3 1 0 0.948 1.000 1.000 367 HSA03050_PROTEASOME Genes involved in proteasome PSMA1, PSMA2, PSMA3, PSMA4, PSMA5, PSMA6, PSMA7, PSMB1, PSMB2, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSMC2, PSMC3, PSMD1, PSMD11, PSMD12, PSMD13, PSMD2, PSMD6 22 PSMA3(2), PSMA4(2), PSMA6(3), PSMB4(1), PSMB5(1), PSMB7(1), PSMD11(1), PSMD2(2), PSMD6(1) 9978802 14 14 14 5 1 2 1 7 3 0 0.853 1.000 1.000 368 MONOCYTEPATHWAY Monocytes are a class of immune phagocytes that can develop into macrophages and express LFA-1, CD44, and other surface signaling proteins. CD44, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, PECAM1, SELE, SELL, SELP 11 CD44(1), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), SELE(4), SELP(1) 10101136 18 18 18 7 1 5 5 4 3 0 0.750 1.000 1.000 369 GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM ACO1, ACO2, CS, GRHPR, HAO1, HAO2, HYI, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 12 ACO1(4), CS(1), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2) 7967216 14 14 14 5 3 1 1 8 1 0 0.670 1.000 1.000 370 LAIRPATHWAY The local acute inflammatory response is mediated by activated macrophages and mast cells or by complement activation. BDK, C3, C5, C6, C7, ICAM1, IL1A, IL6, IL8, ITGA4, ITGAL, ITGB1, ITGB2, SELP, SELPLG, TNF, VCAM1 16 C3(6), C5(4), C7(2), ITGA4(1), ITGAL(4), ITGB1(3), ITGB2(1), SELP(1), SELPLG(1), VCAM1(1) 15393560 24 24 24 7 2 4 4 10 4 0 0.507 1.000 1.000 371 LIMONENE_AND_PINENE_DEGRADATION ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ECHS1, EHHADH, HADHA, SDS 12 ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(2), HADHA(1) 7514224 12 12 12 5 1 3 2 5 1 0 0.764 1.000 1.000 372 CITRATE_CYCLE_TCA_CYCLE ACO1, ACO2, CS, DLD, DLST, DLSTP, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, MDH1, MDH2, PC, PCK1, SDHA, SDHA, SDHAL2, SDHB, SUCLA2, SUCLG1, SUCLG2 20 ACO1(4), CS(1), DLD(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), PC(1), PCK1(4), SDHB(1), SUCLG1(5), SUCLG2(1) 12807968 24 23 24 8 2 1 3 13 5 0 0.753 1.000 1.000 373 HSA00030_PENTOSE_PHOSPHATE_PATHWAY Genes involved in pentose phosphate pathway ALDOA, ALDOB, ALDOC, DERA, FBP1, FBP2, G6PD, GPI, H6PD, PFKL, PFKM, PFKP, PGD, PGLS, PGM1, PGM3, PRPS1, PRPS1L1, PRPS2, RBKS, RPE, RPIA, TALDO1, TKT, TKTL1, TKTL2 26 ALDOA(2), ALDOB(3), FBP1(1), G6PD(2), PFKL(1), PFKM(2), PRPS1(1), PRPS1L1(1), PRPS2(2), RPE(1), TALDO1(2), TKTL1(1), TKTL2(3) 14777530 22 22 22 8 0 4 2 9 7 0 0.818 1.000 1.000 374 CERAMIDEPATHWAY Ceramide is a lipid signaling molecule that can activate proliferative or apoptotic pathways, depending on signaling context, localization, and cell type. BAD, BAX, BCL2, CASP8, CYCS, FADD, MAP2K1, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, NFKB1, NSMAF, PDCD8, RAF1, RELA, RIPK1, SMPD1, TNFRSF1A, TRADD, TRAF2 21 MAP3K1(4), MAPK3(1), NFKB1(1), NSMAF(3), RELA(1), RIPK1(1), SMPD1(1), TNFRSF1A(1), TRADD(1) 12585853 14 14 14 5 1 4 1 3 5 0 0.598 1.000 1.000 375 IL12PATHWAY IL12 and Stat4 Dependent Signaling Pathway in Th1 Development CCR5, CD3D, CD3E, CD3G, CD3Z, CXCR3, ETV5, IFNG, IL12A, IL12B, IL12RB1, IL12RB2, IL18, IL18R1, JAK2, JUN, MAP2K6, MAPK14, MAPK8, STAT4, TRA@, TRB@, TYK2 20 CD3E(2), CD3G(1), IL12RB1(1), IL12RB2(2), IL18R1(1), JAK2(5), JUN(2), MAP2K6(1), MAPK14(1), STAT4(1), TYK2(3) 11604034 20 19 20 6 1 1 3 13 2 0 0.706 1.000 1.000 376 HSA00630_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM Genes involved in glyoxylate and dicarboxylate metabolism ACO1, ACO2, AFMID, CS, GRHPR, HAO1, HAO2, HYI, LOC441996, MDH1, MDH2, MTHFD1, MTHFD1L, MTHFD2 13 ACO1(4), CS(1), GRHPR(2), MDH1(1), MTHFD1(4), MTHFD1L(2) 8361460 14 14 14 5 3 1 1 8 1 0 0.668 1.000 1.000 377 HSA00290_VALINE_LEUCINE_AND_ISOLEUCINE_BIOSYNTHESIS Genes involved in valine, leucine and isoleucine biosynthesis BCAT1, BCAT2, IARS, IARS2, ILVBL, LARS, LARS2, PDHA1, PDHA2, PDHB, VARS, VARS2 12 BCAT1(1), IARS(4), IARS2(2), ILVBL(1), LARS(1), LARS2(1), PDHA1(1), PDHA2(1), PDHB(1), VARS(2), VARS2(1) 10458655 16 14 16 7 0 4 1 8 3 0 0.836 1.000 1.000 378 ALANINE_AND_ASPARTATE_METABOLISM AARS, ABAT, ADSL, ADSS, AGXT, AGXT2, ASL, ASNS, ASPA, ASS, CAD, CRAT, DARS, DDO, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, PC 21 AARS(1), ABAT(1), ADSL(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), CAD(4), CRAT(1), DARS(1), GAD2(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), PC(1) 16111652 22 21 22 7 1 2 7 4 8 0 0.613 1.000 1.000 379 N_GLYCAN_BIOSYNTHESIS ALG3, ALG5, B4GALT1, B4GALT2, B4GALT3, B4GALT5, DDOST, DPAGT1, DPM1, FUT8, GCS1, MAN1A1, MAN1B1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, RPN1, RPN2, ST6GAL1 21 ALG3(1), ALG5(1), B4GALT3(1), B4GALT5(1), DPAGT1(2), DPM1(1), MAN1A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), RPN1(2), RPN2(1) 11842267 17 17 17 9 0 4 0 9 4 0 0.951 1.000 1.000 380 HSA00770_PANTOTHENATE_AND_COA_BIOSYNTHESIS Genes involved in pantothenate and CoA biosynthesis BCAT1, BCAT2, COASY, DPYD, DPYS, ENPP1, ENPP3, ILVBL, PANK1, PANK2, PANK3, PANK4, PPCDC, PPCS, UPB1, VNN1 16 BCAT1(1), COASY(1), DPYD(1), DPYS(2), ENPP3(1), ILVBL(1), PANK1(2), PANK2(3), PANK3(1), PANK4(1), UPB1(2), VNN1(1) 10603495 17 16 17 6 1 3 4 6 3 0 0.710 1.000 1.000 381 HSA04620_TOLL_LIKE_RECEPTOR_SIGNALING_PATHWAY Genes involved in Toll-like receptor signaling pathway AKT1, AKT2, AKT3, CASP8, CCL3, CCL4, CCL5, CD14, CD40, CD80, CD86, CHUK, CXCL10, CXCL11, CXCL9, FADD, FOS, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IKBKB, IKBKE, IKBKG, IL12A, IL12B, IL1B, IL6, IL8, IRAK1, IRAK4, IRF3, IRF5, IRF7, JUN, LBP, LY96, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MYD88, NFKB1, NFKB2, NFKBIA, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, RAC1, RELA, RIPK1, SPP1, STAT1, TBK1, TICAM1, TICAM2, TIRAP, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TNF, TOLLIP, TRAF3, TRAF6 98 AKT1(2), AKT2(3), AKT3(2), CCL3(1), CD86(1), CHUK(1), CXCL11(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IKBKE(1), IRAK1(3), IRAK4(1), JUN(2), LBP(1), LY96(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), NFKB1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), RAC1(1), RELA(1), RIPK1(1), SPP1(2), STAT1(4), TICAM1(3), TLR1(1), TLR2(2), TLR4(2), TLR5(2), TLR6(1), TLR7(2), TLR8(4), TLR9(1), TRAF3(1), TRAF6(1) 54642634 97 86 93 14 6 20 12 51 8 0 0.00284 1.000 1.000 382 EPHA4PATHWAY Eph Kinases and ephrins support platelet aggregation ACTA1, EPHA4, EPHB1, FYN, ITGA1, ITGB1, L1CAM, LYN, RAP1B, SELP 10 EPHB1(1), FYN(1), ITGA1(3), ITGB1(3), L1CAM(4), SELP(1) 9750850 13 13 13 8 2 2 1 6 2 0 0.963 1.000 1.000 383 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. ACE, CD44, CSF1, FCGR3A, IL1B, IL6R, SELL, SPN, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, TNFRSF8, TNFSF8 15 ACE(2), CD44(1), SPN(1), TGFB2(2), TNFRSF1A(1), TNFSF8(1) 8078902 8 8 8 5 2 3 0 2 1 0 0.875 1.000 1.000 384 HDACPATHWAY Myocyte enhancer factor MEF2 activates transcription of genes required for muscle cell differentiation and is inhibited by histone deacetylases. AKT1, AVP, CABIN1, CALM1, CALM2, CALM3, CAMK1, CAMK1G, HDAC5, IGF1, IGF1R, INS, INSR, MAP2K6, MAPK14, MAPK7, MEF2A, MEF2B, MEF2C, MEF2D, MYOD1, NFATC1, NFATC2, PIK3CA, PIK3R1, PPP3CA, PPP3CB, PPP3CC, SYT1, YWHAH 30 AKT1(2), CABIN1(5), CALM2(1), CAMK1(1), INSR(3), MAP2K6(1), MAPK14(1), MEF2A(1), MEF2D(1), NFATC1(1), NFATC2(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), SYT1(1) 21068820 35 35 32 9 3 10 4 14 4 0 0.262 1.000 1.000 385 NITROGEN_METABOLISM AMT, ASNS, CA1, CA12, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUL, HAL 21 ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(2) 11750482 19 19 19 6 1 3 2 13 0 0 0.630 1.000 1.000 386 NO1PATHWAY Shear stress in endothelial cells increases cytoplasmic calcium, which activates nitric oxide synthase III to release NO, which in turn regulates cardiac contractions. ACTA1, AKT1, BDK, BDKRB2, CALM1, CALM2, CALM3, CAV1, CHRM1, CHRNA1, FLT1, FLT4, HSPCA, KDR, NOS3, PDE2A, PDE3A, PDE3B, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKG1, PRKG2, RYR2, SLC7A1, SYT1, TNNI1, VEGF 28 AKT1(2), BDKRB2(1), CALM2(1), CHRNA1(3), FLT1(4), FLT4(6), KDR(5), NOS3(2), PDE2A(1), PDE3A(4), PDE3B(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKG1(2), PRKG2(2), RYR2(9), SLC7A1(1), SYT1(1), TNNI1(1) 25547675 55 51 55 12 11 8 6 24 6 0 0.125 1.000 1.000 387 GAMMA_HEXACHLOROCYCLOHEXANE_DEGRADATION ACP1, ACP2, ACP5, ACPP, ACPT, ALPI, ALPL, ALPP, ALPP, ALPPL2, ALPPL2, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, PON1 31 ACP1(1), ACP2(1), ACP5(2), ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3) 17764358 31 28 31 8 4 9 0 15 3 0 0.228 1.000 1.000 388 HSA00150_ANDROGEN_AND_ESTROGEN_METABOLISM Genes involved in androgen and estrogen metabolism AKR1C4, AKR1D1, ARSD, ARSE, CARM1, CYP11B1, CYP11B2, CYP19A1, HEMK1, HSD11B1, HSD11B2, HSD17B1, HSD17B12, HSD17B2, HSD17B3, HSD17B7, HSD17B8, HSD3B1, HSD3B2, LCMT1, LCMT2, METTL2B, METTL6, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SRD5A1, SRD5A2, STS, SULT1E1, SULT2A1, SULT2B1, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, WBSCR22 54 ARSD(1), ARSE(1), CYP11B2(2), CYP19A1(2), HSD17B1(1), HSD17B8(1), HSD3B1(1), LCMT1(1), LCMT2(3), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SULT2A1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2) 30876617 41 38 41 8 4 5 6 18 8 0 0.242 1.000 1.000 389 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton ACTG1, ACTG2, ACTR2, ACTR3, AKT1, ANGPTL2, CDC42, CFL1, CFL2, FLNA, FLNC, FSCN1, FSCN2, FSCN3, GDI1, GDI2, LIMK1, MYH2, MYLK, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PFN1, PFN2, RHO, ROCK1, ROCK2, RPS4X, VASP, WASF1, WASL 34 ACTG1(2), ACTR2(1), AKT1(2), CDC42(1), CFL1(1), FLNA(3), FLNC(4), FSCN1(3), MYH2(7), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PFN2(1), RHO(1), ROCK1(4), ROCK2(3), WASL(6) 28974920 52 46 52 10 3 12 3 22 12 0 0.136 1.000 1.000 390 IRINOTECAN_PATHWAY_PHARMGKB ABCC1, ABCC2, ABCG2, BCHE, CES1, CES2, CES4, CYP3A4, CYP3A5, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6 17 ABCC1(2), ABCC2(1), BCHE(2), CES1(2), CES2(2), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2) 14211148 17 15 17 5 1 3 3 5 5 0 0.688 1.000 1.000 391 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. ATF2, BCR, BLNK, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK1, MAPK3, MAPK8IP3, PAPPA, RAC1, RPS6KA1, RPS6KA3, SHC1, SOS1, SYK, VAV1, VAV2, VAV3 24 ATF2(1), BCR(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK3(1), MAPK8IP3(1), PAPPA(1), RAC1(1), RPS6KA1(2), SHC1(2), SOS1(6), SYK(1), VAV1(2), VAV2(4) 19485389 32 29 32 8 4 5 3 17 3 0 0.332 1.000 1.000 392 GLYCINE_SERINE_AND_THREONINE_METABOLISM ABP1, AGXT, AGXT2, ALAS1, ALAS2, AMT, AOC2, AOC3, ATP6V0C, SHMT1, BHMT, CBS, CHDH, CHKA, CHKB, CHKB, CPT1B, CTH, DAO, DLD, DMGDH, GAMT, GARS, GATM, GCAT, GLDC, MAOA, MAOB, PEMT, PISD, PLCB2, PLCG1, PLCG2, PSPH, SARDH, SARS, SHMT1, SHMT2, TARS 37 ABP1(5), AGXT(1), AGXT2(1), ALAS1(4), ALAS2(3), AOC2(2), AOC3(1), BHMT(1), CHDH(2), CHKB(1), CTH(1), DAO(1), DLD(2), DMGDH(4), GATM(2), GLDC(1), MAOA(1), PISD(1), PLCB2(2), PLCG2(1), SARDH(2), SARS(3), SHMT1(2), SHMT2(3), TARS(2) 26059364 49 46 48 10 3 7 12 22 5 0 0.123 1.000 1.000 393 MONOAMINE_GPCRS ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, DRD1, DRD2, DRD3, DRD4, DRD5, HRH1, HRH2, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164 31 ADRA1A(1), ADRB2(2), CHRM2(2), CHRM3(2), CHRM5(2), DRD1(1), DRD2(1), DRD3(2), DRD5(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1) 15295241 26 25 26 8 4 3 2 13 4 0 0.559 1.000 1.000 394 UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS ACY1, ALDH18A1, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, GAMT, GATM, GLUD1, NAGS, OAT, ODC1, OTC, PYCR1, SMS 20 ALDH18A1(1), ARG1(1), ASL(1), CPS1(5), GATM(2), ODC1(1), OTC(1), PYCR1(1), SMS(2) 10815043 15 15 15 7 0 1 3 9 2 0 0.933 1.000 1.000 395 RARRXRPATHWAY RXR and RAR suppress transcription in the absence of ligand and, on binding trans- or 9-cis-retinoic acid, are ubiquitinated to allow transcription to proceed. ERCC3, GTF2A1, GTF2B, GTF2E1, GTF2F1, HDAC3, NCOA1, NCOA2, NCOA3, NCOR2, PCAF, POLR2A, RARA, RXRA, TBP 14 ERCC3(1), GTF2A1(1), GTF2F1(1), NCOA1(2), NCOA2(2), NCOA3(4), NCOR2(4), POLR2A(6), RARA(4), TBP(1) 15541685 26 23 26 9 1 4 6 9 6 0 0.600 1.000 1.000 396 ATMPATHWAY The tumor-suppressing protein kinase ATM responds to radiation-induced DNA damage by blocking cell-cycle progression and activating DNA repair. ABL1, ATM, BRCA1, CDKN1A, CHEK1, CHEK2, GADD45A, JUN, MAPK8, MDM2, MRE11A, NBS1, NFKB1, NFKBIA, RAD50, RAD51, RBBP8, RELA, TP53, TP73 19 ABL1(4), ATM(15), BRCA1(6), CDKN1A(1), CHEK2(1), JUN(2), NFKB1(1), RAD50(4), RAD51(2), RELA(1), TP53(10), TP73(3) 18215089 50 44 50 11 4 8 7 21 10 0 0.280 1.000 1.000 397 ST_JNK_MAPK_PATHWAY JNKs are MAP kinases regulated by several levels of kinases (MAPKK, MAPKKK) and phosphorylate transcription factors and regulatory proteins. AKT1, ATF2, CDC42, DLD, DUSP10, DUSP4, DUSP8, GAB1, GADD45A, GCK, IL1R1, JUN, MAP2K4, MAP2K5, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K9, MAPK10, MAPK7, MAPK8, MAPK9, MYEF2, NFATC3, NR2C2, PAPPA, SHC1, TP53, TRAF6, ZAK 38 AKT1(2), ATF2(1), CDC42(1), DLD(2), DUSP10(1), DUSP4(1), DUSP8(1), GAB1(1), IL1R1(1), JUN(2), MAP2K5(2), MAP2K7(1), MAP3K1(4), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAP3K9(1), MAPK10(1), MAPK9(2), NFATC3(3), NR2C2(1), PAPPA(1), SHC1(2), TP53(10), TRAF6(1), ZAK(1) 30785255 64 58 63 12 6 5 11 30 12 0 0.124 1.000 1.000 398 ST_MYOCYTE_AD_PATHWAY Cardiac myocytes have a variety of adrenergic receptors that induce subtype-specific signaling effects. ADRB1, AKT1, APC, ASAH1, BF, CAMP, CAV3, DAG1, DLG4, EPHB2, GAS, GNAI1, GNAQ, HTATIP, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PITX2, PLB, PTX1, PTX3, RAC1, RHO, RYR1 23 AKT1(2), APC(6), ASAH1(1), DLG4(1), EPHB2(1), GNAI1(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PITX2(1), RAC1(1), RHO(1), RYR1(11) 28105820 42 39 42 9 7 6 6 19 4 0 0.124 1.000 1.000 399 CDMACPATHWAY Cadmium 2+ promotes cell proliferation in cultured macrophages by entering the cell via calcium channels and activating the MAP kinase pathway. CUZD1, FOS, HRAS, JUN, MAP2K1, MAPK1, MAPK3, MYC, NFKB1, NFKBIA, PLCB1, PRKCA, PRKCB1, RAF1, RELA, TNF 15 CUZD1(2), HRAS(1), JUN(2), MAPK3(1), MYC(1), NFKB1(1), PLCB1(1), RELA(1) 9302000 10 10 10 5 3 2 0 4 1 0 0.787 1.000 1.000 400 ATRBRCAPATHWAY BRCA1 and 2 block cell cycle progression in response to DNA damage and promote double-stranded break repair; mutations induce breast cancer susceptibility. ATM, ATR, BRCA1, BRCA2, CHEK1, CHEK2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, HUS1, MRE11A, NBS1, RAD1, RAD17, RAD50, RAD51, RAD9A, TP53, TREX1 21 ATM(15), ATR(5), BRCA1(6), BRCA2(8), CHEK2(1), FANCA(4), FANCE(2), FANCF(2), FANCG(3), HUS1(2), RAD17(1), RAD50(4), RAD51(2), TP53(10), TREX1(1) 27398816 66 55 66 12 4 11 9 29 13 0 0.147 1.000 1.000 401 PELP1PATHWAY Pelp1 acts downstream of activated estrogen receptor to promote cell proliferation and is overexpressed in many breast tumors. CREBBP, EP300, ESR1, MAPK1, MAPK3, PELP1, SRC 7 CREBBP(4), EP300(6), MAPK3(1), PELP1(1), SRC(2) 9176202 14 14 14 5 1 3 4 5 1 0 0.666 1.000 1.000 402 TYROSINE_METABOLISM ABP1, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, COMT, DBH, DCT, DDC, FAH, GOT1, GOT2, GSTZ1, HGD, HPD, MAOA, MAOB, PNMT, TAT, TH, TPO, TYR 32 ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), GOT1(2), GOT2(2), HGD(1), MAOA(1), TH(1), TPO(3), TYR(3) 19435512 45 39 44 12 3 5 8 20 9 0 0.533 1.000 1.000 403 HSA00480_GLUTATHIONE_METABOLISM Genes involved in glutathione metabolism ANPEP, G6PD, GCLC, GCLM, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, GSR, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, OPLAH, TXNDC12 37 ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GPX6(1), GSR(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2), OPLAH(2), TXNDC12(1) 13487704 24 22 24 9 1 0 6 12 5 0 0.895 1.000 1.000 404 RNA_TRANSCRIPTION_REACTOME CCNH, CDK7, ERCC3, GTF2A2, GTF2B, GTF2E1, GTF2E2, GTF2F2, GTF2H1, GTF2H2, GTF2H4, ILK, MGC9850, MNAT1, POLR1A, POLR1B, POLR2A, POLR2B, POLR2C, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR3B, POLR3D, POLR3E, POLR3H, POLR3K, TAF12, TAF13, TAF5, TAF6, TAF7, TAF9, TBP, VARS2L 36 CCNH(1), ERCC3(1), GTF2E2(2), GTF2F2(1), GTF2H1(2), ILK(1), POLR1A(2), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3B(2), POLR3H(1), POLR3K(1), TAF13(1), TAF5(2), TAF6(1), TBP(1) 21473327 33 32 33 8 0 5 4 16 8 0 0.380 1.000 1.000 405 BILE_ACID_BIOSYNTHESIS ACAA1, ACAA2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1C4, AKR1D1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, SOAT2, SRD5A1, SRD5A2 27 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BAAT(1), HADHB(2), SOAT2(3) 14365999 19 18 18 8 1 2 2 10 4 0 0.942 1.000 1.000 406 HSA00910_NITROGEN_METABOLISM Genes involved in nitrogen metabolism AMT, ASNS, ASRGL1, CA1, CA12, CA13, CA14, CA2, CA3, CA4, CA5A, CA5B, CA6, CA7, CA8, CA9, CPS1, CTH, GLS, GLS2, GLUD1, GLUD2, GLUL, HAL 24 ASNS(1), CA14(2), CA5B(2), CA7(1), CA9(1), CPS1(5), CTH(1), GLS(4), GLS2(2) 13113172 19 19 19 6 1 3 2 13 0 0 0.628 1.000 1.000 407 PORPHYRIN_AND_CHLOROPHYLL_METABOLISM ALAD, BLVRA, BLVRB, CP, CPOX, EPRS, FECH, GUSB, HCCS, HMBS, HMOX1, HMOX2, PPOX, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UROD, UROS 26 BLVRA(1), CPOX(1), EPRS(2), FECH(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2) 16974408 27 24 25 8 2 4 4 12 5 0 0.625 1.000 1.000 408 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes AKT1, AKT2, AKT3, BAD, BCL2L1, CDC42, CDK2, CDKN1B, CDKN2A, CREB1, CREB3, CREB5, EBP, ERBB4, F2RL2, FOXO3A, FRAP1, GAB1, GADD45A, GRB2, GSK3A, GSK3B, IFI27, IGF1, IGFBP1, INPPL1, IRS1, IRS2, IRS4, MET, MYC, NOLC1, P101-PI3K, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARD3, PARD6A, PDK1, PIK3CA, PIK3CD, PPP1R13B, PREX1, PSCD3, PTEN, PTK2, PTPN1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KB1, SFN, SHC1, SLC2A4, SOS1, SOS2, TSC1, TSC2, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 62 AKT1(2), AKT2(3), AKT3(2), CDC42(1), CDK2(2), CDKN2A(3), ERBB4(6), F2RL2(1), GAB1(1), GRB2(1), GSK3A(2), INPPL1(2), IRS1(3), IRS4(1), MET(3), MYC(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARD3(2), PDK1(1), PIK3CA(12), PPP1R13B(3), PREX1(6), PTEN(20), PTK2(1), PTPN1(1), RPS6KA1(2), RPS6KB1(1), SHC1(2), SLC2A4(1), SOS1(6), SOS2(1), TSC1(2), TSC2(4), YWHAE(1) 46422402 108 95 105 21 7 18 9 46 27 1 0.0830 1.000 1.000 409 MITOCHONDRIAL_FATTY_ACID_BETAOXIDATION ACADL, ACADM, ACADS, ACADVL, ACSL1, ACSL3, ACSL4, CPT1A, CPT2, DCI, EHHADH, HADHA, HADHSC, MGC5139, PECR, SCP2, SLC25A20 15 ACADM(1), ACADS(2), ACSL3(1), ACSL4(1), CPT1A(1), EHHADH(2), HADHA(1), PECR(1), SCP2(2) 10425285 12 12 11 5 2 4 2 3 1 0 0.624 1.000 1.000 410 HSA04130_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT Genes involved in SNARE interactions in vesicular transport BET1, BET1L, BNIP1, C1orf142, GOSR1, GOSR2, SEC22B, SNAP23, SNAP25, SNAP29, STX10, STX11, STX12, STX16, STX17, STX18, STX19, STX2, STX3, STX4, STX5, STX6, STX7, STX8, TSNARE1, USE1, VAMP1, VAMP2, VAMP3, VAMP4, VAMP5, VAMP7, VAMP8, VTI1A, VTI1B, YKT6 35 BNIP1(1), GOSR1(1), SNAP23(1), STX10(1), STX16(1), STX19(1), STX2(1), STX4(1), STX7(2), STX8(1), TSNARE1(2) 10379706 13 12 13 6 1 2 1 8 1 0 0.797 1.000 1.000 411 IL2PATHWAY IL-2 promotes proliferation via JAK and MAP kinase and has surface receptors on activated B cells, LPS-treated monocytes, and many T cells. CSNK2A1, ELK1, FOS, GRB2, HRAS, IL2, IL2RA, IL2RB, IL2RG, JAK1, JAK3, JUN, LCK, MAP2K1, MAPK3, MAPK8, RAF1, SHC1, SOS1, STAT5A, STAT5B, SYK 22 ELK1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), JAK1(4), JAK3(3), JUN(2), MAPK3(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1) 14274671 26 25 26 9 3 4 2 13 4 0 0.743 1.000 1.000 412 HSA00061_FATTY_ACID_BIOSYNTHESIS Genes involved in fatty acid biosynthesis ACACA, ACACB, FASN, MCAT, OLAH, OXSM 6 ACACA(4), ACACB(3), FASN(3), OXSM(1) 9684314 11 11 11 5 1 0 4 5 1 0 0.827 1.000 1.000 413 PTDINSPATHWAY Phosphoinositide 3 kinase (PI3K) phosphorylate inositol rings of phosphoinositide lipids, influencing vesicle trafficking, cell proliferation, and migration. AKT1, AP2A1, AP2M1, ARF1, BAD, BTK, EEA1, GRASP, GSK3A, GSK3B, LYN, PDPK1, PFKL, PFKM, PFKP, PFKX, PLCG1, PRKCE, PRKCZ, RAB5A, RAC1, RPS6KB1, VAV2 22 AKT1(2), AP2A1(1), ARF1(1), BTK(1), EEA1(5), GSK3A(2), PFKL(1), PFKM(2), PRKCE(2), PRKCZ(2), RAB5A(1), RAC1(1), RPS6KB1(1), VAV2(4) 15614399 26 24 26 9 1 5 3 12 5 0 0.729 1.000 1.000 414 GLYCOSPHINGOLIPID_METABOLISM ARSA, ARSB, ARSD, ARSE, ASAH1, GAL3ST1, GALC, GBA, GBAP, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PPAP2A, PPAP2B, PPAP2C, SMPD1, SMPD2, SPTLC1, SPTLC2, UGCG 23 ARSB(1), ARSD(1), ARSE(1), ASAH1(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SMPD1(1), SMPD2(2), SPTLC1(1) 14356401 23 22 23 8 2 3 4 10 4 0 0.716 1.000 1.000 415 CARDIACEGFPATHWAY Cardiac hypertrophy, a response to high blood pressure, is stimulated by GPCR ligands such as angiotensin II that activate the EGF pathway. ADAM12, AGT, AGTR2, ARHA, EDN1, EDNRA, EDNRB, EGF, EGFR, FOS, HRAS, JUN, MYC, NFKB1, PLCG1, PRKCA, PRKCB1, RELA 16 ADAM12(1), AGT(1), EDNRB(1), EGF(4), EGFR(7), HRAS(1), JUN(2), MYC(1), NFKB1(1), RELA(1) 12588662 20 20 19 8 1 3 4 9 3 0 0.802 1.000 1.000 416 ST_ERK1_ERK2_MAPK_PATHWAY The Erk1 and Erk2 MAP kinase pathways are regulated by Raf, Mos, and Tpl-2. ARAF1, ATF1, BAD, BRAF, COPEB, CREB1, CREB3, CREB5, DUSP4, DUSP6, DUSP9, EEF2K, EIF4E, GRB2, HTATIP, MAP2K1, MAP2K2, MAP3K8, MAPK1, MAPK3, MKNK1, MKNK2, MOS, NFKB1, RAP1A, RPS6KA1, RPS6KA2, RPS6KA3, SHC1, SOS1, SOS2, TRAF3 29 ATF1(2), BRAF(1), DUSP4(1), DUSP9(1), EIF4E(1), GRB2(1), MAPK3(1), MKNK1(1), MKNK2(1), NFKB1(1), RAP1A(1), RPS6KA1(2), SHC1(2), SOS1(6), SOS2(1), TRAF3(1) 18245304 24 24 24 7 3 3 3 13 2 0 0.606 1.000 1.000 417 HSA00120_BILE_ACID_BIOSYNTHESIS Genes involved in bile acid biosynthesis ACAA1, ACAA2, ACAD8, ACAD9, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1B10, AKR1C4, AKR1D1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BAAT, CEL, CYP27A1, CYP7A1, HADHB, HSD3B7, LIPA, RDH11, RDH12, RDH13, RDH14, SLC27A5, SOAT1, SOAT2, SRD5A1, SRD5A2 38 ACAD8(1), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BAAT(1), HADHB(2), RDH11(3), SLC27A5(2), SOAT2(3) 19572845 27 26 26 8 3 3 2 14 5 0 0.686 1.000 1.000 418 FASPATHWAY Binding of the Fas ligand to the Fas receptor induces caspase activation and consequent apoptosis in the Fas-expressing cell. ADPRT, ARHGDIB, CASP10, CASP3, CASP6, CASP7, CASP8, CFLAR, DAXX, DFFA, DFFB, FADD, FAF1, JUN, LMNA, LMNB1, LMNB2, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, PTPN13, RB1, RIPK2, SPTAN1, TNFRSF6, TNFSF6 27 ARHGDIB(1), CASP10(3), CASP7(1), CFLAR(1), DAXX(4), JUN(2), LMNB1(1), MAP3K1(4), MAP3K7(1), PAK1(1), PRKDC(5), PTPN13(7), RB1(1), RIPK2(1), SPTAN1(5) 26303460 38 35 38 8 2 4 4 20 8 0 0.343 1.000 1.000 419 HSA00350_TYROSINE_METABOLISM Genes involved in tyrosine metabolism ABP1, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, AOC2, AOC3, AOX1, ARD1A, CARM1, COMT, DBH, DCT, DDC, ECH1, ESCO1, ESCO2, FAH, GOT1, GOT2, GSTZ1, HEMK1, HGD, HPD, LCMT1, LCMT2, LYCAT, MAOA, MAOB, METTL2B, METTL6, MIF, MYST3, MYST4, NAT5, NAT6, PNMT, PNPLA3, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, SH3GLB1, TAT, TH, TPO, TYR, TYRP1, WBSCR22 55 ABP1(5), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH3B1(1), ALDH3B2(2), AOC2(2), AOC3(1), AOX1(7), DBH(2), DCT(4), DDC(2), ECH1(1), ESCO1(2), ESCO2(1), GOT1(2), GOT2(2), HGD(1), LCMT1(1), LCMT2(3), MAOA(1), MYST3(4), MYST4(4), PNPLA3(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), SH3GLB1(1), TH(1), TPO(3), TYR(3), TYRP1(1) 36430512 72 60 71 15 5 8 13 34 12 0 0.201 1.000 1.000 420 HSA00563_GLYCOSYLPHOSPHATIDYLINOSITOL_ANCHOR_BIOSYNTHESIS Genes involved in glycosylphosphatidylinositol(GPI)-anchor biosynthesis GPAA1, GPLD1, PGAP1, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGW, PIGX, PIGZ 23 GPAA1(1), GPLD1(1), PGAP1(1), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1) 15100204 24 23 24 9 2 4 4 11 2 1 0.736 1.000 1.000 421 HSA04614_RENIN_ANGIOTENSIN_SYSTEM Genes involved in renin-angiotensin system ACE, ACE2, AGT, AGTR1, AGTR2, ANPEP, CMA1, CPA3, CTSA, CTSG, ENPEP, LNPEP, MAS1, MME, NLN, REN, THOP1 17 ACE(2), ACE2(1), AGT(1), AGTR1(1), ANPEP(6), CMA1(1), CTSA(1), ENPEP(4), LNPEP(3), MAS1(1), MME(3), REN(1) 13008111 25 23 24 9 1 2 8 12 2 0 0.794 1.000 1.000 422 BUTANOATE_METABOLISM AACS, ABAT, ACADS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH9A1, BDH, BUCS1, ECHS1, EHHADH, GAD1, GAD2, HADHA, HMGCL, L2HGDH, OXCT1, PDHA1, PDHA2, PDHB, SDHB, SDS 27 ABAT(1), ACADS(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(2), GAD2(1), HADHA(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), SDHB(1) 15916381 22 21 21 8 4 3 4 7 4 0 0.676 1.000 1.000 423 APOPTOSIS_KEGG APAF1, BAD, BAX, BCL2, BCL2A1, BCL2L1, BCL2L2, BOK, CASP1, CASP1, COPl, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CD40, CD40LG, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, FAS, FASLG, HRK, IKBKE, LTA, MCL1, NFKB1, NFKBIA, NGFB, NGFR, NR3C1, NTRK1, PTPN13, RIPK1, SFRS2IP, TFG, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF1, TRAF2, TRAF3, TRAF6 47 BCL2A1(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), DAXX(4), FAS(1), FASLG(1), IKBKE(1), LTA(1), NFKB1(1), NGFR(1), NTRK1(4), PTPN13(7), RIPK1(1), TNFRSF1A(1), TRADD(1), TRAF3(1), TRAF6(1) 26758848 34 33 34 8 2 4 4 18 6 0 0.453 1.000 1.000 424 METPATHWAY The hepatocyte growth factor receptor c-Met stimulates proliferation and alters cell motility and adhesion on binding the ligand HGF. ACTA1, CRK, CRKL, DOCK1, ELK1, FOS, GAB1, GRB2, GRF2, HGF, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAP4K1, MAPK1, MAPK3, MAPK8, MET, PAK1, PIK3CA, PIK3R1, PTEN, PTK2, PTK2B, PTPN11, PXN, RAF1, RAP1A, RAP1B, RASA1, SOS1, SRC, STAT3 35 DOCK1(1), ELK1(1), GAB1(1), GRB2(1), HGF(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAP4K1(1), MAPK3(1), MET(3), PAK1(1), PIK3CA(12), PIK3R1(2), PTEN(20), PTK2(1), PTK2B(2), PTPN11(1), RAP1A(1), RASA1(3), SOS1(6), SRC(2), STAT3(1) 27908220 71 62 68 17 3 18 4 24 21 1 0.344 1.000 1.000 425 CASPASEPATHWAY Caspases are cysteine proteases active in apoptosis; caspase-8 and 9 cleave and activate other caspases, while 3, 6, and 7 cleave cellular targets. ADPRT, APAF1, ARHGDIB, BIRC2, BIRC3, BIRC4, CASP1, CASP10, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, GZMB, LMNA, LMNB1, LMNB2, PRF1 21 ARHGDIB(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), LMNB1(1), PRF1(1) 11766669 14 14 14 5 0 4 2 7 1 0 0.724 1.000 1.000 426 HSA05050_DENTATORUBROPALLIDOLUYSIAN_ATROPHY Genes involved in dentatorubropallidoluysian atrophy (DRPLA) ATN1, BAIAP2, CASP1, CASP3, CASP7, CASP8, GAPDH, INS, INSR, ITCH, MAGI1, MAGI2, RERE, WWP1, WWP2 15 ATN1(1), CASP1(1), CASP7(1), INSR(3), MAGI1(2), MAGI2(3), RERE(2), WWP2(2) 14624161 15 15 14 7 2 2 2 6 3 0 0.932 1.000 1.000 427 ERKPATHWAY Cell growth is promoted by Ras activation of the anti-apoptotic p44/42 MAP kinase pathway. DPM2, EGFR, ELK1, GNAS, GNB1, GNGT1, GRB2, HRAS, IGF1R, ITGB1, KLK2, MAP2K1, MAP2K2, MAPK1, MAPK3, MKNK1, MKNK2, MYC, NGFB, NGFR, PDGFRA, PPP2CA, PTPRR, RAF1, RPS6KA1, RPS6KA5, SHC1, SOS1, SRC, STAT3 29 DPM2(1), EGFR(7), ELK1(1), GNAS(4), GNB1(2), GRB2(1), HRAS(1), ITGB1(3), KLK2(1), MAPK3(1), MKNK1(1), MKNK2(1), MYC(1), NGFR(1), PDGFRA(7), PPP2CA(1), PTPRR(3), RPS6KA1(2), SHC1(2), SOS1(6), SRC(2), STAT3(1) 20205250 50 47 49 13 4 10 6 25 5 0 0.342 1.000 1.000 428 LYSINE_DEGRADATION AADAT, AASDH, AASDHPPT, AASS, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, ATP6V0C, SHMT1, BAT8, BBOX1, DLST, DLSTP, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADHA, PLOD1, PLOD2, PLOD3, SDS, SHMT1, SHMT2, TMLHE 31 AASDH(3), AASDHPPT(2), AASS(4), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(2), EHMT1(1), EHMT2(3), HADHA(1), PLOD1(1), PLOD2(4), PLOD3(2), SHMT1(2), SHMT2(3), TMLHE(1) 21926674 42 39 42 11 4 8 4 16 10 0 0.356 1.000 1.000 429 AT1RPATHWAY Binding of angiotensin II to AT1-R activates Ca2+ signaling and the JNK pathway. AGT, AGTR1, ATF2, CALM1, CALM2, CALM3, EGFR, ELK1, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAPK1, MAPK3, MAPK8, MEF2A, MEF2B, MEF2C, MEF2D, PAK1, PRKCA, PRKCB1, PTK2, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 33 AGT(1), AGTR1(1), ATF2(1), CALM2(1), EGFR(7), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK3(1), MEF2A(1), MEF2D(1), PAK1(1), PTK2(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1) 20918023 39 36 38 10 5 9 5 16 4 0 0.374 1.000 1.000 430 DEATHPATHWAY Death receptors such as Fas and DR3, 4, and 5 transduce pro-apoptotic signaling by oligomerizing to activate the caspase cascade. APAF1, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP10, CASP3, CASP6, CASP7, CASP8, CASP9, CFLAR, CHUK, CYCS, DFFA, DFFB, FADD, GAS2, LMNA, MAP3K14, NFKB1, NFKBIA, RELA, RIPK1, SPTAN1, TNFRSF10A, TNFRSF10B, TNFRSF25, TNFSF10, TNFSF12, TRADD, TRAF2 32 BID(1), BIRC2(3), BIRC3(2), CASP10(3), CASP7(1), CFLAR(1), CHUK(1), GAS2(2), MAP3K14(1), NFKB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFSF10(1), TRADD(1) 20635809 25 24 25 8 1 4 3 11 6 0 0.711 1.000 1.000 431 HSA00591_LINOLEIC_ACID_METABOLISM Genes involved in linoleic acid metabolism AKR1B10, ALOX15, ALOX5, CYP1A2, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP3A4, CYP3A43, CYP3A5, CYP3A7, HSD3B7, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, RDH11, RDH12, RDH13, RDH14 31 AKR1B10(2), ALOX5(2), CYP1A2(3), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), RDH11(3) 14822445 19 19 19 7 3 2 2 10 2 0 0.670 1.000 1.000 432 IL2RBPATHWAY The beta subunit of the IL-2 receptor is required for IL-2 and IL-15 signal recognition and activates JAK kinase on ligand binding. AKT1, BAD, BCL2, BCL2L1, CBL, CFLAR, CRKL, E2F1, FOS, GRB2, HRAS, IL2RA, IL2RB, IL2RG, IRS1, JAK1, JAK3, MAPK1, MAPK3, MYC, NMI, PIK3CA, PIK3R1, PPIA, PTPN6, RAF1, RPS6KB1, SHC1, SOCS1, SOCS3, SOS1, STAT5A, STAT5B, SYK, TNFRSF6, TNFSF6, ZNFN1A3 33 AKT1(2), CBL(1), CFLAR(1), E2F1(1), GRB2(1), HRAS(1), IL2RA(2), IL2RB(1), IRS1(3), JAK1(4), JAK3(3), MAPK3(1), MYC(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RPS6KB1(1), SHC1(2), SOS1(6), STAT5B(1), SYK(1) 21772478 50 48 47 13 4 13 6 19 8 0 0.241 1.000 1.000 433 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor necrosis factor is a pro-inflammatory cytokine that activates NF-kB and c-Jun. BAG4, BIRC2, BIRC3, CASP3, CASP8, CFLAR, FADD, HRB, IKBKG, JUN, MAP2K4, MAP3K3, MAP3K7, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR2C2, RALBP1, RIPK1, TNF, TNFAIP3, TNFRSF1A, TNFRSF1B, TRADD, TRAF2 27 BAG4(1), BIRC2(3), BIRC3(2), CFLAR(1), JUN(2), MAP3K7(1), NFKB1(1), NFKBIB(1), NFKBIL1(1), NR2C2(1), RALBP1(1), RIPK1(1), TNFRSF1A(1), TRADD(1) 16105509 18 18 18 8 0 5 3 7 3 0 0.803 1.000 1.000 434 STATIN_PATHWAY_PHARMGKB ABCA1, APOA1, APOA1, LOC440837, APOA4, APOC1, APOC2, APOC3, APOC3, LOC440838, APOE, CETP, CYP7A1, DGAT1, HMGCR, LCAT, LDLR, LIPC, LPL, LRP1, SCARB1, SOAT1 18 ABCA1(7), LCAT(1), LDLR(1), LIPC(1), LPL(1), LRP1(10), SCARB1(2) 16773628 23 23 23 8 2 4 3 10 4 0 0.761 1.000 1.000 435 ST_GA13_PATHWAY G-alpha-13 influences the actin cytoskeleton and activates protein kinase D, PI3K, and Pyk2. AKT1, AKT2, AKT3, ARHGEF11, BCL2, BF, CDC42, DLG4, GNA13, IKBKG, LPA, MAP2K4, MAP3K1, MAP3K5, MAPK8, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PDK1, PHKA2, PI3, PIK3CB, PLD1, PLD2, PLD3, PRKCM, PTK2, RDX, ROCK1, ROCK2, SERPINA4, SRF, TBXA2R 34 AKT1(2), AKT2(3), AKT3(2), ARHGEF11(3), CDC42(1), DLG4(1), GNA13(4), LPA(2), MAP3K1(4), MAP3K5(5), NFKB1(1), NFKBIB(1), NFKBIL1(1), PDK1(1), PHKA2(3), PIK3CB(1), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RDX(1), ROCK1(4), ROCK2(3), SRF(1), TBXA2R(1) 30052384 53 48 53 11 2 6 6 27 12 0 0.254 1.000 1.000 436 EPOPATHWAY Erythropoietin, which activates the MAPK pathway, stimulates erythrocyte production and is an effective treatment for anemia. CSNK2A1, ELK1, EPO, EPOR, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MAPK8, PLCG1, PTPN6, RAF1, SHC1, SOS1, STAT5A, STAT5B 19 ELK1(1), GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PTPN6(3), SHC1(2), SOS1(6), STAT5B(1) 13158828 23 22 23 8 2 4 3 12 2 0 0.729 1.000 1.000 437 RIBOSOMAL_PROTEINS ANK2, APG10L, RPS23, B3GALT4, CDR1, DGKI, FAU, IL6ST, KIAA1394, LOC133957, MRPL19, NET_5, PIGK, RPL10, RPL11, RPL12, RPL13, RPL13, LOC388344, RPL13A, RPL13A, LOC283340, LOC387930, RPL14, RPL14, RPL14L, RPL15, RPL15, LOC136321, LOC402694, RPL17, RPL17, dJ612B15.1, RPL18, RPL18A, LOC285053, LOC347544, LOC390354, RPL18A, LOC390354, RPL19, RPL21, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC402336, LOC440487, LOC440575, RPL21, LOC387753, LOC388143, LOC388532, LOC388621, LOC389156, LOC390488, LOC440487, LOC440575, RPL22, RPL23, RPL24, RPL24, SLC36A2, RPL26, LOC391126, LOC392501, LOC400055, LOC441073, LOC441533, RPL27, RPL27A, RPL27A, LOC389435, RPL28, RPL29, RPL29, LOC283412, LOC284064, LOC389655, LOC391738, LOC401911, RPL3, RPL30, RPL31, RPL32, RPL34, LOC342994, RPL35, RPL35A, RPL36, RPL37, RPL38, RPL39, RPL3L, RPL4, RPL41, RPL5, RPL5, LOC388907, RPL5, RNU66, LOC388907, RPL6, RPL7, RPL7, LOC389305, RPL7, LOC90193, LOC388401, LOC389305, LOC392550, LOC439954, RPL7A, RPL7A, LOC133748, LOC388474, RPL7A, RNU36B, LOC133748, LOC388474, RPL8, RPL9, RPLP0, RPLP0, RPLP0_like, RPLP1, RPLP2, RPS10, RPS10, LOC158104, LOC388885, LOC389127, LOC390842, LOC401817, RPS10, LOC388885, RPS11, RPS12, RPS13, RPS14, RPS15, RPS16, RPS16, LOC441876, RPS17, RPS17, LOC402057, RPS18, RPS19, RPS2, RPS2, LOC91561, LOC148430, LOC286444, LOC400963, LOC440589, RPS20, RPS21, RPS23, RPS24, RPS25, RPS26, RPS26L, LOC440440, RPS27, RPS27A, RPS27A, LOC388720, LOC389425, RPS28, RPS29, RPS3, RPS3A, RPS3A, LOC146053, LOC400652, LOC401016, LOC439992, RPS4X, RPS4Y1, RPS5, RPS6, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6, RPS6KB1, RPS6KB2, RPS7, RPS8, RPS9, RPSA, LOC388524, LOC388654, SCDR10, TBC1D10C, TSPAN9, UBA52, UBB, UBC 93 ANK2(9), B3GALT4(1), FAU(1), IL6ST(3), PIGK(1), RPL11(1), RPL18(2), RPL18A(1), RPL19(1), RPL22(2), RPL27(2), RPL28(1), RPL3(1), RPL30(2), RPL31(1), RPL34(1), RPL3L(1), RPL4(2), RPL5(3), RPL7(1), RPLP0(1), RPS11(1), RPS13(1), RPS2(1), RPS21(2), RPS24(1), RPS26(1), RPS27(1), RPS27A(1), RPS29(1), RPS3(2), RPS3A(1), RPS4Y1(1), RPS6KA1(2), RPS6KA6(1), RPS6KB1(1), RPS6KB2(1), SLC36A2(1), TSPAN9(1), UBC(2) 32558147 61 56 60 12 5 5 15 25 11 0 0.0998 1.000 1.000 438 PYRIMIDINE_METABOLISM AK3, AK3L1, AK3L1, AK3L2, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ITPA, NME1, NME2, NP, NT5C, NT5E, NT5M, NUDT2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, RRM1, RRM2, TK1, TK2, TXNRD1, TYMS, UCK1, UCK2, UMPS, UNG, UPB1, UPP1 55 CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5M(2), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), RRM1(2), RRM2(1), TK1(1), TK2(1), UCK1(1), UCK2(1), UMPS(1), UNG(1), UPB1(2) 35180639 55 52 55 11 2 10 11 19 13 0 0.0717 1.000 1.000 439 CIRCADIAN_EXERCISE ARNTL, AZIN1, BTG1, C10orf110, C1orf1, CBX3, CEBPB, CLDN5, CLOCK, CRY1, CRY2, DAZAP2, DAZAP2, LOC401029, DNAJA1, EIF4G2, ETV6, G0S2, GENX_3414, GFRA1, GSTM3, GSTP1, HERPUD1, HLA_DMA, HSPA8, IDI1, KLF9, MAP3K7IP2, MYF6, NCKAP1, NCOA4, NR1D2, OAZIN, PER1, PER2, PIGF, PPP1R3C, PPP2CB, PSMA4, PURA, SF3A3, SUMO3, TOB1, TUBB3, UCP3, UGP2, VAPA, ZFR 39 ARNTL(1), BTG1(2), CLOCK(1), EIF4G2(3), ETV6(1), HERPUD1(1), HSPA8(6), IDI1(1), KLF9(2), MYF6(2), NCKAP1(1), NCOA4(3), NR1D2(1), PER1(4), PER2(3), PPP1R3C(1), PPP2CB(1), PSMA4(2), SF3A3(2), TOB1(2), TUBB3(3), UGP2(1), ZFR(6) 22468697 50 45 50 12 1 8 10 19 11 1 0.286 1.000 1.000 440 ST_B_CELL_ANTIGEN_RECEPTOR B cell receptors bind antigens and promote B cell activation. AKT1, AKT2, AKT3, BAD, BCR, BLNK, BTK, CD19, CSK, DAG1, EPHB2, GRB2, ITPKA, ITPKB, LYN, MAP2K1, MAP2K2, MAPK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PI3, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, RAF1, SERPINA4, SHC1, SOS1, SOS2, SYK, VAV1 39 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CSK(2), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PIK3CA(12), PIK3R1(2), PLCG2(1), PPP1R13B(3), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2) 31896980 56 48 52 12 4 16 6 24 6 0 0.0641 1.000 1.000 441 TNFR1PATHWAY Tumor necrosis factor alpha binds to its receptor TNFR1 and induces caspase-dependent apoptosis. ADPRT, ARHGDIB, BAG4, CASP2, CASP3, CASP8, CRADD, DFFA, DFFB, FADD, JUN, LMNA, LMNB1, LMNB2, MADD, MAP2K4, MAP3K1, MAP3K7, MAPK8, PAK1, PAK2, PRKDC, RB1, RIPK1, SPTAN1, TNF, TNFRSF1A, TRADD, TRAF2 28 ARHGDIB(1), BAG4(1), CASP2(1), JUN(2), LMNB1(1), MADD(4), MAP3K1(4), MAP3K7(1), PAK1(1), PRKDC(5), RB1(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1) 24293467 30 29 30 8 1 6 4 12 7 0 0.490 1.000 1.000 442 HSA00251_GLUTAMATE_METABOLISM Genes involved in glutamate metabolism ABAT, ADC, ALDH4A1, ALDH5A1, CAD, CPS1, EARS2, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GFPT2, GLS, GLS2, GLUD1, GLUD2, GLUL, GMPS, GNPNAT1, GOT1, GOT2, GPT, GPT2, GSR, GSS, NADSYN1, NAGK, PPAT, QARS 31 ABAT(1), ALDH4A1(1), CAD(4), CPS1(5), EPRS(2), GAD2(1), GFPT1(1), GFPT2(1), GLS(4), GLS2(2), GOT1(2), GOT2(2), GPT(1), GPT2(1), GSR(1), GSS(1), NAGK(2) 24484622 32 28 32 9 2 4 7 14 5 0 0.495 1.000 1.000 443 HSA00860_PORPHYRIN_AND_CHLOROPHYLL_METABOLISM Genes involved in porphyrin and chlorophyll metabolism ALAD, ALAS1, ALAS2, BLVRA, BLVRB, COX10, COX15, CP, CPOX, EARS2, EPRS, FECH, FTH1, FTMT, GUSB, HCCS, HMBS, HMOX1, HMOX2, MMAB, PPOX, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UROD, UROS 41 ALAS1(4), ALAS2(3), BLVRA(1), COX15(1), CPOX(1), EPRS(2), FECH(2), FTMT(2), GUSB(6), HCCS(1), HMOX1(2), HMOX2(1), MMAB(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2) 26178342 48 44 45 12 3 7 7 24 7 0 0.371 1.000 1.000 444 GLUTAMATE_METABOLISM ABAT, ALDH4A1, ALDH5A1, CAD, CPS1, EPRS, GAD1, GAD2, GCLC, GCLM, GFPT1, GLS, GLS2, GLUD1, GLUL, GMPS, GOT1, GOT2, GPT, GPT2, GSS, NADSYN1, PPAT, QARS 24 ABAT(1), ALDH4A1(1), CAD(4), CPS1(5), EPRS(2), GAD2(1), GFPT1(1), GLS(4), GLS2(2), GOT1(2), GOT2(2), GPT(1), GPT2(1), GSS(1) 20557233 28 25 28 9 1 4 5 13 5 0 0.663 1.000 1.000 445 MEF2DPATHWAY Mef2 transcription factors promote calcium-induced apoptosis in T cells and are regulated by MAP kinases and histone deacetylases. CABIN1, CALM1, CALM2, CALM3, CAPN2, CAPNS1, CAPNS2, EP300, HDAC1, HDAC2, MEF2D, NFATC1, NFATC2, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SYT1, TRA@, TRB@ 18 CABIN1(5), CALM2(1), EP300(6), HDAC1(2), MEF2D(1), NFATC1(1), NFATC2(1), PPP3CA(1), PPP3CC(1), SYT1(1) 14635976 20 19 20 8 3 2 3 11 1 0 0.764 1.000 1.000 446 HSA00071_FATTY_ACID_METABOLISM Genes involved in fatty acid metabolism ACAA1, ACAA2, ACADL, ACADM, ACADS, ACADSB, ACADVL, ACAT1, ACAT2, ACOX1, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CPT1A, CPT1B, CPT1C, CPT2, CYP4A11, CYP4A22, DCI, ECHS1, EHHADH, GCDH, HADH, HADHA, HADHB, HSD17B10, HSD17B4, PECI 47 ACADM(1), ACADS(2), ACOX1(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), CPT1A(1), CYP4A11(4), CYP4A22(1), ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HADHB(2), HSD17B4(1), PECI(1) 30408563 42 42 40 10 5 6 8 16 7 0 0.250 1.000 1.000 447 HSA03030_DNA_POLYMERASE Genes involved in DNA polymerase POLA1, POLA2, POLB, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLG, POLG2, POLH, POLI, POLK, POLL, POLM, POLQ, POLS, PRIM1, PRIM2, REV1, REV3L, RFC5 24 POLA1(1), POLB(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLG(2), POLG2(4), POLH(4), POLI(3), POLK(2), POLL(2), POLM(1), POLQ(5), PRIM1(2), PRIM2(3), REV1(1), REV3L(2), RFC5(1) 25562950 43 41 43 10 4 3 4 21 11 0 0.485 1.000 1.000 448 AMINOACYL_TRNA_BIOSYNTHESIS AARS, CARS, DARS, EPRS, FARS2, FARSLB, GARS, HARS, HARSL, IARS, KARS, LARS, LARS2, MARS, MARS2, NARS, QARS, RARS, SARS, TARS, WARS, WARS2, YARS 21 AARS(1), CARS(4), DARS(1), EPRS(2), HARS(1), IARS(4), KARS(1), LARS(1), LARS2(1), MARS(2), MARS2(3), SARS(3), TARS(2), WARS2(1), YARS(1) 19909360 28 27 28 9 0 4 5 16 3 0 0.659 1.000 1.000 449 MAPKPATHWAY The mitogen-activated protein (MAP) kinase pathway is a common signaling mechanism and has four main sub-pathways: Erk, JNK/SAPK, p53, and ERK5. ARAF1, ATF2, BRAF, CEBPA, CHUK, CREB1, DAXX, ELK1, FOS, GRB2, HRAS, IKBKB, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K11, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K8, MAP3K9, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAP4K5, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK4, MAPK6, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAX, MEF2A, MEF2B, MEF2C, MEF2D, MKNK1, MKNK2, MYC, NFKB1, NFKBIA, PAK1, PAK2, PDZGEF1, RAC1, RAF1, RELA, RIPK1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KB1, RPS6KB2, SHC1, SP1, STAT1, TGFB1, TGFB2, TGFB3, TGFBR1, TRADD, TRAF2 84 ATF2(1), BRAF(1), CHUK(1), DAXX(4), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K10(3), MAP3K11(1), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP3K9(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAP4K5(4), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK4(1), MAPK9(2), MAPKAPK5(1), MAX(3), MEF2A(1), MEF2D(1), MKNK1(1), MKNK2(1), MYC(1), NFKB1(1), PAK1(1), RAC1(1), RELA(1), RIPK1(1), RPS6KA1(2), RPS6KB1(1), RPS6KB2(1), SHC1(2), STAT1(4), TGFB2(2), TGFB3(1), TRADD(1) 59454728 95 82 94 17 11 10 7 46 21 0 0.0667 1.000 1.000 450 HSA04320_DORSO_VENTRAL_AXIS_FORMATION Genes involved in dorso-ventral axis formation BRAF, CPEB1, EGFR, ERBB2, ERBB4, ETS1, ETS2, ETV6, ETV7, FMN2, GRB2, KRAS, MAP2K1, MAPK1, MAPK3, NOTCH1, NOTCH2, NOTCH3, NOTCH4, PIWIL1, PIWIL2, PIWIL3, PIWIL4, RAF1, SOS1, SOS2, SPIRE1, SPIRE2 28 BRAF(1), CPEB1(3), EGFR(7), ERBB2(4), ERBB4(6), ETV6(1), FMN2(5), GRB2(1), KRAS(1), MAPK3(1), NOTCH1(3), NOTCH2(7), NOTCH3(6), NOTCH4(1), PIWIL1(2), PIWIL2(2), PIWIL3(3), PIWIL4(1), SOS1(6), SOS2(1), SPIRE1(1), SPIRE2(1) 30577295 64 58 63 16 6 8 7 33 10 0 0.415 1.000 1.000 451 TPOPATHWAY Thrombopoietin binds to its receptor and activates cell growth through the Erk and JNK MAP kinase pathways, protein kinase C, and JAK/STAT activation. CSNK2A1, FOS, GRB2, HRAS, JAK2, JUN, MAP2K1, MAPK3, MPL, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, RAF1, RASA1, SHC1, SOS1, STAT1, STAT3, STAT5A, STAT5B, THPO 22 GRB2(1), HRAS(1), JAK2(5), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), RASA1(3), SHC1(2), SOS1(6), STAT1(4), STAT3(1), STAT5B(1) 18406087 41 39 38 11 3 10 4 21 3 0 0.410 1.000 1.000 452 HSA00562_INOSITOL_PHOSPHATE_METABOLISM Genes involved in inositol phosphate metabolism CARKL, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5E, INPPL1, IPMK, ISYNA1, ITGB1BP3, ITPK1, ITPKA, ITPKB, MINPP1, MIOX, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 47 FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(1), MIOX(2), OCRL(1), PI4KA(8), PI4KB(1), PIK3C3(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD4(3), PLCE1(3), PLCG2(1), PTEN(20), PTPMT1(1), SYNJ1(4), SYNJ2(5) 45816746 95 83 91 21 5 15 8 34 32 1 0.219 1.000 1.000 453 HSA04610_COMPLEMENT_AND_COAGULATION_CASCADES Genes involved in complement and coagulation cascades A2M, BDKRB1, BDKRB2, C1QA, C1QB, C1QC, C1R, C1S, C2, C3, C3AR1, C4A, C4B, C4BPA, C4BPB, C5, C5AR1, C6, C7, C8A, C8B, C8G, C9, CD46, CD55, CD59, CFB, CFD, CFH, CFI, CPB2, CR1, CR2, F10, F11, F12, F13A1, F13B, F2, F2R, F3, F5, F7, F8, F9, FGA, FGB, FGG, KLKB1, KNG1, MASP1, MASP2, MBL2, PLAT, PLAU, PLAUR, PLG, PROC, PROS1, SERPINA1, SERPINA5, SERPINC1, SERPIND1, SERPINE1, SERPINF2, SERPING1, TFPI, THBD, VWF 66 A2M(3), BDKRB1(1), BDKRB2(1), C1QA(1), C1R(3), C1S(1), C2(1), C3(6), C3AR1(1), C4BPA(2), C5(4), C7(2), C8B(2), C8G(1), CD55(1), CFB(1), CFH(5), CR1(7), CR2(1), F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), KNG1(2), MASP1(1), MASP2(1), MBL2(1), PLAT(2), PLAU(4), PLAUR(2), PLG(5), PROC(4), PROS1(4), SERPINA1(2), SERPINF2(2), SERPING1(2), TFPI(1), VWF(5) 55525696 103 92 103 21 8 17 9 54 15 0 0.0747 1.000 1.000 454 ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS Rat-derived PC12 cells respond to nerve growth factor (NGF) and PACAP to differentiate into neuronal cells. AKT1, ASAH1, ATF1, BRAF, CAMP, CREB1, CREB3, CREB5, CREBBP, CRKL, DAG1, EGR1, EGR2, EGR3, EGR4, ELK1, FRS2, GAS, GNAQ, GRF2, JUN, MAP1B, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, NTRK1, OPN1LW, PACAP, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PTPN11, RPS6KA3, SH2B, SHC1, SRC, TERF2IP, TH, TUBA3 42 AKT1(2), ASAH1(1), ATF1(2), BRAF(1), CREBBP(4), EGR1(2), EGR2(1), EGR3(1), ELK1(1), FRS2(2), JUN(2), MAP1B(3), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), NTRK1(4), PIK3C2G(2), PIK3CA(12), PIK3R1(2), PTPN11(1), SHC1(2), SRC(2), TH(1) 31430907 57 51 54 15 6 14 5 24 8 0 0.259 1.000 1.000 455 ST_WNT_BETA_CATENIN_PATHWAY Beta-catenin is degraded in the absence of Wnt signaling; when extracellular Wnt binds Frizzled receptors, beta-catenin accumulates in the nucleus and may promote cell survival. AKT1, AKT2, AKT3, ANKRD6, APC, AXIN1, AXIN2, C22orf2, CER1, CSNK1A1, CTNNB1, DACT1, DKK1, DKK2, DKK3, DKK4, DVL1, FRAT1, FSTL1, GSK3A, GSK3B, IDAX, LAMR1, LRP1, MVP, NKD1, NKD2, PIN1, PSEN1, PTPRA, SENP2, SFRP1, TSHB, WIF1 30 AKT1(2), AKT2(3), AKT3(2), ANKRD6(2), APC(6), AXIN1(2), AXIN2(1), CER1(1), CSNK1A1(1), CTNNB1(1), DACT1(1), DKK2(1), DVL1(1), FSTL1(1), GSK3A(2), LRP1(10), MVP(3), NKD1(2), NKD2(1), PTPRA(1), WIF1(1) 24960163 45 43 45 12 4 8 7 21 5 0 0.375 1.000 1.000 456 ST_G_ALPHA_I_PATHWAY Gi and Go proteins are members of the same family that transduce cellular signals through both their alpha and beta subunits. AKT1, AKT2, AKT3, ASAH1, BF, BRAF, DAG1, DRD2, EGFR, EPHB2, GRB2, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, KCNJ3, KCNJ5, KCNJ9, MAPK1, PI3, PIK3CB, PITX2, PLCB1, PLCB2, PLCB3, PLCB4, RAF1, RAP1GA1, RGS20, SHC1, SOS1, SOS2, SRC, STAT3, TERF2IP 34 AKT1(2), AKT2(3), AKT3(2), ASAH1(1), BRAF(1), DRD2(1), EGFR(7), EPHB2(1), GRB2(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), PIK3CB(1), PITX2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), SHC1(2), SOS1(6), SOS2(1), SRC(2), STAT3(1) 36079091 59 52 58 14 7 11 8 28 5 0 0.136 1.000 1.000 457 PPARAPATHWAY Peroxisome proliferators regulate gene expression via PPAR/RXR heterodimers which bind to peroxisome-proliferator response elements (PPREs). ACOX1, APOA1, APOA2, CD36, CITED2, CPT1B, CREBBP, DUSP1, DUT, EHHADH, EP300, FABP1, FAT, FRA8B, HSD17B4, HSPA1A, HSPCA, INS, JUN, LPL, MAPK1, MAPK3, ME1, MRPL11, MYC, NCOA1, NCOR1, NCOR2, NFKBIA, NOS2A, NR0B2, NR1H3, NR2F1, NRIP1, PDGFA, PIK3CA, PIK3R1, PPARA, PPARBP, PPARGC1, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PTGS2, RB1, RELA, RXRA, SP1, SRA1, STAT5A, STAT5B, TNF 49 ACOX1(1), CREBBP(4), EHHADH(2), EP300(6), FABP1(1), HSD17B4(1), JUN(2), LPL(1), MAPK3(1), ME1(1), MYC(1), NCOA1(2), NCOR1(3), NCOR2(4), NR1H3(1), NRIP1(6), PIK3CA(12), PIK3R1(2), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PTGS2(4), RB1(1), RELA(1), SRA1(1), STAT5B(1) 38546269 68 63 65 16 4 16 11 34 3 0 0.113 1.000 1.000 458 BIOPEPTIDESPATHWAY Extracellular signaling peptides exert biological effects via G-protein coupled receptors (GPCRs), which activate intracellular GTPases. AGT, AGTR2, BDK, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDK5, F2, FYN, GNA11, GNAI1, GNB1, GNGT1, GRB2, HRAS, JAK2, MAP2K1, MAP2K2, MAPK1, MAPK14, MAPK3, MAPK8, MAPT, MYLK, PLCG1, PRKCA, PRKCB1, PTK2B, RAF1, SHC1, SOS1, STAT1, STAT3, STAT5A, SYT1 37 AGT(1), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), F2(3), FYN(1), GNAI1(1), GNB1(2), GRB2(1), HRAS(1), JAK2(5), MAPK14(1), MAPK3(1), MAPT(1), MYLK(4), PTK2B(2), SHC1(2), SOS1(6), STAT1(4), STAT3(1), SYT1(1) 25864845 44 41 44 12 4 6 6 23 5 0 0.464 1.000 1.000 459 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway AKT1, AKT2, AKT3, BAD, BCL2, BCR, BLNK, BTK, CD19, CD22, CD81, CR2, CSK, DAG1, FLOT1, FLOT2, GRB2, GSK3A, GSK3B, INPP5D, ITPR1, ITPR2, ITPR3, LYN, MAP4K1, MAPK1, MAPK3, NFATC1, NFATC2, NR0B2, PDK1, PIK3CA, PIK3CD, PIK3R1, PLCG2, PPP1R13B, PPP3CA, PPP3CB, PPP3CC, PTPRC, RAF1, SHC1, SOS1, SOS2, SYK, VAV1 46 AKT1(2), AKT2(3), AKT3(2), BCR(1), BTK(1), CD19(1), CD22(1), CR2(1), CSK(2), GRB2(1), GSK3A(2), INPP5D(1), ITPR1(2), ITPR2(8), ITPR3(3), MAP4K1(1), MAPK3(1), NFATC1(1), NFATC2(1), PDK1(1), PIK3CA(12), PIK3R1(2), PLCG2(1), PPP1R13B(3), PPP3CA(1), PPP3CC(1), PTPRC(6), SHC1(2), SOS1(6), SOS2(1), SYK(1), VAV1(2) 45144059 74 64 71 16 6 18 8 32 10 0 0.0522 1.000 1.000 460 ST_FAS_SIGNALING_PATHWAY The Fas receptor induces apoptosis and NF-kB activation when bound to Fas ligand. ADPRT, ALG2, BAK1, BAX, BFAR, BIRC4, BTK, CAD, CASP10, CASP3, CASP8, CASP8AP2, CD7, CDK2AP1, CSNK1A1, DAXX, DEDD, DEDD2, DFFA, DIABLO, EGFR, EPHB2, FADD, FAF1, FAIM2, FREQ, HRB, HSPB1, IL1A, IL8, MAP2K4, MAP2K7, MAP3K1, MAP3K5, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MCP, MET, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, NR0B2, PFN1, PFN2, PTPN13, RALBP1, RIPK1, ROCK1, SMPD1, TNFRSF6, TNFRSF6B, TP53, TPX2, TRAF2, TUFM, VIL2 59 BFAR(1), BTK(1), CAD(4), CASP10(3), CASP8AP2(4), CSNK1A1(1), DAXX(4), DEDD(2), EGFR(7), EPHB2(1), FAIM2(1), MAP2K7(1), MAP3K1(4), MAP3K5(5), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MET(3), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PFN2(1), PTPN13(7), RALBP1(1), RIPK1(1), ROCK1(4), SMPD1(1), TP53(10), TPX2(1) 45034795 85 73 83 18 8 8 9 43 17 0 0.161 1.000 1.000 461 HSA00252_ALANINE_AND_ASPARTATE_METABOLISM Genes involved in alanine and aspartate metabolism AARS, AARS2, ABAT, ACY3, ADSL, ADSS, ADSSL1, AGXT, AGXT2, ASL, ASNS, ASPA, ASRGL1, ASS1, CAD, CRAT, DARS, DARS2, DDO, DLAT, DLD, GAD1, GAD2, GOT1, GOT2, GPT, GPT2, NARS, NARS2, PC, PDHA1, PDHA2, PDHB 33 AARS(1), AARS2(1), ABAT(1), ADSL(1), ADSSL1(1), AGXT(1), AGXT2(1), ASL(1), ASNS(1), ASPA(1), ASS1(2), CAD(4), CRAT(1), DARS(1), DLAT(2), DLD(2), GAD2(1), GOT1(2), GOT2(2), GPT(1), GPT2(1), NARS2(4), PC(1), PDHA1(1), PDHA2(1), PDHB(1) 23391226 37 31 37 10 2 2 9 12 12 0 0.486 1.000 1.000 462 ECMPATHWAY Extracellular matrix induces integrin-mediated FAK phosphorylation in epithelial cells, leading to PI3 and MAP kinase activation and actin reorganization. ARHA, ARHGAP5, DIAPH1, FYN, GSN, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, MYL2, MYLK, PFN1, PIK3CA, PIK3R1, PTK2, PXN, RAF1, ROCK1, SHC1, SRC, TLN1 22 ARHGAP5(4), DIAPH1(1), FYN(1), GSN(1), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), MYL2(1), MYLK(4), PIK3CA(12), PIK3R1(2), PTK2(1), ROCK1(4), SHC1(2), SRC(2), TLN1(4) 23047889 47 46 44 13 4 12 4 19 8 0 0.457 1.000 1.000 463 BLOOD_CLOTTING_CASCADE F10, F11, F12, F13B, F2, F5, F7, F8, F8A1, F9, FGA, FGB, FGG, LPA, PLG, PLAT, PLAU, PLG, SERPINB2, SERPINE1, SERPINF2, VWF 20 F11(1), F12(3), F13B(2), F2(3), F5(4), F7(1), F8(3), F9(1), FGA(1), FGG(1), LPA(2), PLAT(2), PLAU(4), PLG(5), SERPINF2(2), VWF(5) 21610381 40 40 40 12 2 3 8 19 8 0 0.551 1.000 1.000 464 ST_P38_MAPK_PATHWAY p38 is a MAP kinase regulated by cytokines and cellular stress. AKT1, ATF1, CDC42, CREB1, CREB3, CREB5, DUSP1, DUSP10, EEF2K, EIF4E, ELK1, GADD45A, HSPB1, IL1R1, MAP2K3, MAP2K4, MAP2K6, MAP3K10, MAP3K4, MAP3K5, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPKAPK2, MAPKAPK5, MKNK1, MKNK2, MYEF2, NFKB1, NR2C2, SRF, TRAF6 35 AKT1(2), ATF1(2), CDC42(1), DUSP10(1), EIF4E(1), ELK1(1), IL1R1(1), MAP2K3(3), MAP2K6(1), MAP3K10(3), MAP3K4(5), MAP3K5(5), MAP3K7(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPKAPK5(1), MKNK1(1), MKNK2(1), NFKB1(1), NR2C2(1), SRF(1), TRAF6(1) 20630113 37 34 37 10 2 6 0 23 6 0 0.519 1.000 1.000 465 GPCRDB_OTHER ADORA3, ALG6, C5R1, CCKBR, CCR2, CCR3, CCR5, CELSR1, CELSR2, CELSR3, CHRM2, CHRM3, CIDEB, CXCR3, DRD4, EBI2, EDG1, EDNRA, ELA3A, EMR2, EMR3, F2R, FSHR, FY, GHRHR, GNRHR, GPR, GPR116, GPR132, GPR133, GPR135, GPR143, GPR145, GPR17, GPR18, GPR55, GPR56, GPR61, GPR73L1, GPR77, GPR84, GPR88, GRCA, GRM1, GRPR, HRH4, IL8RA, IL8RB, LGR6, LGR7, LPHN2, LPHN3, LTB4R2, MASS1, NTSR1, OR2A9P, OR2M4, OR5E1P, OR7E19P, OR7E47P, OR7E37P, OR7E18P, OR7E35P, LOC441453, OR8G1, LOC442754, OR8G2, P2RY11, P2RY13, PTGFR, RLN3R1, SMO, SSTR2, TAAR5, TSHR, VN1R1 51 ALG6(1), CCKBR(2), CELSR1(7), CELSR2(4), CELSR3(4), CHRM2(2), CHRM3(2), CIDEB(1), EMR2(2), EMR3(5), GPR116(3), GPR133(2), GPR17(1), GPR61(1), GPR77(1), GPR84(2), GRM1(4), HRH4(1), LGR6(2), LPHN2(2), LPHN3(7), NTSR1(1), OR8G1(2), OR8G2(2), P2RY11(1), P2RY13(1), PTGFR(2), SMO(3) 39661521 68 58 68 16 9 14 6 30 9 0 0.0913 1.000 1.000 466 GHPATHWAY Growth hormone receptors dimerize on ligand binding and activate the JAK2 protein kinase. GH1, GHR, GRB2, HRAS, INS, INSR, IRS1, JAK2, MAP2K1, MAPK1, MAPK3, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTPN6, RAF1, RPS6KA1, SHC1, SLC2A4, SOCS1, SOS1, SRF, STAT5A, STAT5B, TCF1 24 GHR(1), GRB2(1), HRAS(1), INSR(3), IRS1(3), JAK2(5), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN6(3), RPS6KA1(2), SHC1(2), SLC2A4(1), SOS1(6), SRF(1), STAT5B(1) 20117940 45 42 42 13 4 11 7 20 3 0 0.340 1.000 1.000 467 HSA04662_B_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in B cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, BLNK, BTK, CARD11, CD19, CD22, CD72, CD79A, CD79B, CD81, CHP, CHUK, CR2, FCGR2B, FOS, GSK3B, HRAS, IFITM1, IKBKB, IKBKG, INPP5D, JUN, KRAS, LILRB3, LYN, MALT1, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCB1, PTPN6, RAC1, RAC2, RAC3, RASGRP3, SYK, VAV1, VAV2, VAV3 62 AKT1(2), AKT2(3), AKT3(2), BCL10(1), BTK(1), CARD11(4), CD19(1), CD22(1), CHUK(1), CR2(1), HRAS(1), INPP5D(1), JUN(2), KRAS(1), LILRB3(3), MALT1(2), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIB(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTPN6(3), RAC1(1), RAC3(1), RASGRP3(1), SYK(1), VAV1(2), VAV2(4) 45555185 84 78 79 20 2 19 10 42 11 0 0.198 1.000 1.000 468 INTRINSICPATHWAY The intrinsic prothrombin activation pathway is activated by traumatized blood vessels and induces clot formation. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, F10, F11, F12, F2, F2R, F5, F8, F9, FGA, FGB, FGG, KLKB1, KNG, PROC, PROS1, SERPINC1, SERPING1 22 COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), F11(1), F12(3), F2(3), F5(4), F8(3), F9(1), FGA(1), FGG(1), KLKB1(1), PROC(4), PROS1(4), SERPING1(2) 27873892 46 43 46 14 4 12 3 19 8 0 0.478 1.000 1.000 469 HSA00051_FRUCTOSE_AND_MANNOSE_METABOLISM Genes involved in fructose and mannose metabolism AKR1B1, AKR1B10, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, FUK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, HSD3B7, KHK, LHPP, MPI, MTMR1, MTMR2, MTMR6, PFKFB1, PFKFB2, PFKFB3, PFKFB4, PFKL, PFKM, PFKP, PGM2, PHPT1, PMM1, PMM2, RDH11, RDH12, RDH13, RDH14, SORD, TPI1, TSTA3, UGCGL1, UGCGL2 40 AKR1B1(2), AKR1B10(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), FUK(1), GMPPB(1), HK1(4), KHK(4), MPI(1), MTMR1(1), MTMR2(1), PFKFB3(1), PFKL(1), PFKM(2), PGM2(2), PMM1(1), RDH11(3), SORD(2), TPI1(1) 23117498 37 36 37 11 5 3 6 14 9 0 0.569 1.000 1.000 470 HSA00052_GALACTOSE_METABOLISM Genes involved in galactose metabolism AKR1B1, AKR1B10, B4GALT1, B4GALT2, G6PC, G6PC2, GAA, GALE, GALK1, GALK2, GALT, GANC, GCK, GLA, GLB1, HK1, HK2, HK3, HSD3B7, LALBA, LCT, MGAM, PFKL, PFKM, PFKP, PGM1, PGM3, RDH11, RDH12, RDH13, RDH14, UGP2 32 AKR1B1(2), AKR1B10(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GANC(1), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(2), PFKL(1), PFKM(2), RDH11(3), UGP2(1) 23600941 33 30 33 10 3 3 6 14 7 0 0.595 1.000 1.000 471 HSA00620_PYRUVATE_METABOLISM Genes involved in pyruvate metabolism ACACA, ACACB, ACAT1, ACAT2, ACOT12, ACSS1, ACSS2, ACYP1, ACYP2, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PCK2, PDHA1, PDHA2, PDHB, PKLR, PKM2 42 ACACA(4), ACACB(3), ACSS1(3), ACSS2(3), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PCK2(1), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1) 28772098 47 43 47 13 0 7 10 15 15 0 0.532 1.000 1.000 472 HSA00561_GLYCEROLIPID_METABOLISM Genes involved in glycerolipid metabolism ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AGK, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AKR1A1, AKR1B1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, CEL, DAK, DGAT1, DGAT2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, GK, GK2, GLA, GLB1, GPAM, LCT, LIPA, LIPC, LIPF, LIPG, LPL, LYCAT, MGLL, PNLIP, PNLIPRP1, PNLIPRP2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, UGCGL1, UGCGL2 55 ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AGK(5), AGPAT6(1), AKR1B1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), DAK(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GK2(1), GLB1(4), GPAM(1), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PNPLA3(2), PPAP2B(1), PPAP2C(2) 36385524 50 46 49 13 5 8 8 19 10 0 0.372 1.000 1.000 473 HSA00310_LYSINE_DEGRADATION Genes involved in lysine degradation AADAT, AASDHPPT, AASS, ACAT1, ACAT2, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, BBOX1, DLST, DOT1L, ECHS1, EHHADH, EHMT1, EHMT2, GCDH, HADH, HADHA, HSD17B10, HSD17B4, HSD3B7, NSD1, OGDH, OGDHL, PIPOX, PLOD1, PLOD2, PLOD3, RDH11, RDH12, RDH13, RDH14, SETD1A, SETD7, SETDB1, SHMT1, SHMT2, SPCS1, SPCS3, SUV39H1, SUV39H2, TMLHE 47 AASDHPPT(2), AASS(4), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BBOX1(2), DOT1L(2), ECHS1(2), EHHADH(2), EHMT1(1), EHMT2(3), HADH(1), HADHA(1), HSD17B4(1), NSD1(4), OGDH(3), OGDHL(2), PIPOX(1), PLOD1(1), PLOD2(4), PLOD3(2), RDH11(3), SETD1A(2), SETDB1(4), SHMT1(2), SHMT2(3), SPCS1(1), SUV39H2(3), TMLHE(1) 34935687 65 59 65 18 6 14 9 23 13 0 0.319 1.000 1.000 474 TCRPATHWAY T cell receptors bind to foreign peptides presented by MHC molecules and induce T cell activation. CALM1, CALM2, CALM3, CD3D, CD3E, CD3G, CD3Z, ELK1, FOS, FYN, GRB2, HRAS, JUN, LAT, LCK, MAP2K1, MAP2K4, MAP3K1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PIK3CA, PIK3R1, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, PTPN7, RAC1, RAF1, RASA1, RELA, SHC1, SOS1, SYT1, TRA@, TRB@, VAV1, ZAP70 42 CALM2(1), CD3E(2), CD3G(1), ELK1(1), FYN(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), PIK3CA(12), PIK3R1(2), PPP3CA(1), PPP3CC(1), PTPN7(1), RAC1(1), RASA1(3), RELA(1), SHC1(2), SOS1(6), SYT1(1), VAV1(2) 28912835 57 53 54 16 5 16 7 23 6 0 0.348 1.000 1.000 475 HSA00010_GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ACSS1, ACSS2, ACYP1, ACYP2, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH7A1, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, G6PC2, GALM, GAPDH, GAPDHS, GCK, GPI, HK1, HK2, HK3, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGAM4, PGK1, PGK2, PGM1, PGM3, PKLR, PKM2, TPI1 64 ACSS1(3), ACSS2(3), ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDH7A1(1), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GALM(2), GAPDHS(1), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TPI1(1) 35889358 59 52 58 16 4 5 7 25 18 0 0.599 1.000 1.000 476 HSA04612_ANTIGEN_PROCESSING_AND_PRESENTATION Genes involved in antigen processing and presentation B2M, CALR, CANX, CD4, CD74, CD8A, CD8B, CIITA, CREB1, CTSB, CTSL1, CTSS, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, HSP90AA1, HSP90AB1, HSPA5, IFI30, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5, KIR3DL1, KIR3DL2, KIR3DL3, KLRC1, KLRC2, KLRC3, KLRC4, KLRD1, LGMN, LTA, NFYA, NFYB, NFYC, PDIA3, PSME1, PSME2, RFX5, RFXANK, RFXAP, TAP1, TAP2, TAPBP 73 B2M(2), CALR(1), CANX(1), CD4(2), CD74(1), CIITA(2), CTSB(3), CTSL1(2), CTSS(1), HLA-C(2), HLA-DPA1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB5(2), HLA-E(2), HLA-F(1), HSP90AA1(4), HSP90AB1(3), HSPA5(2), IFI30(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), KIR2DS4(1), KIR3DL1(1), KIR3DL3(1), KLRC1(2), KLRC2(4), LTA(1), RFX5(1) 25594534 55 50 54 17 4 8 7 27 9 0 0.756 1.000 1.000 477 ST_DICTYOSTELIUM_DISCOIDEUM_CAMP_CHEMOTAXIS_PATHWAY The fungus Dictyostelium discoideum is a model system for cytoskeletal organization during chemotaxis. ACTR2, ACTR3, AKT1, ANGPTL2, BF, DAG1, DGKA, ETFA, GCA, ITGA9, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, MAP2K1, MAPK1, MAPK3, NR1I3, PAK1, PDE3A, PDE3B, PI3, PIK3C2G, PIK3CA, PIK3CD, PIK3R1, PLDN, PSME1, RIPK3, RPS4X, SGCB, VASP 32 ACTR2(1), AKT1(2), GCA(1), ITGA9(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), MAPK3(1), NR1I3(1), PAK1(1), PDE3A(4), PDE3B(1), PIK3C2G(2), PIK3CA(12), PIK3R1(2) 30345000 44 39 41 12 4 11 5 19 5 0 0.239 1.000 1.000 478 RHOPATHWAY RhoA is a G protein whose active form stabilizes actin structures such as focal adhesions and activates Rock1, which phosphorylates myosin light chains. ACTR2, ACTR3, ARHA, ARHGAP1, ARHGAP4, ARHGAP5, ARHGAP6, ARHGEF1, ARHGEF11, ARHGEF5, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, BAIAP2, CFL1, DIAPH1, GSN, LIMK1, MYL2, MYLK, OPHN1, PFN1, PIP5K1A, PIP5K1B, PPP1R12B, ROCK1, SRC, TLN1, VCL 30 ACTR2(1), ARHGAP1(1), ARHGAP5(4), ARHGAP6(1), ARHGEF1(1), ARHGEF11(3), ARHGEF5(1), ARPC1B(1), ARPC2(1), CFL1(1), DIAPH1(1), GSN(1), MYL2(1), MYLK(4), OPHN1(1), PIP5K1A(2), ROCK1(4), SRC(2), TLN1(4), VCL(2) 28107592 37 36 37 10 1 6 2 19 9 0 0.578 1.000 1.000 479 HSA04510_FOCAL_ADHESION Genes involved in focal adhesion ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, ARHGAP5, BAD, BCAR1, BCL2, BIRC2, BIRC3, BIRC4, BRAF, CAPN2, CAV1, CAV2, CAV3, CCND1, CCND2, CCND3, CDC42, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, CRK, CRKL, CTNNB1, DIAPH1, DOCK1, EGF, EGFR, ELK1, ERBB2, FARP2, FIGF, FLNA, FLNB, FLNC, FLT1, FN1, FYN, GRB2, GRLF1, GSK3B, HGF, HRAS, IBSP, IGF1, IGF1R, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, JUN, KDR, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LOC653852, MAP2K1, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MET, MLCK, MRCL3, MRLC2, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PARVA, PARVB, PARVG, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PDPK1, PGF, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP5K1C, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PRKCA, PRKCB1, PRKCG, PTEN, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF1, RELN, RHOA, ROCK1, ROCK2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SPP1, SRC, THBS1, THBS2, THBS3, THBS4, TLN1, TLN2, TNC, TNN, TNR, TNXB, VASP, VAV1, VAV2, VAV3, VCL, VEGFA, VEGFB, VEGFC, VTN, VWF, ZYX 192 ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), ARHGAP5(4), BCAR1(3), BIRC2(3), BIRC3(2), BRAF(1), CCND2(1), CDC42(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(9), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(11), CTNNB1(1), DIAPH1(1), DOCK1(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), FARP2(2), FIGF(2), FLNA(3), FLNB(2), FLNC(4), FLT1(4), FN1(4), FYN(1), GRB2(1), GRLF1(6), HGF(1), HRAS(1), IBSP(1), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), JUN(2), KDR(5), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(3), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), MAPK10(1), MAPK3(1), MAPK9(2), MET(3), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PARVG(1), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PGF(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP5K1C(2), PPP1R12A(1), PRKCG(1), PTEN(20), PTK2(1), RAC1(1), RAC3(1), RAP1A(1), RAPGEF1(2), RELN(3), ROCK1(4), ROCK2(3), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SPP1(2), SRC(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TLN1(4), TLN2(6), TNC(4), TNN(3), TNR(8), TNXB(1), VAV1(2), VAV2(4), VCL(2), VTN(1), VWF(5), ZYX(1) 227635775 415 246 410 139 39 65 49 177 84 1 0.823 1.000 1.000 480 HSA04010_MAPK_SIGNALING_PATHWAY Genes involved in MAPK signaling pathway ACVR1B, ACVR1C, AKT1, AKT2, AKT3, ARRB1, ARRB2, ATF2, ATF4, BDNF, BRAF, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CACNA2D1, CACNA2D2, CACNA2D3, CACNA2D4, CACNB1, CACNB2, CACNB3, CACNB4, CACNG1, CACNG2, CACNG3, CACNG4, CACNG5, CACNG6, CACNG7, CACNG8, CASP3, CD14, CDC25B, CDC42, CHP, CHUK, CRK, CRKL, DAXX, DDIT3, DUSP1, DUSP10, DUSP14, DUSP16, DUSP2, DUSP3, DUSP4, DUSP5, DUSP6, DUSP7, DUSP8, DUSP9, ECSIT, EGF, EGFR, ELK1, ELK4, EVI1, FAS, FASLG, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLNA, FLNB, FLNC, FOS, GADD45A, GADD45B, GADD45G, GNA12, GNG12, GRB2, HRAS, IKBKB, IKBKG, IL1A, IL1B, IL1R1, IL1R2, JUN, JUND, KRAS, LOC653852, MAP2K1, MAP2K1IP1, MAP2K2, MAP2K3, MAP2K4, MAP2K5, MAP2K6, MAP2K7, MAP3K1, MAP3K10, MAP3K12, MAP3K13, MAP3K14, MAP3K2, MAP3K3, MAP3K4, MAP3K5, MAP3K6, MAP3K7, MAP3K7IP1, MAP3K7IP2, MAP3K8, MAP4K1, MAP4K2, MAP4K3, MAP4K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MAPKAPK2, MAPKAPK3, MAPKAPK5, MAPT, MAX, MEF2C, MKNK1, MKNK2, MOS, MRAS, MYC, NF1, NFATC2, NFATC4, NFKB1, NFKB2, NGFB, NLK, NR4A1, NRAS, NTF3, NTF5, NTRK1, NTRK2, PAK1, PAK2, PDGFA, PDGFB, PDGFRA, PDGFRB, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PPM1A, PPM1B, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PPP5C, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTPN5, PTPN7, PTPRR, RAC1, RAC2, RAC3, RAF1, RAP1A, RAP1B, RAPGEF2, RASA1, RASA2, RASGRF1, RASGRF2, RASGRP1, RASGRP2, RASGRP3, RASGRP4, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KA5, RPS6KA6, RRAS, RRAS2, SOS1, SOS2, SRF, STK3, STK4, STMN1, TAOK1, TAOK2, TAOK3, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF1A, TP53, TRAF2, TRAF6, ZAK 246 ACVR1B(4), ACVR1C(1), AKT1(2), AKT2(3), AKT3(2), ATF2(1), ATF4(1), BRAF(1), CACNA1A(5), CACNA1B(3), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(6), CACNA1H(3), CACNA1I(4), CACNA1S(7), CACNA2D1(3), CACNA2D2(1), CACNA2D4(3), CACNB1(1), CACNB2(1), CACNG3(2), CACNG5(2), CACNG6(1), CACNG7(1), CDC42(1), CHUK(1), DAXX(4), DUSP10(1), DUSP3(1), DUSP4(1), DUSP5(2), DUSP8(1), DUSP9(1), ECSIT(2), EGF(4), EGFR(7), ELK1(1), ELK4(1), FAS(1), FASLG(1), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(4), FGFR4(3), FLNA(3), FLNB(2), FLNC(4), GNG12(1), GRB2(1), HRAS(1), IL1R1(1), JUN(2), KRAS(1), MAP2K3(3), MAP2K5(2), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K10(3), MAP3K12(3), MAP3K13(1), MAP3K14(1), MAP3K2(2), MAP3K4(5), MAP3K5(5), MAP3K6(2), MAP3K7(1), MAP4K1(1), MAP4K2(1), MAP4K3(4), MAP4K4(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MAPKAPK5(1), MAPT(1), MAX(3), MKNK1(1), MKNK2(1), MRAS(1), MYC(1), NF1(7), NFATC2(1), NFATC4(3), NFKB1(1), NTRK1(4), PAK1(1), PDGFRA(7), PDGFRB(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PPM1B(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PPP5C(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTPN5(2), PTPN7(1), PTPRR(3), RAC1(1), RAC3(1), RAP1A(1), RAPGEF2(6), RASA1(3), RASA2(1), RASGRF1(3), RASGRF2(2), RASGRP2(2), RASGRP3(1), RASGRP4(2), RPS6KA1(2), RPS6KA6(1), SOS1(6), SOS2(1), SRF(1), TAOK2(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF1A(1), TP53(10), TRAF6(1), ZAK(1) 178314331 306 215 303 84 29 40 37 143 57 0 0.307 1.000 1.000 481 HSA04020_CALCIUM_SIGNALING_PATHWAY Genes involved in calcium signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY7, ADCY8, ADCY9, ADORA2A, ADORA2B, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, AGTR1, ATP2A1, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, ATP2B4, AVPR1A, AVPR1B, BDKRB1, BDKRB2, BST1, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1F, CACNA1G, CACNA1H, CACNA1I, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CCKAR, CCKBR, CD38, CHP, CHRM1, CHRM2, CHRM3, CHRM5, CHRNA7, CYSLTR1, CYSLTR2, DRD1, EDNRA, EDNRB, EGFR, ERBB2, ERBB3, ERBB4, F2R, GNA11, GNA14, GNA15, GNAL, GNAQ, GNAS, GRIN1, GRIN2A, GRIN2C, GRIN2D, GRM1, GRM5, GRPR, HRH1, HRH2, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, LHCGR, LTB4R2, MLCK, MYLK, MYLK2, NOS1, NOS2A, NOS3, NTSR1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, PDE1A, PDE1B, PDE1C, PDGFRA, PDGFRB, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PLN, PPID, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PTAFR, PTGER1, PTGER3, PTGFR, PTK2B, RYR1, RYR2, RYR3, SLC25A4, SLC25A5, SLC25A6, SLC8A1, SLC8A2, SLC8A3, SPHK1, SPHK2, TACR1, TACR2, TACR3, TBXA2R, TNNC1, TNNC2, TRHR, TRPC1, VDAC1, VDAC2, VDAC3 168 ADCY1(1), ADCY2(3), ADCY3(3), ADCY8(6), ADCY9(3), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), ATP2A1(6), ATP2A2(4), ATP2B1(1), ATP2B3(1), ATP2B4(1), AVPR1A(1), BDKRB1(1), BDKRB2(1), CACNA1A(5), CACNA1B(3), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1F(3), CACNA1G(6), CACNA1H(3), CACNA1I(4), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CCKAR(2), CCKBR(2), CD38(1), CHRM2(2), CHRM3(2), CHRM5(2), CHRNA7(1), CYSLTR1(1), DRD1(1), EDNRB(1), EGFR(7), ERBB2(4), ERBB3(3), ERBB4(6), GNA15(1), GNAS(4), GRIN1(2), GRIN2A(4), GRM1(4), GRM5(4), HRH2(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), MYLK(4), MYLK2(1), NOS1(8), NOS3(2), NTSR1(1), P2RX1(2), P2RX2(3), P2RX3(1), PDE1A(1), PDE1B(2), PDE1C(1), PDGFRA(7), PDGFRB(1), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD4(3), PLCE1(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PTAFR(1), PTGFR(2), PTK2B(2), RYR1(11), RYR2(9), RYR3(10), SLC25A4(2), SLC25A5(1), SLC25A6(1), SLC8A1(1), SLC8A2(2), SLC8A3(3), SPHK2(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), TRHR(2), TRPC1(1) 167992818 292 215 290 88 43 37 27 139 46 0 0.383 1.000 1.000 482 HSA04810_REGULATION_OF_ACTIN_CYTOSKELETON Genes involved in regulation of actin cytoskeleton ABI2, ACTN1, ACTN2, ACTN3, ACTN4, APC, APC2, ARAF, ARHGEF1, ARHGEF12, ARHGEF4, ARHGEF6, ARHGEF7, ARPC1A, ARPC1B, ARPC2, ARPC3, ARPC4, ARPC5, ARPC5L, BAIAP2, BCAR1, BDKRB1, BDKRB2, BRAF, C3orf10, CD14, CDC42, CFL1, CFL2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CRK, CRKL, CSK, CYFIP1, CYFIP2, DIAPH1, DIAPH2, DIAPH3, DOCK1, EGF, EGFR, EZR, F2, F2R, FGD1, FGD3, FGF1, FGF10, FGF11, FGF12, FGF13, FGF14, FGF16, FGF17, FGF18, FGF19, FGF2, FGF20, FGF21, FGF22, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FN1, GIT1, GNA12, GNA13, GNG12, GRLF1, GSN, HRAS, INS, IQGAP1, IQGAP2, IQGAP3, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, KRAS, LIMK1, LIMK2, LOC200025, LOC645126, LOC653888, MAP2K1, MAP2K2, MAPK1, MAPK3, MLCK, MOS, MRAS, MRCL3, MRLC2, MSN, MYH10, MYH14, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLK, MYLK2, MYLPF, NCKAP1, NCKAP1L, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDGFA, PDGFB, PDGFRA, PDGFRB, PFN1, PFN2, PFN3, PFN4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R12B, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, RDX, RHOA, ROCK1, ROCK2, RRAS, RRAS2, SCIN, SLC9A1, SOS1, SOS2, SSH1, SSH2, SSH3, TIAM1, TIAM2, TMSB4X, TMSB4Y, TMSL3, VAV1, VAV2, VAV3, VCL, WAS, WASF1, WASF2, WASL 203 ABI2(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), APC(6), APC2(4), ARHGEF1(1), ARHGEF6(1), ARHGEF7(3), ARPC1B(1), ARPC2(1), ARPC5L(1), BCAR1(3), BDKRB1(1), BDKRB2(1), BRAF(1), C3orf10(2), CDC42(1), CFL1(1), CHRM2(2), CHRM3(2), CHRM5(2), CSK(2), CYFIP1(4), CYFIP2(5), DIAPH1(1), DIAPH2(2), DIAPH3(3), DOCK1(1), EGF(4), EGFR(7), F2(3), FGD1(3), FGF13(1), FGF14(1), FGF19(1), FGF2(1), FGF20(1), FGF3(1), FGF6(1), FGF7(1), FGFR1(4), FGFR2(3), FGFR3(4), FGFR4(3), FN1(4), GIT1(2), GNA13(4), GNG12(1), GRLF1(6), GSN(1), HRAS(1), IQGAP1(5), IQGAP2(3), IQGAP3(3), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), KRAS(1), LIMK2(2), MAPK3(1), MRAS(1), MSN(2), MYH14(3), MYH9(2), MYL2(1), MYL7(1), MYL9(1), MYLK(4), MYLK2(1), NCKAP1(1), NCKAP1L(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDGFRA(7), PDGFRB(1), PFN2(1), PFN4(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PPP1R12A(1), PTK2(1), RAC1(1), RAC3(1), RDX(1), ROCK1(4), ROCK2(3), SCIN(1), SLC9A1(2), SOS1(6), SOS2(1), SSH1(2), SSH2(5), SSH3(1), TIAM1(2), TIAM2(1), VAV1(2), VAV2(4), VCL(2), WASF2(1), WASL(6) 172722076 291 202 284 82 21 43 40 136 51 0 0.368 1.000 1.000 483 HSA01430_CELL_COMMUNICATION Genes involved in cell communication ACTB, ACTG1, CHAD, COL11A1, COL11A2, COL17A1, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, COMP, DES, DSC1, DSC2, DSC3, DSG1, DSG2, DSG3, DSG4, FN1, GJA1, GJA10, GJA3, GJA4, GJA5, GJA8, GJA9, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GJB7, GJC1, GJC2, GJC3, GJD2, GJD3, GJD4, IBSP, INA, ITGA6, ITGB4, KRT1, KRT10, KRT12, KRT13, KRT14, KRT15, KRT16, KRT17, KRT18, KRT19, KRT2, KRT20, KRT23, KRT24, KRT25, KRT27, KRT28, KRT3, KRT31, KRT32, KRT33A, KRT33B, KRT34, KRT35, KRT36, KRT37, KRT38, KRT39, KRT4, KRT40, KRT5, KRT6A, KRT6B, KRT6C, KRT7, KRT71, KRT72, KRT73, KRT74, KRT75, KRT76, KRT77, KRT78, KRT79, KRT8, KRT81, KRT82, KRT83, KRT84, KRT85, KRT86, KRT9, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, LMNA, LMNB1, LMNB2, LOC728760, NES, PRPH, RELN, SPP1, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VIM, VTN, VWF 136 ACTG1(2), CHAD(2), COL11A1(9), COL11A2(2), COL17A1(3), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(9), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(11), DSC2(3), DSG1(3), DSG2(2), DSG3(1), DSG4(1), FN1(4), GJA10(1), GJA3(1), GJA4(1), GJA5(3), GJA8(2), GJA9(1), GJB1(1), GJB3(1), GJB6(2), GJC1(1), GJC2(1), GJD2(1), IBSP(1), ITGA6(4), ITGB4(1), KRT1(1), KRT10(1), KRT12(2), KRT13(3), KRT15(2), KRT16(1), KRT17(1), KRT19(1), KRT2(3), KRT23(1), KRT24(1), KRT27(1), KRT28(1), KRT3(1), KRT31(1), KRT35(1), KRT36(2), KRT4(2), KRT5(1), KRT6A(1), KRT6B(1), KRT6C(1), KRT7(1), KRT71(2), KRT72(1), KRT73(1), KRT74(1), KRT75(3), KRT77(1), KRT78(1), KRT79(2), KRT82(2), KRT83(1), KRT84(1), KRT85(2), KRT86(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(3), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), LMNB1(1), NES(5), PRPH(1), RELN(3), SPP1(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(4), TNN(3), TNR(8), TNXB(1), VTN(1), VWF(5) 150895233 267 193 265 100 30 38 30 110 59 0 0.936 1.000 1.000 484 HSA04512_ECM_RECEPTOR_INTERACTION Genes involved in ECM-receptor interaction AGRN, CD36, CD44, CD47, CHAD, COL11A1, COL11A2, COL1A1, COL1A2, COL2A1, COL3A1, COL4A1, COL4A2, COL4A4, COL4A6, COL5A1, COL5A2, COL5A3, COL6A1, COL6A2, COL6A3, COL6A6, DAG1, FN1, FNDC1, FNDC3A, FNDC4, FNDC5, GP1BA, GP1BB, GP5, GP6, GP9, HMMR, HSPG2, IBSP, ITGA1, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAV, ITGB1, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LAMA1, LAMA2, LAMA3, LAMA4, LAMA5, LAMB1, LAMB2, LAMB3, LAMB4, LAMC1, LAMC2, LAMC3, RELN, SDC1, SDC2, SDC3, SDC4, SPP1, SV2A, SV2B, SV2C, THBS1, THBS2, THBS3, THBS4, TNC, TNN, TNR, TNXB, VTN, VWF 85 AGRN(5), CD44(1), CHAD(2), COL11A1(9), COL11A2(2), COL1A1(1), COL1A2(6), COL2A1(5), COL3A1(2), COL4A1(1), COL4A2(1), COL4A4(1), COL4A6(4), COL5A1(3), COL5A2(4), COL5A3(9), COL6A1(2), COL6A2(5), COL6A3(9), COL6A6(11), FN1(4), FNDC1(1), FNDC3A(2), HMMR(1), HSPG2(8), IBSP(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGB1(3), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), LAMA1(7), LAMA2(6), LAMA3(6), LAMA4(5), LAMA5(4), LAMB1(2), LAMB2(3), LAMB4(4), LAMC1(3), LAMC2(5), LAMC3(4), RELN(3), SDC3(1), SPP1(2), SV2C(2), THBS1(6), THBS2(1), THBS3(6), THBS4(3), TNC(4), TNN(3), TNR(8), TNXB(1), VTN(1), VWF(5) 136421267 225 173 225 85 26 32 27 91 49 0 0.939 1.000 1.000 485 HSA04080_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION Genes involved in neuroactive ligand-receptor interaction ADCYAP1R1, ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA2A, ADRA2B, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BRS3, C3AR1, C5AR1, CALCR, CALCRL, CCKAR, CCKBR, CGA, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CNR1, CNR2, CRHR1, CRHR2, CTSG, CYSLTR1, CYSLTR2, DRD1, DRD2, DRD3, DRD4, DRD5, EDG1, EDG2, EDG3, EDG4, EDG5, EDG6, EDG7, EDG8, EDNRA, EDNRB, F2, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHB, FSHR, GABBR1, GABBR2, GABRA1, GABRA2, GABRA3, GABRA4, GABRA5, GABRA6, GABRB1, GABRB2, GABRB3, GABRD, GABRE, GABRG1, GABRG2, GABRG3, GABRP, GABRQ, GABRR1, GABRR2, GALR1, GALR2, GALR3, GCGR, GH1, GH2, GHR, GHRHR, GHSR, GIPR, GLP1R, GLP2R, GLRA1, GLRA2, GLRA3, GLRB, GNRHR, GPR156, GPR23, GPR35, GPR50, GPR63, GPR83, GRIA1, GRIA2, GRIA3, GRIA4, GRID1, GRID2, GRIK1, GRIK2, GRIK3, GRIK4, GRIK5, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRIN3A, GRIN3B, GRM1, GRM2, GRM3, GRM4, GRM5, GRM6, GRM7, GRM8, GRPR, GZMA, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HRH4, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, KISS1R, LEP, LEPR, LHB, LHCGR, LTB4R, LTB4R2, MAS1, MC1R, MC2R, MC3R, MC4R, MC5R, MCHR1, MCHR2, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPBWR1, NPBWR2, NPFFR1, NPFFR2, NPY1R, NPY2R, NPY5R, NR3C1, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, P2RX1, P2RX2, P2RX3, P2RX4, P2RX5, P2RX7, P2RXL1, P2RY1, P2RY10, P2RY11, P2RY13, P2RY14, P2RY2, P2RY4, P2RY5, P2RY6, P2RY8, PARD3, PPYR1, PRL, PRLHR, PRLR, PRSS1, PRSS2, PRSS3, PTAFR, PTGDR, PTGER1, PTGER2, PTGER3, PTGER4, PTGFR, PTGIR, PTH2R, PTHR1, RXFP1, RXFP2, SCTR, SSTR1, SSTR2, SSTR3, SSTR4, SSTR5, TAAR1, TAAR2, TAAR5, TAAR6, TAAR8, TAAR9, TACR1, TACR2, TACR3, TBXA2R, THRA, THRB, TRHR, TRPV1, TSHB, TSHR, TSPO, UTS2R, VIPR1, VIPR2 235 ADCYAP1R1(2), ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CALCR(1), CCKAR(2), CCKBR(2), CHRM2(2), CHRM3(2), CHRM5(2), CNR1(1), CNR2(1), CRHR2(1), CYSLTR1(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2(3), F2RL1(1), F2RL2(1), FPR1(1), GABBR1(1), GABRA1(1), GABRA3(2), GABRA4(2), GABRA5(1), GABRB1(3), GABRB3(1), GABRE(4), GABRG1(2), GABRG2(4), GABRQ(4), GABRR1(2), GALR1(1), GH2(1), GHR(1), GIPR(1), GLP1R(1), GLP2R(2), GLRA2(1), GLRB(1), GPR35(1), GPR50(1), GPR63(1), GPR83(1), GRIA1(4), GRIA2(3), GRIA4(2), GRID1(3), GRID2(4), GRIK1(3), GRIK2(4), GRIK3(2), GRIK5(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRIN3B(2), GRM1(4), GRM2(2), GRM3(2), GRM4(3), GRM5(4), GRM6(1), GRM7(1), GRM8(2), HCRTR2(1), HRH2(1), HRH4(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), LEP(1), LEPR(1), MAS1(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), MCHR2(2), MTNR1B(1), NMBR(1), NMUR2(4), NPBWR1(1), NPBWR2(1), NPFFR2(2), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(2), P2RX1(2), P2RX2(3), P2RX3(1), P2RY10(1), P2RY11(1), P2RY13(1), P2RY14(1), P2RY2(1), P2RY8(2), PARD3(2), PRLR(2), PRSS3(2), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RXFP1(1), SCTR(1), SSTR1(2), SSTR3(1), SSTR4(1), TAAR2(1), TAAR9(1), TACR1(2), TACR2(1), TACR3(2), TBXA2R(1), THRA(2), TRHR(2), VIPR1(1) 133299208 228 172 228 73 35 38 20 103 32 0 0.434 1.000 1.000 486 HSA04530_TIGHT_JUNCTION Genes involved in tight junction ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, AKT1, AKT2, AKT3, AMOTL1, ASH1L, CASK, CDC42, CDK4, CGN, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CRB3, CSDA, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTTN, EPB41, EPB41L1, EPB41L2, EPB41L3, EXOC3, EXOC4, F11R, GNAI1, GNAI2, GNAI3, HCLS1, HRAS, IGSF5, INADL, JAM2, JAM3, KRAS, LLGL1, LLGL2, MAGI1, MAGI2, MAGI3, MLLT4, MPDZ, MPP5, MRAS, MRCL3, MRLC2, MYH1, MYH10, MYH11, MYH13, MYH14, MYH15, MYH2, MYH3, MYH4, MYH6, MYH7, MYH7B, MYH8, MYH9, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NRAS, OCLN, PARD3, PARD6A, PARD6B, PARD6G, PPM1J, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP2R3A, PPP2R3B, PPP2R4, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PTEN, RAB13, RAB3B, RHOA, RRAS, RRAS2, SPTAN1, SRC, SYMPK, TJAP1, TJP1, TJP2, TJP3, VAPA, YES1, ZAK 130 ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), AKT1(2), AKT2(3), AKT3(2), AMOTL1(1), ASH1L(3), CASK(1), CDC42(1), CDK4(1), CGN(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CSDA(3), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), EPB41L1(1), EPB41L2(2), EPB41L3(3), EXOC4(2), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), HCLS1(1), HRAS(1), INADL(3), KRAS(1), LLGL1(3), LLGL2(2), MAGI1(2), MAGI2(3), MAGI3(4), MLLT4(5), MPDZ(4), MPP5(1), MRAS(1), MYH1(4), MYH11(6), MYH13(4), MYH14(3), MYH15(2), MYH2(7), MYH3(5), MYH4(6), MYH6(3), MYH7(2), MYH7B(4), MYH8(1), MYH9(2), MYL2(1), MYL7(1), MYL9(1), PARD3(2), PARD6B(3), PPM1J(2), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP2R3A(1), PPP2R3B(1), PPP2R4(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PTEN(20), SPTAN1(5), SRC(2), TJAP1(1), TJP1(2), TJP2(2), YES1(1), ZAK(1) 120418292 209 158 209 68 20 23 14 86 64 2 0.887 1.000 1.000 487 CALCIUM_REGULATION_IN_CARDIAC_CELLS ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRA1A, ADRA1B, ADRA1D, ADRB1, ADRB2, ADRB3, ANXA6, ARRB1, ARRB2, ATP1A4, ATP1B1, ATP1B2, ATP1B3, ATP2A2, ATP2A3, ATP2B1, ATP2B2, ATP2B3, CACNA1A, CACNA1B, CACNA1C, CACNA1D, CACNA1E, CACNA1S, CACNB1, CACNB3, CALM1, CALM2, CALM3, CALR, CAMK1, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CASQ1, CASQ2, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, FXYD2, GJA1, GJA12, GJA4, GJA5, GJB1, GJB2, GJB3, GJB4, GJB5, GJB6, GNA11, GNAI2, GNAI3, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, ITPR1, ITPR2, ITPR3, KCNB1, KCNJ3, KCNJ5, MGC11266, MYCBP, NME7, PEA15, PKIA, PKIB, PKIG, PLCB3, PLN, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SLC8A3, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 139 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ADRA1A(1), ADRB2(2), ANXA6(1), ATP1A4(3), ATP2A2(4), ATP2B1(1), ATP2B3(1), CACNA1A(5), CACNA1B(3), CACNA1C(8), CACNA1D(4), CACNA1E(2), CACNA1S(7), CACNB1(1), CALM2(1), CALR(1), CAMK1(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CASQ1(2), CASQ2(2), CHRM2(2), CHRM3(2), CHRM5(2), GJA4(1), GJA5(3), GJB1(1), GJB3(1), GJB6(2), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), ITPR1(2), ITPR2(8), ITPR3(3), KCNJ3(3), MYCBP(1), PKIA(1), PLCB3(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RYR1(11), RYR2(9), RYR3(10), SLC8A1(1), SLC8A3(3), USP5(1) 118094932 197 153 197 54 29 23 17 90 38 0 0.269 1.000 1.000 488 HSA04060_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION Genes involved in cytokine-cytokine receptor interaction ACVR1, ACVR1B, ACVR2A, ACVR2B, AMH, AMHR2, BMP2, BMP7, BMPR1A, BMPR1B, BMPR2, CCL1, CCL11, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL2, CCL20, CCL21, CCL22, CCL23, CCL24, CCL25, CCL26, CCL27, CCL28, CCL3, CCL4, CCL5, CCL7, CCL8, CCR1, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CD27, CD40, CD40LG, CD70, CLCF1, CNTF, CNTFR, CRLF2, CSF1, CSF1R, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, CX3CL1, CX3CR1, CXCL1, CXCL10, CXCL11, CXCL12, CXCL13, CXCL14, CXCL16, CXCL2, CXCL3, CXCL5, CXCL6, CXCL9, CXCR3, CXCR4, CXCR6, EDA, EDA2R, EDAR, EGF, EGFR, EPO, EPOR, FAS, FASLG, FLJ78302, FLT1, FLT3, FLT3LG, FLT4, GDF5, GH1, GH2, GHR, HGF, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL15, IL15RA, IL17A, IL17B, IL17RA, IL17RB, IL18, IL18R1, IL18RAP, IL19, IL1A, IL1B, IL1R1, IL1R2, IL1RAP, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL25, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL8, IL8RA, IL8RB, IL9, IL9R, INHBA, INHBB, INHBC, INHBE, KDR, KIT, KITLG, LEP, LEPR, LIF, LIFR, LOC728045, LTA, LTB, LTBR, MET, MPL, NGFR, OSM, OSMR, PDGFB, PDGFC, PDGFRA, PDGFRB, PF4, PF4V1, PLEKHO2, PPBP, PRL, PRLR, RELT, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFRSF11A, TNFRSF11B, TNFRSF12A, TNFRSF13B, TNFRSF13C, TNFRSF14, TNFRSF17, TNFRSF18, TNFRSF19, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF4, TNFRSF6B, TNFRSF8, TNFRSF9, TNFSF10, TNFSF11, TNFSF12, TNFSF13, TNFSF13B, TNFSF14, TNFSF15, TNFSF18, TNFSF4, TNFSF8, TNFSF9, TPO, TSLP, VEGFA, VEGFB, VEGFC, XCL1, XCL2, XCR1 250 ACVR1B(4), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP7(2), BMPR1B(1), BMPR2(4), CCL2(1), CCL27(1), CCL3(1), CCR6(1), CCR9(1), CD27(1), CLCF1(1), CSF1R(5), CSF2RA(3), CSF2RB(1), CSF3R(2), CXCL11(1), CXCR4(1), CXCR6(1), EDA(1), EGF(4), EGFR(7), FAS(1), FASLG(1), FLT1(4), FLT3(2), FLT4(6), GDF5(1), GH2(1), GHR(1), HGF(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL17RA(1), IL17RB(1), IL18R1(1), IL18RAP(3), IL19(2), IL1R1(1), IL1RAP(4), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL25(2), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(2), INHBA(2), INHBB(1), INHBC(1), INHBE(1), KDR(5), KIT(3), KITLG(2), LEP(1), LEPR(1), LIFR(2), LTA(1), LTBR(2), MET(3), NGFR(1), OSMR(1), PDGFC(1), PDGFRA(7), PDGFRB(1), PF4(1), PLEKHO2(1), PRLR(2), RELT(1), TGFB2(2), TGFB3(1), TGFBR2(1), TNFRSF13B(1), TNFRSF17(1), TNFRSF1A(1), TNFRSF4(1), TNFRSF9(1), TNFSF10(1), TNFSF14(1), TNFSF15(1), TNFSF8(1), TNFSF9(1), TPO(3), XCL1(2), XCR1(1) 108952487 186 150 184 46 11 32 23 98 22 0 0.137 1.000 1.000 489 HSA04360_AXON_GUIDANCE Genes involved in axon guidance ABL1, ABLIM1, ABLIM2, ABLIM3, ARHGEF12, CDC42, CDK5, CFL1, CFL2, CHP, CXCL12, CXCR4, DCC, DPYSL2, DPYSL5, EFNA1, EFNA2, EFNA3, EFNA4, EFNA5, EFNB1, EFNB2, EFNB3, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FES, FYN, GNAI1, GNAI2, GNAI3, GSK3B, HRAS, ITGB1, KRAS, L1CAM, LIMK1, LIMK2, LRRC4C, MAPK1, MAPK3, MET, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NGEF, NRAS, NRP1, NTN1, NTN2L, NTN4, NTNG1, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLXNA1, PLXNA2, PLXNA3, PLXNB1, PLXNB2, PLXNB3, PLXNC1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PTK2, RAC1, RAC2, RAC3, RASA1, RGS3, RHOA, RHOD, RND1, ROBO1, ROBO2, ROBO3, ROCK1, ROCK2, SEMA3A, SEMA3B, SEMA3C, SEMA3D, SEMA3E, SEMA3F, SEMA3G, SEMA4A, SEMA4B, SEMA4C, SEMA4D, SEMA4F, SEMA4G, SEMA5A, SEMA5B, SEMA6A, SEMA6B, SEMA6C, SEMA6D, SEMA7A, SLIT1, SLIT2, SLIT3, SRGAP1, SRGAP2, SRGAP3, UNC5A, UNC5B, UNC5C, UNC5D 127 ABL1(4), ABLIM1(3), ABLIM3(2), CDC42(1), CFL1(1), CXCR4(1), DCC(3), DPYSL2(2), EFNA3(1), EPHA1(3), EPHA3(2), EPHA5(3), EPHA6(2), EPHA7(1), EPHA8(5), EPHB1(1), EPHB2(1), EPHB4(2), EPHB6(5), FES(1), FYN(1), GNAI1(1), GNAI2(1), GNAI3(1), HRAS(1), ITGB1(3), KRAS(1), L1CAM(4), LIMK2(2), MAPK3(1), MET(3), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NRP1(1), NTN4(2), NTNG1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PLXNA1(2), PLXNA2(2), PLXNA3(3), PLXNB1(5), PLXNB2(2), PLXNC1(2), PPP3CA(1), PPP3CC(1), PPP3R2(1), PTK2(1), RAC1(1), RAC3(1), RASA1(3), RGS3(5), RND1(3), ROBO1(2), ROBO2(4), ROCK1(4), ROCK2(3), SEMA3A(2), SEMA3B(1), SEMA3C(1), SEMA3D(3), SEMA3E(2), SEMA3F(1), SEMA3G(1), SEMA4A(1), SEMA4B(1), SEMA4C(1), SEMA4D(1), SEMA4F(1), SEMA4G(2), SEMA5A(1), SEMA6C(1), SEMA6D(2), SLIT1(1), SLIT2(3), SLIT3(5), SRGAP1(4), SRGAP2(1), SRGAP3(2), UNC5A(2), UNC5B(2), UNC5C(1), UNC5D(2) 119700033 181 144 179 65 17 27 18 86 33 0 0.918 1.000 1.000 490 SMOOTH_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADM, ADMR, ARRB1, ARRB2, ATF1, ATF2, ATF3, ATF4, ATF5, ATP2A2, ATP2A3, CACNB3, CALCA, CALM1, CALM2, CALM3, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CMKOR1, CNN1, CNN2, CORIN, CREB3, CREBL1, CREBL1, TNXB, CRH, CRHR1, DGKZ, EDG2, ETS2, FOS, GABPA, GABPB2, GBA2, GJA1, GNAQ, GNB1, GNB2, GNB3, GNB4, GNB5, GNG12, GNG13, GNG2, GNG3, GNG4, GNG5, GNG7, GNGT1, GRK4, GRK5, GRK6, GSTO1, GUCA2A, GUCA2B, GUCY1A3, HEAB, IGFBP1, IGFBP2, IGFBP3, IGFBP4, IGFBP6, IL1B, IL6, ITPR1, ITPR2, ITPR3, JUN, LGR7, LGR8, MAFF, MGC11266, MYL2, MYL4, MYLK2, NFKB1, NOS1, NOS3, OXT, OXTR, PDE4B, PDE4D, PKIA, PKIB, PKIG, PLCB3, PLCD1, PLCG1, PLCG2, PRKACA, PRKACB, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCH, PRKCQ, PRKCZ, PRKD1, RAMP1, RAMP2, RAMP3, RCP9, RGS1, RGS10, RGS11, RGS14, RGS16, RGS17, RGS18, RGS19, RGS2, RGS20, RGS3, RGS4, RGS5, RGS6, RGS7, RGS9, RLN1, RYR1, RYR2, RYR3, SARA1, SFN, SLC8A1, SP1, USP5, YWHAB, YWHAH, YWHAQ, YWHAQ, MIB1 137 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ATF1(2), ATF2(1), ATF4(1), ATF5(1), ATP2A2(4), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CNN2(1), CORIN(1), DGKZ(2), GABPA(1), GBA2(4), GNB1(2), GNB5(1), GNG12(1), GNG3(1), GRK5(1), GRK6(3), GSTO1(1), GUCA2A(1), GUCY1A3(2), IGFBP2(1), IGFBP3(1), IGFBP4(1), IGFBP6(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), MYL2(1), MYLK2(1), NFKB1(1), NOS1(8), NOS3(2), PDE4B(2), PDE4D(1), PKIA(1), PLCB3(1), PLCG2(1), PRKACA(1), PRKACB(4), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), RAMP1(1), RAMP3(1), RGS11(1), RGS17(2), RGS18(1), RGS19(1), RGS2(1), RGS3(5), RGS6(2), RGS7(1), RGS9(3), RLN1(1), RYR1(11), RYR2(9), RYR3(10), SLC8A1(1), TNXB(1), USP5(1) 106310346 170 142 170 50 23 24 16 80 27 0 0.545 1.000 1.000 491 HISTONE_METHYLTRANSFERASE Genes with HMT activity AOF2, KDM6A, ASH1L, ASH2L, C17orf79, CARM1, CTCFL, DOT1L, EED, EHMT1, EHMT2, EZH1, EZH2, FBXL10, FBXL11, FBXO11, HCFC1, HSF4, JMJD1A, JMJD1B, JMJD2A, JMJD2B, JMJD2C, JMJD2D, JMJD3, JMJD4, JMJD6, MEN1, MLL, MLL2, MLL3, MLL4, MLL5, NSD1, OGT, PAXIP1, PPP1CA, PPP1CB, PPP1CC, PRDM2, PRDM6, PRDM7, PRDM9, PRMT1, PRMT5, PRMT6, PRMT7, PRMT8, RBBP5, SATB1, SETD1A, SETD1B, SETD2, SETD7, SETD8, SETDB1, SETDB2, SETMAR, SMYD3, STK38, SUV39H1, SUV39H2, SUV420H1, SUV420H2, SUZ12, WHSC1, WHSC1L1 57 ASH1L(3), ASH2L(2), CTCFL(1), DOT1L(2), EHMT1(1), EHMT2(3), EZH1(1), EZH2(3), FBXO11(2), HCFC1(5), HSF4(2), JMJD4(1), JMJD6(4), KDM6A(4), MEN1(1), MLL(5), MLL2(13), MLL3(15), MLL4(3), MLL5(6), NSD1(4), OGT(4), PRDM2(1), PRDM6(1), PRDM7(2), PRDM9(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), RBBP5(3), SETD1A(2), SETD1B(1), SETD2(52), SETDB1(4), SETMAR(1), SUV39H2(3), SUZ12(5), WHSC1(2), WHSC1L1(5) 75331297 173 139 171 38 10 18 22 52 70 1 0.111 1.000 1.000 492 HSA04910_INSULIN_SIGNALING_PATHWAY Genes involved in insulin signaling pathway ACACA, ACACB, AKT1, AKT2, AKT3, ARAF, BAD, BRAF, CALM1, CALM2, CALM3, CALML3, CALML6, CBL, CBLB, CBLC, CRK, CRKL, EIF4EBP1, ELK1, EXOC7, FASN, FBP1, FBP2, FLOT1, FLOT2, FOXO1, FRAP1, G6PC, G6PC2, GCK, GRB2, GSK3B, GYS1, GYS2, HRAS, IKBKB, INPP5D, INS, INSR, IRS1, IRS2, IRS4, KIAA1303, KRAS, LIPE, MAP2K1, MAP2K2, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MKNK1, MKNK2, NRAS, PCK1, PCK2, PDE3A, PDE3B, PDPK1, PFKL, PFKM, PFKP, PHKA1, PHKA2, PHKB, PHKG1, PHKG2, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PKLR, PKM2, PPARGC1A, PPP1CA, PPP1CB, PPP1CC, PPP1R3A, PPP1R3B, PPP1R3C, PPP1R3D, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKACA, PRKACB, PRKACG, PRKAG1, PRKAG2, PRKAG3, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCI, PRKCZ, PRKX, PRKY, PTPN1, PTPRF, PYGB, PYGL, PYGM, RAF1, RAPGEF1, RHEB, RHOQ, RPS6, RPS6KB1, RPS6KB2, SH2B2, SHC1, SHC2, SHC3, SHC4, SKIP, SLC2A4, SOCS1, SOCS2, SOCS3, SOCS4, SORBS1, SOS1, SOS2, SREBF1, TRIP10, TSC1, TSC2 129 ACACA(4), ACACB(3), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CALM2(1), CBL(1), CBLB(2), CBLC(1), ELK1(1), EXOC7(1), FASN(3), FBP1(1), FOXO1(2), G6PC(2), GRB2(1), GYS1(1), GYS2(1), HRAS(1), INPP5D(1), INSR(3), IRS1(3), IRS4(1), KRAS(1), LIPE(4), MAPK10(1), MAPK3(1), MAPK9(2), MKNK1(1), MKNK2(1), PCK1(4), PCK2(1), PDE3A(4), PDE3B(1), PFKL(1), PFKM(2), PHKA1(3), PHKA2(3), PHKB(3), PHKG1(3), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PKM2(1), PPARGC1A(3), PPP1R3A(3), PPP1R3C(1), PPP1R3D(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAG1(1), PRKAG2(4), PRKAR1A(2), PRKAR2B(1), PRKCI(1), PRKCZ(2), PTPN1(1), PTPRF(3), PYGB(2), PYGL(1), PYGM(2), RAPGEF1(2), RHEB(4), RHOQ(1), RPS6KB1(1), RPS6KB2(1), SH2B2(1), SHC1(2), SHC2(1), SHC3(1), SLC2A4(1), SOCS4(1), SORBS1(1), SOS1(6), SOS2(1), SREBF1(2), TRIP10(1), TSC1(2), TSC2(4) 97539146 170 137 164 30 14 29 21 84 22 0 0.00287 1.000 1.000 493 HSA04310_WNT_SIGNALING_PATHWAY Genes involved in Wnt signaling pathway APC, APC2, AXIN1, AXIN2, BTRC, CACYBP, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CCND1, CCND2, CCND3, CER1, CHD8, CHP, CREBBP, CSNK1A1, CSNK1A1L, CSNK1E, CSNK2A1, CSNK2A2, CSNK2B, CTBP1, CTBP2, CTNNB1, CTNNBIP1, CUL1, CXXC4, DAAM1, DAAM2, DKK1, DKK2, DKK4, DVL1, DVL2, DVL3, EP300, FBXW11, FOSL1, FRAT1, FRAT2, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LEF1, LOC652788, LRP5, LRP6, MAP3K7, MAPK10, MAPK8, MAPK9, MMP7, MYC, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NKD1, NKD2, NLK, PLCB1, PLCB2, PLCB3, PLCB4, PORCN, PPARD, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRICKLE1, PRICKLE2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, PSEN1, RAC1, RAC2, RAC3, RBX1, RHOA, ROCK1, ROCK2, RUVBL1, SENP2, SFRP1, SFRP2, SFRP4, SFRP5, SIAH1, SKP1, SMAD2, SMAD3, SMAD4, SOX17, TBL1X, TBL1XR1, TBL1Y, TCF7, TCF7L1, TCF7L2, TP53, VANGL1, VANGL2, WIF1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 144 APC(6), APC2(4), AXIN1(2), AXIN2(1), BTRC(2), CACYBP(2), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CCND2(1), CER1(1), CHD8(2), CREBBP(4), CSNK1A1(1), CSNK2A2(1), CSNK2B(1), CTBP1(1), CTBP2(1), CTNNB1(1), CUL1(3), CXXC4(1), DAAM1(2), DKK2(1), DVL1(1), EP300(6), FBXW11(1), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), JUN(2), LEF1(1), LRP5(2), LRP6(2), MAP3K7(1), MAPK10(1), MAPK9(2), MYC(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NKD1(2), NKD2(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PORCN(1), PPARD(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRICKLE1(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAC1(1), RAC3(1), ROCK1(4), ROCK2(3), SFRP4(2), SMAD2(2), SMAD3(1), SMAD4(1), TBL1X(2), TBL1XR1(3), TCF7L2(1), TP53(10), VANGL1(1), VANGL2(1), WIF1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1) 97713874 167 135 165 54 14 15 27 82 29 0 0.755 1.000 1.000 494 HSA04630_JAK_STAT_SIGNALING_PATHWAY Genes involved in Jak-STAT signaling pathway AKT1, AKT2, AKT3, BCL2L1, CBL, CBLB, CBLC, CCND1, CCND2, CCND3, CISH, CLCF1, CNTF, CNTFR, CREBBP, CRLF2, CSF2, CSF2RA, CSF2RB, CSF3, CSF3R, CTF1, EP300, EPO, EPOR, GH1, GH2, GHR, GRB2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNE1, IFNG, IFNGR1, IFNGR2, IFNK, IFNW1, IL10, IL10RA, IL10RB, IL11, IL11RA, IL12A, IL12B, IL12RB1, IL12RB2, IL13, IL13RA1, IL13RA2, IL15, IL15RA, IL19, IL2, IL20, IL20RA, IL21, IL21R, IL22, IL22RA1, IL22RA2, IL23A, IL23R, IL24, IL26, IL28A, IL28B, IL28RA, IL29, IL2RA, IL2RB, IL2RG, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL6ST, IL7, IL7R, IL9, IL9R, IRF9, JAK1, JAK2, JAK3, LEP, LEPR, LIF, LIFR, MPL, MYC, OSM, OSMR, PIAS1, PIAS2, PIAS3, PIAS4, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIM1, PRL, PRLR, PTPN11, PTPN6, SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS7, SOS1, SOS2, SPRED1, SPRED2, SPRY1, SPRY2, SPRY3, SPRY4, STAM, STAM2, STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B, STAT6, TPO, TSLP, TYK2 150 AKT1(2), AKT2(3), AKT3(2), CBL(1), CBLB(2), CBLC(1), CCND2(1), CLCF1(1), CREBBP(4), CSF2RA(3), CSF2RB(1), CSF3R(2), EP300(6), GH2(1), GHR(1), GRB2(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), IFNK(1), IL12RB1(1), IL12RB2(2), IL13RA1(1), IL15(1), IL15RA(2), IL19(2), IL21(1), IL21R(2), IL22(1), IL22RA1(1), IL23A(1), IL23R(1), IL28A(1), IL28B(1), IL2RA(2), IL2RB(1), IL3(1), IL4(1), IL4R(2), IL6ST(3), IL9R(2), IRF9(2), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), LIFR(2), MYC(1), OSMR(1), PIAS1(2), PIAS2(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PRLR(2), PTPN11(1), PTPN6(3), SOCS4(1), SOS1(6), SOS2(1), SPRED1(5), SPRED2(1), SPRY2(2), SPRY4(2), STAM(2), STAT1(4), STAT2(3), STAT3(1), STAT4(1), STAT5B(1), STAT6(2), TPO(3), TYK2(3) 89448315 167 133 163 46 8 32 27 81 19 0 0.280 1.000 1.000 495 HSA04514_CELL_ADHESION_MOLECULES Genes involved in cell adhesion molecules (CAMs) ALCAM, CADM1, CADM3, CD2, CD22, CD226, CD274, CD276, CD28, CD34, CD4, CD40, CD40LG, CD58, CD6, CD80, CD86, CD8A, CD8B, CD99, CDH1, CDH15, CDH2, CDH3, CDH4, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CNTN1, CNTN2, CNTNAP1, CNTNAP2, CTLA4, ESAM, F11R, GLG1, HLA-A, HLA-A29.1, HLA-B, HLA-C, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA1, HLA-DQA2, HLA-DQB1, HLA-DQB2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, HLA-E, HLA-F, HLA-G, ICAM1, ICAM2, ICAM3, ICOS, ICOSLG, ITGA4, ITGA6, ITGA8, ITGA9, ITGAL, ITGAM, ITGAV, ITGB1, ITGB2, ITGB7, ITGB8, JAM2, JAM3, L1CAM, MADCAM1, MAG, MPZ, MPZL1, NCAM1, NCAM2, NEGR1, NEO1, NFASC, NLGN1, NLGN2, NLGN3, NRCAM, NRXN1, NRXN2, NRXN3, OCLN, PDCD1, PDCD1LG2, PECAM1, PTPRC, PTPRF, PTPRM, PVR, PVRL1, PVRL2, PVRL3, SDC1, SDC2, SDC3, SDC4, SELE, SELL, SELP, SELPLG, SIGLEC1, SPN, VCAM1, VCAN 129 ALCAM(2), CADM3(1), CD22(1), CD28(1), CD34(1), CD4(2), CD6(2), CD86(1), CD99(1), CDH1(2), CDH2(5), CDH3(2), CDH4(4), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CNTN1(2), CNTN2(1), CNTNAP1(5), CNTNAP2(4), ESAM(1), F11R(1), GLG1(4), HLA-C(2), HLA-DPA1(1), HLA-DQB1(2), HLA-DRA(1), HLA-DRB5(2), HLA-E(2), HLA-F(1), ITGA4(1), ITGA6(4), ITGA9(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITGB7(2), ITGB8(1), L1CAM(4), MPZL1(1), NCAM1(1), NCAM2(2), NEGR1(2), NEO1(2), NFASC(4), NRCAM(3), NRXN1(5), NRXN2(4), NRXN3(3), PTPRC(6), PTPRF(3), PTPRM(3), PVRL2(2), PVRL3(2), SDC3(1), SELE(4), SELP(1), SELPLG(1), SIGLEC1(1), SPN(1), VCAM1(1), VCAN(6) 88453477 147 122 147 62 11 21 22 72 21 0 0.971 1.000 1.000 496 HSA00230_PURINE_METABOLISM Genes involved in purine metabolism ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADK, ADSL, ADSS, ADSSL1, AK1, AK2, AK3L1, AK5, AK7, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, FHIT, GART, GDA, GMPR, GMPR2, GMPS, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NPR1, NPR2, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, NUDT5, NUDT9, PAICS, PAPSS1, PAPSS2, PDE10A, PDE11A, PDE1A, PDE1C, PDE2A, PDE3B, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6D, PDE6G, PDE6H, PDE7A, PDE7B, PDE8A, PDE8B, PDE9A, PFAS, PKLR, PKM2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PPAT, PRIM1, PRIM2, PRPS1, PRPS1L1, PRPS2, PRUNE, RFC5, RRM1, RRM2, RRM2B, SAC, XDH, ZNRD1 142 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ADSL(1), ADSSL1(1), AK2(1), AK5(1), AK7(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(2), ATIC(1), CANT1(1), ENPP3(1), ENTPD2(1), GDA(1), GMPR(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), NUDT9(1), PAPSS1(3), PAPSS2(2), PDE10A(1), PDE11A(3), PDE1A(1), PDE1C(1), PDE2A(1), PDE3B(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE8A(2), PDE8B(1), PFAS(1), PKM2(1), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(2), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(3), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RFC5(1), RRM1(2), RRM2(1), XDH(2) 101616272 143 121 142 32 10 20 15 66 32 0 0.151 1.000 1.000 497 HSA04912_GNRH_SIGNALING_PATHWAY Genes involved in GnRH signaling pathway ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ATF4, CACNA1C, CACNA1D, CACNA1F, CACNA1S, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CDC42, CGA, EGFR, ELK1, FSHB, GNA11, GNAQ, GNAS, GNRH1, GNRH2, GNRHR, GRB2, HBEGF, HRAS, ITPR1, ITPR2, ITPR3, JUN, KRAS, LHB, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K2, MAP3K3, MAP3K4, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK7, MAPK8, MAPK9, MMP14, MMP2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PLD1, PLD2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCD, PRKX, PRKY, PTK2B, RAF1, SOS1, SOS2, SRC 95 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), ATF4(1), CACNA1C(8), CACNA1D(4), CACNA1F(3), CACNA1S(7), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CDC42(1), EGFR(7), ELK1(1), GNAS(4), GRB2(1), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), JUN(2), KRAS(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K2(2), MAP3K4(5), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MMP14(1), MMP2(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLD1(2), PLD2(2), PRKACA(1), PRKACB(4), PRKACG(2), PRKCD(2), PTK2B(2), SOS1(6), SOS2(1), SRC(2) 80046947 144 116 143 40 18 20 14 74 18 0 0.347 1.000 1.000 498 HSA04110_CELL_CYCLE Genes involved in cell cycle ABL1, ANAPC1, ANAPC10, ANAPC11, ANAPC2, ANAPC4, ANAPC5, ANAPC7, ATM, ATR, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDC14A, CDC14B, CDC16, CDC2, CDC20, CDC23, CDC25A, CDC25B, CDC25C, CDC26, CDC27, CDC45L, CDC6, CDC7, CDK2, CDK4, CDK6, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CHEK1, CHEK2, CREBBP, CUL1, DBF4, E2F1, E2F2, E2F3, EP300, ESPL1, FZR1, GADD45A, GADD45B, GADD45G, GSK3B, hCG_1982709, HDAC1, HDAC2, LOC440917, LOC728919, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PKMYT1, PLK1, PRKDC, PTTG1, PTTG2, RB1, RBL1, RBL2, RBX1, SFN, SKP1, SKP2, SMAD2, SMAD3, SMAD4, SMC1A, SMC1B, TFDP1, TGFB1, TGFB2, TGFB3, TP53, WEE1, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ, YWHAZ 109 ABL1(4), ANAPC1(4), ANAPC11(1), ANAPC2(1), ANAPC4(1), ANAPC5(1), ANAPC7(2), ATM(15), ATR(5), BUB3(1), CCNA1(3), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDC14A(3), CDC16(2), CDC20(1), CDC23(2), CDC25A(1), CDC25C(2), CDC27(2), CDC7(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CHEK2(1), CREBBP(4), CUL1(3), E2F1(1), EP300(6), ESPL1(7), FZR1(4), HDAC1(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(5), RB1(1), RBL2(2), SKP2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMC1A(2), SMC1B(2), TGFB2(2), TGFB3(1), TP53(10), WEE1(1), YWHAE(1) 85002005 151 114 151 37 9 22 22 65 33 0 0.196 1.000 1.000 499 HSA04520_ADHERENS_JUNCTION Genes involved in adherens junction ACP1, ACTB, ACTG1, ACTN1, ACTN2, ACTN3, ACTN4, ACVR1B, ACVR1C, BAIAP2, CDC42, CDH1, CREBBP, CSNK2A1, CSNK2A2, CSNK2B, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, EGFR, EP300, ERBB2, FARP2, FER, FGFR1, FYN, IGF1R, INSR, IQGAP1, LEF1, LMO7, MAP3K7, MAPK1, MAPK3, MET, MLLT4, NLK, PARD3, PTPN1, PTPN6, PTPRB, PTPRF, PTPRJ, PTPRM, PVRL1, PVRL2, PVRL3, PVRL4, RAC1, RAC2, RAC3, RHOA, SMAD2, SMAD3, SMAD4, SNAI1, SNAI2, SORBS1, SRC, SSX2IP, TCF7, TCF7L1, TCF7L2, TGFBR1, TGFBR2, TJP1, VCL, WAS, WASF1, WASF2, WASF3, WASL, YES1 75 ACP1(1), ACTG1(2), ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ACVR1B(4), ACVR1C(1), CDC42(1), CDH1(2), CREBBP(4), CSNK2A2(1), CSNK2B(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), EGFR(7), EP300(6), ERBB2(4), FARP2(2), FGFR1(4), FYN(1), INSR(3), IQGAP1(5), LEF1(1), LMO7(4), MAP3K7(1), MAPK3(1), MET(3), MLLT4(5), PARD3(2), PTPN1(1), PTPN6(3), PTPRB(3), PTPRF(3), PTPRJ(4), PTPRM(3), PVRL2(2), PVRL3(2), RAC1(1), RAC3(1), SMAD2(2), SMAD3(1), SMAD4(1), SNAI1(1), SNAI2(2), SORBS1(1), SRC(2), SSX2IP(3), TCF7L2(1), TGFBR2(1), TJP1(2), VCL(2), WASF2(1), WASF3(1), WASL(6), YES1(1) 74430827 136 112 135 39 11 15 24 65 21 0 0.505 1.000 1.000 500 HSA04540_GAP_JUNCTION Genes involved in gap junction ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ADRB1, CDC2, CSNK1D, DRD1, DRD2, EDG2, EGF, EGFR, GJA1, GJD2, GNA11, GNAI1, GNAI2, GNAI3, GNAQ, GNAS, GRB2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, HTR2A, HTR2B, HTR2C, ITPR1, ITPR2, ITPR3, KRAS, LOC643224, LOC654264, MAP2K1, MAP2K2, MAP2K5, MAP3K2, MAPK1, MAPK3, MAPK7, NPR1, NPR2, NRAS, PDGFA, PDGFB, PDGFC, PDGFD, PDGFRA, PDGFRB, PLCB1, PLCB2, PLCB3, PLCB4, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, PRKX, PRKY, RAF1, SOS1, SOS2, SRC, TJP1, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8 92 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), DRD1(1), DRD2(1), EGF(4), EGFR(7), GJD2(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAS(4), GRB2(1), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), HTR2A(1), HTR2C(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAP2K5(2), MAP3K2(2), MAPK3(1), NPR1(3), NPR2(2), PDGFC(1), PDGFD(1), PDGFRA(7), PDGFRB(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), PRKG1(2), PRKG2(2), SOS1(6), SOS2(1), SRC(2), TJP1(2), TUBA1A(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1) 81467808 140 112 138 38 15 19 15 68 23 0 0.372 1.000 1.000 501 HSA04670_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION Genes involved in Leukocyte transendothelial migration ACTN1, ACTN2, ACTN3, ACTN4, ARHGAP5, BCAR1, CD99, CDC42, CDH5, CLDN1, CLDN10, CLDN11, CLDN14, CLDN15, CLDN16, CLDN17, CLDN18, CLDN19, CLDN2, CLDN20, CLDN22, CLDN23, CLDN3, CLDN4, CLDN5, CLDN6, CLDN7, CLDN8, CLDN9, CTNNA1, CTNNA2, CTNNA3, CTNNB1, CTNND1, CXCL12, CXCR4, CYBA, CYBB, ESAM, EZR, F11R, GNAI1, GNAI2, GNAI3, GRLF1, ICAM1, ITGA4, ITGAL, ITGAM, ITGB1, ITGB2, ITK, JAM2, JAM3, MAPK11, MAPK12, MAPK13, MAPK14, MLLT4, MMP2, MMP9, MRCL3, MRLC2, MSN, MYL2, MYL5, MYL7, MYL8P, MYL9, MYLC2PL, MYLPF, NCF1, NCF2, NCF4, NOX1, NOX3, OCLN, PECAM1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, PTK2B, PTPN11, PXN, RAC1, RAC2, RAP1A, RAP1B, RAPGEF3, RAPGEF4, RASSF5, RHOA, RHOH, ROCK1, ROCK2, SIPA1, THY1, TXK, VASP, VAV1, VAV2, VAV3, VCAM1, VCL 109 ACTN1(1), ACTN2(3), ACTN3(1), ACTN4(1), ARHGAP5(4), BCAR1(3), CD99(1), CDC42(1), CDH5(1), CLDN10(2), CLDN16(1), CLDN18(1), CLDN2(2), CLDN4(1), CLDN7(1), CLDN9(1), CTNNA1(2), CTNNA2(4), CTNNA3(2), CTNNB1(1), CTNND1(4), CXCR4(1), ESAM(1), F11R(1), GNAI1(1), GNAI2(1), GNAI3(1), GRLF1(6), ITGA4(1), ITGAL(4), ITGAM(3), ITGB1(3), ITGB2(1), ITK(1), MAPK12(1), MAPK13(1), MAPK14(1), MLLT4(5), MMP2(4), MMP9(1), MSN(2), MYL2(1), MYL7(1), MYL9(1), NCF1(1), NCF2(1), NOX1(2), NOX3(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), PTK2B(2), PTPN11(1), RAC1(1), RAP1A(1), RAPGEF3(2), RAPGEF4(1), ROCK1(4), ROCK2(3), VAV1(2), VAV2(4), VCAM1(1), VCL(2) 76843470 137 112 133 48 10 24 15 58 30 0 0.772 1.000 1.000 502 ST_INTEGRIN_SIGNALING_PATHWAY Integrins are transmembrane receptors that mediate cell growth, survival, and migration by binding to ligands in the extracellular matrix. ABL1, ACK1, ACTN1, ACTR2, ACTR3, AKT1, AKT2, AKT3, ANGPTL2, ARHGEF6, ARHGEF7, BCAR1, BRAF, CAV1, CDC42, CDKN2A, CRK, CSE1L, DDEF1, DOCK1, EPHB2, FYN, GRAF, GRB2, GRB7, GRF2, GRLF1, ILK, ITGA1, ITGA10, ITGA11, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGB3BP, MAP2K4, MAP2K7, MAP3K11, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, MRAS, MYLK, MYLK2, P4HB, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PKLR, PLCG1, PLCG2, PTEN, PTK2, RAF1, RALA, RHO, ROCK1, ROCK2, SHC1, SOS1, SOS2, SRC, TERF2IP, TLN1, TLN2, VASP, WAS, ZYX 78 ABL1(4), ACTN1(1), ACTR2(1), AKT1(2), AKT2(3), AKT3(2), ARHGEF6(1), ARHGEF7(3), BCAR1(3), BRAF(1), CDC42(1), CDKN2A(3), CSE1L(2), DOCK1(1), EPHB2(1), FYN(1), GRB2(1), GRB7(2), GRLF1(6), ILK(1), ITGA1(3), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), MAP2K7(1), MAP3K11(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2), MRAS(1), MYLK(4), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CA(12), PIK3CB(1), PLCG2(1), PTEN(20), PTK2(1), RHO(1), ROCK1(4), ROCK2(3), SHC1(2), SOS1(6), SOS2(1), SRC(2), TLN1(4), TLN2(6), ZYX(1) 75577526 147 112 144 38 9 31 15 58 33 1 0.218 1.000 1.000 503 INTEGRIN_MEDIATED_CELL_ADHESION_KEGG AKT1, AKT3, BCAR1, CAPN1, CAPN10, CAPN11, CAPN2, CAPN3, CAPN5, CAPN6, CAPN7, CAPN9, CAPNS1, CAV1, CAV2, CAV3, CDC42, CRK, CSK, DKFZp434E1119, DOCK1, FLJ14825, FLJ40125, FYN, GIT2, GRB2, ILK, ITGA10, ITGA11, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGA7, ITGA8, ITGA9, ITGAD, ITGAE, ITGAL, ITGAM, ITGAV, ITGAX, ITGB1, ITGB2, ITGB3, ITGB4, ITGB5, ITGB6, ITGB7, ITGB8, LOC283874, PDPK1, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAPK10, MAPK12, MAPK4, MAPK6, MAPK7, MGC17301, MYLK2, PAK1, PAK2, PAK3, PAK4, PAK6, PDPK1, PIK3R2, PTK2, PXN, RAC1, RAC2, RAC3, RAP1B, RAPGEF1, RHO, ROCK1, ROCK2, SDCCAG8, SEPP1, SHC1, SHC3, SORBS1, SOS1, SRC, TLN1, TNS, TNS1, VASP, VAV2, VAV3, VCL, ZYX 90 AKT1(2), AKT3(2), BCAR1(3), CAPN1(2), CAPN11(1), CAPN3(3), CAPN5(1), CAPN6(1), CAPN7(1), CAPN9(2), CDC42(1), CSK(2), DOCK1(1), FYN(1), GIT2(1), GRB2(1), ILK(1), ITGA10(2), ITGA11(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGA7(1), ITGA9(1), ITGAD(2), ITGAE(3), ITGAL(4), ITGAM(3), ITGAX(2), ITGB1(3), ITGB2(1), ITGB3(1), ITGB4(1), ITGB5(1), ITGB6(2), ITGB7(2), ITGB8(1), MAP2K3(3), MAP2K6(1), MAPK10(1), MAPK12(1), MAPK4(1), MYLK2(1), PAK1(1), PAK4(2), PAK6(4), PIK3R2(2), PTK2(1), RAC1(1), RAC3(1), RAPGEF1(2), RHO(1), ROCK1(4), ROCK2(3), SDCCAG8(1), SEPP1(1), SHC1(2), SHC3(1), SORBS1(1), SOS1(6), SRC(2), TLN1(4), TNS1(5), VAV2(4), VCL(2), ZYX(1) 83668064 128 109 128 45 9 22 19 60 18 0 0.782 1.000 1.000 504 HSA04070_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM Genes involved in phosphatidylinositol signaling system CALM1, CALM2, CALM3, CALML3, CALML6, CARKL, CDIPT, CDS1, CDS2, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, FN3K, IMPA1, IMPA2, INPP1, INPP4A, INPP4B, INPP5A, INPP5B, INPP5D, INPP5E, INPPL1, ITGB1BP3, ITPK1, ITPKA, ITPKB, ITPR1, ITPR2, ITPR3, OCRL, PI4KA, PI4KB, PIB5PA, PIK3C2A, PIK3C2B, PIK3C2G, PIK3C3, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PIP4K2A, PIP4K2B, PIP4K2C, PIP5K1A, PIP5K1B, PIP5K1C, PIP5K3, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCD3, PLCD4, PLCE1, PLCG1, PLCG2, PLCZ1, PRKCA, PRKCB1, PRKCG, PTEN, PTPMT1, SKIP, SYNJ1, SYNJ2 73 CALM2(1), CDS2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), FN3K(1), IMPA2(2), INPP4A(2), INPP4B(2), INPP5A(1), INPP5B(2), INPP5D(1), INPP5E(2), INPPL1(2), ITPKA(1), ITPKB(1), ITPR1(2), ITPR2(8), ITPR3(3), OCRL(1), PI4KA(8), PI4KB(1), PIK3C2B(3), PIK3C2G(2), PIK3C3(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PIP4K2A(1), PIP5K1A(2), PIP5K1C(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCD4(3), PLCE1(3), PLCG2(1), PRKCG(1), PTEN(20), PTPMT1(1), SYNJ1(4), SYNJ2(5) 77975305 130 108 124 35 9 23 11 51 35 1 0.313 1.000 1.000 505 STRIATED_MUSCLE_CONTRACTION ACTA1, ACTA2, ACTC, ACTN2, ACTN3, ACTN4, C9orf97, DES, DES, FAM48A, DMD, MYBPC1, MYBPC2, MYBPC3, MYH3, MYH6, MYH6, MYH7, MYH8, MYL1, MYL2, MYL3, MYL4, MYL9, MYOM1, NEB, TCAP, TMOD1, TNNC2, TNNI1, TNNI2, TNNI3, TNNT1, TNNT2, TNNT3, TPM1, TPM2, TPM3, TPM4, TPM4, TTN, VIM 37 ACTN2(3), ACTN3(1), ACTN4(1), DMD(5), FAM48A(1), MYBPC1(1), MYBPC2(3), MYBPC3(1), MYH3(5), MYH6(3), MYH7(2), MYH8(1), MYL1(1), MYL2(1), MYL9(1), MYOM1(3), NEB(11), TMOD1(2), TNNI1(1), TNNT1(2), TNNT3(1), TPM2(1), TTN(75) 87431342 126 107 126 35 12 22 10 57 23 2 0.427 1.000 1.000 506 PURINE_METABOLISM 1_Sep, ADA, ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADK, ADSL, ADSS, AK1, AK2, AK5, ALLC, AMPD1, AMPD2, AMPD3, APRT, ATIC, ATP1B1, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, CANT1, DCK, DGUOK, ECGF1, ENPP1, ENPP3, ENTPD1, ENTPD2, FHIT, GART, GDA, GMPS, GUCY1A2, GUCY1A3, GUCY1B2, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, GUK1, HPRT1, IMPDH1, IMPDH2, ITPA, NME1, NME2, NP, NPR1, NPR2, NT5C, NT5E, NT5M, NUDT2, PAICS, PAPSS1, PAPSS2, PDE1A, PDE4A, PDE4B, PDE4C, PDE4D, PDE5A, PDE6B, PDE6C, PDE6G, PDE7B, PDE8A, PDE9A, PFAS, PKLR, PKM2, POLA, POLB, POLD1, POLD2, POLE, POLG, POLL, POLQ, POLR1B, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLRMT, POLS, PPAT, PRPS1, PRPS1L1, PRPS2, PRUNE, RRM1, RRM2, SAC 110 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADSL(1), AK2(1), AK5(1), ALLC(2), AMPD1(1), AMPD2(1), AMPD3(2), ATIC(1), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), CANT1(1), ENPP3(1), ENTPD2(1), GDA(1), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HPRT1(1), IMPDH1(1), IMPDH2(1), NPR1(3), NPR2(2), NT5M(2), PAPSS1(3), PAPSS2(2), PDE1A(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE5A(1), PDE6B(2), PDE6C(2), PDE8A(2), PFAS(1), PKM2(1), POLB(1), POLD1(3), POLE(4), POLG(2), POLL(2), POLQ(5), POLR1B(2), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLRMT(1), PRPS1(1), PRPS1L1(1), PRPS2(2), PRUNE(2), RRM1(2), RRM2(1) 79097280 121 105 121 24 13 14 12 57 25 0 0.0778 1.000 1.000 507 GPCRDB_CLASS_A_RHODOPSIN_LIKE ADORA1, ADORA2A, ADORA2B, ADORA3, ADRA1A, ADRA1B, ADRA1D, ADRA2A, ADRA2C, ADRB1, ADRB2, ADRB3, AGTR1, AGTR2, AGTRL1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCBP2, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CCR9, CCRL1, CCRL2, CHML, CHRM1, CHRM2, CHRM3, CHRM4, CHRM5, CMKLR1, CMKOR1, CNR1, CNR2, CX3CR1, CXCR3, CXCR4, DRD1, DRD2, DRD3, DRD4, DRD5, EDNRA, EDNRB, ELA3A, F2R, F2RL1, F2RL2, F2RL3, FPR1, FPRL1, FPRL2, FSHR, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GPR10, GPR147, GPR17, GPR173, GPR174, GPR23, GPR24, GPR27, GPR3, GPR30, GPR35, GPR37, GPR37L1, GPR4, GPR44, GPR50, GPR6, GPR63, GPR74, GPR77, GPR83, GPR85, GPR87, GPR92, GRPR, HCRTR1, HCRTR2, HRH1, HRH2, HRH3, HTR1A, HTR1B, HTR1D, HTR1E, HTR1F, HTR2A, HTR2B, HTR2C, HTR4, HTR5A, HTR6, HTR7, HTR7, LOC93164, IL8RA, IL8RB, LHCGR, LTB4R, MAS1, MC1R, MC3R, MC4R, MC5R, MLNR, MTNR1A, MTNR1B, NMBR, NMUR1, NMUR2, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPN1SW, OPN3, OPRD1, OPRK1, OPRL1, OPRM1, OR10A5, OR11A1, OR12D3, OR1C1, OR1F1, OR1Q1, OR2H1, OR5V1, OR5V1, OR12D3, OR7A5, OR7C1, OR8B8, OXTR, P2RY1, P2RY10, P2RY11, P2RY12, P2RY13, P2RY14, P2RY2, P2RY5, P2RY6, PPYR1, PTAFR, PTGDR, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, Rgr, RGR, RHO, RRH, SSTR1, SSTR2, SSTR3, SSTR4, SUCNR1, TBXA2R, TRHR 161 ADORA2A(1), ADORA2B(1), ADRA1A(1), ADRB2(2), AGTR1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCBP2(1), CCKAR(2), CCKBR(2), CCR6(1), CCR9(1), CHML(1), CHRM2(2), CHRM3(2), CHRM5(2), CMKLR1(1), CNR1(1), CNR2(1), CXCR4(1), DRD1(1), DRD2(1), DRD3(2), DRD5(1), EDNRB(1), F2RL1(1), F2RL2(1), FPR1(1), GALR1(1), GALT(2), GPR17(1), GPR173(2), GPR174(2), GPR35(1), GPR37(1), GPR37L1(1), GPR4(1), GPR50(1), GPR63(1), GPR77(1), GPR83(1), GPR85(2), HCRTR2(1), HRH2(1), HTR1A(2), HTR1E(3), HTR1F(1), HTR2A(1), HTR2C(1), HTR4(1), HTR6(1), HTR7(1), MAS1(1), MC3R(2), MC4R(1), MC5R(1), MTNR1B(1), NMBR(1), NMUR2(4), NPY1R(1), NTSR1(1), OPN1SW(1), OPRD1(2), OPRM1(2), OR12D3(1), OR1C1(1), OR1F1(1), OR5V1(2), OR7A5(1), OR7C1(1), OR8B8(2), P2RY10(1), P2RY11(1), P2RY12(1), P2RY13(1), P2RY14(1), P2RY2(1), PTAFR(1), PTGDR(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), RHO(1), SSTR1(2), SSTR3(1), SSTR4(1), TBXA2R(1), TRHR(2) 71443225 119 104 119 36 22 13 15 54 15 0 0.318 1.000 1.000 508 HSA04660_T_CELL_RECEPTOR_SIGNALING_PATHWAY Genes involved in T cell receptor signaling pathway AKT1, AKT2, AKT3, BCL10, CARD11, CBL, CBLB, CBLC, CD247, CD28, CD3D, CD3E, CD3G, CD4, CD40LG, CD8A, CD8B, CDC42, CDK4, CHP, CHUK, CSF2, CTLA4, FOS, FYN, GRAP2, GRB2, HRAS, ICOS, IFNG, IKBKB, IKBKG, IL10, IL2, IL4, IL5, ITK, JUN, KRAS, LAT, LCK, LCP2, MALT1, MAP3K14, MAP3K8, NCK1, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NRAS, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PDCD1, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCQ, PTPN6, PTPRC, RASGRP1, RHOA, SOS1, SOS2, TEC, TNF, VAV1, VAV2, VAV3, ZAP70 92 AKT1(2), AKT2(3), AKT3(2), BCL10(1), CARD11(4), CBL(1), CBLB(2), CBLC(1), CD28(1), CD3E(2), CD3G(1), CD4(2), CDC42(1), CDK4(1), CHUK(1), FYN(1), GRAP2(1), GRB2(1), HRAS(1), IL4(1), ITK(1), JUN(2), KRAS(1), LCP2(1), MALT1(2), MAP3K14(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), NFKBIB(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PDK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCQ(3), PTPN6(3), PTPRC(6), SOS1(6), SOS2(1), TEC(5), VAV1(2), VAV2(4) 61999380 120 101 115 27 4 24 15 64 13 0 0.160 1.000 1.000 509 G_PROTEIN_SIGNALING ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, AKAP1, AKAP10, AKAP11, AKAP12, AKAP2, PALM2_AKAP2, AKAP3, AKAP4, AKAP5, AKAP6, AKAP7, AKAP8, AKAP9, ARHGEF1, CALM1, CALM2, CALM3, CHMP1B, GNA11, GNA12, GNA13, GNA14, GNA15, GNAI2, GNAI3, GNAL, GNAO1, GNAQ, GNAZ, GNB1, GNB2, GNB3, GNB5, GNG10, GNG10, LOC552891, GNG12, GNG13, GNG3, GNG4, GNG5, GNG7, GNGT1, GNGT2, HRAS, IL18BP, ITPR1, KCNJ3, KRAS, MGC11266, NRAS, PALM2, PALM2_AKAP2, PALM2_AKAP2, PDE1A, PDE1B, PDE1C, PDE4A, PDE4B, PDE4C, PDE4D, PDE7A, PDE7B, PDE8A, PDE8B, PLCB3, PPP3CA, PPP3CC, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCQ, PRKCZ, PRKD1, PRKD3, RHOA, RRAS, SARA1, SLC9A1, USP5 92 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), AKAP1(2), AKAP11(1), AKAP12(3), AKAP3(1), AKAP4(2), AKAP6(4), AKAP7(1), AKAP9(11), ARHGEF1(1), CALM2(1), CHMP1B(2), GNA13(4), GNA15(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAZ(1), GNB1(2), GNB5(1), GNG12(1), GNG3(1), HRAS(1), IL18BP(1), ITPR1(2), KCNJ3(3), KRAS(1), PDE1A(1), PDE1B(2), PDE1C(1), PDE4A(2), PDE4B(2), PDE4C(6), PDE4D(1), PDE8A(2), PDE8B(1), PLCB3(1), PPP3CA(1), PPP3CC(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKD3(2), SLC9A1(2), USP5(1) 72519872 123 100 123 30 12 17 5 65 24 0 0.283 1.000 1.000 510 HSA04650_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY Genes involved in natural killer cell mediated cytotoxicity ARAF, BID, BRAF, CASP3, CD244, CD247, CD48, CHP, CSF2, FAS, FASLG, FCER1G, FCGR3A, FCGR3B, FYN, GRB2, GZMB, HCST, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HRAS, ICAM1, ICAM2, IFNA1, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA2, IFNA21, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNAR1, IFNAR2, IFNB1, IFNG, IFNGR1, IFNGR2, ITGAL, ITGB2, KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DS1, KIR2DS2, KIR3DL1, KIR3DL2, KLRC1, KLRC2, KLRC3, KLRD1, KLRK1, KRAS, LAT, LCK, LCP2, LOC652578, MAP2K1, MAP2K2, MAPK1, MAPK3, MICA, MICB, NCR1, NCR2, NCR3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NRAS, PAK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRF1, PRKCA, PRKCB1, PRKCG, PTK2B, PTPN11, PTPN6, RAC1, RAC2, RAC3, RAF1, SH2D1A, SH2D1B, SH3BP2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SYK, TNF, TNFRSF10A, TNFRSF10B, TNFRSF10C, TNFRSF10D, TNFSF10, TYROBP, ULBP1, ULBP2, ULBP3, VAV1, VAV2, VAV3, ZAP70 126 BID(1), BRAF(1), FAS(1), FASLG(1), FCGR3B(1), FYN(1), GRB2(1), HLA-C(2), HLA-E(2), HRAS(1), IFNA1(2), IFNA14(1), IFNA16(1), IFNA21(1), IFNA5(1), IFNA8(2), IFNAR1(1), IFNB1(2), IFNGR1(2), IFNGR2(1), ITGAL(4), ITGB2(1), KIR3DL1(1), KLRC1(2), KLRC2(4), KRAS(1), LCP2(1), MAPK3(1), MICA(1), MICB(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PAK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRF1(1), PRKCG(1), PTK2B(2), PTPN11(1), PTPN6(3), RAC1(1), RAC3(1), SH3BP2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SYK(1), TNFSF10(1), ULBP2(1), ULBP3(1), VAV1(2), VAV2(4) 68850097 118 100 112 43 5 25 18 57 13 0 0.840 1.000 1.000 511 HSA04730_LONG_TERM_DEPRESSION Genes involved in long-term depression ARAF, BRAF, C7orf16, CACNA1A, CRH, CRHR1, GNA11, GNA12, GNA13, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GNAZ, GRIA1, GRIA2, GRIA3, GRID2, GRM1, GRM5, GUCY1A2, GUCY1A3, GUCY1B3, GUCY2C, GUCY2D, GUCY2F, HRAS, IGF1, IGF1R, ITPR1, ITPR2, ITPR3, KRAS, LYN, MAP2K1, MAP2K2, MAPK1, MAPK3, NOS1, NOS2A, NOS3, NPR1, NPR2, NRAS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB1, PLCB2, PLCB3, PLCB4, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, PRKCA, PRKCB1, PRKCG, PRKG1, PRKG2, RAF1, RYR1 74 BRAF(1), CACNA1A(5), GNA13(4), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), GNAZ(1), GRIA1(4), GRIA2(3), GRID2(4), GRM1(4), GRM5(4), GUCY1A2(1), GUCY1A3(2), GUCY1B3(1), GUCY2C(1), GUCY2F(2), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), NOS1(8), NOS3(2), NPR1(3), NPR2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), PRKCG(1), PRKG1(2), PRKG2(2), RYR1(11) 68427272 115 100 115 43 17 13 11 55 19 0 0.883 1.000 1.000 512 HSA04012_ERBB_SIGNALING_PATHWAY Genes involved in ErbB signaling pathway ABL1, ABL2, AKT1, AKT2, AKT3, ARAF, AREG, BAD, BRAF, BTC, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CBL, CBLB, CBLC, CDKN1A, CDKN1B, CRK, CRKL, EGF, EGFR, EIF4EBP1, ELK1, ERBB2, ERBB3, ERBB4, EREG, FRAP1, GAB1, GRB2, GSK3B, HBEGF, HRAS, JUN, KRAS, MAP2K1, MAP2K2, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK3, MAPK8, MAPK9, MYC, NCK1, NCK2, NRAS, NRG1, NRG2, NRG3, NRG4, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCG, PTK2, RAF1, RPS6KB1, RPS6KB2, SHC1, SHC2, SHC3, SHC4, SOS1, SOS2, SRC, STAT5A, STAT5B, TGFA 85 ABL1(4), ABL2(2), AKT1(2), AKT2(3), AKT3(2), BRAF(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CBL(1), CBLB(2), CBLC(1), CDKN1A(1), EGF(4), EGFR(7), ELK1(1), ERBB2(4), ERBB3(3), ERBB4(6), GAB1(1), GRB2(1), HRAS(1), JUN(2), KRAS(1), MAP2K7(1), MAPK10(1), MAPK3(1), MAPK9(2), MYC(1), NRG1(4), NRG2(2), NRG3(2), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLCG2(1), PRKCG(1), PTK2(1), RPS6KB1(1), RPS6KB2(1), SHC1(2), SHC2(1), SHC3(1), SOS1(6), SOS2(1), SRC(2), STAT5B(1) 63099338 119 99 114 29 9 28 14 57 11 0 0.116 1.000 1.000 513 PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM ACVR1, ACVR1B, ACVRL1, AKT1, AURKB, BMPR1A, BMPR2, BUB1, CDC2L5, CDIPT, CDKL1, CDKL2, CDS1, CDS2, CLK1, CLK2, CLK4, COL4A3BP, CSNK2A1, CSNK2A1, CSNK2A1P, CSNK2A2, CSNK2B, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MAP3K10, MOS, NEK1, NEK3, OCRL, PAK4, PCTK1, PCTK2, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIM2, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2, PLK3, PRKACA, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, PRKCZ, PRKD1, PRKG1, RAF1, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA4, RPS6KB1, STK11, TGFBR1, VRK1 82 ACVR1B(4), AKT1(2), AURKB(1), BMPR2(4), CDS2(1), CLK1(4), CLK2(2), CLK4(2), COL4A3BP(1), CSNK2A2(1), CSNK2B(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MAP3K10(3), NEK1(2), NEK3(2), OCRL(1), PAK4(2), PIK3C2B(3), PIK3C2G(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1), PLK3(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCQ(3), PRKCZ(2), PRKD1(3), PRKG1(2), RPS6KA1(2), RPS6KB1(1), STK11(1) 70509482 112 96 108 30 8 24 7 51 22 0 0.313 1.000 1.000 514 HSA00500_STARCH_AND_SUCROSE_METABOLISM Genes involved in starch and sucrose metabolism AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHX58, ENPP1, ENPP3, ENTPD7, EP400, ERCC2, ERCC3, G6PC, G6PC2, GAA, GANC, GBA, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, IFIH1, LYZL1, MGAM, MOV10L1, NUDT5, NUDT8, PGM1, PGM3, PYGB, PYGL, PYGM, RAD54B, RAD54L, RUVBL2, SETX, SI, SKIV2L2, SMARCA2, SMARCA5, TREH, UGDH, UGP2, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7, UXS1 80 AGL(4), AMY2A(1), AMY2B(1), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), ENPP3(1), EP400(5), ERCC2(1), ERCC3(1), G6PC(2), GAA(1), GANC(1), GBA(2), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), IFIH1(2), MGAM(2), MOV10L1(3), PYGB(2), PYGL(1), PYGM(2), RAD54L(2), RUVBL2(2), SETX(5), SI(6), SMARCA2(4), SMARCA5(1), UGP2(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2), UXS1(1) 77200858 117 95 115 37 5 20 21 43 28 0 0.607 1.000 1.000 515 HSA02010_ABC_TRANSPORTERS_GENERAL Genes involved in ABC transporters - general ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD1, ABCD2, ABCD3, ABCD4, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2 44 ABCA1(7), ABCA10(4), ABCA12(7), ABCA13(12), ABCA2(3), ABCA3(3), ABCA4(5), ABCA5(6), ABCA6(1), ABCA7(6), ABCA8(3), ABCA9(2), ABCB1(4), ABCB11(1), ABCB4(1), ABCB5(3), ABCB6(1), ABCC1(2), ABCC10(3), ABCC11(1), ABCC12(3), ABCC2(1), ABCC3(7), ABCC4(3), ABCC5(4), ABCC6(4), ABCC8(1), ABCC9(4), ABCD2(1), ABCD3(2), ABCD4(3), ABCG1(1), ABCG4(3), ABCG5(1), ABCG8(2), CFTR(4) 72984357 119 94 118 36 6 20 17 60 15 1 0.468 1.000 1.000 516 HSA01030_GLYCAN_STRUCTURES_BIOSYNTHESIS_1 Genes involved in glycan structures - biosynthesis 1 A4GNT, ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG6, ALG8, ALG9, B3GALT6, B3GNT1, B3GNT2, B3GNT6, B3GNT7, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT5, B4GALT7, C1GALT1, C1GALT1C1, ChGn, CHPF, CHST1, CHST11, CHST12, CHST13, CHST14, CHST2, CHST3, CHST4, CHST6, CHST7, CHSY-2, CHSY1, CSGlcA-T, DAD1, DDOST, DPAGT1, EXT1, EXT2, EXTL1, EXTL2, EXTL3, FUT11, FUT8, GALNAC4S-6ST, GALNACT-2, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GANAB, GCNT1, GCNT3, GCNT4, GCS1, HS2ST1, HS3ST1, HS3ST2, HS3ST3A1, HS3ST3B1, HS3ST5, HS6ST1, HS6ST2, HS6ST3, LOC728969, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, NDST1, NDST2, NDST3, NDST4, OGT, RPN1, RPN2, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST6GAL1, ST6GALNAC1, STT3B, UST, WBSCR17, XYLT1, XYLT2 107 A4GNT(1), ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG6(1), ALG8(2), B3GNT2(2), B3GNT6(1), B3GNT7(1), B4GALT3(1), B4GALT4(2), B4GALT5(1), CHST1(1), CHST11(1), CHST12(1), CHST4(1), CHST7(1), CHSY1(2), DPAGT1(2), EXT1(1), EXT2(1), EXTL1(1), EXTL3(2), FUT11(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), HS2ST1(1), HS3ST5(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), NDST1(2), NDST2(2), NDST4(3), OGT(4), RPN1(2), RPN2(1), ST3GAL1(1), ST3GAL3(1), ST6GALNAC1(1), STT3B(2), WBSCR17(4), XYLT1(1), XYLT2(2) 66116349 105 91 105 34 4 20 14 46 21 0 0.718 1.000 1.000 517 HSA04350_TGF_BETA_SIGNALING_PATHWAY Genes involved in TGF-beta signaling pathway ACVR1, ACVR1B, ACVR1C, ACVR2A, ACVR2B, ACVRL1, AMH, AMHR2, BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BMPR1A, BMPR1B, BMPR2, CDKN2B, CHRD, COMP, CREBBP, CUL1, DCN, E2F4, E2F5, EP300, FST, GDF5, GDF6, GDF7, hCG_1982709, ID1, ID2, ID3, ID4, IFNG, INHBA, INHBB, INHBC, INHBE, LEFTY1, LEFTY2, LTBP1, MAPK1, MAPK3, MYC, NODAL, NOG, PITX2, PPP2CA, PPP2CB, PPP2R1A, PPP2R1B, PPP2R2A, PPP2R2B, PPP2R2C, RBL1, RBL2, RBX1, RHOA, ROCK1, ROCK2, RPS6KB1, RPS6KB2, SKP1, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, SMAD6, SMAD7, SMAD9, SMURF1, SMURF2, SP1, TFDP1, TGFB1, TGFB2, TGFB3, TGFBR1, TGFBR2, THBS1, THBS2, THBS3, THBS4, TNF, ZFYVE16, ZFYVE9 88 ACVR1B(4), ACVR1C(1), ACVR2A(1), ACVR2B(1), AMHR2(2), BMP2(1), BMP5(1), BMP6(1), BMP7(2), BMPR1B(1), BMPR2(4), CHRD(2), CREBBP(4), CUL1(3), DCN(3), E2F5(1), EP300(6), GDF5(1), GDF6(1), INHBA(2), INHBB(1), INHBC(1), INHBE(1), LTBP1(2), MAPK3(1), MYC(1), PITX2(1), PPP2CA(1), PPP2CB(1), PPP2R1A(2), PPP2R1B(1), PPP2R2A(1), PPP2R2B(4), PPP2R2C(1), RBL2(2), ROCK1(4), ROCK2(3), RPS6KB1(1), RPS6KB2(1), SMAD2(2), SMAD3(1), SMAD4(1), SMAD9(1), SMURF2(3), TGFB2(2), TGFB3(1), TGFBR2(1), THBS1(6), THBS2(1), THBS3(6), THBS4(3), ZFYVE16(1), ZFYVE9(4) 60246080 105 91 104 28 5 10 14 54 22 0 0.532 1.000 1.000 518 CELL_CYCLE_KEGG ABL1, ASK, ATM, BUB1, BUB1B, BUB3, CCNA1, CCNA2, CCNB1, CCNB2, CCNB3, CCND2, CCND3, CCNE1, CCNE2, CCNH, CDAN1, CDC14A, CDC14B, CDC14B, CDC14C, CDC2, CDC20, CDC25A, CDC25B, CDC25C, CDC45L, CDC6, CDC7, CDH1, CDK2, CDK4, CDKN1A, CDKN2A, CHEK1, CHEK2, DTX4, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, EP300, ESPL1, FLJ14001, GADD45A, GSK3B, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HDAC7A, HDAC8, MAD1L1, MAD2L1, MAD2L2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MPEG1, MPL, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, PLK1, PRKDC, PTPRA, PTTG1, PTTG2, PTTG3, RB1, RBL1, SKP2, SMAD4, SMC1L1, TBC1D8, TFDP1, TGFB1, TP53, WEE1 82 ABL1(4), ATM(15), BUB3(1), CCNA1(3), CCNB2(5), CCNB3(6), CCND2(1), CCNE1(2), CCNH(1), CDAN1(3), CDC14A(3), CDC20(1), CDC25A(1), CDC25C(2), CDC7(1), CDH1(2), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CHEK2(1), E2F1(1), E2F5(1), EP300(6), ESPL1(7), HDAC1(2), HDAC4(1), HDAC6(2), MAD2L1(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), ORC1L(1), ORC2L(1), PCNA(3), PRKDC(5), PTPRA(1), RB1(1), SKP2(1), SMAD4(1), TBC1D8(1), TP53(10), WEE1(1) 68936071 116 90 116 35 8 19 22 48 19 0 0.382 1.000 1.000 519 HSA04916_MELANOGENESIS Genes involved in melanogenesis ADCY1, ADCY2, ADCY3, ADCY4, ADCY5, ADCY6, ADCY7, ADCY8, ADCY9, ASIP, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CREB1, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREBBP, CTNNB1, DCT, DVL1, DVL2, DVL3, EDN1, EDNRB, EP300, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9, GNAI1, GNAI2, GNAI3, GNAO1, GNAQ, GNAS, GSK3B, HRAS, KIT, KITLG, KRAS, LEF1, LOC652788, MAP2K1, MAP2K2, MAPK1, MAPK3, MC1R, MITF, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, POMC, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, TCF7, TCF7L1, TCF7L2, TYR, TYRP1, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B 99 ADCY1(1), ADCY2(3), ADCY3(3), ADCY5(3), ADCY6(1), ADCY8(6), ADCY9(3), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CREB3L1(1), CREB3L2(1), CREB3L4(1), CREBBP(4), CTNNB1(1), DCT(4), DVL1(1), EDNRB(1), EP300(6), FZD1(2), FZD10(2), FZD3(1), FZD4(3), FZD5(1), GNAI1(1), GNAI2(1), GNAI3(1), GNAO1(1), GNAS(4), HRAS(1), KIT(3), KITLG(2), KRAS(1), LEF1(1), MAPK3(1), MITF(2), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), TCF7L2(1), TYR(3), TYRP1(1), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1) 65676689 104 90 104 28 9 10 13 56 16 0 0.421 1.000 1.000 520 HSA04720_LONG_TERM_POTENTIATION Genes involved in long-term potentiation ADCY1, ADCY8, ARAF, ATF4, BRAF, CACNA1C, CALM1, CALM2, CALM3, CALML3, CALML6, CAMK2A, CAMK2B, CAMK2D, CAMK2G, CAMK4, CHP, CREBBP, EP300, GNAQ, GRIA1, GRIA2, GRIN1, GRIN2A, GRIN2B, GRIN2C, GRIN2D, GRM1, GRM5, HRAS, ITPR1, ITPR2, ITPR3, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK3, NRAS, PLCB1, PLCB2, PLCB3, PLCB4, PPP1CA, PPP1CB, PPP1CC, PPP1R12A, PPP1R1A, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKACA, PRKACB, PRKACG, PRKCA, PRKCB1, PRKCG, PRKX, PRKY, RAF1, RAP1A, RAP1B, RAPGEF3, RPS6KA1, RPS6KA2, RPS6KA3, RPS6KA6 67 ADCY1(1), ADCY8(6), ATF4(1), BRAF(1), CACNA1C(8), CALM2(1), CAMK2A(1), CAMK2B(1), CAMK2D(1), CAMK2G(2), CAMK4(1), CREBBP(4), EP300(6), GRIA1(4), GRIA2(3), GRIN1(2), GRIN2A(4), GRIN2B(5), GRM1(4), GRM5(4), HRAS(1), ITPR1(2), ITPR2(8), ITPR3(3), KRAS(1), MAPK3(1), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PPP1R12A(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKACA(1), PRKACB(4), PRKACG(2), PRKCG(1), RAP1A(1), RAPGEF3(2), RPS6KA1(2), RPS6KA6(1) 62722718 102 89 102 23 13 14 10 53 12 0 0.105 1.000 1.000 521 CALCINEURIN_NF_AT_SIGNALING Mouse genes associated with signal transduction through calcium, calcineurin, and NF-AT. ACTB, BAD, BCL2, CABIN1, CALM1, CALM2, CALM3, CAMK2B, CAMK4, CD3E, CD3G, CD3Z, CD69, CDKN1A, CEBPB, CNR1, CREBBP, CSF2, CSNK2A1, CSNK2B, CTLA4, EGR2, EGR3, EP300, FCER1A, FCGR3A, FKBP1B, FLJ14639, FOS, FOSL1, GAPD, GATA3, GATA4, GRLF1, GSK3A, GSK3B, HRAS, ICOS, IFNA1, IFNB1, IFNG, IL10, IL13, IL1B, IL2, IL2RA, IL3, IL4, IL6, IL8, IL8RA, ITK, JUNB, KPNA5, KPNB3, MAP2K7, MAPK14, MAPK8, MAPK9, MEF2A, MEF2B, MEF2D, MYF5, NCK2, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NFKB2, NFKBIB, NFKBIE, NPPB, NUP214, OPRD1, P2RX7, PAK1, PIN1, PPIA, PPP3CB, PPP3CC, PPP3R1, PTPRC, RELA, RPL13A, SFN, SLA, SP1, SP3, TGFB1, TNF, TNFSF5, TNFSF6, TRAF2, TRPV6, VAV1, VAV2, VAV3, VEGF, XPO5 91 CABIN1(5), CALM2(1), CAMK2B(1), CAMK4(1), CD3E(2), CD3G(1), CDKN1A(1), CNR1(1), CREBBP(4), CSNK2B(1), EGR2(1), EGR3(1), EP300(6), GATA4(1), GRLF1(6), GSK3A(2), HRAS(1), IFNA1(2), IFNB1(2), IL2RA(2), IL3(1), IL4(1), ITK(1), JUNB(2), MAP2K7(1), MAPK14(1), MAPK9(2), MEF2A(1), MEF2D(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKBIB(1), NPPB(1), NUP214(2), OPRD1(2), PAK1(1), PPP3CC(1), PTPRC(6), RELA(1), SP3(1), TRPV6(4), VAV1(2), VAV2(4), XPO5(2) 55354822 96 84 95 26 8 15 13 47 13 0 0.348 1.000 1.000 522 MRNA_PROCESSING_REACTOME BRUNOL4, C10orf9, C20orf14, CD2BP2, CDC40, CLK2, CLK3, CLK4, COL2A1, CPSF1, CPSF2, CPSF3, CPSF4, CSTF1, CSTF2, CSTF2T, CSTF3, CUGBP1, CUGBP2, DDIT3, DDX1, DDX20, DHX15, DHX16, DHX38, DHX8, DHX9, DICER1, DNAJC8, FLJ10748, FNBP3, FUS, FUSIP1, GIPC1, HEAB, HNRPA2B1, HNRPA3, HNRPA3P1, HNRPA3, LOC387933, HNRPA3P1, HNRPA3, LOC389395, HNRPAB, HNRPC, HNRPC, HNRPCL1, LOC390615, LOC440563, HNRPD, HNRPH1, HNRPH2, HNRPL, HNRPR, HNRPU, HRMT1L2, LSM2, LSM7, METTL3, NCBP1, NCBP2, NONO, NUDT21, NXF1, PABPN1, PAPOLA, PHF5A, POLR2A, PPM1G, PRPF18, PRPF3, PRPF4, PRPF4B, PRPF8, PSKH1, PTBP1, PTBP2, RBM17, RBM5, RNGTT, RNMT, RNPC2, RNPS1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B4, SF3B5, SF4, SFRS10, SFRS12, SFRS14, SFRS16, SFRS2, SFRS4, SFRS5, SFRS6, SFRS7, SFRS8, SFRS9, SMC1L1, SNRP70, SNRPA, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNRPN, SNRPN, PAR1, SNRPN, SNURF, SPOP, SRPK1, SRPK2, SRRM1, SUPT5H, TMP21, TXNL4A, U2AF1, U2AF2, WDR57, XRN2 92 CDC40(1), CLK2(2), CLK4(2), COL2A1(5), CPSF1(3), CPSF2(2), CPSF3(2), CPSF4(2), CSTF2T(1), CSTF3(3), DDX1(1), DDX20(4), DHX15(3), DHX8(1), DHX9(3), DICER1(2), FUS(4), LSM7(1), METTL3(4), NONO(2), NXF1(1), PAPOLA(3), POLR2A(6), PRPF3(1), PRPF4B(1), PRPF8(7), PSKH1(2), PTBP2(1), RBM17(1), RNMT(1), SF3A1(1), SF3A3(2), SF3B1(4), SF3B2(2), SF4(1), SFRS12(1), SFRS16(1), SFRS2(1), SNRPB(1), SNRPN(2), SRPK2(2), SRRM1(1), SUPT5H(5), TXNL4A(1), U2AF2(1), XRN2(3) 65315822 101 84 101 28 4 25 10 44 17 1 0.371 1.000 1.000 523 HSA04640_HEMATOPOIETIC_CELL_LINEAGE Genes involved in hematopoietic cell lineage ANPEP, CD14, CD19, CD1A, CD1B, CD1C, CD1D, CD1E, CD2, CD22, CD24, CD33, CD34, CD36, CD37, CD38, CD3D, CD3E, CD3G, CD4, CD44, CD5, CD55, CD59, CD7, CD8A, CD8B, CD9, CR1, CR2, CSF1, CSF1R, CSF2, CSF2RA, CSF3, CSF3R, DNTT, EPO, EPOR, FCER2, FCGR1A, FLT3, FLT3LG, GP1BA, GP1BB, GP5, GP9, GYPA, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, IL11, IL11RA, IL1A, IL1B, IL1R1, IL1R2, IL2RA, IL3, IL3RA, IL4, IL4R, IL5, IL5RA, IL6, IL6R, IL7, IL7R, IL9R, ITGA1, ITGA2, ITGA2B, ITGA3, ITGA4, ITGA5, ITGA6, ITGAM, ITGB3, KIT, KITLG, MME, MS4A1, TFRC, THPO, TNF, TPO 84 ANPEP(6), CD19(1), CD1D(3), CD1E(1), CD22(1), CD24(1), CD33(1), CD34(1), CD38(1), CD3E(2), CD3G(1), CD4(2), CD44(1), CD55(1), CR1(7), CR2(1), CSF1R(5), CSF2RA(3), CSF3R(2), DNTT(2), FLT3(2), GYPA(1), HLA-DRA(1), HLA-DRB5(2), IL1R1(1), IL2RA(2), IL3(1), IL4(1), IL4R(2), IL9R(2), ITGA1(3), ITGA2(1), ITGA3(2), ITGA4(1), ITGA5(1), ITGA6(4), ITGAM(3), ITGB3(1), KIT(3), KITLG(2), MME(3), TPO(3) 50449603 85 75 85 22 5 9 16 42 13 0 0.438 1.000 1.000 524 HSA04664_FC_EPSILON_RI_SIGNALING_PATHWAY Genes involved in Fc epsilon RI signaling pathway AKT1, AKT2, AKT3, BTK, CSF2, FCER1A, FCER1G, FYN, GAB2, GRB2, HRAS, IL13, IL3, IL4, IL5, INPP5D, KRAS, LAT, LCP2, LYN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAPK1, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPK8, MAPK9, MS4A2, NRAS, PDK1, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PRKCA, PRKCB1, PRKCD, PRKCE, RAC1, RAC2, RAC3, RAF1, SOS1, SOS2, SYK, TNF, VAV1, VAV2, VAV3 74 AKT1(2), AKT2(3), AKT3(2), BTK(1), FYN(1), GAB2(1), GRB2(1), HRAS(1), IL3(1), IL4(1), INPP5D(1), KRAS(1), LCP2(1), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), MAPK9(2), MS4A2(1), PDK1(1), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PRKCD(2), PRKCE(2), RAC1(1), RAC3(1), SOS1(6), SOS2(1), SYK(1), VAV1(2), VAV2(4) 44675958 79 72 75 26 7 18 11 37 6 0 0.521 1.000 1.000 525 HSA04920_ADIPOCYTOKINE_SIGNALING_PATHWAY Genes involved in adipocytokine signaling pathway ACACB, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ADIPOR1, ADIPOR2, AGRP, AKT1, AKT2, AKT3, CAMKK1, CAMKK2, CD36, CHUK, CPT1A, CPT1B, CPT1C, CPT2, FRAP1, G6PC, G6PC2, IKBKB, IKBKG, IRS1, IRS2, IRS4, JAK1, JAK2, JAK3, LEP, LEPR, MAPK10, MAPK8, MAPK9, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NPY, PCK1, PCK2, POMC, PPARA, PPARGC1A, PRKAA1, PRKAA2, PRKAB1, PRKAB2, PRKAG1, PRKAG2, PRKAG3, PRKCQ, PTPN11, RELA, RXRA, RXRB, RXRG, SLC2A1, SLC2A4, SOCS3, STAT3, STK11, TNF, TNFRSF1A, TNFRSF1B, TRADD, TRAF2, TYK2 69 ACACB(3), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), AKT1(2), AKT2(3), AKT3(2), CAMKK1(1), CAMKK2(2), CHUK(1), CPT1A(1), G6PC(2), IRS1(3), IRS4(1), JAK1(4), JAK2(5), JAK3(3), LEP(1), LEPR(1), MAPK10(1), MAPK9(2), NFKB1(1), NFKBIB(1), NPY(1), PCK1(4), PCK2(1), PPARGC1A(3), PRKAG1(1), PRKAG2(4), PRKCQ(3), PTPN11(1), RELA(1), RXRB(3), RXRG(2), SLC2A4(1), STAT3(1), STK11(1), TNFRSF1A(1), TRADD(1), TYK2(3) 49830098 79 72 79 22 3 15 12 34 15 0 0.443 1.000 1.000 526 HSA04370_VEGF_SIGNALING_PATHWAY Genes involved in VEGF signaling pathway AKT1, AKT2, AKT3, BAD, CASP9, CDC42, CHP, HRAS, KDR, KRAS, MAP2K1, MAP2K2, MAPK1, MAPK11, MAPK12, MAPK13, MAPK14, MAPK3, MAPKAPK2, MAPKAPK3, NFAT5, NFATC1, NFATC2, NFATC3, NFATC4, NOS3, NRAS, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PIK3R2, PIK3R3, PIK3R5, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCG1, PLCG2, PPP3CA, PPP3CB, PPP3CC, PPP3R1, PPP3R2, PRKCA, PRKCB1, PRKCG, PTGS2, PTK2, PXN, RAC1, RAC2, RAC3, RAF1, SH2D2A, SHC2, SPHK1, SPHK2, SRC, VEGFA 69 AKT1(2), AKT2(3), AKT3(2), CDC42(1), HRAS(1), KDR(5), KRAS(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK3(1), NFAT5(7), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NOS3(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PIK3R1(2), PIK3R2(2), PIK3R5(3), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLCG2(1), PPP3CA(1), PPP3CC(1), PPP3R2(1), PRKCG(1), PTGS2(4), PTK2(1), RAC1(1), RAC3(1), SHC2(1), SPHK2(1), SRC(2) 44021378 79 69 74 30 4 17 10 40 8 0 0.778 1.000 1.000 527 G1_TO_S_CELL_CYCLE_REACTOME ATM, CCNA1, CCNB1, CCND1, CCND2, CCND3, CCNE1, CCNE2, CCNG2, CCNH, CDC25A, CDC45L, CDK2, CDK4, CDK7, CDKN1A, CDKN1B, CDKN1C, CDKN2A, CDKN2B, CDKN2C, CDKN2D, CREB3, CREB3L1, CREB3L3, CREB3L4, CREBL1, CREBL1, TNXB, E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, FLJ14001, GADD45A, GBA2, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, MDM2, MNAT1, MYC, MYT1, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA2, POLE, POLE2, PRIM1, PRIM2A, RB1, RBL1, RPA1, RPA2, RPA3, TFDP1, TFDP2, TP53, WEE1 64 ATM(15), CCNA1(3), CCND2(1), CCNE1(2), CCNG2(1), CCNH(1), CDC25A(1), CDK2(2), CDK4(1), CDKN1A(1), CDKN2A(3), CDKN2C(1), CREB3L1(1), CREB3L4(1), E2F1(1), E2F5(1), GBA2(4), MCM2(3), MCM5(1), MCM6(2), MCM7(4), MYC(1), MYT1(2), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLE(4), POLE2(1), PRIM1(2), RB1(1), RPA2(1), RPA3(1), TFDP2(5), TNXB(1), TP53(10), WEE1(1) 46187944 86 68 86 24 5 11 12 39 19 0 0.486 1.000 1.000 528 HSA00240_PYRIMIDINE_METABOLISM Genes involved in pyrimidine metabolism AICDA, AK3, CAD, CANT1, CDA, CMPK, CTPS, CTPS2, DCK, DCTD, DHODH, DPYD, DPYS, DTYMK, DUT, ECGF1, ENTPD1, ENTPD3, ENTPD4, ENTPD5, ENTPD6, ENTPD8, ITPA, NME1, NME2, NME4, NME6, NME7, NP, NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3, NT5E, NT5M, NUDT2, PNPT1, POLA1, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, POLE3, POLE4, POLR1A, POLR1B, POLR1C, POLR1D, POLR2A, POLR2B, POLR2C, POLR2D, POLR2E, POLR2F, POLR2G, POLR2H, POLR2I, POLR2J, POLR2K, POLR2L, POLR3A, POLR3B, POLR3G, POLR3GL, POLR3H, POLR3K, PRIM1, PRIM2, RFC5, RRM1, RRM2, RRM2B, TK1, TK2, TXNRD1, TXNRD2, TYMS, UCK1, UCK2, UMPS, UPB1, UPP1, UPP2, UPRT, ZNRD1 86 AICDA(1), CAD(4), CANT1(1), CTPS(1), DCTD(1), DPYD(1), DPYS(2), NT5C1B(1), NT5C2(1), NT5C3(1), NT5M(2), POLA1(1), POLD1(3), POLD3(1), POLE(4), POLE2(1), POLR1A(2), POLR1B(2), POLR1C(3), POLR2A(6), POLR2B(4), POLR2F(1), POLR2I(1), POLR3A(4), POLR3B(2), POLR3G(1), POLR3H(1), POLR3K(1), PRIM1(2), PRIM2(3), RFC5(1), RRM1(2), RRM2(1), TK1(1), TK2(1), TXNRD2(1), UCK1(1), UCK2(1), UMPS(1), UPB1(2), UPP2(2), UPRT(1) 50635943 74 67 73 18 2 14 13 28 17 0 0.150 1.000 1.000 529 HSA03320_PPAR_SIGNALING_PATHWAY Genes involved in PPAR signaling pathway ACAA1, ACADL, ACADM, ACOX1, ACOX2, ACOX3, ACSL1, ACSL3, ACSL4, ACSL5, ACSL6, ADIPOQ, ANGPTL4, APOA1, APOA2, APOA5, APOC3, AQP7, CD36, CPT1A, CPT1B, CPT1C, CPT2, CYP27A1, CYP4A11, CYP4A22, CYP7A1, CYP8B1, DBI, EHHADH, FABP1, FABP2, FABP3, FABP4, FABP5, FABP5L1, FABP6, FABP7, FADS2, GK, GK2, HMGCS2, ILK, LOC642956, LPL, ME1, MMP1, NR1H3, OLR1, PCK1, PCK2, PDPK1, PLIN, PLTP, PPARA, PPARD, PPARG, RXRA, RXRB, RXRG, SCD, SCP2, SLC27A1, SLC27A2, SLC27A4, SLC27A5, SLC27A6, SORBS1, UBC, UCP1 67 ACADM(1), ACOX1(1), ACOX2(1), ACOX3(2), ACSL3(1), ACSL4(1), ACSL5(1), ACSL6(4), ANGPTL4(2), APOA5(2), AQP7(1), CPT1A(1), CYP4A11(4), CYP4A22(1), CYP8B1(3), DBI(1), EHHADH(2), FABP1(1), FADS2(2), GK2(1), HMGCS2(1), ILK(1), LPL(1), ME1(1), MMP1(1), NR1H3(1), PCK1(4), PCK2(1), PLTP(2), PPARD(1), PPARG(1), RXRB(3), RXRG(2), SCP2(2), SLC27A1(2), SLC27A2(1), SLC27A5(2), SLC27A6(5), SORBS1(1), UBC(2), UCP1(1) 39806181 69 62 69 21 5 10 11 31 12 0 0.585 1.000 1.000 530 HSA04340_HEDGEHOG_SIGNALING_PATHWAY Genes involved in Hedgehog signaling pathway BMP2, BMP4, BMP5, BMP6, BMP7, BMP8A, BMP8B, BTRC, CSNK1A1, CSNK1A1L, CSNK1D, CSNK1E, CSNK1G1, CSNK1G2, CSNK1G3, DHH, FBXW11, GAS1, GLI1, GLI2, GLI3, GSK3B, HHIP, IHH, LRP2, PRKACA, PRKACB, PRKACG, PRKX, PRKY, PTCH1, PTCH2, RAB23, SHH, SMO, STK36, SUFU, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT3A, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B, WNT8A, WNT8B, WNT9A, WNT9B, ZIC2 55 BMP2(1), BMP5(1), BMP6(1), BMP7(2), BTRC(2), CSNK1A1(1), CSNK1G1(1), CSNK1G2(1), CSNK1G3(1), FBXW11(1), GLI1(3), GLI2(4), GLI3(3), HHIP(2), LRP2(13), PRKACA(1), PRKACB(4), PRKACG(2), PTCH1(7), PTCH2(1), SHH(1), SMO(3), STK36(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT3A(1), WNT5B(1), WNT7B(1), WNT8A(1) 35583288 67 60 65 21 6 8 7 39 7 0 0.736 1.000 1.000 531 HSA00790_FOLATE_BIOSYNTHESIS Genes involved in folate biosynthesis ALPI, ALPL, ALPP, ALPPL2, ASCC3, ASCC3L1, ATP13A2, DDX18, DDX19A, DDX23, DDX4, DDX41, DDX47, DDX50, DDX51, DDX52, DDX54, DDX55, DDX56, DHFR, DHX58, ENTPD7, EP400, ERCC2, ERCC3, FPGS, GCH1, GGH, IFIH1, MOV10L1, NUDT5, NUDT8, PTS, QDPR, RAD54B, RAD54L, RUVBL2, SETX, SKIV2L2, SMARCA2, SMARCA5, SPR 41 ALPI(2), ALPL(2), ALPP(3), ALPPL2(3), ASCC3(5), ATP13A2(4), DDX18(4), DDX23(2), DDX4(3), DDX47(1), DDX50(5), DDX54(1), DDX55(1), DHX58(1), EP400(5), ERCC2(1), ERCC3(1), FPGS(2), IFIH1(2), MOV10L1(3), QDPR(1), RAD54L(2), RUVBL2(2), SETX(5), SMARCA2(4), SMARCA5(1) 38574277 66 58 66 17 1 18 10 21 16 0 0.227 1.000 1.000 532 HSA04330_NOTCH_SIGNALING_PATHWAY Genes involved in Notch signaling pathway ADAM17, APH1A, CIR, CREBBP, CTBP1, CTBP2, DLL1, DLL3, DLL4, DTX1, DTX2, DTX3, DTX3L, DTX4, DVL1, DVL2, DVL3, EP300, GCN5L2, HDAC1, HDAC2, HES1, JAG1, JAG2, LFNG, LOC652788, MAML1, MAML2, MAML3, MFNG, NCOR2, NCSTN, NOTCH1, NOTCH2, NOTCH3, NOTCH4, NUMB, NUMBL, PCAF, PSEN1, PSEN2, PSENEN, PTCRA, RBPJ, RBPJL, RFNG, SNW1 43 CREBBP(4), CTBP1(1), CTBP2(1), DLL1(1), DLL4(2), DTX1(2), DVL1(1), EP300(6), HDAC1(2), JAG1(1), JAG2(2), MAML1(4), MAML2(2), MAML3(5), NCOR2(4), NCSTN(1), NOTCH1(3), NOTCH2(7), NOTCH3(6), NOTCH4(1), NUMB(2), NUMBL(1), PSEN2(3), PSENEN(1), RBPJ(2), RBPJL(1), SNW1(1) 40444145 67 57 67 24 5 7 13 30 12 0 0.763 1.000 1.000 533 TRANSLATION_FACTORS ANKHD1, ANKHD1, MASK_BP3, EEF1A2, EEF1B2, EEF1D, EEF1G, EEF2, EEF2K, EIF1AX, EIF1AY, EIF2AK1, EIF2AK2, EIF2AK3, EIF2B1, EIF2B2, EIF2B3, EIF2B4, EIF2B5, EIF2S1, EIF2S2, EIF2S3, EIF3S1, EIF3S10, EIF3S2, EIF3S3, EIF3S4, EIF3S5, EIF3S6, EIF3S7, EIF3S8, EIF3S9, EIF4A1, EIF4A2, EIF4E, EIF4EBP1, EIF4EBP2, EIF4G1, EIF4G3, EIF5, EIF5A, EIF5B, ETF1, GSPT2, ITGB4BP, KIAA0664, PABPC1, PABPC3, PABPC1, LOC341315, PAIP1, PAIP1, LOC388345, SLC35A4, SUI1, WBSCR1 37 ANKHD1(3), EEF1A2(1), EEF1D(1), EEF1G(1), EIF2AK1(2), EIF2AK2(4), EIF2AK3(2), EIF2B1(2), EIF2B2(1), EIF2B3(1), EIF2B5(1), EIF2S2(1), EIF4A2(3), EIF4E(1), EIF4G1(2), EIF4G3(3), EIF5(2), EIF5A(2), ETF1(3), KIAA0664(3), PABPC1(9), PABPC3(6), PAIP1(2), SLC35A4(2) 27332007 58 53 58 19 7 11 9 21 10 0 0.582 1.000 1.000 534 HSA00190_OXIDATIVE_PHOSPHORYLATION Genes involved in oxidative phosphorylation ATP12A, ATP4A, ATP4B, ATP5A1, ATP5B, ATP5C1, ATP5D, ATP5E, ATP5F1, ATP5G1, ATP5G2, ATP5G3, ATP5H, ATP5I, ATP5J, ATP5J2, ATP5L, ATP5O, ATP6, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP8, COX1, COX10, COX15, COX17, COX2, COX3, COX4I1, COX4I2, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6B2, COX6C, COX7A1, COX7A2, COX7B, COX7B2, COX7C, COX8A, COX8C, CYC1, CYTB, LHPP, ND1, ND2, ND3, ND4, ND4L, ND5, ND6, NDUFA1, NDUFA10, NDUFA11, NDUFA12, NDUFA13, NDUFA2, NDUFA3, NDUFA4, NDUFA4L2, NDUFA5, NDUFA6, NDUFA7, NDUFA8, NDUFA9, NDUFAB1, NDUFB1, NDUFB10, NDUFB11, NDUFB2, NDUFB3, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFB8, NDUFB9, NDUFC1, NDUFC2, NDUFS1, NDUFS2, NDUFS3, NDUFS4, NDUFS5, NDUFS6, NDUFS7, NDUFS8, NDUFV1, NDUFV2, NDUFV3, PPA1, PPA2, SDHA, SDHB, SDHC, SDHD, TCIRG1, UCRC, UQCR, UQCRB, UQCRC1, UQCRC2, UQCRFS1, UQCRH, UQCRQ 113 ATP12A(4), ATP4A(3), ATP5A1(2), ATP5B(2), ATP5C1(1), ATP5G2(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), COX15(1), COX17(1), COX6A2(1), COX6B2(1), COX7A2(1), NDUFA10(2), NDUFA13(2), NDUFA3(1), NDUFA6(1), NDUFA7(1), NDUFB6(1), NDUFC1(2), NDUFS1(4), NDUFS2(1), NDUFS3(1), NDUFS5(1), NDUFS8(1), NDUFV2(1), PPA2(2), SDHB(1), SDHD(1), UQCRC2(1) 34655460 54 52 54 22 4 6 8 26 10 0 0.941 1.000 1.000 535 HSA05120_EPITHELIAL_CELL_SIGNALING_IN_HELICOBACTER_PYLORI_INFECTION Genes involved in epithelial cell signaling in Helicobacter pylori infection ADAM10, ADAM17, ATP6AP1, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, CASP3, CCL5, CDC42, CHUK, CSK, CXCL1, EGFR, F11R, GIT1, HBEGF, IGSF5, IKBKB, IKBKG, IL8, IL8RA, IL8RB, JAM2, JAM3, JUN, LYN, MAP2K4, MAP3K14, MAPK10, MAPK11, MAPK12, MAPK13, MAPK14, MAPK8, MAPK9, MET, NFKB1, NFKB2, NFKBIA, NOD1, PAK1, PLCG1, PLCG2, PTPN11, PTPRZ1, RAC1, RELA, SRC, TCIRG1, TJP1 65 ADAM10(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), CDC42(1), CHUK(1), CSK(2), EGFR(7), F11R(1), GIT1(2), JUN(2), MAP3K14(1), MAPK10(1), MAPK12(1), MAPK13(1), MAPK14(1), MAPK9(2), MET(3), NFKB1(1), NOD1(1), PAK1(1), PLCG2(1), PTPN11(1), PTPRZ1(8), RAC1(1), RELA(1), SRC(2), TJP1(2) 43767104 61 51 60 20 3 11 9 30 8 0 0.775 1.000 1.000 536 WNT_SIGNALING Wnt signaling genes APC, ARHA, AXIN1, C2orf31, CCND1, CCND2, CCND3, CSNK1E, CSNK1E, LOC400927, CTNNB1, DIPA, DVL1, DVL2, DVL3, FBXW2, FOSL1, FRAT1, FZD1, FZD10, FZD2, FZD3, FZD5, FZD6, FZD7, FZD8, FZD9, GSK3B, JUN, LDLR, MAPK10, MAPK9, MYC, PAFAH1B1, PLAU, PPP2R5C, PPP2R5E, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCI, PRKCM, PRKCQ, PRKCZ, PRKD1, RAC1, RHOA, SFRP4, TCF7, WNT1, WNT10A, WNT10B, WNT11, WNT16, WNT2, WNT2B, WNT3, WNT4, WNT5A, WNT5B, WNT6, WNT7A, WNT7B 58 APC(6), AXIN1(2), CCND2(1), CTNNB1(1), DVL1(1), FZD1(2), FZD10(2), FZD3(1), FZD5(1), JUN(2), LDLR(1), MAPK10(1), MAPK9(2), MYC(1), PAFAH1B1(1), PLAU(4), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCI(1), PRKCQ(3), PRKCZ(2), PRKD1(3), RAC1(1), SFRP4(2), WNT10A(1), WNT11(2), WNT2(1), WNT3(1), WNT5B(1), WNT7B(1) 35605677 55 51 55 22 5 11 6 26 7 0 0.817 1.000 1.000 537 HIVNEFPATHWAY HIV-infected CD4 helper T cells may express Fas ligand, which binds to the Fas receptors of uninfected cells and induces apoptosis. ACTG1, ADPRT, APAF1, ARHGDIB, BAG4, BCL2, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CDC2L1, CDC2L2, CFLAR, CHUK, CRADD, CYCS, DAXX, DFFA, DFFB, FADD, GSN, LMNA, LMNB1, LMNB2, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK8, MDM2, NFKB1, NFKBIA, NUMA1, PAK2, PRKCD, PRKDC, PSEN1, PSEN2, PTK2, RASA1, RB1, RELA, RIPK1, SPTAN1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRADD, TRAF1, TRAF2 52 ACTG1(2), ARHGDIB(1), BAG4(1), BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), CFLAR(1), CHUK(1), DAXX(4), GSN(1), LMNB1(1), MAP2K7(1), MAP3K1(4), MAP3K14(1), MAP3K5(5), NFKB1(1), NUMA1(1), PRKCD(2), PRKDC(5), PSEN2(3), PTK2(1), RASA1(3), RB1(1), RELA(1), RIPK1(1), SPTAN1(5), TNFRSF1A(1), TRADD(1) 42948439 57 50 57 19 2 15 7 25 8 0 0.652 1.000 1.000 538 KERATINOCYTEPATHWAY Keratinocyte differentiation, which models the differentiation of epidermal cells, requires the four main MAP kinase pathways. BCL2, CEBPA, CHUK, DAXX, EGF, EGFR, ETS1, ETS2, FOS, HOXA7, HRAS, IKBKB, JUN, MAP2K1, MAP2K3, MAP2K4, MAP2K6, MAP2K7, MAP3K1, MAP3K14, MAP3K5, MAPK1, MAPK13, MAPK14, MAPK3, MAPK8, NFKB1, NFKBIA, PPP2CA, PRKCA, PRKCB1, PRKCD, PRKCE, PRKCG, PRKCH, PRKCQ, RAF1, RELA, RIPK1, SP1, TNF, TNFRSF1A, TNFRSF1B, TNFRSF6, TNFSF6, TRAF2 42 CHUK(1), DAXX(4), EGF(4), EGFR(7), HRAS(1), JUN(2), MAP2K3(3), MAP2K6(1), MAP2K7(1), MAP3K1(4), MAP3K14(1), MAP3K5(5), MAPK13(1), MAPK14(1), MAPK3(1), NFKB1(1), PPP2CA(1), PRKCD(2), PRKCE(2), PRKCG(1), PRKCH(2), PRKCQ(3), RELA(1), RIPK1(1), TNFRSF1A(1) 30112622 52 50 51 17 5 5 3 25 14 0 0.812 1.000 1.000 539 HSA00380_TRYPTOPHAN_METABOLISM Genes involved in tryptophan metabolism AADAT, AANAT, ABP1, ACAT1, ACAT2, ACMSD, AFMID, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CARM1, CAT, CYP1A1, CYP1A2, CYP1B1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADH, HADHA, HEMK1, HSD17B10, HSD17B4, INDO, INDOL1, INMT, KMO, KYNU, LCMT1, LCMT2, LNX1, MAOA, MAOB, METTL2B, METTL6, NFX1, OGDH, OGDHL, PRMT2, PRMT3, PRMT5, PRMT6, PRMT7, PRMT8, TDO2, TPH1, TPH2, WARS, WARS2, WBSCR22 58 ABP1(5), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(2), AOC3(1), AOX1(7), CAT(2), CYP1A1(1), CYP1A2(3), DDC(2), ECHS1(2), EHHADH(2), HADH(1), HADHA(1), HSD17B4(1), LCMT1(1), LCMT2(3), MAOA(1), NFX1(1), OGDH(3), OGDHL(2), PRMT3(2), PRMT5(1), PRMT6(1), PRMT7(1), PRMT8(1), TPH1(1), TPH2(1), WARS2(1) 37332426 56 49 56 16 4 11 9 25 7 0 0.505 1.000 1.000 540 HSA01031_GLYCAN_STRUCTURES_BIOSYNTHESIS_2 Genes involved in glycan structures - biosynthesis 2 A4GALT, ABO, B3GALNT1, B3GALT1, B3GALT2, B3GALT4, B3GALT5, B3GNT1, B3GNT2, B3GNT3, B3GNT4, B3GNT5, B4GALNT1, B4GALT1, B4GALT2, B4GALT3, B4GALT4, B4GALT6, FUT1, FUT2, FUT3, FUT4, FUT5, FUT6, FUT7, FUT9, GBGT1, GCNT2, PIGA, PIGB, PIGC, PIGF, PIGG, PIGH, PIGK, PIGL, PIGM, PIGN, PIGO, PIGP, PIGQ, PIGS, PIGT, PIGU, PIGV, PIGX, PIGZ, ST3GAL1, ST3GAL2, ST3GAL3, ST3GAL4, ST3GAL5, ST3GAL6, ST6GALNAC3, ST6GALNAC4, ST6GALNAC5, ST6GALNAC6, ST8SIA1, ST8SIA5, UGCG, UGCGL1, UGCGL2 60 ABO(1), B3GALT2(2), B3GALT4(1), B3GNT2(2), B3GNT3(1), B3GNT5(1), B4GALT3(1), B4GALT4(2), B4GALT6(1), FUT1(1), FUT6(1), GBGT1(2), GCNT2(4), PIGB(1), PIGC(1), PIGG(1), PIGK(1), PIGL(2), PIGM(1), PIGN(1), PIGO(1), PIGP(1), PIGQ(5), PIGS(1), PIGT(2), PIGU(1), PIGV(1), PIGZ(1), ST3GAL1(1), ST3GAL3(1), ST3GAL5(1), ST3GAL6(1), ST6GALNAC3(2), ST6GALNAC5(1), ST8SIA1(2), ST8SIA5(1) 29538729 51 48 51 17 5 8 8 19 10 1 0.670 1.000 1.000 541 APOPTOSIS APAF1, BAD, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BCL2L11, BID, BIRC2, BIRC3, BIRC4, BIRC5, BNIP3L, CASP1, CASP10, CASP1, COPl, CASP2, CASP3, CASP4, CASP6, CASP7, CASP8, CASP9, CHUK, CYCS, DFFA, DFFB, FADD, FAS, FASLG, GZMB, HELLS, HRK, IKBKB, IKBKG, IRF1, IRF2, IRF3, IRF4, IRF5, IRF6, IRF7, JUN, LTA, MAP2K4, MAP3K1, MAPK10, MDM2, MYC, NFKB1, NFKBIA, NFKBIB, NFKBIE, PRF1, RELA, RIPK1, TNF, TNFRSF10B, TNFRSF1A, TNFRSF1B, TNFRSF21, TNFRSF25, TNFRSF25, PLEKHG5, TNFSF10, TP53, TP73, TRADD, TRAF1, TRAF2, TRAF3 66 BID(1), BIRC2(3), BIRC3(2), CASP1(1), CASP10(3), CASP2(1), CASP7(1), CHUK(1), FAS(1), FASLG(1), HELLS(2), JUN(2), LTA(1), MAP3K1(4), MAPK10(1), MYC(1), NFKB1(1), NFKBIB(1), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TP73(3), TRADD(1), TRAF3(1) 34651207 48 47 48 15 2 8 7 21 10 0 0.607 1.000 1.000 542 ARGININE_AND_PROLINE_METABOLISM ABP1, AGMAT, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH4A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS, CKB, CKM, CKMT1, CKMT1B, CKMT1A, CKMT2, CPS1, DAO, GAMT, GATM, GLUD1, GOT1, GOT2, MAOA, MAOB, NOS1, NOS2A, NOS3, OAT, ODC1, OTC, P4HA1, P4HA2, P4HA3, P4HB, PYCR1, RARS, SAT, SMS 43 ABP1(5), AGMAT(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH4A1(1), AOC2(2), AOC3(1), ARG1(1), ASL(1), CPS1(5), DAO(1), GATM(2), GOT1(2), GOT2(2), MAOA(1), NOS1(8), NOS3(2), ODC1(1), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PYCR1(1), SMS(2) 27134161 52 47 52 19 2 4 13 24 9 0 0.805 1.000 1.000 543 FCER1PATHWAY In mast cells, Fc epsilon receptor 1 activates BTK, PKC, and the MAP kinase pathway to promote degranulation and arachnidonic acid release. BTK, CALM1, CALM2, CALM3, ELK1, FCER1A, FCER1G, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP2K4, MAP2K7, MAP3K1, MAPK1, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PAK2, PIK3CA, PIK3R1, PLA2G4A, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCB1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 37 BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP2K7(1), MAP3K1(4), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PIK3CA(12), PIK3R1(2), PLA2G4A(1), PPP3CA(1), PPP3CC(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2) 25935673 50 47 47 16 5 12 6 21 6 0 0.516 1.000 1.000 544 HSA05130_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EHEC Genes involved in pathogenic Escherichia coli infection - EHEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6) 31677284 52 46 52 23 3 12 9 22 6 0 0.917 1.000 1.000 545 HSA05131_PATHOGENIC_ESCHERICHIA_COLI_INFECTION_EPEC Genes involved in pathogenic Escherichia coli infection - EPEC ABL1, ACTB, ACTG1, ARHGEF2, ARPC5, ARPC5L, CD14, CDC42, CDH1, CLDN1, CTNNB1, CTTN, EZR, FYN, HCLS1, ITGB1, KRT18, LOC643224, LOC654264, LY96, NCK1, NCK2, NCL, OCLN, PRKCA, RHOA, ROCK1, ROCK2, TLR4, TLR5, TUBA1A, TUBA1B, TUBA1C, TUBA3C, TUBA3D, TUBA3E, TUBA4A, TUBA8, TUBAL3, TUBB, TUBB1, TUBB2A, TUBB2B, TUBB2C, TUBB3, TUBB4, TUBB4Q, TUBB6, TUBB8, WAS, WASL, YWHAQ, YWHAZ 51 ABL1(4), ACTG1(2), ARPC5L(1), CDC42(1), CDH1(2), CTNNB1(1), FYN(1), HCLS1(1), ITGB1(3), LY96(1), NCL(3), ROCK1(4), ROCK2(3), TLR4(2), TLR5(2), TUBA1A(1), TUBA4A(2), TUBAL3(2), TUBB(2), TUBB1(2), TUBB2B(2), TUBB3(3), TUBB4(1), WASL(6) 31677284 52 46 52 23 3 12 9 22 6 0 0.917 1.000 1.000 546 HSA00970_AMINOACYL_TRNA_BIOSYNTHESIS Genes involved in aminoacyl-tRNA biosynthesis AARS, AARS2, CARS, CARS2, DARS, DARS2, EARS2, EPRS, FARS2, FARSA, FARSB, GARS, HARS, HARS2, IARS, IARS2, KARS, LARS, LARS2, MARS, MARS2, MTFMT, NARS, NARS2, PARS2, QARS, RARS, RARS2, SARS, SARS2, TARS, TARS2, VARS, VARS2, WARS, WARS2, YARS, YARS2 38 AARS(1), AARS2(1), CARS(4), CARS2(2), DARS(1), EPRS(2), FARSA(1), HARS(1), HARS2(1), IARS(4), IARS2(2), KARS(1), LARS(1), LARS2(1), MARS(2), MARS2(3), NARS2(4), PARS2(2), SARS(3), TARS(2), TARS2(3), VARS(2), VARS2(1), WARS2(1), YARS(1) 32597040 47 45 47 13 1 9 6 25 6 0 0.457 1.000 1.000 547 STARCH_AND_SUCROSE_METABOLISM AGL, AMY1A, AMY1B, AMY1C, AMY2A, AMY2B, AMY2B, RNPC3, ENPP1, ENPP3, G6PC, GAA, GANAB, GBA3, GBE1, GCK, GPI, GUSB, GYS1, GYS2, HK1, HK2, HK3, MGAM, PGM1, PGM3, PYGB, PYGL, PYGM, SI, UCHL1, UCHL3, UGDH, UGT1A10, UGT1A10, UGT1A8, UGT1A7, UGT1A6, UGT1A5, UGT1A9, UGT1A4, UGT1A1, UGT1A3, UGT1A6, UGT1A8, UGT1A9, UGT2B15, UGT2B4, UXS1 41 AGL(4), AMY2A(1), AMY2B(1), ENPP3(1), G6PC(2), GAA(1), GBA3(2), GBE1(1), GUSB(6), GYS1(1), GYS2(1), HK1(4), MGAM(2), PYGB(2), PYGL(1), PYGM(2), RNPC3(1), SI(6), UCHL3(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2B15(1), UGT2B4(2), UXS1(1) 35652492 52 45 50 15 4 6 11 19 12 0 0.494 1.000 1.000 548 HSA00980_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 Genes involved in metabolism of xenobiotics by cytochrome P450 ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH6, ADH7, ADHFE1, AKR1C1, AKR1C2, AKR1C3, AKR1C4, ALDH1A3, ALDH3A1, ALDH3B1, ALDH3B2, CYP1A1, CYP1A2, CYP1B1, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2F1, CYP2S1, CYP3A4, CYP3A43, CYP3A5, CYP3A7, DHDH, EPHX1, GSTA1, GSTA2, GSTA3, GSTA4, GSTA5, GSTK1, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, MGST1, MGST2, MGST3, UGT1A1, UGT1A10, UGT1A3, UGT1A4, UGT1A5, UGT1A6, UGT1A7, UGT1A8, UGT1A9, UGT2A1, UGT2A3, UGT2B10, UGT2B11, UGT2B15, UGT2B17, UGT2B28, UGT2B4, UGT2B7 70 ADH1A(2), ADH1B(1), ADH4(1), ADH5(1), ADHFE1(2), AKR1C1(1), ALDH3B1(1), ALDH3B2(2), CYP1A1(1), CYP1A2(3), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP3A7(1), DHDH(3), EPHX1(4), GSTA3(1), GSTA4(1), GSTM1(1), UGT1A4(2), UGT1A6(1), UGT1A7(3), UGT1A8(2), UGT2A1(3), UGT2A3(2), UGT2B11(2), UGT2B15(1), UGT2B28(1), UGT2B4(2), UGT2B7(2) 35849687 50 44 49 17 5 6 7 21 11 0 0.766 1.000 1.000 549 INTEGRINPATHWAY Integrins are cell surface receptors commonly present at focal adhensions that interact with the extracellular matrix and transduce extracellular signaling. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, BCAR1, BCR, CAPN1, CAPNS1, CAPNS2, CAV1, CRKL, CSK, FYN, GRB2, GRF2, HRAS, ITGA1, ITGB1, JUN, MAP2K1, MAP2K2, MAPK1, MAPK3, MAPK8, PPP1R12B, PTK2, PXN, RAF1, RAP1A, ROCK1, SHC1, SOS1, SRC, TLN1, TNS, VCL, ZYX 35 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), BCR(1), CAPN1(2), CSK(2), FYN(1), GRB2(1), HRAS(1), ITGA1(3), ITGB1(3), JUN(2), MAPK3(1), PTK2(1), RAP1A(1), ROCK1(4), SHC1(2), SOS1(6), SRC(2), TLN1(4), VCL(2), ZYX(1) 28961613 48 44 48 15 5 8 2 24 9 0 0.737 1.000 1.000 550 ST_T_CELL_SIGNAL_TRANSDUCTION On activation of the T cell receptor, phospholipase C is activated to produce second messengers DAG and PIP3, both required for T cell activation. CBL, CD28, CD3D, CSK, CTLA4, DAG1, DTYMK, EPHB2, FBXW7, GRAP2, GRB2, ITK, ITPKA, ITPKB, LAT, LCK, LCP2, MAPK1, NCK1, NFAT5, NFKB1, NFKB2, NFKBIA, NFKBIB, NFKBIE, NFKBIL1, NFKBIL2, PAG, PAK1, PAK2, PAK3, PAK4, PAK6, PAK7, PLCG1, PTPRC, RAF1, RASGRP1, RASGRP2, RASGRP3, RASGRP4, SOS1, SOS2, VAV1, ZAP70 44 CBL(1), CD28(1), CSK(2), EPHB2(1), FBXW7(1), GRAP2(1), GRB2(1), ITK(1), ITPKA(1), ITPKB(1), LCP2(1), NFAT5(7), NFKB1(1), NFKBIB(1), NFKBIL1(1), PAK1(1), PAK4(2), PAK6(4), PAK7(1), PTPRC(6), RASGRP2(2), RASGRP3(1), RASGRP4(2), SOS1(6), SOS2(1), VAV1(2) 34244885 50 44 49 17 6 9 4 25 6 0 0.735 1.000 1.000 551 DNA_REPLICATION_REACTOME ASK, CDC45L, CDC6, CDC7, CDK2, CDT1, DIAPH2, GMNN, MCM10, MCM2, MCM3, MCM4, MCM5, MCM6, MCM7, NACA, NACA, FKSG17, ORC1L, ORC2L, ORC3L, ORC4L, ORC5L, ORC6L, PCNA, POLA, POLA2, POLD1, POLD2, POLD3, POLD4, POLE, POLE2, PRIM1, PRIM2A, RFC1, RFC2, RFC3, RFC4, RFC5, RPA1, RPA2, RPA3, RPA4, RPS27A, RPS27A, LOC388720, LOC389425, UBA52, UBB, UBC 42 CDC7(1), CDK2(2), CDT1(1), DIAPH2(2), MCM10(1), MCM2(3), MCM5(1), MCM6(2), MCM7(4), NACA(1), ORC1L(1), ORC2L(1), PCNA(3), POLD1(3), POLD3(1), POLE(4), POLE2(1), PRIM1(2), RFC1(4), RFC2(1), RFC4(1), RFC5(1), RPA2(1), RPA3(1), RPA4(1), RPS27A(1), UBC(2) 31494222 47 43 47 17 3 6 6 22 10 0 0.785 1.000 1.000 552 TRYPTOPHAN_METABOLISM AANAT, ABP1, ACAT1, ACAT2, ACMSD, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, AOC2, AOC3, AOX1, ASMT, CAT, CYP19A1, CYP1A1, CYP1A2, CYP2A6, CYP2A6, CYP2A7, CYP2A7P1, CYP2A13, CYP2B6, CYP2C18, CYP2C19, CYP2C19, CYP2C9, CYP2C8, CYP2C9, CYP2D6, CYP2E1, CYP2F1, CYP2J2, CYP3A4, CYP3A5, CYP3A7, CYP4B1, CYP4F8, CYP51A1, DDC, ECHS1, EHHADH, GCDH, HAAO, HADHA, INDO, KMO, KYNU, MAOA, MAOB, SDS, TDO2, TPH1, WARS, WARS2 54 ABP1(5), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), AOC2(2), AOC3(1), AOX1(7), CAT(2), CYP19A1(2), CYP1A1(1), CYP1A2(3), CYP2A13(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP3A7(1), CYP4B1(3), DDC(2), ECHS1(2), EHHADH(2), HADHA(1), MAOA(1), TPH1(1), WARS2(1) 33897692 51 43 51 19 4 10 6 26 5 0 0.776 1.000 1.000 553 GLYCOLYSIS_AND_GLUCONEOGENESIS Genes involved in glycolysis and gluconeogenesis ALDOA, ALDOB, ALDOC, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GAPDHS, GAPDS, GCK, GOT1, GOT2, GPI, HK1, HK2, HK3, LDHA, LDHAL6B, LDHB, LDHC, MDH1, MDH2, PC, PCK1, PDHA1, PDHA2, PDHB, PDHX, PFKL, PFKM, PFKP, PGAM1, PGAM2, PGK1, PGK2, PKLR, PKM2, TNFAIP1, TPI1 43 ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), GAPDHS(1), GOT1(2), GOT2(2), HK1(4), LDHAL6B(1), LDHB(1), LDHC(1), MDH1(1), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PFKL(1), PFKM(2), PGAM1(1), PGAM2(1), PGK1(2), PKM2(1), TNFAIP1(1), TPI1(1) 26101135 47 42 47 15 2 4 6 17 18 0 0.748 1.000 1.000 554 HSA00564_GLYCEROPHOSPHOLIPID_METABOLISM Genes involved in glycerophospholipid metabolism ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, ARD1A, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHPT1, CRLS1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKI, DGKQ, DGKZ, ESCO1, ESCO2, ETNK1, ETNK2, GNPAT, GPAM, GPD1, GPD1L, GPD2, LCAT, LYCAT, LYPLA1, LYPLA2, LYPLA3, MYST3, MYST4, NAT5, NAT6, PCYT1A, PCYT1B, PEMT, PHOSPHO1, PISD, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PNPLA3, PPAP2A, PPAP2B, PPAP2C, PTDSS1, PTDSS2, SH3GLB1 64 ACHE(1), AGPAT6(1), CDS2(1), CHKB(1), CHPT1(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ESCO1(2), ESCO2(1), ETNK1(2), GPAM(1), LCAT(1), LYPLA1(1), MYST3(4), MYST4(4), PCYT1B(1), PISD(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PNPLA3(2), PPAP2B(1), PPAP2C(2), PTDSS1(2), SH3GLB1(1) 40535957 47 42 47 11 6 5 9 22 5 0 0.239 1.000 1.000 555 GLUCONEOGENESIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1) 30105215 47 41 46 17 4 2 5 22 14 0 0.905 1.000 1.000 556 GLYCOLYSIS ACYP1, ACYP2, ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AKR1A1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH3B1, ALDH3B2, ALDH9A1, ALDOA, ALDOB, ALDOC, BPGM, DLAT, DLD, ENO1, ENO2, ENO3, FBP1, FBP2, G6PC, GAPDH, GCK, GPI, HK1, HK2, HK3, LDHA, LDHB, LDHC, PDHA1, PDHA2, PDHB, PFKM, PFKP, PGAM1, PGK1, PGM1, PGM3, PKLR, PKM2, TPI1 53 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH3B1(1), ALDH3B2(2), ALDOA(2), ALDOB(3), DLAT(2), DLD(2), ENO1(2), ENO2(1), FBP1(1), G6PC(2), HK1(4), LDHB(1), LDHC(1), PDHA1(1), PDHA2(1), PDHB(1), PFKM(2), PGAM1(1), PGK1(2), PKM2(1), TPI1(1) 30105215 47 41 46 17 4 2 5 22 14 0 0.905 1.000 1.000 557 HSA00640_PROPANOATE_METABOLISM Genes involved in propanoate metabolism ABAT, ACACA, ACACB, ACADM, ACAT1, ACAT2, ACSS1, ACSS2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH7A1, ALDH9A1, ECHS1, EHHADH, HADHA, HIBCH, LDHA, LDHAL6A, LDHAL6B, LDHB, LDHC, LOC283398, MCEE, MLYCD, MUT, PCCA, PCCB, SUCLA2, SUCLG1, SUCLG2 33 ABAT(1), ACACA(4), ACACB(3), ACADM(1), ACSS1(3), ACSS2(3), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), ECHS1(2), EHHADH(2), HADHA(1), LDHAL6B(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1) 24582680 42 41 42 13 2 5 12 14 9 0 0.590 1.000 1.000 558 PEPTIDE_GPCRS AGTR1, AGTR2, ATP8A1, AVPR1A, AVPR1B, AVPR2, BDKRB1, BDKRB2, BLR1, BRS3, C3AR1, C5R1, CCKAR, CCKBR, CCR1, CCR10, CCR2, CCR3, CCR4, CCR5, CCR6, CCR7, CCR8, CX3CR1, CXCR3, CXCR4, CXCR6, EDNRA, EDNRB, ELA3A, FPR1, FPRL1, FPRL2, FSHR, FY, GALR1, GALR2, GALR3, GALT, GHSR, GNB2L1, GNRHR, GPR77, GRPR, IL8RA, IL8RB, LHCGR, MC1R, MC2R, MC3R, MC4R, MC5R, NMBR, NPY1R, NPY2R, NPY5R, NPY6R, NTSR1, NTSR2, OPRD1, OPRK1, OPRL1, OPRM1, OXTR, PPYR1, SSTR1, SSTR2, SSTR3, SSTR4, TAC4, TACR1, TACR2, TACR3, TRHR, TSHR 66 AGTR1(1), ATP8A1(1), AVPR1A(1), AVPR2(2), BDKRB1(1), BDKRB2(1), BRS3(1), C3AR1(1), CCKAR(2), CCKBR(2), CCR6(1), CXCR4(1), CXCR6(1), EDNRB(1), FPR1(1), GALR1(1), GALT(2), GPR77(1), MC2R(2), MC3R(2), MC4R(1), MC5R(1), NMBR(1), NPY1R(1), NTSR1(1), OPRD1(2), OPRM1(2), SSTR1(2), SSTR3(1), SSTR4(1), TACR1(2), TACR2(1), TACR3(2), TRHR(2) 31235819 46 40 46 16 11 5 5 20 5 0 0.517 1.000 1.000 559 CARM_ERPATHWAY Methyltransferase CARM1 methylates CBP and co-activates estrogen receptors via Grip1. BRCA1, CARM1, CCND1, CREBBP, EP300, ERCC3, ESR1, GRIP1, GTF2A1, GTF2E1, GTF2F1, HDAC1, HDAC2, HDAC3, HDAC4, HDAC5, HDAC6, HIST2H3C, MEF2C, NCOR2, NR0B1, NRIP1, PELP1, POLR2A, PPARBP, PPARGC1, REA, SHARP, SRA1, TBP 25 BRCA1(6), CREBBP(4), EP300(6), ERCC3(1), GTF2A1(1), GTF2F1(1), HDAC1(2), HDAC4(1), HDAC6(2), NCOR2(4), NRIP1(6), PELP1(1), POLR2A(6), SRA1(1), TBP(1) 28772970 43 39 43 14 0 7 10 20 6 0 0.529 1.000 1.000 560 HSA00330_ARGININE_AND_PROLINE_METABOLISM Genes involved in arginine and proline metabolism ALDH4A1, ARG1, ARG2, ASL, ASS1, CKB, CKM, CKMT1A, CKMT1B, CKMT2, CPS1, DAO, EPRS, GAMT, GATM, GLUD1, GLUD2, GOT1, GOT2, LAP3, NOS1, NOS2A, NOS3, OAT, OTC, P4HA1, P4HA2, P4HA3, PARS2, PRODH, PYCR1, PYCR2, PYCRL, RARS, RARS2 34 ALDH4A1(1), ARG1(1), ASL(1), ASS1(2), CPS1(5), DAO(1), EPRS(2), GATM(2), GOT1(2), GOT2(2), LAP3(2), NOS1(8), NOS3(2), OTC(1), P4HA1(2), P4HA2(1), P4HA3(1), PARS2(2), PRODH(1), PYCR1(1), PYCR2(1) 22160264 41 39 41 15 2 3 11 18 7 0 0.762 1.000 1.000 561 HSA00512_O_GLYCAN_BIOSYNTHESIS Genes involved in O-glycan biosynthesis B3GNT6, B4GALT5, C1GALT1, C1GALT1C1, GALNT1, GALNT10, GALNT11, GALNT12, GALNT13, GALNT14, GALNT17, GALNT2, GALNT3, GALNT4, GALNT5, GALNT6, GALNT7, GALNT8, GALNT9, GALNTL1, GALNTL2, GALNTL4, GALNTL5, GCNT1, GCNT3, GCNT4, OGT, ST3GAL1, ST3GAL2, ST6GALNAC1, WBSCR17 30 B3GNT6(1), B4GALT5(1), GALNT1(1), GALNT10(1), GALNT11(3), GALNT13(3), GALNT14(1), GALNT2(1), GALNT5(5), GALNT6(1), GALNT7(5), GALNT9(1), GALNTL2(1), GALNTL4(1), GALNTL5(2), GCNT1(2), GCNT4(1), OGT(4), ST3GAL1(1), ST6GALNAC1(1), WBSCR17(4) 20081807 41 39 41 15 1 6 8 20 6 0 0.845 1.000 1.000 562 HSA00590_ARACHIDONIC_ACID_METABOLISM Genes involved in arachidonic acid metabolism AKR1C3, ALOX12, ALOX12B, ALOX15, ALOX15B, ALOX5, CBR1, CBR3, CYP2B6, CYP2C18, CYP2C19, CYP2C8, CYP2C9, CYP2E1, CYP2J2, CYP2U1, CYP4A11, CYP4A22, CYP4F2, CYP4F3, DHRS4, EPHX2, GGT1, GGTL3, GGTL4, GPX1, GPX2, GPX3, GPX4, GPX5, GPX6, GPX7, LTA4H, LTC4S, PGDS, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PTGDS, PTGES, PTGES2, PTGIS, PTGS1, PTGS2, TBXAS1 51 ALOX15B(2), ALOX5(2), CBR1(2), CYP2B6(1), CYP2C19(1), CYP2E1(1), CYP2J2(2), CYP2U1(1), CYP4A11(4), CYP4A22(1), CYP4F2(1), DHRS4(1), EPHX2(1), GGT1(2), GPX3(2), GPX4(1), GPX6(1), LTA4H(4), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PTGDS(1), PTGES(1), PTGS1(1), PTGS2(4), TBXAS1(1) 24062020 42 39 41 15 5 5 10 16 6 0 0.625 1.000 1.000 563 APOPTOSIS_GENMAPP APAF1, BAK1, BCL2L7P1, BAX, BCL2, BCL2L1, BID, BIRC2, BIRC3, BIRC4, CASP2, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, FADD, FAS, FASLG, GZMB, IKBKG, JUN, MAP2K4, MAP3K1, MAP3K14, MAPK10, MCL1, MDM2, MYC, NFKB1, NFKBIA, PARP1, PRF1, RELA, RIPK1, TNF, TNFRSF1A, TNFRSF1B, TNFSF10, TP53, TRADD, TRAF1, TRAF2 41 BID(1), BIRC2(3), BIRC3(2), CASP2(1), CASP7(1), FAS(1), FASLG(1), JUN(2), MAP3K1(4), MAP3K14(1), MAPK10(1), MYC(1), NFKB1(1), PARP1(2), PRF1(1), RELA(1), RIPK1(1), TNFRSF1A(1), TNFSF10(1), TP53(10), TRADD(1) 22678554 38 37 38 15 2 8 7 14 7 0 0.826 1.000 1.000 564 OXIDATIVE_PHOSPHORYLATION ATP12A, ATP4B, ATP5E, ATP5O, ATP6AP1, ATP6V0A1, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0C, SHMT1, ATP6V0D1, ATP6V0E, ATP6V1A, ATP6V1B1, ATP6V1B2, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ATP7A, ATP7B, COX10, COX4I1, COX5A, COX5B, COX6A1, COX6A2, COX6B1, COX6C, COX7A1, COX7A2, COX7B, COX7C, COX8A, NDUFA1, NDUFA10, NDUFA11, NDUFA4, NDUFA5, NDUFA8, NDUFB2, NDUFB4, NDUFB5, NDUFB6, NDUFB7, NDUFS1, NDUFS2, NDUFV1, NDUFV2, PP, PPA2, SDHA, SDHA, SDHAL2, SDHB, UQCRB, UQCRC1, UQCRFS1, UQCRH 60 ATP12A(4), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V1A(2), ATP6V1B1(3), ATP6V1B2(2), ATP6V1D(1), ATP7A(1), ATP7B(5), COX6A2(1), COX7A2(1), NDUFA10(2), NDUFB6(1), NDUFS1(4), NDUFS2(1), NDUFV2(1), PPA2(2), SDHB(1), SHMT1(2) 23852880 37 37 37 15 1 7 6 17 6 0 0.874 1.000 1.000 565 EDG1PATHWAY The lipid S1P is an EDG1 ligand promoting chemotaxis via Rac1 and cell survival and proliferation via ERK activation. ADCY1, AKT1, ARHA, ASAH1, EDG1, GNAI1, GNB1, GNGT1, ITGAV, ITGB3, MAPK1, MAPK3, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB1, PRKCA, PRKCB1, PTK2, RAC1, SKIP, SMPD1, SMPD2, SPHK1, SRC 22 ADCY1(1), AKT1(2), ASAH1(1), GNAI1(1), GNB1(2), ITGB3(1), MAPK3(1), PDGFRA(7), PIK3CA(12), PIK3R1(2), PLCB1(1), PTK2(1), RAC1(1), SMPD1(1), SMPD2(2), SRC(2) 16944584 38 36 35 14 1 10 4 16 7 0 0.765 1.000 1.000 566 GLYCEROLIPID_METABOLISM ADH1A, ADH1A, ADH1B, ADH1C, ADH1B, ADH1C, ADH4, ADH6, ADH7, ADHFE1, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AKR1A1, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CEL, DGAT1, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, GK, GLA, GLB1, LCT, LIPC, LIPF, LIPG, LPL, PNLIP, PNLIPRP1, PNLIPRP2, PPAP2A, PPAP2B, PPAP2C 45 ADH1A(2), ADH1B(1), ADH4(1), ADHFE1(2), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), GLB1(4), LCT(2), LIPC(1), LIPF(1), LPL(1), PNLIP(3), PNLIPRP2(1), PPAP2B(1), PPAP2C(2) 29842836 39 36 38 14 5 8 4 15 7 0 0.728 1.000 1.000 567 HSA00510_N_GLYCAN_BIOSYNTHESIS Genes involved in N-glycan biosynthesis ALG1, ALG10, ALG10B, ALG11, ALG12, ALG13, ALG14, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, B4GALT1, B4GALT2, B4GALT3, DAD1, DDOST, DHDDS, DOLPP1, DPAGT1, DPM1, FUT8, GANAB, GCS1, MAN1A1, MAN1A2, MAN1B1, MAN1C1, MAN2A1, MGAT1, MGAT2, MGAT3, MGAT4A, MGAT4B, MGAT5, MGAT5B, RFT1, RPN1, RPN2, ST6GAL1, STT3B 41 ALG10(2), ALG10B(2), ALG12(1), ALG13(3), ALG14(1), ALG3(1), ALG5(1), ALG6(1), ALG8(2), B4GALT3(1), DOLPP1(2), DPAGT1(2), DPM1(1), MAN1A1(2), MAN1A2(1), MAN2A1(2), MGAT4A(2), MGAT4B(1), MGAT5(2), MGAT5B(1), RFT1(1), RPN1(2), RPN2(1), STT3B(2) 25918113 37 36 37 12 0 8 1 18 10 0 0.765 1.000 1.000 568 INOSITOL_PHOSPHATE_METABOLISM IMPA1, INPP1, INPP4A, INPP4B, INPP5A, INPPL1, ITPKA, ITPKB, MIOX, OCRL, PIK3C2A, PIK3C2B, PIK3C2G, PIK3CA, PIK3CB, PIK3CG, PIK4CA, PIK4CA, LOC220686, PIP5K2B, PLCB1, PLCB2, PLCB3, PLCB4, PLCD1, PLCG1, PLCG2 23 INPP4A(2), INPP4B(2), INPP5A(1), INPPL1(2), ITPKA(1), ITPKB(1), MIOX(2), OCRL(1), PIK3C2B(3), PIK3C2G(2), PIK3CA(12), PIK3CB(1), PIK3CG(3), PLCB1(1), PLCB2(2), PLCB3(1), PLCB4(4), PLCG2(1) 27910396 42 36 38 16 2 8 3 20 9 0 0.884 1.000 1.000 569 IGF1PATHWAY Growth factor IGF-1 stimulates growth and inhibits apoptosis by activating the MAP kinase pathway in a variety of cell types. CSNK2A1, ELK1, FOS, GRB2, HRAS, IGF1, IGF1R, IRS1, JUN, MAP2K1, MAPK3, MAPK8, PIK3CA, PIK3R1, PTPN11, RAF1, RASA1, SHC1, SOS1, SRF 20 ELK1(1), GRB2(1), HRAS(1), IRS1(3), JUN(2), MAPK3(1), PIK3CA(12), PIK3R1(2), PTPN11(1), RASA1(3), SHC1(2), SOS1(6), SRF(1) 14889071 36 35 33 11 3 13 3 15 2 0 0.408 1.000 1.000 570 HSA00220_UREA_CYCLE_AND_METABOLISM_OF_AMINO_GROUPS Genes involved in urea cycle and metabolism of amino groups ABP1, ACY1, ADC, AGMAT, ALDH18A1, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH7A1, ALDH9A1, AMD1, AOC2, AOC3, ARG1, ARG2, ASL, ASS1, CPS1, GATM, MAOA, MAOB, NAGS, ODC1, OTC, SAT1, SAT2, SMS, SRM 30 ABP1(5), AGMAT(2), ALDH18A1(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), AOC2(2), AOC3(1), ARG1(1), ASL(1), ASS1(2), CPS1(5), GATM(2), MAOA(1), ODC1(1), OTC(1), SAT1(1), SAT2(1), SMS(2) 18081719 35 34 35 13 0 5 8 18 4 0 0.822 1.000 1.000 571 NUCLEAR_RECEPTORS ALK, AR, ESR1, ESR2, ESRRA, HNF4A, NPM1, NR0B1, NR1D2, NR1H2, NR1H3, NR1I2, NR1I3, NR2C2, NR2E1, NR2F1, NR2F2, NR2F6, NR3C1, NR4A1, NR4A2, NR5A1, NR5A2, PGR, PPARA, PPARD, PPARG, RARA, RARB, RARG, ROR1, RORA, RORC, RXRA, RXRB, RXRG, THRA, THRA, NR1D1, THRB, VDR 40 ALK(6), AR(1), ESR2(1), NR1D2(1), NR1H3(1), NR1I2(1), NR1I3(1), NR2C2(1), NR2E1(1), NR2F2(1), NR4A2(1), NR5A2(2), PGR(1), PPARD(1), PPARG(1), RARA(4), RARB(2), RORA(1), RXRB(3), RXRG(2), THRA(2), VDR(1) 24907020 36 34 36 12 3 3 11 12 7 0 0.695 1.000 1.000 572 PYRUVATE_METABOLISM ACACA, ACAS2, ACAS2L, ACAT1, ACAT2, ACYP1, ACYP2, ADH5, AKR1B1, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH9A1, CACH_1, DLAT, DLD, GLO1, GRHPR, HAGH, HAGHL, LDHA, LDHB, LDHC, LDHD, MDH1, MDH2, ME1, ME2, ME3, PC, PCK1, PDHA1, PDHA2, PDHB, PKLR, PKM2 37 ACACA(4), ADH5(1), AKR1B1(2), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), DLAT(2), DLD(2), GRHPR(2), HAGH(1), LDHB(1), LDHC(1), MDH1(1), ME1(1), ME2(2), ME3(2), PC(1), PCK1(4), PDHA1(1), PDHA2(1), PDHB(1), PKM2(1) 22738541 38 34 38 12 0 5 7 14 12 0 0.719 1.000 1.000 573 BCRPATHWAY B cell antigen receptors (BCRs) activate tyrosine kinases and transiently increase tyrosine phosphorylation on binding to antigen. BLNK, BTK, CALM1, CALM2, CALM3, CD79A, CD79B, ELK1, FOS, GRB2, HRAS, JUN, LYN, MAP2K1, MAP3K1, MAPK14, MAPK3, MAPK8, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, RAC1, RAF1, SHC1, SOS1, SYK, SYT1, VAV1 34 BTK(1), CALM2(1), ELK1(1), GRB2(1), HRAS(1), JUN(2), MAP3K1(4), MAPK14(1), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), RAC1(1), SHC1(2), SOS1(6), SYK(1), SYT1(1), VAV1(2) 23043913 36 33 36 19 5 6 4 16 5 0 0.967 1.000 1.000 574 FMLPPATHWAY The fMLP receptor is a G-protein coupled receptor in neutrophils that recognizes formylated bacterial peptides and activates NADPH oxidase. CALM1, CALM2, CALM3, CAMK1, CAMK1G, ELK1, FPR1, GNA15, GNB1, GNGT1, HRAS, MAP2K1, MAP2K2, MAP2K3, MAP2K6, MAP3K1, MAPK1, MAPK14, MAPK3, NCF1, NCF2, NFATC1, NFATC2, NFATC3, NFATC4, NFKB1, NFKBIA, PAK1, PIK3C2G, PLCB1, PPP3CA, PPP3CB, PPP3CC, RAC1, RAF1, RELA, SYT1 37 CALM2(1), CAMK1(1), ELK1(1), FPR1(1), GNA15(1), GNB1(2), HRAS(1), MAP2K3(3), MAP2K6(1), MAP3K1(4), MAPK14(1), MAPK3(1), NCF1(1), NCF2(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), NFKB1(1), PAK1(1), PIK3C2G(2), PLCB1(1), PPP3CA(1), PPP3CC(1), RAC1(1), RELA(1), SYT1(1) 23572453 38 33 38 12 5 5 3 17 8 0 0.659 1.000 1.000 575 GPCRPATHWAY G-protein coupled receptors activate adenylyl cyclase, which converts ATP to cAMP, to activate second messenger pathways. ADCY1, CALM1, CALM2, CALM3, CREB1, ELK1, FOS, GNAI1, GNAQ, GNAS, GNB1, GNGT1, HRAS, JUN, MAP2K1, MAPK3, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKACB, PRKACG, PRKAR1A, PRKAR1B, PRKAR2A, PRKAR2B, PRKCA, PRKCB1, RAF1, RPS6KA3, SYT1 34 ADCY1(1), CALM2(1), ELK1(1), GNAI1(1), GNAS(4), GNB1(2), HRAS(1), JUN(2), MAPK3(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), PRKACB(4), PRKACG(2), PRKAR1A(2), PRKAR2B(1), SYT1(1) 20771360 34 33 34 13 5 4 2 19 4 0 0.861 1.000 1.000 576 HSA00020_CITRATE_CYCLE Genes involved in citrate cycle (TCA cycle) ACLY, ACO1, ACO2, CLYBL, CS, DLD, DLST, FH, IDH1, IDH2, IDH3A, IDH3B, IDH3G, LOC283398, LOC441996, MDH1, MDH2, OGDH, OGDHL, PC, PCK1, PCK2, SDHA, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2 27 ACLY(3), ACO1(4), CLYBL(2), CS(1), DLD(2), IDH1(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), OGDHL(2), PC(1), PCK1(4), PCK2(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1) 18584106 36 33 36 13 3 5 3 18 7 0 0.803 1.000 1.000 577 TELPATHWAY Telomerase is a ribonucleotide protein that adds telomeric repeats to the 3' ends of chromosomes. AKT1, BCL2, EGFR, G22P1, HSPCA, IGF1R, KRAS2, MYC, POLR2A, PPP2CA, PRKCA, RB1, TEP1, TERF1, TERT, TNKS, TP53, XRCC5 15 AKT1(2), EGFR(7), MYC(1), POLR2A(6), PPP2CA(1), RB1(1), TEP1(2), TERT(4), TNKS(1), TP53(10), XRCC5(2) 17383824 37 33 36 12 5 8 7 12 5 0 0.389 1.000 1.000 578 HSA00650_BUTANOATE_METABOLISM Genes involved in butanoate metabolism AACS, AADAC, ABAT, ACADS, ACAT1, ACAT2, ACSM1, AKR1B10, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH5A1, ALDH7A1, ALDH9A1, BDH1, BDH2, DDHD1, ECHS1, EHHADH, GAD1, GAD2, HADH, HADHA, HMGCL, HMGCS1, HMGCS2, HSD17B10, HSD17B4, HSD3B7, ILVBL, L2HGDH, OXCT1, OXCT2, PDHA1, PDHA2, PDHB, PLA1A, PPME1, PRDX6, RDH11, RDH12, RDH13, RDH14 45 AADAC(1), ABAT(1), ACADS(2), AKR1B10(2), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ALDH7A1(1), BDH1(1), BDH2(1), DDHD1(1), ECHS1(2), EHHADH(2), GAD2(1), HADH(1), HADHA(1), HMGCS1(1), HMGCS2(1), HSD17B4(1), ILVBL(1), L2HGDH(1), OXCT1(1), PDHA1(1), PDHA2(1), PDHB(1), RDH11(3) 25117682 34 32 33 12 5 4 5 14 6 0 0.725 1.000 1.000 579 PROPANOATE_METABOLISM ABAT, ACACA, ACADL, ACADM, ACADSB, ACAS2, ACAS2L, ACAT1, ACAT2, ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, ALDH2, ALDH3A1, ALDH3A2, ALDH6A1, ALDH9A1, ECHS1, EHHADH, HADHA, LDHA, LDHB, LDHC, MCEE, MLYCD, MUT, PCCA, PCCB, SDS, SUCLA2, SUCLG1, SUCLG2 31 ABAT(1), ACACA(4), ACADM(1), ALDH1A1(1), ALDH1A2(1), ALDH1B1(1), ALDH2(3), ALDH3A2(1), ECHS1(2), EHHADH(2), HADHA(1), LDHB(1), LDHC(1), MCEE(1), MLYCD(1), MUT(2), PCCA(1), PCCB(2), SUCLG1(5), SUCLG2(1) 20524915 33 32 33 12 2 3 9 13 6 0 0.767 1.000 1.000 580 HSA00600_SPHINGOLIPID_METABOLISM Genes involved in sphingolipid metabolism ARSA, ARSD, ARSE, ASAH1, ASAH3L, B4GALT6, CERK, DEGS1, DEGS2, ENPP7, FVT1, GAL3ST1, GALC, GBA, GLA, GLB1, LCT, NEU1, NEU2, NEU3, NEU4, PHCA, PPAP2A, PPAP2B, PPAP2C, SGMS1, SGMS2, SGPP1, SGPP2, SMPD1, SMPD2, SMPD3, SMPD4, SPHK1, SPHK2, SPTLC1, SPTLC2, UGCG, UGT8 36 ARSD(1), ARSE(1), ASAH1(1), B4GALT6(1), DEGS1(2), ENPP7(1), GAL3ST1(2), GALC(1), GBA(2), GLB1(4), LCT(2), NEU1(1), PPAP2B(1), PPAP2C(2), SGPP1(1), SGPP2(2), SMPD1(1), SMPD2(2), SPHK2(1), SPTLC1(1), UGT8(2) 21162933 32 31 32 11 5 5 5 12 5 0 0.634 1.000 1.000 581 IL6PATHWAY IL-6 binding to its receptor activates JAK kinases and a variety of transcription factors, with effects in neuronal differentiation, bone loss, and inflammation. CEBPB, CSNK2A1, ELK1, FOS, GRB2, HRAS, IL6, IL6R, IL6ST, JAK1, JAK2, JAK3, JUN, MAP2K1, MAPK3, PTPN11, RAF1, SHC1, SOS1, SRF, STAT3 20 ELK1(1), GRB2(1), HRAS(1), IL6ST(3), JAK1(4), JAK2(5), JAK3(3), JUN(2), MAPK3(1), PTPN11(1), SHC1(2), SOS1(6), SRF(1), STAT3(1) 14453573 32 31 32 12 2 4 5 17 4 0 0.860 1.000 1.000 582 PYK2PATHWAY Pyk2 and Rac1 stimulate the JNK cascade and activate MKK3, which activates p38. BCAR1, CALM1, CALM2, CALM3, CRKL, GNAQ, GRB2, HRAS, JUN, MAP2K1, MAP2K2, MAP2K3, MAP2K4, MAP3K1, MAPK1, MAPK14, MAPK3, MAPK8, PAK1, PLCG1, PRKCA, PRKCB1, PTK2B, RAC1, RAF1, SHC1, SOS1, SRC, SYT1 28 BCAR1(3), CALM2(1), GRB2(1), HRAS(1), JUN(2), MAP2K3(3), MAP3K1(4), MAPK14(1), MAPK3(1), PAK1(1), PTK2B(2), RAC1(1), SHC1(2), SOS1(6), SRC(2), SYT1(1) 17464944 32 30 32 13 4 7 1 16 4 0 0.870 1.000 1.000 583 ST_GA12_PATHWAY G-alpha-12 promotes cell survival and proliferation, is involved in the stress response, and activates JNK. BF, BTK, DLG4, EPHB2, F2, F2RL1, F2RL2, F2RL3, JUN, MAP2K5, MAPK1, MAPK7, MAPK8, MYEF2, PLD1, PLD2, PLD3, PTK2, RAF1, RASAL1, SRC, TEC, VAV1 22 BTK(1), DLG4(1), EPHB2(1), F2(3), F2RL1(1), F2RL2(1), JUN(2), MAP2K5(2), PLD1(2), PLD2(2), PLD3(3), PTK2(1), RASAL1(1), SRC(2), TEC(5), VAV1(2) 16974757 30 29 29 12 2 3 5 15 5 0 0.890 1.000 1.000 584 CXCR4PATHWAY CXCR4 is a G-protein coupled receptor that responds to the ligand SDF-1 by activating Ras and PI3 kinase to promote lymphocyte chemotaxis. BCAR1, CRK, CXCL12, CXCR4, GNAI1, GNAQ, GNB1, GNGT1, HRAS, MAP2K1, MAPK1, MAPK3, NFKB1, PIK3C2G, PIK3CA, PIK3R1, PLCG1, PRKCA, PRKCB1, PTK2, PTK2B, PXN, RAF1, RELA 23 BCAR1(3), CXCR4(1), GNAI1(1), GNB1(2), HRAS(1), MAPK3(1), NFKB1(1), PIK3C2G(2), PIK3CA(12), PIK3R1(2), PTK2(1), PTK2B(2), RELA(1) 17319856 30 28 27 15 1 10 3 13 3 0 0.906 1.000 1.000 585 GLYCEROPHOSPHOLIPID_METABOLISM ACHE, AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPS, CDIPT, CDS1, CDS2, CHAT, CHKA, CHKB, CHKB, CPT1B, CLC, DGKA, DGKB, DGKD, DGKE, DGKG, DGKH, DGKQ, DGKZ, ETNK1, GNPAT, GPD1, GPD2, LCAT, LGALS13, LYPLA1, LYPLA2, LYPLA2, LYPLA2P1, LOC388499, LYPLA3, PAFAH1B1, PAFAH2, PCYT1A, PCYT1B, PEMT, PISD, PLA2G1B, PLA2G2A, PLA2G2E, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLCB2, PLCG1, PLCG2, PPAP2A, PPAP2B, PPAP2C 49 ACHE(1), AGPS(1), CDS2(1), CHKB(1), DGKB(2), DGKG(1), DGKH(2), DGKQ(1), DGKZ(2), ETNK1(2), LCAT(1), LYPLA1(1), PAFAH1B1(1), PAFAH2(1), PCYT1B(1), PISD(1), PLA2G4A(1), PLA2G6(2), PLCB2(2), PLCG2(1), PPAP2B(1), PPAP2C(2) 30852637 29 27 29 12 5 6 3 11 4 0 0.745 1.000 1.000 586 UCALPAINPATHWAY Calpains promote formation of integrin adhesion clusters which recruit Rac to enable the formation of mature focal adhesions that do not contain calpain. ACTA1, ACTN1, ACTN2, ACTN3, ARHA, CAPN1, CAPNS1, CAPNS2, ITGA1, ITGB1, ITGB3, PTK2, PXN, RAC1, SPTAN1, SRC, TLN1, VIL2 16 ACTN1(1), ACTN2(3), ACTN3(1), CAPN1(2), ITGA1(3), ITGB1(3), ITGB3(1), PTK2(1), RAC1(1), SPTAN1(5), SRC(2), TLN1(4) 17808646 27 27 27 11 3 4 1 12 7 0 0.932 1.000 1.000 587 HSA05110_CHOLERA_INFECTION Genes involved in cholera - infection ACTG1, ACTG2, ADCY3, ADCY9, AK1, ARF1, ARF3, ARF4, ARF5, ARF6, ARL4D, ATP6V0A1, ATP6V0A2, ATP6V0A4, ATP6V0B, ATP6V0C, ATP6V0D1, ATP6V0D2, ATP6V0E1, ATP6V1A, ATP6V1C1, ATP6V1C2, ATP6V1D, ATP6V1E1, ATP6V1E2, ATP6V1F, ATP6V1G1, ATP6V1G2, ATP6V1G3, ATP6V1H, ERO1L, GNAS, PDIA4, PLCG1, PLCG2, PRKCA, SEC61A1, SEC61A2, SEC61B, SEC61G, TRIM23 41 ACTG1(2), ADCY3(3), ADCY9(3), ARF1(1), ARF3(1), ARF6(1), ATP6V0A1(1), ATP6V0A4(1), ATP6V0B(1), ATP6V0D2(1), ATP6V1A(2), ATP6V1D(1), ERO1L(1), GNAS(4), PLCG2(1), SEC61B(1), TRIM23(2) 22897173 27 26 27 15 1 3 4 14 5 0 0.993 1.000 1.000 588 FRUCTOSE_AND_MANNOSE_METABOLISM AKR1B1, ALDOA, ALDOB, ALDOC, FBP1, FBP2, FPGT, GCK, GMDS, GMPPA, GMPPB, HK1, HK2, HK3, KHK, MPI, PFKFB1, PFKFB3, PFKFB4, PFKM, PFKP, PMM1, PMM2, SORD, TPI1 25 AKR1B1(2), ALDOA(2), ALDOB(3), FBP1(1), FPGT(1), GMPPB(1), HK1(4), KHK(4), MPI(1), PFKFB3(1), PFKM(2), PMM1(1), SORD(2), TPI1(1) 14906325 26 25 26 11 3 2 4 9 8 0 0.875 1.000 1.000 589 KREBS_TCA_CYCLE ACO2, CGI_48, CS, DLAT, DLD, DLST, DLST, DLSTP, FH, IDH2, IDH3A, IDH3B, IDH3G, KIAA1348, MDH1, MDH2, OGDH, PC, PDHA1, PDHA2, PDHB, PDHX, PDK1, PDK2, PDK3, PDK4, PDP2, PPM2C, SDHA, SDHA, SDHAL2, SDHB, SDHC, SDHD, SUCLA2, SUCLG1, SUCLG2, WDR50 30 CS(1), DLAT(2), DLD(2), IDH3B(1), IDH3G(1), MDH1(1), OGDH(3), PC(1), PDHA1(1), PDHA2(1), PDHB(1), PDHX(1), PDK1(1), PDK2(1), PDK3(1), PDP2(1), SDHB(1), SDHD(1), SUCLG1(5), SUCLG2(1) 17658030 28 25 28 11 1 3 4 15 5 0 0.833 1.000 1.000 590 VITCBPATHWAY Vitamin C (ascorbic acid), in addition to its role in collagen modification, serves as an antioxidant and is imported into cells by Svct2 in the brain and Svct1 in intestinal epithelium. COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, P4HB, SLC23A1, SLC23A2, SLC2A1, SLC2A3 11 COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), SLC23A1(4), SLC23A2(1), SLC2A3(2) 16050674 25 24 25 10 3 10 1 8 3 0 0.692 1.000 1.000 591 GALACTOSE_METABOLISM AKR1B1, B4GALT1, B4GALT2, FBP2, G6PC, GAA, GALE, GALK1, GALK2, GALT, GANAB, GCK, GLA, GLB1, HK1, HK2, HK3, LALBA, LCT, MGAM, PFKM, PFKP, PGM1, PGM3 24 AKR1B1(2), G6PC(2), GAA(1), GALE(1), GALK1(1), GALK2(1), GALT(2), GLB1(4), HK1(4), LALBA(1), LCT(2), MGAM(2), PFKM(2) 19923975 25 23 25 10 2 2 4 10 7 0 0.868 1.000 1.000 592 IL22BPPATHWAY IL-22 is produced by T cells and induces the acute phase inflammatory response in hepatocytes. IL10RA, IL22, IL22RA1, IL22RA2, JAK1, JAK2, JAK3, SOCS3, STAT1, STAT3, STAT5A, STAT5B, TYK2 13 IL22(1), IL22RA1(1), JAK1(4), JAK2(5), JAK3(3), STAT1(4), STAT3(1), STAT5B(1), TYK2(3) 11362682 23 23 23 12 1 0 4 14 4 0 0.980 1.000 1.000 593 ACE2PATHWAY Angiotensin-converting enzyme 2 (ACE2) digests the blood-pressure regulator angiotensin II (AGT) ultimately to the vasodilator AGT1-7. ACE2, AGT, AGTR1, AGTR2, CMA1, COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6, REN 12 ACE2(1), AGT(1), AGTR1(1), CMA1(1), COL4A1(1), COL4A2(1), COL4A3(4), COL4A4(1), COL4A5(7), COL4A6(4), REN(1) 16040168 23 21 23 10 3 9 1 6 4 0 0.786 1.000 1.000 594 CELL2CELLPATHWAY Epithelial cell adhesion proteins such as cadherins transduce signals into the cell via catenins, which alter cell shape and motility. ACTN1, ACTN2, ACTN3, BCAR1, CSK, CTNNA1, CTNNA2, CTNNB1, PECAM1, PTK2, PXN, SRC, VCL 13 ACTN1(1), ACTN2(3), ACTN3(1), BCAR1(3), CSK(2), CTNNA1(2), CTNNA2(4), CTNNB1(1), PTK2(1), SRC(2), VCL(2) 11855282 22 21 22 12 4 4 1 10 3 0 0.966 1.000 1.000 595 SPPAPATHWAY Thrombin cleaves protease-activated receptors PAR1 and PAR4 to induce calcium influx and activate platelet aggregation, a process inhibited by aspirin. F2, F2R, F2RL3, GNAI1, GNB1, GNGT1, HRAS, ITGA1, ITGB1, MAP2K1, MAPK1, MAPK3, PLA2G4A, PLCB1, PRKCA, PRKCB1, PTGS1, PTK2, RAF1, SRC, SYK, TBXAS1 21 F2(3), GNAI1(1), GNB1(2), HRAS(1), ITGA1(3), ITGB1(3), MAPK3(1), PLA2G4A(1), PLCB1(1), PTGS1(1), PTK2(1), SRC(2), SYK(1), TBXAS1(1) 15086673 22 21 22 13 2 3 3 7 7 0 0.979 1.000 1.000 596 PROSTAGLANDIN_SYNTHESIS_REGULATION ANXA1, ANXA2, ANXA3, ANXA4, ANXA5, ANXA6, ANXA8, CYP11A1, EDN1, EDNRA, EDNRB, HPGD, HSD11B1, HSD11B2, PLA2G4A, PRL, PTGDR, PTGDS, PTGER1, PTGER2, PTGER4, PTGFR, PTGIR, PTGIS, PTGS1, PTGS2, S100A6, SCGB1A1, TBXAS1 27 ANXA3(1), ANXA4(1), ANXA6(1), CYP11A1(1), EDNRB(1), HPGD(1), PLA2G4A(1), PTGDR(1), PTGDS(1), PTGER2(1), PTGER4(1), PTGFR(2), PTGIR(1), PTGS1(1), PTGS2(4), TBXAS1(1) 12538726 20 20 20 12 1 3 3 8 5 0 0.971 1.000 1.000 597 ST_GRANULE_CELL_SURVIVAL_PATHWAY The survival and differentiation of granule cells in the brain is controlled by pro-growth PACAP and pro-apoptotic ceramides. ADPRT, APC, ASAH1, CAMP, CASP3, CERK, CREB1, CREB3, CREB5, CXCL2, DAG1, EPHB2, FOS, GNAQ, IL8RB, ITPKA, ITPKB, JUN, MAP2K4, MAP2K7, MAPK1, MAPK10, MAPK8, MAPK8IP1, MAPK8IP2, MAPK8IP3, MAPK9, PACAP 25 APC(6), ASAH1(1), EPHB2(1), ITPKA(1), ITPKB(1), JUN(2), MAP2K7(1), MAPK10(1), MAPK8IP1(2), MAPK8IP2(1), MAPK8IP3(1), MAPK9(2) 17169842 20 20 20 10 4 2 3 10 1 0 0.867 1.000 1.000 598 GLUTATHIONE_METABOLISM ANPEP, G6PD, GCLC, GCLM, GGT1, GPX1, GPX2, GPX3, GPX4, GPX5, GSS, GSTA1, GSTA2, GSTA3, GSTA4, GSTM1, GSTM2, GSTM3, GSTM4, GSTM5, GSTO2, GSTP1, GSTT1, GSTT2, GSTZ1, IDH1, IDH2, MGST1, MGST2, MGST3, PGD 31 ANPEP(6), G6PD(2), GGT1(2), GPX3(2), GPX4(1), GSS(1), GSTA3(1), GSTA4(1), GSTM1(1), IDH1(2) 11232717 19 18 19 10 1 0 5 10 3 0 0.978 1.000 1.000 599 CCR3PATHWAY CCR3 is a G-protein coupled receptor that recruits eosinophils to inflammation sites via chemokine ligands. ARHA, CCL11, CCR3, CFL1, GNAQ, GNAS, GNB1, GNGT1, HRAS, LIMK1, MAP2K1, MAPK1, MAPK3, MYL2, NOX1, PIK3C2G, PLCB1, PPP1R12B, PRKCA, PRKCB1, PTK2, RAF1, ROCK2 21 CFL1(1), GNAS(4), GNB1(2), HRAS(1), MAPK3(1), MYL2(1), NOX1(2), PIK3C2G(2), PLCB1(1), PTK2(1), ROCK2(3) 15794685 19 17 19 11 1 2 0 12 4 0 0.993 1.000 1.000 600 O_GLYCAN_BIOSYNTHESIS GALNT1, GALNT10, GALNT2, GALNT3, GALNT4, GALNT6, GALNT7, GALNT8, GALNT9, GCNT1, SIAT4A, SIAT4B, ST3GAL1, ST3GAL2, ST3GAL4, WBSCR17 14 GALNT1(1), GALNT10(1), GALNT2(1), GALNT6(1), GALNT7(5), GALNT9(1), GCNT1(2), ST3GAL1(1), WBSCR17(4) 9070518 17 17 17 11 0 1 6 6 4 0 0.993 1.000 1.000 601 HSA00565_ETHER_LIPID_METABOLISM Genes involved in ether lipid metabolism AGPAT1, AGPAT2, AGPAT3, AGPAT4, AGPAT6, AGPS, CHPT1, ENPP2, ENPP6, LYCAT, PAFAH1B1, PAFAH1B2, PAFAH1B3, PAFAH2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6, PLD1, PLD2, PPAP2A, PPAP2B, PPAP2C 30 AGPAT6(1), AGPS(1), CHPT1(1), ENPP2(1), PAFAH1B1(1), PAFAH2(1), PLA2G12A(1), PLA2G4A(1), PLA2G6(2), PLD1(2), PLD2(2), PPAP2B(1), PPAP2C(2) 14415375 17 16 17 9 1 2 4 10 0 0 0.912 1.000 1.000 602 CALCINEURINPATHWAY Increased intracellular calcium activates the phosphatase calcineurin in differentiating keratinocytes. CALM1, CALM2, CALM3, CDKN1A, GNAQ, MARCKS, NFATC1, NFATC2, NFATC3, NFATC4, PLCG1, PPP3CA, PPP3CB, PPP3CC, PRKCA, PRKCB1, SP1, SP3, SYT1 17 CALM2(1), CDKN1A(1), NFATC1(1), NFATC2(1), NFATC3(3), NFATC4(3), PPP3CA(1), PPP3CC(1), SP3(1), SYT1(1) 12257733 14 14 14 11 2 3 2 5 2 0 0.992 1.000 1.000 603 ERBB4PATHWAY ErbB4 (aka HER4) is a receptor tyrosine kinase that binds neuregulins as well as members of the EGF family, which also target EGF receptors. ADAM17, ERBB4, NRG2, NRG3, PRKCA, PRKCB1, PSEN1 6 ERBB4(6), NRG2(2), NRG3(2) 5666673 10 10 10 5 1 3 0 6 0 0 0.850 1.000 1.000 604 HSA00592_ALPHA_LINOLENIC_ACID_METABOLISM Genes involved in alpha-Linolenic acid metabolism ACOX1, ACOX3, FADS2, PLA2G10, PLA2G12A, PLA2G12B, PLA2G1B, PLA2G2A, PLA2G2D, PLA2G2E, PLA2G2F, PLA2G3, PLA2G4A, PLA2G5, PLA2G6 15 ACOX1(1), ACOX3(2), FADS2(2), PLA2G12A(1), PLA2G4A(1), PLA2G6(2) 6430723 9 9 9 5 2 1 2 4 0 0 0.805 1.000 1.000 605 CCR5PATHWAY CCR5 is a G-protein coupled receptor expressed in macrophages that recognizes chemokine ligands and is targeted by the HIV envelope protein GP120. CALM1, CALM2, CALM3, CCL2, CCL4, CCR5, CXCL12, CXCR4, FOS, GNAQ, JUN, MAPK14, MAPK8, PLCG1, PRKCA, PRKCB1, PTK2B, SYT1 17 CALM2(1), CCL2(1), CXCR4(1), JUN(2), MAPK14(1), PTK2B(2), SYT1(1) 8428473 9 8 9 7 1 3 1 4 0 0 0.965 1.000 1.000 606 MITOCHONDRIAPATHWAY Pro-apoptotic signaling induces mitochondria to release cytochrome c, which stimulates Apaf-1 to activate caspase 9. APAF1, BAK1, BAX, BCL2, BCL2L1, BID, BIK, BIRC2, BIRC3, BIRC4, CASP3, CASP6, CASP7, CASP8, CASP9, CYCS, DFFA, DFFB, DIABLO, ENDOG, PDCD8 19 BID(1), BIRC2(3), BIRC3(2), CASP7(1) 8384011 7 7 7 4 0 2 1 4 0 0 0.862 1.000 1.000 607 NOTCHPATHWAY Proteolysis and Signaling Pathway of Notch ADAM17, DLL1, FURIN, NOTCH1, PSEN1, RBPSUH 5 DLL1(1), NOTCH1(3) 5132206 4 4 4 3 0 1 0 3 0 0 0.946 1.000 1.000 608 FXRPATHWAY The nuclear receptor transcription factors FXR and LXR are activated by cholesterol metabolites and regulate cholesterol homeostasis. FABP6, LDLR, NR0B2, NR1H3, NR1H4, RXRA 6 LDLR(1), NR1H3(1), NR1H4(1) 3221997 3 3 3 3 0 1 0 2 0 0 0.974 1.000 1.000 609 IONPATHWAY Activated phospholipase C hydrolyzes the lipid PIP3 into second messengers DAG, which activates protein kinase C, and IP3, which induces calcium influx into the cytoplasm. P2RY2, PLCG1, PRKCA, PRKCB1, PTK2B 4 P2RY2(1), PTK2B(2) 4134066 3 3 3 6 0 2 0 1 0 0 0.997 1.000 1.000 610 PARKINPATHWAY In Parkinson's disease, dopaminergic neurons contain Lewy bodies consisting of alpha-synuclein and parkin, an E3 ubiquitin ligase that targets glycosylated alpha-synuclein. GPR37, PARK2, PNUTL1, SNCA, SNCAIP, UBE2E2, UBE2F, UBE2G1, UBE2G2, UBE2L3, UBE2L6, UBL1 10 GPR37(1), SNCAIP(1), UBE2E2(1) 3943564 3 3 3 3 0 2 1 0 0 0 0.906 1.000 1.000 611 TERCPATHWAY hTERC, the RNA subunit of telomerase, and hTERT, the catalytic protein subunit, are required for telomerase activity and are overexpressed in many cancers. NFYA, NFYB, NFYC, RB1, SP1, SP3 6 RB1(1), SP3(1) 4177849 2 2 2 2 0 2 0 0 0 0 0.962 1.000 1.000 612 VOBESITYPATHWAY The adipose tissue of obese individuals overexpresses a key glucocorticoid-metabolizing enzyme, activating inactive circulating corticosteroids and inducing insulin resistance. APM1, HSD11B1, LPL, NR3C1, PPARG, RETN, RXRA, TNF 7 LPL(1), PPARG(1) 3394881 2 2 2 2 1 1 0 0 0 0 0.902 1.000 1.000 613 HSA00031_INOSITOL_METABOLISM Genes involved in inositol metabolism ALDH6A1, TPI1 2 TPI1(1) 993669 1 1 1 2 0 0 1 0 0 0 0.982 1.000 1.000 614 HSA00660_C5_BRANCHED_DIBASIC_ACID_METABOLISM Genes involved in C5-branched dibasic acid metabolism ILVBL, SUCLA2 2 ILVBL(1) 1301999 1 1 1 2 0 0 0 1 0 0 0.989 1.000 1.000 615 HSA00627_1,4_DICHLOROBENZENE_DEGRADATION Genes involved in 1,4-dichlorobenzene degradation CMBL 1 316078 0 0 0 1 0 0 0 0 0 0 1.000 1.000 1.000 616 PLCDPATHWAY Phospholipase C (PLC-d1) hydrolyzes the membrane lipid PIP2 to DAG and IP3, which induce calcium influx and activates protein kinase C. ADRA1B, PLCD1, PRKCA, PRKCB1, TGM2 4 3004629 0 0 0 3 0 0 0 0 0 0 1.000 1.000 1.000